DMS ALUMNI NEWSLETTER
                                                                                                              Volume 7, Number 1
Letter from the Chairman                                                                                           January 2008
Dear DMS Alums,

I want to thank all those who      meetings with alums to talk
responded to our email             about career goals and life
requesting a brief bio to add      decisions. I hope you will
to our new website. Over           enjoy interacting with our
400 of you filled out the infor-   students and I want to
mation form and returned it.       thank those who volunteer
More update emails come in         for this program. Stay tuned
all the time. As our alums         for other activities we are
move into broader career           planning with the BGSO.
opportunities the ability to
network within our growing     Finally, most of you were             Unveiling of Portrait of Dr. Harold Amos (story pg. 2).
family becomes increasingly    predocs and many were                 Pictured from left: Chester Pierce, Stephen Coit, and
                               postdocs at HMS. You will             Allen Counter. Photo by Liza Green, HMS Media Services
                               be happy to learn there is a
Another development this       new "Postdoctoral Associa-         New website features:
year is the linking of the DMS tion" at HMS as well. Your         DMS Alumni/ae Class Notes Page
alumni committee with the      alumni committee has               Alumni’s post-DMS experiences are shared.
Biomedical Graduate Student played a role in fostering  
Organization (BGSO; bgso.      the development of a post-         DMSAlumniClassNotes.html The BGSO doctoral organization and
                                                                  DMS Alumni/ae Network Page
represents over 600 PhD        will continue to help where
                                                                  Current pursuits of alumni are listed and sorted by gradua-
students enrolled in HMS-      we can. The Postdoctoral           tion year, degree program, location, and the year they en-
based graduate programs        Association leadership             tered their program.
affiliated with the Graduate   meets with us on a regular
School of Arts and Sciences. basis. You will likely have
Their "goal is to foster com-  an opportunity to interact         If you would like your information included on these pages,
munication between the         with postdocs in the future.       send us an email at
student body and the aca-
                                                                  Inside this issue:
demic administrations." They It is a real thrill to have
also organize social or aca-   graduate students, post-           Unveiling of Portrait of Dr. Harold Amos                 2
demic activities open to all   docs and alumni all getting        New President of Harvard and Dean of Medical School      2
DMS students. The BGSO has together to share experi-              New Immunology building dedicated                        3
launched a "BGSO Student-      ences, ideas, hopes and
                               history. We have you to            New program: Human Biology and Translational Medicine    3
Alumni Lunch Program"
wherein they hope to organ-    thank for making this              Alumna Author Brings Focus to Alzheimer’s                4

ize and foster student and     possible.                          Save the date: Postdoctoral Association Reception        5
alumni networking. The DMS                                        Calling All Alumni/ae!                                   6
                                   Best regards,
students are very interested                                      BGSO-Alumni Lunch Program                                6
                                   Dennis Vaccaro
in having one-on-one
                                   PhD, Physiology ‘77            2006-2007 Graduates                                      7-11
DMS Alumni Newsletter January 2008
Unveiling of Portrait of Harold Amos, Ph.D.
    On October 4, 2007, in a ceremony at the Harvard         started with a $100,000 gift to the Harvard Foundation
Medical School Quad, the Harvard Foundation unveiled         from then president Lawrence Summers. The project
a portrait of the late Dr. Harold Amos, the first African    aims to visibly recognize minority faculty of renown and
American to chair a department at HMS, and the first         place their portraits in locations where they will be seen
African-American to receive his Ph.D. from DMS (1952).       by students.
Amos, the Maude and Lillian Presley Professor Emeritus           Present at the ceremony were several members of
of Microbiology and Molecular Genetics, passed away in       Harold Amos’s family, DMS and HMS faculty and
2003 at the age of 84 after a career at the School that      alumni, and other friends. Speakers included Amos’s
spanned nearly 50 years. In addition to twice chairing       brother, Dr. Howard Amos; Dr. Thomas Roberts, faculty
the Division of Medical Sciences and the Department of       dean for graduate education and chair of DMS; Dr. John
Microbiology and Molecular Genetics, Amos was a              Mekalanos, chair of microbiology and molecular medi-
popular teacher and mentor of both graduate and medi-        cine; Dr. S. James Adelstein, Cabot distinguished
cal students. He was instrumental in helping to organize     professor of medical biophysics and former executive
the DMS Alumni Association and was Chairman of the           dean for academic programs; Dr. Jocelyn Spragg (’69),
committee until his passing.                                 faculty director of diversity programs for DMS;
    The framed, oil-on-canvas portrait, painted by Har-      Dr. Augustus White III, professor of medical education;
vard alumnus Stephen Coit, ’72, will make its perma-         and Dr. S. Allen Counter, director of the Harvard
nent home near the Courtyard entrance to the Armenise        Foundation.
Building (formerly known as Building D). The Amos
portrait is part of the Minority Portraiture Project,           Article contributed to by Dr. Jocelyn Spragg, (’69).

