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Molecular
Weight
CD Antigen Other Names (kD) Cellular Expression Ligand/Receptor/Association Functions
CD1a R4, T6, HTA1 49 cortical thymocytes, Langerhans, DC assoc. w/ b2m non-peptide Ag presentation
CD1b R1, T6 45 cortical thymocytes, Langerhans, DC assoc. w/ b2m non-peptide Ag presentation
cortical thymocytes, Langerhans, DC,
CD1c R7, M241, T6 43 B subset assoc. w/ b2m non-peptide Ag presentation
CD1d R3 49 intestinal epith, B subset, DC assoc. w/ b2m non-peptide Ag presentation
CD1e R4 28 DC (intracellular) assoc. w/ b2m non-peptide Ag presentation
CD2 T11, LFA-2, SRBC-R 50 T, thymo, NK, B subset CD58, CD59 and CD15 adhesion, T activation
signaling T activation, regulates
CD3g T3 20-26 mature T, diff levels on thymocytes assoc. w/ CD3/TCR complex TCR expression
signaling T activation, regulates
CD3d T3 21 mature T, diff levels on thymocytes assoc. w/ CD3/TCR complex TCR expression
signaling T activation, regulates
CD3e T3 20 mature T, diff levels on thymocytes assoc. w/ CD3/TCR complex TCR expression
thymo subset, T helper/inducer, T T activation, thymic
CD4 T4, L3T4, W3/25 55 regulatory, mono/mac MHC class II, HIV gp120, IL-16 differentiation, HIV receptor
regulates T-B lymphocyte
CD5 T1, Tp67, Leu-1, Ly-1 67 thymo, T, B subset, B-CLL CD72, assoc. w/ TCR or BCR interaction
thymo development, T cell
CD6 T12 105-130 thymo, T, B subset, neuron subset CD166, 3A11 activation
CD7 gp40 40 thymo, T, NK, stem cells CD7 ligand (K-12) T costimulation
thymo subset, cytotoxic T, NK, DC coreceptor for MHC class I
CD8a T8, Leu-2, Ly-2 32-34 subset MHC class I molecules
coreceptor for MHC class I
CD8b CD8, Lyt3 30-32 thymo subset, cytotoxic T MHC class I molecules
platelets, pre-B, eosino, baso, act T, IL-16, assoc. w/ CD63, CD81, cell adhesion and migration,
CD9 p24, MRP-1, DRAP-27 22-27 endoth, epith, stem cells CD82, CD315, and CD316 platelet activation
peptidase, regulates B cell
CD10 CALLA, NEP, gp100 100 B and T precursors, fibro, neutro growth
CD11a/CD18 binds to CD54, intercellular adhesion and
CD11a LFA-1, integrin aL 180 all leukocytes CD102, CD50, CD242 costimulation
CD11b/CD18 binds to CD54, iC3b cell adhesion, chemotaxis,
CD11b Mac-1, integrin aM 170 gran, mono, NK, T sub, B sub, DC and ECM , CD242 apoptosis
p150, 95, CR4, integrin mono/mac, NK, gran, T and B CD11c/CD18 binds to iC3b and
CD11c aX 150 subset, DC ECM cell adhesion
CDw12 90-120 mono, gran, platelets, NK unknown
gran, mono and their precursors, coronavirus, CMV, L-leucyl-b-
CD13 APN, gp150 150-170 endoth, epith, DC napthylamine zinc-binding metalloproteinase
receptor for complex of LPS and
CD14 LPS receptor 53-55 mono, mac, Langerhans, gran (low) LPS LBP
Lewis X (Lex), SSEA-1,
CD15 3-FAL gran, transient in brain CD62 cell adhesion
gran, mono, endoth, memory helper
CD15s Sialyl Lewis X T, act T and B, NK, HEV, endoth CD62E cell adhesion
gran, mono, T subset, B subset, NK,
CD15u 3' sulfated Lewis X endoth CD62P cell adhesion
gran, mono, T subset, B subset, NK,
CD15su 6' sulfated Lewis X endoth CD62L cell adhesion
low affinity Fcg receptor,
mediates phagocytosis and
CD16 FcgRIIIA, CD16a 50-65 neutro, NK, mac aggregated IgG, IgG-Ag complex ADCC
CD16b FcgRIIIB 48 neutrophils IgG
mono, platelets, B subset, gran, DC, lactosyl ceramide, a cell surface
CD17 CDw17 T glycosphingolipid
CD18 b2 integrin 95 leukocytes assoc. w/ CD11a,b and c cell adhesion
BCR coreceptor, signal
CD19 B4 95 B (not on plasma cells), FDC assoc. w/ CD21, CD81, BCR transduction
CD20 B1, Bp35, Ly-44 33-37 B, T subset B cell activation and proliferation
C3d, EBV, assoc w/ CD23, CD19,
CD21 CR2, EBV-R, C3dR 145, 110 mature B, FDC, T subset CD81, BCR signal transduction
CD22, IgM, CD45RO, sialoglyco-
conjugate NeuGca2-6Galb1- B cell adhesion, signal
CD22 BL-CAM, Siglec-2 130 B 4GlcNAc transduction
low affinity receptor for IgE,
CD23 FceRII, BLAST-2, Ly-42 45 B, act mac, eosino, FDC, platelets IgE, CD21, CD11b, CD11c ligand for CD19/CD21/CD81
B cell proliferation and
CD24 BA-1, HSA, Ly-52 35-45 B, gran, epith, mono P-selectin, CD24 differentiation
IL-2R a chain, assoc. w/ b and g
CD25 Tac, p55, IL-2Ra, Ly-43 55 act T, B, and mono; DC subset, T reg IL-2 chains to form high affinity IL-2R
Dipeptidyl peptidase IV mature thymo, T (upreg upon exoprotease, HIV pathogenesis,
CD26 (DPP IV) 110 activation), B, NK, mac, epith adenosine deaminase, collagen costim of T cell activation
T, medullary thymocytes, B subset,
CD27 T14, S152 50-55 NK CD70, TRAF2, TRAF5 costim of T and B cell activation
CD28 Tp44, T44 44 most T, thymo, plasma, NK CD80 (B7-1), CD86 (B7-2) costimulation
assoc. w/ integrin a subunits,
cell adhesion and activation,
T, B, mono, gran (low), platelets, embryogenesis and
CD29 integrin b1, gpIIa 130 mast, fibro, endoth, NK VCAM-1, MAdCAM-1, ECM development
act T, act B, mono, act NK, Reed- regulates lymphocyte
CD30 Ki-1, Ber-H2 105 Sternberg cells CD153 proliferation and cell death
mono, platelets, gran, endoth,
CD31 PECAM-1, endocam 130-140 lympho subset CD31, CD38 cell adhesion
regulation of B cell function,
induces phagocytosis and
CD32 FcgRII, Ly-17 40 B, mono, gran, platelets, endoth aggregated IgG, phosphatases mediators release
mono, gran, mast, myeloid certain sialic acids-linked lectin activity for sugar chains
CD33 p67, Siglec-3 67 progenitors carbohydrates containing sialic acid, adhesion
hemato stem cells and progenitors,
CD34 gp105-120, Mucosialin 105-120 endoth L-selectin cell adhesion
eryth, B, mono, neutro, eosino, FDC,
CD35 CR1, C3b/C4b-R 190-280 T subset C3b, C4b, iC3, iC4 adhesion and phagocytosis
platelets, mono/mac, endoth and oxidized LDL, thrombospondin, scavenger receptor, mediates
CD36 GPIV, gpIIIb 85 erythroid precursors collagen adhesion and phagocytosis
CD37 gp 52-40 40-52 mature B, low on T, gran, mono, DC CD53, CD81, CD82, MHC class II ahesion, signal transduction
variable levels on majority of hemato
T10, ADP-ribosyl and some non-hemato cells, high on regulates cell activation,
CD38 cyclase 42 plasma cells CD31 proliferation and adhesion
mac, Langerhans, DC, act B, NK, B cell adhesion, protects act
CD39 Entpd1, NTPDase-1 78 microglia ADP/ATP cells from lysis
costim of B cell growth,
B, mono/mac, FDC, endoth, fibro, differentiation and isotype-
CD40 Bp50 48 keratinocytes CD154 switching
assoc. w/ CD61 to form GPIIb-IIIa
complex, binds to fibrinogen,
120/23 fibronectin, vWF and platelet activation and
CD41 gpIIb, aIIb integrin dimer platelets, megakaryocytes thrombospondin aggregation
complexed with each other as
CD42a gpIX 17-22 platelets, megakaryocytes receptor for vWF and thrombin platelet adhesion and activation
CD42b gpIba 145 platelets, megakaryocytes
CD42c gpIbb 24 platelets, megakaryocytes
CD42d gpV 82 platelets, megakaryocytes
sialophorin, leukosialin, leuko, except resting B, platelets anti-adhesion, also binds to
CD43 gpL115 115-135 (low) CD54, CD62E CD54 to mediate adhesion
H-CAM, Pgp-1, EMCR hemato and non-hemato cells, except leukocyte rolling, homing, and
CD44 III, CD44s, Ly-24 85 platelets hyaluronan aggregation
heterogeneous for diff isoforms,
constitutively expressed on epith, leukocyte rolling, homing, and
CD44R CD44v 85-250 mono, upreg on act leuko hyaluronan aggregation
hemato cells, except eryth and galectin-1, assoc. w/ CD2, CD3, critical for T- and B-cell receptor
CD45 LCA, T200, B220, Ly-5 180-240 platelets CD4 and CD45AP mediated activation
B, T subset (naive T), mono, isoform of CD45 containing the A critical for T- and B-cell receptor
CD45RA 205-220 medullary thymo exon mediated activation
T subset, B, mono, mac, gran, DC, isoform of CD45 containing the B critical for T- and B-cell receptor
CD45RB 190-220 NK exon mediated activation
B, NK, CD8+ T, subset of CD4+ T, isoform of CD45 containing the C critical for T- and B-cell receptor
CD45RC 220 medullary thymo, mono, DC exon mediated activation
act T and memory T, B subset, act
mono, mac, gran, cortical thymo, DC CD22, isoform of CD45 containing critical for T- and B-cell receptor
CD45RO UCHL-1 180 subset none of the A, B and C exons mediated activation
co-factor for factor I proteolytic
cleavage of C3b and C4b, sets
leuko, platelets, endoth, epith, a protective barrier threshold
placental trophoblasts, sperm and against inappropriate
CD46 MCP 64-68 variety of tumor cells C3b, C4b, measles virus complement activation
hemato cells, epith, endoth, fibro,
CD47 IAP 50-55 brain, mesenchymal cells CD172a, CD172g adhesion
CD47R
CD48 Blast-1, BCM1, Sgp-60 45 leukocytes CD242, Ly9 cell adhesion, T costim
assoc. w/ CD29, binds to
CD49a VLA-1a, a1 integrin 200 act T, mono, melanoma cells, endoth collagen, laminin-1 adhesion, embryo development
VLA-2a, gpIa, a2 platelets, B, mono, act T, epith, assoc. w/ CD29, binds to adhesion, platelet aggregation,
CD49b integrin 160 endoth, NK subset, megakar collagen, echovirus 1 receptor for echovirus 1
most adhesion cell lines, low on B assoc. w/ CD29, binds to
CD49c VLA-3a, a3 integrin 125 and T collagen, laminin-5, fibronectin adhesion, signal transduction
T, B, thymo, mono, eosino, baso, assoc. w/ CD29 or b7 integrin,
NK, mast, DC, erythroblastic binds to VCAM-1, MAdCAM-1, adhesion, cell migration, homing
CD49d VLA-4a, a4 integrin 150 precursors fibronectin, CD242 and activation
thymo, T, mono, platelets, early and assoc. w/ CD29, binds to adhesion, regulation of cell
CD49e VLA-5a, a5 integrin 135, 25 act B, endoth, epith fibronectin, invasin survival and apoptosis
memory T, thymo, mono, platelets,
megakar, epith, epith, endoth, assoc. w/ CD29 or b4 (CD104), adhesion, cell migration,
CD49f VLA-6a, a6 integrin 125 cytotrophoblasts binds to laminins, invasin embryogenesis
CD50 ICAM-3 120-140 leuko, thymo, Langerhans, endoth CD11a/CD18 adhesion and costimulation
assoc. w/ integrin b1, b3, b5, b6 or
vitronectin receptor, 125, 24 platelets, act T, endoth, osteoblasts, b8, binds to fibrinogen,
CD51 integrin aV dimer melanoma cells, megakar thrombospondin, vWF, CD242 adhesion, signal transduction
thymo, lympho, mono/mac, epith, costimulation, antibodies are
CD52 CAMPATH-1, HE5 25-29 spermatozoa useful for lysis of target cells
CD53 OX-44 32-42 leuko, DC, osteoblasts, osteoclasts VLA-4, MHC class II molecules signal transduction
extravasation of leukocytes from
endoth, epith, mono, low on resting CD11a/CD18, CD11b/CD18, blood vessels, regulates T cell
CD54 ICAM-1 90/95 lympho, upreg upon activation Rhinovirus, CD43 activation
regulates complement
activation, ligand or protective
C3b, C4b, CD97, Coxsackie virus, molecule in fertilization, signal
CD55 DAF 60-70 hemato and non-hemato cells Echovirus transduction
neural tissue, NK, T subset, small-cell homophilic and heterophilic
CD56 NCAM, Leu-19, NKH-1 175-220 lung carcinomas NCAM, heparin sulfate adhesion
NK subset, T subset, some B cell
CD57 HNK-1, Leu-7 110 lines CD62L, CD62P adhesion
APC-T, killer-target cell
CD58 LFA-3 55-70 leuko, eryth, epith, endoth, fibro CD2 interaction, costimulation
prevents complement
polymerization, protects cells
CD59 Protectin, H19, 1F-5Ag 19-25 hemato and non-hemato cells C8a, C9, lck, fyn from complement-mediated lysis
T subset, thymo, melanocytes, glial regulation of apoptosis,
CD60a GD3 cells, platelets, gran costimulation
CD60b 9-O-sialyl GD3 T subset, act B, melanomas costimulation
CD60c 7-O-sialyl GD3 T subset T cell activation
with CD41 on platelets, with CD51 on assoc. w/ CD41 or CD51, binds
mac, endoth, platelets, fibro, fibrinogen, vitronectin, fibronectin, mediates cell adhesion to
CD61 gpIIIa, b3 integrin 110 osteoclasts, mast vWF diverse matrix proteins
E-selectin, ELAM-1, leukocyte rolling, tumor cell
CD62E LECAM-2 97-115 act endothelial cells CD15s, ESL-1, CD162, CD43 adhesion, angiogenesis
L-selectin, LECAM-1,
CD62L LAM-1 74, 95 B, T subset, mono, gran, NK, thymo CD34, MAdCAM-1, GlyCAM-1 leukocyte rolling and homing
P-selectin, GMP-140,
CD62P PADGEM 140 act platelets, endoth CD162, CD24 leukocyte tethering and rolling
act platelets, mono, mac,
degranulated neutro, fibro,
CD63 LIMP, MLA1, LAMP-3 40-60 osteoclasts VLA-3, VLA-4, CD9, CD81 regulates cell motility
high affinity receptor for IgG,
mono, mac, DC, IFN-g or G-CSF act mediates phagocytosis, Ag
CD64 FcgRI, FcR I 72 gran IgG capture, and ADCC
gran and some mono, myeloid
CD65 Ceramide, VIM-2 leukemia cells E-selectin unknown
CD65s VIM2 gran, mono, myeloid leukemia cells phagocytosis
gran, epith, colon, liver, hemato homophilic and heterophilic
CD66a BGP, NCA-160 140-180 tissues CD66a, c, e adhesion, neutrophil activation
cell adhesion, neutrophil
CD66b CD67, CGM6, NCA-95 95-100 granulocytes CD66c activation
cell adhesion, neutrophil
CD66c NCA 90 neutro, epith, colon carcinoma CD66a, b, c, e activation
CD66d CGM1 35 neutrophils neutrophil activation
homophilic and heterophilic
CD66e CEA 180-200 adult colon epith, colon cancer CD66a, c, e adhesion
immune regulation and
epith, placental syncytiotrophoblasts, protection of fetus from maternal
