SYNOPSIS
TITLE OF DISSERTATION
“A CLINICAL COMPARATIVE STUDY TO EVALUATE THE
EFFICACY OF DRAKSHAVALEHYA AND DHATRI-LOHA IN
THE MANAGEMENT OF PANDU w.s.r TO IRON DEFICIENCY
ANEMIA.”
For Degree of MD(AYU)
In
Rajiv Gandhi University Of Health Sciences
Bengaluru, Karnataka
By
Dr.MUMTAZ BEGUM. A.C BAMS
I YEAR PG MD(AYU)
GUIDE
Dr.NERUDU UMA SRINIVAS RAO MD(AYU)
Prof.Dept of PG studies in Kaya chikitsa
Ayurvedic Medical College and P.G Centre ,Davanagere.
CO GUIDE
Dr. JAYANTHI. C MD(AYU)
Prof.Dept of PG studies in Kaya chikitsa
Ayurvedic Medical College and P.G. Centre, Dvavanagere.
From,
Dr.MUMTAZ.BEGUM AC, B.A.M.S., 1st Year M.D. (Ayu.),
Department of Post Graduate Studies in Kayachikitsa,
Ayurvedic Medical College and P.G. Centre,
Davanagere – 577566
To,
The Registrar,
Rajiv Gandhi University of Health Sciences,
Bengaluru, Karnataka.
Through: The Principal and Head of Department of Post Graduate Studies in
Kayachikitsa, Ayurvedic Medical College and P.G. Centre,
Davanagere-577004.
Respected Sir/Madam,
Subject: Submission of completed Proforma for Registration of Subject for
Dissertation.
I request you to kindly register the below mentioned subject against my name
for the submission of dissertation to the Rajiv Gandhi University of Health Sciences,
Bengaluru, Karnataka for the partial fulfillment of M.D. (Ayu.)
Title of Dissertation:
“A CLINICAL COMPARATIVE STUDY TO EVALUATE THE EFFICACY
OF DRAKSHAVALEHYA AND DHATRI-LOHA IN THE MANAGEMENT
OF PANDU w.s.r TO IRON DEFICIENCY ANEMIA.”
Here with, I am enclosing the completed Proforma for Registration of subject
for dissertation.
Thanking You
Yours faithfully,
Date:
Place: Davanagere. (Dr. MUMTAZ.BEGUM.AC.)
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,
BENGALURU - KARNATAKA
ANNEXURE - II
COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT FOR
DISSERTATION
1. Name of the Candidate Dr. MUMTAZ.BEGUM.AC
and address #1528,CHAMUNDINAGAR,
NEAR SHALINI BAR
R.T.NAGAR POST
BENGALURU-560032
2. Name of Institution AYURVEDIC MEDICAL COLLEGE &
P.G. CENTRE
ASHWINI NAGAR, P.B. ROAD,
DAVANAGERE-577566
3. Course of Study AYURVEDA VACHASPATI,
M.D. (Ayurveda) IN KAYACHIKITSA
4. Date of Admission 15. 11. 2010
5. Title of Topic “A CLINICAL COMPARATIVE STUDY
TO EVALUATE THE EFFICACY OF
“DRAKSHAVALEHYA” AND “DHATRI-
LOHA” IN THE MANAGEMENT OF
PANDU w.s.r TO IRON DEFICIENCY
ANEMIA.”
6. BRIEF RESUME OF INTENDED WORK:
6.1 NEED FOR THE STUDY:
Anemia is a defined as a state in which the quality and or quantity of
circulating red blood cells are below normal1.
Anemia is a serious public health problem having a direct bearing on physical
development, immuno-competence, learning behavior and work capacity, maternal
mortality and caring capacity2.
In India, Anemia affects an estimated 50% of population. IDA is the most
wide spread form of malnutrition in the world, affecting more than 2 billion people.3
It is important to note that Anemia has multiple causes in addition to the low
in take of Iron rich foods
These include the low dietary intake of enhancers of Iron absorption, the
presence in the diet of inhibitors of Iron absorption, over cooking of food, parasitic
infestations, lack of awareness and illiteracy, low socio-economic status,& poor
hygiene4.
Therefore more research is needed on these and other factors to better
understand the underlying causes of High Anemia Levels. Thus, in order to increase
the quality of life an attempt has been made to overcome the Anemia condition, as it
is important economically because it diminishes the capability of individuals who are
affected.
6.2 REVIEW OF LITERATURE
1.NIDANA, SAMPRAPTI & LAKSHANA OF PANDU ARE EXPLAINED IN5
a) Charaka samhita – Chikitsa sthana – 16th chapter – shloka no – 4,10
page no. 591, 592.
b) Bhava Prakash – Chikitsa sthana – 8th chapter – shloka no – 1.2,
page no. 98,99,100.
c) Vanga Sen – Pandu rogadhikara – shloka no – 1 to 12.
d) Yogaratnakar – pandu rogadhikara – shloka no – 1,2,11, page no. – 339, 340.
