Dow nstate M edical Center – Office of Scientific Affairs
FACULTY MENTORS AND THEIR RESEARCH INTERESTS
** Unless otherwise noted, phone numbers are at the (718) 270- exchange **
BASIC SCIENCE DEPARTM ENTS
Department of Anatomy & Cell Biology
W illiam J. Brunken, PhD (221-5328) CNS developm ent and specifically on the role of extracellular m atrix in
william .brunken@ downstate.edu m orphogenesis of neurons and neural system s. The retina is the
m ajor m odel system in the laboratory, with an em phasis on retinal
structure and function, including photoreceptor synapse form ation.
Recently, we have been pursuing studies on cortical and cerebellar
m orphogenesis as well. Our work is focused on lam inin, netrins and
their receptors. Using a com bination of genetic approaches and in
vitro m odel system s, we have shown that specific lam inins and netrins
are critical for: 1) norm al layering and patterning; 2) norm al
vascularization and finally 3) proper synaptic developm ent. The
cerebellum and cortex are secondary m odels we have shown that
lam inins and netrins, are critical for: 1) in the regulation of
neurogenesis and 2) cyto-architectonic organization of the cortex and
cerebellum . An im m ediate goal of ours is to identify the cell binding
and cytom atrix m olecules that com plex with identified elem ents of the
extracellular m atrix. Our short-term goal is to identify the role of these
m olecules in hum an disease. Finally, our long-term goal is to
incorporate biologically active m olecules into polym ers that can be
used in neural repair strategies.
Stephen Carleton, PhD (x3749) Molecular analysis of gene expression in the developing chick heart,
email@example.com specifically the genetics or "switch on" of two cardiac-special genes
and two skeletal m uscle-specific genes during critical stages of
developm ent. Collaborations on projects involved in genetic analysis
(DNA fingerprinting) of Mycobacterium tuberculosis.
W illiam J Chirico, PhD (x1308) Biogenesis of angiogenic factors and their roles in cardiovascular
william .chirico@ downstate.edu disease and cancer. Mechanism of chaperone-dependent protein
folding and translocation into organelles.
Eva B Cram er, PhD (x1011) Developm ent of i) a biotech incubator & park adjacent to the cam pus,
eva.cram er@ downstate.edu and ii) a biotech expansion/m anufacturing site at the Brooklyn Arm y
Sabina Hrabetova, PhD (221-5392) Biophysical properties of the brain extracellular space im portant for
sabina.hrabetova@ downstate.edu neurotransm ission, neurotrophic effects, drug delivery, general electric
activity, and basic cellular hom eostasis. Focus: role of glia and
extracellular m atrix. Interdisciplinary approach: im aging,
electrophysiology, com puter m odeling.
Mahm ood Hussain, PhD (x4790) Molecular m echanism s of intestinal lipoprotein assem bly.
m ahm ood.hussain@ downstate.edu
Xian-Cheng Jiang, PhD (x6701) Create and use m ouse m odels (transgenic, gene knock-out) for the
firstname.lastname@example.org studies of sphingom yelin (the second abundant phospholipid in the
circulation system ) m etabolism and atherosclerosis. Use of transgenic
approach to perform functional studies of two plasm a lipid transfer
proteins, phospholipid transfer protein (PLTP) and cholesteryl ester
transfer protein (CETP).
Elizabeth Kornecki, PhD (x2377) Investigation of m olecular m echanism s underlying cellular
[Anna Babinska, PhD (x4049)] hom eostasis by studying the role of
elizabeth.kornecki@ downstate.edu phosphorylation/dephosphorylation system s in platelet function;
anna.babinska@ downstate.edu m echanism s of platelet activation by stim ulatory antibodies directed
against novel platelet m em brane glycoproteins; and collaborative
clinical studies investigating the role of platelet-activating factor (PAF)
in pediatric NEC, PAF in learning and m em ory, and abnorm al platelet
activation m echanism s in kidney dysfunction.
John L Kubie, PhD (x2632) Study the role of the hippocam pus in navigation, learning and
jkubie@ downstate.edu m em ory, analyzing single-cell recordings from awake behaving rats.
Study the relationships between the anim als’ position in space, the
anim als’ experience and the firing of target cells. Other technical
approaches involve analysis of navigation, the study of evoked
potentials and the study of the effects of drugs or horm ones on
neuronal firing properties.
Martin G Levine, PhD (x7427) Effectiveness and learning enhancem ent of alternative approaches to
m email@example.com instruction are being investigated in the anatom ical sciences. This
includes instructional m aterials as well as practices.
John A Lewis, PhD (x2215) Study of m echanism s by which interferons regulate expression of
john.lewis@ downstate.edu genes and their effects on sensitivity to virus infection and
m itochondrial function.
George K Ojakian, PhD (x2216) Molecular and cellular m echanism s regulating kidney epithelial tubule
firstname.lastname@example.org m orphogenesis. The present focus is on the role of the m TOR
signaling pathway in regulation of cell m otility, growth and proliferation.
Frank R Scalia, PhD (x1018) The im aging surface of the retina is m apped point for point onto the
frank.scalia@ downstate.edu visual centers of the brain, providing the brain with a coherent view of
the visual world. The form ation of these visuotopic m aps, which are
essential for norm al vision, is being studied during developm ent and in
m odels of optic nerve regeneration.
MAQ Siddiqui, PhD (x1014) Molecular m echanism s in cardiac developm ent. Signal transduction
[Eduardo Mascareno, PhD] pathways and transcription adaptation in m yocardial hypertrophy and
[Michael W agner, PhD (x3984)] ischem ia. The role of obesity and the inflam m atory response, as m ajor
m aq.siddiqui@ downstate.edu contributors in the developm ent of chronic cardiovascular diseases,
eduardo.m email@example.com such as cardiac hypertrophy, m yocardial ischem ia, and heart failure.
m ichael.wagner@ downstate.edu
Gladys Teitelm an, PhD (x2950) Type I diabetes results from the destruction of insulin producing cells
gladys.teitelm firstname.lastname@example.org (B cells) of the pancreas. The m ain focus is to establish an anim al
m odel of type I diabetes to identify B precursor cells and to study their
differentiation into insulin cells of adults.
Department of Biochem istry
Richard Feinm an, PhD (x2252) Mechanism of action of proteolytic enzym es and their inhibitors.
rfeinm email@example.com Com puter m odels of operant conditioning.
Miriam H Feuerm an, PhD (x1258) Molecular m echanism that separates controlled norm al growth from
m iriam .feuerm firstname.lastname@example.org carcinogenesis. Study regulation of gene expression in liver
regeneration and tum origenesis.
Gregory Gick, PhD (x1265) Investigation of the m olecular m echanism s underlying regulation of
greg.gick@ downstate.edu m am m alian Na,K-ATPase subunit gene expression in response to
horm ones and ionic stim uli.
Alan Gintzler, PhD (x2129) Biochem ical basis of narcotic addiction. Sex steroid m odulation of
alan.gintzler@ downstate.edu intrinsic pain attenuating system s. Signal transduction and narcotic
Mary Makowske, PhD (x3991) Protein kinase C is a fam ily of hom ologous isoenzym es involved in
m ary.m akowske@ downstate.edu m any signal transduction pathways. Study the structure of these
enzym es and how they recognize their target substrates.