CD66f PSG, Sp-1 54-72 fetal liver immune system
mac, neutro, baso, DC, myeloid
CD68 macrosialin, gp110 94-110 progenitors, act mono oxidized LDL phagocytosis
act leuko, NK, thymo subset,
CD69 AIM, VEA 28, 32 platelets, Langerhans signal-transmitting receptor
CD70 Ki-24, CD27L act B, act T CD27 costimulation
transferrin receptor, controls
proliferating cells, reticulocytes, iron uptake during cell
CD71 T9 95 erythroid precursors transferrin proliferation
B (except plasma cells), mac, FDC, T
CD72 Lyb-2 39 subset CD5, CD100 B cell activation and proliferation
catalyzes dephosphorylation,
T subset, B subset, FDC, epith, costim of T cell activation,
CD73 Ecto-5'-nucleotidase 70 endoth AMP lymphocyte-endoth adhesion
intracellular sorting of MHC
B, act T, mac, Langerhans, DC, act class II molecules, B cell
CD74 Ii, invariant chain 33,35,41 endoth and epith CD44, MHC class II, MIF activation
CD75 lactosamines B sub, T sub, eryth CD22 cell adhesion
CDw75, CDw76, a2,6-
sialylated 34, 37,
CD75s lactosamines 43, 200 majority B, T sub, endo, epi sub CD22 cell adhesion
B subset, T subset, endoth, epith
CDw76 subset
germinal center B, high expression
CD77 Pk Ag, BLA, CTH, Gb3 on Burkitt's lymphomas Shiga Toxin, VT1 induces apoptosis
subunit of BCR complex, signal
CD79a Iga, MB1, Ly-54 33, 45 B Ig/CD5/CD19/CD22/CD79b transduction
subunit of BCR; signal
CD79b Igb, B29 37 B Ig/CD5/CD19/CD22/CD79a transduction
costim of T cell activation and
CD80 B7, B7-1, BB1, Ly-53 60 act B, act T, mac, DC CD28, CD152 proliferation
T, B, NK, mono, thymo, DC, endoth, assoc. w/ CD19, CD21, CD225, activation costimulation,
CD81 TAPA-1 26 fibro CD315 and CD316 proliferation, differentiation
assoc. w/ MHC molecules, CD4,
leuko, upreg upon activation, CD8, CD20, CD37, CD81, costimulation, signal
CD82 R2, 4F9, C33 45-90 platelets integrins transduction
CD83 HB15 43 mature DC, act T, act B, Langerhans CD83L costimulation
mature B, T subset, mono/mac,
CD84 GR6 72-86 platelets, thymo CD84 adhesion, T cell activation
CD85a LIR-3, ILT5, LILRB3 mono/mac, gran, DC, T subset MHC class I molecules inhibition of NK cell cytotoxicity
CD85b ILT8 mono, DC, B, NK, T subset FcRg activation of NK cell cytotoxicity
CD85c LIR-8, LILRB5 mono, DC, B, NK, T subset FcRg activation of NK cell cytotoxicity
CD85d LIR-2, ILT4, LILRB2 mono, DC, B, NK, T subset MHC class I molecules inhibition of NK cell cytotoxicity
CD85e LIR-4, ILT6, LILRA3 mono, DC, B, NK, T subset FcRg activation of NK cell cytotoxicity
CD85f LIT11 mono, DC, B, NK, T subset FcRg activation of NK cell cytotoxicity
CD85g ILT7 mono, DC, B, NK, T subset FcRg activation of NK cell cytotoxicity
CD85h LIR-7, ILT1, LILRA2 mono, DC, B, NK, T subset, gran FcRg activation of NK cell cytotoxicity
CD85i LIR-6, LILRA1 mono, DC, T subset FcRg activation of NK cell cytotoxicity
CD85j LIR-1, ILT2, LILRB1 110 lympho, mono/mac, DC MHC class I molecules, UL18 inhibition of NK cell cytotoxicity
CD85k LIR-5, ILT3, LILRB4 gran, mono/mac, DC MHC class I molecules inhibition of NK cell cytotoxicity
CD85l ILT9 NK, T subset, mono/mac, DC, B FcRg
CD85m ILT10 T subset, mono/mac, DC, B FcRg
costim of T cell activation and
CD86 B70, B7-2 80 mono, act B, act T, DC, endoth CD28, CD152 proliferation
gran, mono, NK, T, endoth, fibro,
CD87 uPAR 32-66 hepato uPA, vitronectin cell chemotaxis, adhesion
CD88 C5aR 43 gran, mono, DC, astrocytes C5a granulocyte activation
induces phagocytosis,
CD89 FcaR, IgA receptor 45-100 mono/mac, gran IgA1, IgA2 degranulation, respiratory burst
may inhibit hemato stem cell
HSC, neurons, fibro, stromal cells, and neuron differentiation,
CD90 Thy-1 25-35 HEV endoth CD51/CD61, Mac-1 costim of lymphocytes
metabolism, phagocytosis,
CD91 a2M-R, LRP 600 mono, mac, neurons, fibro a2M, LDLs, HSP96, lipoprotein antigen presentation
CD92 CDw92 70 gran, mono, endoth, epith, fibro
CD93 CDw93 120 mono, gran, endoth C1q phagocytosis, adhesion
CD94/NKG2A inhibits NK cell
function, triggers cytolytic
CD94 Kp43 43, 39 NK, T subset HLA-E, assoc. w/ NKG2 activity and cytokine production
mono, neutro, lympho (upreg upon
CD95 Fas, APO-1 45 activation), fibro Fas ligand (CD95L, CD178) induces apoptosis
adhesion of act T and act NK
CD96 TACTILE 160 NK and T (upreg upon activation) CD155 cells
gran, mono, low on lympho (upreg
CD97 EMR1 28, 74-85 upon activation), mac, DC CD55, chondroitin sulfates neutrophil migration, adhesion
mono, lympho and NK (upreg upon
CD98 4F2, FRP-1, RL-388 80, 45 activation), gran CD29, CD147, tropomyosin, actin cell activation, cell aggregation
lympho, NK, mono, gran, endoth, leukocyte migration, T cell
CD99 MIC2, E2 32 epith, some tumor cells cyclophilin A activation, cell adhesion
CD99R E2 32 T, NK, myeloid cells isoform of CD99
monocyte migration; T, B
activation; T/B and T/DC
CD100 SEMA4D 150 leuko, oligodendrocytes CD45, CD72, plexin B interaction
CD101 V7, p126 120 mono, gran, DC, act T, Langerhans T cell activation and proliferation
adhesion, costim, lymphocyte
CD102 ICAM-2 55-65 lympho, mono, platelets, endoth LFA-1, Mac-1 recirculation
HML-1, aE integrin, intraepithelial lympho, some complexed with b7 integrin, binds
CD103 aIEL 150,25 peripheral blood lympho, act lympho E-cadherin lymphocyte retention, activation
epith, endoth, Schwann cells, complexed with CD49f, binds cell adhesion, migration, tumor
CD104 b4 integrin, TSP-180 220 keratinocytes laminins, plectin metastasis
endoth, mesenchymal stem cells, angiogenesis, modulates cellular
CD105 Endoglin 90 erythroid precursors, act mono, mac TGF-b1, TGF-b3 response to TGFb1
leukocyte adhesion,
transmigration and costim of T
CD106 VCAM-1, INCAM-110 110 act endoth, FDC CD49d/CD29, a9/b1 integrin cells
act platelets, act T, act endoth, act
CD107a LAMP-1 100-120 gran possible role in cell adhesion
CD107b LAMP-2 100-120 act platelets, act T, act endoth possible role in cell adhesion
negative regulation T cell
CDw108 SEMA7A, JMH 80 act T, erythrocytes CD232 function, Axon growth
act T, act platelets, subset of CD34+
CD109 8A3, 7D1, E123 175 cells, endoth TGF-b
HSC and progenitors, megakar, TPO receptor, megakaryocyte
CD110 MPL, TPO-R 85-92 platelets thrombopoietin, JAK2 differentiation
stem cell subset, neuronal cells, homophilic and intercellular
CD111 PRR1, Nectin-1, PVRL1 75 endoth, epith, fibro nectin-3, Afadin, HSVgD adhesion, HSV receptor
mono, neutro, subset of CD34+ cells,
CD112 PRR2, Nectin-2, HveB 72, 64 endoth, epith CD226, PRR3, Afadin adhesion
PVRL3, Nectin-3, PRR3,
CD113 CDw113 83 epith, testis, placenta, liver nectin-1, nectin-2, PVR cell adhesion
