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Supplementary file S5. Haapa-Paananen et al.

                                   Top30 BioFunctions after silencing of HES6 (all siRNAs, two cell lines)
Category                  Functions           Function Annotation              p-value    # Genes Molecules
Inflammatory Response     immune response     immune response                  7.07E-05      29   ADM, APOBEC3F, APOBEC3G, CASP1, CCL5, CEACAM1, CXCL10, DDX58, DLL1, ERAP2, GBP2, GEM, HLA-B, HSP90B1, IDO1, IER3, IFIH1, IFNB1, IL18, IL29, LIPA,
                                                                                                      PSMB8, TAP1, TLR3, TNFSF10, TNFSF13B, TRIM22, UNC93B1, XBP1
Inflammatory Disease      inflammatory        inflammatory disorder of         7.56E-05      20       C1R, C1S, CASP1, CCL5, CEACAM1, CXCL10, DLL1, HLA-B, HSPA5, IDO1, IFNB1, IGFBP3, IL18, TAP1, TGFBR2, TGM2, TLR3, TNFSF10, TNFSF13B, UNC93B1

                          disorder            mammalia
Cellular Development      developmental       developmental process of         1.33E-05      32       ABL2, ADM, CASP1, CD82, CDK5R1, CEACAM1, FOXC1, GDF15, GEM, GRN, HOXA5, HOXC6, HSPA5, IDO1, IER3, IFNB1, IGFBP3, IL18, ITGB1, LOX, NFS1, PMEPA1,
                                                                                                      SFRS5, SIAH1, TGFBR2, TGM2, TMEM49, TNFSF10, TPM1, TWIST1, WNT5A, XBP1
                          process             tumor cell lines
                          growth              growth of tumor cell lines       4.59E-05      26       ADM, CASP1, CEACAM1, FOXC1, GDF15, GRN, HOXC6, HSPA5, IDO1, IER3, IFNB1, IGFBP3, IL18, ITGB1, LOX, NFS1, PMEPA1, SFRS5, SIAH1, TGFBR2, TMEM49,
                                                                                                      TNFSF10, TPM1, TWIST1, WNT5A, XBP1
Cellular Development      maturation          maturation of cells              2.73E-04      15       CCL5, E2F2, HSP90B1, IFIH1, IFNB1, IL18, IL29, ITGB1, LFNG, RARRES3, TGFBR2, TLR3, TNFSF10, TNFSF13B, XBP1

                          development         development of cells             1.18E-03      36       ABL2, ADM, ASB1, CASP1, CCL5, CD82, CDK5R1, DAGLB, DLL1, E2F2, EFNA1, FOXC1, GEM, HOXA5, HSP90B1, IDO1, IER3, IFNB1, IL18, ITGB1, LFNG, LIPA, LMO2, LOX,
                                                                                                      OPTN, PSMB8, SNAI2, STAM, TDRD7, TGFBR2, TGM2, TLR3, TNFSF10, TNFSF13B, TPM1, XBP1
Cellular Growth and       growth              growth of eukaryotic cells       2.39E-05      38       ABL2, ADM, CASP1, CD82, CEACAM1, CXCL10, DLL1, E2F2, EFNA1, FOXC1, GBP2, GDF15, GEM, GRN, HOXC6, HSPA5, IDO1, IER3, IFNB1, IGFBP3, IL18, IL29, ITGB1,
                                                                                                      LOX, NFS1, PMEPA1, PNN, SFRS5, SIAH1, TGFBR2, TLR3, TMEM49, TNFSF10, TNFSF13B, TPM1, TWIST1, WNT5A, XBP1
Proliferation                                                                                         ADM, AFAP1, ARID3A, CASP1, CCL5, CDK5R1, CEACAM1, CXCL10, CXCL16, DLL1, E2F2, E4F1, EFNA1, GABPB2, GAS1, GBP1 (includes EG:2633), GDF15, GRN, HLA-E,
                          proliferation       proliferation of eukaryotic      3.67E-04      47
                                                                                                      HOXA5, HOXC6, HSP90B1, HSPA5, IDO1, IER3, IFNB1, IGFBP3, IGFBP6, IL18, IL29, IL4I1, ISG20, ITGB1, LOX, NT5C3, NT5E, RALB, RARRES3, SCPEP1, SNAI2, STAM,
                                              cells                                                   TGFBR2, TGM2, TLR3, TNFSF10, TNFSF13B, WNT5A
                          proliferation       proliferation of cells           2.83E-03      52       ADM, AFAP1, ARID3A, CASP1, CCL5, CDK5R1, CEACAM1, CLK1, CXCL10, CXCL16, DLL1, E2F2, E4F1, EFNA1, GABPB2, GAS1, GBP1 (includes EG:2633), GDF15, GRN,
                                                                                                      HLA-E, HOXA5, HOXC6, HSP90B1, HSPA5, IDO1, IER3, IFNB1, IGFBP3, IGFBP6, IL18, IL29, IL4I1, INSIG1, ISG20, ITGB1, LIPA, LOX, NOP2, NT5C3, NT5E, RALB,
                                                                                                      RARRES3, SCPEP1, SNAI2, STAM, TGFBR2, TGM2, TLR3, TNFSF10, TNFSF13B, WARS, WNT5A
Cancer                    cancer              cancer                           2.42E-05      75       ABL2, ACTA2, AFAP1, C12ORF24, C1R, C1S, CALD1, CASP1, CCL5, CD68, CD82, CEACAM1, CLK1, COL1A2, CSTF3, CXCL10, CXCL16, E2F2, EFNA1, EIF4A2, EPM2AIP1,
                                                                                                      ERAP2, FAM171A1, FBXL2, FOXC1, GAS1, GBP2, GBP1 (includes EG:2633), GDF15, GEMIN4, GRN, HLA-B, HLA-E, HNRPDL, HOXA5, HOXC6, HSP90B1, HSPA5, IDO1,
                                                                                                      IER3, IFIH1, IFIT3, IFNB1, IGFBP3, IL18, IL18BP, INSIG1, ISG20, ITGB1, LGALS3BP, LMO2, LOX, MAT2A, MRPL34, NCOA7, NOL12, NT5E, PDGFRL, PDIA6, PLSCR4,
                                                                                                      PPP1R3C, RBM4B, SCARB2, SFRS5, SIAH1, SNAI2, TAGLN, TGFBR2, TLR3, TNFSF10, TOMM34, TPM1, TWIST1, WARS, WNT5A

                          tumorigenesis       tumorigenesis                    5.61E-05      79       ABL2, ACTA2, AFAP1, ARID3A, C12ORF24, C1R, C1S, CALD1, CASP1, CCL5, CD68, CD82, CEACAM1, CLK1, COL1A2, CSTF3, CXCL10, CXCL16, E2F2, EFNA1, EIF4A2,
                                                                                                      EPM2AIP1, ERAP2, FAM171A1, FBXL2, FOXC1, GAS1, GBP2, GBP1 (includes EG:2633), GDF15, GEMIN4, GRN, HLA-B, HLA-E, HNRPDL, HOXA5, HOXC6, HSP90B1,
                                                                                                      HSPA5, IDO1, IER3, IFIH1, IFIT3, IFNB1, IGFBP3, IL18, IL18BP, INSIG1, ISG20, ITGB1, LGALS3BP, LMO2, LOX, MAT2A, MRPL34, NCOA7, NOL12, NT5E, PDGFRL, PDIA6,
                                                                                                      PLA2G16, PLSCR4, PPP1R3C, RALB, RBM4B, SCARB2, SFRS5, SIAH1, SNAI2, TAGLN, TGFBR2, TLR3, TNFSF10, TNFSF13B, TOMM34, TPM1, TWIST1, WARS, WNT5A


