alpha by biomarkers - the Center for Biomarkers in Imaging

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					                        Disease /
                        Medical                  Imaging
Biomarker               condition                Technique          Investigators     Comments
18 F-fluorodeoxy-       Pancreatic carcinoma     PET                Fischman AJ
glucose

99mTc labeled           Colorectal carcinoma     SPECT              Fischman AJ       Phase III clinical
monoclonal antibody                                                                   trial with
                                                                                      HumaSPECT-Tc
Abnormal lymphatic      Lymphatic extension      MRI                Hahn PF           MR Lymphangio-
uptake of tracer        of pelvic malignancy                        Harisinghani M    graphy using
                        (gynecological                              Mueller PR        ultrasmall superpara-
                        oncology)                                   Saini S           magnetic iron oxide
                                                                    Weissleder R

ACCD activation         Attention deficit        fMRI               Bush G
(anterior cingulate     hyperactivity disorder   PET                Fischman A
cortex division)        (ADHD)                                      Rosen B
Acinar cell receptor    Pancreatic function      MRI                Brady TJ          Secretin
binding                                                             Shen TT           monocrystalline iron
                                                                    Weissleder R      oxide nanoparticles
                                                                                      (MION)

Acute bronchial         Respiratory syncytial    CT                 McLoud TC
dilatation              virus                                       Shepard J
Wall thickening
Altered vascular and    Asphyxia                 CT                 Gonzalez RG
tissue permeability                                                 Grant E

Anatomic disruption of Aortic dissection         US                 Gonzalez R
arterial wall                                    CT                 Waltman A
                                                 MRI
                                                 Angiography
Anatomic disruption of Carotid dissection        US                 Gonzalez R
arterial wall                                    CT / CTA           Waltman A
                                                 MRI / MRA
                                                 Angiography
Anatomic disruption of Intracranial arterial     CTA                Gonzalez R
arterial wall          dissection                MRA                Lev MH
                                                 Angiography        Waltman A
Aneurysmal wall         Inflammatory             CT                 Brady T
thickness               abdominal aortic                            Saini S
                        aneurysm (IAAA)                             Waltman A
Angiogenesis            Breast neoplasm          US                 O'Neill MJ        Microbubble
                                                                                      contrast agents
Anterior cingulate size Alzheimer's disease      MRI                Hyman B           Can distinguish
and thickness                                                                         normal from mild
                                                                                      AD with 93%
                                                                                      accuracy
Anti-tumor antibody     Neoplasm / primary       Optical            Ntziachristos V   Targeted
                        and secondary                               Weissleder R      Fluorochromes

Apoptosis               Neoplasm / primary       Optical            Ntziachristos V   Active, stable
Caspase-1               and secondary                               Weissleder R      Fluorochromes
Caspase-3
Apoptosis               Neoplasm / primary       Optical            Ntziachristos V   Active, stable
Phosphatidylserine      and secondary                               Weissleder R      Fluorochromes

Apparent diffusion      Neurodegenerative        fMRI               Jenkins BG
constant (ADC)          disorders                MRI / diffusion    Kennedy D
                                                 weighted imaging   Rosas HD
                                                                    Rosen B
Apparent diffusion        Stroke                 Diffusion weighted Kennedy D
constant (ADC)                                   imaging            Lo E
                                                 fMRI               Rosen B
                                                 MRI (morphometry)

Arterial calcification    Arteriosclerosis /     CT                  Brady T
                          peripheral

Arterial calcification    Atherosclerosis /      CT                  Brady T
                          central

Arterial calcification    Coronary artery        CT                  Brady T
                          disease

Articular cartilage and Cartilage                MRI                 Palmer WE       MR using fat-
subchondral bone        abnormalities                                                suppressed SPGR
thickness                                                                            images
Articular cartilage     Arthritis /              Plain radiographs   Palmer W
thickness               inflammatory             MRI                 Rosenthal DI
Articular cartilage     Arthritis / rheumatoid   Plain radiographs   Palmer W
thickness                                        MRI                 Rosenthal DI
Articular cartilage     Osteoarthritis           Plain radiographs   Palmer W
thickness                                        MRI                 Rosenthal DI
Articular cartilage     Joint injury / hip and   Co-planar MRI       Palmer WE       MR using fat-
volume                  knee                                         Rosenberg AE    saturated 3D spoiled
                                                                     Rosenthal DI    gradient-echo
                                                                                     images (SPGR)

Articular labrum       SLAP lesions of the       MR arthrography     Bencardino JT
fraying                shoulder                                      Palmer WE
Atherosclerotic plaque Vulnerable plaque         Thermography        Brady T
temperature                                                          Lev M
                                                                     Waltman A

Basal ganglia /           Huntington's disease   MRI                 Harris G
putamen volume
Bicep anchor avulsion     SLAP lesions of the    MR arthrography     Bencardino JT
                          shoulder                                   Palmer WE
Biliary ductal dilatation Biliary obstruction    US                  Hahn P
                                                 CT                  Mueller P
                                                 MRI
Biliary ductal dilatation Biliary parasitic      US                  Hahn P
                          disease                CT                  Mueller P
                                                 MRI                 O'Neill MJ
Biliary ductal dilatation Cholangitis            MRI                 Prasad S        MR cholangio-
                                                                     Sahani D        pancreatography

Biliary ductal dilatation Choledo-cholithiasis   US                  Hahn PF
                                                 CT                  O'Neill MJ
                                                 MRI                 Mueller P

Blood oxygen level        Neurodegenerative      fMRI                Jenkins BG
depletion                 disorders              MRI / diffusion     Kennedy D
                                                 weighted imaging    Rosas HD
                                                                     Rosen B
Blood oxygen level        Dementia               fMRI                Rosen B
depletion (BOLD)
Blood-tumor barrier       Glioma                 MRI                 Gonzalez RG
permeability (BTP)                               fMRI                Kwong KK
                                                                     Sorensen AG
                                                                     Weissleder R
Body fat               AIDS wasting         CT                  Rosenthal DI
composition            syndrome




Body fat composition   Obesity              Quantitative CT     Rosenthal DI
                                            MRI
                                            US

Bone fill score and    Bone fracture /      US                  O'Neill MJ        Animal study
penetration depth      healing and                                                Bone healing
                       distraction                                                assessed by
                       osteogenesis                                               increased fill and
                       wounds                                                     decreased
                                                                                  penetration depth

Bone mineral density   Osteopenia           Plain radiographs   Rosenthal DI      Must establish bone
                                            Dual energy X-ray                     strength as well as
                                            absorptiometry                        density
                                            (DEXA)
                                            CT

Bone mineral density   Osteoporosis         Plain radiographs   Rosenthal DI      Must establish bone
                                            Dual energy X-ray                     strength as well as
                                            absorptiometry                        density
                                            (DEXA)
                                            CT

Bowel wall             Crohn's disease      MR enteroclysis     Hahn P            Use of experimental
differentiation                                                                   oral contrast Kaolin,
                                                                                  locus bean gum,
                                                                                  methylcellulose +
                                                                                  Barium

Bowel wall             Inflammatory bowl    MRI                 Hahn P            Tissue FISP pulse
thickening             disease                                                    sequence
                       (IBD)
Cartilage thickness    Osteoarthritis       Intra-articular   Palmer WE
                                            Optical coherence
                                            topography

Cathepsin D            Neoplasm / primary   Optical             Ntziachristos V   Active, stable
                       and secondary                            Weissleder R      Fluorochromes

Caudate lobe           Cirrhosis            MRI                 Hahn PF           Discrimination of
enlargement                                 CT                  Sahani D          alcohol from virus-
                                                                                  induced cirrhosis
Cerebral blood flow    Alzheimer's disease Perfusion        Hoge R
                                           weighted imaging
                                           / Arterial spin
                                           labeling

Cerebral blood flow    Alzheimer's disease Optical              Boas D            Combining of
(CBF)                                                           Dunn A            multi-wavelength
                                                                                  and laser speckle
                                                                                  contrast imaging
Cerebral blood flow      Brain function         MRI                   Belliveau       Response to stimuli
(CBF )                                          fMRI                  Kwong K
                                                PET                   Rosen BR
Cerebral blood flow      Brain development      Optical Imaging       Boas D          Diffuse optical
(CBF)                                                                 Dunn A          imaging (DOI)
Cerebral blood flow      CNS neoplasm /         Optical               Boas D          Diffuse optical
(CBF)                    primary and                                  Dunn A          imagine (DOI)
                         secondary, presence
                         and viability

Cerebral blood flow Dementia                    MRI / arterial spin   Hoge R
(CBF)                                           labeling
Cerebral blood flow Epilepsy                    MRI / arterial spin   Hoge R
(CBF)                                           labeling              Kwong KK
Cerebral blood flow Migraine                    Laser speckle         Boas D
(CBF)                                           contrast imaging      Bolay
                                                Diffuse optical       Dunn A
                                                topography

Cerebral Blood flow      Stroke                 Optical imaging       Boas, D
(CBF)                                                                 Dunn, A
                                                                      Lo E
Cerebral blood flow      Parkinson’s disease    MRI / Arterial spin   Hoge R
(CBF)                                           labeling
Cerebral blood flow      Migraine               Diffusion / perfusion Grant E
(CBF)                                           weighted imaging       Schaefer P
                                                fMRI                   Sorensen AG
                                                                       Rosen BR
Cerebral blood flow      Alzheimer's disease    SPECT                  Harris G
(CBF)                                           fMRI                   Gonzalez RG
                                                                       Sorensen AG
Cerebral blood flow      Stroke                 MRI (combined          Harris G       MTT helps to stratify
(CBF)                                           Arterial spin labeling Hoge R         patients in clinical
                                                and Dynamic            Ostergaard L   trials
                                                susceptibility         Rosen B        MR perfusion
                                                contrast)              Sorensen AG    territory imaging
                                                CAPTIVE                Wald LL

Cerebral blood flow      Stroke / ischemic      CAPTIVE MRI           Bogdanov A
(CBF)                                                                 Jenkins B
                                                                      Kwong K
                                                                      Weissleder R
Cerebral   blood flow   Glioma                 MRI                    Gonzalez RG
(CBF)                                          fMRI                   Sorensen AG
                                                                      Rosen B
Cerebral   blood flow   Schizophrenia          PET                    Alpert N        Regional activation
(CBF)                                                                 Fischman A      during cognitive
                                                                      Heckers S       paradigms
                                                                      Rauch SL
                                                                      Schaefer P
Cerebral   blood volume Brain function / drugs fMRI                   Jenkins B       Response to stimuli
(CBV)                   of abuse                                      Kosofsky B
                                                                      Mandeville JB
                                                                      Rosen B
Cerebral   blood volume Stroke                 MRI (combined          Harris G        MTT helps to stratify
(CBV)                                          Arterial spin labeling Hoge R          patients in clinical
                                               and Dynamic            Ostergaard L    trials
                                               susceptibility         Rosen B         MR perfusion
                                               contrast)              Sorensen AG     territory imaging
                                               CAPTIVE                Wald LL
Cerebral blood volume Alzheimer's disease       SPECT                 Harris G
(CBV)                                           fMRI                  Gonzalez RG
                                                                      Sorensen AG
Cerebral blood volume Migraine                  Diffusion / perfusion Grant E
(CBV)                                           weighted imaging      Schaefer P
                                                fMRI                  Sorensen AG
                                                                      Rosen BR
Cerebral blood volume Parkinson’s disease       MRI / Arterial spin   Hoge R
(CBV)                                           labeling

Cerebral blood volume Glioma                    MRI                 Gonzalez RG
(CBV)                                           fMRI                Sorensen AG
                                                                    Rosen B
Change in local tissue   Neoplasm / primary     CT                  Palmer WE       Mutlicenter Trail
density or contrast      and secondary          MRI                 Rosenthal DI    with 367 patients -
enhancement                                                                         CT and MRI equally
                                                                                    reliable for diagnosis

Chemotactic peptide      Pancreatitis           SPECT               Fischman AJ     Via 99mTc labeled
uptake                                                                              peptide analog




Choline                  CNS AIDS /             MRS                 Gonzalez R
                         neuroinflammation                          Schaefer P
                         neurodegeneration                          Schwamm LH
Choline                  Hepatic                MRS                 Grant E
                         encephalopathy                             Jenkins BG
                                                                    Schaefer P
Choline                  CNS neoplasm /         MRS                 Gonzalez R      Metabolism, tumor
                         primary and                                Husiman TA      viability and
                         secondary                                  Sorensen AG     response to therapy

Choline / sodium (NA) Multiple sclerosis        MRS                 Jenkins B
ratio                                                               Gonzalez RG
Creatine / sodium
(NA) ratio
Choline : creatine ratio Huntington's disease   MRS                 Jenkins BG
                                                                    Rosen B
CMRO2                    Stroke                 fMRI                Boas D          NIRS agrees well
                                                Diffuse optical     Mandeville JB   with fMRI, useful in
                                                topography (Near    Strangman G     longitudinal studies
                                                infrared
                                                spectroscopy)
Comparative              Multiple sclerosis     MRI            Jenkins B
brainstem analysis                                             Rosen BR
                                                               Stufflebeam SM
Contrast enhanced       Pancreatic mass      MRI cholangio -   Prasad S
tissue characterization                      pancreatography   Sahani D
                                                               Saini S
Cortical thickness      Schizophrenia        MRI (morphometry) Fischl B
                                                               Harris G
                                                               Kennedy D
                                                               Kuperberg G
Cortical activation     Obsessive compulsive fMRI              Fischman A
during provoked         disorder             PET               Rauch SL
conditions                                   SPECT             Rosen BR
Cortical activation     Stroke / recovery    fMRI              Schaechter J
during sensorimotor                                            Rosen BR
tasks
Cortical activity        Pain                   fMRI                 Fischman A
                                                PET                  Halgren E
                                                SPECT                Rosen B
                                                MEG                  Sorensen AG
                                                                     Stuffelbeam SM
Cortical dysplasia       Epilepsy               MRI / MEG            Dale A
                                                fMRI                 Grant E
                                                                     Mandeville J
                                                                     Rosen B
                                                                     Stufflebeam SM
                                                                     Wald LL
Cortical spreading       Migraine               Blood oxygen level   Hadjikhani N     Signal changes
depression (CSD)                                dependent (BOLD)     Rosen BR         measured during
                                                fMRI                 Sorensen AG      visual aura
Cortical surface         Bone fracture          Plain radiographs    Palmer W
disruption                                                           Rosenthal DI
Cortical thickness       Huntington's disease   fMRI                 Dale A
                                                MRI morphometry      Fischl B
                                                                     Harris G
                                                                     Kennedy D
                                                                     Rosas D
Cortical thickness       Multiple sclerosis     fMRI                 Fischl B
                                                MRI morphometry      Kuperberg G

Cortical thickness       Obsessive compulsive MRI (morphometry) Kennedy D
                         disorder

Cortical thickness and Attention deficit        MRI (morphometry) Kennedy D
asymmetry              hyperactivity disorder
                       (ADHD)
Cortical thickness,    Brain development /      MRI morphometry      Caviness VS
volume and location    -anencephaly             fMRI                 Dale A
                       -microcephaly                                 Fischl B
                       -holoprosencephaly                            Kennedy D

Cyst composition /      Intra-abdominal         US                   Mueller P
tissue characterization abscess                 CT
                                                MRI
Cyst composition /      Arthritis / septic      PET                  Palmer W
tissue characterization                                              Rosenthal DI

Cyst composition /      Fibrocystic change      US                   Kopans DB
tissue characterization                         CT
                                                MRI
Cyst composition /      Ganglion cyst           US                   Rosenthal DI
tissue characterization                         CT
                                                MRI
Cyst composition /      Renal neoplasm /        US                   Mueller PR
tissue characterization primary and             CT
                        secondary               MRI
Cyst composition /      Synovial cell sarcoma   US                   Rosenthal DI
tissue characterization                         CT
                                                MRI
Cyst composition /      Simple renal cysts      US                   Mueller PR
tissue characterization                         CT
Soft tissue                                     MRI
inflammation

Cystic architecture /   Synovial cyst           US                   Palmer W
tissue characterization                         CT                   Rosenthal DI
                                                MRI
Cystic nodal             Thyroid carcinoma      US                   Hahn PF
metastases                                                           Harisinghani M
                                                                     Mueller PR
                                                                     O'Neill MJ
Decreased N-          Multiple sclerosis        MRS                  Jenkins B
acetylaspartate (NAA)                                                Gonzalez RG

Decreased regional       Renal disease          PET                Alpert NM
blood flow                                                         Fischman AJ
Degree of                Pancreatic adrenal     Multidetector CT   Boland GW
circumferential vessel   carcinoma              angiography (MDCT) Mueller PR
involvement                                     / CTA              Saini S
Diffuse cerebral         Cerebral malaria       CT                 Gonzalez RG
edema with
thalamic +/-
cerebellar hypo-
attenuation
Diffuse cerebral         Infectious disease / CT                     Gonzalez RG
edema with               cerebral malaria
thalamic +/-
cerebellar hypo-
attenuation
Directed molecular       HIV                    MRI                  Weissleder R
probes                                          PET
                                                Optical
Directed molecular       Huntington's disease   MRI                  Fischman A
probes                                          PET                  Weissleder R
                                                Optical
Directed molecular       Neoplasm / primary     MRI                  Fischman AJ
probes                   and secondary          PET                  Hunter GJ
                                                Optical              Weissleder R
Directed molecular       Parkinson’s disease    PET                  Weissleder R
probes                                          Optical
Directed molecular       Alzheimer's disease    PET                  Fischman A       Animal modeling
probes                                          SPECT                Weissleder R     Optical with
                                                Optical                               exogenous contrast
                                                                                      agents
Directed molecular       Diabetes               MRI                  Moore A
probes for beta cell                                                 Bogdanov AJ
mass                                                                 Weissleder R

Distribution and       Rotator cuff injury      MR arthrography      Palmer WE        Distinguishes full
leakage of intra-                                                                     from partial
articular administered                                                                thickness tears
contrast media

Dopa decarboxylase       Dyskinesia (PNKD)      PET                  Fischman A
activity

Dopamine binding         Parkinson’s disease    SPECT (using I-123   Fischman A
potential                                       altropane)           Halpern E
                                                                     Sahani D
Dopamine transporter Parkinson’s disease        SPECT (using I-123   Fischman A
(DAT) density                                   altropane)           Halpern E
                                                                     Sahani D
Dopamine transporter Attention deficit          SPECT                Fischman A
density              hyperactivity disorder                          Rauch SL
                     (ADHD)
Dopaminergic         Parkinson’s disease        fMRI                 Fishman A        Pet using 11C-CRT
neurotransmitter                                PET                  Livni E
activity                                                             Rosen B
Ductal dilatation        Cholangitis               MRI                      Prasad S          MR cholangio-
                                                                            Sahani D          pancreatography

Ductal irregularity or   Pancreatitis              MRI                      Prasad S          Visualized by MR
obstruction                                                                 Sahani D          cholanio-
                                                                            Saini S           pancreatography
                                                                                              (MRCP)

Early diffusion          Asphyxia                  Diffusion weighted       Grant E
changes                                            imaging                  Schaefer P
                                                                            Sorensen AG
Edema / change in        Trauma                    MRI                      Palmer W
signal intensity and                               Diffusion weighted       Rosenthal DI
apparent diffusion                                 imaging
constant
Embolism volume          Pulmonary embolism        MRI                      Weissleder R      Via monocrystalline
                                                                                              iron oxide
                                                                                              nanoparticles
                                                                                              (MION)

Entorhinal cortex        Alzheimer's disease       MRI                      Hyman B           Can distinguish
                                                                                              normal from mild
                                                                                              AD with 93%
                                                                                              accuracy
Enzymatic activity       Neoplasm / primary        Optical                  Weissleder R      Rodent model
                         and secondary

Fibrillations            Osteoarthritis            Intra-articular   Palmer WE
                                                   Optical coherence
                                                   topography

Fibrosis                 Osteoarthritis            Intra-articular   Palmer WE
                                                   Optical coherence
                                                   topography

Fibrous cap thickness    Vulnerable plaque         Optical coherence        Weissleder R
                                                   topography


Flow heterogeneity       Stroke                    MRI (combined            Harris G          MTT helps to stratify
(FH)                                               Arterial spin labeling   Hoge R            patients in clinical
                                                   and Dynamic              Ostergaard L      trials
                                                   susceptibility           Rosen B           MR perfusion
                                                   contrast)                Sorensen AG       territory imaging
                                                   CAPTIVE                  Wald LL

Fluorescent proteins / Neoplasm / primary          Macroscopic              Ntziachristos V   Green fluorescence
exogenous              and secondary               fluorescence             Weissleder R      proteins (GFPs)
                                                   reflective imagine                         Ds Red
                                                   (FRI)                                      Hc Red
                                                   Fluorescence
                                                   molecular
                                                   tomography (FMT)

Focal atrophy            Brain injury / toxicity   MRI                      Caviness VS
                         and trauma                                         Kennedy D
Focal brain uptake       CNS AIDS /                PET                      Fischman A
                         fungal and                SPECT
                         opportunistic
                         infections
Folate receptor          Neoplasm / primary        Optical                  Ntziachristos V   Targeted
                         and secondary                                      Weissleder R      Fluorochromes
Frontal language area Autism                  MRI    Caviness VS    Reversal of
                                                     Harris G       morphometric
                                                     Kennedy D      asymmetry in
                                                                    frontal language
                                                                    area
Frontal language area Autism                  fMRI   Harris G       Abnormal fMRI
                                                                    activation of frontal
                                                                    language areas
                                                                    during semantic
                                                                    language tasks

Gallbladder wall     Cholecystitis            US     Hahn P
thickening                                    CT     Mueller P
                                              MRI    O'Neill MJ

Gallstones           Cholelithiasis           US     Hahn P
                                              CT     Mueller P
                                              MRI    O'Neill MJ

Gallstones           Cholecystitis            US     Hahn P
                                              CT     Mueller P
                                              MRI    O'Neill MJ

Glucose              Hepatic                  MRS    Grant E
                     encephalopathy                  Jenkins BG
                                                     Schaefer P
Glucose metabolism   Breast neoplasm          PET    Alpert NM
                                                     Choi NC
                                                     Fischman AJ
Glucose metabolism   Head and neck            PET    Alpert N       Non-specific marker
                     neoplasm / primary              Choi N         with wide variety of
                     and secondary                   Fischman A     applications

Glucose metabolism   Hepatic neoplasm /       PET    Fischman AJ    Non-specific marker
                     primary and                                    with wide variety of
                     secondary                                      applications

Glucose metabolism   Lung neoplasm / non      PET    Choi NC        Pilot trial in NSCLC
                     small cell carcinoma            Fischman AJ    showed good
                                                     Weissleder R   inverse correlation
                                                                    between MR post
                                                                    radiation and
                                                                    outcomes

Glucose metabolism   Osseous neoplasm /       PET    Fischman AJ
                     primary and
                     secondary
Glucose metabolism   Ovarian neoplasm /       PET    Fischman AJ    Non-specific marker
                     presence and viability                         with wide variety of
                                                                    applications

Glucose metabolism   Pulmonary neoplasm / PET        Fischman AJ    Non-specific marker
                     presence and viability                         with wide variety of
                                                                    applications

Glucose metabolism   Renal neoplasm /       PET      Fischman AJ
                     primary and
                     secondary
Glucose metabolism   Soft tissue neoplasm / PET      Fischman AJ    Non-specific marker
                     primary and                                    with wide variety of
                     secondary                                      applications
Glucose metabolism      CNS neoplasm /           PET                   Alpert N          Non-specific marker
                        primary and                                    Choi N            with wide variety of
                        secondary, presence                            Fischman A        applications
                        and viability                                  Kennedy D
                                                                       Rosen B
Glucose transporter     Neoplasm / primary       Optical               Ntziachristos V   Targeted
                        and secondary                                  Weissleder R      Fluorochromes

Glucose uptake          Glioma                   PET                   Fischman A
                                                                       Kennedy D
                                                                       Rosen B
Ground-glass            Respiratory syncytial    CT                    McLoud TC
appearance              virus                                          Shepard J
Hippocampal size        Alzheimer's disease      MRI                   Dale A            Accurately indicates
                                                 Quantitative          Hyman B           absence of disease
                                                 volumetric            Fischl B          progression in
                                                 morphometry           Kennedy D         therapeutic trials -
                                                                                         allows markedly
                                                                                         reduced subject
                                                                                         numbers

Hippuran clearance      Renal disease            PET                   Alpert NM
                                                                       Fischman AJ
Human transferrin       Neoplasm / primary       MRI                   Weissleder R      Receptor binding
receptor                and secondary                                                    probe linking
                                                                                         transferrin and
                                                                                         monocrystalline iron
                                                                                         oxide (Tf-MION)

Hyperperfusion          Epilepsy                 MRI / arterial spin   Hoge R
                                                 labeling              Kwong KK
Increased abdominal AIDS wasting                 Quantitative CT       Rosenthal DI
visceral fat associated syndrome /               Dual energy X-ray
with decreased bone     lipodystrophy            absorptiometry
mineral density                                  (DEXA)

Increased Cerebral      HIV                      fMRI                  Gonzalez RG       Cerebral injury
blood volume (CBV)                                                     Hunter G          related to HIV
                                                                                         infection
Increased             Allergic drug              CT                    McLoud TC
pulmonary             reaction                                         Shepard J
interstitial markings

Increased             Connective tissue          CT                    McLoud TC
pulmonary             disorders                                        Shepard J
interstitial markings

Increased pulmonary     Interstitial pulmonary   CT                    McLoud T
interstitial markings   edema                                          Shepard J




Increased pulmonary     Lymphangio-              CT                    McLoud TC
interstitial markings   carcinomatosis                                 Mueller PR
                                                                       Shepard J
                                                                       Weissleder R
Increased pulmonary     Pulmonary infection      CT                    McLoud TC
interstitial markings                                                  Shepard J
Increased synovial       Arthritis / septic      MRI                  Palmer W
glucose                                                               Rosenthal DI
metabolism


Increased synovial       Arthritis /             PET                  Fischman AJ
glucose metabolism       inflammatory                                 Palmer W
                                                                      Rosenthal DI
Increased synovial       Pigmented villonodular PET                   Fischman AJ
glucose metabolism       synovitis                                    Palmer W
                                                                      Rosenthal DI
Increasing periosteal    Osteoarticular allograft MRI                 Palmer WE      3-4 months post
and endosteal            imaging                                      Rosenthal DI   allograft /
enhancement                                                                          represents vascular
                                                                                     ingrowth and early
                                                                                     skeletal repair

Infiltration of tunica   Rectal carcinoma /      MRI                  Hahn P
muscularis               advanced staging        Multidetector CT     Saini S
Presence of positive                             angiography (MDCT)   O'Neill MJ
nodes                                            US                   Mueller P

Inflammation             Crohn's disease         MR enteroclysis      Hahn P         Use of experimental
                                                                                     oral contrast Kaolin,
                                                                                     locus bean gum,
                                                                                     methylcellulose +
                                                                                     Barium

Intraluminal             Gastrointestinal        SPECT                Fischman AJ
hemorrhage               bleeding
Intravascular            Acute myocardial        MRI                  Brady T
thrombus                 infarction
Intravascular            Arterial embolism      CT                    Waltman A
thrombus                                        MRI
                                                Angiography
Intravascular            Deep venous            US                    O’Neill MJ
thrombus                 thrombosis             MRI                   Waltman A
                                                Angiography
Intravascular            Portal vein thrombosis US                    Hahn P
thrombus                                        CT                    Mueller P
                                                MRI                   O’Neill MJ
                                                Angiography           Waltman A
Intravascular            Pulmonary embolism CT                        McLoud T
thrombus
Intravascular            Stroke                  CT / CTA              Caviness VS
thrombus                                         MRI / MRA             Gonzalez RG
                                                 Angiography           Schaefer P
                                                                       Sorensen AG
Ischemic brain tissue    Stroke / ischemic       Diffusion / perfusion Gonzalez R
                                                 weighted imaging      Harris G
                                                 MRI                   Sorensen AG
                                                 CT perfusion
                                                 CTA

Joint space narrowing    Arthritis               Plain radiographs    Palmer W
                                                                      Rosenthal DI
Lactate                  Hepatic                 MRS                  Grant E
                         encephalopathy                               Jenkins BG
                                                                      Schaefer P
Lactate                  Huntington's disease    MRS                  Jenkins BG
                                                                      Rosen B
Lactate                CNS neoplasm /          MRS                Gonzalez R       Metabolism, tumor
                       primary and                                Husiman TA       viability and
                       secondary                                  Sorensen AG      response to therapy

Lactate : choline ratio Asphyxia               MRS                Jenkins B

Lesion detection       Hepatic neoplasm /      MRI                Hahn PF          Increased SNR and
                       primary and                                Harisinghani M   CNR with liver
                       secondary                                  Saini S          specific contrast
                                                                  Weissleder R     agent GD-BOPTA
                                                                                   and mangafodipir

Lesion volume          Adenopathy,             US                 Harisinghani M   Anatomic marker of
                       lymphoma and            CT                 Mueller PR       disease presence
                       metastatic disease      MRI                O’Neill MJ
                                                                  Saini S
Lesion volume          CNS neoplasm /          CT                 Gonzalez R       Anatomic marker of
                       primary and             MRI morphometry    Harris G         disease presence
                       secondary                                  Kennedy D        Response to therapy
                                                                  Lev
                                                                  Schaefer P
                                                                  Sorensen AG
Lesion volume          Head and neck           CT                 Gonzalez R       Anatomic marker of
                       neoplasm / primary      MRI                Lev MH           disease presence
                       and secondary                              Schaefer P
                                                                  Schwamm
                                                                  Sorensen AG
Lesion volume          Hepatic neoplasm /      US                 Harris G         Anatomic marker of
                       primary and             CT                 Mueller PR       disease presence
                       secondary               MRI                O’Neill MJ
                                                                  Saini S
Lesion volume          Lung neoplasm /         CT                 Hunter GJ        Anatomic marker of
                       primary and             MRI                                 disease presence
                       secondary
Lesion volume          Renal neoplasm /        US                 Mueller PR       Anatomic marker of
                       primary and             CT                 O’Neill MJ       disease presence
                       secondary               MRI                Saini S
Leukocyte              Abscess                 SPECT              Fischman AJ      Tc-99m HMPAO
accumulation                                                                       improvement over
                                                                                   Tl-201 and Ga-67



Leukocyte              Osteomyelitis           Nuclear medicine   Fischman AJ      Radiolabled IL-8
accumulation                                                                       accumulation
Leukocyte              Soft tissue infection   Nuclear medicine   Fischman AJ
accumulation

Ligament tears         Ankle injury            MR arthrography    Palmer WE        Predicts sensitivity
                                                                                   for ankle
                                                                                   impingement
                                                                                   syndromes

