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Red Wine Prevents Brain Oxidative Stress and Nephropathy in

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					,.la te zoñuM ;3991 ,.la te nitsugA( ZTS yb decudni etats                                                       se.ocu@polom1bb :liam-E
citebaid dna sserts evitadixo eht noitaunetta rof detseggus                                    92 28 12 759 43 :xaF ;86 28 12 759 43 :leT
neeb evah sa llew sa ,)2002 ,lheB dna nnamsoM( snoitidnoc                                  .desserdda eb dluohs ecnednopserroc mohw oT*
evitarenegedoruen latnemirepxe fo yteirav a tsniaga snoruen tcetorp
ot nwohs neeb evah sregnevacs lacidar eerf ,yllanoitiddA
                        .)1002 ,iksledukzS( SOR fo noitcudorp
eht fo snaem yb stceffe suoireteled rehto sa llew sa ,AND fo                                                nicotozotpertS ,eniw
noitatnemgarf eht ni devlovni eb ot nwohs neeb sah nixot sihT          deR ,sserts evitadixO ,yhtaporhpeN ,setebaiD :sdrowyeK
.)7691 ,.la te rreH( senegomorhca secymotpertS morf detalosi
tsrif saw taht etavired aeruosortin lanoitcnufonom a si ZTS                             .ksir cinegorehta dna aimeloretselohcrepyh
.)4991 ,.la te ziuR( syassa fo yteirav a ni cixotoneg si ZTS           tsniaga stcetorp ti sa llew sa ,ZTS yb decudni setebaid
,seitreporp cinegotebaid dna citoibitna sti sediseB .)4991 ,.la        dna yhtaporhpen citebaid ,sserts evitadixo niarb
te ziuR( sllec-β citaercnap no tceffe cixot sti hguorht slamina        tsniaga tceffe evitcetorp a sah eniw der taht detseggus
latnemirepxe ni sutillem setebaid ecudni ot desu netfo si dna          atad esehT .ZTS yb decudni segnahc eht detneverp
ytivitca citoibitna murtceps daorb sah )ZTS( nicotozotpertS            yltnacifingis eniw der htiw tnemtaerT .seitivitca esalatac dna
                                    .)4002 ,.la te slesseiB ;3002      xP-HSG ,DOS dna tnetnoc HSG eht desaerced ti saerehw
,.la te sebroF ;2002 ;4991 ,.la te slesseiB ;8891 ,yeldrebO(           ,yendik dna amsalp ,niarb eht ni stcudorp noitadixorep
yhtaporhpen dna )SNC( metsys suovren lartnec dna )SNP(                 dipil ni sa llew sa ,IA dna loretselohc latot ,aimecylg
larehpirep eht ni yhtaporuen citebaid fo tnempoleved eht ni            ,airunimubla ,airunietorp ,airusocylg fo slevel ni sesaercni
detacilpmi neeb sah sserts evitadixo decudni-aimecylgrepyH             tnacifingis desuac ZTS fo noitartsinimda ehT .doirep h
.)2002 ,.la te rednalsuA ;9991 ,eporhT dna senyaB ;6991                42 revo eniru ni esoculg dna snietorp ,nimubla fo noitercxe
,.la te onailfiuG ;6991 ,.la te bahaW ledbA ;5991 ,miK dna             eht dna ,setanegomoh laner dna niarb ni seitivitca
aH ;1991 ,.la te floW ;1991 ,senyaB ;0991 ,.la te tnuH ;8891           esalatac dna xP-HSG ,DOS dna HSG ,noitdixorep dipil
,yeldrebO ;8891 ,.la te polsyH( yretra larberec eht ot egamad          eht detamitse ew ,llew sA .seitivitca )xP-HSG( esadixorep
ralucsavorcim dna ,yhtaporuen ,yhtaporhpen ,yhtaponiter sedulcni       enoihtatulg dna )DOS( esatumsid edixorepus dna
hctiw fo rettal eht ,yhtapoignaorcim dna yhtapoignaorcam               )HSG( enoihtatulg decuder ,stcudorp noitadixorep dipil
otni dezirogetac yliramirp ,snoitacilpmoc citebaid reggirt taht        ,nilusni ,eninitaerc ,)NUB( negortin aeru doolb ,nietorp
smsinahcem lacigoloisyhpohtap suoremun dna sisenegohtap                latot ,)IA( xedni cinegorehta ,)c-LDH( loretselohc-LDH
htob ni elor a yalp SOR taht detroppus sah ecnedive                    ,loretselohc latot ,sedirecylgirt ,esoculg eht enimreted ot
latnemirepxE .slamina dna snamuh htob ni )SOR( seiceps                 redro ni knurt ralucsav kcen eht morf nekat erew selpmas
negyxo evitcaer fo noitcudorp desaercni na htiw detaicossa             doolB .star citebaid dna lamron htob ni yllaro nevig
si redrosid sihT .)0002 ,slesseiB dna nepsiG ;2991 ,llaCcM(            saw eniw der ,noitcejni retfa skeew ruof dna erofeb skeew
snoitacilpmoc larutcurts dna lanoitcnuf ynam htiw detaicossa           owT .)gk/gm 05( ZTS fo noitcejni yllanotirepartni elgnis
redrosid cilobatem suoires tub nommoc a si sutillem setebaiD           a htiw star ratsiW ni decudni saw setebaiD .star citebaid
                                                                       decudni-)ZTS( nicotozotperts ni yhtaporhpen dna sserts
                                                   noitcudortnI        evitadixo niarb no eniw der fo stceffe eht deiduts evah eW
                                           5002 yaM 81 detpeccA ,5002 lirpA 8 devieceR
                    niapS ,abodroC ,aifoS anieR oiratisrevinU latipsoH ,aigolotaP ed otnematrapeD ,odagiH ed dadinU§
                             niapS ,abodroC ,aifoS anieR oiratisrevinU latipsoH ,socinilC sisilanA ed oicivreS‡
                niapS ,abodroC ed dadisrevinU ,anicideM ed datlucaF ,raluceloM aigoloiB y acimiuqoiB ed otnematrapeD†