Neurological Disease      neurological        neurological disorder of         8.82E-03      20       CASP1, CDK5R1, CXCL10, DLL1, HLA-B, HSP90B1, HSPA5, IDO1, IFNB1, IL18, ITGB1, MAP3K4, NT5E, STX1A, TGM2, TLR3, TNFSF10, UNC93B1, VGF, XBP1

                          disorder            mammalia
Cell Death                apoptosis           apoptosis                        1.47E-04      56       ABL2, ADM, APBB3, CASP1, CCL5, CDK5R1, CEACAM1, DDX58, DIDO1, DLL1, E2F2, EFNA1, FSTL1, GAS1, GDF15, GFPT1, GRN, HLA-B, HOXA5, HOXC6, HSPA5, IDO1,
                                                                                                      IER3, IFIH1, IFNB1, IGFBP3, IGFBP6, IL18, ITGB1, ITM2B, LGALS3BP, MAP3K4, OAS1, OPTN, PLA2G16, PMEPA1, PTRH2, RALB, RBM4B, SFRS5, SH3KBP1, SIAH1,
                                                                                                      SNAI2, STX1A, TGFBR2, TGM2, TLR3, TMEM107, TMX1, TNFSF10, TNFSF13B, TPM1, TWIST1, WNT5A, XBP1, ZFAND5
                          apoptosis           apoptosis of tumor cell lines    1.63E-04      31       ADM, CASP1, CDK5R1, CEACAM1, DLL1, E2F2, GDF15, GRN, HOXA5, HOXC6, HSPA5, IDO1, IER3, IFNB1, IGFBP3, IGFBP6, IL18, ITGB1, LGALS3BP, MAP3K4, PLA2G16,
                                                                                                      PMEPA1, PTRH2, RALB, RBM4B, SIAH1, TGM2, TNFSF10, TNFSF13B, TWIST1, XBP1
                          apoptosis           apoptosis of eukaryotic cells    2.99E-04      47       ABL2, ADM, CASP1, CCL5, CDK5R1, CEACAM1, DLL1, E2F2, EFNA1, FSTL1, GDF15, GFPT1, GRN, HLA-B, HOXA5, HOXC6, HSPA5, IDO1, IER3, IFIH1, IFNB1, IGFBP3,
                                                                                                      IGFBP6, IL18, ITGB1, LGALS3BP, MAP3K4, PLA2G16, PMEPA1, PTRH2, RALB, RBM4B, SFRS5, SH3KBP1, SIAH1, SNAI2, STX1A, TGFBR2, TGM2, TMEM107, TMX1,
                                                                                                      TNFSF10, TNFSF13B, TPM1, TWIST1, WNT5A, XBP1
                          cell death          cell death of tumor cell lines   1.55E-04      35       ADM, CASP1, CDK5R1, CEACAM1, DLL1, E2F2, GDF15, GRN, HOXA5, HOXC6, HSPA5, IDO1, IER3, IFNB1, IGFBP3, IGFBP6, IL18, IL29, ITGB1, LAMP2, LGALS3BP,
                                                                                                      MAP3K4, MEF2D, PLA2G16, PMEPA1, PTRH2, RALB, RBM4B, SIAH1, TGM2, TMEM123, TNFSF10, TNFSF13B, TWIST1, XBP1
                          cell death          cell death                       2.45E-04      63       ABL2, ADM, APBB3, CASP1, CCL5, CD82, CDK5R1, CEACAM1, DDX58, DIDO1, DLL1, E2F2, EFNA1, FSTL1, GAS1, GDF15, GFPT1, GRN, HLA-B, HOXA5, HOXC6, HSPA5,
                                                                                                      IDO1, IER3, IFIH1, IFNB1, IGFBP3, IGFBP6, IL18, IL29, ITGB1, ITM2B, LAMP2, LGALS3BP, MAP3K4, MEF2D, OAS1, OPTN, PLA2G16, PMEPA1, PTRH2, RALB, RBM4B,
                                                                                                      SFRS5, SH3KBP1, SIAH1, SNAI2, STAM, STX1A, TGFBR2, TGM2, TLR3, TMEM107, TMEM123, TMX1, TNFSF10, TNFSF13B, TPM1, TWIST1, VAMP3, WNT5A, XBP1,
                                                                                                      ZFAND5

                          cell death          cell death of eukaryotic cells   3.50E-04      54       ABL2, ADM, CASP1, CCL5, CDK5R1, CEACAM1, DLL1, E2F2, EFNA1, FSTL1, GDF15, GFPT1, GRN, HLA-B, HOXA5, HOXC6, HSPA5, IDO1, IER3, IFIH1, IFNB1, IGFBP3,
                                                                                                      IGFBP6, IL18, IL29, ITGB1, ITM2B, LAMP2, LGALS3BP, MAP3K4, MEF2D, PLA2G16, PMEPA1, PTRH2, RALB, RBM4B, SFRS5, SH3KBP1, SIAH1, SNAI2, STAM, STX1A,
                                                                                                      TGFBR2, TGM2, TMEM107, TMEM123, TMX1, TNFSF10, TNFSF13B, TPM1, TWIST1, VAMP3, WNT5A, XBP1
                          survival            survival of cells                2.90E-03      26       CCL5, CD82, CDK5R1, CEACAM1, CXCL10, EFNA1, EHD4, GDF15, HOXA5, HSPA5, IFNB1, IGFBP3, IL18, IL29, ITGB1, MAP3K4, NT5C3, OGT, RALB, SNAI2, TGFBR2,
                                                                                                      TGM2, TNFSF10, TNFSF13B, TWIST1, XBP1
Hematological System      proliferation       proliferation of lymphocytes     3.65E-04      20       CEACAM1, E2F2, EFNA1, GABPB2, HLA-E, HSP90B1, HSPA5, IDO1, IFNB1, IL18, IL29, IL4I1, ISG20, ITGB1, NT5E, STAM, TGFBR2, TLR3, TNFSF10, TNFSF13B

Development and           accumulation        accumulation of granulocytes 1.49E-04           7       CCL5, CXCL10, GRN, IL18, ITGB1, TLR3, TNFSF10
Function
Immune Cell Trafficking   cell movement       cell movement of phagocytes 1.04E-02           10       ADM, CASP1, CCL5, CXCL10, IFNB1, IL18, ITGB1, LIPA, TGFBR2, TLR3


                          migration           migration of mononuclear         6.23E-03      11       CCL5, CEACAM1, CXCL10, CXCL16, IFNB1, IL18, IL18BP, ITGB1, NT5E, TGM2, TNFSF13B

