MSDS for by liaoqinmei

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                                   1. PRODUCT IDENTIFICATION
Product Name:            IN SITU CELL DEATH DETECTION KIT

Business Unit:           Molecular Biochemicals

Part Number:             N/A

Component Part No:       N/A

Catalog Number:          1684809

Preparation Date:    2/22/2000
Contact/Preparatory: Don Pearson

Information Number: 1-800-428-5074 (x2343)                    NOTE: CHEMTREC is an emergency number
Emergency Number: 1-800-424-9300 (CHEMTREC)                   to be used only in emergencies involving a
                                                              chemical accident, spill, leak, fire or exposure.

         2. COMPOSITION / INFORMATION ON HAZARDOUS INGREDIENTS

CHEMICAL NAME                   CAS #      % W/V                      EXPOSURE LIMITS IN AIR
                                                          ACGIH              OSHA                 OTHER
                                                      TLV      STEL      PEL      STEL

Reagent 1: Vials 1 & 2
Sodium Cacodylate              124-65-2     3.2%      0.01     N/A     10 ug/m3    N/A      (limit is as arsenic)
                                                     mg/m3




Reagent 2: N/A




Reagent 3: N/A
                                                                                                                    Page 2 of 6

Reagent 4: N/A




Reagent 5: N/A




Reagent 6: N/A




                                             3. HAZARD IDENTIFICATION
Primary Routes of Entry:
Inhalation, ingestion, skin and/or eye contact.



Inhalation:
Toxic if inhaled. Excessive inhalation causes irritation of stomach and intestines with
nausea, vomiting, diarrhea, shock, rapid pulse, coma.                                              NFPA Rating

Ingestion:
Toxic if swallowed. Ingestion causes irritation of stomach and intestines with
nausea, vomiting, diarrhea, shock, rapid pulse, coma.
                                                                                                       Fire
Skin Contact:
                                                                                                        0
May irritate skin.



Eye Contact:                                                                                 Health              Reactivity
May irritate eyes.                                                                             3                     1


Chronic Exposure:                                                                                     Hazard
N/A
                                                                                                      I, T, CA

Medical Conditions Aggravated by Exposure:
None



Health Effects:
Symptoms of exposure may include: fatigue, coughing, or shortness of breath.




                                                  4. FIRST AID MEASURES
Inhalation:
If breathing becomes difficult, remove victim to fresh air. Seek medical assistance immediately.
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Ingestion:
Call physician; induce vomiting giving gastric lavage and a saline cathartic. Do NOT use BAL as an antidote.



Skin Contact:
Avoid skin contact. If skin contact occurs, wash contaminated skin with water and remove contaminated clothing. Get medical
attention if the skin becomes irritated.

Eye Contact:
Flush eye(s) with large volumes of water for at least 15 minutes. Get medical attention.




                                           5. FIRE FIGHTING MEASURES
Flash Point (Method used): >200 C                        Flammable Limits-LEL: N/A                         UEL: N/A

Extinguishing Media:
Use fire extinguishing media appropriate for site conditions.

Special Fire Procedures:
Structural firefighting gear and self-contained breathing apparatus will provide adequate protection if this
product is in a fire area.
Unusual Fire and Explosion Hazards:
N/A


                                     6. ACCIDENTIAL RELEASE MEASURES
Steps to be Taken in Case Material is Released or Spilled:
Use an absorbent material to contain/pick up the spilled solution. Place all contaminated disposables into a suitable
container, seal, label and hold for disposal. Use necessary protective equipment while cleaning up spill.




                                            7. HANDLING AND STORAGE
Store at -20 C. See package insert for further storage and handling information.


                      8. EXPOSURE CONTROLS AND PERSONAL PROTECTION
Ventilation Data:
A system of general and/or local exhaust is recommended.

Respiratory Protection:
Respiratory protection is not required during normal use of this product.



Protective Gloves:
Wear appropriate protective gloves to prevent skin contact.

Other Protective Equipment:
Wear appropriate eye protection to prevent eye contact. Wear appropriate body protection to prevent
skin contact.
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Other Engineering Controls:
Eye wash stations and deluge showers.

Work Practices:
Good laboratory technique should be used when handling this product. Observe appropriate chemical
hygiene. Avoid contact with skin or eyes. Do not place in mouth.
Hygienic Practices:
Do not eat, drink, or smoke while working with product. Upon completion of work activities involving this
product, wash hands thoroughly with soap and water.