myeloid progenitor cells, endoth,
CD114 G-CSFR, CSF-3R 130 trophoblastic cells G-CSF, JAK1, JAK2 myeloid cell differentiation
M-CSFR, c-fms, CSF- mono, mac, monocytic progenitors,
CD115 1R 150 neuronal cells, osteoclasts M-CSF monocytic cell differentiation
assoc. w/ CDw131, binds GM-
CD116 GM-CSFRa 80 mono/mac, gran, DC, endoth CSF myeloid cell differentiation
crucial for the development of
hemato stem cells and progenitors, hemato, gonadal and pigment
CD117 c-kit, SCFR 145 mast cells SCF (c-kit ligand) stem cells
mono, fibro, embryonic stem cells, assoc. w/ CD130, binds LIF, LIF receptor, cell differentiation,
CD118 LIFR, gp190 190 liver, placenta OSM, CNTF, CT1 proliferation
assoc. w/ IFNgAF-1, involved in
lympho, NK, mono/mac, gran, host defense and
CD119 IFNgR, IFNgRa, CDw119 90-100 endoth, epith IFN-g immunopathological process
cell differentiation, apoptosis,
low level on leukocytes and most non- necrosis; anti-bacterial, viral and
CD120a TNFR-I, p55 50-60 hemato cells TNF-a and TNF-b parasitic infection
cell differentiation, apoptosis,
necrosis; anti-bacterial, viral and
CD120b TNFR-II, p80 75-85 leukocytes and non-hemato cells TNF-a and TNF-b parasitic infection
low level on fibro, lympho, mono/mac, assoc. w/ IL-1R AcP, mediates
CD121a IL-1R type I 80 gran, DC, epith, neural cells IL-1a, IL-1b, IL-1RA IL-1 signaling
CD121b IL-1R type II, CDw121b 60-70 B, mono/mac, some T, keratinocytes IL-1a, IL-1b, IL-1RA mediates negative signaling
IL-2, IL-15, assoc. w/ CD25, IL-2 and IL-15 receptor b chain,
CD122 IL-2Rb 75 NK, T, B, mono CD132 signaling
baso, eosino, hemato progenitors,
mac, DC, endoth, small subset of IL-3 receptor a chain, assoc. w/
CD123 IL-3Ra 70 lympho IL-3 CD131
low level on lymphocytes and their assoc. w/ CD132 or IL-13Ra
progenitors, mono, endoth, epith, chain, receptor for IL-4 and IL-
CD124 IL-4Ra 140 fibro IL-4, IL-13 13
assoc. w/ CD131, receptor for IL-
CD125 IL-5Ra, CDw125 60 eosino, baso, act B, mast IL-5 5
act B and plasma cells, T, mono, binds IL-6, then assoc. w/
CD126 IL-6Ra 80 gran, epith, fibro IL-6 signaling subunit CD130
IL-7 receptor a chain, assoc. w/
CD127 IL-7R, IL-7Ra 65-90 B precursors, majority of T, thymo IL-7 CD132
CDw129
transducing biological activities
assoc. w/ CD126, IL-11R or LIF- of IL-6, IL-11, LIF, CNF and
CD130 gp130 130-140 T, act B, plasma cells, mono, endoth R, OSMRb Oncostatin M
IL-3Rb, common b transducing signals of IL-3R, IL-
CD131 chain, CDw131 120-140 mono, gran, early B, HSC assoc. w/ CD123, CD125, CD116 5R and GM-CSFR
subunits of IL-2, IL-4, IL-7, IL-9,
CD132 common g chain, IL-2Rg 64 T, B, NK, mono/mac, gran, DC and IL-15 receptors signal transduction
HSC subset, epith and endoth
CD133 AC133, Prominin-1 120 precursors, neural precursors
T cell activation, proliferation,
differentiation, and apoptosis;
CD134 OX-40 48-50 act T, T regulatory CD134 ligand cell adhesion
multipotential, myelomonocytic, and receptor tyrosine kinase,
CD135 Flt3/Flk2, STK-1 155, 160 primitive B progenitors flt3 ligand hemato progenitors growth
induction of migration,
mac, epith, some hemato and morphological change and
CD136 MSP-R, RON, CDw136 150, 40 carcinoma cell lines MSP, HGFI proliferation, anti-apoptosis
CD137 4-1BB, CDw137 39 act T, FDC, mono, act B, epith 4-1BB ligand costim of T cell activation
plasma cells, pre-B, epith, neural
CD138 syndecan-1 85-92 cells, breast cancer cells ECM receptor, adhesion
CD139 209, 228 B, mono, gran, DC, eryth
fibro, mesenchymal cells, platelets, cell proliferation, differentiation,
CD140a PDGF-Ra 180 glial cells and chondrocytes PDGF-A, PDGF-B, PDGF-C and survival
fibro, mesenchymal cells, platelets, cell proliferation, differentiation,
CD140b PDGF-Rb 180 glial cells and chondrocytes PDGF-B, PDGF-D and survival
initiation of protein C anti-
CD141 Thrombomodulin 105 mono, neutro, platelets, endoth thrombin coagulant pathway
mono, epith, astrocytes, Schwann
CD142 Tissue Factor, Factor III 45-47 cells, endoth,smooth muscle complexed with factor VIIa initiates blood clotting
endoth, epith, DC, neuronal cells,
CD143 ACE 90, 170 fibro, act mac angiotensin I, bradykinin angiotensin converting enzyme
VE-Cadherin, Cadherin-
CD144 5 130 endoth, stem cell subset CD144, b catenin cell adhesion
CDw145 90, 110 endoth, some stromal cells
CD146 MUC18, S-endo 130 endoth, melanoma cells, FDC, act T cell adhesion
Neurothelin, basigin,
CD147 EMMPRIN 55-65 leuko, eryth, platelets, endoth cell adhesion, T cell activation
gran, mono, DC, platelets, B, act T, tyrosine phosphatase, adhesion,
CD148 HPTP-eta, p260, DEP-1 200-260 endoth, epith p120(ctn) angiogensis
T (upreg upon activation), T CD150, measles virus, tyrosine adhesion, costim, signaling,
CD150 SLAM, IPO-3 75-95 regulatory, B, DC, endoth, HSC phosphatase CD45 measles virus infection
CD151 PETA-3 32 endoth, megakar, platelets, epith b1 integrins, CD151 adhesion, signal transduction
negative regulation of T cell
CD152 CTLA-4, Ly-56 33 act T, act B CD86, CD80 activation
CD153 CD30L 40 act T, act mac, act neutro, act B CD30 costimulation of T cell activation
CD40L, T-BAM, gp39,
CD154 TRAP, Ly-62 32-39 act T, act platelets, act mono CD40 costimulation
cell migration and adhesion,
CD155 PVR 60-90 mono, mac, some tumor cells polio virus, vitronectin, CD226 polio virus infection
CD156a ADAM8, MS2, CD156 69 mono, gran cell adhesion
cleaves transmembrane forms
lympho, mono, gran, DC, endoth, of TNF-a and TGF-a to
CD156b TACE, ADAM 17 100-120 epith TNF-a, TGF-a generate soluble forms
98, 85, 58, articular chondrocytes, leuko, brain, metalloprotease activity; cell-
CD156c ADAM10, CDw156c 56 tumor cells pro-TNF-a, APP, Notch cell, cell-matrix interaction
gran, mono, B cell progenitors, ADP-ribosyl-cyclic ADP-ribose
CD157 BST-1, Ly-65, Bp3 42-45 endoth, T subset hydrolase, adhesion
CD158a KIR2DL1, p58.1 58/50 most NK, T subset HLA-Cw2, Cw4, Cw5, Cw6 inhibits NK cell cytotoxicity
CD158b1 KIR2DL2, p58.2 58/50 most NK, T subset HLA-Cw1, Cw3, Cw7, Cw8 inhibits NK cell cytotoxicity
CD158b2 KIR2DL3, p58 58/50 most NK, T subset HLA-Cw1, Cw3, Cw7, Cw8 inhibits NK cell cytotoxicity
KIR3DP1, KIR2DS6,
CD158c KIRX most NK, T subset inhibits NK cell cytotoxicity
CD158d KIR2DL4, KIR103AS 41 NK, some T HLA-G activates NK cell cytotoxicity
KIR3DL1, NKB1,
CD158e1 NKB1B, p70 70 NK, some T HLA-Bw4 inhibits NK cell cytotoxicity
CD158e2 KIR3DS1, NKAT10 70 NK, some T HLA-Bw4 activates NK cell cytotoxicity
CD158f KIR2DL5A NK, some T HLA-B inhibits NK cell cytotoxicity