                                              leukocytes
Tissue Development        developmental       developmental process of         2.74E-03      26       CDK5R1, CEACAM1, CXCL10, DIO2, DLL1, FOXC1, GAS1, HOXA5, HSP90B1, ITGB1, LFNG, LGMN, LIPA, MAP3K4, MEF2D, OSR1, RSAD2, SFRS5, SNAI2, TAGLN,
                                                                                                      TGFBR2, TPM1, TWIST1, WNT5A, ZFAND5, ZIC2
                          process             tissue
                          development         development of tissue            1.03E-02      21       CDK5R1, CXCL10, DLL1, FOXC1, GAS1, HOXA5, HSP90B1, ITGB1, LFNG, MAP3K4, MEF2D, OSR1, RSAD2, SFRS5, TAGLN, TGFBR2, TPM1, TWIST1, WNT5A, ZFAND5,
                                                                                                      ZIC2
Cellular Movement         invasion            invasion of cells                3.55E-04      19       ADM, CD82, CEACAM1, CXCL10, EFNA1, FSTL1, GBP1 (includes EG:2633), GDF15, GEM, GRN, IL18, ITGB1, LGMN, LOX, TAGLN, TGFBR2, TNFSF10, TWIST1, WNT5A


                          cell movement       cell movement                    1.43E-02      24       ADM, CALD1, CASP1, CCL5, CD82, CEACAM1, CXCL10, CXCL16, DLL1, E2F2, EFNA1, IFNB1, IGFBP3, IL18, IL18BP, ITGB1, LIPA, LOX, TGFBR2, TGM2, TLR3, TPM1,
                                                                                                      TWIST1, WNT5A
                          movement            movement of cells                1.40E-03      34       ABL2, ADM, AFAP1, CCL5, CD82, CDK5R1, CEACAM1, CXCL10, CXCL16, EFNA1, FOXC1, GDF15, GRN, IFNB1, IGFBP3, IGFBP6, IL18, IL29, IL18BP, ITGB1, LGMN, LOX,
                                                                                                      NT5E, RALB, SCPEP1, SNAI2, TGFBR2, TGM2, TNFSF10, TNFSF13B, TPM1, TWIST1, WARS, WNT5A
                          migration           migration of cells               2.23E-03      33       ABL2, ADM, AFAP1, CCL5, CD82, CDK5R1, CEACAM1, CXCL10, CXCL16, EFNA1, FOXC1, GRN, IFNB1, IGFBP3, IGFBP6, IL18, IL29, IL18BP, ITGB1, LGMN, LOX, NT5E,
                                                                                                      RALB, SCPEP1, SNAI2, TGFBR2, TGM2, TNFSF10, TNFSF13B, TPM1, TWIST1, WARS, WNT5A
Embryonic Development     development         development of embryo            9.01E-03      13       DLL1, E4F1, FOXC1, GAS1, ITGB1, LFNG, SNAI2, TGFBR2, TPM1, TWIST1, WNT5A, ZFAND5, ZNF830




                                             Top70 BioFunctions after overexpression of HES6 in LN405
Category                  Functions           Function Annotation              p-value    # Genes Molecules
Cellular Movement         movement            movement of cells                1.15E-16      83   ADORA1, APOE, ARHGEF4, BDKRB1, BMP6, C5ORF13, CAV1, CCL5, CCL8, CD24, CD34, CD82, CD97, CDH2, CDK5R1, CHN2, CNN1, COL1A1, COL4A1, COL4A2, CRMP1,
                                                                                                      CTGF, CTSL1, CXCL12, EDN1, ENPP2, EPHA2, ERRFI1, FOXC1, FOXO1, HEY1, HMOX1, HPSE, ID1, IGFBP2, IGFBP3, IGFBP5, IL6, IL8, IL33, ITGA3, ITGA5, JUP, KIT,
                                                                                                      LYN, MAFB, MME, MMP3, MMP9, MMP1 (includes EG:4312), NCAM1, NDN, NDP, NES, NKX2-1, NTN1, PDGFD, PDGFRA, PLAT, PLAUR, PMP22, RAC2, RAP2A, REPS2,
                                                                                                      SEMA5A, SERPINE2, SFRP4, SIRPA, SLIT2, SLPI, SNAI2, SOD2, ST8SIA2, TFPI, TGFB3, TGM2, THBS2, TIMP3, TRAF3IP2, VAV3, VCAN, VEGFA, VEGFC


                          migration           migration of cells               1.95E-16      82       ADORA1, APOE, ARHGEF4, BDKRB1, BMP6, C5ORF13, CAV1, CCL5, CCL8, CD24, CD34, CD82, CD97, CDH2, CDK5R1, CHN2, COL1A1, COL4A1, COL4A2, CRMP1, CTGF,
                                                                                                      CTSL1, CXCL12, EDN1, ENPP2, EPHA2, ERRFI1, FOXC1, FOXO1, HEY1, HMOX1, HPSE, ID1, IGFBP2, IGFBP3, IGFBP5, IL6, IL8, IL33, ITGA3, ITGA5, JUP, KIT, LYN,
                                                                                                      MAFB, MME, MMP3, MMP9, MMP1 (includes EG:4312), NCAM1, NDN, NDP, NES, NKX2-1, NTN1, PDGFD, PDGFRA, PLAT, PLAUR, PMP22, RAC2, RAP2A, REPS2, SEMA5A,
                                                                                                      SERPINE2, SFRP4, SIRPA, SLIT2, SLPI, SNAI2, SOD2, ST8SIA2, TFPI, TGFB3, TGM2, THBS2, TIMP3, TRAF3IP2, VAV3, VCAN, VEGFA, VEGFC


                          migration           migration of endothelial cells   1.45E-11      24       APOE, BDKRB1, BMP6, CAV1, COL4A1, COL4A2, CXCL12, HEY1, HPSE, ID1, IGFBP3, IL8, ITGA3, ITGA5, NDP, PDGFRA, PLAUR, SEMA5A, SFRP4, SLIT2, TGFB3, VAV3,
                                                                                                      VEGFA, VEGFC
                          migration           migration of tumor cell lines    5.90E-11      34       ARHGEF4, BDKRB1, C5ORF13, CAV1, CCL5, CD24, CD82, CD97, CDH2, CHN2, CRMP1, CTSL1, CXCL12, EDN1, ENPP2, EPHA2, ID1, IGFBP2, IGFBP3, IGFBP5, IL6, IL8,
                                                                                                      ITGA5, MME, MMP3, MMP9, NES, PLAUR, SIRPA, SLIT2, SNAI2, SOD2, VEGFA, VEGFC
                          migration           migration of brain cancer cell   3.52E-10      13       C5ORF13, CD24, CDH2, CRMP1, CXCL12, ENPP2, EPHA2, IGFBP2, MMP9, PLAUR, SIRPA, VEGFA, VEGFC

                                              lines
                          migration           migration of leukocytes          5.94E-06      30       ADORA1, APOE, BDKRB1, CCL5, CCL8, CD24, CD34, COL1A1, COL4A1, CXCL12, EDN1, IL6, IL8, IL33, ITGA3, ITGA5, KIT, LYN, MMP9, NTN1, PLAUR, RAC2, SIRPA,
                                                                                                      SLIT2, SLPI, TGM2, THBS2, TIMP3, TRAF3IP2, VEGFA
                          migration           migration of neurons             2.26E-04      13       CDH2, CDK5R1, CXCL12, ERRFI1, ITGA3, MAFB, NDN, NKX2-1, NTN1, PLAT, PLAUR, SLIT2, VEGFA

                          invasion            invasion of eukaryotic cells     4.30E-12      41       BDKRB1, CAV1, CD24, CD82, CD97, CDH2, CRMP1, CTSD, CTSL1, CXCL12, EDN1, ENPP2, EPHA2, FST, FXYD5, HMOX1, HPSE, ID1, IGFBP2, IL8, IL13RA2, ITGA3,
                                                                                                      ITGA5, JUP, MMP3, MMP9, MMP1 (includes EG:4312), NES, NKX2-1, NTN1, PLAT, PLAUR, RND3, SLIT2, SOD2, TGFB3, THBS2, TIMP3, VEGFA, VEGFC, WISP1