                                       zenuT caasI dna adeñatsaC-zoñuM .R nauJ
                                           †                    §
                     , ecnalajuB adalucamnI , zoñuM .C airaM , socraB tarrestnoM ,* allitnoM ordeP
                      †                            †                    ‡                         ,†
                                    staR citebaiD decudni-nicotozotpertS
              ni yhtaporhpeN dna ssertS evitadixO niarB stneverP eniW deR
                                                 445-935 .pp ,5002 rebmetpeS ,5 .oN ,83 .loV ,ygoloiB raluceloM dna yrtsimehcoiB fo lanruoJ
                                          .nicotozotperts sv 50.0 < p ;nicotozotperts sv 100.0 < p ;lortnoc sv 50.0 < p ;lortnoc sv 100.0 < p
                                                                   d                            c                    b                      a
                                                                                                         .star evif fo MES ± snaem era seulaV
      d
       5.2 ± 51.              b
                                 9.6 ± 62.               7.3 ± 31.             2.1 ± 6.6                         )h 42/g( nietorp latoT
      d
       1.0 ± 2.0              b
                                 2.0 ± 4.0               1.0 ± 1.0             1.0 ± 1.0                            )h 42/gm( nimublA
      c
       1.1 ± 2.2              0 66 ± 971
                              a
                                                         9.2 ± 2.1             3.1 ± 9.1                             )h 42/gm( asoculG
                                                                                                                                     enirU
      c
       3.0 ± 7.0              a
                                 4.0 ± 3.1               1.0 ± 5.0             2.0 ± 7.0                                              IA
       0
        05 ± 43                   0
                                   4 ±13                 02 ± 43               03 ± 13                                  )Ld/gm( C-LDH
       0
        61 ± 46               0
                                  71 ± 65                06 ± 55               21 ± 75                           )Ld/gm( sedirecilgyrT
       0 5 ± 06
              b
                                 0 9 ± 96
                                  a
                                                         05 ± 25               07 ± 25                       )Ld/gm( loretselohc latoT
                                                                                                                                     mureS
      c
       5.0 ± 5.6              a
                                 6.0 ± 9.2               6.0 ± 3.4             6.0 ± 6.4                                  )L/U( xP-HSG
      c
       2.0 ± 2.4              a
                                 3.0 ± 3.3               6.0 ± 1.6             3.0 ± 9.5                                      )L/U( DOS
      c
       1.0 ± 3.0              a
                                 1.0 ± 2.0               1.0 ± 4.0             1.0 ± 4.0                                   )L/lomn( HSG
      c
       5.0 ± 1.6              a
                                 1.1 ± 2.9               7.0 ± 9.6             6.0 ± 3.6       )L/lomn( stcudorp noitadixorep dipiL
      0
       1.0 ± 5.6              0
                                 8.0 ± 9.5               2.0 ± 5.6             2.0 ± 4.6                           )Ld/g( nietorp latoT
      0
       1.0 ± 7.0              0
                                 1.0 ± 7.0               1.0 ± 6.0             1.0 ± 6.0                            )Ld/gm( eninitaerC
     .. 07 ± 44
          0
                               ...04 ± 44                03 ± 04               06 ± 83                                    )Ld(/gm( NUB
     0 2.0 ± 0.2
      c
                              0 1.0 ± 23.0
                              a
                                                       .5.0 ± 9.2            ..4.0 ± 2.3                                 )Lm/gn( nilusnI
     0 81 ± 251
       c
                              0 74 ± 344
                              a
                                                        .21 ± 241             001 ± 821                                )Ld/gm( esoculG
                                                                                                                                    amsalP
    nicotozotperts           nicotozotpertS             eniw deR                lortnoC
     + eniw deR
      tar eht ni sserts evitadixo amsalp dna noitercxe yraniru ,eliforp dipil ,sretemarap citebaid no ZTS dna eniw der fo stceffE .1 elbaT
                                                                                                      .mutibil da retaw dna )niapS ,anolecraB
                                                    .)niapS ,dirdaM(      , aniruP( doof htiw dedivorp erew dna )h 00 : 80 ta no sthgil