Richard Rubenstein, PhD (x2019) The laboratory is studying the m olecular and biochem ical basis of
richard.rubenstein@ downstate.edu neurodegenerative diseases which includes an interest in Alzheim er's
disease and a m ajor focus on prion diseases. These diseases share
a com m on feature of abnorm al protein aggregation. Molecular,
biochem ical, im m unological and cell biological approaches in both cell
culture and in vivo m odels of infection are being em ployed to address
the disease-specific issues of neuropathogenesis, neuroprotection
Julie Rushbrook, PhD (x2647) Structural characterization of fast m yosin heavy chain isoform s
julie.rushbrook@ downstate.edu associated with developm ent and m uscle fiber differentiation.
Characterization of the four nonidentical subunits of m am m alian
m itochondrial NAD+ isocitrate dehydrogenase and 3-D analysis.
Characterization of various hum an serum proteins associated with
Alfred Stracher, PhD (x1256) The m olecular basis of neurom uscular degeneration and the role of
alfred.stracher@ downstate.edu thiol proteases in this process using protease inhibitors as therapeutic
agents. Cytoskeleton structure with particular em phasis on the role of
phosphorylation in regulating the interaction of actin with platelet
Department of M icrobiology & Immunology
Christopher U Hellen, PhD (x1034) The m echanism of cap-dependent initiation of translation in
email@example.com eukaryotes. Analysis of RNA-protein interactions that m ediate initiation
of translation by internal ribosom al entry on eukaryotic viral m RNAs,
using hepatitis C virus and encephalom yocarditis virus m RNAs as
Maureen V McLeod, PhD (x1331) Signal transduction m echanism s that regulate exit from the m itotic cell
m aureen.m firstname.lastname@example.org cycle. Control of protein kinase activity in the stress response.
Donald R Mills, PhD (x3815) Studying the conform ation of m essenger RNA as it relates to the
donald.m ills@ downstate.edu regulation of protein synthesis. Also exam ining RNA protein
Cam ilo A Parada, PhD (x1143) Mechanism (s) by which the HIV-encoded Tat protein, in conjunction
cam email@example.com with cellular factors, enhances transcription elongation from the HIV-1
prom oter. Exploration of the contribution of Tat and cellular factors to
HIV-1 transcription re-initiation, transcription through nucleosom es,
and m RNA processing.
Tatyana Pestova, PhD (x1781) Mechanism of initiation of eukaryotic protein synthesis.
Christopher A J Rom an, PhD (x1310) Lym phocyte developm ent and renal cell carcinom a. W e study
christopher.rom firstname.lastname@example.org transcription factors, cytokine pathways, and antigen receptor
com plexes that are im portant for lym phocyte developm ent, the
im m une response, autoim m une disease, leukem ia/lym phom a, and
renal cancer, using transgenic/knock-out m ouse m odels, prim ary
m am m alian cell culture system s, and som atic gene
inactivation/retroviral transduction approaches.
Haseeb A Siddiqi, PhD (x1610) Host-parasite interactions, and m echanism s of pathogenesis and
haseeb@ downstate.edu im m unity in schistosom iasis; reproductive biology of schistosom es
and m echanism s of chem oattraction in schistosom e m ales and
fem ales; im m une regulation in schistosom iasis and in sepsis;
cytokines in infection and in local tissue injury.
Fredric C Volkert, PhD (x3923) Developm ent and evaluation of active learning strategies in m edical
fredric.volkert@ downstate.edu education.
Department of Pathology
Juan Marcos Alarcon, PhD (718-221- Molecular and cellular m echanism s underlying the interaction between
5325) distinct form s of synaptic plasticity in the CA1 area of the rodent
juanm email@example.com hippocam pus: consequences at synaptic, dendritic and neuron-wide
level and im pact on the hippocam pal network.
Virginia M Anderson, MD (x1292) Morphologic alterations in pediatric and perinatal disease including the
firstname.lastname@example.org placenta in HIV disease, congenital m alform ations especially
congenital heart disease.
Constantine Axiotis, MD (245-5371) The expression of the m ultidrug resistance gene
constantine.axiotis@ downstate.edu (MDR-P-glycoprotein) in hum an tum ors; and the m olecular pathology
of breast cancer.
Randall L Barbour, PhD (x1661) Developm ent of real-tim e functional im aging technologies for early
randall.barbour@ downstate.edu disease detection, m onitoring response to therapy and evaluation of
norm al tissue functioning.
Patrick C Chen, MD (x1667) Assess acetylcholinesterase stain and other m ethods in the diagnosis
email@example.com of Hirschsprung's disease. Using im m unohistochem ical reagents for
pathological diagnosis, assessing the usefulness of the reagents.
Helen G Durkin, PhD (x1295) Studies of IgE responses of long term survivors with HIV-1 disease.
helen.durkin@ downstate.edu Role of gut associated lym phoid tissue (GALT) in generation and
suppression of IgE responses in hum ans (allergic, HIV+) and rodents.
Attem pting to determ ine how IgE responses can be elim inated,
without interfering with hum oral antibody responses of other isotopes
(IgM, IgG, IgA) or cell m ediated im m une responses. Studies focus on
role of bacterial cell wall com ponents, cytokines, especially IL-6, and
neuropeptides, especially substance P, in isotype specific suppression
of IgE responses.
Elizabeth S Gloster, MD (x1681) Review of the Downstate and Kings County experience with red cell
elizabeth.gloster@ downstate.edu alloim m unization in sickle cell patients, clinical aspects of transfusion
reactions and the off-label use of recom binant factor VIIa.
Susan RS Gottesm an, MD, PhD (x1661) Studying the changes in the im m une system during norm al aging in
susan.gottesm firstname.lastname@example.org m ice. Study the characteristics of lym phoid m alignancies using patient
m aterial. W ill be setting up a tum or bank.
Alejandro Ivan Hernandez, PhD Understanding the m olecular m echanism s regulating long-term
ivan.hernandez@ downstate.edu synaptic plasticity and the alterations of those m echanism s associated
with neurodegenerative disorders and drug addiction.
Joan Howanitz, MD (x4520) Clinical chem istry including hem oglobinopathies; critical results for
joan.howanitz@ downstate.edu sodium and cardiac m arker utilization.
Peter Howanitz, MD (x4520) Quality of care; chem ical pathology.
Jenny Libien, MD (x6304) Retinoids (vitam in A and its analogues) and retinoid transport proteins
email@example.com (RBP, TTR) in the central nervous system : transport, m etabolism , and
function. Retinoids are involved in m em ory, adult neurogenesis, cell
differentiation, and m any other physiologic processes. Retinoids have
also been im plicated in several diseases such as idiopathic
intracranial hypertension, depression, and neurodegenerative
diseases such as Alzheim er's disease and Am yotrophic Lateral
Josef Michl, MD (x1643) Study of the cells involved in host defense m echanism against
josef.m firstname.lastname@example.org infectious agents and tum ors, and of carcinogenesis in the exocrine
pancreas in anim als and m an: Establishm ent of novel in vitro and in
vivo disease m odels for the identification of unique disease-specific
m olecules for the developm ent of early diagnostic approaches and
effective therapeutic tools for this disease.