                          invasion            invasion of cell lines           4.18E-11      36       BDKRB1, CAV1, CD24, CD82, CD97, CDH2, CRMP1, CTSD, CXCL12, EDN1, ENPP2, EPHA2, FXYD5, HMOX1, HPSE, ID1, IGFBP2, IL8, IL13RA2, ITGA3, ITGA5, JUP, MMP3,
                                                                                                      MMP9, MMP1 (includes EG:4312), NES, NKX2-1, NTN1, PLAT, PLAUR, RND3, SOD2, TIMP3, VEGFA, VEGFC, WISP1
                          invasion            invasion of endothelial cells    3.97E-07       7       EDN1, HPSE, MMP9, THBS2, TIMP3, VEGFA, VEGFC

                          invasion            invasion of brain cancer cell    5.96E-05       7       CD24, CDH2, CRMP1, HPSE, IGFBP2, MMP9, PLAUR

                                              lines
                          cell movement       cell movement                    2.83E-08      53       ADORA1, APOE, BDKRB1, BGN, CAV1, CCL5, CCL8, CD24, CD82, CD97, CDH2, COL1A1, COL4A1, CXCL12, DBN1, EDN1, ENPP2, GJB2, ID1, IGFBP3, IL6, IL8, IL33,
                                                                                                      ITGA3, ITGA5, JUP, KIT, LYN, MMP9, NTN1, PALM, PCDH10, PDGFRA, PDPN, PLAT, PLAUR, RAC2, SIRPA, SLIT2, SLPI, SOCS2, SPINT2, TGM2, THBS2, TIMP3,
                                                                                                      TNFRSF11B, TRAF3IP2, VAV3, VCAN, VEGFA, VEGFC, WISP1, WNT5B
                          cell movement       cell movement of endothelial     1.55E-06       9       CDH2, CXCL12, IGFBP3, IL8, ITGA3, ITGA5, PDGFRA, VEGFA, VEGFC

                                              cells
                          guidance            guidance of axons                7.25E-06      13       ABLIM1, C1ORF187, CDH2, CDK5R1, CXCL12, DPYSL3, FEZ2, GAS1, KIF5C, NKX2-1, NTN1, SEMA5A, SLIT2

                          homing              homing of cells                  6.59E-04      23       ADORA1, CAV1, CCL5, CCL8, CXCL12, EDN1, ENPP2, IGFBP3, IL6, IL8, ITGA3, ITGA5, KIT, LYN, MMP9, PDGFRA, PLAUR, RAC2, SIRPA, SLIT2, THBS2, VEGFA, VEGFC


Cancer                    tumorigenesis       tumorigenesis                    9.28E-16     152       ABCC3, ACSL5, ACVR2A, ADORA1, AGPAT9, AKR1C2, ALDH3A1, APOE, ASS1, ATP1A1, BCL11A, BDKRB1, BGN, BMP6, BTG2, C10ORF116, CAMK2N1, CASP7, CAV1,
                                                                                                      CCL5, CD24, CD34, CD82, CD97, CDH2, CDKN2B, CEBPB, CGB5, CNN1, COBLL1, COL1A1, COL3A1, COL4A1, COL4A2, COL6A3, CPA4, CRYAB, CSRP2, CTGF, CTSD,
                                                                                                      CTSL1, CXCL12, CXXC5, CYGB, DBN1, EDN1, EEF1A2, ENC1, ENPP2, EPAS1, EPHA2, ERRFI1, FAM20C, FOXC1, FOXO1, FRMD4A, FST, FZD7, GALNTL4, GAS1, GJB2,
                                                                                                      GLIS3, GLO1, GPM6B, GPR56, GPRC5C, GSTM3 (includes EG:2947), HEY1, HLA-DRA, HMOX1, HPSE, ID1, IGFBP2, IGFBP3, IGFBP5, IL6, IL8, IL33, IL13RA1, IL13RA2,
                                                                                                      IL7R, ITGA3, ITGA5, JUP, KCNG1, KCNK6, KIF1A, KIT, KRT17, LAMA4, LOXL1, LYN, MAFB, MBP, MECOM, MFAP5, MLPH, MME, MMP3, MMP9, MMP1 (includes EG:4312),
                                                                                                      NCAM1, NES, NKX2-1, NLGN1, OLFML3, PDGFD, PDGFRA, PDPN, PITX1, PLAT, PLAUR, PLCE1, PRSS12, PTGR1, RAB11FIP1, RAGE, RAP2A, RBP1, RBP4, SEMA5A,
                                                                                                      SERPINE2, SFRP4, SGK1, SLC16A3, SLC7A3, SLIT2, SLPI, SNAI2, SOCS2, SOD2, SORBS2, SOX11, SPINT2, STEAP3, TFPI, TGFB3, THBS2, TIMP3, TM4SF1,
                                                                                                      TNFRSF11B, TPM2, TUBB4, UPP1, VAV3, VCAN, VEGFA, VEGFC, WISP1, WLS, WNT2, WNT5B


                          glioma              glioma                           1.65E-07      16       CAV1, CDKN2B, CYGB, ENC1, EPHA2, IGFBP2, IL6, IL13RA1, IL13RA2, KIT, MMP9, NES, PDGFRA, PDPN, SOX11, VEGFA

                          glioblastoma        glioblastoma multiforme          1.12E-06      10       CAV1, EPHA2, IGFBP2, KIT, MMP9, NES, PDGFRA, PDPN, SOX11, VEGFA

                          multiforme
                          brain cancer        brain cancer                     2.07E-06      19       BTG2, CAV1, CDKN2B, CYGB, ENC1, EPHA2, IGFBP2, IL6, IL13RA1, IL13RA2, KIT, MMP9, NES, PDGFRA, PDPN, SLIT2, SOX11, TUBB4, VEGFA

                          metastasis          metastasis                       4.97E-05      20       APOE, CAV1, CD24, CDH2, CNN1, ENPP2, EPHA2, HMOX1, IL6, KIT, MMP3, MMP9, MMP1 (includes EG:4312), NCAM1, PDGFRA, PLAUR, TUBB4, VEGFA, VEGFC, WISP1
    12/17/2011C:\Docstoc\Working\pdf\0a48c953-2dd9-481f-9a7f-478e7e2376be.xlsFunctions

Gastrointestinal Disease   colorectal cancer   colorectal cancer               4.62E-13   60    ABCC3, ACSL5, ACVR2A, AKR1C2, C10ORF116, CAMK2N1, CAV1, CD24, CD34, CDH2, COBLL1, COL3A1, COL4A1, COL4A2, COL6A3, CPA4, CTGF, CTSL1, CXCL12,
                                                                                                ENC1, ENPP2, EPAS1, ERRFI1, FST, FZD7, HLA-DRA, HMOX1, IGFBP3, IGFBP5, IL6, IL8, KIT, MAFB, MLPH, MME, MMP3, MMP9, OLFML3, PDGFRA, PDPN, PLAT,
                                                                                                PLAUR, PRSS12, RAGE, SERPINE2, SGK1, SLC16A3, SLIT2, SOD2, STEAP3, TFPI, TGFB3, TIMP3, TM4SF1, TNFRSF11B, TUBB4, VEGFA, VEGFC, WISP1, WLS