                                                                           ®
niapS SIC yb deilppus tik recart a sa nilusni-]I [ cificeps-tar gnisu
                                               521
                                                                          ,elcyc krad h 21/thgil h 21( noitanimulli ,)C 32-02( erutarepmet
                                                                                                                           o
yassaonummioidar yb derusaem saw amsalp ni slevel nilusnI                 fo snoitidnoc dellortnoc ot detcejbus erew yehT .niapS ,anolecraB
          .rezylanaotua 719 ihcatiH-ehcoR a no )dnalreztiwS ,lesaB        ,reviR selrahC morf desahcrup erew yduts eht fo gninnigeb
,noitaroproC scitsongaiD ehcoR( stik laicremmoc gnisu denimreted          eht ta g 052 -032 neewteb gnihgiew star ratsiW elam dlo-htnom
saw esoculg yraniru dna amsalP etats citebaid fo noitaulavE               eerhT .niapS ,abodroC fo ytisrevinU eht fo eettimmoC scihteoiB
                                                                          yb devorppa erew dna ,8891/322 .D.R eht dna )CCE/906/68( 6891
                   .esalatac dna ,DOS ,xP-HSG ,HSG ,noitadixorep          rebmevoN 42 fo evitceriD licnuoC seitinummoC naeporuE eht htiw
dipil yendiK -3 elbaT ;esalatac dna DOS ,xP-HSG ,HSG                      ecnadrocca ni erew serudecorp dna serac lamina llA slaminA
,noitdixorep dipil niarb -2 elbaT .nietorp latot dna nimubla ,esoculg
:eniru ;xedni cinegorehta dna loretselohc-LDH ,sedirecylgirt              .)niapS ,abodroC ,allitnoM( .A .S esuoheraW sayemO eht yb detanod
,loretselohc latot :mures ;xP-HSG dna ,DOS ,HSG ,noitadixorep             saw yduts eht ni desu eniw der ehT .elbaliava edarg laicremmoc
dipil ,nietorp latot ,eninitaerc ,NUB ,nilusni ,esoculg :amsalp -1        tsehgih eht fo erew dna )ASU ,siuoL .tS( .oC lacimehC amgiS morf
elbaT :dedulcni denimreted sretemarap lacimehcoib ehT .detcelloc          desahcrup erew stnemegaer dna ZTS ehT stnemegaer dna sgurD
yendik dna ,niarb ,doolb htiw decifircas erew slamina eht ,ecifircas
ot roirp yad eno detcelloc erew selpmas eniru doirep latnemirepxe                                              sdohteM dna lairetaM
keew xis eht retfA .doirep latnemirepxe eht tuohguorht )g001
/lack 103 ygrene elbasilobatem dna gk/g 895 etardyhobrac ;gk/g
63 erbif edurc ;gk/g 23 staf ;gk/g 081 nietorp edurc :noitisopmoc(                          .star fo niarb eht ni sserts evitadixo decudni
wohc tar )niapS ,anolecraB( aniruP htiw def erew staR                     -nicotozotperts ni eniw der fo tceffe eht ta kool ot dengised
                                      ®
                                                  .skeew xis rof eniw     saw yduts tneserp ehT .sserts evitadixo larberec ni segnahc
der deviecer 2 puorG .noitcejni ZTS eht retfa skeew ruof rof yliad        decudni-setebaid tneverp dluow )niapS ,abaodroC ,seliroM
dna noitcejni ZTS eht ot roirp skeew owt rof yliad deretsinimda           -allitnoM( eniw der noitanibmoc eht taht dezisehtopyh eW
                                                                                                         .)4002 ,. la teallitnoM ;2002 ,. la
)yad/thgiew ydob gk 07/Lm 004( esod laro na saw tnemtaert
                                                                          te ubaS ;0002 ,elibatsetnoC dna iligriV ;9991 ,.     la teiciderT
eniw der ehT .thgiew ydob gk/gm 05 fo noitcejni .p.i elgnis
a saw tnemtaert ZTS ehT .detaert ZTS dna eniw der 4 puorG dna             ;7991 ,tnatsnoC( setebaid dna sserts evitadixo ,aitnemed
;detaert ZTS 3 puorG ;detaert eniw der 2 puorG ;lortnoc detaertnu         fo ecnedicni eht htiw detalerroc ylesrevni si eniw der fo
lamron 1 puorG :slamina evif fo spuorg ruof otni detarapes erew           noitpmusnoc etaredom taht decnedive evah seiduts latnemirepxe
star ratsiW dlo-htnom eerht )02( ytnewT slocotorp latnemirepxE            dna lacigoloimedipe ,llew sA .)8991 ,.     la te  allitnoM ;3991
                                                             .la te allitnoM ordeP                                                       045
detaluclac saw )IA( xedni cinegorehta ehT .rezylanaotua 719 ihcatiH     htiw dna esalatac fo noitartnecnoc eht ot lanoitroporp gnieb
-ehcoR a no )dnalreztiwS ,lesaB ,noitaroproC scitsongaiD ehcoR(         negyxo ralucelom dna retaw ot 2O2H fo noitatumsid fo etar eht
stik laicremmoc gnisu denimreted erew nimubla dna nietorp               htiw ,tnegaer sa desu saw )Mm 01( 2O2H .erutarepmet moor ta nim
latot fo slevel yraniru sa llew sa ,)c-LDH( loretselohc-nietorpopil            g
                                                                        01 rof × 000,1 ta degufirtnec neht erew setanegomoh ehT .)lm
ytisned-hgih dna sedirecylgirt ,loretselohc latot mures dna nietorp     000,1 ot pu edam ,retaw ni 4OP2HK g 18.6( reffub etahpsohp dloc