Liver tissue           Cholangio-carcinoma     MRI                Hahn PF          Using combined
characterization                                                  Halpern EF       ferrumoxide / Gd-
                                                                  Sahani D         DPTA
Liver tissue           Hepatic cysts           MRI                Hahn PF          Using ultrasmall
characterization                               US                 Harisinghani M   superpara-magnetic
                                                                  Mueller PR       iron oxide,
                                                                  O'Neill MJ       mangafodipir
                                                                  Weissleder R     trisodium
Liver tissue          Hepatic focal nodular   MRI                 Hahn PF           Using combined
characterization      hyperplasia                                 Halpern EF        ferrumoxide / Gd-
                                                                  Sahani D          DPTA

Liver tissue          Hepatic focal nodular   MRI                 Hahn PF           Using ultrasmall
characterization      hyperplasia                                 Harisinghani M    superpara-magnetic
                                                                  Mueller PR        iron oxide,
                                                                  Weissleder R      mangafodipir
                                                                                    trisodium

Liver tissue          Hepatic hemangioma      MRI                 Hahn PF           Using ultrasmall
characterization                              US                  Harisinghani M    superpara-magnetic
                                                                  Mueller PF        iron oxide
                                                                  O'Neill MJ        OR
                                                                  Saini S           Gd-based chelates
                                                                  Weissleder R

Liver tissue          Hepatobiliary           MRI                 Hahn P            Using ultrasmall
characterization      disorders                                   Harisinghani M    superpara-magnetic
                                                                  Mueller P         iron oxide,
                                                                  Weissleder R      mangafodipir
                                                                                    trisodium

Liver tissue          Hepatocellular          MRI                 Hahn PF           Using ultrasmall
characterization      carcinoma                                   Harisinghani M    superpara-magnetic
                                                                  Mueller PR        iron oxide,
                                                                  Weissleder R      mangafodipir
                                                                                    trisodium

Liver tissue          Hepatocellular          MRI                 Hahn PF           Using combined
characterization      carcinoma                                   Halpern EF        ferrumoxide / Gd-
                                                                  Harisinghani M    DPTA
                                                                  Sahani D
Local uptake of       Neoplasm / primary      Nuclear medicine    Fischman AJ
specific tumor avid   and secondary
radiotracers
Lumen vascular        Arteriosclerosis /      CTA                 Gonzalez R
diameter              peripheral              MRA                 Hunter G
                                              Angiography         Lev M
                                                                  Waltman A
Macrophage content    Vulnerable plaque       Optical coherence   Weissleder R
                                              topography


Marrow edema          Bone fracture           MRI -T1            Palmer WE          Impact fractures
                                              Diffusion                             demonstrate
                                              weighted imaging                      prominent edema,
                                              / Apparent                            distraction
                                              diffusion constant                    fractures exhibit
                                                                                    minimal edema



Matrix                Neoplasm / primary      Optical             Ntziachristos V   Active, stable
metalloproteinase-2   and secondary                               Weissleder R      Fluorochromes
MMP-9
MMP-13

Mean transit time     Alzheimer's disease     SPECT               Harris G
(MTT)                                         fMRI                Gonzalez RG
                                                                  Sorensen AG
Mean transit time       Migraine              Diffusion / perfusion Grant E
(MTT)                                         weighted imaging       Schaefer P
                                              fMRI                   Sorensen AG
                                                                     Rosen BR
Mean transit time       Stroke                MRI (combined          Harris G        MTT helps to stratify
(MTT)                                         Arterial spin labeling Hoge R          patients in clinical
                                              and Dynamic            Ostergaard L    trials
                                              susceptibility         Rosen B         MR perfusion
                                              contrast)              Sorensen AG     territory imaging
                                              CAPTIVE                Wald LL

Mediastinal nodal       Lung neoplasm /       PET                   Fischman AJ      Physiologic imaging
status                  primary and           MRI                   McLoud TC        with FDG or iron
                        secondary             CT                    Weissleder R     oxide particles in
                                                                                     NSCLC

Microarchitecture       Osteoporosis          Digital radiographs   Rosenthal DI     Fine element
deterioration                                 3D microMRI                            modeling (FEM) to
                                              3D microCT                             predict mechanical
                                                                                     properties

Micro-architecture      Osteoporosis          Digital               Rosenthal DI     Fine element
deterioration                                 radiographs                            modeling (FEM) to
                                              3D microMRI                            predict
                                              3D microCT                             mechanical
                                                                                     properties
Microcalcifications     Breast neoplasm       Raman                 Feld MS (MIT)    Differential
                                              Spectroscopy                           diagnosis of benign
                                                                                     from malignant
                                                                                     microcalcifications


Microvascular blood     Breast neoplasm       US                    O'Neill MJ       Microbubble
volume                                                                               contrast agents
Microvascular blood     CNS neoplasm /        fMRI                  Belliveau
volume and              primary and           MRI                   Kennedy D
microvascular density   secondary                                   Rosen BR

Microvascular           Breast neoplasm       US                    O'Neill MJ       Microbubble
density                                                                              contrast agents
Microvessel density     Breast neoplasm       MRI                   Kopans DB        Magnetic
(MVD)                                                                                susceptibility-based
                                                                                     contrast agent OR
                                                                                     GD-DTPA with
                                                                                     dynamic echo planar
                                                                                     imaging

MR cholangio-           Calculus disease      MRI                   Sahani D
pancreatography                                                     Prasad S
MR cholangio-           Biliary stricture     MRI                   Prasad S
pancreatography                                                     Sahani D
MS plaque               Multiple sclerosis    MRI                   Jenkins B
demylination                                                        Rosen BR
                                                                    Stufflebeam SM
Musculoskeletal blood   Skeletal muscle injury PET                  Alpert NM        Animal study Use
flow                    and repair                                  Fischman AJ      of H2(15)O to study
                                                                                     muscle metabolism

Myocardial blood flow   Coronary artery       Nuclear medicine      Fischman A
via 13N-ammonia         disease               SPECT
Myocardial blood flow   Ischemic heart disease Nuclear medicine    Fischman A
via 13N-ammonia                                SPECT

Myocardial               Coronary artery       MRI                 Brady T
contractility / function disease               Nuclear Medicine    Fischman A

Myocardial function     Myocarditis            Nuclear medicine    Fischman A
contractility




Myocardial function     Myocarditis            MRI                 Brady T
contractility




Myocardial perfusion    Coronary artery        Nuclear medicine    Fischman A
                        disease

Myoinositol             Alzheimer's disease    MRS                 Gonzalez RG
N-acetylaspartate                                                  Jenkins B
(NAA)
Myoinositol (MI)        CNS AIDS /             MRS                 Gonzalez R
                        neuroinflammation                          Schaefer P
                        neurodegeneration                          Schwamm LH
N-acetylaspartate       Hodgkin's disease      MRS                 Jenkins B
(NAA)                                                              Kennedy D
                                                                   Rosas D
                                                                   Rosen BR
N-acetylaspartate       CNS AIDS /             MRS                 Gonzalez R
(NAA)                   neuroinflammation                          Schaefer P
                        neurodegeneration                          Schwamm LH
N-acetylaspartate       Hepatic                MRS                 Grant E
(NAA)                   encephalopathy                             Jenkins BG
                                                                   Schaefer P
N-acetylaspartate       CNS neoplasm /         MRS                 Gonzalez R     Metabolism, tumor
(NAA)                   primary and                                Husiman TA     viability and
                        secondary                                  Sorensen AG    response to therapy

N-acetylaspartate       Huntington's disease   MRS                 Jenkins BG
(NAA)                                                              Rosen B
N-acetylaspartate       Alzheimer's disease    MRS                 Gonzalez RG
(NAA)                                                              Jenkins B
N-acetylaspartate       Brain function /       MRI chemical shift  Gonzalez RG
(NAA) Images            neuronal content       Echo-planar imaging Jenkins B
                                               (EPI)               Rosen B
N-acetylaspartate      Epilepsy                MRS                 Jenkins BG
(NAA) lateralization
N-acetylaspartate      Parkinson’s disease     MRS                 Gonzales RG
(NAA) levels over time                                             Jenkins BG

Negative defect         Bone fracture          Plain radiographs   Palmer W
                                                                   Rosenthal DI
Neural activation of    Schizophrenia          PET                 Alpert N       Regional activation
dorsolateral pre-                                                  Fischman A     during cognitive
frontal cortex,                                                    Heckers S      paradigms
hippocampus and                                                    Rauch SL
cerebellum                                                         Schaefer P
Neuritic (senile)       Alzheimer's disease     In vivo multiphoton   Hyman B         Can use
plaque                                          microscopy                            histochemical or
                                                                                      immuno-
                                                                                      fluorescence for
                                                                                      amyloid B
Neuronal activation     Visual process          fMRI                  Mandeville JB
                        disorders                                     Rosen B
                                                                      Tootell RBH
Neuronal activation     Stroke                  fMRI                  Boas D          NIRS agrees well
                                                Diffuse optical       Mandeville JB   with fMRI, useful in
                                                topography (Near      Strangman G     longitudinal studies
                                                infrared
                                                spectroscopy)
Neuronal activation     Stroke                  Arterial spin labeling Wald LL
CMRO2                                           MRI
                                                O2 15 PET
                                                Xenon Enhanced CT

Neuronal injury         Alzheimer's disease     MRI                   Gonzalez RG

Opacities               Respiratory syncytial   CT                    McLoud TC
                        virus                                         Shepard J
Osseous bridging        Bone fracture /         Plain radiographs     Palmer W
                        healing                 MRI                   Rosenthal DI
                                                CT
Osteoblastic activity   Bone fracture /         Nuclear medicine      Fischman AJ
                        healing
Osteoblastic activity   Osseous neoplasm /      Nuclear medicine      Fischman A
                        primary and
                        secondary
Osteoblastic activity   Osteoarthritis          Nuclear medicine      Fischman AJ

Osteoblastic activity   Osteomyelytis           Nuclear medicine      Fischman AJ     Uptake of bone-
                                                                                      seeking radio-
                                                                                      pharmaceuticals
Osteoblastic activity   Soft tissue infection   Nuclear medicine      Fischman AJ


Osteochondral lesions Joint injury / general    MR arthrography       Palmer WE       Assesses the
                                                                                      stability of lesions
Oxygen consumption      Brain development       Optical Imaging       Boas D          Diffuse optical
                                                                      Dunn A          imaging (DOI)
Oxygen consumption      CNS neoplasm /          Optical               Boas D          Diffuse Optical
                        primary and                                   Dunn A          imagine (DOI)
                        secondary, presence
                        and viability

Oxygen consumption      Stroke                  Optical imaging       Boas, D
                                                                      Dunn, A
                                                                      Lo E
Oxygen utilization      Alzheimer's disease Optical                   Boas D          Combining of
                                                                      Dunn A          multi-wavelength
                                                                                      and laser speckle
                                                                                      contrast imaging


Partial thickness and   Elbow injury /          MR arthrography       Palmer WE       Distinguishes
full thickness tears    collateral ligament                                           thickness of tears
Perfusion / diffusion   Myocarditis            MRI                 Brady T




Perfusion / diffusion   Myocarditis            Nuclear medicine    Fischman A




Perianeurysmal          Inflammatory          CT                   Brady T
fibrosis                abdominal aortic                           Saini S
                        aneurysm (IAAA)                            Waltman A
Periarticular erosion   Amyloid arthropathy / Plain radiographs    Palmer W
                        crystalline disease   MRI                  Rosenthal DI

Periarticular erosion   Arthritis /            Plain radiographs   Palmer W
                        inflammatory           MRI                 Rosenthal DI
Periarticular erosion   Arthritis / septic     Plain radiographs   Palmer W
                                               MRI                 Rosenthal DI

Periarticular erosion   Pigmented villonodular Plain radiographs   Palmer W
                        synovitis              MRI                 Rosenthal DI

Periarticular erosion   Synovial               Plain radiographs   Palmer W
                        chondromatosis         MRI                 Rosenthal DI

Peri-intestinal         Inflammatory bowl      MRI                 Hahn P         Tissue FISP pulse
inflammation            disease                                                   sequence
                        (IBD)
Peri-rectal fat         Rectal carcinoma /     MRI                 Hahn P         Predictor of high
involvement             recurrent                                  Prasad S       probability of local
                                                                   Saini S        recurrence
Permeability surface    Pulmonary neoplasm     PET                 Fischman AJ
area product                                   MRI                 McLoud TC

Pharmacokinetics        Neoplasm / primary     SPECT               Fischman AJ    Additional use for
Biodistribution         and secondary          PET                 Jenkins B      determining in vivo
Non-tumor uptake                               MRS                                heterogeneity of
                                                                                  tumor uptake

Phosphocreatine         CNS neoplasm /         MRS                 Gonzalez R     Metabolism, tumor
                        primary and                                Husiman TA     viability and
                        secondary                                  Sorensen AG    response to therapy

Plaque Type             Vulnerable plaque      Optical coherence   Weissleder R
                                               topography


Portal Venous invasion Pancreatic carcinoma    MRA                 Halpern EF     Better predictor
                                                                   Saini S        than conventional
                                                                   Waltman AC     angiography
Presence of             Breast neoplasm        MRI                 Kopans DB      4 of 17 patients
contralateral                                                                     (24%) had
synchronous cancers                                                               contralateral cancer
                                                                                  occult to physical
                                                                                  exam,
                                                                                  mammography and
                                                                                  US
Prostate volume        Benign prostatic         US                   Hahn PF
                       hypertrophy              CT                   Mueller PR
                                                MRI                  O’Neill MJ
Prostate volume        Prostate cancer          US                   Hahn PF
                                                CT                   Mueller PR
                                                MRI                  O'Neill MJ
Prostate-specific      Prostate cancer          Optical              Ntziachristos V   Active, stable
antigens (PSA)                                                       Weissleder R      Fluorochromes
Pulmonary              Alveolar pulmonary     CT                     McLoud T
consolidation          edema                  MRI                    Shepard J
Pulmonary              Aveolar bronchial cell CT                     McLoud TC
consolidation          carcinoma              MRI                    Shepard J
Pulmonary              Pneumonitis            CT                     McLoud TC
consolidation                                 MRI                    Shepard J
                                              Plain radiographs
Pulmonary              Pneumonitis            CT                     McLoud TC
consolidation                                 MRI                    Shepard J
rCMRO2                 Brain function / drugs fMRI                   Jenkins B         Response to stimuli
                       of abuse                                      Kosofsky B
                                                                     Mandeville JB
                                                                     Rosen B
Regional blood flow    Breast neoplasm          MRI                  Kopans DB         Magnetic
and blood volume                                                                       susceptibility-based
                                                                                       contrast agent OR
                                                                                       GD-DTPA with
                                                                                       dynamic echo planar
                                                                                       imaging

Relative % contrast    Adrenal neoplasm         CT                   Boland GW         Differential
washout                                                              Hahn PF           diagnosis of adrenal
                                                                     Mueller PR        masses
Relative cerebral blood Anorexia                PET                  Alpert N
flow (rCBF)                                                          Fischman A
                                                                     Rauch SL
Relative cerebral blood Brain function /        Pharmacologic MRI    Bogdanov M        Using D-
flow (rCBF)             mapping -               PET                  Chen YC           amphetamine and
                        dopaminergic            fMRI                 Jenkins B         CFT
                        neurotransmitter                             Rosen B
                        activity
Relative cerebral blood Stroke                  Diffusion weighted Kennedy D
flow index (rCBF)                               imaging            Lo E
                                                fMRI               Rosen B
                                                MRI (morphometry)

Relative cerebral blood Stroke / ischemic       CAPTIVE MRI          Bogdanov A
volume (rCBV)                                                        Jenkins B
                                                                     Kwong K
                                                                     Weissleder R
Relative cerebral blood Brain function /        Pharmacologic MRI    Bogdanov M        Using D-
volume (rCBV)           mapping -               PET                  Chen YC           amphetamine and
                        dopaminergic            fMRI                 Jenkins B         CFT
                        neurotransmitter                             Rosen B
                        activity
Relative cerebral blood Hypertension            Dynamic              Hunter G          Using Gd-DTPA
volume (rCBV)                                   susceptibility       Rosen B           following L-arginine
                                                contrast MRI                           infusion

Restricted diffusion   Abscess                  Diffusion weighted   Grant E
                                                imaging              Gonzalez RG
                                                                     Schaefer P
Restricted diffusion Infectious disease /        Diffusion weighted   Grant, E
                     -empyema                    imaging              Schaefer P
                     -herpes virus
                     -CJD
Restricted diffusion Migraine                    Optical              Boas D
                                                                      Dunn A
Restricted water        Brain injury             Diffusion weighted   Huisman TA        Cytotoxic edema,
mobility                                         imaging              Gonzalez RG       vasogenic edema
                                                 Apparent diffusion   Schaefer P        and diffuse axonal
                                                 constant             Sorensen AG       injury
Right posterior hepatic Cirrhosis                MRI                  Hahn PF           Discrimination of
notch                                            CT                   Sahani D          alcohol from virus-
                                                                                        induced cirrhosis
ROC curve analysis of Ovarian neoplasm /         CT                   O'Neill MJ        Predictive model of
13 CT radiographic    presence and viability                                            relative success of
parameters                                                                              surgical
                                                                                        cytoreduction

Seizure focus           Epilepsy                 MEG / EEG            Halgren E
                                                                      Stufflebeam SM
Soft tissue             Myopathy                 MRI                  Palmer W
inflammation                                                          Rosenthal DI




Soft tissue             Neoplasm / primary       Nuclear medicine     Fischman AJ
inflammation            and secondary            MRI                  Palmer WE
                                                                      Rosenthal DI
Soft tissue             Soft tissue infection    MRI                  Fischman AJ
inflammation                                     Nuclear medicine     Palmer W
                                                                      Rosenthal DI
Soft tissue             Trauma                   MRI                  Palmer W
inflammation                                                          Rosenthal DI
Soft tissue             Trauma                   Nuclear medicine     Fischman AJ
inflammation
Soft tissue             Simple renal cysts       US                   Mueller PR
inflammation                                     CT
                                                 MRI
Soft tissue uptake of Trauma                     Nuclear medicine     Fischman AJ
radiotracers
Somatostatin receptor Neoplasm / primary         Optical              Ntziachristos V   Targeted
                      and secondary                                   Weissleder R      Fluorochromes

Spatial cartilage       Joint injury / hip and   Co-planar MRI        Palmer WE         MR using fat-
thickness               knee                                          Rosenberg AE      saturated 3D spoiled
                                                                      Rosenthal DI      gradient-echo
                                                                                        images (SPGR)

Specific regional       Schizophrenia            fMRI                 Kuperberg G       Regional activation
uptake, target                                                        Manoach D         during cognitive
selection and                                                         Stufflebeam SM    paradigms
functional activation                                                 Rosen B

Spermine levels         Prostate cancer          MRS magic angle      Cheng LL          Proposed
                                                 spinning             Gonzalez RG       endogenous
                                                                                        inhibitor of prostate
                                                                                        CA growth

Spiculated lymph node Rectal carcinoma /         MRI                  Hahn P            Predictor of high
                      recurrent                                       Prasad S          probability of local
                                                                      Saini S           recurrence
Splenic tissue          Splenic cysts         MRI                 Hahn PF          Using ultrasmall
characterization                                                  Harisinghani M   superpara-magnetic
                                                                  Mueller PR       iron oxide
                                                                  Weissleder R
Splenic tissue          Splenic neoplasm      MRI                 Hahn PF          Using ultrasmall
characterization                                                  Harisinghani M   superpara-magnetic
                                                                  Mueller PR       iron oxide
                                                                  Weissleder R
Splenic tissue          Splenic trauma        MRI                 Harisinghani M   Using ultrasmall
characterization                                                  Weissleder R     superpara-magnetic
                                                                                   iron oxide

Subendothelial lipid    Vulnerable plaque     Optical coherence   Brady T
pool                                          topography          Muller J
                                              Near infrared
                                              spectroscopy
Synovial thickening     Arthritis /           MRI                 Palmer W
                        inflammatory                              Rosenthal DI
Synovial thickening     Arthritis / septic    Plain radiographs   Palmer W
                                              MRI                 Rosenthal DI

Synovial thickening     Pigmented villonodular MRI                Palmer W
                        synovitis                                 Rosenthal DI

Targeted cellular and   CNS neoplasm /        Optical             Kwong KK         Exogenous contrast
molecular probes        primary and           MRI                 Weissleder R     agents
                        secondary, presence   PET                                  Animal models
                        and viability

Targeted                Vulnerable plaque     Contrast            O'Neill MJ
mircobubble                                   enhanced US         Waltman A
contrast agents

Thalamic neuronal loss Multiple sclerosis     MRI                 Gonzalez RG
                                              fMRI                Fischl B
                                              MRS                 Kuperberg G
Thalamus and            Encephalitis / west   MRI                 Gonzalez RG      Disease
substantia nigra        nile virus                                Sorensen AG      confirmation and
hyperintensities                                                                   progression
                                                                                   monitoring

Thickness and         Vulnerable plaque       Intravascular US    Brady T
composition of plaque                         IVUS                Lev M
                                                                  O'Neill NJ
                                                                  Waltman A
Tissue characterization Osseous neoplasm /    CT                  Rosenthal DI
                        primary and           MRI
                        secondary
Tissue characterization Multiple sclerosis    fMRI                Fischl B
                                              MRI morphometry     Kuperberg G

Trabecular pore size Osteoporosis             MRI                 Rosenthal DI


Tumor angiogenesis      CNS neoplasm /        MRI                 Davis T          Measured by
                        primary and           MRS                 Rosen B          dynamic
                        secondary             MRA                 Wald LL          susceptibility
                                                                  Weissleder R     contrast (DSC) and
                                                                                   monocrystalline iron
                                                                                   oxide nanoparticles
                                                                                   (MION)
Tumor angiogenesis      Glioma               MRI                    Davis T        Measured by
                                             MRS                    Rosen B        dynamic
                                             MRA                    Wald LL        susceptibility
                                                                    Weissleder R   contrast (DSC) and
                                                                                   monocrystalline iron
                                                                                   oxide nanoparticles
                                                                                   (MION)


Tumor angiogenesis      Neoplasm / primary   MRI Dynamic            Bogdanov A     High resolution MR
                        and secondary        susceptibility         Bremer C       using long
                                             contrast (DSC) /       Rosen BR       circulating iron
                                             monocrystalline iron   Weissleder R   oxide contrast
                                             oxide nanoparticles                   agents
                                             (MION)                                Rodent model

Tumor angiogenesis      Neoplasm / primary   MRI                    Bogdanov A     Animal model using
Macromolecular          and secondary        SPECT                  Weissleder R   pegylated DOTA
contrast extravasate                                                               derivatized graft
                                                                                   copolymers

Tumor associated        Breast neoplasm      Optical                Bremer C       Expression levels of
enzymatic activity                           Near infrared          Bogdanov A     cathepsin-B activity
                                             spectroscopy           Weissleder R   in animal models of
                                                                                   breast cancer

Tumor growth rate       CNS neoplasm /       MRI                    Bogdanov A     Serial studies of
                        primary and                                 Weissleder R   tumor volume using
                        secondary                                                  uptake of long-
                                                                                   circulating dextrin
                                                                                   coated iron oxide
                                                                                   (LCDIO)
                                                                                   Rodent model

Tumor growth rate       CNS Neoplasm /       MRI                    Tang Y         Transgenic murine
                        schwannoma and                              Weissleder R   models of
                        neurofibromatosis                                          neurofibromatosis
Tumor growth rate       Neoplasm / primary   MRI                    Bogdanov A     SPECT via uptake of
                        and secondary        SPECT                  Kwong K        long-circulating
                                             Dual tracer NMR        Weissleder R   dextrin coated iron
                                                                                   oxide
                                                                                   (LCDIO)
                                                                                   Rodent model
Tumor margin            Glioma               MRI                    Weissleder R   Via ultra small
                                                                                   particulate iron
                                                                                   oxide (USPIO)
Tumor mass              Neoplasm / primary   Optical                Weissleder R
                        and secondary

Tumor volume            Breast neoplasm      MRI                    Harris G

Tumoral proteinase      Neoplasm / primary   Optical                Bogdanov A     Rodent model
                        and secondary        Near infrared          Mahmood U
                                             spectroscopy           Weissleder R
Vascular architecture   Hepatic neoplasm /   Multidector CT         Hahn PF        Presurgical
                        primary and          angiography            Mueller PR     treatment planning
                        secondary            (MDCTA)                Saini S
                                                                    Sahani D
Vascular diameter and Iliac aneurysm         US                     Waltman A
circumference                                CT
                                             MRI
Vascular diameter and Aortic aneurysm         US                  Waltman A
circumference                                 CT
                                              MRI
Vascular involvement   Pancreatic carcinoma   MRA                 Halpern EF      Better predictor
                                                                  Saini S         than conventional
                                                                  Waltman AC      angiography
Vascular lumen         Arteriosclerosis /     CTA                 Gonzalez R
diameter               central                MRA                 Hunter G
                                              Angiography         Lev M
                                                                  Waltman A
Vascular lumen         Dissection /           CT                  Waltman A
diameter               peripheral             MRI
                                              Angiography
Vascular occlusion     Stroke / ischemic      Diffusion / perfusion Gonzalez R
                                              weighted imaging      Harris G
                                              MRI                   Sorensen AG
                                              CT perfusion
                                              CTA

Vascular volume        Glioma                 Optical             Weissleder
fraction

Vascular volume         Sarcoma               Optical             Weissleder R
fraction
Ventilation / perfusion Pulmonary embolism    Nuclear medicine    Fischman A
mismatch
Water content           Bone fracture         MRI -T1            Palmer WE        Impact fractures
                                              Diffusion                           demonstrate
                                              weighted imaging                    prominent edema,
                                              / Apparent                          distraction
                                              diffusion constant                  fractures exhibit
                                                                                  minimal edema



Water EF               Stroke / ischemic      CAPTIVE MRI     Bogdanov A
                                                              Jenkins B
                                                              Kwong K
                                                              Weissleder R
Whole brain            Obsessive compulsive MRI (morphometry) Kennedy D           Findings include sig.
morphometry            disorder                               Rosen BR            less total white-
                                                                                  matter and greater
                                                                                  cortex and opercular
                                                                                  volumes
Disease
Category
Oncology /
Neoplasm
Gastrointestinal
Oncology /
Neoplasm
Gastrointestinal
Oncology /
Neoplasm
Inflammatory



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Musculoskeletal




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Musculoskeletal



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Musculoskeletal



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Neurological




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Oncology /
Neoplasm

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    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                   12/11/2011
                         Disease /
                         Medical                  Imaging
Biomarker*               condition                Technique          Investigators     Comments
18 F-fluorodeoxy-        Pancreatic carcinoma     PET                Fischman AJ
glucose

99mTc labeled            Colorectal carcinoma     SPECT              Fischman AJ       Phase III clinical
monoclonal antibody                                                                    trial with
                                                                                       HumaSPECT-Tc
Abnormal lymphatic       Lymphatic extension      MRI                Hahn PF           MR Lymphangio-
uptake of tracer         of pelvic malignancy                        Harisinghani M    graphy using
                         (gynecological                              Mueller PR        ultrasmall superpara-
                         oncology)                                   Saini S           magnetic iron oxide
                                                                     Weissleder R

ACCD activation          Attention deficit        fMRI               Bush G
(anterior cingulate      hyperactivity disorder   PET                Fischman A
cortex division)         (ADHD)                                      Rosen B
Acinar cell receptor     Pancreatic function      MRI                Brady TJ          Secretin
binding                                                              Shen TT           monocrystalline iron
                                                                     Weissleder R      oxide nanoparticles
                                                                                       (MION)

Acute bronchial          Respiratory syncytial    CT                 McLoud TC
dilatation               virus                                       Shepard J
Wall thickening
Altered vascular and     Asphyxia                 CT                 Gonzalez RG
tissue permeability                                                  Grant E

Anatomic disruption of Aortic dissection          US                 Gonzalez R
arterial wall                                     CT                 Waltman A
                                                  MRI
                                                  Angiography
Anatomic disruption of Carotid dissection         US                 Gonzalez R
arterial wall                                     CT / CTA           Waltman A
                                                  MRI / MRA
                                                  Angiography
Anatomic disruption of Intracranial arterial      CTA                Gonzalez R
arterial wall          dissection                 MRA                Lev MH
                                                  Angiography        Waltman A
Aneurysmal wall          Inflammatory             CT                 Brady T
thickness                abdominal aortic                            Saini S
                         aneurysm (IAAA)                             Waltman A
Angiogenesis             Breast neoplasm          US                 O'Neill MJ        Microbubble
                                                                                       contrast agents
Anterior cingulate size Alzheimer's disease       MRI                Hyman B           Can distinguish
and thickness                                                                          normal from mild
                                                                                       AD with 93%
                                                                                       accuracy
Anti-tumor antibody      Neoplasm / primary       Optical            Ntziachristos V   Targeted
                         and secondary                               Weissleder R      Fluorochromes

Apoptosis                Neoplasm / primary       Optical            Ntziachristos V   Active, stable
Caspase-1                and secondary                               Weissleder R      Fluorochromes
Caspase-3
Apoptosis                Neoplasm / primary       Optical            Ntziachristos V   Active, stable
Phosphatidylserine       and secondary                               Weissleder R      Fluorochromes

Apparent diffusion       Stroke                   Diffusion weighted Kennedy D
constant (ADC)                                    imaging            Lo E
                                                  fMRI               Rosen B
                                                  MRI (morphometry)

Apparent diffusion       Neurodegenerative        fMRI               Jenkins BG
constant (ADC)           disorders                MRI / diffusion    Kennedy D
                                                  weighted imaging   Rosas HD
                                                                     Rosen B
Arterial calcification   Atherosclerosis /        CT                 Brady T
                         central


                                                            Page 45 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                12/11/2011
Arterial calcification    Arteriosclerosis /     CT                  Brady T
                          peripheral

Arterial calcification    Coronary artery        CT                  Brady T
                          disease

Articular cartilage and Cartilage                MRI                 Palmer WE       MR using fat-
subchondral bone        abnormalities                                                suppressed SPGR
thickness                                                                            images
Articular cartilage     Arthritis /              Plain radiographs   Palmer W
thickness               inflammatory             MRI                 Rosenthal DI
Articular cartilage     Arthritis / rheumatoid   Plain radiographs   Palmer W
thickness                                        MRI                 Rosenthal DI
Articular cartilage     Osteoarthritis           Plain radiographs   Palmer W
thickness                                        MRI                 Rosenthal DI
Articular cartilage     Joint injury / hip and   Co-planar MRI       Palmer WE       MR using fat-
volume                  knee                                         Rosenberg AE    saturated 3D spoiled
                                                                     Rosenthal DI    gradient-echo
                                                                                     images (SPGR)

Articular labrum       SLAP lesions of the       MR arthrography     Bencardino JT
fraying                shoulder                                      Palmer WE
Atherosclerotic plaque Vulnerable plaque         Thermography        Brady T
temperature                                                          Lev M
                                                                     Waltman A