Neurological Disease       neurological        neurological disorder           1.99E-12   168   ABLIM1, ABLIM3, ACVR2A, ADORA1, AKR1C2, ANO4, AP1S2, APOE, ATL1, ATP1A1, BBOX1, BCYRN1, BDKRB1, BGN, BMP6, BTG2, C14ORF132, C5ORF13, C7ORF57,
                                                                                                CASP7, CAV1, CBS, CCDC3, CCL5, CD24, CDH2, CDK5R1, CDKN2B, CHN2, CLDN10, CNN1, CNTN1, COL1A1, COL4A1, COL4A2, COL6A3, CPVL, CRMP1, CRYAB, CSRP2,
                           disorder                                                             CTGF, CTSD, CXCL12, CYFIP2 (includes EG:26999), CYGB, CYP26B1, DAAM2, DHRS3, DIO2, DOCK10, DPYSL3, EDN1, EEF1A2, ENC1, ENPP2, EPAS1, EPHA2, FAM133A,
                                                                                                FLOT1, FOXC1, FOXN3, FOXO1, FRMD4A, GALNTL4, GJB2, GLDC, GLIS3, GLO1, GNAL, GPAM, GPC4, GPR56, GPRC5C, GRB10, HLA-DRA, HMOX1, IGFBP2, IGFBP3,
                                                                                                IGFBP5, IGFN1, IL6, IL8, IL13RA1, IL13RA2, IL7R, IVNS1ABP, KIF1A, KIT, KRT17, LDB2, LEPREL1, LMCD1, LOXL1, LRRC20, LSAMP, LYN, MBP, MECOM, MLLT11, MME,
                                                                                                MMP9, MMP1 (includes EG:4312), NCAM1, NDN, NDP, NES, NKX2-1, NLGN1, NLGN4X, NTN1, PDE9A, PDGFD, PDGFRA, PDPN, PHLDB2, PITPNC1, PLAT, PLAUR, PLCB1,
                                                                                                PLEKHG1, PMP22, PPP1R14C, PRSS12, PTPLA, RAB40B, RAP1GAP2, RASD2, RASL12, RBP4, REPS2, RIMS3, SAMD5, SCD5, SEMA5A, SERPINE2, SGK1, SLC12A2,
                                                                                                SLC16A2, SLC25A4, SLC27A1, SLC2A8, SLC35F1, SLCO4A1, SLIT2, SOD2, SORBS2, SOX3, SOX11, ST3GAL1, ST8SIA2, STAG3L1, STX1A, TGM2, TH, TIMP3, TMEM2,
                                                                                                TMEM35, TMEM47, TNFRSF11B, TRAF3IP2, TUBB4, TUBB2B, VAT1L, VAV3, VCAN, VEGFA, WLS, ZIC2

                           glioma              glioma                          1.65E-07   16    CAV1, CDKN2B, CYGB, ENC1, EPHA2, IGFBP2, IL6, IL13RA1, IL13RA2, KIT, MMP9, NES, PDGFRA, PDPN, SOX11, VEGFA

                           glioblastoma        glioblastoma multiforme         1.12E-06   10    CAV1, EPHA2, IGFBP2, KIT, MMP9, NES, PDGFRA, PDPN, SOX11, VEGFA

                           multiforme
                           brain cancer        brain cancer                    2.07E-06   19    BTG2, CAV1, CDKN2B, CYGB, ENC1, EPHA2, IGFBP2, IL6, IL13RA1, IL13RA2, KIT, MMP9, NES, PDGFRA, PDPN, SLIT2, SOX11, TUBB4, VEGFA

                           Alzheimer's         Alzheimer's disease             3.07E-06   47    APOE, ATP1A1, BCYRN1, BGN, C14ORF132, CASP7, CAV1, CBS, CDK5R1, CNN1, COL4A1, COL4A2, CSRP2, CTGF, CTSD, CXCL12, HLA-DRA, HMOX1, IGFBP2, IGFBP3,
                                                                                                IL6, IL8, LEPREL1, LRRC20, LSAMP, MECOM, MME, MMP1 (includes EG:4312), PDE9A, PDGFD, PITPNC1, PLAT, PLCB1, PLEKHG1, PPP1R14C, RAP1GAP2, SEMA5A,
                           disease                                                              SERPINE2, SOD2, SORBS2, ST3GAL1, TGM2, TIMP3, TMEM2, TNFRSF11B, TUBB4, VAT1L
                           neuropathy          neuropathy                      6.71E-05   55    ACVR2A, ADORA1, AKR1C2, AP1S2, APOE, BBOX1, BGN, C14ORF132, C7ORF57, CAV1, CCDC3, CD24, CLDN10, COL4A1, COL4A2, COL6A3, CPVL, CRYAB, DHRS3,
                                                                                                FAM133A, FLOT1, FRMD4A, GLIS3, GPC4, GRB10, HLA-DRA, IGFN1, IL6, IL7R, MBP, MMP9, NLGN1, NLGN4X, NTN1, PDE9A, PHLDB2, PLCB1, PMP22, PPP1R14C,
                                                                                                RAB40B, RAP1GAP2, REPS2, SAMD5, SEMA5A, SLCO4A1, SOD2, SORBS2, TGM2, TH, TMEM2, TMEM35, TUBB2B, VAV3, VCAN, VEGFA
Cell-To-Cell Signaling and adhesion            adhesion of cells               1.33E-11   55    ADORA1, APOE, ARHGEF4, BDKRB1, BGN, CAMK2N1, CCL5, CD24, CD34, CD82, CD97, CDCP1, CDH2, CDK5R1, CLDN10, CTGF, CXCL12, CYFIP2 (includes EG:26999),
                                                                                                EDN1, EPAS1, EPHA2, FXYD5, GPR56, HPSE, IL6, IL8, IL33, ITGA3, ITGA5, JUP, KIT, LYN, MME, NCAM1, NINJ1, PCDH10, PDPN, PHLDA1, PLAUR, RAC2, RAP2A, RND3,
Interaction                                                                                     SEMA5A, SIRPA, SLIT2, TFPI, TGM2, THBS2, TIMP3, TMOD1, TNFRSF11B, VAV3, VCAN, VEGFA, VEGFC
                           binding             binding of cell lines           2.27E-06   22    APOE, BGN, CAV1, CD24, CD34, CD82, CDC42EP1, CXCL12, ESM1, HPSE, IGFBP3, IL6, IL8, IL13RA1, ITGA3, ITGA5, KIT, LYN, PLAUR, RAMP1, TFPI, VEGFA

                           stimulation         stimulation of eukaryotic cells 1.32E-05   15    ADORA1, CCL5, CD24, CD82, CDH2, EDN1, EPHA2, IGFBP3, IL6, IL8, MBP, MSTN, NCAM1, PDGFD, VEGFA


                           activation          activation of cell lines        1.32E-06   14    ACSL5, CEBPB, CXCL12, EDN1, ID1, IL8, ITGA5, KIT, MBP, MMP1 (includes EG:4312), PLAUR, RAMP1, TGM2, VEGFA

                           signaling           signaling of cells              1.10E-04   20    ADORA1, CCL5, CCL8, CD24, CD97, EDN1, GJB2, GPR56, GRB10, IL6, ITGA3, MME, NDP, NMUR2, SEMA5A, SIRPA, TGFB3, WISP1, WNT2, WNT5B