Suzanne Mirra, MD (x1291) Neuropathology of Alzheim er's disease and other neurodegenerative
suzanne.m irra@ downstate.edu disorders.
Maja Nowakowski, PhD (x2206) System ic and local pulm onary im m unity in lung diseases, including
m aja.nowakowski@ downstate.edu HIV-1 disease, tuberculosis and chronic inflam m atory disease. The
role of m acrophage-derived nitric oxide in lung diseases, including
asthm a, HIV-1 disease, tuberculosis, and chronic inflam m atory
disease. Effects of virus infection on macrophage physiology and
im m une functions.
Martin J Salwen, MD (x1689) Define outer lim its of laboratory test analyses. Develop program s for
m artin.salwen@ downstate.edu interpretive analysis of clinical laboratory data using rule-based logic
and pattern analysis. Program s have incorporated m odules for
instruction in testing strategies for differential evaluation of patients.
Program s have been developed for erythrocytosis. Strategies for rapid
bacterial identification in sepsis.
Department of Physiology and Pharmacology
Bella T Altura, PhD (x2205) Study drugs and ion (particularly m agnesium ) effects on the
burton.altura@ downstate.edu cardiovascular system , in intact anim als, in vitro heart and blood
vessels and single cells via culture. Designs and participates in hum an
studies centering on im portance of ionized m agnesium in disease
Burton M Altura, PhD (x2194) Focus on m agnesium in cardiovascular biology, both in anim als and
burton.altura@ downstate.edu hum an subjects. Involved in new diagnostic and prognostic test
developm ent, and new m edical devices. Studies biochem ical and
m olecular physiological processes in atherogenesis and stroke.
Prim ary cultured vascular sm ooth m uscle, endothelial and glial cells
Vahe E Am assian, MD (x3900) Magnetic or electrical transcranial stim ulation of hum an (or anim al
vahe.am email@example.com m odels) is used to analyze m otor and perceptual functions.
Lateralization is sought including differential effects on the im m une
system . Anim al m odels of hum an disorders (e.g., spinal cord traum a)
are used to elucidate the basic explanations of the im paired function.
Peter J Bergold, PhD (x3927) Interested in the role of gene expression in the pathophysiology of
peter.bergold@ downstate.edu neuronal disorders, particularly stroke and epilepsy.
John Chapin, PhD (x1339) Develop and utilize technologies for neurophysiologically recording
john.chapin@ downstate.edu from large populations of neurons in sensory and m otor areas of the
brain. Com puter techniques for online extraction of coded inform ation
in the brain are used to control external devices such as robot arm s.
Diana L Dow-Edwards, PhD Use neuro-im aging and neuropharm acologic techniques to study the
diana.dow-edwards@ downstate.edu effect of drug exposure during brain developm ent. The overall
(x3987) hypothesis is that the actions of drugs, typically cocaine or sim ilar
drugs, alters the functional m aturation of the brain.
David J Erlij, MD, PhD (x2243) Horm onal regulation of m em brane transport.
André A Fenton, PhD (X1556) W e investigate the storage m echanism s of inform ation as well as how
firstname.lastname@example.org m ultiple item s of inform ation are coordinated in brain activity by
investigating the neural discharge of m any neurons while anim als
perform tasks using m ultiple, concordant spatial fram es. These
studies aim to elucidate physiological m echanism s of cognition and
cognitive dysfunction related to schizophrenia, depression, and
Steven E Fox, PhD (x2177) Study the EEG theta rhythm in rats to understand how it influences
steven.fox@ downstate.edu inform ation processing by the hippocam pus. Theta rhythm occurs
during m ovem ent and is paced by cholinergic neurons that project
from the m edial septal nuclei to the hippocam pus. The degeneration
of these basal forebrain cholinergic neurons is probably the cause of
the m em ory deficit of Alzheim er's patients.
Ellen Hsu, PhD (x1154) Im m unoglobulin gene expression and regulation.
Douglas Ling, PhD (x4631) The potentiation of GABAergic inhibition by nootropic
email@example.com (cognition-enhancing) drugs induced by changes to inhibitory cell
function. Injury-induced changes in synaptic function that lead to
epileptiform activity, using a m odel of acute neuro-traum a.
W illiam Lytton, MD (x1339) Modeling electrophysiological processes pertinent to epilepsy and
firstname.lastname@example.org m odeling abstract neural networks to understand recovery from stroke
and the basis of cognitive processes. Developm ent and application of
new conceptual and technical tools to integrate the top-down
techniques of artificial neural networks with the bottom -up techniques
of detailed neural m odeling.
Hillary Michelson, PhD (x3182) Studying the connectivity of the inhibitory circuit in the hippocam pus
hillary.m email@example.com and the m aturation of GABA m ediated inhibition.
Robert Muller, PhD (x1151) Physiology of learning and m em ory; m easurem ents of place cells in
bobm ul@ fasthp.hippo.downstate.edu rats and genetically-altered m ice; pharm acological effects on place
Nicholas Penington, PhD (x3399) Study the regulation of nerve cells in the brain that release the
firstname.lastname@example.org neurotransm itter (5-HT) and focus on central serotonergic (5-HT)
neurotransm ission and neuropharm acology. Studies of the m olecular
level on the signal transduction pathways in these nerve cells and
investigations of how drugs interact with a single receptor system ,
capable of m odulating two different ion channels sim ultaneously.
Katherine L Perkins, PhD (x2772) Synaptic transm ission in the hippocam pus -interneuron networks,
katherine.perkins@ downstate.edu epileptiform activity, depolarizing GABA response.
Alan P Rudell, PhD (x1150) Electrical brain responses to recognizable im ages (words, pictures,
alan.rudell@ downstate.edu faces) are recorded and related to acquired perceptual skills (e.g.,
Todd Sacktor, MD (x3933) The role of protein kinase C isozym es in long-term synaptic plasticity
todd.sacktor@ downstate.edu (LTP & LTD), and their relationship to m em ory.
Anthony Sica, PhD (x1232) Chronic m onitoring of physiological variables (EEG, EKG, sleep) in a
anthony.sica@ downstate.edu developing anim al m odel (swine). Recordings of the sym pathetic and
respiratory rhythm generators (output) during postnatal developm ent.
Effects of autonom ic denervation of the heart on cardiovascular
reflexes during developm ent. Exam ination of postnatal developm ent
of autonom ic regulation using different techniques including
im m unocytochem ical.
Sheryl S Sm ith, PhD (x1339) Modulation of hippocam pal and olivo-cerebellar circuits by neuroactive
sheryl.sm ith@ downstate.edu steroids. Currently investigating steroid-induced changes in synaptic
physiology induced by alterations in GABAA receptor subunit
com position. Behavioral correlates, such as anxiety and seizure
susceptibility, are also under investigation. Possible clinical relevance
for PMS and catam enial epilepsy.
Arm in Stelzer, MD (x3873) Intracellular regulation of ligand-gated receptors. Activity-dependent
arm in.stelzer@ downstate.edu m odification of the inhibitory circuit.
Mark Stewart, MD, PhD (x1167) W e study the causes and consequences of seizure activity using in
m ark.stewart@ downstate.edu vivo and in vitro anim al m odels. W ith brain slice studies, we explore
the cellular and circuit properties of hippocam pal and
parahippocam pal cortical neurons. In whole anim al studies we explore
the autonom ic nervous and im m une system consequences of
seizures. ANS and im m une system consequences are also studied in
patients from our Epilepsy Monitoring Unit.