Basal ganglia /           Huntington's disease   MRI                 Harris G
putamen volume
Bicep anchor avulsion     SLAP lesions of the    MR arthrography     Bencardino JT
                          shoulder                                   Palmer WE
Biliary ductal dilatation Biliary obstruction    US                  Hahn P
                                                 CT                  Mueller P
                                                 MRI
Biliary ductal dilatation Biliary parasitic      US                  Hahn P
                          disease                CT                  Mueller P
                                                 MRI                 O'Neill MJ
Biliary ductal dilatation Cholangitis            MRI                 Prasad S        MR cholangio-
                                                                     Sahani D        pancreatography

Biliary ductal dilatation Choledo-cholithiasis   US                  Hahn PF
                                                 CT                  O'Neill MJ
                                                 MRI                 Mueller P

Blood oxygen level        Neurodegenerative      fMRI                Jenkins BG
depletion                 disorders              MRI / diffusion     Kennedy D
                                                 weighted imaging    Rosas HD
                                                                     Rosen B
Blood oxygen level        Dementia               fMRI                Rosen B
depletion (BOLD)
Blood-tumor barrier       Glioma                 MRI                 Gonzalez RG
permeability (BTP)                               fMRI                Kwong KK
                                                                     Sorensen AG
                                                                     Weissleder R
Body fat composition      AIDS wasting           CT                  Rosenthal DI
                          syndrome




Body fat composition      Obesity                Quantitative CT     Rosenthal DI
                                                 MRI
                                                 US

Bone fill score and       Bone fracture /         US                 O'Neill MJ      Animal study
penetration depth         healing and distraction                                    Bone healing
                          osteogenesis wounds                                        assessed by
                                                                                     increased fill and
                                                                                     decreased
                                                                                     penetration depth




                                                           Page 46 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                  12/11/2011
Bone mineral density    Osteopenia            Plain radiographs     Rosenthal DI      Must establish bone
                                              Dual energy X-ray                       strength as well as
                                              absorptiometry                          density
                                              (DEXA)
                                              CT

Bone mineral density    Osteoporosis          Plain radiographs     Rosenthal DI      Must establish bone
                                              Dual energy X-ray                       strength as well as
                                              absorptiometry                          density
                                              (DEXA)
                                              CT

Bowel wall              Crohn's disease       MR enteroclysis       Hahn P            Use of experimental
differentiation                                                                       oral contrast Kaolin,
                                                                                      locus bean gum,
                                                                                      methylcellulose +
                                                                                      Barium

Bowel wall thickening   Inflammatory bowl     MRI                   Hahn P            Tissue FISP pulse
                        disease                                                       sequence
                        (IBD)
Cartilage thickness     Osteoarthritis        Intra-articular       Palmer WE
                                              Optical coherence
                                              topography
Cathepsin D             Neoplasm / primary    Optical               Ntziachristos V   Active, stable
                        and secondary                               Weissleder R      Fluorochromes

Caudate lobe            Cirrhosis             MRI                   Hahn PF           Discrimination of
enlargement                                   CT                    Sahani D          alcohol from virus-
                                                                                      induced cirrhosis
Cerebral blood flow     Alzheimer's disease   Perfusion weighted    Hoge R
                                              imaging / Arterial
                                              spin labeling

Cerebral blood flow     Alzheimer's disease   Optical               Boas D            Combining of multi-
(CBF)                                                               Dunn A            wavelength and
                                                                                      laser speckle
                                                                                      contrast imaging
Cerebral blood flow     Brain function        MRI                   Belliveau         Response to stimuli
(CBF )                                        fMRI                  Kwong K
                                              PET                   Rosen BR
Cerebral blood flow     Brain development     Optical Imaging       Boas D            Diffuse optical
(CBF)                                                               Dunn A            imaging (DOI)
Cerebral blood flow     CNS neoplasm /        Optical               Boas D            Diffuse optical
(CBF)                   primary and                                 Dunn A            imagine (DOI)
                        secondary, presence
                        and viability

Cerebral blood flow     Dementia              MRI / arterial spin   Hoge R
(CBF)                                         labeling
Cerebral blood flow     Epilepsy              MRI / arterial spin   Hoge R
(CBF)                                         labeling              Kwong KK
Cerebral blood flow     Migraine              Laser speckle         Boas D
(CBF)                                         contrast imaging      Bolay
                                              Diffuse optical       Dunn A
                                              topography
Cerebral Blood flow     Stroke                Optical imaging       Boas, D
(CBF)                                                               Dunn, A
                                                                    Lo E
Cerebral blood flow     Schizophrenia         PET                   Alpert N          Regional activation
(CBF)                                                               Fischman A        during cognitive
                                                                    Heckers S         paradigms
                                                                    Rauch SL
                                                                    Schaefer P
Cerebral blood flow     Parkinson’s disease   MRI / Arterial spin   Hoge R
(CBF)                                         labeling
Cerebral blood flow     Glioma                MRI                   Gonzalez RG
(CBF)                                         fMRI                  Sorensen AG
                                                                    Rosen B



                                                         Page 47 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                   12/11/2011
Cerebral blood flow      Migraine               Diffusion / perfusion Grant E
(CBF)                                           weighted imaging       Schaefer P
                                                fMRI                   Sorensen AG
                                                                       Rosen BR
Cerebral blood flow      Alzheimer's disease    SPECT                  Harris G
(CBF)                                           fMRI                   Gonzalez RG
                                                                       Sorensen AG
Cerebral blood flow      Stroke                 MRI (combined          Harris G       MTT helps to stratify
(CBF)                                           Arterial spin labeling Hoge R         patients in clinical
                                                and Dynamic            Ostergaard L   trials
                                                susceptibility         Rosen B        MR perfusion
                                                contrast)              Sorensen AG    territory imaging
                                                CAPTIVE                Wald LL

Cerebral blood flow      Stroke / ischemic      CAPTIVE MRI         Bogdanov A
(CBF)                                                               Jenkins B
                                                                    Kwong K
                                                                    Weissleder R
Cerebral blood volume Brain function / drugs fMRI                   Jenkins B         Response to stimuli
(CBV)                 of abuse                                      Kosofsky B
                                                                    Mandeville JB
                                                                    Rosen B
Cerebral blood volume Stroke                 MRI (combined          Harris G          MTT helps to stratify
(CBV)                                        Arterial spin labeling Hoge R            patients in clinical
                                             and Dynamic            Ostergaard L      trials
                                             susceptibility         Rosen B           MR perfusion
                                             contrast)              Sorensen AG       territory imaging
                                             CAPTIVE                Wald LL

Cerebral blood volume Glioma                    MRI                   Gonzalez RG
(CBV)                                           fMRI                  Sorensen AG
                                                                      Rosen B
Cerebral blood volume Alzheimer's disease       SPECT                 Harris G
(CBV)                                           fMRI                  Gonzalez RG
                                                                      Sorensen AG
Cerebral blood volume Parkinson’s disease       MRI / Arterial spin   Hoge R
(CBV)                                           labeling

Cerebral blood volume Migraine                  Diffusion / perfusion Grant E
(CBV)                                           weighted imaging      Schaefer P
                                                fMRI                  Sorensen AG
                                                                      Rosen BR
Change in local tissue   Neoplasm / primary     CT                    Palmer WE       Mutlicenter Trail
density or contrast      and secondary          MRI                   Rosenthal DI    with 367 patients -
enhancement                                                                           CT and MRI equally
                                                                                      reliable for diagnosis

Chemotactic peptide      Pancreatitis           SPECT                 Fischman AJ     Via 99mTc labeled
uptake                                                                                peptide analog




Choline                  CNS AIDS /             MRS                   Gonzalez R
                         neuroinflammation                            Schaefer P
                         neurodegeneration                            Schwamm LH
Choline                  Hepatic                MRS                   Grant E
                         encephalopathy                               Jenkins BG
                                                                      Schaefer P
Choline                  CNS neoplasm /         MRS                   Gonzalez R      Metabolism, tumor
                         primary and                                  Husiman TA      viability and
                         secondary                                    Sorensen AG     response to therapy

Choline / sodium (NA) Multiple sclerosis        MRS                   Jenkins B
ratio                                                                 Gonzalez RG
Creatine / sodium
(NA) ratio
Choline : creatine ratio Huntington's disease   MRS                   Jenkins BG
                                                                      Rosen B




                                                           Page 48 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                              12/11/2011
CMRO2                    Stroke                 fMRI               Boas D          NIRS agrees well
                                                Diffuse optical    Mandeville JB   with fMRI, useful in
                                                topography (Near   Strangman G     longitudinal studies
                                                infrared
                                                spectroscopy)
Comparative              Multiple sclerosis     MRI             Jenkins B
brainstem analysis                                              Rosen BR
                                                                Stufflebeam SM
Contrast enhanced       Pancreatic mass      MRI cholangio -    Prasad S
tissue characterization                      pancreatography    Sahani D
                                                                Saini S
Cortical thickness      Schizophrenia        MRI (morphometry) Fischl B
                                                                Harris G
                                                                Kennedy D
                                                                Kuperberg G
Cortical activation     Obsessive compulsive fMRI               Fischman A
during provoked         disorder             PET                Rauch SL
conditions                                   SPECT              Rosen BR
Cortical activation     Stroke / recovery    fMRI               Schaechter J
during sensorimotor                                             Rosen BR
tasks
Cortical activity       Pain                 fMRI               Fischman A
                                             PET                Halgren E
                                             SPECT              Rosen B
                                             MEG                Sorensen AG
                                                                Stuffelbeam SM
Cortical dysplasia      Epilepsy             MRI / MEG          Dale A
                                             fMRI               Grant E
                                                                Mandeville J
                                                                Rosen B
                                                                Stufflebeam SM
                                                                Wald LL
Cortical spreading      Migraine             Blood oxygen level Hadjikhani N       Signal changes
depression (CSD)                             dependent (BOLD)   Rosen BR           measured during
                                             fMRI               Sorensen AG        visual aura
Cortical surface        Bone fracture        Plain radiographs  Palmer W
disruption                                                      Rosenthal DI
Cortical thickness      Huntington's disease fMRI               Dale A
                                             MRI morphometry    Fischl B
                                                                Harris G
                                                                Kennedy D
                                                                Rosas D
Cortical thickness      Multiple sclerosis   fMRI               Fischl B
                                             MRI morphometry    Kuperberg G

Cortical thickness       Obsessive compulsive MRI (morphometry) Kennedy D
                         disorder

Cortical thickness and Attention deficit        MRI (morphometry) Kennedy D
asymmetry              hyperactivity disorder
                       (ADHD)
Cortical thickness,    Brain development /      MRI morphometry    Caviness VS
volume and location    -anencephaly             fMRI               Dale A
                       -microcephaly                               Fischl B
                       -holoprosencephaly                          Kennedy D

Cyst composition /      Intra-abdominal         US                 Mueller P
tissue characterization abscess                 CT
                                                MRI
Cyst composition /      Arthritis / septic      PET                Palmer W
tissue characterization                                            Rosenthal DI

Cyst composition /      Fibrocystic change      US                 Kopans DB
tissue characterization                         CT
                                                MRI
Cyst composition /      Ganglion cyst           US                 Rosenthal DI
tissue characterization                         CT
                                                MRI




                                                         Page 49 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                               12/11/2011
Cyst composition /      Renal neoplasm /        US                   Mueller PR
tissue characterization primary and             CT
                        secondary               MRI
Cyst composition /      Synovial cell sarcoma   US                   Rosenthal DI
tissue characterization                         CT
                                                MRI
Cyst composition /      Simple renal cysts      US                   Mueller PR
tissue characterization                         CT
Soft tissue                                     MRI
inflammation

Cystic architecture /   Synovial cyst           US                   Palmer W
tissue characterization                         CT                   Rosenthal DI
                                                MRI
Cystic nodal             Thyroid carcinoma      US                   Hahn PF
metastases                                                           Harisinghani M
                                                                     Mueller PR
                                                                     O'Neill MJ
Decreased N-          Multiple sclerosis        MRS                  Jenkins B
acetylaspartate (NAA)                                                Gonzalez RG

Decreased regional       Renal disease          PET                Alpert NM
blood flow                                                         Fischman AJ
Degree of                Pancreatic adrenal     Multidetector CT   Boland GW
circumferential vessel   carcinoma              angiography (MDCT) Mueller PR
involvement                                     / CTA              Saini S
Diffuse cerebral         Cerebral malaria       CT                 Gonzalez RG
edema with thalamic
+/- cerebellar hypo-
attenuation

Diffuse cerebral         Infectious disease /   CT                   Gonzalez RG
edema with thalamic      cerebral malaria
+/- cerebellar hypo-
attenuation

Directed molecular       HIV                    MRI                  Weissleder R
probes                                          PET
                                                Optical
Directed molecular       Huntington's disease   MRI                  Fischman A
probes                                          PET                  Weissleder R
                                                Optical
Directed molecular       Neoplasm / primary     MRI                  Fischman AJ
probes                   and secondary          PET                  Hunter GJ
                                                Optical              Weissleder R
Directed molecular       Parkinson’s disease    PET                  Weissleder R
probes                                          Optical
Directed molecular       Alzheimer's disease    PET                  Fischman A       Animal modeling
probes                                          SPECT                Weissleder R     Optical with
                                                Optical                               exogenous contrast
                                                                                      agents
Directed molecular     Diabetes                 MRI                  Moore A
probes for beta cell                                                 Bogdanov AJ
mass                                                                 Weissleder R
Distribution and       Rotator cuff injury      MR arthrography      Palmer WE        Distinguishes full
leakage of intra-                                                                     from partial
articular administered                                                                thickness tears
contrast media

Dopa decarboxylase       Dyskinesia (PNKD)      PET                  Fischman A
activity

Dopamine binding         Parkinson’s disease    SPECT (using I-123   Fischman A
potential                                       altropane)           Halpern E
                                                                     Sahani D
Dopamine transporter Parkinson’s disease        SPECT (using I-123   Fischman A
(DAT) density                                   altropane)           Halpern E
                                                                     Sahani D




                                                          Page 50 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                          12/11/2011
Dopamine transporter Attention deficit             SPECT                    Fischman A
density              hyperactivity disorder                                 Rauch SL
                     (ADHD)
Dopaminergic         Parkinson’s disease           fMRI                     Fishman A         Pet using 11C-CRT
neurotransmitter                                   PET                      Livni E
activity                                                                    Rosen B

Ductal dilatation        Cholangitis               MRI                      Prasad S          MR cholangio-
                                                                            Sahani D          pancreatography

Ductal irregularity or   Pancreatitis              MRI                      Prasad S          Visualized by MR
obstruction                                                                 Sahani D          cholanio-
                                                                            Saini S           pancreatography
                                                                                              (MRCP)

Early diffusion          Asphyxia                  Diffusion weighted       Grant E
changes                                            imaging                  Schaefer P
                                                                            Sorensen AG
Edema / change in        Trauma                    MRI                      Palmer W
signal intensity and                               Diffusion weighted       Rosenthal DI
apparent diffusion                                 imaging
constant
Embolism volume          Pulmonary embolism        MRI                      Weissleder R      Via monocrystalline
                                                                                              iron oxide
                                                                                              nanoparticles
                                                                                              (MION)

Entorhinal cortex        Alzheimer's disease       MRI                      Hyman B           Can distinguish
                                                                                              normal from mild
                                                                                              AD with 93%
                                                                                              accuracy
Enzymatic activity       Neoplasm / primary        Optical                  Weissleder R      Rodent model
                         and secondary

Fibrillations            Osteoarthritis            Intra-articular          Palmer WE
                                                   Optical coherence
                                                   topography
Fibrosis                 Osteoarthritis            Intra-articular          Palmer WE
                                                   Optical coherence
                                                   topography
Fibrous cap thickness    Vulnerable plaque         Optical coherence        Weissleder R
                                                   topography