Tissue Development         adhesion            adhesion of cells               1.33E-11   55    ADORA1, APOE, ARHGEF4, BDKRB1, BGN, CAMK2N1, CCL5, CD24, CD34, CD82, CD97, CDCP1, CDH2, CDK5R1, CLDN10, CTGF, CXCL12, CYFIP2 (includes EG:26999),
                                                                                                EDN1, EPAS1, EPHA2, FXYD5, GPR56, HPSE, IL6, IL8, IL33, ITGA3, ITGA5, JUP, KIT, LYN, MME, NCAM1, NINJ1, PCDH10, PDPN, PHLDA1, PLAUR, RAC2, RAP2A, RND3,
                                                                                                SEMA5A, SIRPA, SLIT2, TFPI, TGM2, THBS2, TIMP3, TMOD1, TNFRSF11B, VAV3, VCAN, VEGFA, VEGFC
                           aggregation         aggregation of cells            4.00E-09   25    CCL5, CD24, CD63, CDH2, CDK5R1, CXCL12, IL6, ITGA3, ITGA5, LYN, MMP3, MMP9, MMP1 (includes EG:4312), NCAM1, NTN1, PCDH10, PDPN, PLAT, PLCB1, SIRPA,
                                                                                                SLIT2, THBS2, TRAF3IP2, VAV3, WNT2
                           development         development of tissue           7.58E-07   43    ACVR2A, BMP6, CAV1, CDK5R1, COL11A1, COL6A3, CRYAB, CXCL12, EDN1, ENPP2, EPHA2, FOXC1, FOXO1, FRAS1, GAS1, GJB2, HEY1, IGFBP5, IL6, ITGA3, ITGA5,
                                                                                                KRT17, LAMA4, MECOM, MMP9, MSTN, NKX2-1, NKX2-2, NTN1, PDGFRA, PITX1, PLAT, RBP4, SLIT2, TGFB3, THBS2, TIMP3, TMOD1, TNFRSF11B, VAMP5, VEGFA,
                                                                                                VEGFC, ZIC2
                           developmental       developmental process of        1.14E-06   48    ACVR2A, BGN, BMP6, CAV1, CDK5R1, COL11A1, COL6A3, CRYAB, CXCL12, DIO2, EDN1, ENPP2, EPHA2, FOXC1, FOXO1, FRAS1, GAS1, GJB2, HEY1, HMOX1, IGFBP5,
                                                                                                IL6, ITGA3, ITGA5, KRT17, LAMA4, MECOM, MMP9, MSTN, NKX2-1, NKX2-2, NTN1, PDGFRA, PITX1, PLAT, RAC2, RBP4, SLIT2, SNAI2, TGFB3, THBS2, TIMP3, TMOD1,
                           process             tissue                                           TNFRSF11B, VAMP5, VEGFA, VEGFC, ZIC2
                           accumulation        accumulation of phagocytes 3.79E-06        11    APOE, CBS, CCL5, EDN1, HMOX1, IL8, ITGA5, MMP3, MMP9, SLPI, VEGFA

                           accumulation        accumulation of cells       7.09E-05       18    APOE, CBS, CCL5, CD24, CXCL12, EDN1, HMOX1, IL6, IL8, IL33, ITGA5, MMP3, MMP9, PLAT, RAC2, SLPI, VEGFA, ZIC2

                           accumulation        accumulation of macrophages 5.51E-04        6    APOE, CBS, CCL5, HMOX1, MMP3, VEGFA


                           formation           formation of connective tissue 2.86E-04    10    BGN, BMP6, CTGF, EDN1, FST, IGFBP3, IGFBP5, IL6, NTN1, VEGFA


Cellular Growth and        growth              growth of cells                 3.18E-11   88    ACSL5, ACVR2A, ADORA1, BDKRB1, BMP6, BTG2, CAMK2N1, CAV1, CD24, CD63, CD82, CDCP1, CDKN2B, CEBPB, COL1A1, COL4A2, COL6A3, CRYAB, CTGF, CTSD,
                                                                                                CTSL1, CXCL12, DBN1, EDN1, ENC1, EPHA2, ERRFI1, FLOT1, FOXC1, FOXO1, FST, GAS1, GJB2, GPR56, GPRC5C, GRB10, HMOX1, ID1, IGFBP2, IGFBP3, IGFBP5, IL6,
Proliferation                                                                                   IL8, IL13RA2, IL7R, ITGA3, ITGA5, IVNS1ABP, JUP, KIT, KRT17, LYN, MECOM, MMP9, MSTN, NDN, NTN1, PALM, PDGFD, PDGFRA, PHLDA1, PLAT, PLAUR, PLCE1,
                                                                                                PMP22, SERPINE2, SFRP4, SGK1, SH2B3, SIRPA, SLC2A8, SLIT2, SMYD3, SOCS2, SOD2, SPINT2, SRGN, STEAP3, TGFB3, THBS2, TIMP3, TNFRSF19, TPM2, UPP1,
                                                                                                VCAN, VEGFA, VEGFC, WISP1

                           proliferation       proliferation of eukaryotic     5.90E-09   85    ACVR2A, AGPS, APOE, BGN, BMP6, BTG2, C5ORF13, CAV1, CCL5, CD24, CDH2, CDK5R1, CDKN2B, CEBPB, CHN2, CNN1, COL1A1, COL4A1, COL4A2, CRYAB, CTGF,
                                                                                                CXCL12, CYGB, EDN1, EPHA2, ESM1, FOXO1, FST, GAS1, HEY1, HMOX1, HPSE, ID1, IGFBP2, IGFBP3, IGFBP5, IL6, IL8, IL13RA1, IL13RA2, IL7R, ITGA3, ITGA5, JUP,
                                               cells                                            KIT, LAMA4, LYN, MBP, MECOM, MEG3 (includes EG:55384), MMP3, MMP9, MSTN, MT1A, NCAM1, NDN, NDP, PDGFD, PDGFRA, PLAT, PLAUR, PLCE1, RAC2, RBP4,
                                                                                                SERPINE2, SH2B3, SIRPA, SLC2A8, SLPI, SNAI2, SOCS2, SOD2, SPINT2, SRGN, TFPI, TGFB3, TGM2, THBS2, TIMP3, TNFRSF11B, VCAN, VEGFA, VEGFC, WISP1,
                                                                                                WNT5B

                           proliferation       proliferation of endothelial    4.19E-08   18    APOE, BMP6, CAV1, CDH2, COL4A1, COL4A2, CXCL12, EDN1, FOXO1, HEY1, HMOX1, IL6, IL8, NDP, PDGFRA, TFPI, VEGFA, VEGFC

                                               cells
Cardiovascular System      development         development of blood vessel     3.60E-10   37    APOE, CAV1, CDH2, COL1A1, COL3A1, COL4A1, COL4A2, CTGF, CXCL12, EDN1, EPAS1, EPHA2, FOXC1, FOXO1, HEY1, HMOX1, HPSE, ID1, IL6, IL8, IL13RA2, LAMA4,
                                                                                                MMP3, MMP9, MMP1 (includes EG:4312), NTN1, PLAT, PLAUR, SEMA5A, SOX18, TGM2, THBS2, TIMP3, TM4SF1, TMOD1, VEGFA, VEGFC
Development and
Function                   proliferation       proliferation of endothelial    4.19E-08   18    APOE, BMP6, CAV1, CDH2, COL4A1, COL4A2, CXCL12, EDN1, FOXO1, HEY1, HMOX1, IL6, IL8, NDP, PDGFRA, TFPI, VEGFA, VEGFC