latot ,eninitaerc ,NUB amsalP detaulave sretemarap rehtO                -eci ni dezinegomoh erew yendik dna niarb ehT .mn 042 ta 2O2H
                                                                        rof noitisopmoced fo etar eht yb ,)4891( ibeA gniwollof deyassa
               .dradnats a sa nimubla mures enivob gnisu )6791(         saw esalataC .noitcarf losotyc llec eht ni derusaem saw esalataC
dohtem drofdarB eht yb denimreted saw noitartnecnoc nietorP                                                   ytivitca emyzne tnadixoitnA
                                              noitamitse nietorP
                                                                                                                                .mn 004 ta
                                   .mn 043 ta ecnabrosba mumixam        htgnelevaw ecnabrosba lamixam a sah hcihw enoiht cirohpomorhc
htiw ,esatcuder enoihtatulg fo noitartnecnoc gnitimil a yb dezylatac    a HSG htiw gniniatbo ,spets owt ni sdeecorp hcihw noitcaer
,+DAN ot HPDAN fo noitadixo eht no desab si yassa esadixorep            lacimehc a no desab si dohtem ehT .)ASU ,dnaltroP ,lanoitanretnI
                                        g
enoihtatulg ehT .Co4 ta nim 01 rof × 000,01 ta degufirtnec              SIXO( tik 004-HSG hcetyxoiB gnisu tuo deirrac saw tnetnoc HSG
neht erew setanegomoh ehT .etanegomoh a ecudorp ot )lm 000,2            .amsalp dna setanegomoh laner dna niarb htob ni denimreted saw
,emulov lanif ,retaw dellitsid fo lm 001 ni ninotigid gm 0.01 dna       tnetnoc )HSG ro enicylgnietsyclymatulg-ammag( enoihtatulg decudeR
retaw dellitsid fo lm 001 ni )ATDE( dica citecaartetenimaidenelyhte                                           tnetnoc enoihtatulg decudeR
gm 2.92 sulp ,0.7 Hp ,4OPH2K/4OP2HK M 1.0( reffub dloc-eci ni
dezinegomoh erew seussit ehT .)4891( dohtem relznuG dna éholF                                           .mn 685 ecnabrosba mumixam htiw
eht yb setanegomoh yendik dna niarb dna ,amsalp ni detaulave            erohpomorhc elbats a gnidleiy ,Co1 ± 54 ta slaneklayxordyh-4 dna
saw ytivitca )9.1.11.1 :.C.E ;xP-HSG( esadixorep enoihtatulG            edyhedlaidnolam stcudorp noitadixorep dipil eht htiw stcaer hcihw
                                             .mn 065 ta ecnabrosba      tnegaer cinegotamorhc a sesu tik ehT .)ASU ,dnaltroP ,lanoitanretnI
mumixam htiw ,rotareneg edixorepus yb noitcuder )TBN( milozartet        SIXO( tik 685-OPL hcetyxoiB eht gnisu stcudorp noitadixorep
eulbortin fo noitcuder eht tibihni ot DOS fo ytiliba eht no desab       dipil rof detset yletaidemmi erew amsalp dna tnatanrepuS
                                g
si yassa DOS .Co4 ta nim 01 rof × 000,01 ta degufirtnec neht erew                                                                       g
                                                                                      .detcelloc saw tnatanrepus ehT .Co4 ta nim 01 rof ×
setanegomoh ehT .enilas cinotosi dloc eci ni dezinegomoh saw            000,01 ta degufirtnec neht erew setanegomoh ehT .)4.7 Hp( reffub
eussit laner dna niarB .)8991( euqinhcet .  la te
                                                nuS eht yb deyassa      lCH-sirT Mm 02 dloc eci ni dezinegomoh erew yendik dna niarB
saw ytivitca )1.1.51.1 :.C.E ;DOS( esatumsid edixorepus latoT                                      stcudorp noitadixorep dipil fo noitamitsE
                                   .mn 042 ta ecnabrosba mumixam                                           sserts evitadixo fo tnemssessA
                                                                                                                   p
                                                                                        .nicotozotperts sv 100.0 < c ;lortnoc sv 100.0 < a  p
                                                                                                     .star evif fo MES ± snaem era seulaV
      c
       3.0 ± 3.2            a
                             3.0 ± 3.1           3.0 ± 9.1              5.0 ± 4.2                              )nietorp gm/U( xP-HSG
      c
       3.1 ± 51.            a
                             0.1 ± 5.9           7.0 ± 41.              9.0 ± 41.                                   )nietorp gm/U( DOS
    c
     30.0 ± 2.00          a
                           10.0 ± 30.0          40.0 ± 2.00           40.0 ± 2.00                         )nietorp gm/U( 01 × esalataC
    c
     50.0 ± 6.00          a
                           40.0 ± 3.00          90.0 ± 6.00           60.0 ± 6.00                               )nietorp gm/lomn( HSG
      c
       1.1 ± 21.            a
                             2.1 ± 61.           6.1 ± 01.              4.1 ± 9.9        )nietorp gm/lomn( stcudorp noitadixorep dipiL
   nicotozotperts        nicotozotpertS          eniw deR                lortnoC
    + eniw deR
           nicotozotperts htiw ton ro detaert star ni eussit laner seitivitca esalatac dna )xP-HSG( esadixorep enoihtatulg ,)DOS( esatumsid