Henri Tiedge, PhD (x1370) Sorting and intracellular targeting of neuronal RNA.. Local protein
email@example.com synthesis in neurons. Regulation of gene expression in neurons by
Roger Traub, PhD (x) Cellular m echanism s of neuronal network oscillations and seizures.
Mario Vassalle, MD (x1158) The electrical function of the heart is studied using different
m ario.vassalle@ downstate.edu techniques, from transm em brane recording to voltage clam ping.
Norm al and abnorm al autom aticity is studied in different cardiac
tissues. Ionic m echanism s and their control are studied in relation to
im pulse form ation under norm al and abnorm al conditions.
Keith W illiam s, PhD (x4610) Structure, function, and regulation of glutam ate receptors.
keith.william s@ downstate.edu
Robert KS W ong, PhD (x1339) Transm itter m odulation of hippocam pal neuronal network
bob.wong@ downstate.edu m echanism s of epileptogenesis.
CLINICAL DEPARTM ENTS
Department of Anesthesiology
Alexandru Apostol, MD (x1910 or 2530) The effect of m agnesium sulfate on neonatal outcom e. Protocol in
alexandru.apostol@ downstate.edu developm ent.
Audree Bendo, MD (x3764) The effects of thiopental, propofol and etom idate on regional CBF in
audree.bendo@ downstate.edu critically ill neurosurgical patients by m eans of laser Doppler flowm etry
com bined with a cerebrovascular m onitoring system : Collaboration
with Dr. Juan Botero and Departm ent of Neurosurgery.
Jam es Cottrell, MD (x1935) Studying the ability various anesthetic agents have to protect the brain
jam es.cottrell@ downstate.edu during and after surgery. Perform both in vivo and in vitro studies and
are m ost interested in the m echanism s of brain protection.
Jean Charchaflieh, MD (x3269) Mechanism of anesthetic protection of anoxic brain tissue in the rat
firstname.lastname@example.org hippocam pal slice. Collaboration with Ira Kass, Ph.D.
Ira Kass, PhD (x1709) Studies relating to the understanding of the cellular m echanism s
ira.kass@ downstate.edu which lead to anoxic and ischem ic brain dam age. Devising ways of
interrupting the dam aging pathways, by focusing on exam ination of
the m etabolic, ionic, and electrophysiologic changes during and after
anoxia which m ay trigger the irreversible dam age.
Helen Lauro, MD (780-1707) Studies related to pediatric anesthesia - Propofol infusion syndrom e in
hlauro@ chpnet.org pediatric patients undergoing MRI.
Rebecca S Twersky, MD (780-1350) Preop Beta-Blocker Study- prospective survey of prophylactic
rebecca.twersky@ downstate.edu perioperative beta-blockade use in clinical practice.
Im plem entation of perioperative beta-blockade therapy: a random ized,
controlled trial. Collaboration with Dr. J Fiadjoe.
Lance W agner, MD (x1935) Studies related to bloodless anesthesia. Clinical trial for oxygen as a
lance.wagner@ downstate.edu blood substitute.
Department of Dermatology
Hilary Baldwin, MD (x1229) Clinical trials of various agents affecting keloids and hypertrophic
hilary.baldwin@ downstate.edu scars. Clinical trials in alopecia.
Neil Brody, MD, PhD (x1229) Isolation and characterization of m olecules m ade by tum or cells that
neilbrody@ aol.com alter im m une responsiveness or enhance tum or survival. Studying
effects of sunlight on im m une system .
Sharon Glick, MD (x1229) Projects in pediatric derm atology.
Edward R Heilm an, MD (x1229) Prognostic indicators of m alignant m elanom a.
eheilm an@am eripath.com
W ei-Li Lee, PhD (x2170) Using an in vitro leukocyte-endothelial cell m odel system to evaluate
email@example.com potential anti-inflam m atory properties of com pounds with special
regard for the skin. Studying the effect of antibiotics and anti fungals
on leukocyte activation, cell m orphology and cell functions.
Eve J Lowenstein, MD, PhD (x1229) Projects in derm atology.
Alan R Shalita, MD (x1229) Clinical trials of various agents for treatm ent of acne and related
alan.shalita@ downstate.edu disorders. Microbiology and inflam m ation in acne.
Department of Emergency M edicine
Bonnie Arquilla, DO (270-3216) Disaster Medicine, Surge Capacity Planning, Vulnerable Populations,
Arquibon@aol.com Drill Design and Execution.
Lorenzo Paladino, MD (245-3318) Traum a, Airway.
Richard Sinert, DO (245-2973) Traum a, Hem orrhagic Shock, Asthm a, Diabetes, Hypertension, Renal
richard.sinert@ downstate.edu Failure, Statistics, Evidence-Based Medicine.
Michael B. Stone, MD (245-5595) Em ergency Ultrasound, Medical Student Education, International
drm ikestone@gm ail.com Em ergency Medicine.
Shahriar Zehtabchi, MD (245-4790) Violence Prevention, Traum a, Hem orrhagic Shock, and
firstname.lastname@example.org Evidence-Based Medicine.
Department of Family Practice
Hanna Aghabi, MD (393-0300) Early cancer detection in prim ary care: skin, colon and breast;
hanna.aghabi@ downstate.edu derm atologic procedures in fam ily m edicine.
Margaret Donat, MD (x2560) Preventive care in fam ily m edicine; im m unizations and com plications
m argaret.donat@ downstate.edu in prim ary care.
Aneela Hussain, MD (x3627) Headache and cancer prevention in prim ary care; diabetic neuropathy.
Gloria Mtom boti, MD (x3264) Vaginitis, STD's in prim ary care; thyroid disease in prim ary care.
gloria.m tom boti@ downstate.edu
Richard Sadovsky, MD (x2441) Studies reviewing the ability of a clinical office to enroll entire fam ilies
richard.sadovsky@ downstate.edu and to use entire fam ilies as the focus of treatm ent; effective m edical
writing skills; effective patient education; evaluating patient
understanding of a disease. Sexual health of the older patient.
Pam ela Sass, MD (x2442) Effectiveness of school based directly observed therapy for the
pam ela.sass@ downstate.edu prevention of tuberculosis.
Miriam Vincent, MD (x2443) Appropriateness and standard of care for am bulatory NIDDM
m iriam .vincent@ downstate.edu (Non-Insulin Dependent Diabetes Mellitus); preventive care in fam ily
practice (MTV); alcohol and substance abuse screening in fam ily
practice; influenza and pneum ococcal vaccination: com pliance,
barriers, practice. Osteoporosis screening, evaluation and treatm ent in
prim ary care. Diabetic neuropathy (screening, diagnosis and
Department of M edicine
Abha Agrawal, MD (718-245-3980) Medical inform atics and the use of technology in clinical care,
abha.agrawal@ nychhc.org including design, developm ent and evaluation of clinical inform ation
MaryAnn Banerji, MD (x1542, x1698) Diabetes and cardiovascular disease, diabetes prevention, insulin
m aryann.banerji@ downstate.edu resistance and insulin secretion, HIV and diabetes, endocrinology.
