Resveratrol and Alcohol
By Paul Mascali
Need
Resveratrol
• Resveratrol is a chemical
that is found in plants
• Resveratrol activates the
protein kinase and sirituin 1
which redistributes fat in
the liver
Alcohol
• A drug found through
the fermentation of
fruits
• Alcohol diactivates
he genes protein
kinase and sirtuin 1
the same genes that
resveratrol activates
Alcohol related diseases
• Diseases that are
effected through fat
accumulation in the
liver are cirrhosis and
fibrosis of the liver
Cirrhosis of the liver
Cirrhosis of the liver
Healthy liver fibrosis of the liver
Drosophila related to Resveratrol and Alcohol
• Drosophila when exposed to
resveratrol have found a longer
lifespan
• Drosophila when exposed to
alcohol have found a shorter
lifespan and have demonstrated
different behavioral changes
C. Elegans related to Resveratrol and Alcohol
• C. Elegans when
exposed to Resveratrol
have showed a longer
lifespan
• C. Elegans that are
exposed to Alcohol
have demonstrated
slower reaction times
Resveratrol on lifespan in Drosophila and C. Elegans
• Bass, 2007
• Resveratrol was inserted
in the drosophila food at
1, 3.2, 10, 32, 100, 200,
and 1000 mM
• Resveratrol was dissolved
at a 1:1000 to molten agar
NGM ratio during
preparation of plates for
C. Elegans
Resveratrol Life Span results
Drosophila showed no
increase to the life span
C. Elegans demonstrated a
slightly longer lifespan
when exposed to
resveratrol
Results of resveratrol on C. Elegans
Do-ability
Exposure to Resveratrol
Exposure to Alcohol