New Harvard President and Dean of HMS
    Drew Gilpin Faust has been named the 28th presi-            A member of the HMS faculty since 1978, Flier has
dent of Harvard University. The first Dean of the           served for the past five years as chief academic officer
Radcliffe Institute for Advanced Study and the Lincoln      at BID, where he also is faculty dean for academic
Professor of History at Harvard, Faust took over the        programs. He has been closely involved in discussions
position from interim president Derek Bok on July 1,        on the future of Harvard-wide science as a founding
2007. She is Harvard’s first female president. Presi-       member of the Harvard University Science and Engineer-
dent Faust was formally installed on October 12 during      ing Committee and, previously, through his service on
an outdoor ceremony in Tercentenary Theatre at the          the University Planning Committee for Science and
Cambridge campus.                                           Engineering.
    On July 11, President Faust announced that Jeffrey          For further information on President Faust or Dean
Flier, the George C. Reisman Professor of Medicine at       Flier, please visit the Harvard University and Harvard
HMS and Beth Israel Deaconess Medical Center, has           Medical School websites.
been appointed the new dean of the Faculty of
Medicine, effective September 1.                            Portions taken with permission from the February 23 and July
                                                            13 Harvard FOCUS.

Page 2
                                                     DMS Alumni Newsletter January 2008
New Immunology building
     On November 17, 2007, the Jeffrey Modell Immunol-
ogy Center at Harvard Medical School was dedicated.
The new building, located within the Armenise Building’s
former courtyard space, will be home for the DMS Immu-
nology Ph.D. Program.
    The Center was built as a collaboration between Har-
vard Medical School and the Jeffrey Modell Foundation
(JMF). JMF seeks to promote research, treatment, and
ultimately cures of Primary Immunodeficiency diseases.
They have research programs and diagnostic centers
across the globe.
    According to the JMF website, the Center will serve
“as a focal point for the most dynamic and diverse
community of immunologists in the world.” The building
holds new facilities for teaching, seminars, study areas,
and as well as new office space for Immunology
administration and faculty.

New BBS Program: Human Biology and Translational Medicine
     In Fall 2008, DMS will usher in a new program un-      program, this partnership provides the chance to study
der the auspices of Biological and Biomedical Sciences      human disease states and to identify improved means
(BBS). According to the BBS website, the new Human          for preventing, diagnosing and treating diseases.
Biology and Translational Medicine (HBTM) program will           The HBTM curriculum, built upon four new courses,
combine “the understanding of the basic scientific          will center on providing training in the “fundamental
mechanisms of human biology and disease with its            mechanisms and essential methodologies of human
translation into clinical medicine.” Partnered with the     biology and disease-oriented translational research.”
new Leder Medical Sciences Program of Harvard Inte-         Instruction will include developing and analyzing human
grated Life Sciences (HILS), the HBTM program will          trials in order to identify new approaches to diagnosing
utilize and expand upon work already being done at          and treating diseases.
Harvard and Harvard-affiliated institutions.
     The Leder Program offers HILS students the
opportunity to take additional courses in pathology,           For more information about this program,
pathophysiology and pharmacology, and to acquire            please visit the BBS HBTM website at
some clinical experience. For those within the HBTM