Olcay Batum an, MD (x1500) Molecular m echanism s that regulate angiogenesis (new blood vessel
olcay.batum email@example.com form ation) in m ultiple m yelom a (a com m on blood cell tum or).
Molecular m echanism s that regulate behavioral response to stress.
Moham ed Boutjdir, MD (718-836-6600, Autonom ic regulation of native and heterologously expressed ion
x6070) channels, intracellular signaling, arrhythm ias during ischem ia and
m oham ed.boutjdir@ downstate.edu hypertrophy. Molecular and cellular m echanism s of congenital heart
block in infants born to m others with autoim m une diseases.
Erdal Cavusoglu, MD (x3273) Analysis of FIIR/JAM in patients undergoing coronary angiography.
Luther Clark, MD (x1568) Cardiovascular effects of thiazolidinediones; Effect of HIV infection on
ltclark@ downstate.edu stent restenosis rates; Predictability of the m etabolic syndrom e for
coronary artery disease.
Paul Dreizen, MD (x1155) Molecular m echanism of actom yosin cross-bridge cycle in skeletal
firstname.lastname@example.org and cardiac m uscle and its regulation by tropom yosin. NMR relaxation
studies and m olecular m odeling of protein interactions using m odel
Eli A Friedm an, MD (x1584) Epidem iology of diabetic kidney disease. Blocking diabetic vascular
eli.friedm email@example.com com plications.
Donald A Gerber, MD (x1455) Interaction between lupus-inducing drugs (e.g., hydralazine and
donald.gerber@ downstate.edu procainam ide) and leukocyte oxidants (i.e., hypochlorite and hydrogen
peroxide) and the effect of this interaction on protein structure.
Ellen M Ginzler, MD, MPH (x2529) Long-term , prospective study of the clinical course, prognosis and
ellen.ginzler@ downstate.edu response to therapy in a large cohort of patients with system ic lupus
erythem atosus. Specific studies have been done related to lupus
nephritis, prem ature atherosclerosis, and com plications of therapy.
A Ross Hill, MD (x1770) Clinical studies on TB, e.g., retrospective case series and prospective
ross.hill@ downstate.edu study involving patients in DOT (directly observed therapy) program .
Longstanding interest in respiratory physiology (m echanics, resp.
m uscles, control of breathing).
Rauno O Joks, MD (x1662) Anti-inflam m atory properties of tetracycline antibiotics. Role of
rauno.joks@ downstate.edu com plem ent proteins in allergic diseases.
Martin Kram er, MD (x3996) Clinical studies in infection control at Kings County Hospital.
m artin.kram er@ nychhc.org
David Landm an, MD (x3790) Investigations include m olecular epidem iology of nosocom ial
david.landm firstname.lastname@example.org infections and studies involving the m echanism s of antibiotic
resistance; evaluations of the activity of new investigational
com pounds are also conducted.
Sheldon Landesm an, MD (x3034) Prospective study of HIV infected pregnant wom en and their offspring,
sheldon.landesm email@example.com the natural history of perinatally acquired HIV, the effect of retrovirals
on cardiac function and the developm ent of m itochondrial syndrom es
Jason Lazar, MD (x1568) Alcoholic cardiom yopathy; effect of action potential duration in
jason.lazar@ downstate.edu ischem ia.
W illiam M McCorm ack, MD (x1432) Evaluation of diagnostic tests for and treatm ent of sexually transm itted
bill.m ccorm ack@ downstate.edu and other genitourinary infections.
Allen J Norin, PhD (x2516) Role of the novel vesicle associated gene product, "Haym aker," in
allen.norin@ downstate.edu growth and differentiation of norm al and m alignant cells.
Receptor-ligand interactions involved in cytolytic lym phocyte
destruction of tum or cells and organ grafts, in particular, the role of
"Haym aker" and its cognate receptor in Natural Killer lym phocyte
m ediated cytotoxicity. Diagnosis of allograft rejection using (I)
m olecular probes of lym phocyte activation and (2) optical bead
m icroarrays / Lum inex for detection of anti HLA antibodies.
Louis Salciccioli, MD (x1568) The use of brain natriuretic peptide in assessing the severity of
louis.salciccioli@ downstate.edu coronary artery disease.
Man Seok Oh, MD (x1565) W hole body acid-base balances.
Edward Quadros, PhD (x4203) Molecular, genetic and biochem ical aspects of Vitam in B12
edward.quadros@ downstate.edu m etabolism . Purification and cloning of vitam in B12 binding proteins
and their receptors. Transcobalam in II and the receptor for
Transcobalam in II-Cobalam in as targets for new cancer therapeutics.
John Quale, MD (x) Investigations include m olecular epidem iology of nosocom ial
john.quale@ downstate.edu infections and studies involving the m echanism s of antibiotic
resistance; evaluations of the activity of new investigational
com pounds are also conducted.
TK Sreepada Rao, MD (x1394) AIDS and kidney disease; erythropoietin in kidney disease.
W illiam B Solom on, MD (x1333) Protein:DNA interactions; Cloning of novel hem atopoietic m RNAs.
william .solom firstname.lastname@example.org
Steven M W eiss, MD (x4181) Investigating the possible relationships between Chlam ydia
weisss@ nychhc.org pneum oniae infection and atherosclerosis and asthm a.
Department of Neurology
Charles K. Abram s, MD, PhD (x1270) My lab studies m echanism s of hum an central and peripheral nervous
charles.abram s@ downstate.edu system diseases associated with m utations in connexins (gap junction
proteins). I also study the roles of gap junctions in peripheral nerve
regeneration and inherited peripheral neuropathy.
Brian J Anziska, MD (x2502) Com parison of neurology undergraduate education in different
brian.anziska@ downstate.edu m edical schools using param eters such as overnight calls, and
exam ination m odalities.
Yaacov Anziska, MD (x2734) HIV and toxic neuropathies, peripheral nerve injuries.
Chun Bai, MD (x2883) Sleep disorders and its im pact on cognitive and neurological function,
chun.bai@ downstate.edu circadian rhythm disorder, sleep breathing disturbance; epidem iology
and prevalence in m inority population.
Alison Baird, MD (x3213) Studying the predictors of clinical and tissue outcom e after stroke and
alison.baird@ downstate.edu predictors of stroke risk. Methods used include neurovascular
im aging (MRI, MRA, and CT) and cellular and m olecular profiling of
the peripheral blood (gene expression profiling and flow cytom etry).
Developm ent and evaluation of novel diagnostic and therapeutic
approaches for stroke.
Satyakam Bhagavati, MD (x2841) Skeletal m uscle generation from em bryonic stem cells: Isolation of
satyakam .bhagavati@ downstate.edu skeletal m uscle stem cells from m urine em bryonic stem cells, studying
their in vitro differentiation and proliferation characteristics and their
ability to generate physiologically norm al skeletal m uscle after
transplantation into dystrophic m ice.
Ivan Bodis-W ollner, MD (x2975) Vision and visual cognition suffer in dopam inergic deficiency states,
ivan.bodis-wollner@ downstate.edu such as in Parkinson's disease (PD). Our research studies evaluate
electrophysiological neural network properties of dopam inergic circuits
m ediating vision, saccadic eye m ovem ents and visual cognition. In
addition, we study retinal im pairm ent in PD, using optical coherence
tom ography, an in vivo im aging technique of the retina.