edixorepus dna ;tnetnoc )HSG( enoihtatulg decuder ,slevel stcudorp noitadixorep dipil ni segnahc no eniw der fo tceffE .3 elbaT
                                                                                                                   p
                                                                                        .nicotozotperts sv 100.0 < c ;lortnoc sv 100.0 < a  p
                                                                                                    .star evif fo MES ± snaem era seulaV
      c
       3.0 ± 3.2            a
                             2.0 ± 4.1           .04 ± 5.2              3.0 ± 0.3                              )nietorp gm/U( xP-HSG
      c
       6.0 ± 3.8            a
                             5.0 ± 3.6           8.0 ± 2.9              0.1 ± 5.9                                   )nietorp gm/U( DOS
    c
     20.0 ± 2.00          a
                           10.0 ± 1.00          30.0 ± 3.00           10.0 ± 3.00                         )nietorp gm/U( 01 × esalataC
    c
     40.0 ± 3.00          a
                           30.0 ± 2.00          40.0 ± 3.00           40.0 ± 3.00                               )nietorp gm/lomn( HSG
      c
       8.0 ± 1.7            a
                             6.1 ± 51.           1.1 ± 6.8              9.0 ± 7.8        )nietorp gm/lomn( stcudorp noitadixorep dipiL
   nicotozotperts        nicotozotpertS          eniw deR                lortnoC
    + eniw deR
           nicotozotperts htiw ton ro detaert star ni eussit niarb seitivitca esalatac dna )xP-HSG( esadixorep enoihtatulg ,)DOS( esatumsid
edixorepus dna ;tnetnoc )HSG( enoihtatulg decuder ,slevel stcudorp noitadixorep dipil ni segnahc no eniw der fo tceffE .2 elbaT
145                                                        setebaiD dna eniW deR
                                                                            deniatbo stluser ehT .yhtaporhpen citebaid dna setebaid ,sserts
      .eniw der eht gnidivorp rof )niapS ,abodroC ,allitnoM(                evitadixo larberec stneverp dna seitreporp evitcetorporuen
.A.S esuoheraw sayemO knaht eW stnemgdelwonkcA                              sah eniw der taht sa llew sa ,etats citebaid dna sserts evitadixo
                                                                            niarb secudni ZTS taht sisehtopyh eht troppus dnA .setebaid
                          .slevel nilusni amsalp gnicnahne elihw            fo esruoc dna noitulove eht ni dna ledom latnemirepxe
,aimecylgrepyh fo ytireves eht dna sserts evitadixo fo ytisnetni eht        siht ni sserts evitadixo eht fo elor tnatropmi eht etacidni
secuder eniw der ,suhT .star citebaid decudni-nicotozotperts                atad detcelloc eht ,esiwekiL .ZTS yb decudni segnahc eht
ni sserts evitadixo niarb ni )niapS ,abadroC( seliroM-allitnoM              detneverp eniw der fo noitartsinimda eht )v( ;airunimublaorcim
eht fo eniw der fo elor evitcetorporuen a rof ecnedive                      dna airunietorp detpmorp ZTS )vi( ;amsalp dna yendik ,niarb
oviv ni tsrif eht etutitsnoc stluser tneserp eht ,trohs nI                  eht ni semyzne evitadixoitna yek ni snoitcuder dna ,slevel
                      .)2002 noyrepaC-igaM ;4991 ,.    la te iniaS(         noitadixorep dipil ni esaercni na ,noitartnecnoc HSG ni pord
aimeloretselohcrepyh dna sserts evitadixo no sdnuopmoc                      a dereggirt ZTS )iii( ;xedni cinegorehta dna slevel loretselohc
cilonehpylop fo tceffe evitcetorp nwohs gnivah stroper                      latot amsalp desaercni ZTS )ii( ;slevel nilusni amsalp
suoiverp htiw tnemeerga ni era atad esehT .xedni cinegorehta                ni esaerced dna airusocylg ,aimecylgrepyh yb deziretcarahc
dna loretselohc latot deppord ZTS htiw noitanibmoc                          etats citebaid a decudni ZTS )i( :taht troper ew niereH
ni ,eniw der yduts ruo nI .xedni cinegorehta dna loretselohc                                                                         .decudni
latot amsalp tceffa yam eniw der taht etacidni ot mees stluser              -ZTS segnahc eht tsniaga eniw der fo stceffe evitcetorp
ruo ,yduts tneserp eht fo mia niam eht ton saw ti hguohtlA                  laitnetop eht denimaxe dna star ratsiW ni ZTS yb decudni
                                    .eniw der fo noitca evitcetorp          yhtaporhpen dna sserts evitadixo niarb eht detaulave ew ,suhT
eht tseggus dna yduts ruo ni dnuof esoht troppus sgnidnif                   .aimecylgrepyh dna sserts evitadixo cinorhc suonegodne
atad eseht fo llA .)2002 ,. la te  noridloC ;1002 ,.la te srednaS(          fo elpmaxe tnaveler a sedivorp setebaid decudni-ZTS
traeh dna niarb ,yendik ,revil sa hcus seussit tnereffid ni sutats
tnadixoitna desimorpmoc fo desrever nitecreuq taht dnuof                                                                             noissucsiD
puorg ’sniktaW ,eromrehtruF .)4002 ,arpohC dna uluyenajnA(