CD158g KIR2DS5 NK, some T activates NK cell cytotoxicity
CD158h KIR2DS1 NK, some T HLA-C activates NK cell cytotoxicity
CD158i KIR2DS4 50 NK, some T HLA-C activates NK cell cytotoxicity
CD158j KIR2DS2 NK, some T HLA-C activates NK cell cytotoxicity
CD158k KIR3DL2 70 NK, some T HLA-A inhibits NK cell cytotoxicity
CD158z KIR3DL3, KIRC1 NK, some T inhibits NK cell cytotoxicity
negative regulation of NK cell
CD159a NKG2A 43 NK, some T HLA-E, assoc. w/ CD94 activation
CD159c NKG2C, KLRC2 40 NK, CD8+ T subset assoc. w/ CD94, binds HLA-E activates NK cell cytotoxicity
CD160 BY55 27 NK subset, CTL, IEL HLA-C costimulation
NK cell-mediated cytotoxicity,
induces immature thymo
CD161 NKR-P1A 40 most NK, NK-T, memory T, thymo LLT1 proliferation
CD162 PSGL-1 110-120 mono, gran, most T, stem cells CD62P, CD62L adhesion, leukocyte rolling
CD162R PEN-5 140 NK CD62L
CD163 M130, GHI/61 100 mono, mac hemoglobin/hepatoglobin complex endocytosis
epith, mono, lympho, stromal cells,
CD164 MGC-24, MUC-24 80 hemato progenitors adhesion
lympho subset, mono, immature
CD165 AD2, gp37 42 thymo, platelets, epith adhesion
act T, mono, epith, fibro, neurons,
CD166 ALCAM 100-105 mesenchymal stem/progenitor cells CD6, CD166 adhesion, T cell activation
CD167a DDR1 52-62 epith, DC, inducible in leuko collagen collagen receptor
mono, T subset, thymo subset, act hyaluronic acid receptor, cell
CD168 RHAMM 80, 84, 88 lympho CD44 adhesion
CD169 sialoadhesin, Siglec-1 200 tissue macrophages CD227, CD206, CD43 adhesion
CD170 Siglec-5 140 mac, neutro, DC ganglioside adhesion
T subset, B subset, DC, mono,
CD171 L1CAM, N-CAM L1, L1 190-220 neurons L1, CD56, CD24, CD9, CD166 cell adhesion
CD172a SIRPa 110 mono, DC, gran, stem cells CD47 adhesion
CD172b SIRPb, SIRPb1 90, 60 mono, gran, DC, brain, kidney, testis assoc. w/ DAP12 phagocytosis, cell activation
CD172g SIRPg, SIRPb2 45-55 majority of T, act NK, B subset CD47 cell adhesion, costimulation
Blood group H 2, blood
CD173 group O eryth, stem cell subset, platelets
CD174 Lewis Y stem cell subset, epith
CD175 Tn stem cell subset, epith TFRA
CD175s Sialyl-TN erythroblasts, endoth, epith TFRA
CD176 T-F Ag stem cell subset, eryth, endoth TFRA
neutro, baso, NK cells, T subset,
CD177 NB1, HNA-2a 56-64 mono, endoth
CD178 FasL, CD95L, TNFSF6 27-40 act T, testis, DC, tumor cells CD95 induces apoptosis
CD179a V pre B 16-18 pro- and early pre-B CD179b, Igm chain early B cell differentiation
CD179b l5 22 pro- and early pre-B CD179a, Igm chain early B cell differentiation
LPS recognition and signaling, B
CD180 RP105 95-105 B subset, mono, DC LPS, assoc. w/ MD-1 cell activation
CXCR1, CDw128A, IL- neutro, baso, NK, T subset, mono, neutro chemotaxis and
CD181 8RA 67-70 endoth IL-8 activation, neoangiogenesis
neutro chemotaxis and
CXCR2, CDw128B, IL- neutro, baso, NK, T subset, mono, IL-8, GRO, GCP-2, NAP-2, ENA- activation, neoangiogenesis,
CD182 8RB 67-70 endoth 78 hematopoiesis
T subset, B, NK, mono/mac,
CD183 CXCR3 40 proliferating endoth CXCL9, CXCL10, CXCL11 T cell chemotaxis
cell migration, hemato
T sub, B sub, DC, mono, endoth, progenitor cell homing, HIV-1
CD184 CXCR4 45 HSC HIV-1, SDF-1(CXCL12) entry
CD185 CXCR5, BLR1 42 B, T sub, act T, neurons CXCL13 cell migration
CXCR6, Bonzo, T cell recruitment, HIV-1
CD186 CDw186 39 T subset (Th1), B subset, NK subset CXCL16, HIV-1, SIV coreceptor
CD191 CCR1 42 mono/mac, lympho, DC, stem cells CCL3, 5, 7, 8, 14, 15, 23 leukocyte chemotaxis
leukocyte chemotaxis, HIV-1
CD192 CCR2 38 mono, B, act T, DC CCL2, 7, 8, 12, 13, 16, HIV-1 coreceptor
CCL3, 5, 7, 8, 11, 14, 15, 24, 26, leukocyte chemotaxis, HIV-1
CD193 CCR3 45 eosino, baso, T subset, DC, microglia HIV-1 coreceptor
T cell chemotaxis, T cell homing
CD194 CCR4 63 T sub, Thymocytes, skin T, DC CCL17, CCL22 to skin
lymphocyte chemotaxis, HIV
CD195 CCR5 45 mono, T subset, DC HIV-1, CCL3, CCL4, CCL5 infection
CD196 CCR6 40 memory T, B, DC, Langerhans CCL20, β-defensin cell migration, HIV-1 coreceptor
T lymphocyte adhesion, thymo
CD197 CCR7, EBI-1 45 T subset, DC, B sub CCL21, CCL19 migration
CDw198 CCR8 40 mono, T subset, DC, HUVEC CCL1, vCCL1 cell migration, HIV-1 coreceptor
CDw199 CCR9 thymo, IEL, melanoma cells CCL25 cell migration, HIV-1 coreceptor
thymo, B, act T, endoth, keratinocyte downregulatory signal for
CD200 OX2 45-50 subset OX2R myeloid cell function
CD201 EPC-R 50 endoth, HSC protein C protein C activation
CD202b Tie2 (Tek) 145 endoth, stem cell subset angiopoietin angiogenesis, hematopoiesis
E-NPP3, PD-1b, clearance of extracellular
CD203c PDNP3, B10 130,150 baso, mast, megakar, tumor tissue nucleotides nucleotides
CD204 MSR 220 macrophages LDL, LPS, lipoproteins LDL uptake, host defense
DC, thymic epith, BM stromal, low on endocytosis, enhances Ag
CD205 DEC-205 205 T, B, NK and mono presentation
mac, mono, inflammatory dendritic
CD206 MMR 175 epidermal cells mannosylated Ag endocytosis
facilitates Ag recognition and
CD207 Langerin 40 Langerhans, DC uptake
CD208 DC-LAMP 70-90 act DC, type II pneumocytes
Ag endocytosis and
mannose glycoproteins, HHV-8, degradation, attachment of HIV
CD209 DC-SIGN 44 DC subset measles virus, Hepatitis C virus and some other viruses
IL-10R, IL-10R1, IL- T, B, NK, mono/mac, thymo (low), act
CDw210a 10Ra 90-110 neutrophils IL-10 receptor for IL-10
IL-10R2, CRF2-4, IL- T, B, NK, mono, DC, liver, assoc w/IL-10R1, IL-22R1, IL-
CDw210b 10Rb 105 neutrophils 20R1, IL-28R1, IL-29R1 signaling
assoc w/IL-12Rb2 or IL-23R,
CD212 IL-12Rb1 110 act T, NK, mac binds IL-12, IL-23 receptor for IL-12 and IL-23
CD213a1 IL-13Ra1 65 B, mono, mast, fibro, endoth IL-13 receptor for IL-13, signaling
CD213a2 IL-13Ra2 65 B, mono, epith IL-13, HSV receptor for IL-13
B, NK, fibro, epith, T, mono/mac,
CD217 IL-17R, CDw217 128 gran IL-17 receptor for IL-17
IL18Rα, IL-1Rrp1, T subset (Th1), B subset, NK, mono,
CD218a CDw218a 60-100 gran, endoth, DC IL-18,assoc w/ IL-18Rβ binds IL-18, signal transducion
IL18Rβ, IL-1RcPL, NK cells, T subset, mono, endoth,
CD218b CDw218b 64-66 DC assoc w/ IL-18Rα signal transduction
CD220 Insulin receptor 140, 70 leuko, fibro, endoth, epith insulin receptor for insulin,metabolism
signaling, cell proliferation/
CD221 IGF-IR 135 leuko and variety of non-hemato cells insulin differentiation
assoc w/ CD87, plasminogen, activates latent TGFb, cell
lympho, mono, gran, fibro, myocytes, proliferin, LAP, IGFII, M6P, LIF, adhesion, migration,
CD222 M6P-R, IGF-IIR 230,250 embryonic tissue HSV angiogenesis