Geetha Chari, MD (x2959) Epilepsy clinical studies.
Roger Q Cracco, MD (x2051) Magnetic stim ulation of nervous system .
Joan Cracco, MD (x2035) Mechanism s of long term potentiation.
Howard Crystal, MD (x2748) Cognitive changes in HIV. Genetics of substance abuse in HIV.
howard.crystal@ downstate.edu Com putational m odels of working and procedural m em ory.
Radha Giridharan (x2042) Strokes in sickle cell disease. Clinical research in pediatric neurology
Patricia Kavanagh, MD (718-403-9855) Clinical m ovem ent disorders studies, including Parkinson's disease,
patricia.kavanagh@ downstate.edu dystonia, essential trem or, and atypical parkinsonism .
Paul J Maccabee, MD (x2430) Physical m odeling, in vitro studies of nerve excitation using
paul.m accabee@ downstate.edu neurom agnetic stim ulation. Developing clinical m ethods to detect
abnorm alities in the cauda equina and also the entire neuroaxis.
Alexander Mauskop, MD (718-935-9666) Ionized m agnesium and headaches.
alexander.m auskop@ downstate.edu
Lisa Merlin, MD (x3957) Hippocam pal electrophysiology: exam ination of the role of
lisa.m erlin@ downstate.edu m etabotropic glutam ate receptors in seizure production and
epileptogenesis, with the aim to develop ways to prevent epilepsy in
at-risk patients and suppress seizures in refractory patients.
Herm an Moreno, MD (x1338) Use of fMRI in m ouse m odels of neurodegenerative disease such as
herm an.m email@example.com Alzheim er's and Down’s syndrom e to study brain m etabolism , as an
early m arker of the disease. Basic electrophysiology and single cell
calcium signaling to study brain circuit abnorm alities in
neurodegenerative disease in m ultiple m ouse m odels.
Arthur L. Rose, MD (x3209) Fragile-X syndrom e: Mode of action of FMRP in the central nervous
firstname.lastname@example.org system and the m echanism of "toxic" FMR1 m RNA activity in carriers.
Daniel Rosenbaum , MD (x2051) The focus of the lab is to study the underlying m echanism s of
daniel.rosenbaum @ downstate.edu ischem ic cell death. By obtaining a better understanding of the events
that occur at a m olecular level, therapies aim ed at reducing neuronal
dam age m ay be developed. Specifically, we are focusing on the role
of apoptosis in neuronal ischem ia. The laboratory utilizes both
cerebral and retinal m odels. Another area of focus is neural stem and
progenitor cells. The adult m am m alian brain contains neural stem and
progenitor cells that can proliferate, self-renew, and generate all of the
cellular elem ents of the brain including neurons. During the past few
years techniques have been developed that m ake it possible to isolate
and expand, from developing or even adult CNS tissue, cells with
properties characteristic of early neural m ultipotent progenitor or stem
cells. These techniques have opened interesting new possibilities for
the use of cells for CNS transplantation, neural replacem ent, and
brain repair. This project will bring the rapidly expanding area of
progenitor cells to bear on the problem s of stroke and cerebral
Sophia Sharfstein, MD (x2035) Stroke studies.
Helen Valsam is, MD (x1356) Investigations on the prevention of post-traum atic epilepsy.
helen.valsam is@ downstate.edu
Department of Neurosurgery
Experim ental research: Molecular m echanism s of neuroprotection.
Ethan A. Benardete, MD, PhD (X4335)
Clinical research: Outcom es in cerebrovascular and skull base
Maria Li, MD (X2111)
m aria.li@ downstate.edu
Stephen T Onesti, MD (X2111) Spinal neurosurgery, m inim ally invasive spine surgery, cervical
stephen.onesti@ downstate.edu degenerative disc disease and surgical treatm ents for chronic pain.
Brain tum ors, aneurysm s, vascular m alform ations, peripheral nerve
Nicholas Post, MD (X2111)
surgery, spinal cord tum ors, tum ors of the spinal colum n, spinal
Ali Sadr, MD (X4141)
Neurosurgery; Skull Base Surgery; Neurotraum a.
Mark Thom pson, MD (X4141)
Spinal neurosurgery and spine traum a.
m ark.thom email@example.com
Department of Obstetrics & Gynecology
Ovadia Abulafia, MD (x2057) Throm bophilia in gynecologic m alignancies; Album in levels as
ovadia.abulafia@ downstate.edu prognosticators of risk in gynecologic m alignancies; Adequacy of
hysterectom y in patients with positive endocervical curettage;
incidence of BRCA1 and BRCA2 in African-Am erican wom en with
Vijaya Nacharaju, PhD (x2064) Estrogen and progesterone m etabolites in urine and saliva, 11beta
vijaya.nacharaju@ downstate.edu steroid dehydrogenase and arom atase in endom etrial carcinom a.
John Rasweiler, PhD (x2057) Angiogenesis in the m am m alian endom etrium .
Department of Ophthalmology
Monica Dweck, MD (x1961) Lacrim al and orbital disease.
m onica.dweck@ downstate.edu
Jeffrey Freedm an, MD, PhD (x1961) Elucidation of the m echanism s of inflam m atory fibrosis in glaucom a.
Douglas Lazzaro, MD (x3380) Corneal research.
E.C. Lazzaro, MD (x1962) Ophthalm ic m anifestations of syphilis.
Arthur W olintz, MD (x1961) Ocular m anifestation of neurologic disease.
Department of Orthopedic Surgery & Rehabilitation M edicine
Sanjeev Agarwal, MD (x1892) Interventional physiatry and pain m anagem ent.
Tsai Chao, MD (x1892) Physical m edicine and rehabilitation, acupuncture.
Michael Gerling, MD (x3200) Spine surgery; whiplash injury; vertebroplasty and kyphoplasty;
m firstname.lastname@example.org m inim ally invasive spinal procedures; degenerative diseases of the
neck and back; traum atic spinal injuries of the neck and back.
Pam ela Levine, MD (x2055) Hand surgery; nerve injury; hand and upper extrem ity surgery; wrist
pam email@example.com and elbow arthroscopy; m icro-surgical techniques.
Seung Park, MD (x1892) Physical m edicine and rehabilitation.
Carl Paulino, MD (x3200) Scoliosis and deform ity, total disc replacem ent, spine surgery.
Paul Pipia, MD (x1892) Physical m edicine and rehabilitation; orthotics and prosthetics.
Vijay Rasquinha, MD (x3200) Total hip and knee replacem ents; im plant retrieval analysis.
Soon Rho, MD (x1892) Physical m edicine and rehabilitation, electrom yography.
Subrata Saha, PhD (x8652) Biom echanics of m usculoskeletal system ; biom aterials; sports injury;
firstname.lastname@example.org electrical stim ulation for bone healing; osteoporosis; orthopedic
im plant testing; m echanical properties of bone and bone cem ent;
bioethics; health care delivery.
Claude Scott, MD, PhD (x2055) Pediatric orthopedic and traum a research; hip and lower extrem ity
claude.scott@ downstate.edu deform ities; gait disturbances; neurom uscular disorders; pediatric
John Sharkey, MD (x4673) Sports m edicine, arthroscopic surgery, shoulder and knee surgery.
