CNS Stimulants
General Precautions
• SE: headache, dizziness, apprehension,
hyperactivity, NVD, insomnia,
tachycardia
• DI: MAOI
CNS Stimulants
• CNS Stimulant – Analeptic
– Stimulate respiratory centers
• CNS Stimulant –Amphetamine
– General CNS stimulation
• CNS Stimulants - Anorexiants
– Used to suppress appetite
CNS Stimulants – Analeptics
• Actions
– Stimulate carotid and aortic oxygen receptors
• Increases depth of respiration
– Some are general CNS Stimulants
• caffeine
CNS Stimulants – Analeptics
• Uses
– Drug-induced respiratory depression
• Opioids, alcohol
– Respiratory depression due to pulmonary disease
– Post-operative to restore breathing
– Narcolepsy – excess desire to sleep
Doxapram [DOPRAM]
• Group: CNS Stimulants - Analeptics
• IND: Drug-induced respiratory depression
• SE:
• AR:
• CI:
• PC:
• DI:
CNS Stimulants –Amphetamines
• Actions
– Sympathomimetic in CNS
• Results in increased BP, pulse, wakefulness
– Stimulate appetite center in hypothalamus
Amphetamines Various & Generic
• Group: CNS Stimulants -Amphetamines
• IND: Narcolepsy, ADHD, Exogenous obesity
• SE: Insomnia, nervousness, tachycardia
• AR:
• CI:
• PC:
• DI:
CNS Stimulants –Amphetamines
• Uses
– Short-term Tx of exogenous obesity
– (excess caloric intake)
• Abuse potential limits usefulness
– Narcolepsy
– ADHD
Methylphenidate [CONCERTA, RITALIN]
• Group: CNS Stimulants –Amphetamines
• Schedule II
• IND: ADHD, Narcolepsy
• SE:
• AR:
• CI:
• PC:
• DI:
CNS Stimulants - Anorexiants
• Actions
– Stimulate appetite centers in hypothalamus
CNS Stimulants - Anorexiants
• Uses
– Short-term Tx of exogenous obesity
Phentermine Fastin
• Group: CNS Stimulants – Anorexiants
• Schedule IV
• IND: Obesity
• SE:
• AR:
• CI:
• PC:
• DI: