AstraZeneca US backgrounder fact sheet

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US Fact Sheet Helping Make Healthcare Personal Again AstraZeneca is one of the world's leading healthcare and pharmaceutical companies, with US headquarters in Wilmington, Delaware. We make a broad range of meaningful medicines that have made a difference in people's lives. AstraZeneca is focused on future treatments for fighting serious and chronic diseases that are the leading causes of death and disability. We're concentrating on preventing and treating cancer, diabetes and obesity, infectious diseases, mental health illnesses and chronic respiratory diseases. Some of the key products in our broad product portfolio include CRESTOR® (rosuvastatin calcium), NEXIUM® (esomeprazole magnesium), SEROQUEL® (quetiapine fumarate) and SYMBICORT® (budesonide/formoterol fumarate dihydrate) Inhalation Aerosol. A complete portfolio list and full prescribing information for all of our medicines can be found on our Web site (http://www. astrazeneca-us.com). While we continually invest in finding new, effective prescription medications and treatments for diseases, we recognize that no matter how effective our medicines, they do little good for people who do not have access to them, cannot afford them, or cannot fully understand how to take them. At AstraZeneca, we strive to make a meaningful difference in people's lives--both inside and outside of our research laboratories. AstraZeneca at a Glance Headquarters: US: Wilmington, DE Worldwide: London, United Kingdom Employees: US: 12,000 Worldwide: 67,000 2007 Annual Sales: US: $13.35 billion Worldwide: $29.56 billion NYSE: AZN North American CEO: Tony Zook Global CEO: David Brennan Commitment to Research: 16 R&D sites worldwide; US sites in Waltham, MA and Wilmington, DE; $5 billion committed to R&D in 2007 Affordable Medicines: In the past six years, our industry-leading patient assistance programs have provided more than $3 billion in savings to people throughout the US and Puerto Rico who need help affording their medicines Giving Back: In addition, more than $47 million in contributions were donated to hundreds of US nonprofit organizations in 2007 Our Culture: 100 Best Companies to Work For, FORTUNE magazine; Best Places to Work in Industry, The Scientist; 100 Best Companies for Working Mothers, Working Mother magazine; Top 15 Fittest Companies in America, Men's Fitness magazine; Top 50 Companies for Diverse Managers, DiversityMBA Magazine; 50 Best Companies, Conceive Magazine; Best Employer for Healthy Lifestyles, National Business Group on Health Making Meaningful Medicines--and Beyond Our scientists are working every day to develop new medicines to fight diseases. Our investment in research and development increased to more than $5 billion in 2007. Globally, we doubled the number of our Phase III, or what we call largescale patient clinical trials, in our overall pipeline during 2007. We are further extending our commitment to cutting-edge research and development with a $100 million expansion of our Waltham, Massachusetts' facility to accommodate up to 100 additional researchers focused on discovering treatments for infectious diseases and cancer. Helping People Afford Medicines and Healthcare Making meaningful medicines will always be at the core of our mission, but we also recognize people confront many challenges in the search for quality healthcare. So we ask ourselves every day, what more can and should a pharmaceutical company do to improve healthcare? AstraZeneca in the Community Every day AstraZeneca is working hard to improve health in all of our communities. In 2007 alone, we contributed more than $47 million to hundreds of US nonprofit organizations. We also helped nearly half a million people fill 2.8 million prescriptions resulting in more than $500 million of savings to patients. US Fact Sheet Affordable Medicines Our AZ&Me™ Prescription Savings helps qualified patients access the AstraZeneca medicines they need and information that can help them stay healthy. In the past six years, our patient assistance programs have provided more than $3 billion in savings to patients throughout the US and Puerto Rico who need help affording their medicines. The programs also provide one-on-one education and information designed to help all individuals identify and access health and medicine coverage and services for which they may be eligible. Those who qualify for the AZ&Me™ Prescription Savings program for people without insurance can receive up to a 90-day supply of AstraZeneca medicine, free of charge, delivered directly to their home. In addition, the AZ&Me™ Prescription Savings program for people with Medicare Part D provides significant savings to qualifying people who are enrolled in Medicare Part D prescription drug coverage plans and are having difficulty affording their AstraZeneca medicines. Partnering to Prevent Disease AstraZeneca supports the American Cancer Society, and has made contributions to build two AstraZeneca Hope Lodge Centers, which will provide free temporary lodging and support services for cancer patients who must travel for outpatient treatment to Boston and Philadelphia. We also provide health education information to millions of Americans through public awareness campaigns like National Breast Cancer Awareness Month (NBCAM), the American Heart Association Start! walking program and the AstraZeneca Cancer Support Network (AZCSN), which provides free support to patients in more than 100 languages. We believe patients across the country should be afforded health tools and resources to manage conditions from prevention of a disease through wellness. We at AstraZeneca devote considerable resources to nationwide programs that meet these criteria, like the National Alliance on Mental Illness (NAMI) Connection, a mutual support program for people with mental illness available in English and Spanish. These are examples of some of the programs we carry out in communities across the United States. And we do more. Access to Quality Healthcare AstraZeneca believes everyone should have access to affordable healthcare. In our home state of Delaware, we are collaboratively partnering with dozens of organizations statewide on “Healthy Delawareans Today & Tomorrow.” This program is dedicated to help Delaware's uninsured children and families gain access to needed free or low-cost healthcare services they need to lead healthier, happier lives. Wellness with our Employees As a healthcare company dedicated to improving the lives of people all over the world, our job starts with our own employees. We're proud that AstraZeneca was among the first six companies to receive CEO Gold Standard Accreditation by the CEO Roundtable on Cancer, recognizing the ongoing actions we take to promote cancer-prevention initiatives among employees and their dependents. We were also named the first recipient of the American Heart Association's “FitFriendly Company” award, which recognizes companies that are taking a lead to support corporate wellness initiatives that encourage employees to incorporate exercise into their workday. We are one of three-dozen US employers recognized by the National Business Group on Health for our innovative efforts to battle obesity and promote a healthy work environment for our employees. In addition, AstraZeneca was recognized on FORTUNE's “100 Best Companies to Work For” list, receiving special mention for our on-site wellness programs, fitness center and other amenities available to our employees including childcare. Learn More We don't have all the answers but what we do know is how we treat people is as important as the medicines we make. We are dedicated to providing the tools, resources, support and information needed to help people live longer, healthier lives. To learn more about how AstraZeneca is improving healthcare, visit (http://www.astrazeneca-us.com). CRESTOR, NEXIUM, SEROQUEL, and SYMBICORT are registered trademarks and the AZ&Me is a trademark of the AstraZeneca group of companies. ©2008 AstraZeneca Pharmaceuticals LP. All Rights Reserved.

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