Charles R Spero, MD (x2055) Pediatric fractures; congenital and developm ental deform ities of the
charles.spero@ downstate.edu hip and lower extrem ity; gait disturbances; neurom uscular disorders.
W illiam Urban, MD (x2055) Sports m edicine studies; athletic injuries; strength of sutures; ligam ent
william .email@example.com biom echanics; arthroscopic surgery; shoulder and knee surgery.
Department of Otolaryngology
Nira Goldstein, MD (x1638) The diagnosis of pediatric obstructive sleep apnea. Im pact of
nira.goldstein@ downstate.edu tonsillectom y and adenoidectom y on child behavior.
Gady Har-El, MD (x1638) Head and neck cancer. Surgical approaches to skull base tum ors.
Reconstructive techniques after head and neck cancer surgery. Deep
Jessica W Lim , MD (x1638) Effect of endoscopic sinus surgery and m iddle turbinate positioning on
jessica.lim @ downstate.edu olfaction. Tracheotom y in the elderly patient.
Joseph R McPhee, PhD (x2350) Molecular genetic basis of otosclerosis. The use of high frequency
joseph.m firstname.lastname@example.org otacoustic em issions in the m onitoring of early-stage ototoxicity.
Collagen rem odeling and keloid form ation. Strom elysin expression in
head and neck carcinom a.
Richard Rosenfeld, MD (x1638) Quality of life research. Meta-analysis. Otitis m edia.
Neil Sperling, MD (x1638) Distortion product otoacoustic em issions applied to hearing loss.
Quality of life aspects of chronic infectious ear disease.
Department of Pediatrics
Stacy Blain, PhD (x4471) Cell cycle progression, focusing on the cyclin cdks and their inhibitors,
stacy.blain@ downstate.edu Cip/Kips.
Shirley Chang Electron m icroscopy of pediatric kidney disease.
Salvador Castells, MD (x2962) Evaluation of insulin dependant diabetics with oral glucose tolerance
salvador.castells@ downstate.edu tests for hypothalam ic dysfunction in children with Down’s syndrom e
and hum an growth horm one therapy.
Margaret Clark-Golden, MD, MPH (x2132) Risk factors for pediatric injury, both intentional and non-intentional;
m email@example.com lead poisoning; nutrition.
Stanley Fisher, MD (x1625) Our research studies the cell biology of placental function. In
stanley.fisher@ downstate.edu particular, we are interested in the effects of ethanol exposure on cell
signal transduction and downstream transcriptional/translational
Margaret R Ham m erschlag, MD Current research is concentrated on the epidem iology, im m unology,
(245-4074) diagnosis and treatm ent of infections due to Chlamydia pneumoniae.
m argaret.ham m firstname.lastname@example.org This includes investigation of the relationship to reactive airway
disease, at cytokine production, m ouse m odel of C. pneumoniae
infection and atherosclerosis, reactive airway disease. Antibiotic
treatm ent trials. Diagnosis and treatm ent of C. trachomatis infections
in infants and adolescents. Sexually transm itted diseases and sexual
Robert Karp, MD (245-3612) Nutrition, lead poisoning: relation of im m unization status to physical
robert.karp@ downstate.edu growth, hem atologic status and lead level.
Scott T Miller, MD (x1692) Clinical/psychosocial aspects of pediatric sickle cell disease.
scott.m iller@ downstate.edu
Madu Rao, MD (x1524) Asthm a: epidem iology, m ortality trends in Brooklyn. Sleep: obstructive
m email@example.com sleep apnea in children - dem ographics, pulm onary hypertension lung
physiology in sicklers prone to lung disease (consultant for national
Sreedhar Rao, MD (x1692) Clinical expression of big parvovirus on children with sickle cell
firstname.lastname@example.org disease and in children with AIDS. Pneum ococcal antibodies in
children and adolescent with sickle cell disease. Role of booster
im m unizations with pneum ococcal vaccine. Radionuclide im aging and
MR im aging of bones in sickle cell disease.
Am y Suss, MD (x1625) Hepatitis B&C in adolescents. New treatm ents for chlam ydia in
am y.suss@ downstate.edu adolescents. Suicide attem pts in adolescents.
Department of Preventive M edicine and Community Health
Jack A DeHovitz, MD (x1069) Prospective studies of HIV-infected wom en.
Joseph Feldm an, DPH (x1080) Prognosis of breast cancer; natural history of HIV infection; cancer
joseph.feldm email@example.com epidem iology; epidem iologic m ethods.
Pascal J Im perato, MD (x1056) Clinical outcom es research. Population studies.
pascal.im perato@ downstate.edu
Judith H LaRosa, PhD (x3204) Public health aspects of wom en's health, cardiovascular disease,
firstname.lastname@example.org com m unity health, and sex/gender differences in health.
Tracey E. W ilson, PhD (x3746) Behavioral intervention and evaluation research, HIV/STI prevention,
email@example.com behavioral issues related to wom en's sexual and reproductive health.
Department of Psychiatry
Michael Berzofsky, PhD (x2004) Research is focused on change in psychotherapy in brief hospital
m ichael.berzofsky@ downstate.edu treatm ent. Focus is on how patients engage or resist the treatm ent
process to subjectively describe their inner world and experiences.
Miranda Chakos, MD (x1748) Studying the effectiveness of new treatm ents for schizophrenia,
m iranda.chakos@ downstate.edu including treatm ent of cognitive im pairm ent and negative sym ptom s in
schizophrenia. Studying the effect of antipsychotic m edication on the
m etabolic syndrom e.
Carl Cohen, MD (287-4806) Research on anxiety and depression of older Afro-Am ericans and
firstname.lastname@example.org Afro- Caribbeans residing in Brooklyn. Evaluation of m inority dem entia
patients and their caregivers. Schizophrenia and aging: com parison of
Afro-Am ericans and Caucasians living in nursing hom es.
Jerem y Coplan, MD (x2022) Nonhum an prim ate m odels of early life stress as pertains to hum an
email@example.com depression and anxiety disorders, using diffusion tensor im aging,
m agnetic resonance spectroscopy, neuroendocrine CSF profiles
including corticotropin releasing-factor, HPA axis and gene
expression. Investigating the role of neurogenesis in antidepressant
action in nonhum an prim ate m odels of depression. Perform ing rodent
studies focused on the role of neurogenesis and segregation.
Perform ing clinical studies in patients with bipolar depression and
Daniel Cukor, PhD (x2077) Behavioral m edicine research. Cognitive behavioral intervention in
daniel.cukor@ downstate.edu chronic renal disease, non-com pliance and developm ent of
depression treatm ent for the chronically ill.
Steven Friedm an, PhD, ABPP (x1750) Cross-cultural issues in the diagnosis and treatm ent of anxiety
steven.friedm firstname.lastname@example.org disorders. Sexual dysfunctions.
Michael Garrett, MD (x2022) Clinical research exam ining the phenom enology of psychosis and lack
m ichael.garrett@ downstate.edu of insight in m ental illness, with em phasis on auditory hallucinations.
Psychoanalytic conceptions of psychosis. Cognitive behavioral
treatm ent of schizophrenia.
