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					- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - Hoffmann-La Roche
PRODUCT NAME: Injacom 100 B Complex AVDA MSDS NO.: MS3277 MANUFACTURER: HOFFMANN-LA ROCHE INC. ENVIRONMENTAL & SAFETY AFFAIRS NUTLEY, NEW JERSEY 07118 TELEPHONE: 201-235-2323 DATE OF MSDS: February 17, 1986 ----------------------------------------------------------SECTION I - IDENTIFICATION ----------------------------------------------------------TRADE NAME: Injacom 100 B Complex CHEMICAL NAME: 9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol CODE NO.: 24618, 24621, 29170, 63857, 65213, 65214, 65215, 65216, 65218, 65219, 65227, 65388 CAS NO.: 67-97-0 FORMULA: C27H45O FORMULATION: Vitamin D3 Pastilles SYNONYMS: Vitamin D3 resin; cholecalciferol, activated-7dehydro; irradiated 7-dehydro cholesterol. CHEMICAL FAMILY: Sterol MOLECULAR WEIGHT: 384.62 ----------------------------------------------------------SECTION II - PHYSICAL PROPERTIES ----------------------------------------------------------APPEARANCE AND ODOR: Pale amber-to-dark brown lumps SOLUBLE IN: Fat solvents, e.g., ether and alcohol. MELTING POINT: 84-85 deg C SOLUBILITY IN WATER, % BY WT. AT 20 deg C: Insoluble OPTICAL ROTATION (in acetone): +84.8 ----------------------------------------------------------SECTION III - CHEMICAL PROPERTIES ----------------------------------------------------------STABILITY: Stable CONDITIONS TO AVOID: Light, heat, moist air. MATERIALS TO AVOID: Oxidants at high temperatures; inorganic salts. HAZARDOUS POLYMERIZATION: Will not occur. ----------------------------------------------------------SECTION IV - HAZARDOUS INGREDIENTS ----------------------------------------------------------Not applicable (if code # identifies a formulated product, the non-active moiety is inert and non-toxic). ----------------------------------------------------------V - FIRE AND EXPLOSION HAZARD ----------------------------------------------------------None known EXTINGUISHING MEDIA: Water spray, dry chemical, carbon dioxide or foam, as appropriate for surrounding fire and materials. FIRE FIGHTING PROCEDURES: Evacuate personnel to an area of upwind direction and remove unneeded materials; keep fire-exposed containers cool with water spray, and provide fire fighters with self-contained breathing equipment. ----------------------------------------------------------VI - HEALTH HAZARDS ----------------------------------------------------------THRESHOLD LIMIT VALUE: TWA: None established STEL: None established TOXICITY: INDUSTRIAL EXPOSURE: Ingestion, hypervitaminosis D. EXPERIMENTAL: Because "no toxicological distinctions between vitamins D2 and D3 are recognized" [GI 76] the following data for vitamin D2 are relevant: LDLO (dog, orl): 4 mg/kg LDLO (dog, iv): 5 mg/kg LDLO (dog, ip): 10 mg/kg LDLO (dog, im): 5 mg/kg EMERGENCY AND FIRST AID: EYE CONTACT: Irrigate surfaces with water thoroughly. SKIN CONTACT: Flush areas with water thoroughly.

----------------------------------------------------------SECTION VII - SAFETY MEASURES AND EQUIPMENT ----------------------------------------------------------VENTILATION: Mechanical acceptable. RESPIRATORY: NIOSH-approved dust respirator. EYES: Safety glasses GLOVES: Neoprene OTHER DIRECTIVES: STORAGE AND HANDLING CONDITIONS: Store under refrigeration within light-resistant vessels. ----------------------------------------------------------SECTION VIII - SPILL CONTROL, WASTE TREATMENT AND DISPOSAL ----------------------------------------------------------SPILL CONTROL: Scoop up all spills and transfer to labeled containers. WASTE TREATMENT AND DISPOSAL: Recycle. ----------------------------------------------------------SECTION IX - REGULATIONS ----------------------------------------------------------DOT: Not regulated EPA: Not regulated ----------------------------------------------------------The information contained herein is, to the best of Hoffmann-La Roche's knowledge, complete and accurate. Roche, however, uses many sources and references for gathering this information. Thus, Roche cannot guarantee completeness or accuracy and disclaims all liability for its handling or use. ----------------------------------------------------------DISCLAIMER OF EXPRESSED AND IMPLIED WARRANTIES: Although reasonable care has been taken in the preparation of this document, we extend no warranties and make no representation as to the accuracy or completeness of the information contained therein, and assume no responsibility regarding the suitability of this information for the user's intended purposes or for the consequences of its use. Each individual should make a determination as to the suitability of the information for their particular purpose(s). A request has been made to the manufacturer to approve the contents of this material safety data sheet. Upon receipt a new MSDS will be made available. ----------------------------------------------------------COMPAS Code: 33300370

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