Flow heterogeneity       Stroke                    MRI (combined            Harris G          MTT helps to stratify
(FH)                                               Arterial spin labeling   Hoge R            patients in clinical
                                                   and Dynamic              Ostergaard L      trials
                                                   susceptibility           Rosen B           MR perfusion
                                                   contrast)                Sorensen AG       territory imaging
                                                   CAPTIVE                  Wald LL

Fluorescent proteins / Neoplasm / primary          Macroscopic              Ntziachristos V   Green fluorescence
exogenous              and secondary               fluorescence             Weissleder R      proteins (GFPs)
                                                   reflective imagine                         Ds Red
                                                   (FRI)                                      Hc Red
                                                   Fluorescence
                                                   molecular
                                                   tomography (FMT)

Focal atrophy            Brain injury / toxicity   MRI                      Caviness VS
                         and trauma                                         Kennedy D
Focal brain uptake       CNS AIDS /                PET                      Fischman A
                         fungal and                SPECT
                         opportunistic
                         infections
Folate receptor          Neoplasm / primary        Optical                  Ntziachristos V   Targeted
                         and secondary                                      Weissleder R      Fluorochromes




                                                              Page 51 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                12/11/2011
Frontal language area Autism                   MRI                Caviness VS       Reversal of
                                                                  Harris G          morphometric
                                                                  Kennedy D         asymmetry in
                                                                                    frontal language
                                                                                    area
Frontal language area Autism                   fMRI               Harris G          Abnormal fMRI
                                                                                    activation of frontal
                                                                                    language areas
                                                                                    during semantic
                                                                                    language tasks

Gallbladder wall      Cholecystitis            US                 Hahn P
thickening                                     CT                 Mueller P
                                               MRI                O'Neill MJ

Gallstones            Cholelithiasis           US                 Hahn P
                                               CT                 Mueller P
                                               MRI                O'Neill MJ

Gallstones            Cholecystitis            US                 Hahn P
                                               CT                 Mueller P
                                               MRI                O'Neill MJ

Glucose               Hepatic                  MRS                Grant E
                      encephalopathy                              Jenkins BG
                                                                  Schaefer P
Glucose metabolism    Breast neoplasm          PET                Alpert NM
                                                                  Choi NC
                                                                  Fischman AJ
Glucose metabolism    Head and neck            PET                Alpert N          Non-specific marker
                      neoplasm / primary                          Choi N            with wide variety of
                      and secondary                               Fischman A        applications

Glucose metabolism    Hepatic neoplasm /       PET                Fischman AJ       Non-specific marker
                      primary and                                                   with wide variety of
                      secondary                                                     applications

Glucose metabolism    Lung neoplasm / non      PET                Choi NC           Pilot trial in NSCLC
                      small cell carcinoma                        Fischman AJ       showed good
                                                                  Weissleder R      inverse correlation
                                                                                    between MR post
                                                                                    radiation and
                                                                                    outcomes

Glucose metabolism    Osseous neoplasm /       PET                Fischman AJ
                      primary and
                      secondary
Glucose metabolism    Ovarian neoplasm /       PET                Fischman AJ       Non-specific marker
                      presence and viability                                        with wide variety of
                                                                                    applications

Glucose metabolism    Pulmonary neoplasm / PET                    Fischman AJ       Non-specific marker
                      presence and viability                                        with wide variety of
                                                                                    applications

Glucose metabolism    Renal neoplasm /       PET                  Fischman AJ
                      primary and
                      secondary
Glucose metabolism    Soft tissue neoplasm / PET                  Fischman AJ       Non-specific marker
                      primary and                                                   with wide variety of
                      secondary                                                     applications

Glucose metabolism    CNS neoplasm /           PET                Alpert N          Non-specific marker
                      primary and                                 Choi N            with wide variety of
                      secondary, presence                         Fischman A        applications
                      and viability                               Kennedy D
                                                                  Rosen B
Glucose transporter   Neoplasm / primary       Optical            Ntziachristos V   Targeted
                      and secondary                               Weissleder R      Fluorochromes



                                                         Page 52 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                       12/11/2011
Glucose uptake           Glioma                   PET                   Fischman A
                                                                        Kennedy D
                                                                        Rosen B
Ground-glass             Respiratory syncytial    CT                    McLoud TC
appearance               virus                                          Shepard J
Hippocampal size         Alzheimer's disease      MRI                   Dale A              Accurately indicates
                                                  Quantitative          Hyman B             absence of disease
                                                  volumetric            Fischl B            progression in
                                                  morphometry           Kennedy D           therapeutic trials -
                                                                                            allows markedly
                                                                                            reduced subject
                                                                                            numbers

Hippuran clearance       Renal disease            PET                   Alpert NM
                                                                        Fischman AJ
Human transferrin        Neoplasm / primary       MRI                   Weissleder R        Receptor binding
receptor                 and secondary                                                      probe linking
                                                                                            transferrin and
                                                                                            monocrystalline iron
                                                                                            oxide (Tf-MION)

Hyperperfusion           Epilepsy                 MRI / arterial spin   Hoge R
                                                  labeling              Kwong KK
Increased abdominal AIDS wasting                  Quantitative CT       Rosenthal DI
visceral fat associated syndrome /                Dual energy X-ray
with decreased bone     lipodystrophy             absorptiometry
mineral density                                   (DEXA)

Increased Cerebral       HIV                      fMRI                  Gonzalez RG         Cerebral injury
blood volume (CBV)                                                      Hunter G            related to HIV
                                                                                            infection
Increased pulmonary      Allergic drug reaction   CT                    McLoud TC
interstitial markings                                                   Shepard J

Increased pulmonary      Connective tissue        CT                    McLoud TC Shepard
interstitial markings    disorders                                      J

Increased pulmonary      Interstitial pulmonary   CT                    McLoud T
interstitial markings    edema                                          Shepard J




Increased pulmonary      Lymphangio-              CT                    McLoud TC
interstitial markings    carcinomatosis                                 Mueller PR
                                                                        Shepard J
                                                                        Weissleder R
Increased pulmonary      Pulmonary infection      CT                    McLoud TC
interstitial markings                                                   Shepard J

Increased synovial       Arthritis / septic       MRI                   Palmer W
glucose metabolism                                                      Rosenthal DI

Increased synovial       Arthritis /              PET                   Fischman AJ
glucose metabolism       inflammatory                                   Palmer W
                                                                        Rosenthal DI
Increased synovial       Pigmented villonodular PET                     Fischman AJ
glucose metabolism       synovitis                                      Palmer W
                                                                        Rosenthal DI
Increasing periosteal    Osteoarticular allograft MRI                   Palmer WE           3-4 months post
and endosteal            imaging                                        Rosenthal DI        allograft /
enhancement                                                                                 represents vascular
                                                                                            ingrowth and early
                                                                                            skeletal repair

Infiltration of tunica   Rectal carcinoma /       MRI                   Hahn P
muscularis               advanced staging         Multidetector CT      Saini S
Presence of positive                              angiography (MDCT)    O'Neill MJ
nodes                                             US                    Mueller P




                                                             Page 53 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                12/11/2011
Inflammation            Crohn's disease        MR enteroclysis     Hahn P           Use of experimental
                                                                                    oral contrast Kaolin,
                                                                                    locus bean gum,
                                                                                    methylcellulose +
                                                                                    Barium

Intraluminal            Gastrointestinal       SPECT               Fischman AJ
hemorrhage              bleeding
Intravascular           Acute myocardial       MRI                 Brady T
thrombus                infarction
Intravascular           Arterial embolism      CT                  Waltman A
thrombus                                       MRI
                                               Angiography
Intravascular           Deep venous            US                  O’Neill MJ
thrombus                thrombosis             MRI                 Waltman A
                                               Angiography
Intravascular           Portal vein thrombosis US                  Hahn P
thrombus                                       CT                  Mueller P
                                               MRI                 O’Neill MJ
                                               Angiography         Waltman A
Intravascular           Pulmonary embolism CT                      McLoud T
thrombus
Intravascular           Stroke                 CT / CTA              Caviness VS
thrombus                                       MRI / MRA             Gonzalez RG
                                               Angiography           Schaefer P
                                                                     Sorensen AG
Ischemic brain tissue   Stroke / ischemic      Diffusion / perfusion Gonzalez R
                                               weighted imaging      Harris G
                                               MRI                   Sorensen AG
                                               CT perfusion
                                               CTA

Joint space narrowing   Arthritis              Plain radiographs   Palmer W
                                                                   Rosenthal DI
Lactate                 Hepatic                MRS                 Grant E
                        encephalopathy                             Jenkins BG
                                                                   Schaefer P
Lactate                 Huntington's disease   MRS                 Jenkins BG
                                                                   Rosen B
Lactate                 CNS neoplasm /         MRS                 Gonzalez R       Metabolism, tumor
                        primary and                                Husiman TA       viability and
                        secondary                                  Sorensen AG      response to therapy

Lactate : choline ratio Asphyxia               MRS                 Jenkins B

Lesion detection        Hepatic neoplasm /     MRI                 Hahn PF          Increased SNR and
                        primary and                                Harisinghani M   CNR with liver
                        secondary                                  Saini S          specific contrast
                                                                   Weissleder R     agent GD-BOPTA
                                                                                    and mangafodipir

Lesion volume           Adenopathy,            US                  Harisinghani M   Anatomic marker of
                        lymphoma and           CT                  Mueller PR       disease presence
                        metastatic disease     MRI                 O’Neill MJ
                                                                   Saini S
Lesion volume           CNS neoplasm /         CT                  Gonzalez R       Anatomic marker of
                        primary and            MRI morphometry     Harris G         disease presence
                        secondary                                  Kennedy D        Response to therapy
                                                                   Lev
                                                                   Schaefer P
                                                                   Sorensen AG
Lesion volume           Head and neck          CT                  Gonzalez R       Anatomic marker of
                        neoplasm / primary     MRI                 Lev MH           disease presence
                        and secondary                              Schaefer P
                                                                   Schwamm
                                                                   Sorensen AG
Lesion volume           Hepatic neoplasm /     US                  Harris G         Anatomic marker of
                        primary and            CT                  Mueller PR       disease presence
                        secondary              MRI                 O’Neill MJ
                                                                   Saini S

                                                         Page 54 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                             12/11/2011
Lesion volume         Lung neoplasm /         CT                 Hunter GJ        Anatomic marker of
                      primary and             MRI                                 disease presence
                      secondary
Lesion volume         Renal neoplasm /        US                 Mueller PR       Anatomic marker of
                      primary and             CT                 O’Neill MJ       disease presence
                      secondary               MRI                Saini S
Leukocyte             Abscess                 SPECT              Fischman AJ      Tc-99m HMPAO
accumulation                                                                      improvement over
                                                                                  Tl-201 and Ga-67



Leukocyte             Osteomyelitis           Nuclear medicine   Fischman AJ      Radiolabled IL-8
accumulation                                                                      accumulation
Leukocyte             Soft tissue infection   Nuclear medicine   Fischman AJ
accumulation

Ligament tears        Ankle injury            MR arthrography    Palmer WE        Predicts sensitivity
                                                                                  for ankle
                                                                                  impingement
                                                                                  syndromes

Liver tissue          Cholangio-carcinoma     MRI                Hahn PF          Using combined
characterization                                                 Halpern EF       ferrumoxide / Gd-
                                                                 Sahani D         DPTA
Liver tissue          Hepatic cysts           MRI                Hahn PF          Using ultrasmall
characterization                              US                 Harisinghani M   superpara-magnetic
                                                                 Mueller PR       iron oxide,
                                                                 O'Neill MJ       mangafodipir
                                                                 Weissleder R     trisodium

Liver tissue          Hepatic focal nodular   MRI                Hahn PF          Using combined
characterization      hyperplasia                                Halpern EF       ferrumoxide / Gd-
                                                                 Sahani D         DPTA

Liver tissue          Hepatic focal nodular   MRI                Hahn PF          Using ultrasmall
characterization      hyperplasia                                Harisinghani M   superpara-magnetic
                                                                 Mueller PR       iron oxide,
                                                                 Weissleder R     mangafodipir
                                                                                  trisodium

Liver tissue          Hepatic hemangioma      MRI                Hahn PF          Using ultrasmall
characterization                              US                 Harisinghani M   superpara-magnetic
                                                                 Mueller PF       iron oxide
                                                                 O'Neill MJ       OR
                                                                 Saini S          Gd-based chelates
                                                                 Weissleder R

Liver tissue          Hepatobiliary           MRI                Hahn P           Using ultrasmall
characterization      disorders                                  Harisinghani M   superpara-magnetic
                                                                 Mueller P        iron oxide,
                                                                 Weissleder R     mangafodipir
                                                                                  trisodium

Liver tissue          Hepatocellular          MRI                Hahn PF          Using ultrasmall
characterization      carcinoma                                  Harisinghani M   superpara-magnetic
                                                                 Mueller PR       iron oxide,
                                                                 Weissleder R     mangafodipir
                                                                                  trisodium

Liver tissue          Hepatocellular          MRI                Hahn PF          Using combined
characterization      carcinoma                                  Halpern EF       ferrumoxide / Gd-
                                                                 Harisinghani M   DPTA
                                                                 Sahani D
Local uptake of       Neoplasm / primary      Nuclear medicine   Fischman AJ
specific tumor avid   and secondary
radiotracers




                                                        Page 55 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                  12/11/2011
Lumen vascular          Arteriosclerosis /    CTA                   Gonzalez R
diameter                peripheral            MRA                   Hunter G
                                              Angiography           Lev M
                                                                    Waltman A
Macrophage content      Vulnerable plaque     Optical coherence     Weissleder R
                                              topography


Marrow edema            Bone fracture         MRI -T1               Palmer WE         Impact fractures
                                              Diffusion weighted                      demonstrate
                                              imaging / Apparent                      prominent edema,
                                              diffusion constant                      distraction fractures
                                                                                      exhibit minimal
                                                                                      edema

Matrix                  Neoplasm / primary    Optical               Ntziachristos V   Active, stable
metalloproteinase-2     and secondary                               Weissleder R      Fluorochromes
MMP-9
MMP-13

Mean transit time       Alzheimer's disease   SPECT                  Harris G
(MTT)                                         fMRI                   Gonzalez RG
                                                                     Sorensen AG
Mean transit time       Migraine              Diffusion / perfusion Grant E
(MTT)                                         weighted imaging       Schaefer P
                                              fMRI                   Sorensen AG
                                                                     Rosen BR
Mean transit time       Stroke                MRI (combined          Harris G         MTT helps to stratify
(MTT)                                         Arterial spin labeling Hoge R           patients in clinical
                                              and Dynamic            Ostergaard L     trials
                                              susceptibility         Rosen B          MR perfusion
                                              contrast)              Sorensen AG      territory imaging
                                              CAPTIVE                Wald LL

Mediastinal nodal       Lung neoplasm /       PET                   Fischman AJ       Physiologic imaging
status                  primary and           MRI                   McLoud TC         with FDG or iron
                        secondary             CT                    Weissleder R      oxide particles in
                                                                                      NSCLC

Micro-architecture      Osteoporosis          Digital radiographs   Rosenthal DI      Fine element
deterioration                                 3D microMRI                             modeling (FEM) to
                                              3D microCT                              predict mechanical
                                                                                      properties

Microarchitecture       Osteoporosis          Digital radiographs   Rosenthal DI      Fine element
deterioration                                 3D microMRI                             modeling (FEM) to
                                              3D microCT                              predict mechanical
                                                                                      properties