negative regulation of T cell
CD223 LAG-3 70 act T, act NK MHC class II molecules expansion and homeostasis
glutathione, leukotriene C4,
glutanthione S-conjugates, assoc inhibits apoptosis, cellular
g-glutamyl T sub, B sub, mac, endoth, HSC, w/ CD19, CD21, CD37, CD53, detoxification and leukotriene
CD224 transpeptidase, GGT 27, 62-68 renal tubular cells, pancreas CD81, CD82 biosynthesis
complexed with lymphocyte activation and
CD225 Leu-13 17 leuko, endoth CD81/CD19/CD21 development
DNAM-1, PTA-1, T sub, NK, mono, platelets, B sub,
CD226 TLiSA1 65 thymocytes, act HUVEC CD155, CD112, assoc. w/ LFA-1 costimulation, adhesion
epith, stem cell subset, mono, act T,
CD227 MUC-1, EMA, mucin 1 300 DC CD54, CD169, selectins cell adhesion and signaling
melanoma cells, epith, brain, skeletal
CD228 MTf, p97 80-97 and heart muscle iron Fe transport
CD229 Ly-9 100, 120 T, B, thymo, DC CD229 adhesion, costimulation
hemato and non-hemato cells, prevents cells from apoptosis,
CD230 Prion protein 35 neurons stem cell renewal
T-ALL and neuroblastoma cells,
CD231 TALLA-1, A15 28-45 neurons
CD232 VESP-R 200 B, mono, gran, NK, act T, DC CDw108, poxvirus A39R cell differentiation and migration
CD233 Band3 95-110 eryth, kidney anion exchanger
eryth, endoth, neurons, epith, CXCL1, 5, 8; CCL2, 5, 7, malaria chemokine decoy receptor,
CD234 DARC, Fy, Duffy 35-45 cerebellum parasite malarial parasite receptor
hepatitis A virus, babesia, P. parasite receptor, cell
CD235a Glycophorin A 36 erythrocytes falciparum aggregation
hepatitis A virus, babesia, P. parasite receptor, cell
CD235ab Glycophorin A/B 20 erythrocytes falciparum aggregation
parasite receptor, cell
CD235b Glycophorin B 20 erythrocytes babesia, P. falciparum aggregation
CD236 Glycophorin C/D 30-40 eryth, stem cell subset Gerbich Antigen
CD236R Glycophorin C 40 eryth, stem cell subset P. falciparum BAEBL Gerbich Antigen
CD238 Kell 93 eryth, hemato progenitors endothelin-3 endothelin-3 converting enzyme
erythrocyte differentiation and
CD239 B-CAM 90 eryth, fibro, inducible in epith laminin trafficking
CD240CE Rhesus 30CE 30-32 erythrocytes
CD240D Rhesus 30D 30-32 erythrocytes
Rh antigens complex with CD47,
CD241 Rhesus 50 50 erythrocytes LW, glycophorin B
CD11a, b; CD18; CD49b, d, e,
CD242 ICAM-4 37-43 erythrocytes CD51 adhesion, LW blood group
ion pump, regulates drugs
MDR-1, P-gp, gp170, stem cells, multi-drug resistant tumor toxic xenobiotics, many anti- uptake, distribution, and
CD243 ABC-B1 170 cells cancer drugs elimination
stimulates NK activation,
CD244 2B4 66 NK, T subset, baso, mono CD48 costimulates T cells
signal transduction,
CD245 p220/240 215-245 T, B, NK, mono, gran, platelets costimulation
receptor for tyrosine kinase,
ALK, Ki-1, Anaplastic some T cell lymphomas, endoth, regulates cell growth and
CD246 lymphoma kinase 200 some neural cells midkine apoptosis
component of CD3/TCR complex, Ag recognition and signal
CD247 CD3z, Zeta chain, CD3z 16 T, NK binds ZAP-70 transduction
CD248 TEM1, Endosialin 165 embryonic endoth, tumor endoth angiogenesis
APA, ENPEP, gp160, assoc. w/ angiotensin II and converts angiotensin II to
CD249 EAP 160 epith, endoth cholecystokinin-8 angiotensin III
CD252 OX40L, TNFSF4 34 DC, act B, endoth, mast OX40 costimulation
TRAIL, APO2L,
CD253 TNFSF10 40 act T, NK DR4, DR5, DcR1, DcR2 apoptosis
TRANCE, RANKL, T-B and T-DC interaction, bone
CD254 TNFSF11 40 act T, stromal cells, osteoclasts RANK development
APRIL, TALL-2,
CD256 TNFSF13 38 leuko, pancreas, colon TACI, BCMA T and B cell proliferation
BLYS, BAFF, T, B cell growth and
CD257 TNFSF13b, TALL-1 34 act mono, DC TACI, BAMA, BAFF-R development
costimulation of T cells, induces
CD258 LIGHT, TNFSF14 29 act T, act mono HVEM, LTβR apoptosis
TRAIL-R1, DR4,
CD261 TNFRSF10a 56 act T, some tumor cells TRAIL (CD253) induces apoptosis
TRAIL-R2, DR5, leuko, heart, placenta, liver, tumor
CD262 TNFRSF10b 55 cells TRAIL (CD253) induces apoptosis
TRAIL-R3, DcR1, low level in most tissues, negative in inhibits TRAIL-induced
CD263 TNFRSF10c 65 most tumor tissues TRAIL (CD253) apoptosis
TRAIL-R4, DcR2, low level in most tissues, negative in inhibits TRAIL-induced
CD264 TNFSF10d 35 most tumor tissues TRAIL (CD253) apoptosis
TRANCE-R, RANK,
CD265 TNFRSF11a 97 DC, act mono TRANCE (CD254) receptor for TRANCE
TWEAK-R, Fn14,
CD266 TNFRSF12a 14 endoth, epith, keratinocytes TWEAK (CD255) regulates apoptosis, proliferation
CD267 TACI, TNFRSF13b 32 B, myeloma cells BAFF, APRIL inhibits B cell proliferation
B cell survival and maturation, T
CD268 BAFFR, TNFRSF13c 19 B, T subset BAFF cell activation
CD269 BCMA, TNFRSF17 B, plasma cells BAFF, APRIL plasma cell survival
low affinity receptor for NGF,
NGFR (p75), p75NGFR, neuronal cells, Schwann cells, induces apoptosis,
CD271 p75NTR, TNFRSF16 75 melanocytes, B, mono, keratinocytes NGF, BDNF, NT-3, NT-4 embryogenesis, hair growth
T (upregulated upon act), B act, NK,
CD272 BTLA 33 mac, DC HVEM inhibition of T cell function
CD273 B7DC, PDL2 25 DC, act mono PD-1 costimulation, inhibition
CD274 B7H1, PDL1 40 T, B, NK, DC, mac, epith PD-1 costimulation, inhibition
B7H2, ICOSL, B7RP1,
CD275 B7h 40 act mono, mac, DC ICOS costimulation
DC, act mono, act T, act B, act NK, may play role in costim or
CD276 B7H3 45, 110 epith inhibition
CD277 BT3.1, BTN3A1 T, B, NK, mono, DC, endoth BT3.1-R T cell activation
CD278 ICOS 47-57 act T, thymo subset B7H2 (CD275) T costimulation
CD279 PD1 50-55 act T, act B, thymo subset CD273, CD274 T tolerance, negative regulation
TEM22, ENDO180, fibro, endoth, mac, osteoclasts, remodeling, uptake and
CD280 uPARAP 180 osteocytes, chondrocytes collagen, assoc. w/ uPAR degradation of collagen
CD281 TLR1 90 mono, mac, DC, keratinocytes assoc. w/ TLR2, lipoproteins regulates TLR2 function
innate immune response to
mono, gran, mac, DC, keratinocytes, lipoproteins, glycans, assoc. w/ some bacteria and mycoplasma
CD282 TLR2 86 epith TLR1 or TLR6 pathogens
innate immune response to viral
CD283 TLR3 120 DC, fibro, epith dsRNA pathogens
assoc. w/ MD2 and CD14, binds innate immune response to
CD284 TLR4 110 mono, mac, endoth, epith LPS gram-negative bacteria
innate immune response to
lipoproteins, glyans, assoc. some bacteria and mycoplasma
CD286 TLR6 90 mono, mac, gran, DC, epith w/TLR2 and CD36, pathogens
anti-viral immune response,
brain development,
CD288 TLR8 110 mon, mac, DC, neurons, axons ssRNA hematopoiesis
innate immune response to
CD289 TLR9 110 pDC, B, mono CpG DNA bacteria or virus