                                               cells
                           angiogenesis        angiogenesis                    5.51E-08   29    APOE, CAV1, COL4A1, COL4A2, CTGF, CXCL12, EDN1, EPAS1, EPHA2, FOXC1, HMOX1, HPSE, ID1, IL6, IL8, MMP3, MMP9, MMP1 (includes EG:4312), NTN1, PLAT,
                                                                                                PLAUR, SEMA5A, SOX18, TGM2, THBS2, TIMP3, TM4SF1, VEGFA, VEGFC
                           cell movement      cell movement of endothelial     1.55E-06    9    CDH2, CXCL12, IGFBP3, IL8, ITGA3, ITGA5, PDGFRA, VEGFA, VEGFC

                                              cells
                           neovascularization neovascularization               2.21E-05   10    APOE, CXCL12, EPAS1, EPHA2, IGFBP3, MMP9, NDP, THBS2, VEGFA, VEGFC


Organismal Development development             development of blood vessel     3.60E-10   37    APOE, CAV1, CDH2, COL1A1, COL3A1, COL4A1, COL4A2, CTGF, CXCL12, EDN1, EPAS1, EPHA2, FOXC1, FOXO1, HEY1, HMOX1, HPSE, ID1, IL6, IL8, IL13RA2, LAMA4,
                                                                                                MMP3, MMP9, MMP1 (includes EG:4312), NTN1, PLAT, PLAUR, SEMA5A, SOX18, TGM2, THBS2, TIMP3, TM4SF1, TMOD1, VEGFA, VEGFC

                           angiogenesis        angiogenesis                    5.51E-08   29    APOE, CAV1, COL4A1, COL4A2, CTGF, CXCL12, EDN1, EPAS1, EPHA2, FOXC1, HMOX1, HPSE, ID1, IL6, IL8, MMP3, MMP9, MMP1 (includes EG:4312), NTN1, PLAT,
                                                                                                PLAUR, SEMA5A, SOX18, TGM2, THBS2, TIMP3, TM4SF1, VEGFA, VEGFC
                           angiogenesis        angiogenesis of blood vessel 6.23E-04      10    COL4A2, CXCL12, HMOX1, ID1, IL6, IL8, NTN1, THBS2, VEGFA, VEGFC


Cell Death                 apoptosis           apoptosis of eukaryotic cells   1.90E-08   83    ADORA1, ALDH3A1, APOE, ATP1A1, BGN, BMP6, BTG2, CASP7, CAV1, CCL5, CD24, CDCP1, CDH2, CDK5R1, CDKN2B, CEBPB, COL4A2, CRYAB, CTGF, CTSD, CXCL12,
                                                                                                CYB5A, CYP26B1, EDN1, EEF1A2, EPAS1, EPHA2, FBXO32, FOXO1, FST, GLIPR1, GLO1, HMOX1, ID1, IFI6, IGFBP3, IGFBP5, IL6, IL8, IL7R, ITGA5, JUP, KIT, LAMA4,
                                                                                                LYN, MAFB, MECOM, MME, MMP3, MMP9, MT1A, NCAM1, NDN, NTN1, PDGFRA, PHLDA1, PLAT, PLAUR, PLCE1, RAC2, REPS2, RND3, RPS6KA2, SERPINE2, SFRP4,
                                                                                                SGK1, SIRPA, SNAI2, SOD2, ST3GAL1, STX1A, TGFB3, TGM2, THBS2, TIMP3, TNFRSF19, TNFRSF11B, TRAF3IP2, UBD, VCAN, VEGFA, VEGFC, WNT2


                           apoptosis           apoptosis                       4.20E-08   95    ADORA1, ALDH3A1, APOE, ATP1A1, BDKRB1, BGN, BMP6, BTG2, CASP7, CAV1, CCL5, CD24, CDCP1, CDH2, CDK5R1, CDKN2B, CEBPB, COL4A2, CRYAB, CTGF, CTSD,
                                                                                                CXCL12, CYB5A, CYFIP2 (includes EG:26999), CYP26B1, EDN1, EEF1A2, EPAS1, EPHA2, FBXO32, FOXO1, FST, GAS1, GLIPR1, GLO1, HEY1, HMOX1, ID1, IFI6, IGFBP3,
                                                                                                IGFBP5, IL6, IL8, IL7R, ITGA5, JUP, KIT, LAMA4, LYN, MAFB, MECOM, MME, MMP3, MMP9, MMP1 (includes EG:4312), MT1A, NCAM1, NDN, NKX2-1, NTN1, PDGFRA,
                                                                                                PHLDA1, PLAT, PLAUR, PLCE1, RAC2, REPS2, RND3, RPS6KA2, SERPINE2, SFRP4, SGK1, SIRPA, SLC25A4, SNAI2, SOD2, SORBS2, SRGN, ST3GAL1, ST8SIA2,
                                                                                                STEAP3, STX1A, TGFB3, TGM2, THBS2, TIMP3, TNFRSF19, TNFRSF11B, TRAF3IP2, UBD, VCAN, VEGFA, VEGFC, WISP1, WNT2


                           cell death          cell death                      2.79E-07   105   ADORA1, ALDH3A1, APOE, ATP1A1, BDKRB1, BGN, BMP6, BTG2, CASP7, CAV1, CBS, CCL5, CD24, CD82, CDCP1, CDH2, CDK5R1, CDKN2B, CEBPB, COL4A2, CRYAB,
                                                                                                CTGF, CTSD, CXCL12, CYB5A, CYFIP2 (includes EG:26999), CYP26B1, DPYSL3, EDN1, EEF1A2, EPAS1, EPHA2, FBXO32, FOXO1, FST, GAS1, GJB2, GLIPR1, GLO1,
                                                                                                HEY1, HMOX1, ID1, IFI6, IGFBP2, IGFBP3, IGFBP5, IL6, IL8, IL7R, ITGA5, IVNS1ABP, JUP, KIF1A, KIT, LAMA4, LYN, MAFB, MBP, MECOM, MME, MMP3, MMP9, MMP1
                                                                                                (includes EG:4312), MT1A, NCAM1, NDN, NKX2-1, NTN1, PDGFRA, PHLDA1, PLAT, PLAUR, PLCE1, PMP22, RAC2, REPS2, RND3, RPS6KA2, SERPINE2, SFRP4, SGK1,
                                                                                                SIRPA, SLC12A2, SLC25A4, SNAI2, SOD2, SORBS2, SRGN, ST3GAL1, ST8SIA2, STEAP3, STX1A, TGFB3, TGM2, THBS2, TIMP3, TNFRSF19, TNFRSF11B, TRAF3IP2,
                                                                                                UBD, VCAN, VEGFA, VEGFC, WISP1, WNT2

