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					Safety Data Sheet

Methylene chloride

according to Regulation (EC) No 1907/2006

1. Identification of the substance/preparation and of the company/undertaking
Product name Product code Use Methylene chloride 04 0321 0 - as a solvent in paint removers, aerosols, glues, in plastics processing, metal and textile cleaning (degreasing), in pharmaceutical processes, as a coolant and as an alternative propellant in polyurethane foams Enquiries: F. Hoffmann-La Roche AG Postfach CH-4070 Basel Switzerland Phone Fax E-Mail +41-61/688 54 80 +41-61/681 72 76 info.sds@roche.com Local representation:

Company information

2. Hazards identification
Most important hazards - Limited evidence of a carcinogenic effect.

3. Composition/Information on ingredients
Characterization Chemical name Synonyms chlorinated solvent - Dichloromethane Methylene dichloride Methane dichloride Mechlo DCM Freon 30 75-09-2 602-004-00-3 200 838 9 1593 Ro0940081-000 CH2Cl2

CAS number EU number EINECS number UN number Roche number Empirical formula

Date: 23.4.08/CSE (SEISMO)

Replacing edition of:

31.1.07

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Methylene chloride

Molecular mass

84.94 g/mol
Cl Cl

4. First-aid measures
Eye contact - rinse immediately with tap water for 10 minutes - open eyelids forcibly - always consult ophthalmologist - remove immediately contaminated clothes, wash affected skin with plenty of water - remove the casualty to fresh air and keep him/her calm - avoid mouth to mouth artificial respiration, use respiration equipment - summon a physician immediately treat symptomatically do not administer substances of the adrenaline-ephedrine group risk of pulmonary oedema cave: alcoholic drinks (increase of toxic effect) if necessary blood COHb analysis or breath CO determination (Draeger tube)

Skin contact Inhalation

Note to physician

5. Fire-fighting measures
Suitable extinguishing media Specific hazards - water spray jet, dry powder, foam, carbon dioxide - formation of toxic and corrosive combustion gases (hydrogen chloride (HCl)) possible - consider danger for the environment: dike spilled liquid - vapours are heavier than air - heating containers will cause pressure to rise (risk of bursting or explosion) - Vapours may be invisible and they are heavier than air. They spread on the soil and could penetrate into the sewerage system and into cellars. - substance is hazardous for water: contain fire-fighting wastewater - precipitate gases/vapours/mists with water spray - use self-contained breathing apparatus - cool endangered containers with water spray

Protection of fire-fighters Special method of fire-fighting

Date: 23.4.08/CSE (SEISMO)

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31.1.07

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Methylene chloride

6. Accidental release measures
Personal precautions Environmental protection - if this does not endanger the action force or other people, air sewers and cellars - collect the leaked product by all means available - if possible close leaks - if the substance reaches waters or the sewer system, inform the competent authority - collect liquids by means of sand, earth or another suitable material - collect the product spilled out into ventilated containers equipped with absorption filters

Methods for cleaning up

7. Handling and storage

Handling Technical measures Suitable materials Unsuitable materials Note Storage Storage conditions - protected from light - store in a dry place - room temperature - tightly closing; material: steel, stainless steel, tin-plated iron, dark glass (for small amounts) - transfer and handle only in enclosed systems - local exhaust ventilation necessary - steel, stainless steel, brass, bronze, lead, zinc, tin, copper - magnesium, titanium, PVC, polystyrene, elastomers (rubber) - corrosion of iron and stainless steel when water-moist

Packaging materials

8. Exposure controls/Personal protection

Engineering Measures Monitoring Threshold value (D) air

- see 7.

-

STEL: 150 ppm (possible human carcinogen (cat.3)) STEL: 1040 mg/m3 (possible human carcinogen (cat.3)) AGW: 75 ppm (possible human carcinogen (cat.3)) AGW: 260 mg/m3 (possible human carcinogen (cat.3)) ACGIH-TLV: 50 ppm (animal carcinogen) ACGIH-TLV: 174 mg/m3 (animal carcinogen) ACGIH-TLV: 50 ppm OSHA-PEL: 25 ppm

Threshold value (USA) air

Date: 23.4.08/CSE (SEISMO)

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Methylene chloride

Analytics

- short-term determinations using Dräger tubes for methylene chloride - adsorption on activated charcoal tubes, desorption and gas chromatographic determination - CH2Cl2 100/a - CH2Cl2 50a-L - smell threshold value: 25-600 ppm (90-2100 mg/m³)

Air measuring tubes Note Personal protective equipment Respiratory protection Hand protection Eye protection

- respirator with independent air supply or protective mask with activated charcoal filter - protective gloves (NBR Acrylnitril-Butadien-Rubber) - safety glasses

9. Physical and chemical properties
Colour colourless clear liquid sweetish, chloroform-like 1.33 g/cm3 (20 °C) 0.43 mPa*s (20 °C) 27.4 mN/m (20 °C) n 20 1.424 D 20’000 mg/l, water (20 °C) 13’000 mg/l, water (25 °C) soluble, oils and fats miscible, ethanol miscible, ether miscible, dimethyl formamide miscible, acetone miscible, chloroform miscible, carbon tetrachloride miscible, TBME (tert-butylmethylether) miscible, petroleum ether miscible, tert-Butylchloride log Pow 1.25 (octanol/water) -95 °C 40 °C (1013 mbar) 475 mbar (20 °C) 709 mbar (30 °C) 605 °C

Form Odour Density Viscosity Surface tension Refraction index Solubility

Partition coefficient Melting temperature Boiling temperature Vapour pressure Ignition point (liquid)

Date: 23.4.08/CSE (SEISMO)

Replacing edition of:

31.1.07

Page: 4/7

Methylene chloride

Explosion limits Note

lower: 13 vol %; upper: 22 vol % - no flash point, but inflammable in air with only 0.5 vol% of methanol at 27°C

10. Stability and reactivity
Stability Conditions to avoid - stable under the conditions mentioned in chapter 7 - light - humidity (gradual decomposition) - higher temperatures (above 60 °C) - alkali metals (risk of explosion), alkaline earth metals (strong exothermic reaction), air (explosive mixture), metal powders (strong exothermic reaction), sodium azide (risk of explosion), perchloric acid (risk of explosion), nitric acid (risk of explosion), sodium amide (strong exothermic reaction) - aluminium (at elevated temperature) - only combustible in an atmosphere rich in oxygen - strong exothermal decomposition above 90°C

Materials to avoid

Note

11. Toxicological information
Acute toxicity - LD50 - LC50 - LC50 1’600 16’100 14’400 mg/kg ppm mg/kg (oral, rat) (inhal., rat, 6 h) (inhal., mouse, 7 h)

Local effects

eye: irritant (man); painful irritations mucous membranes: irritant (man) upper respiratory pathways: irritant (man) skin: irritant (man) skin: degreasing (man)

Mutagenicity Carcinogenicity Reproduction toxicity Note

- mutagenic (various in vitro test systems) - IARC Group 2B: Possibly carcinogenic to humans - not teratogenic - chronical overexposure can lead to blood, liver and kidney damage, pulmonary and cerebral oedema - readily resorbed through the skin - toxic effect on the central nervous system - possible skin irritation on repeated or prolonged contact - upon inhalation or oral uptake, depending on the period and amount, the following symptoms can occur: headache, dizziness, fatigue, nausea, vomiting, arrhythmia, euphoria, unconsciousness, apnoea, death - caution: alcohol potentiates the effect!

Date: 23.4.08/CSE (SEISMO)

Replacing edition of:

31.1.07

Page: 5/7

Methylene chloride

12. Ecological information
Ready biodegradability Inherent biodegradability Ecotoxicity - not readily biodegradable - well inherently biodegradable 100 %, 28 d - barely toxic for fish (fathead minnow) LC50 (96 h) 193 mg/l - barely toxic for fish (rainbow trout) LC50 210 mg/l LC100 330 mg/l LC0 130 mg/l (OECD No. 203) - barely toxic for fish (golden orfe) LC50 (48 h) ~ 430 mg/l - barely toxic for planktonic crustaceans (Daphnia magna) NOEC (48 h) 68 mg/l EC50 (48 h) 220 mg/l - barely toxic for algae (green algae) EC0 125 mg/l - barely toxic for protozoa (Colpoda sp.) LC0 1000 mg/l - barely toxic for microorganisms (Pseudomonas putida) EC0 500 mg/l - observe local/national regulations - easily stripping off from water, low bioaccumulation potential - no significant hydrolysis or photolysis in water - in the air indirect photooxidation by hydroxyl radicals, half-life 6 months

Air pollution Note

13. Disposal considerations
Waste from residues - distill smaller quantities - larger amounts: special incineration for chlorinated solvents - observe local/national regulations regarding waste disposal

Date: 23.4.08/CSE (SEISMO)

Replacing edition of:

31.1.07

Page: 6/7

Methylene chloride

14. Transport information

IATA

Class 6.1

UN/ID 1593

PG III

PI 605/612

Label 6.1

IMDG

Class 6.1

UN 1593

PG III

EmS F-A S-A

PI P001/IBC03

Label 6.1

Mark

RID/ADR

Class 6.1

UN 1593

PG III

Haz.no 60

PI P001/IBC03

Label 6.1

Classif.code T1

Proper shipping name

DICHLOROMETHANE

15. Regulatory information
Classification and labelling according to EU directives

Xn R40 S23 S24/25 S36/37 Water hazard class (Germany) Limited evidence of a carcinogenic effect. Do not breathe (vapour). Avoid contact with skin and eyes. Wear suitable protective clothing and gloves. 2: hazardous for water (according to annex 1 or 2 of directive VwVwS of 17.05.1999)

16. Other information
Safety-lab number Note Edition documentation - BS-3589 - 1 ppm = 3.53 mg/m3 - changes from previous version in sections 1, 2, 3, 8, 11, 16

The information in this safety data sheet is based on current scientific knowledge. It should not be taken as expressing or implying any warranty concerning product characteristics.
Date: 23.4.08/CSE (SEISMO) Replacing edition of: 31.1.07 Page: 7/7


				
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