Am jad Hindi, MD (x2022) Interest prim arily in schizophrenia research; this includes: first episode
am jad.hindi@ downstate.edu schizophrenia and effectiveness of antipsychotic treatm ent; chronic
schizophrenia and effectiveness of m edications; schizophrenia in the
elderly and quality of life and general health issues; and finally the
subjective ethnography of patients with schizophrenia.
Bernice Porjesz, PhD (x2911) Neurophysiology of brain function in hum ans. Genetics of brain
bernice.porjesz@ downstate.edu function. Genetic study of alcoholism and related disorders.
Ram otse Saunders, MD (x3077) Neurophysiology in hum ans. Utilization of event-related potentials and
ram otse.saunders@ downstate.edu event-related oscillations in various experim ental paradigm s.
Nina R Schooler, PhD (917-543-2740) Clinical trials of m edications for schizophrenia. Developm ent of a
nina.schooler@ downstate.edu novel assessm ent m ethod for assessing psychopathology in
schizophrenia. Studies of m edication adherence.
Ram aswam y Viswanathan, MD, Dsc Decisional capacity; death anxiety and coping; ethical conflicts in
(x2313) m edicine and resolution.
ram aswam email@example.com
Department of Radiation Oncology
Kwang N Choi, MD (x1591) Continuous infusion chem otherapy with hyperfractionated irradiation
kwang.choi@ downstate.edu for locally advanced cancers. Com bined chem otherapy and irradiation
in cancer treatm ents.
Christopher Lange, DPhil (x1050) Cellular basis of organism al radiation: lethality and aging. Cellular
firstname.lastname@example.org radiation lethality in term s of DNA DSB repair kinetics. Chrom osom e
structure-DNA organization. Physical chem ical/biophysical m ethods
for DNA size m easurem ent.
Marvin Rotm an, MD (x2181) Clinical trials with the Radiation Therapy Oncology Group. Gynecology
m arvin.rotm email@example.com Oncology Groups: chem otherapy and radiation.
Department of Radiology
Brian Gale, MD (x1603) Medical inform atics. Intraoperative sentinel node analysis by nuclear
brian.gale@ downstate.edu m edicine agents (m onoclonal antibodies). Ultrasonography of the
endom etrium . Com puters in m edicine.
Michael Herskowitz, MD (x1996) Studying patency of dialysis grafts after throm bolysis. Also studying
m ichael.herskowitz@ downstate.edu patency of dialysis grafts after placing m etallic stent prosthesis at sites
of recurrent stenosis.
Sundeep Mangla, MD (x4141) Intracranial aneurysm s (im aging, public health, therapy); brain
sundeep.m angla@ downstate.edu arteriovenous m alform ations (im aging, public health, therapy);
cerebrovascular occlusive disease, angioplasty and stenting; robotics,
endolum inal diagnosis and intervention; acute stroke and cerebral
perfusion (im aging, physiology, and therapy); nanotechnology and
biom edical engineering; prospective outcom es research; basic
translational research; radiologic im aging research, prospective and
Salvatore Sclafani, MD (245-4447) The study of new technologies, such as em bolization, to control
salvatore.sclafani@ downstate.edu traum atic hem orrhage. Evaluation of Corvita stent grafts for abdom inal
aortic aneurysm repair.
Arnold Strashun, MD (x1632) Intraoperative sentinel node analysis by nuclear m edicine agents
firstname.lastname@example.org (m onoclonal antibodies). Evaluation of tinnitus and evaluation of
m igraine with cerebral perfusion scintigraphy. Scintigraphic evaluation
of en bloc cadaveric double renal transplants.
Daniel L Zinn, MD (x2552) Use of Doppler (Color and Power) in testicular torsion analysis.
email@example.com Medical education through m edical and diagnostic im aging.
Harry L Zinn, MD (x1603) Topics in genitourinary cross-sectional im aging.
Department of Surgery
Joshua Burack, MD (x1981) Mediastinal traum a; endocarditis; graft infection; socio-econom ic
joshua.burack@ downstate.edu factors and access to health care in cardiac surgery.
Dale A Distant, MD (x1898) Im m unosuppression in renal transplantation; diabetic urem ia.
Lisa S Dresner, MD (x1953) Critical care; m icrovascular reactivity.
W ilson Ko, MD (x1981) The focus of clinical research of the division is on the risk reduction of
wilson.ko@ downstate.edu cardiac surgery in patients with special needs. Current projects
include (1) the use of recom binant clotting factor VIIa to treat severe
coagulopathy after cardiopulm onary bypass, (2) the use of a novel
bedside ultrafiltration technique in the treatm ent of acute renal failure
after cardiac surgery, (3) pulsatile cardiopulm onary bypass to reduce
the risk of renal deterioration of patients with chronic renal
insufficiency, (4) the m echanism of m yocardial ischem ia-reperfusion
injury, (5) novel real tim e diffuse near infrared optical im aging of brain
perfusion during cardiopulm onary bypass, (6) perioperative glycem ic
control of diabetic and non-diabetic cardiac surgery patients, and (7)
genetic analysis of m yocardial biopsy from patients with aortic
stenosis and regurgitation. Collaborations are ongoing with
cardiology, anesthesiology, biom edical engineering, and pathology.
John G Kral, MD, PhD (x1955) Insulin resistance m etabolic syndrom e; obesity, diabetes; adipose
john.kral@ downstate.edu tissue; insulin resistance; vagal function.
Daniel Lee, MD (x1981) Brain perfusion by diffuse optical tom ography during cardiac surgery
firstname.lastname@example.org with cardiopulm onary bypass.
Theophilus Lewis, MD (x2155) Nutrition support.
Patricia O'Neill, MD (x1973) Antibiotic prophylaxis.
Jam es Reilly, MD (x2439) Mathem atical m odeling; decision analysis.
Nabil Sum rani, MD (x1898) Renal transplantation and diabetes.
nabil.sum rani@ downstate.edu
Michael Zenilm an, MD (x1973) Physiology of pancreatic regeneration; m olecular genetics; advanced
m ichael.zenilm email@example.com laparoscopic and pancreatic surgical technique; surgery in the elderly.
Department of Urology
Mark Horowitz, MD (x2554) Clinical research in pediatric urology.
m ark.horowitz@ downstate.edu
Richard J Macchia, MD (x2554) The departm ent is engaged in a broad range of clinical research
richard.m acchia@ downstate.edu involving all aspects of general and pediatric urology. Topics include
various aspects of BPH, prostate cancer, laparoscopic surgery,
voiding dysfunction, sexual dysfunction, com m unity
outreach/education program s, and other areas.
OTHER COLLEGE OF M EDICINE DEPARTM ENTS
Division of Laboratory Animal Resources
Sam uel R Adam s, DVM (x1194) Im provem ent of anim al resources. Developm ent, im provem ent and
sam uel.adam s@ downstate.edu refinem ent of anim al m odels.
Division of Hum anities in M edicine
Alice Herb, JD, LLM (x3780) Clinical ethics, health law, patient advocacy, research ethics.
Kathleen E Powderly, PhD (x3322) Ethical and legal issues in HIV disease. Ethical issues for first
kathleen.powderly@ downstate.edu responders in the era of terrorism ; history of m edicine; perinatal
** Unless otherwise noted, phone numbers are at the (718) 270- exchange **