CD290 TLR10 90 B, pDC assoc w/TLR1, 2 and 10 coreceptor with TLR2
mesenchymal cells, epith, bone
progenitor, neurons, chondrocytes, kinase, hair morphogenesis,
CD292 BMPR1A, ALK3 55, 80 skeletal muscle, cardiac myocytes BMP2, 4, 7, GDF-5 antiapoptosis, embryogenesis
mesenchymal cells, bone progenitor, kinase, regulates cartilage
CDw293 BMPR1B, ALK6 55, 80 chondrocytes, epith, heart, kidney BMP2, 4, 7, GDF-5 formation
regulates immune and
inflammatory response, induces
Th2 cells, eosino and baso
CD294 CRTH2, DP2, GPR44 55-70 Th2 cells, baso, eosino PGD2 migration
regulates fat metabolism,
hemato cells, heart, placenta, liver, proliferative/antiapoptotic T cells
CD295 LEPR, OB-R 132 kidney, pancreas leptin and hemato precursors
transfers ADP-ribose to target
proteins, regulates cellular
CD296 ART1 36 neutro, heart, skeletal muscle PDGFβ, integrins, defensin metabolism
Dombrock+ RBC, mono, mac, baso, metabolism, dombrock blood
CD297 ART4 36 endo, intestine, ovary group antigen
non-catalytic component of
broad, highly expressed in CNS, ATPase coupling exchange of
CD298 ATP1B3 32 testis dimerizes with ATPα1, 2 or 3 sodium and potassium ions
ICAM-3, HIV gp120, Hepatitis C T cell trafficking, HCV, EBOV
CD299 DC-SIGNR, L-SIGN 45 endoth of liver and lymph nodes virus, ebolavirus and HIV infection
CMRF35H, CMRF-35- mono/mac, neutro, DC, NK, mast
CD300a H9, IRp60 34 cells, T and B subsets inhibitory receptor
mono/mac, neutrophils, DC, NK, T
CD300c CMRF35A 25 and B subsets
CD300e CMRF35L1 mono/mac, DC subset
carbohydrate with Gal/GalNAc cell adhesion, macrophage
CD301 MGL1, CLECSF14 42 mac, immature DC structure migration, cellular recognition
CD302 DCL1 30 mono/mac, DC
Ag capture, inhibition of
CD303 BDCA2 38 plasmacytoid DC interferon α/β production
BDCA4, neuropilin-1, VEGF165, SEMA3A, complexed angiogenesis, DC-T cell
CD304 NRP1 103 DC, T, neurons, endoth with plexin-1 interaction, neuritogenesis
inhibits cellular activation and
CD305 LAIR1 31 T, B, NK, DC, mono/mac Ep-CAM (CD326) inflammation
inhibits cellular activation and
CD306 LAIR2 16 T, mono Ep-CAM (CD326) inflammation
B, high on germinal center light zone Ig receptor, may play a role in B
CD307 IRTA2, FcRH5, FCRL5 83-107 B cells IgG and IgA (weakly) cell activation and neoplasia
endoth, primitive stem cells, some
CD309 VEGFR2, KDR 195/235 tumor cells VEGF-A, E, C and D angiogenesis
chondroitin sulfates, involved in immune and
CD312 EMR2 90 mac, act mono, DC, liver, lung glycosaminoglycan, CD55 inflammatory response
CD314 NKG2D 42 NK, CD8+ T subset, g/d T, Mac MICA, MICB, ULBP-1,2,3 NK activation
megakar, hepato, epith, endoth,
CD315 CD9P-1, FPRP, EWI-F 135 weak on B and mono assoc. w/ CD9 and CD81
assoc. w/ CD9, CD81, and
CD316 EWI-2, PGRL 62-78 T, B, NK, hepato KAI1/CD82 inhibits tumor cell metastsis
plasma cells, lymphoplasmacytoid may play a role in pre-B cell
CD317 BST2 30-36 cells, stromal cells, fibro, pDC growth
hemato stem cells, epith, some tumor
CD318 CDCP1, SIMA135 80/140 cells adhesion
activates NK cytotoxicity,
CD319 CRACC, CS1 66 NK, most T, act B, mature DC CD319 adhesion
CD320 8D6, NG29 follicular dendritic cells stimulates B cell growth
cell adhesion, leuko migration,
JAM1, JAM, JAM-A, epith, endoth, leuko, platelets, eryth, epithelial barrier maintenance,
CD321 F11R 35-40 lung, placenta, kidney PAR3, LFA-1, reovirus platelet activation
PAR-3, a4b1 integrin, JAM3, JAM- cell adhesion, lymphocyte
CD322 JAM2, VE-JAM 48 endoth, HEV in tonsils, heart 2 homing
cell-cell, cell-matrix adhesion;
epith, keratinocytes, trophoblasts, CD103, E-cadherin, PS1, tumor suppression; cell growth
CD324 E-Cadherin, CDH1 120 platelets catenins, internalin and differentiation
N-Cadherin, CDH2 neurons, skeletal and cardiac cell-cell, cell-matrix adhesion;
CD325 CDw325 130 myocytes, fibro, epith, pancreas, liver N-cadherin, catenins, FGFR, PS1 cell growth and differentiation
Ep-CAM, MK-1, KSA, inhibit cellular activation and
CD326 EGP40 40 epith,low on thymo and T, tumor cells LAIR-1, LAIR-2, Ep-CAM inflammation
Siglec-6, OB-BP-1,
CD327 CD33L1, CDw327 B, placenta trophoblasts, gran leptin, sialyl-Tn cell adhesion
Siglec-7, p75/AIRM,
CD328 CDw328 65-75 NK, T subset, mono, gran GD3, LSTb inhibits NK and T cell activity
mono; sub of NK, B, T and neutrophil
CD329 Siglec-9, CDw329 cells; hepato, myeloid leukemia GD1a, LSTc inhibits immune response
broad, epith, endoth, fibro,
FGFR1, FLG, FLT2, N- 60, 110- mesenchymal, cardiac myocytes,
CD331 SAM 160 fetal tissue aFGF, bFGF, K-FGF cell growth, limb development
brain, liver, prostate, kidney, lung, limb induction, craniofacial
CD332 FGFR2, BEK, K-SAM 135 spinal cord, fetal tissues aFGF, bFGF, K-FGF, FGF-6 development
brain, kidney, testis in adult, brain, limb induction, craniofacial
CD333 FGFR3, ACH 115-135 small intestine in fetus aFGF development
liver, kidney, lung, pancreas, lympho, bone and muscle development,
CD334 FGFR4, TKF 88-110 mac aFGF, FGF19 cancer progression/metastasis
viral hemagglutinins, heparan
CD335 NKp46, NCR1, 46 NK sulfate proteoglycans NK activation
viral hemagglutinins, assoc. w/
CD336 NKp44, NCR2 44 activated NK DAP12 NK activation
CD337 NKp30, NCR3 30 NK heparan sulfate proteoglycans NK activation
liver, kidney, intestine, lung,
endothelium, melanoma, placenta,
ABCG2, ABCP, MXR, side population of stem cells, certain absorption and excretion of
CD338 BCRP, CDw338 72 drug resistant tumor cells some xenobiotics certain xenobiotics
BM stromal, thymic epith, endoth, cell-fate decisions in
Schwann cells, keratinocytes, ovary, hematopoiesis, cardiovascular
CD339 Jagged-1, Jag1 134 prostate, pancreas, placenta, heart Notch1, 2, and 3 development
epith, endoth, keratinocytes, sub of
CD34+ stem cells, fetal mesodermal
and extraembryonic tissues, over- cell growth and differentiation,
CD340 Her-2, Neu, erb-B2 185 expressed on many maliganant cells gp30 tumor cell metastasis
cell proliferation and
epith, endoth, mesenchymal, myeloid differentiation, embryonic
Frizzled-4, FZD4, EVR1, progenitors, neuronal progenitors, development, retinal
CD344 FEVR 48-53 intestinal neuronal cells Norrin, Wnt proteins angiogenesis
mesenchymal stem cells, neural
precursor, adult brain, fetal brain, B cell development,
testis, kindey, eye and pancreas, hippocampal development,
CD349 Frizzled-9, FZD9 64 some tumor cells Wnt-2, Wnt-8 tissue morphogenesis
brain, embyro, kidney, liver,
CD350 Frizzled-10, FZD10 65 pancreas, placenta, some tumor cells Wnt proteins limb development
Contact: techserv@biolegend.com.