2. THE CHIKITSA OF PANDU IS EXPLAINED IN:6
a) Charaka samhita – Chikitsa sthana – 16th chapter– shloka no– 40, 41, 42
page no. – 98, 99, 100.
b) Bhava Prakash – Chiktsa sthana – 8th chapter –shloka no– 27,28,29,
page no. 105.
c) Chakra Datta – Pandu rogadhikara– 8th chapter – shloka no – 33,34,41,42,43.
page no. – 55,56.
d) Bhaisajya Ratnavali – Pandu roga chikitsa – 12th chapter – shloka no – 29,30,
page no. – 269-270.
e) Yogaratnakara – Pandu rogadhikar – shloka no. – 1,2,3,4. page no. 339,340.
3. THE SIGN AND SYMPTOM OF I.D.A ARE EXPLAINED IN:7
a) DAVIDSON – Anemia – chapter 11 – page no – 749,757,75
b) HARRISON – Iron Deficiency Anemia – page no – 588, 589.
CLASSICAL REFERENCE OF DRAKSHAVALEHYA IS FOUND IN:8
Ashtanga hridaya Chikitsa sthana 16th chapter –Pandu roga chikitsa shloka
no. 29th ,30th ,31st Page no.446
CLASSICAL REFERENCE OF DHATRI LOHA IS FOUND IN:9
Bhaisajya Ratnavali 30th chapter .Shloka no.149,150,151.Page no.459
PREVIOUS WORK DONE10
1. Dr. Bullaih T – A clinical study of yashtimadhu in the management of Pandu
roga, Hyderabad – 1999
2. Dr. Tabake Basavaraj – A comparative study on the effect of Dhatri Avalehya
and Kaseesa Bhasma in Pandu roga w.s.r to IDA – Udupi , 2002.
3. Dr. Jain Sangeeta- A study on Pandu roga w.s.r to Anemia and its management
with shodhana and yogaraja rasayana – Jamnagar, 2000.
4. Dr. Lobo Zenica – Evaluation of the effect of Shuddha Kaseesa and loha bhasma
in Pandu roga w.s.r to IDA – A comparative study, GAMC Mysore – 2002
5. Songale Bandappa: Preparation of Lohabhasma and its clinical study on Pandu
roga w.s.r to IDA, SDM college of Ayurveda, Udupi – 2004
6. OBJECTIVES OF THE STUDY
To review the literature on IDA
To evaluate the efficacy of Drakshavalehya in Pandu (IDA)
To evaluate the efficacy of Dhatri loha in Pandu (IDA)
To compare the efficacy of Drakshavalehya and Dhatri loha
ASSESSMENT CRITERIA:
Sl. Assesment
0 1 2 3
No. criteria
1 Hrudrava No Mild Palpitation Palpitation
(palpitation) palpitation palpitation with daily during rest
activities
Conjunctiva Conjunctiva Conjunctiva
2 Pandutwa
No Pallor slightly pale, pale, nail nail grossly
(Pallor)
nail not pale slightly pale pale
Weakness not
Weakness
3 Daurbalya No affecting Weakness
affecting daily
(Weakness) Weakness daily even at rest
activities
activities
Dyspnoea
Dyspnoea
present but Dyspnoea
4 Shwasa No present and
not hindering present even
(Dyspnoea) dyspnoea hindering daily
daily at rest
activities
activities
Mild Exertional Exertional
Arohana
No Exertional Dyspnoea Dyspnoea
5 ayasa
exertional dyspnoea stops daily stops daily
(Exertional
dyspnoea with normal activities activities
dyspnoea)
activities intermittently frequently
7. MATERIALS AND METHODS:
7.1 Source of Data:
Study will be carried out on the patients suffering from Pandu w.s.r to I.D.A
attending O.P.D of A.M.C.H. and special camps conducted will be taken for
study.
7.2 Method of collection of Data:
The study will be carried out on the patients attending the O.P.D and I.P.D of
A.M.C.H, Davangere and will be selected incidentally. These patients will be
registered for the study after examining in detail.
Study will be carried out on the patients diagnosed as suffering from the
classical signs and symptoms of Pandu as explained in the text.
The patients of age group between 16 to 50 years will be selected for the
study, irrespective of Sex, Religion, Occupation and economic status.
Inclusion criteria:
Patients with cardinal features of Pandu w.s.r. to I.D.A
Hb % below 10 g/dl
Age group from 16 to 50 years
Blood picture showing Microcytic Hypochromic, Normocytic Hypochromic cells
Exclusion Criteria:
Anemia resulted from causes other than I.D.A
History of Hematologic diseases where there is active bleeding are excluded.
Anemia patients who are advised for Blood Transfusion irrespective of their
Haemoglobin level will be excluded.
Anemia associated with metabolic disorders will be excluded
Study Design:
A clinical comparative study.
Sample size:
To review the literature on IDA
Total number of patients taken for the study will be divided into TWO groups –
Group A and Group B each consisting of 20 patients(excluding dropouts).