                            9. PHYSICAL AND CHEMICAL PROPERTIES
For All Components Unless Otherwise Indicated

     Relative Vapor Density (air = 1): N/A                      Evaporation Rate (nBuAc = 1): N/A
     Specific Gravity (water = 1): N/A                          Freezing/Melting Point: N/A
     Solubility in Water: Soluble in water                      Boiling Point: N/A
     Vapor Pressure, mm Hg @ 20o C: N/A                         pH: 7.5-8.5


Ordor and Apperance Information
    Reagent 1:
    Liquid, colorless, faint odor.

    Reagent 2:
    N/A

    Reagent 3:
    N/A

    Reagent 4:
    N/A


    Reagent 5:
    N/A

    Reagent 6:
    N/A




                                     10. STABILITY AND REACTIVITY
Incompatibility (Materials to Avoid):
Oxidizers. Do not store with organic peroxides or flammables.
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Hazardous Decomposition Products:
Thermal decomposition may emit toxic by-products.


Will Hazardous Polymerization Occur?
Hazardous polymerization will not occur.

Conditions to Avoid/Polymerization:
None

Is the Product Stable?
Yes, under normal handling and storage conditions.

Conditions to Avoid/Stability:
Incompatible, excess heat, flame, or pressure.



                                      11. TOXICOLOGICAL INFORMATION
Toxicity Data:
Sodium Cacodylate: LD50 (rat, oral)=2600 mg/kg. This agent may cause nephrotoxicity, hepatotoxicity, and may produce
abnormalities of the hematopoietic system.

Reproductive Effects:
N/A

Target Organ Effects:
Arsenic compounds (inorganic): skin, respiratory system, kidneys, central nervous system, liver, gastrointestinal tract, reproductive
system.


Carcinogenicity: Yes
                                                                            NTP Carcinogen
CHEMICAL NAME                           CAS #         % W/V            Known            Anticipated               IARC        OSHA
Sodium cacodylate solution            124-65-2        3.2%              Yes                 No                  Group 1         Yes



                                         12. ECOLOGICAL INFORMATION
Environmental Fate/Stability:
Sodium Cacodylate is hazardous to water and ground water. Organoarsenicals such as sodium cacodylate
are adsorbed by clay soils
Effect of Material on Plants or Animals:
N/A

Effect of Chemical on Aquatic Life:
N/A
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                                       13. DISPOSAL CONSIDERATIONS
Waste Disposal Method:
Please consult local, state and federal regulations for additional guidance on disposal.

EPA Waste Number:
D004; A solid waste containing arsenic (such as sodium cacodylate) may or may not become
characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure

                                    14. TRANSPORATION INFORMATION
Is this Material Hazardous? Yes

  Proper Shipping Name: Arsenic compound,liquid,n.o.s.
  Hazard Class Number:              6.1         Packing Group:         III             UN Number:         UN 1556



                                          15. REGULATORY INFORMATION
U.S. SARA Reporting Requirements:
100 pounds

U.S. SARA Threshold Planning Quantity:
100/10,000 pounds

U.S. CERCLA Reportable Quantity (RQ):
Sodium Cacodylate=100/10,000 pounds

U.S. TSCA Inventory Status:
Sodium Cacodylate is listed under TSCA.

Other U.S. Federal Regulations:
Full IATA/DOT shipping name: Arsenic compound,liquid,n.o.s. (Sodium cacodylate solution)



California Safe Drinking Water and Toxic Enforment Act (Proposition 65):
N/A


                                             16. OTHER INFORMATION
Other Comments:
N=No Y=Yes T=Toxic I=Irritant CA=Carcinogenic IARC Group 1: The agent (mixture) is carcinogenic to humans. The
exposure circumstance entails exposures that are carcinogenic to humans. N/A=Not applicable or no information.




                                                           DISCLAIMER
The information, data and recommendations contained herein are based upon information believed by Roche Diagnostics Corporation
("RDC"), after reasonable investigation and research, to be accurate; however, RDC does not warrant the accuracy of this information.
All materials and mixtures may present unknown hazards and should be used with caution. When necessary or appropriate,
independent opinions regarding the risk of handling or exposure should be obtained from trained professionals. RDC disclaims any
warranty against patent infringement and the implied warranties of merchantability and fitness for a particular purpose. Customer's
sole and exclusive remedy shall be replacement of the product or return of the product and refund of the purchase price, at RDC's
option. In no case shall RDC be liable for incidental or consequential damages, including lost profits.

								
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