Microcalcifications     Breast neoplasm       Raman                 Feld MS (MIT)     Differential
                                              Spectroscopy                            diagnosis of benign
                                                                                      from malignant
                                                                                      microcalcifications


Microvascular blood     Breast neoplasm       US                    O'Neill MJ        Microbubble
volume                                                                                contrast agents
Microvascular blood     CNS neoplasm /        fMRI                  Belliveau
volume and              primary and           MRI                   Kennedy D
microvascular density   secondary                                   Rosen BR

Microvascular density   Breast neoplasm       US                    O'Neill MJ        Microbubble
                                                                                      contrast agents
Microvessel density     Breast neoplasm       MRI                   Kopans DB         Magnetic
(MVD)                                                                                 susceptibility-based
                                                                                      contrast agent OR
                                                                                      GD-DTPA with
                                                                                      dynamic echo planar
                                                                                      imaging


                                                        Page 56 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                              12/11/2011
MR cholangio-           Calculus disease       MRI                 Sahani D
pancreatography                                                    Prasad S
MR cholangio-           Biliary stricture      MRI                 Prasad S
pancreatography                                                    Sahani D
MS plaque               Multiple sclerosis     MRI                 Jenkins B
demylination                                                       Rosen BR
                                                                   Stufflebeam SM
Musculoskeletal blood   Skeletal muscle injury PET                 Alpert NM        Animal study Use
flow                    and repair                                 Fischman AJ      of H2(15)O to study
                                                                                    muscle metabolism

Myocardial blood flow   Coronary artery        Nuclear medicine    Fischman A
via 13N-ammonia         disease                SPECT

Myocardial blood flow   Ischemic heart disease Nuclear medicine    Fischman A
via 13N-ammonia                                SPECT

Myocardial               Coronary artery       MRI                 Brady T
contractility / function disease               Nuclear Medicine    Fischman A

Myocardial function     Myocarditis            Nuclear medicine    Fischman A
contractility




Myocardial function     Myocarditis            MRI                 Brady T
contractility




Myocardial perfusion    Coronary artery        Nuclear medicine    Fischman A
                        disease

Myoinositol             Alzheimer's disease    MRS                 Gonzalez RG
                                                                   Jenkins B
Myoinositol (MI)        CNS AIDS /             MRS                 Gonzalez R
                        neuroinflammation                          Schaefer P
                        neurodegeneration                          Schwamm LH
N-acetylaspartate       Alzheimer's disease    MRS                 Gonzalez RG
(NAA)                                                              Jenkins B
N-acetylaspartate       Hodgkin's disease      MRS                 Jenkins B
(NAA)                                                              Kennedy D
                                                                   Rosas D
                                                                   Rosen BR
N-acetylaspartate       CNS AIDS /             MRS                 Gonzalez R
(NAA)                   neuroinflammation                          Schaefer P
                        neurodegeneration                          Schwamm LH
N-acetylaspartate       Hepatic                MRS                 Grant E
(NAA)                   encephalopathy                             Jenkins BG
                                                                   Schaefer P
N-acetylaspartate       CNS neoplasm /         MRS                 Gonzalez R       Metabolism, tumor
(NAA)                   primary and                                Husiman TA       viability and
                        secondary                                  Sorensen AG      response to therapy

N-acetylaspartate       Huntington's disease   MRS                 Jenkins BG
(NAA)                                                              Rosen B
N-acetylaspartate       Brain function /       MRI chemical shift  Gonzalez RG
(NAA) Images            neuronal content       Echo-planar imaging Jenkins B
                                               (EPI)               Rosen B
N-acetylaspartate      Epilepsy                MRS                 Jenkins BG
(NAA) lateralization
N-acetylaspartate      Parkinson’s disease     MRS                 Gonzales RG
(NAA) levels over time                                             Jenkins BG

Negative defect         Bone fracture          Plain radiographs   Palmer W
                                                                   Rosenthal DI




                                                         Page 57 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                 12/11/2011
Neural activation of    Schizophrenia           PET                   Alpert N        Regional activation
dorsolateral pre-                                                     Fischman A      during cognitive
frontal cortex,                                                       Heckers S       paradigms
hippocampus and                                                       Rauch SL
cerebellum                                                            Schaefer P
Neuritic (senile)       Alzheimer's disease     In vivo multiphoton   Hyman B         Can use
plaque                                          microscopy                            histochemical or
                                                                                      immuno-
                                                                                      fluorescence for
                                                                                      amyloid B
Neuronal activation     Visual process          fMRI                  Mandeville JB
                        disorders                                     Rosen B
                                                                      Tootell RBH
Neuronal activation     Stroke                  fMRI                  Boas D          NIRS agrees well
                                                Diffuse optical       Mandeville JB   with fMRI, useful in
                                                topography (Near      Strangman G     longitudinal studies
                                                infrared
                                                spectroscopy)
Neuronal activation     Stroke                  Arterial spin labeling Wald LL
CMRO2                                           MRI
                                                O2 15 PET
                                                Xenon Enhanced CT

Neuronal injury         Alzheimer's disease     MRI                   Gonzalez RG

Opacities               Respiratory syncytial   CT                    McLoud TC
                        virus                                         Shepard J
Osseous bridging        Bone fracture /         Plain radiographs     Palmer W
                        healing                 MRI                   Rosenthal DI
                                                CT
Osteoblastic activity   Bone fracture /         Nuclear medicine      Fischman AJ
                        healing
Osteoblastic activity   Osseous neoplasm /      Nuclear medicine      Fischman A
                        primary and
                        secondary
Osteoblastic activity   Osteoarthritis          Nuclear medicine      Fischman AJ

Osteoblastic activity   Osteomyelytis           Nuclear medicine      Fischman AJ     Uptake of bone-
                                                                                      seeking radio-
                                                                                      pharmaceuticals
Osteoblastic activity   Soft tissue infection   Nuclear medicine      Fischman AJ


Osteochondral lesions Joint injury / general    MR arthrography       Palmer WE       Assesses the
                                                                                      stability of lesions
Oxygen consumption      Brain development       Optical Imaging       Boas D          Diffuse optical
                                                                      Dunn A          imaging (DOI)
Oxygen consumption      CNS neoplasm /          Optical               Boas D          Diffuse Optical
                        primary and                                   Dunn A          imagine (DOI)
                        secondary, presence
                        and viability

Oxygen consumption      Stroke                  Optical imaging       Boas, D
                                                                      Dunn, A
                                                                      Lo E
Oxygen utilization      Alzheimer's disease     Optical               Boas D          Combining of multi-
                                                                      Dunn A          wavelength and
                                                                                      laser speckle
                                                                                      contrast imaging
Partial thickness and   Elbow injury /          MR arthrography       Palmer WE       Distinguishes
full thickness tears    collateral ligament                                           thickness of tears

Perfusion / diffusion   Myocarditis             MRI                   Brady T




                                                           Page 58 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                  12/11/2011
Perfusion / diffusion   Myocarditis              Nuclear medicine    Fischman A




Peri-intestinal         Inflammatory bowl        MRI                 Hahn P            Tissue FISP pulse
inflammation            disease                                                        sequence
                        (IBD)
Peri-rectal fat         Rectal carcinoma /       MRI                 Hahn P            Predictor of high
involvement             recurrent                                    Prasad S          probability of local
                                                                     Saini S           recurrence
Perianeurysmal          Inflammatory          CT                     Brady T
fibrosis                abdominal aortic                             Saini S
                        aneurysm (IAAA)                              Waltman A
Periarticular erosion   Amyloid arthropathy / Plain radiographs      Palmer W
                        crystalline disease   MRI                    Rosenthal DI

Periarticular erosion   Arthritis /              Plain radiographs   Palmer W
                        inflammatory             MRI                 Rosenthal DI
Periarticular erosion   Arthritis / septic       Plain radiographs   Palmer W
                                                 MRI                 Rosenthal DI

Periarticular erosion   Pigmented villonodular Plain radiographs     Palmer W
                        synovitis              MRI                   Rosenthal DI

Periarticular erosion   Synovial                 Plain radiographs   Palmer W
                        chondromatosis           MRI                 Rosenthal DI

Permeability surface    Pulmonary neoplasm       PET                 Fischman AJ
area product                                     MRI                 McLoud TC

Pharmacokinetics        Neoplasm / primary       SPECT               Fischman AJ       Additional use for
Biodistribution         and secondary            PET                 Jenkins B         determining in vivo
Non-tumor uptake                                 MRS                                   heterogeneity of
                                                                                       tumor uptake

Phosphocreatine         CNS neoplasm /           MRS                 Gonzalez R        Metabolism, tumor
                        primary and                                  Husiman TA        viability and
                        secondary                                    Sorensen AG       response to therapy

Plaque Type             Vulnerable plaque        Optical coherence   Weissleder R
                                                 topography


Portal Venous invasion Pancreatic carcinoma      MRA                 Halpern EF        Better predictor
                                                                     Saini S           than conventional
                                                                     Waltman AC        angiography
Presence of             Breast neoplasm          MRI                 Kopans DB         4 of 17 patients
contralateral                                                                          (24%) had
synchronous cancers                                                                    contralateral cancer
                                                                                       occult to physical
                                                                                       exam,
                                                                                       mammography and
                                                                                       US
Prostate volume         Benign prostatic         US                  Hahn PF
                        hypertrophy              CT                  Mueller PR
                                                 MRI                 O’Neill MJ
Prostate volume         Prostate cancer          US                  Hahn PF
                                                 CT                  Mueller PR
                                                 MRI                 O'Neill MJ
Prostate-specific       Prostate cancer          Optical             Ntziachristos V   Active, stable
antigens (PSA)                                                       Weissleder R      Fluorochromes
Pulmonary               Alveolar pulmonary       CT                  McLoud T
consolidation           edema                    MRI                 Shepard J
Pulmonary               Aveolar bronchial cell   CT                  McLoud TC
consolidation           carcinoma                MRI                 Shepard J
Pulmonary               Pneumonitis              CT                  McLoud TC
consolidation                                    MRI                 Shepard J
                                                 Plain radiographs

                                                           Page 59 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                12/11/2011
Pulmonary               Pneumonitis            CT                   McLoud TC
consolidation                                  MRI                  Shepard J
rCMRO2                  Brain function / drugs fMRI                 Jenkins B        Response to stimuli
                        of abuse                                    Kosofsky B
                                                                    Mandeville JB
                                                                    Rosen B
Regional blood flow     Breast neoplasm        MRI                  Kopans DB        Magnetic
and blood volume                                                                     susceptibility-based
                                                                                     contrast agent OR
                                                                                     GD-DTPA with
                                                                                     dynamic echo planar
                                                                                     imaging

Relative % contrast     Adrenal neoplasm       CT                   Boland GW        Differential
washout                                                             Hahn PF          diagnosis of adrenal
                                                                    Mueller PR       masses
Relative cerebral blood Anorexia               PET                  Alpert N
flow (rCBF)                                                         Fischman A
                                                                    Rauch SL
Relative cerebral blood Brain function /       Pharmacologic MRI    Bogdanov M       Using D-
flow (rCBF)             mapping -              PET                  Chen YC          amphetamine and
                        dopaminergic           fMRI                 Jenkins B        CFT
                        neurotransmitter                            Rosen B
                        activity
Relative cerebral blood Stroke                 Diffusion weighted Kennedy D
flow index (rCBF)                              imaging            Lo E
                                               fMRI               Rosen B
                                               MRI (morphometry)

Relative cerebral blood Hypertension           Dynamic              Hunter G         Using Gd-DTPA
volume (rCBV)                                  susceptibility       Rosen B          following L-arginine
                                               contrast MRI                          infusion

Relative cerebral blood Stroke / ischemic      CAPTIVE MRI          Bogdanov A
volume (rCBV)                                                       Jenkins B
                                                                    Kwong K
                                                                    Weissleder R
Relative cerebral blood Brain function /       Pharmacologic MRI    Bogdanov M       Using D-
volume (rCBV)           mapping -              PET                  Chen YC          amphetamine and
                        dopaminergic           fMRI                 Jenkins B        CFT
                        neurotransmitter                            Rosen B
                        activity
Restricted diffusion    Abscess                Diffusion weighted   Grant E
                                               imaging              Gonzalez RG
                                                                    Schaefer P
Restricted diffusion    Infectious disease /   Diffusion weighted   Grant, E
                        -empyema               imaging              Schaefer P
                        -herpes virus
                        -CJD
Restricted diffusion    Migraine               Optical              Boas D
                                                                    Dunn A
Restricted water        Brain injury           Diffusion weighted   Huisman TA       Cytotoxic edema,
mobility                                       imaging              Gonzalez RG      vasogenic edema
                                               Apparent diffusion   Schaefer P       and diffuse axonal
                                               constant             Sorensen AG      injury
Right posterior hepatic Cirrhosis              MRI                  Hahn PF          Discrimination of
notch                                          CT                   Sahani D         alcohol from virus-
                                                                                     induced cirrhosis
ROC curve analysis of Ovarian neoplasm /       CT                   O'Neill MJ       Predictive model of
13 CT radiographic    presence and viability                                         relative success of
parameters                                                                           surgical
                                                                                     cytoreduction

Seizure focus           Epilepsy               MEG / EEG            Halgren E
                                                                    Stufflebeam SM




                                                           Page 60 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                   12/11/2011
Soft tissue             Myopathy                 MRI                 Palmer W
inflammation                                                         Rosenthal DI




Soft tissue             Neoplasm / primary       Nuclear medicine    Fischman AJ
inflammation            and secondary            MRI                 Palmer WE
                                                                     Rosenthal DI
Soft tissue             Soft tissue infection    MRI                 Fischman AJ
inflammation                                     Nuclear medicine    Palmer W
                                                                     Rosenthal DI
Soft tissue             Trauma                   MRI                 Palmer W
inflammation                                                         Rosenthal DI
Soft tissue             Trauma                   Nuclear medicine    Fischman AJ
inflammation
Soft tissue             Simple renal cysts       US                  Mueller PR
inflammation                                     CT
                                                 MRI
Soft tissue uptake of Trauma                     Nuclear medicine    Fischman AJ
radiotracers
Somatostatin receptor Neoplasm / primary         Optical             Ntziachristos V   Targeted
                      and secondary                                  Weissleder R      Fluorochromes

Spatial cartilage       Joint injury / hip and   Co-planar MRI       Palmer WE         MR using fat-
thickness               knee                                         Rosenberg AE      saturated 3D spoiled
                                                                     Rosenthal DI      gradient-echo
                                                                                       images (SPGR)

Specific regional       Schizophrenia            fMRI                Kuperberg G       Regional activation
uptake, target                                                       Manoach D         during cognitive
selection and                                                        Stufflebeam SM    paradigms
functional activation                                                Rosen B

Spermine levels         Prostate cancer          MRS magic angle     Cheng LL          Proposed
                                                 spinning            Gonzalez RG       endogenous
                                                                                       inhibitor of prostate
                                                                                       CA growth

Spiculated lymph node Rectal carcinoma /         MRI                 Hahn P            Predictor of high
                      recurrent                                      Prasad S          probability of local
                                                                     Saini S           recurrence
Splenic tissue          Splenic cysts            MRI                 Hahn PF           Using ultrasmall
characterization                                                     Harisinghani M    superpara-magnetic
                                                                     Mueller PR        iron oxide
                                                                     Weissleder R
Splenic tissue          Splenic neoplasm         MRI                 Hahn PF           Using ultrasmall
characterization                                                     Harisinghani M    superpara-magnetic
                                                                     Mueller PR        iron oxide
                                                                     Weissleder R
Splenic tissue          Splenic trauma           MRI                 Harisinghani M    Using ultrasmall
characterization                                                     Weissleder R      superpara-magnetic
                                                                                       iron oxide