                           survival            survival of cells               5.57E-04   40    ABCC3, ACVR2A, ADORA1, APOE, CAMK2N1, CASP7, CAV1, CCL5, CD82, CDK5R1, CEBPB, CXCL12, EHD4, FOXO1, HMOX1, IGFBP3, IGFBP5, IL6, IL8, IL33, ITGA5,
                                                                                                JUP, KIF1A, KIT, LYN, MMP9, NTN1, PLAUR, PTGR1, RAC2, RBP1, SGK1, SNAI2, SOD2, TGFB3, TGM2, TMEM158, TRAF3IP2, VEGFA, VEGFC
Cellular Development       differentiation     differentiation of cells        2.57E-08   73    ACVR2A, ADORA1, BCL11A, BMP6, BTG2, C5ORF13, CCL5, CD24, CD82, CDK5R1, CDKN2B, CDO1, CEBPB, COL4A1, CTGF, CXCL12, CYP26B1, EDN1, ENC1, EPAS1,
                                                                                                EPHA2, FAM20C, FOXC1, FOXO1, FST, GAS1, GLIS3, HES6, ID1, IGFBP3, IGFBP5, IL6, IL8, IL33, IL13RA1, IL13RA2, IL7R, ITGA5, KIT, LAMA4, LYN, MAFB, MBP, MECOM,
                                                                                                MLPH, MMP3, MMP9, MMP1 (includes EG:4312), MSTN, NCAM1, NDN, NKX2-1, NKX2-2, NLGN1, PLAUR, PLCB1, PMP22, SFRP4, SH2B3, SOCS2, SOD2, SOX3, ST8SIA2,
                                                                                                TGFB3, TGM2, THBS2, TIMP3, TNFRSF11B, VCAN, VEGFA, VEGFC, WNT5B, ZIC2

                           developmental       developmental process of        3.37E-04   21    BTG2, C5ORF13, CD24, CEBPB, CXCL12, EPHA2, HEY1, IL6, MAFB, NCAM1, NDN, NKX2-1, NKX2-2, NLGN1, PLAT, PMP22, SLIT2, SOCS2, SOD2, TGFB3, THBS2

                           process             neurons
                           growth              growth of tumor cell lines      3.05E-06   39    ACSL5, ACVR2A, BDKRB1, BMP6, BTG2, CAMK2N1, CAV1, CDCP1, CDKN2B, COL4A2, COL6A3, CTGF, CTSD, CXCL12, EDN1, ENC1, EPHA2, FOXC1, FOXO1, FST,
                                                                                                HMOX1, ID1, IGFBP2, IGFBP3, IGFBP5, IL6, IL8, ITGA5, JUP, NDN, PLAUR, SFRP4, SOD2, STEAP3, TGFB3, TIMP3, VEGFA, VEGFC, WISP1
                           morphogenesis       morphogenesis of cells          3.13E-06   30    ARHGEF4, CCL5, CCL8, CD24, CD82, CDK5R1, COL1A1, CXCL12, EPHA2, ID1, IL6, IL8, IL7R, ITGA3, ITGA5, LYN, MMP9, NKX2-1, PDPN, PLAUR, RAC2, RND3, SIRPA,
                                                                                                SNAI2, SOD2, THBS2, VANGL2, VAV3, VEGFA, VEGFC
                           development         development of cells            4.41E-06   61    APOE, ARHGEF4, BCL11A, BPGM, CASP7, CCL5, CCL8, CD24, CD82, CDK5R1, CEBPB, COL11A1, COL1A1, CRIP2, CTSD, CXCL12, EDN1, EPAS1, EPHA2, FOXC1,
                                                                                                FOXO1, FST, HEY1, ID1, IL6, IL8, IL33, IL13RA2, IL7R, ITGA3, ITGA5, KIT, LYN, MAFB, MBP, MMP9, NCAM1, NDN, NKX2-1, NKX2-2, PDPN, PITX1, PLAT, PLAUR, PMP22,
                                                                                                RAC2, RND3, SH2B3, SIRPA, SNAI2, SOD2, ST3GAL1, TGM2, TH, THBS2, TNFRSF11B, VANGL2, VAV3, VCAN, VEGFA, VEGFC
                           epithelial-         epithelial-mesenchymal          5.96E-05    7    CAV1, FOXO1, ID1, NKX2-1, PLAUR, SNAI2, TGFB3

                           mesenchymal         transition of cells
                           transition
                           cell spreading      cell spreading of eukaryotic  4.92E-04     13    CD24, CXCL12, EPHA2, IL8, ITGA3, ITGA5, LYN, MMP9, SIRPA, SNAI2, THBS2, VAV3, VEGFA

                                               cells
Nervous System             neurological        neurological process of axons 1.07E-07     17    ABLIM1, C1ORF187, CDH2, CDK5R1, CXCL12, DPYSL3, FEZ2, GAS1, KIF5C, MBP, NCAM1, NDN, NKX2-1, NTN1, PMP22, SEMA5A, SLIT2

Development and            process
Function                   outgrowth           outgrowth of neurites           2.30E-06   23    APOE, BMP6, CDH2, CDK5R1, CXCL12, EPHA2, IL6, ITGA3, KIT, NCAM1, NDN, NINJ1, NTN1, PLAT, SEMA5A, SERPINE2, SLIT2, SOCS2, TGM2, TNFRSF19, VAV3, VCAN,
                                                                                                VEGFA
                           neurogenesis        neurogenesis                    2.55E-06   30    ADORA1, CD24, CDH2, CDK5R1, CRMP1, CXCL12, DPYSL3, ENC1, EPHA2, FEZ2, FOXO1, HES6, HEY1, ID1, IGFBP5, LSAMP, NCAM1, NDP, NES, NINJ1, NKX2-1, NKX2-2,
                                                                                                NTN1, SEMA5A, SGK1, SLIT2, SOX11, ST8SIA2, VEGFA, ZIC2
                           migration           migration of neurons            2.26E-04   13    CDH2, CDK5R1, CXCL12, ERRFI1, ITGA3, MAFB, NDN, NKX2-1, NTN1, PLAT, PLAUR, SLIT2, VEGFA

Cell Morphology            shape change        shape change                    1.78E-07   35    AP1S2, APOE, ARHGEF4, CCL5, CCL8, CD24, CDC42EP1, CDK5R1, CXCL12, EPHA2, FST, HMOX1, IL6, IL8, ITGA3, ITGA5, LYN, MMP9, NCAM1, NTN1, PALM, PLAT,
                                                                                                PLAUR, PMP22, RAP2A, RND3, SIRPA, SLIT2, SNAI2, SOD2, THBS2, VANGL2, VAV3, VEGFA, VEGFC
                           outgrowth           outgrowth of neurites           2.30E-06   23    APOE, BMP6, CDH2, CDK5R1, CXCL12, EPHA2, IL6, ITGA3, KIT, NCAM1, NDN, NINJ1, NTN1, PLAT, SEMA5A, SERPINE2, SLIT2, SOCS2, TGM2, TNFRSF19, VAV3, VCAN,
                                                                                                VEGFA
Immune Cell Trafficking    cell movement       cell movement of monocytes      3.05E-06   13    APOE, CCL5, CCL8, COL1A1, COL4A1, CXCL12, IL6, IL8, MMP9, PLAUR, SIRPA, TIMP3, VEGFA


                           cell movement       cell movement of leukocytes     2.09E-05   29    ADORA1, APOE, BDKRB1, CCL5, CCL8, COL1A1, COL4A1, CXCL12, EDN1, GJB2, IL6, IL8, IL33, ITGA3, KIT, LYN, MMP9, PLAT, PLAUR, RAC2, SIRPA, SLIT2, SLPI, TGM2,
                                                                                                THBS2, TIMP3, TNFRSF11B, TRAF3IP2, VEGFA

				
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posted:12/17/2011
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