Intracellular Interaction
Fyn, Lck, SH3KBP1, Sp1,
MAD
Syk, ZAP-70, Lck, SHC,
Grb4, PI3Ka, NCK1
Lck
Fyn, Lck, ZAP-70, PKCa,
PKCb1, PKCg, PI3Ka,
SHP1
PI3Ka, PI4Ka
Lck, KAT
PKCa
Lyn, SHC, PI3Ka, PI3Kb
RANBP9
IRAK1
Lck, ZAP-70, SHC
Syk, FAK, ILK, RACK1,
RANBP9, PKCa, PKCd,
PKCe, PYK2
Fyn, LCK, Syk, BTK,
VAV1, VAV2
Fyn, CK21A, CK2A2
p53
Lyn, Syk, SHIP1, SLP76,
Grb2, PI3Ka, PLCg1,
SHP1
Fyn
Fgr, Lyn
STAT3, NFkB1, STAT5B
TRAF2, TRAF3, TRAF5,
Siva
ITK, Grb2, PI3Ka, PI3Kb,
PI3Kg, PLC-g1
PKCa, PKCe, RACK1,
FAK, 14-3-3b, ILK,
RhoGAP5, PIK4a
ALK, TRAF1, TRAF2,
TRAF3, TRAF5
Lck, Fyn, c-Src, Hck, c-
Yes, Csk, PI3Ka, PLC-g1
Fyn, Hck, Lyn, Syk, LAT,
BLK, SHC
c-Src, SHP1, SHP2
PKCd, CRKL
Fyn, Lyn, c-Yes, c-Src
Lck
JAK3, PI3Ka, TRAF1-3,
TRAF5-6, Ku80
GRB2
14-3-3 ζ, PKACA
14-3-3 ζ
Fyn
Csk, Fyn, Lck, Rho, PKN
Fyn, Lck, Lyn, RasGAP,
SHP-1, SLP76, Grb2
c-Yes, c-Src
Fak
Lck
PRKACA, HIC5
RHOGap5
Fyn, SHC, PKCd, Grb2
Fyn, Fak
Fyn, Lck
Fyn, Fak
c-Src
c-Src, SHC1, AKT1, Talin,
FAK, Paxillin
PLC-g1, SHP2, FAK,
Paxillin
Grb2
PI4Ka
Hck, Syk, CRKL, LAT
c-Src, SHP2, SHP1,
MAP3K10, SHC, Paxillin
c-Src, CKI-alpha-like
Rab5B, TCRz
Grb2, SHP1, BLNK
b-Actin, Fibronectin 1,
Laminin A
Lck, Fyn, Lyn, Syk, SHP1,
BLK
Lck, Fyn, Lyn, FAK, Syk,
ZAP-70, Shp1, BLK
EAT2, SAP
SHP1
SHP1, SHP2
Fyn, Hck, JAK1, TYK2
Lyn
Fyn, Lck
c-Src, Rap, JIP, SHC,
PRKACA
RANBP1, ARHGAP15
DAP12
Fyn, Lck, FADD, Daxx,
RIP, FAF1, PKCa, SHP1
Moesin
Fyn, c-Yes, FAK, Grb2,
PKCa, PKCd, 14-3-3b, 14-
3-3t
Moesin, Ezrin
IRS2, SHC, SHP2,
SOCS1, JAK2
AF6, PARD3
AF6
AF6
Lck, Lyn, Hck, Syk, Grb2,
SHIP1, Jak1, Jak2
Fyn, c-Yes, Lyn, Cbl,
Grb2, RasGAP, SHIP1,
SHIP2
Lyn, IKKa, IKKb
Lck, Fyn, Lyn, c-Src, c-
Yes, HCK, Tec, BTK
PLC-g1, SHP1, SHP2,
ERK2
Jak1, Jak2, SOCS1,
STAT1, SHP2
FAK, Jak1, Jak2, SHP1,
SHP2, STAT1, TRAF1,
TRAF2,
CK1, STAT1, TRAF1-3
Lck, JAK1, JAK3, STAT1,
STAT3, STAT5A,
STAT5B, SOCS1
Vav1, Tec, CISH
SHC, SHP1, SHP2,
RACK1, SHIP, JAK1,
IRS1, IRS2
JAK1, JAK2
c-Src, STAT3, WWP1,
WWP2
Fyn, Lyn, JAK1, PTK2B
14-3-3 ζ, JAK1
TYK2, Vav1, SHP1,
SHP2, JAK1, JAK3,
SOCS3, STAT3
Lck, Syk, Lyn, Fyn, JAK1,
JAK2, STAT1, STAT3
JAK1, JAK3, SHB, SHC,
STAT1, STAT5A
TRAF1-5, Siva
SHC, NICK1, Grb2, SHP1,
FLT3, SOCS1
c-Src, c-Yes, PI3Ka,
PLCg1, Grb2, 14-3-3
proteins (β, ε, σ, ζ, θ, η),
JAK2
TRAF 1-3
CASK
PLCg1, CRK, Grb2,
STAT1, STAT3, STAT5A,
STAT5B, JAK1
c-Src, Csk, SHC, SHP2
Fyn
LAT, PLC-g1
Fyn, Fgr, SHP2, SLAM,
EAT2
Fyn, Lck, Lyn, STAT5A,
STAT5B, Jak2, PI3Ka,
SHP2
p53
Lck
CDK3
SHP1, SHP2
SHP1, SHP2
SHP1
Syk
PKCa, CSNK2B
Grb4, SHP2, PLCg1, SHC
ERK1
CSNK2A1, RANBP9
SHP1, SHP2, JAK2
DAP12
Fyn, Lck, FADD, Daxx,
FAF1, c-FLIP. PKCa,
SHP1
FAK, Jak2, Jak3, STAT1,
STAT2, STAT3, STAT5B,
SOCS1
Jak1, STAT1, STAT3
Jak2
Fgr, Hck
Lck, FAK, Jak1, Jak2,
STAT1, STAT3, STAT5B
Fyn, Grb2, Lck, Lyn, TEK,
SOCS1, STAT5A,
STAT5B
HSP70
JAK1
JAK1
STAT4
TYK2
c-Src, Csk, Cbl, FAK,
JAK1, JAK2, STAT5A,
STAT5B
c-Src, ASK1, CRK, Csk,
Jak1, Jak2, CRKL, STAT3
Fyn
Lck, c-Src, ZAP70, Grb2,
SOS1
SH2D1A, EAT2
BIP, Grb2
Lyn, Syk
Laminin A5
LAT, EAT2, SH2D1A
ALK, SHC, JAK3, PLCg1,
IRS1
Lck, Fyn, ZAP-70, Csk,
SHP1, JAK3, STAT5A,
STAT5B
TRAF2
c-Src, AKT1, ERK1, ERK2,
TRAF6
TRAF2, TRAF3, SMAC
BCL10, Caspase 8,
Caspase 10, FADD, c-
FLIP, BTK
BCL10, Caspase 8,
Caspase 10, FADD, c-
FLIP, BTK
Rap1a
c-Src, Cbl, CblB, Grb2,
MAP3K7, TRAF1-3,
TRAF5-6, TAB2
TRAF1-3
TRAF2, TRAF5-6
TRAF1-3
ERK1, ERK2, Grb2,
PRKACB, SHC, TRAF2,
TRAF4, TRAF6
SHP1, SHP2
RIP2, TOLLIP, PI3Ka, H-
Ras, MYD88
TRIAD3, MYD88, TRAF6,
MAP3K7, TAB2
Syk, BTK, IRAK2, MYD88,
RIP2, TOLLIP, TRIAD3,
MAPK8IP1
BTK, TRIAD3, H-Ras,
MAPK8IP3
TAB1
PAK1, RhoD, SH3KBP1,
SOCS6, SMAD6, SMAD6,
SMAD7
Csk, SHP2
Fyn, c-Yes, c-Src, Grb2,
Grb10, NCK1, Cbl, STAT1
DAP10, DAP12
c-Src, PKCd
PKCa, CSNK2A1, CASK,
PTPB
GSK3b, CSNK2A1, RICS,
IRS1
PI3Ka, RICS
Grb2, SHP2, TRAF4
CRK, Grb2, Grb4, Grb14,
PI3Ka, PI3Kb, PLCg1,
SOS1
Lyn, Fyn, Cbl, PLCg1,
PAK1, PTK2B
Grb2, PTK2B, STAT1,
STAT3
PLCg1, STAT1, STAT3
DAP12
PLC-g1, STAT1, STAT3