                                                                                                            Page 3
DMS Alumni Newsletter January 2008
“Still Alice”: An Alumna Looks at Alzheimer’s
     “What is having Alzheimer’s disease like from the point      amyloid plaques and/or neurofibrillary tangles in the
of view of the person with Alzheimer’s?” This is the ques-        brain, caused Alzheimer’s. But it has been found that
tion Lisa Genova (Ph.D., Neuroscience, 1998) asks and             cellular loss is often not visible on MRIs, especially for
explores in her new novel, “Still Alice.” In her book,            those in the early stages of this disease. And
Genova tells the story of Alice, a fifty year old professor at    “cognitive deficits-the symptoms of dementia-occur
Harvard who develops early-onset Alzheimer’s. Faced with          before the plaques form, before the neurons die.” A
the grim reality of soon losing the things that had previ-        new thinking has therefore emerged, which focuses
ously defined her, Alice begins to examine how she will           on the synapses in the brain.
now assess and validate her life in the face of living with           In an Alzheimer’s patient, when there is too much
this disease.                                                     of the soluble protein Amyloid Beta 42 in the synapse,
     "I shadowed neurologists at Massachusetts General            “individual peptides stick together and form small
Hospital and Brigham and Women's Hospital in Boston. I            oligomers.” These oligomers in the synapses in turn
talked to research scientists, general practice physicians,       prevent good neurotransmission between neurons.
genetic counselors, and social workers. And I emailed with        Over time, this malfunctioning (along with other prob-
people living with early-onset dementia daily for over a          lems) causes the neurons to die, which is the atrophy
year," says Genova. "Alice is fictional, but I felt a very real   seen on MRIs. The disease seems to begin then with
responsibility to show her diagnosis, treatment, and symp-        the break down in the synapses. “The degree of
tom progression as truthfully as possible."                       dementia,” remarks Genova, “correlates only with
     Part of that responsibility comes as a result of her fam-    synapse dysfunction, not with neuronal loss, not with
ily’s own experience. While at DMS, a lab down the hall           number of plaques, not with atrophy on an MRI.”
working on Alzheimer’s sparked an interest for Genova,                In her blog, Genova lists four treatment possibili-
but it was not until her own grandmother was diagnosed            ties that are shaped by this new discovery. These
with the disease that she really began to be drawn to the         prospects are focused on treatment being able to
study of this illness. Watching aspects of her grandmother        “impede production of Amyloid Beta 42, to increase
slowly fade away, she began to wonder what it was like for        clearance of already-produced Amyloid Beta 42, to
her to start to have, as Genova puts it, “those parts of the      prevent Amyloid Beta 42 from sticking to itself so it
brain that inform awareness and identity become increas-          cannot form oligomers, or to rip these already-formed
ingly inaccessible.”                                              oligomers apart.” Many of the current clinical trials
     Through her book, she hopes to not only raise aware-         focusing on this protein, like those of Myriad and Elan
ness of the stigmas and barriers faced by those living with       Pharmaceuticals, are still in phase I or II of their
Alzheimer’s, but also to have people realize the specific         studies, though.
challenges faced by those living with the early-onset of this         Still, “the beauty and the hope in all of these treat-
disease. “The general public knows what the eighty-five-          ments,” writes Genova, “[is that] people suffering
year-old grandparent in end stages of the disease looks           from symptoms of dementia can be treated before
and sounds like,” says Genova, “but they have little idea         they’ve experienced any neuron death. If the syn-
what the fifty-year old parent with Alzheimer's looks and         apses are fixed, neurotransmission can work again.
sounds like. It's time this group had a face and a voice."        Function can be restored!”
     Genova has partnered with the National Alzheimer’s
Association and their VOICE OPEN MOVE campaign, which                 For more information on Alzheimer’s and the VOICE
seeks to provide resources for patients and caregivers as         OPEN MOVE campaign, please visit the Alzheimer’s Asso-
well as to treat and eventually eliminate Alzheimer’s dis-        ciation online at
                                                                      For more information on Genova and her book, please
ease through continued developments in research.
     One new development is a change in thinking about
the possible cause of Alzheimer’s. It has been customarily
                                                                     Quotes taken from “Still Alice” press release and
thought that neuronal death, due to the build up of
                                                                  Genova’s blog for the VOICE OPEN MOVE campaign.
Page 4
                                                    DMS Alumni Newsletter January 2008

      Postdoctoral Association Reception
    On Thursday, March 20th at 7 pm, the PDA will be
         sponsoring a reception on the Quad for                         Save the Date!
                 alumni and postdocs.
                                                                        PDA Reception
      Alumni, come out and share your expertise and
              experiences with these fellows!                           March 20, 2008
  For more information, visit our Alumni Events & News