Posology:
In Group A – Drakshavalehya (24gms-0-24gms) with sukoshna jala before food
In Group B –Tab. Dhatriloha (250mg-0-250mg) with sukoshna jala before food
Duration: 3 months
Follow up: Once in 15 days after treatment begins in order to assess the condition
Parameters of study:
Depending upon subjective and objective parameters assessments of response is
made.
Subjective criteria:
Classical symptoms of Pandu are taken before, during, and after treatment like
Balahani (weakness),Hridrava (Palpitation), Pandutva (Pallor) of Nails,
conjunctiva, Arohana Ayasa (exertional dyspnoea).
Objective criteria:
Based on Hb %
Based on Morphological changes in the blood report..
7.3 Does the study require any investigation or intervention to be conducted
on patients OR Other animals? If so describe briefly
YES
The study will be conducted on patients suffering from Pandu Roga w.s.r to
I.D.A only.
Investigations:
Blood: HB%,TC,DC
Peripheral Blood Smear
Urine - Routine
Other investigations if necessary
7.4 Has ethical clearance been obtained from your institution in case of 7.3?
YES
7.5 Adverse drug reaction will be observed, If found will be intimated
7.6 Consent of the patient will be taken
LIST OF REFERENCES:
1) Recent Advances in Hematology,By Dr.Aloe Srivasta,Prof.of medicine, K.T.
Somaiah M.C, Bombay, Sangwi Publications, II Edition-2010,Pg.no.64,
pp-312
2) Anemia-A Global Health Problem, By Dr.V.T.Suxena,Director of Sri
Arabindo Medical Centre, Raipur, Panchami Publishers, II Edition-2010,
Page.no.34, pp-490
3) Anemia-A Global Health Problem,By Dr.V.T.Suxena,Director of Sri Arabindo
Medical Centre,Raipur,Panchami Publishers,II Edition-2010,Page.no.36,
pp-490
4) International Guidelines In Anemia Management by Dr.Sudha Tinaikar,Senior
Physician,Consultant in Lakeside Hospital,Ulsoor,B’lore.
5) a) Agnivesa krita Charaka Samhita revised by Charaka acharya and Dridabala
acharya, edited by Vaidya Yadavaji Trikamji Acharya, Chaukhamba
Surabharati Prakasan, Varanasi, U.P, Edition-2008, pp-738, page no.-591,592
shloka no.-4,10
b)Bhavaprakash,Madhyama khanda,Chikitsa sthana,8th chapter,shloka
no.1,2,Page no.98,99,100,Bhavaprakasha of Sri Bhavamishra,Edited with
Vidyotini Hindi Commentary,By:Pandit Sri Brahma Sankar Mishra(Part
II),Edition 9th, 2005,Chaukambha Sanskrit Sansthana,Post no.1139,K
37/116,Gopal Mandir Lane,Varanasi 22101(India)
c)Vangasena Pandu rogadhikara,shloka no.1 to 12 ,Page no.221,pp.356
d)Yogaratnakara with Vidyotini Hindi Commentary by Vaidya laxmipati
sastri Chaukamba publishers-Varanasi..Edition-2002.shloka.no.1,2,11,
pp-504,Page.no,339,340
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acharya, edited by Vaidya Yadavaji Trikamji Acharya, Chaukhamba
Surabharati Prakasan, Varanasi, U.P, Edition-2008, pp-738, page no.-98,
99,100, shloka no.-40,41,42
b)Bhavaprakash,Madhyama khanda,Chikitsa sthana,8th chapter,shloka
no.27,28,29,Page.no.105,Bhavaprakasha of Sri Bhavamishra,Edited with
Vidyotini Hindi Commentary,By:Pandit Sri Brahma Sankar Mishra(Part
II),Edition 9th 2005,Publication:Chaukamba Sanskrit samsthana,Post
no.1139,K 37/116,Gopal Mandir Lane,Varanasi 22101(India)
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Surbharati-Prakashan,Varanasi,U.P,pp-323,page.no.55,56,shloka no.33,34, 41,
42,43,.
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prakashan.Varanasi
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Pg. no,339,340
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R.Colledge,Brain.R.Walker.International-Editor-John.A.A.Hunter-20thedition-
Pg.1026,1012,1023,pp.1256
b)Harrison’s principles of internal medicine, edited by Dennis L Kasper ET.
AI. Published by M.C. Graw – Hill, United States of America, 16th
edition,Pg.no.588,589.pp-1057
8) Vagbhata, Astangahridayam, Hari Sastri Pardakara vaidya (edited by),
Chaukhamba Orientalia, Varanasi, U.P, Reprint 9 th edition, 2005, pp-956,
Bhaisajya ratnavali of Kaviraj Govind Das Sen edited with Siddhiprada Hindi
commentary by Prof.Siddhinandan Mishra-Chowkamba surbharathi
prakashan.Varanasi
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commentary by Prof.Siddhinandan Mishra-Chowkamba surbharathi
prakashan.Varanasi, page no.459, pp.1116,shloka No.-149,150,151
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