noitca evitadixoitna sti hguorht ylbaborp ,egamad laner
citebaid gnitaunetta ,tceffe evitcetorporhpen a gniwohs noitca                  .)3-1 selbaT( sretemarap derusaem eht ni segnahc decudni
evitadixoitna na yalp nac tnemtaert nitecreuq arpohC dna                    -ZTS eht fo lla etagitim did eniw der tub ,tceffe tnacifingis
                                    la te
uluyenajnA ot gnidroccA .)3002 ,. lasseV( sserts evitadixo fo               on dah enola eniw der ,stnemerusaem lacimehcoib lla nI
eerged eht desaerced ti sa llew sa ,stelsi citaercnap fo rebmun                                            .)1 elbaT( detavele erew nietorp
eht dna ,eliforp dipil ,seitivitca esanikoxeh dna esanikoculg               dna ,nimubla ,esoculg eniru hguohtla slevel nietorp mures dna
citapeh ,tset ecnarelot esoculg eht ytilamron ot desrever star ot           eninitaerc ,NUB eht no tceffe elttil dah ZTS .)1 elbaT( slevel
noitartsinimda ,stnalp dna seniw der ni tneserp ylediw si taht              nietorp dna ,nimubla ,esoculg eniru htiw gnola mures eht
dionovalf a ,nitecreuq taht dewohs seiduts rehto ,revoeroM                  ni nietorp latot dna ,eninitaerc ,NUB gnisu denimreted saw
.)4002 ,.la te allitnoM( nilusni saercnap dna amsalp fo slevel              yhtaporhpen fo noitanimreted ehT .)3-1 selbaT( amsalp ni dna
gnisaercni elihw ,nibolgomeah detalysocylg fo egatnecrep                    setanegomoh yendik dna niarb ni esalatac dna ,xP-HSG ,DOS
dna enimasotcurf amsalp ,aimecylg fo slevel desaerced                       ,HSG desaerced dna noitadixorep dipil desaercni htiw slamina
decudni eniw der htiw tnemtaert taht dnuof ew ,krow siht nI                 detaert-ZTS eht ni decudni osla saw sserts evitadixO
         la te
.)4002 ,. allitnoM( yduts suoiverp ruo htiw elbitapmoc era                                                                        .)1 elbaT(
stluser esehT .eniw der yb ylsuoiverp detneverp erew ZTS yb                 noitercxe esoculg dna ,esoculg amsalp fo slevel hgih dna
dereggirt anemonehp lacimehcoib eht ,troper tnerruc eht nI                  ,noitcudorp nilusni fo slevel wol htiw slamina citebaid ecudorp
                 .slevel nilusni amsalp ni esaerced tnacifingis a           noitcejni ZTS eht taht detacidni sretemarap lacimehcoib ehT
devresbo ew ,atad eseht ot noitidda nI .slevel nilusni amsalp ni
deppord sa llew sa ,noitercxe esoculg yraniru dna aimecylg fo                                                                             stluseR
slevel hgih sa hcus ,setebaid fo lacipyt sngis lacimehcoib htiw
sedicnioc eussit laner dna niarb ni sserts evitadixo fo eerged                                         .spuorg owt neewteb secnereffid erapmoc
hgih ehT .snoitcnuf laner tceffa nac taht srotaidem evitcaosav                                  t
                                                                            ot desu saw tset- s’tnedutS .M.E.S ± naem sa desserpxe era
fo yteirav a fo noitamrof eht etomorp dna htaed llec ot                                         p
                                                                            stluser llA .50.0 < ta tes saw ecnacifingis lacitsitats fo level ehT
gnidael egamad evitadixo dna noitadixorep dipil ecudni htob                 .snosirapmoc elpitlum rof noitcerroc inorrefnoB yb dewollof demrofrep
nac sserts evitadixO .sserts evitadixo niarb dna yhtaporhpen                saw )AVONA yaw-eno( ecnairav fo sisylana yaw-eno a ,atad ni
,etats citebaid gnoma noitalerroc tnacifingis a dnuof osla eW               snoitairav etaulave oT .seulav ecnairav fo noitubirtsid eht ni ytilamron
.sserts evitadixo na decudni nixot siht taht dnuof ohw ,)0002               morf erutraped tnacifingis a wohs ton did tset kliW-oripahS ehT
 la te
,.      rehcsuaR ;6991 ,. la te  onailgiuG ;5991 ,.  la te rakkaK(          .egakcap erawtfos lacitsitats ®SSPS eht fo snaem yb dehsilpmocca
srehcraeser rehto dna ,)1991( senyaB ,)3991 ;0991( . tnuHla te              saw atad eht fo sisylana lacitsitatS             sisylana   lacitsitatS
,)4991( .la te  ziuR ,)4002 ;8991 ,.  la te allitnoM ;3991 ,.    la te
zoñuM(.  la te allitnoM morf stroper eht htiw tnemeerga ni era                                  .)4002 ,.la te   zenítraM-onarreS( ]c-LDH/CT[ sa
                                                               .la te allitnoM ordeP                                                            245
,59 .loidraC .J .tnI ?detaidem-dipil esaesid tareH yranoroc no            fo msinahcem desoporp ni secnereffid latnemadnuf emoS
teid fo stceffe eht era tnetxe tahw oT )4002( .A .M ,zeláznoG             :noitadixo tcudda esoculg-nietorp ot eud era sutillem setebaid
-zenítraM dna .E ,enraJ-zednáneF ,.C ,uafurB-aloragurB                    fo ledom noitacylg latnemirepxe eht ni snoitaretla evitadixO
,.M ,aíramatnaS-odarP ,.E ,adasoL-zenítraM ,.M ,zenítraM-onarreS          )3991( .J .M ,nosnihctiM dna .A .M ,smottoB ,.V .J ,tnuH
                                                         .611-901 ,38         .9084-8084 ,98 .coS .mehC .mA .J .nicotozotperts fo erutcurts
.locamrahponhtE .J .setebaid latnemirepxe ni sserts evitadixo             ehT )7691( .D .A ,sileduogrA dna .D .A ,eknhaJ ,.R .R ,rreH
gnicuder ni elor rieht dna slonehpyloop aet neerg fo ytivitca                   .12-81 ,84 .tnI yendiK .yhtaporhpen citebaid fo tnempoleved
citebaic-itnA )2002( .R ,nattuK dna .K ,htimS ,.C .M ,ubaS                eht ni sserts evitadixo fo eloR )5991( .H .K ,miK dna .H ,aH
              .941-341 ,51 .locixoT .loM .mehcoiB .J .star citebaid                                                                    .762-752
decudni-nicotozotperts ni esnefed tnadixoitna no nitecreuq fo             ,91 .eraC setebaiD .snoitacilpmoc ralucsav citebaid dna sserts
tceffE )1002( .B .J ,sniktaW dna .M .F ,rehcsuaR ,.A .R ,srednaS          evitadixO )6991( .G ,ossiloaP dna .A ,olleireC ,.D ,onailguiG
                                                              .643-333          .945-245 ,32 .icsorueN sdnerT .sutillem setebaid ni yticitsalp
,02 .loidraC .J .naC .noitcnufsyd ralucsavoidrac ni loretselohc           citpanys dna noitingoC )0002( .J .G ,slesseiB dna .H .W ,nepsiG
fo eloR )4002( .S .N ,allahD dna .S .A ,ajenrA ,.K .H ,iniaS                                  .852-452 ,41 .lorhpeN .coS .mA .J .yhtaporhpen
                                                  .501-99 ,95 .tsevnI     citebaid ni stcudorp dne noitacylg decnavda fo eloR )3002(
.baL .nilC .J .dnacS .sutillem setebaid I-epyt htiw tneitap               .C .M ,samohT dna .D .M ,dleifdlO ,.E .M ,repooC ,.M .J ,sebroF
ni seitivitca emyzne tnadixoitna dna noitadixorep dipiL )4991(                                   .121-411 ,501 .lomyznE sdohteM .esadixorep
.J .M ,adragaL dna .R ,erraF ,.R ,arebraB ,.A ,airgelA ,.C ,ziuR          enoihtatulg fo syassA )4891( .A .W ,relznuG dna .L ,éholF
                                          .491-981 ,41 .locixoT .loM                                  .946-546 ,8 .siD yretrA .noroC .xodarap
.mehcoiB .J .star citebaid dna lamron ni esnefed tnadixoitna no           hcnerF eht dna esaesid traeh cimehcsi ,lohoclA )7991( .J ,tnatsnoC
G98347-UNP dna F760401-UNP sdnuopmoc tnadixoitna wen                                                                     .202-791 ,61 .locixoT
fo stceffE )0002( .B .J ,sniktaW ,.A .R ,srednaS ,.M .F ,rehcsuaR         .loM .mehcoiB .J .star citebaid dna lamron ni sserts evitadixo
                                              .421-311 ,5 .deM .loiB      no tnemtaert 01Q emyzneoC dna nitecreuq denibmoc fo
.cidaR eerF .setebaid dna slacidar eerF )8891( .W .L ,yeldrebO            stceffE )2002( .B .J ,sniktaW dna .A .R ,srednaS ,.D .A ,noridloC
               .711-411 ,5 .relcsoiretrA .tsevnI .nilC .E animativ al        .452 -842 ,27 .mehcoiB .lanA .gnidnib eyd-nietorp fo elpicnirp
ed sotcefE .anicotozotpertse rop sacitébaid satar ne socitámsalp          gnizilitu nietorp fo seititnauq margorcim fo noitatitnauq
sodixórepopil y animasotcurf ,esoculg al ed ovitulove                     rof dohtem evitisnes dna dipar A )6791( .M .M ,drofdarB
osruC )3991( .P ,allitnoM dna .T ,sarroP ,.I ,zenúT ,.C .M ,zoñuM                                 .41-1 ,44 .locamrahP .J .ruE .noitcnuf niarb
                                                           .5341-7041     rof snoitacilpmi :setebaid dna gniegA )2002( .H .W ,nepsiG
,11 .sgurD .gitsevnI .nipO trepxE .sredrosid evitarenegedoruen            dna .L .R ,syelB ,.A ,lamaK ,.P .L ,edieH red nav ,.J .G ,slesseiB
rof tnemtaert sa stnadixoitnA )2002( .C ,lheB dna .B ,nnamsoM                                             .056-346 ,73 .aigolotebaiD .sutillem
                                                     .001-49 ,52 .seR     setebaid ni noitcnuf larbereC )4991( .H .W ,nepsiG dna
laeniP .J .ninotalem fo stceffe evitcetorp :nicotozotperts yb             .W .D ,snelekrE ,.B ,reobnevarB ,.C .A ,elleppaK ,.J .G ,slesseiB
decudni star citebaid ni sserts evitadixO )8991( .E ,arerbaC dna                  .4-1 ,094 .locamrahP .J .ruE .ecaferp a :esaesid dna htlaeh
.E .M ,arivledlaV ,.C .M ,zoñuM ,.I ,zenúT ,.J ,sagraV ,.P ,allitnoM      ni yticitsalp citpanys dna noitaludom :niarb eht dna nilusni
          .396-886 ,51 .mechoiB .rtuN .J .tar eht ni nicotozotperts       ,esoculG )4002( .H .W ,nepsiG dna .G ,reobnevarB ,.J .G ,slesseiB
yb decudni sserts evitadixo no eniw der noitalleppa seliroM                                                                  .9-1 ,83 .setebaiD
-allitnoM fo tceffe evitcetorP )4002( .I ,zenúT dna .I ,ecnalajuB         .mgidarap dlo na no evitcepsrep wen A .snoitacilpmoc citebaid
,.R .J ,adeñatsaC-zoñuM ,.C .M ,zoñuM ,.M ,socraB ,.P ,allitnoM           ni sserts evitadixo fo eloR )9991( .R ,eprohT dna .W .J ,senyaB
                                              .075-755 ,14 .setebaiD                        .214-504 ,04 .setebaiD .setebaid ni snoitacilpmoc