Notes from the HMS PDA
    The Harvard Medical School and Harvard School of       local community
Dental Medicine Postdoctoral Association (HMS/HSDM        • Postdoc Lecture Tour to China in 2007: International
PDA) is a member run, non-profit organization repre-       career opportunity for Chinese postdocs
senting the postdoctoral fellows at Harvard Medical
School, Harvard School of Dental Medicine and all         • Postdoctoral   Newsletter: Weekly event calendar
their affiliated institutions.                             distributed to 3,000 Harvard Postdoctoral Fellows
    Currently, the HMS PDA, which was founded more           Many of these events were attended by more than
than 4 years ago, has over 800 subscribed members         300 people and were deemed a tremendous success.
and can reach over 3,000 postdocs at Harvard Medi-            As postdocs are an extremely neglected population
cal School and HMS-affiliated institutions.               within the Harvard academic community – in terms of
    The goals of the HMS PDA are to provide represen-     finances as well as mentoring, we feel that postdocs
tation to the Harvard postdocs and to act as a liaison    should get much more attention and support.
between all affiliated postdoctoral fellows within the        Currently, one of our most important goals is to
Harvard medical community. Therefore, our associa-        increase our visibility and membership. To achieve this
tion aims to address postdoctoral policies, support       goal, we build up a modern internet platform that does
career development of postdocs and coordinate social      not only offer postdocs valuable information concerning
events to enhance the networking among all postdocs       careers etc. but also tools to connect all postdocs and
at Harvard. As the biomedical industry plays a key role   faculty members across the medical campus. Why
concerning postdoctoral career development, we also       shouldn’t a postdoc who needs help with a specific
dedicate ourselves to connecting Harvard postdocs         technique have the chance to find and address a post-
with the local industrial/business community.             doc who is expert and just working next door?
   During our brief existence the HMS Postdoctoral           If you would like to support us with your advice or
Association has organized various events, including:      make a financial contribution to sponsor our events or
• Symposia    and    Panel     Discussions:      Large,   the construction of our new website, please don’t
 multi-speaker events on specific topics of interest      hesitate to address us via email or phone.
• Career Development Services: Career          related       If you are a postdoc and are interested in joining the
 workshops and online job postings                        HMS PDA, just go on our website at
• Postdoc Lunches: Opportunities for postdocs to meet
 Harvard faculty to share knowledge                       In the name of the HMS PDA Board,
• Social Networking Events: Opportunities for the post-   Emre Basar (Co-Chair) and Haixin Lei (Co-Chair)
 doctoral community to network
                                                ; 617-959-6916
• Walk for Hunger: Charity event to bridge the PDA and; 617-880-9076
                                                                                                            Page 5
DMS Alumni Newsletter January 2008

Calling All Alumni/ae!
                     Just started a new job? Recently been promoted?
  Send us your new contact information, and we’ll post it online and/or in the next newsletter.

    Have an idea for a story? Want to share about the exciting research taking place in your
   lab? Did you find a career you never knew existed or thought would be possible with your
                            degree? Tell us, and we’ll write about it!

           Would you like to participate in our monthly Alumni Committee meetings?
                     Send us an email, and we’ll reserve parking for you.

BGSO-Alumni Lunch Program
         We’ve recently launched a collaboration with current DMS graduate students,
                               and we want you to play a part!

  This new program allows for current students to take an alumnus/a out to lunch on campus
                  (we pay) to discuss careers, life after DMS—you name it.

                  Interested in helping to answer current students questions?
           Want to let them know of a career option of which not many people know?

                    Send us an email, and we’ll put you on the list of alumni
                             wanting to be contacted by students!

                                        DMS Alumni Office
                                     Harvard Medical School
                                260 Longwood Avenue, TMEC 435
                                        Boston, MA 02115
                                      phone: 617.432.3372
                                        fax: 617.432.2644
Page 6
                                                           DMS Alumni Newsletter January 2008
2006-2007 Graduates
Sarah Bael Anderson
Ph.D., Cell and Developmental Biology

