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              What is caffeine?
   Caffeine is an alcaloid compoud, purin
   Caffeine acts as psychoactive stimulant and
    diuretic in humans
   Pure caffeine is white powder
   Caffeine is found in the beans,leaves, and fruit
    of over 60 plants, where it acts as a natural
         Something about history
   People have consume caffeine since the stone age

   They found that for example chewing some seeds stimulates
    their mind and help them feel better.

   The earliest evidence of cocoa use comes from ancient Mayan
    (600 BC) They made a drink from cocoa with vanilla and chile

   As far as 1700 was chocholate introduced to Europe

   Today, global consumption of caffeine has been estimated at
    120 000 tons per annum. In North America, 90% of adults
    consume caffeine daily
   Caffeine is a plant alcaloid

   Most known plants containing caffeine are cocoa, tea
    and coffee, yerba maté and guarana

   Caffeine has no stereoizomers

   Many natural sourcesof caffeine also contain varying
    mixtures of other xantine alkaloids or polyphenols,
    which can form insoluble complexes with caffeine
    Caffeine is completely absorbed by the
     stomach within 45 minutes of ingestion
    Then it is distributed throughout all tissues of
     the body
    The half life of caffeine (our body eliminates
     one half of total consumed amount) varies
     from 3 to 11 hours according to age, liver
     function, consuming some medicaments or
Ingestion- požití
Tissue- tkáň
                         Metabolism 2
      Caffeine is metabolised in the liver by cytochrome
      P450 oxidase enzym systém into

1.    84% paraxanthine (elevated glycerol and free fatty
      acids in the blood plasma)

2.    12% theobromine (dilates blood vessels and
      increase urine volume-is a diuretic)

3.    4% theophylline (relaxes smooth muscles of the
      bronchi and helps to treate astma¨)
Dilates blood vessels- rozšiřuje cévy
Smooth muscles- hladká svalovina
Bronchi- průdušky
   Caffein can leave to caffeinism (you became
    addicted on caffeine)
   Caffein dependency combines with
    nervousnes, irritability, headaches and hearth
   Because caffeine increases the production of
    stomach acid, high usage over time can lead to
    peptic ulcers
Palpitation- bušení srdce
Ulcer- vřed
   Because caffeine is antagonism for the
    neurotransmiter adenosine of nervous systém, it
    makes your body more sensitive to adenosine

   Caffeine tolerance develops very quickly, especially
    among heavy coffee and energy drink consumers.
    Complete tolerance to sleep disruption effects of
    caffeine develops after consuming 400 mg of caffeine
    3 times a day for 7 days.
    Disruption- porucha
    Antagonism- konkurent
                   And that´s all
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Jana and Verča

(And now, let´s have a break and some coffee)

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