.SNC eht no setebaid fo tcapmi ehT )2991( .L .A ,llaCcM                   fo tnempoleved ni sserts evitadixo fo eloR )1991( .W .J ,senyaB
            .103-692 ,31 .mehcoiB .rtuN .J .revil tar ni noisserpxe                           .418-908 ,52 .eraC setebaiD .nemow naciremA
emyzne tnadixoitna ecnahne ton seod tub noitdixorep secudni               -nacirfA ni setebaid fo ksir eht ecuder ot snrettap yrataid
E nimativ ni tneicifed dna loretselohc ni hgih teid A )2002(              gnigats fo noitaulave dellortnoc A )2002( .H .J ,smailliW
.B ,spmocseD dna .L .C ,regeL ,.P ,nocnaseB ,.M .J ,tenauoR               dna .W .C ,eehR ,.C ,notsuoH ,.D ,uhsoJ-eriaH ,.W ,rednalsuA
,.P .J ,lotsirC ,.E ,aidaB ,.J ,sesaC ,.F .M ,noyrepaC-iggaM                                                 .842-442 ,13 .loisyhP .locamrahP
                                  .911-311 ,151 .mehcoiB lleC .loM        .pxE .nilC .star ni yhtaporhpen citebaid setaunetta ,dionovalfoib
.star citebaid ni semyzne tnadixoitna fo ytivitca dna noitdixorep         tnadixo-itna na ,nitecreuQ )4002( .K ,arpohC dna .M ,uluyenajnA
dipiL .K dasarP )5991( .V .S ,ahtnaM dna .J ,arlaK ,.R ,rakkaK                                                                         .056-746
                                             .5761-5661 ,362 .mehC        ,132 .lomlahthpO .pxE .nilC .hcrA sefearG .yhtapniter citebaid
.loiB .J .edixorep negordyh yb detavitcani stegrat ralullecartni          evitarefilorp morf gnireffus stneitap fo suoertiv eht ni ytivitca
rojam era noitalyrohpsohp PDA fo syawhtap lairdnohcotim                   esadixorepoleym dna slevel edixorep dipil desaercnI )3991(
dna citylocylg eht :yrujni llec detaidem-tnadixo fo msinahceM             .M ,sabztipS dna .J ,ztuL ,.T ,rekoB ,.W ,lhopierB ,.J .A ,nitsugA
)8891( .rJ .H .W ,yeslaH dna .B .D ,awhsniH ,.A .P ,polsyH                  .005-974 ,43 .lomyznE sdohteM .ortiv ni esalataC )4891( .H ,ibeA
                                                                 .4241                                                .6941-9841 ,54 setebaiD
-0241 ,93 .setebaiD .esoculg yb noitacifidom LDL ni slacidar              .slamina citebaid dna lamron fo snahregnaL fo stelsi eht
eerf dna sedixorep fo tnemevlovni elbissop dna noitalisocylg              ni nilusni fo noitacylG )6991( .R .P ttalF dna .R .C ,ttenraB ,.H
evitadixotuA )0991( .P .S ,ffloW dna .C ,htimS ,.V .J ,tnuH               .N ,nahganelCcM ,.H ,ffilctaR ,.P .F ,etraH’O ,.H .Y ,bahaW ledbA
                                                              .262-952
,192 .J .mehcoiB .noitcudorp tnadixo dna noitadixo esoculg                                                                      secnerefeR
345                                                          setebaiD dna eniW deR
                                 .253-933 ,01 .deM .loiB .cidaR                                                              .086-376 ,52
eerF .gniega dna sutillem setebaid ni sserts evitadixo dna              .seR .nilC .pxE sgurD ?tnatcetorporuen a eb eniw thgim :sllec
noitacylg nietorP )1991( .V .J ,tnuH dna .Y .J ,gnaiJ ,.P .S ,floW      lanoruen dna sesanik pam ,lortarevseR )9991( .A ,illetreB dna
                     .463-753 ,531 .C .loisyhP .mehcoiB .pmoC           .G ,ittellavaC ,.S ,itaiblaG ,.G ,inilociN ,.M ,osoliM ,.G ,iciderT
.star citebaid decudni-nicotozotperts ni nitecreuq fo stceffe            .645-635 ,05 .seR .loisyhP .saercnap tar eht fo sllec-b ni noitca
citebaiditnA )3002( .M ,iesaV dna .M ,itammeH ,.M ,lasseV               nicotozotperts dna naxolla fo msinahcem ehT )1002( .T ,iksledukzS
                                   .621-321 ,182 .tteL .icsorueN                                                                      .005
.star ni lortarever-snart ,tnega tnadixoitna eniw der eht               -974 ,43 .mehC .nilC .esatumsid edixorepus fo yassa lacinilc
fo noitartsinimda cinorhc yb egamad niarb cixototicxe oviv ni           rof dohtem elpmis A )8991( .Y ,iL dna .W .L ,yelrebO ,.Y ,nuS
fo noitcetorporuen laitraP )0002( .A ,elibatsetnoC dna .M ,iligriV                                                                  .83-53
                                                           .la te allitnoM ordeP                                                       445

				
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Description: High-quality red wine is rich in iron, is very good for women, can play a role in the blood, so that his face became red. Meanwhile, the female body during pregnancy, there will be a significant increase in fat content, and post-drink some wine, which antioxidants can prevent the oxidation of fat accumulation, the recovery of the body is helpful. "Some may ask, after all, wine is wine, are in lactating women drink? Wine alcohol content is not high, as long as the person with an allergy not alcohol a day to drink a small cup (about 50 ml) is not the problem.