                                                                                                                     Photo by Mark Bogacz
Advisor: Dr. Malcolm Whitman
Post-Translational Regulation of TGF-Š Superfamily Ligands in
Skeletal Muscle and During Xenopus Embryogenesis
Sean Andre Beausoleil
Ph.D., Cell and Developmental Biology
Advisor: Dr. Steve Gygi                                          Assembly
Large-scale Analysis of Protein Phosphorylation
                                                                 Catarina deHaseth Campbell
Isaac Bernstein-Hanley                                           Ph.D., Genetics
Ph.D., Genetics                                                  Advisor: Dr. Joel Hirschhorn
Advisor: Dr. William Dietrich                                    Implications of population structure and regulatory variation
Genetic analysis of susceptibility to Chlamydia trachomatis in   for genetic association studies
                                                               Betty Chan
Jay Benjamin Bikoff                                            Ph.D., Biological Chemistry and Molecular Pharmacology
Ph.D., Neuroscience                                            Advisor: Dr. Tom Ellenberger
Advisor: Dr. Michael Greenberg                                 Functional Studies of the Calcineurin-DSCR1 Complex
Molecular mechanisms regulating cortical development: From
                                                               Wendy Chao
neurons to synapses
                                                               Ph.D., Genetics
Brenda L. Bloodgood                                            Advisor: Dr. Patricia D'Amore
Ph.D., Neuroscience                                            IGF2: Epigenetic Regulation and Role in Development and
Advisor: Dr. Bernardo Sabatini                                 Disease
Biochemical Compartmentalization and Synaptic Signaling in
                                                               Adrienne Chen
                                                               Ph.D., Virology
Jesse Samuel Boehm                                             Advisor: Dr. Frederick Wang
Ph.D., Pathology                                               Epstein-Barr Virus Nuclear Antigen 3B- and 3C-regulated cellu-
Advisor: Dr. William C. Hahn                                   lar genes in virus-immortalized B cells
Experimental models of transformation as platforms for onco-
                                                               Yoojin Choi
gene discovery
                                                               Ph.D., Neuroscience
Roberto Bonasio                                                Advisor: Dr. Rosalind A. Segal
Ph.D., Immunology                                              Mitogenic Niches in the Developing Cerebellum
Advisor: Dr. Ulrich von Andrian
                                                               Eunju Chung
Migration and Function of Circulating Dendritic Cells
                                                               Ph.D., Neuroscience
Eric David Boyden                                              Advisor: Dr. Thomas Schwarz
Ph.D., Genetics                                                Axonal Transport of Synaptic Components and Synaptogenesis
Advisor: Dr. William Dietrich                                  in Drosophila
Identification and characterization of a novel gene that con-
                                                               David Ciccone
trols mouse macrophage susceptibility to anthrax lethal toxin
                                                               Ph.D., Immunology
Kevin Francis Bryant                                           Advisor: Dr. Marjorie Oettinger
Ph.D., Virology                                                The epigenetic regulation of V(D)J recombination: chromatin
Advisor: Dr. Donald Coen                                       architecture and the insulator protein, CTCF
Regulation of Translation During Herpes Simplex Virus-1 Infec-
                                                               Banumathi Kuppusami Cole
                                                               Ph.D., Pathology
Matthew Edwin Call                                             Advisor: Dr. Andrea I. McClatchey
Ph.D., Immunology                                              Membrane Distribution of the Nf2 Tumor Suppressor, Merlin
Advisor: Dr. Kai Wucherpfennig
Intramembrane Organization of T Cell Receptor-CD3 Complex
                                                                                                                                            Page 7
DMS Alumni Newsletter January 2008
2006-2007 Graduates
                                                                    Adam Amiel Laufer Friedman
Serafin Colmenares                                                  M.D./Ph.D., Genetics
Ph.D., Cell and Developmental Biology                               Advisor: Dr. Norbert Perrimon
Advisor: Dr. Danesh Moazed                                          Genomic dissection of receptor tyrosine kinase activation of
The Mechanism of RNAi Assembly and siRNA Generation in              extracellular signal-regulated kinase in Drosophila
Fission Yeast Centromeres
                                                                    Seth Eric Frietze
Can Cui                                                             Ph.D., Biological Chemistry and Molecular Pharmacology
Ph.D., Biological Chemistry and Molecular Pharmacology              Advisor: Dr. Pamela Silver
Advisor: Dr. Donald Coen                                            Genome-wide analysis of the coactivator-associated arginine
Herpes Simplex Virus DNA Replication and MicroRNA Expres-           methyltransferase CARM1 in breast cancer cells
sion: Molecular Pharmacological, Computational, and Genetic
Approaches                                                          Elizabeth Eve Glater
                                                                    Ph.D., Neuroscience
Savita Visalakshi Dandapani                                         Advisor: Dr. Thomas Schwarz
M.D./Ph.D., Genetics                                                The Mechanism for Axonal Transport of Mitochondria in Droso-
Advisor: Dr. Martin Pollak                                          phila
Role of alpha-actinin-4 in the kidney
                                                                    Carson Alexis Goddard
Christopher Anthony Dimitri                                         Ph.D., Neuroscience
Ph.D., Cell and Developmental Biology                               Advisor: Dr. Carla Shatz
Advisor: Dr. John Blenis                                            MHC Class I and the Homeostatic Regulation of CNS Synapses
Analysis of the Ras-MAPK Pathway: Spatially Separate Docking
Sites on ERK2 Regulate Distinct Signaling Events and Biologi-       Seth R. Goldman
cal Processes                                                       Ph.D., Microbiology and Molecular Genetics
                                                                    Advisor: Dr. Marcia Goldberg
Krista Carol Dobi                                                   The role of the shf operon in the biology of Shigella flexneri
Ph.D., Genetics
Advisor: Dr. Fred Winston                                           John Richard Greenland
Upstream Activation Sequence Function in Saccharomyces              M.D./Ph.D., Virology
cerevisiae: the Potential for Long Distance Transcriptional Acti-   Advisor: Dr. Norman Letvin
vation and the Role of Sin4                                         Vaccine antigen expression and immune responses

