Author AEDs Tx Duration Bias Superiority DNIB Exit criteria Class Key Variable Pb PHT CBZ VPA GBP LTG TPM OXC VGB CZP PRM Other
Mattson (85) CBZ, PHT, PB, PRM Yes Double blind Yes 34% Clin. Response I 101 110 101 109
Chadwick (99) CBZ, VGB Yes Double blind Yes 24% Clin. Response I 226 220
Mattson (92) CBZ, VPA Yes Double blind No 23% Clin. Response II DNIB 236 244
Arroyo (-) TPM No (26) Double blind Yes 37% Forced III Exit criteria 84 + 98
Gilliam (03) TPM No (24) Double blind Yes 34% Forced III Exit criteria 103 + 113
Chadwick (98) GBP No (24) Double blind Yes 41% Forced III Exit criteria 74 + 72
Sachdeo (00) OXC No (13) Double blind Yes 59% Forced III Duration 1
Brodie (02a) CBZ, REM Yes Double blind Yes 70 % Clin. Response III DNIB ≥ 65 years 7 10 37
Author AEDs Tx Duration Bias Superiority DNIB Exit criteria Class Key Variable Pb PHT CBZ VPA GBP LTG TPM OXC VGB CZP PRM Other
Arroyo (-) TPM No (26) Double blind No 43% Forced III Exit criteria 68 + 66
Brodie (95) CBZ, LTG Yes Double blind No 45% Clin. Response III DNIB 62 60
Privitera (03) TPM, CBZ, VPA Yes Double blind No 45% Clin. Response III DNIB 29 39 123
Steiner (99) LTG, PHT Yes Double blind No 51% Clin. Response III DNIB 49 42
Bill (97) OXC, PHT Yes Double blind No 53% Clin. Response III DNIB 38 48
Christie (97) OXC, VPA Yes Double blind No 54% Clin. Response III DNIB 38 43
Dam (89) CBZ, OXC Yes Double blind No 60% Clin. Response III DNIB 32 32
Gibberd (82) PHT, PNT No (24) Double blind No 63% Forced III DNIB 1 1
Brodie (02) GBP, LTG No (30) Double blind No 76% Clin. Response III DNIB 22 18
Ramsay (83) CBZ, PHT No (26) Double blind No n/a Clin. Response III DNIB 11 11
Reunanen (96) CBZ, LTG No (30) Open Label No 32% Forced III OL 87 90 + 99
Feksi (91) CBZ, PB Yes Open Label No 40% Clin. Response III OL 75 77
Richens (94) CBZ, VPA Yes Open Label No 42% Clin. Response III OL 69 69
Ramsay (92) PHT, VPA No (26) Open Label No 47% Clin. Response III OL 44 73
Sommerfeld-Ziskin (40) PB Yes Open Label Unclear 55% Clin. Response III OL 36 42
Turnbull (85) PHT, VPA Yes Open Label No 57% Clin. Response III OL 39 37
Heller (95) CBZ, PHT, PB, VPA Yes Open Label No 57% Clin. Response III OL 33 35 37 36
Callaghan (85) CBZ, PHT, VPA Yes Open Label No 59% Clin. Response III OL 36 27 36
Rastogi (91) PHT, VPA No (24) Open Label No 60% Clin. Response III OL 31 34
Turnbull (82) PHT, VPA Yes Open Label No 66% Clin. Response III OL 28 23
Placencia (93) CBZ, PB Yes Open Label No 73% Clin. Response III OL 24 19
Shakir (81) PHT, VPA Yes Open Label No n/a Forced III OL 3 4
Kalviainen (95) CBZ, VGB Yes Open Label No n/a Forced III OL 8 11
DNIB - detectable
non-inferiority boundary
Author AEDs Tx Duration Bias Superiority DNIB Exit criteria Class Key Variable Pb PHT CBZ VPA GBP LTG TPM OXC VGB CZP PRM Other
Glauser (-) TPM No (26) Double Blind Yes 61%* Forced III Exit criteria 32 + 39
Thilothammal (96) PB, PHT, VPA Yes Double Blind No 52% Clin. Response III DNIB 43 46 38
Guerreiro (97) OXC, PHT Yes Double Blind Unclear 74% Clin. Response III DNIB 17 22
Wheless (-) TPM, CBZ, VPA Yes Double Blind No 74% Clin. Response III DNIB 5 14 29
Canadian Group (98) CBZ, CLB Yes Double Blind No n/a Clin. Response III DNIB 5 6
Feksi (91) CBZ, PB Yes Open Label No 40% Clin. Response III OL 75 77
Verity (95) CBZ, VPA Yes Open Label No 42% Clin. Response III OL 69 64
Callaghan (85) CBZ, PHT, VPA Yes Open Label No 59% Clin. Response III OL 36 27 36
Rastogi (91) PHT, VPA No (24) Open Label No 60% Clin. Response III OL 31 34
De Silva (96) CBZ, PB, PHT, VPA Yes Open Label No 66% Clin. Response III OL 5 24 25 24
Placencia (93) CBZ, PB Yes Open Label No 73% Clin. Response III OL 24 19
Sommerfeld-Ziskin (40) PB Yes Open Label Unclear 79% Clin. Response III OL 10 42
Pal (98) PB, PHT Yes Open Label No 82% Clin. Response III OL 22 12
Shakir (81) PHT, VPA Yes Open Label No n/a Forced III OL 1 2
Author AEDs Tx Duration Bias Superiority DNIB Exit criteria Class Key Variable Other PLB GBP
Rating (00) STM No (26) Double Blind Yes 59% Forced III Exit criteria 31 35
Bourgeois GBP No (26) Double Blind Yes Forced III Exit criteria
Author AEDs Tx Duration Bias Superiority DNIB Exit criteria Class Key Variable Pb PHT CBZ VPA GBP LTG TPM OXC VGB CZP PRM ETX PLB
Sato (82) ETX, VPA No Double Blind No n/a Clin. Response III Tx Duration 7 9
Trudeau (96) GBP No Double Blind No 82% Clin. Response III Tx Duration 15 18
Frank (99) LTG No Double Blind Yes 83% Clin. Response III Tx Duration 14 14
Callaghan (82) ETX, VPA Yes Open Label No 83% Clin. Response III OL 14 14
Martinovic (83) ETX, VPA Yes Open Label No n/a Clin. Response III OL 10 10
Coppola (04) LTG, VPA Yes Open Label No 79% Clin. Response III OL 19 19