Rebecca Lynn Dunfee                                                 Brian Palmer Hafler
Ph.D., Virology                                                     Ph.D., Neuroscience
Advisor: Dr. Dana Gabuzda                                           Advisor: Dr. David H. Rowitch
Envelope-receptor Interactions of Neurotropic HIV                   Transcriptional Regulation of Olig2 in Motor Neuron Develop-
Patrick Allen Everley
Ph.D., Cell and Developmental Biology                               John William Hanna
Advisor: Dr. Bruce Zetter                                           M.D./Ph.D., Cell and Developmental Biology
The development of quantitative and functional proteomic            Advisor: Dr. Daniel Finley
technologies and their application to the study of prostate can-    Functional Analysis of Ubp6, a Proteasome-Associated Deubiq-
cer                                                                 uitinating Enzyme

Anna Flora Farago                                                   Dana Brooke Harrar
M.D./Ph.D., Genetics                                                Ph.D., Neuroscience
Advisor: Dr. Susan Dymecki                                          Advisor: Dr. Michael Greenberg
Uncovering molecular and spatial predictors of brainstem neu-       An RNA Interference Screen Identifies New Molecules Re-
ron identity                                                        quired for Mammalian Synapse Development

Christine Marie Field                                               Matthew Robert Hass
Ph.D., Cell and Developmental Biology                               Ph.D., Neuroscience
Advisor: Dr. Marc Kirschner                                         Advisor: Dr. Bruce Yankner
Genetic and Biochemical Studies of Cytokinesis                      Identification of Novel Roles of the Amyloid Precursor Protein
                                                                    in Signal Transduction
 Page 8
                                                                              DMS Alumni Newsletter January 2008
2006-2007 Graduates
                                                                                Advisor: Dr. Hidde Ploegh
Xi He                                                                           Identification and Characterization of a Novel Deubiquitinating
Ph.D., Virology                                                                 Activity Conserved Within the Herpesvirus Large Tegument
Advisor: Dr. Robert Kingston                                                    Proteins
Regulation of SNF2h Chromatin Remodeling Activity
                                                                                Christine Mei Lian Khoo
Bryan McIver Hooks                                                              Ph.D., Genetics
Ph.D., Neuroscience                                                             Advisor: Dr. Ronald DePinho
Advisor: Dr. Chinfei Chen                                                       Adaptive Responses of Oncogenic Cells to Dysfunctional Te-
Functional Development of the Retinogeniculate Synapse                          lomeres
Franklin Huang                                                                  Eirene Kontopoulos
Ph.D., Genetics                                                                 Ph.D., Neuroscience
Advisor: Dr. Nancy Andrews                                                      Advisor: Dr. Mel Feany
The role of hemojuvelin in systemic iron homeostasis                            Mechanisms of alpha-synuclein Neurotoxicity in Parkinson's
Damon Richard Neppl Huber                                                       Disease
Ph.D., Microbiology and Molecular Genetics                                      Sergei B. Koralov
Advisor: Dr. Jonathan Beckwith                                                  Ph.D., Immunology
A Genetic Analysis of Protein Folding and Protein Translocation                 Advisor: Dr. Klaus Rajewsky
in Escherichia coli                                                             Role of Secondary IgH Rearrangements in B Cell Ab Repertoire
Michael Evan Hughes                                                             Jennifer Rose Kowalski
Ph.D., Neuroscience                                                             Ph.D., Cell and Developmental Biology
Advisor: Dr. Dietmar Schmucker                                                  Advisor: Dr. Sheila Thomas
A Genetic and Biochemical Analysis of Dscam Signaling in                        Regulation of Normal and Malignant Cellular Processes by the
Dendrite Morphogenesis                                                          Cytoskeletal Scaffold, Cortactin
Nina Lu Hunter                                                                  Magda Maria Latorre-Esteves
Ph.D., Genetics                                                                 Ph.D., Microbiology and Molecular Genetics
Advisor: Dr. Susan Dymecki                                                      Advisor: Dr. David Sinclair
Redefining the dorsal hindbrain based on genetic lineage                        Characterization of the Saccharomyces cerevisiae sirtuin fam-
Justin Kawika Ichida                                                            ily and their roles in lifespan regulation
Ph.D., Genetics                                                                 Anne Margaret Lee
Advisor: Dr. Jack W. Szostak                                                    Ph.D., Genetics
In Vitro Selection Systems for TNA                                              Advisor: Dr. Chao-ting Wu
Alexander Choi Jackson                                                          Trans interactions at the yellow gene in Drosophila
Ph.D., Neuroscience                                                             melanogaster
Advisor: Dr. Bruce Bean                                                         Kyriacos C. Leptos
Subthreshold Currents Underlying the Spontaneous Firing of                      Ph.D., Genetics
Hypothalamic Pacemaker Neurons                                                  Advisor: Dr. George Church
Lisa Marie Kattenhorn                                                           Computational Tools for Peptide Quantification Using Mass
Ph.D., Virology                                                                 Spectrometry and Their Application to the Proteome of Pro-
                                                                                chlorococcus marinus MED4
                                                                                Juying Li
                                                                                Ph.D., Cell and Developmental Biology
                                                                                Advisor: Dr. Junying Yuan
                                                                                Characterization of the Role of Caspase-11 in Regulating Actin
                                                       Photo by Mark Bogacz

                                                                                Dynamics and Cell Migration
                                                                                Jamie H. Lichtenstein
                                                                                Ph.D., Biological Sciences in Public Health

                                                                                                                                       Page 9
DMS Alumni Newsletter January 2008
2006-2007 Graduates                                                          Herpes Simplex Virus Inhibition of Innate Type-I Interferon In-
                                                                             Robin Kate Meray
                                                                             Ph.D., Biological Chemistry and Molecular Pharmacology
                                                                             Advisor: Dr. Peter Lansbury

                                                      Photo by Mark Bogacz
                                                                             Biochemical and cell biological studies of the Parkinson's dis-
                                                                             ease-associated ubiquitin hydrolase UCH-L1
                                                                             Miriam Elizabeth Osterfield
                                                                             Ph.D., Cell and Developmental Biology
                                                                             Advisor: Dr. John Flanagan
                                                                             Identification and characterization of binding partners for a
Advisor: Dr. Joseph Brain                                                    cell surface receptor in chick brain development
Mouse Strain Differences Influence Pulmonary Responses to
Stachybotrys chartarum                                                       Yong-Ling Patricia Ow
                                                                             Ph.D., Immunology
Malen Amanda Link                                                            Advisor: Dr. Stuart Schreiber
Ph.D., Virology                                                              Investigating the metabolism of tumours with an in silico
Advisor: Dr. Priscilla Schaffer                                              chemical genetics approach
Mechanism of expression and functional analysis of herpes
simplex virus type-1 proteins OBPC-1 and OBPC-2                              Noëlle Nicole Paffett-Lugassy
                                                                             Ph.D., Genetics
Kwa Yu Liou                                                                  Advisor: Dr. Leonard Zon
Ph.D., Pathology                                                             Hematopoiesis and angiogenesis in the zebrafish
Advisor: Dr. Peter Howley
A chemical genetic screen to identify small molecule inhibitors Kathleen Lindahl Pfaff
of HPVE6-mediated p53 degradation                               Ph.D., Genetics
                                                                Advisor: Dr. Leonard Zon
Michael John Malecki                                            Genetic analysis of the cell cycle and cancer in zebrafish
Ph.D., Biological Chemistry and Molecular Pharmacology
Advisor: Dr. Stephen Blacklow                                   Andrew Davidson Redd
The Notch Negative Regulatory Region: Mutations and Mecha- Ph.D., Virology
nisms                                                           Advisor: Dr. Max Essex
                                                                Human Immunodeficiency Virus Type 1 Subtype C and Hema-
Laura Leigh Marcotte                                            topoiesis
Ph.D., Biological Chemistry and Molecular Pharmacology
Advisor: Dr. James M. Hogle                                     José Rivera-Feliciano
Structural and biochemical studies of the poliovirus precursor Ph.D., Genetics
protein 3CD and the components of the viral replication com- Advisor: Dr. Clifford Tabin
plex                                                            Genetic regulation of heart-valve development

Adam Goon Wai Matthews                                          Nadia Rui-Zhen Roan
Ph.D., Immunology                                               Ph.D., Microbiology and Molecular Genetics
Advisor: Dr. Marjorie Oettinger                                 Advisor: Dr. Michael Starnbach
Regulatory mechanisms in V(D)J recombination                    Antigen-specific T cell responses to Chlamydia trachomatis

Jason Marcus McEwen                                                          Lindsay Merritt Rohas
Ph.D., Genetics                                                              Ph.D., Cell and Developmental Biology
Advisor: Dr. Josh Kaplan                                                     Advisor: Dr. Bruce M. Spiegelman
Trafficking of Synaptic Proteins and Tomosyn inhibits Synaptic               A Fundamental System of Cellular Energy Homeostasis Regu-
Vesicle Priming                                                              lated by PGC-1a

Gregory Taylor Melroe                                                        Patrick Safo
Ph.D., Virology                                                              M.D./Ph.D., Neuroscience
Advisor: Dr. David Knipe                                                     Advisor: Dr. Wade G. Regehr
                                                                             The role of endocannabinoids in synaptic plasticity at the gran-
Page 10                                                                      ule cell to Purkinje cell synapse
                                                              DMS Alumni Newsletter January 2008
2006-2007 Graduates                                                 The Role of Forkhead Transcription Factors in Hematopoiesis
Noel Joy Sauer                                                      and Leukemogenesis
Ph.D., Microbiology and Molecular Genetics
Advisor: Dr. Marcia Goldberg                                        Cecily Kennedy Vanderspurt
Shigella Activation of the Actin Assembly Switch Protein N-         Ph.D., Microbiology and Molecular Genetics
WASP                                                                Advisor: Dr. Stephen Calderwood
                                                                    Post-Transcriptional Control of Cholera Toxin and Factors Af-
Marc Adam Schwabish                                                 fecting the Virulence of V. cholerae
Ph.D., Biological Chemistry and Molecular Pharmacology
Advisor: Dr. Kevin Struhl                                           Emily Suzanne Venanzi
Asf1 and Swi/Snf Function in RNA Polymerase II Elongation           Ph.D., Immunology
and Histone Dynamics                                                Advisors: Dr. Christophe Benoist & Dr. Diane Mathis
                                                                    Mechanisms of aire control of immunological tolerance
Elizabeth Shakhnovich
Ph.D., Microbiology and Molecular Genetics                          Sarah Rebecca Walker
Advisor: Dr. John Mekalanos                                         Ph.D., Cell and Developmental Biology
Small molecules as novel probes for understanding Vibrio            Advisor: Dr. David Frank
cholerae virulence mechanisms and regulation in vitro and in        Opposing Roles of STAT5 and STAT3 on Gene Regulation and
vivo                                                                Cancer

Aimee Shen                                                          Jamie Evan Wong
Ph.D., Microbiology and Molecular Genetics                          Ph.D., Immunology
Advisor: Dr. Darren Higgins                                         Advisors: Dr. Christophe Benoist & Dr. Diane Mathis
Transcriptional repression, anti-repression, and glycosylation      The life of the regulatory T cell repertoire
in the regulation of flagellar motility in Listeria monocytogenes   Diedra M. Wrighting
Amanda Marie Simons                                                 Ph.D., Genetics
Ph.D., Pathology                                                    Advisor: Dr. Nancy Andrews
Advisor: Dr. Jeffrey Parvin                                         Transcriptional Regulation of Hepcidin, a hormone that main-
Biochemical Functions of BRCA1 Protein Complexes                    tains ironhomeostasis

Donald William Smith                                                Na Xu
Ph.D., Microbiology and Molecular Genetics                          Ph.D., Genetics
Advisor: Dr. Cathryn Nagler                                         Advisor: Dr. Jeannie T. Lee
The role of innate immune signaling in generating tolerance         The Mechanism of Homologous Interaction at the X-
and immunity to orally administered antigens                        Inactivation Center

Leta Suzanne Steffen                                                Annie Yang
Ph.D., Genetics                                                     Ph.D., Biological Chemistry and Molecular Pharmacology
Advisor: Dr. Louis M. Kunkel                                        Advisor: Dr. Kevin Struhl
Zebrafish as a Model of Muscular Dystrophies and Insights           Transcriptional Targets and Functional Activities of the p53
into Titin's Role in Sarcomerogenesis                               Gene Family

Elizabeth Harmon Stover                                             Glenn Chung-Wing Yiu
M.D./Ph.D., Genetics                                                M.D./Ph.D., Neuroscience
Advisor: Dr. D. Gary Gilliland                                      Advisor: Dr. Zhigang He
FIP1L1-PDGFRalpha, a tyrosine kinase fusion protein involved        Signaling Mechanisms Limiting Axon Regeneration in the Adult
in chronic eosinophilic leukemia                                    Central Nervous System

Vesselin T. Tomov                                                   Joshua Daniel Yoder
M.D./Ph.D., Genetics                                                Ph.D., Virology
Advisor: Dr. Brian Seed                                             Advisor: Dr. Philip Dormitzer
Codon-Optimized & Reporter-Packaging Strains of HIV-1               Molecular Rearrangements of Recombinant and Authentic
                                                                    Rotavirus VP5*
Zuzana Tothova
M.D./Ph.D., Genetics
Advisor: Dr. D. Gary Gilliland
                                                                                                                          Page 11
Upcoming events:

• March 20: Postdoctoral Association Reception

• Participate in the BGSO-Alumni lunch program! See page 6 to learn how!

• April 25-27: National Postdoctoral Association’s Annual Meeting being held in
  Boston, co-hosted by the HMS PDA
• June 4-5: DMS Commencement events

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