Subendothelial lipid    Vulnerable plaque        Optical coherence   Brady T
pool                                             topography          Muller J
                                                 Near infrared
                                                 spectroscopy
Synovial thickening     Arthritis /              MRI                 Palmer W
                        inflammatory                                 Rosenthal DI
Synovial thickening     Arthritis / septic       Plain radiographs   Palmer W
                                                 MRI                 Rosenthal DI

Synovial thickening     Pigmented villonodular MRI                   Palmer W
                        synovitis                                    Rosenthal DI




                                                           Page 61 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                                 12/11/2011
Targeted cellular and   CNS neoplasm /          Optical                Kwong KK       Exogenous contrast
molecular probes        primary and             MRI                    Weissleder R   agents
                        secondary, presence     PET                                   Animal models
                        and viability

Targeted mircobubble Vulnerable plaque          Contrast enhanced      O'Neill MJ
contrast agents                                 US                     Waltman A


Thalamic neuronal loss Multiple sclerosis        MRI                   Gonzalez RG
                                                 fMRI                  Fischl B
                                                 MRS                   Kuperberg G
Thalamus and            Encephalitis / west nile MRI                   Gonzalez RG    Disease
substantia nigra        virus                                          Sorensen AG    confirmation and
hyperintensities                                                                      progression
                                                                                      monitoring
Thickness and         Vulnerable plaque         Intravascular US       Brady T
composition of plaque                           IVUS                   Lev M
                                                                       O'Neill NJ
                                                                       Waltman A
Tissue characterization Osseous neoplasm /      CT                     Rosenthal DI
                        primary and             MRI
                        secondary
Tissue characterization Multiple sclerosis      fMRI                   Fischl B
                                                MRI morphometry        Kuperberg G

Trabecular pore size    Osteoporosis            MRI                    Rosenthal DI

Tumor angiogenesis      CNS neoplasm /          MRI                    Davis T        Measured by
                        primary and             MRS                    Rosen B        dynamic
                        secondary               MRA                    Wald LL        susceptibility
                                                                       Weissleder R   contrast (DSC) and
                                                                                      monocrystalline iron
                                                                                      oxide nanoparticles
                                                                                      (MION)


Tumor angiogenesis      Glioma                  MRI                    Davis T        Measured by
                                                MRS                    Rosen B        dynamic
                                                MRA                    Wald LL        susceptibility
                                                                       Weissleder R   contrast (DSC) and
                                                                                      monocrystalline iron
                                                                                      oxide nanoparticles
                                                                                      (MION)


Tumor angiogenesis      Neoplasm / primary      MRI Dynamic            Bogdanov A     High resolution MR
                        and secondary           susceptibility         Bremer C       using long
                                                contrast (DSC) /       Rosen BR       circulating iron
                                                monocrystalline iron   Weissleder R   oxide contrast
                                                oxide nanoparticles                   agents
                                                (MION)                                Rodent model

Tumor angiogenesis      Neoplasm / primary      MRI                    Bogdanov A     Animal model using
Macromolecular          and secondary           SPECT                  Weissleder R   pegylated DOTA
contrast extravasate                                                                  derivatized graft
                                                                                      copolymers

Tumor associated        Breast neoplasm         Optical                Bremer C       Expression levels of
enzymatic activity                              Near infrared          Bogdanov A     cathepsin-B activity
                                                spectroscopy           Weissleder R   in animal models of
                                                                                      breast cancer




                                                          Page 62 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                               12/11/2011
Tumor growth rate       CNS neoplasm /         MRI                  Bogdanov A     Serial studies of
                        primary and                                 Weissleder R   tumor volume using
                        secondary                                                  uptake of long-
                                                                                   circulating dextrin
                                                                                   coated iron oxide
                                                                                   (LCDIO)
                                                                                   Rodent model

Tumor growth rate       CNS Neoplasm /         MRI                  Tang Y         Transgenic murine
                        schwannoma and                              Weissleder R   models of
                        neurofibromatosis                                          neurofibromatosis
Tumor growth rate       Neoplasm / primary     MRI                  Bogdanov A     SPECT via uptake of
                        and secondary          SPECT                Kwong K        long-circulating
                                               Dual tracer NMR      Weissleder R   dextrin coated iron
                                                                                   oxide
                                                                                   (LCDIO)
                                                                                   Rodent model
Tumor margin            Glioma                 MRI                  Weissleder R   Via ultra small
                                                                                   particulate iron
                                                                                   oxide (USPIO)
Tumor mass              Neoplasm / primary     Optical              Weissleder R
                        and secondary

Tumor volume            Breast neoplasm        MRI                  Harris G

Tumoral proteinase      Neoplasm / primary     Optical              Bogdanov A     Rodent model
                        and secondary          Near infrared        Mahmood U
                                               spectroscopy         Weissleder R
Vascular architecture   Hepatic neoplasm /     Multidector CT       Hahn PF        Presurgical
                        primary and            angiography          Mueller PR     treatment planning
                        secondary              (MDCTA)              Saini S
                                                                    Sahani D
Vascular diameter and Iliac aneurysm           US                   Waltman A
circumference                                  CT
                                               MRI
Vascular diameter and Aortic aneurysm          US                   Waltman A
circumference                                  CT
                                               MRI
Vascular involvement    Pancreatic carcinoma   MRA                  Halpern EF     Better predictor
                                                                    Saini S        than conventional
                                                                    Waltman AC     angiography
Vascular lumen          Arteriosclerosis /     CTA                  Gonzalez R
diameter                central                MRA                  Hunter G
                                               Angiography          Lev M
                                                                    Waltman A
Vascular lumen          Dissection /           CT                   Waltman A
diameter                peripheral             MRI
                                               Angiography
Vascular occlusion      Stroke / ischemic      Diffusion / perfusion Gonzalez R
                                               weighted imaging      Harris G
                                               MRI                   Sorensen AG
                                               CT perfusion
                                               CTA

Vascular volume         Glioma                 Optical              Weissleder
fraction

Vascular volume         Sarcoma                Optical              Weissleder R
fraction
Ventilation / perfusion Pulmonary embolism     Nuclear medicine     Fischman A
mismatch
Water content           Bone fracture          MRI -T1              Palmer WE      Impact fractures
                                               Diffusion weighted                  demonstrate
                                               imaging / Apparent                  prominent edema,
                                               diffusion constant                  distraction fractures
                                                                                   exhibit minimal
                                                                                   edema




                                                         Page 63 of 84
   5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                                                              12/11/2011
Water EF             Stroke / ischemic    CAPTIVE MRI       Bogdanov A
                                                            Jenkins B
                                                            Kwong K
                                                            Weissleder R
Whole brain          Obsessive compulsive MRI (morphometry) Kennedy D            Findings include sig.
morphometry          disorder                               Rosen BR             less total white-
                                                                                 matter and greater
                                                                                 cortex and opercular
                                                                                 volumes




*Given the breadth of biomarkers in imaging and the rapid progress being made in this area, this catalog necessarily
represents a work in progress. While the Center has done its best to incorporate imaging biomarkers from beyond the
MGH community, our limited resources mean that the foundation of this catalog is the imaging biomarkers available at
MGH.




                                                    Page 64 of 84
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Disease
Category
Oncology /
Neoplasm
Gastrointestinal
Oncology /
Neoplasm
Gastrointestinal
Oncology /
Neoplasm
Inflammatory



Neurological


Endocrine
Metabolic
Gastrointestinal


Infectious disease


Neurological


Cardiology /
Vascular


Neurological
Cardiology /
Vascular

Neurological
Cardiology /
Vascular
Inflammatory
Cardiology /
Vascular
Oncology /
Neoplasm
Neurological
Metabolic


Oncology /
Neoplasm

Oncology /
Neoplasm

Oncology /
Neoplasm

Neurological
Cardiology /
Vascular


Neurological




Cardiology /
Vascular
Metabolic
                                               Page 65 of 84
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Cardiology /
Vascular
Metabolic
Cardiology /
Vascular
Metabolic
Musculoskeletal


Musculoskeletal
Inflammatory
Musculoskeletal
Inflammatory
Musculoskeletal
Inflammatory
Musculoskeletal




Musculoskeletal

Neurological
Cardiology/ Vascular
Inflammatory

Neurological

Musculoskeletal

Gastrointestinal


Gastrointestinal
Infectious disease

Gastrointestinal
Infectious disease
Inflammatory
Endocrine
Inflammatory
Gastrointestinal
Metabolic
Neurological




Neurological

Neurological
Oncology /
Neoplasm

Endocrine
Metabolic
Musculoskeletal
Infectious disease
Gastrointestinal
Endocrine
Metabolic
Musculoskeletal
Gastrointestinal
Musculoskeletal
Metabolic




                                               Page 66 of 84
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Endocrine
Metabolic
Musculoskeletal



Endocrine
Metabolic
Musculoskeletal



Gastrointestinal
Inflammatory




Gastrointestinal
Inflammatory

Musculoskeletal
Inflammatory

Oncology /
Neoplasm

Gastrointestinal
Infectious disease
Inflammatory
Neurological
Metabolic


Neurological
Metabolic


Neurological
Metabolic

Neurological
Metabolic
Neurological
Oncology /
Neoplasm


Neurological

Neurological

Neurological




Neurological
Cardiology /
Vascular
Neurological




Neurological

Neurological
Oncology /
Neoplasm



                                               Page 67 of 84
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Neurological




Neurological
Metabolic

Neurological
Cardiology /
Vascular




Neurological
Cardiology /
Vascular

Neurological
Metabolic


Neurological
Cardiology /
Vascular




Neurological
Oncology /
Neoplasm
Neurological
Metabolic

Neurological


Neurological




Musculoskeletal
Oncology /
Neoplasm


Gastrointestinal
Inflammatory
Metabolic
Infectious disease
Endocrine
Neurological


Neurological


Neurological
Oncology /
Neoplasm

Neurological
Inflammatory


Neurological




                                               Page 68 of 84
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Neurological
Cardiology /
Vascular


Neurological
Inflammatory

Oncology /
Neoplasm
Gastrointestinal
Neurological




Neurological


Neurological
Cardiology /
Vascular
Neurological
Musculoskeletal




Neurological




Neurological


Musculoskeletal

Neurological




Neurological
Inflammatory

Neurological


Neurological


Neurological




Gastrointestinal
Genitourinary
Infectious disease
Infectious disease
Musculoskeletal
Inflammatory
Oncology /
Neoplasm

Musculoskeletal
Inflammatory




                                               Page 69 of 84
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Oncology /
Neoplasm
Genitourinary
Oncology /
Neoplasm
Musculoskeletal
Oncology /
Neoplasm
Genitourinary


Musculoskeletal


Oncology /
Neoplasm
Endocrine

Neurological
Inflammatory

Metabolic
Endocrine
Oncology /
Neoplasm
Gastrointestinal
Neurological
Infectious disease




Neurological
Infectious disease




Infectious disease


Neurological


Oncology /
Neoplasm

Neurological

Neurological
Metabolic


Metabolic
Endocrine

Musculoskeletal




Neurological
Musculoskeletal

Neurological


Neurological




                                               Page 70 of 84
    5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                   12/11/2011
Neurological


Neurological




Gastrointestinal
Infectious disease
Inflammatory
Gastrointestinal
Inflammatory
Metabolic
Infectious disease
Endocrine
Neurological


Musculoskeletal
Inflammatory


Cardiology /
Vascular




Neurological
Metabolic


Oncology /
Neoplasm

Musculoskeletal
Inflammatory

Musculoskeletal
Inflammatory

Neurological
Cardiology /
Vascular
Inflammatory
Neurological
Cardiology /
Vascular




Oncology /
Neoplasm




Neurological

Neurological




Oncology /
Neoplasm




                                               Page 71 of 84
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Neurological




Neurological




Endocrine
Inflammatory
Infectious disease
Gastrointestinal
Endocrine
Inflammatory
Gastrointestinal
Metabolic
Endocrine
Inflammatory
Infectious disease
Gastrointestinal
Neurological


Oncology /
Neoplasm

Neurological
Oncology /
Neoplasm

Oncology /
Neoplasm
Gastrointestinal

Oncology /
Neoplasm




Oncology /
Neoplasm
Musculoskeletal
Oncology /
Neoplasm
Genitourinary

Oncology /
Neoplasm


Oncology /
Neoplasm
Genitourinary
Oncology /
Neoplasm
Musculoskeletal

Neurological
Oncology /
Neoplasm


Oncology /
Neoplasm



                                               Page 72 of 84
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Neurological
Oncology /
Neoplasm
Infectious disease

Neurological
Metabolic




Metabolic
Endocrine
Oncology /
Neoplasm




Neurological

Endocrine
Metabolic
Musculoskeletal
Infectious disease
Gastrointestinal
Infectious disease


Endocrine
Metabolic
Inflammatory
Inflammatory


Inflammatory
Cardiology /
Vascular
Infectious Disease

Oncology /
Neoplasm


Infectious disease


Infectious disease
Musculoskeletal
Inflammatory
Musculoskeletal
Inflammatory

Inflammatory
Musculoskeletal

Musculoskeletal




Gastrointestinal
Oncology /
Neoplasm




                                               Page 73 of 84
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Gastrointestinal
Inflammatory




Gastrointestinal

Cardiology /
Vascular
Cardiology /
Vascular

Cardiology /
Vascular

Cardiology /
Vascular
Gastrointestinal

Cardiology /
Vascular
Neurological
Cardiology /
Vascular

Neurological
Cardiology /
Vascular



Musculoskeletal
Inflammatory
Neurological


Neurological

Neurological
Oncology /
Neoplasm

Neurological

Oncology /
Neoplasm
Gastrointestinal



Oncology /
Neoplasm
Genitourinary

Neurological
Oncology /
Neoplasm



Neurological
Oncology /
Neoplasm


Oncology /
Neoplasm
Gastrointestinal



                                               Page 74 of 84
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Oncology /
Neoplasm

Oncology /
Neoplasm
Genitourinary
Neurological
Inflammatory
Musculoskeletal
Genitourinary
Infectious disease
Gastrointestinal
Infectious disease
Musculoskeletal
Infectious disease
Musculoskeletal
Inflammatory
Musculoskeletal




Oncology /
Neoplasm
Gastrointestinal
Gastrointestinal




Oncology /
Neoplasm
Gastrointestinal
Endocrine
Oncology /
Neoplasm
Gastrointestinal
Endocrine


Oncology /
Neoplasm
Gastrointestinal




Gastrointestinal




Oncology /
Neoplasm
Gastrointestinal



Oncology /
Neoplasm
Gastrointestinal

Musculoskeletal
Oncology /
Neoplasm




                                               Page 75 of 84
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Cardiology /
Vascular
Metabolic

Neurological
Cardiology /
Vascular
Inflammatory
Musculoskeletal




Oncology /
Neoplasm




Neurological
Metabolic

Neurological




Neurological
Cardiology /
Vascular




Oncology /
Neoplasm




Musculoskeletal
Metabolic




Musculoskeletal
Metabolic




Oncology /
Neoplasm




Oncology /
Neoplasm
Neurological
Oncology /
Neoplasm

Oncology /
Neoplasm
Oncology /
Neoplasm




                                               Page 76 of 84
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Endocrine
Gastrointestinal
Gastrointestinal

Neurological
Inflammatory

Musculoskeletal




Cardiology /
Vascular
Metabolic
Cardiology /
Vascular

Cardiology /
Vascular
Metabolic
Cardiology /
Vascular
Inflammatory
Infectious disease
Endocrine
Metabolic
Cardiology /
Vascular
Inflammatory
Infectious disease
Endocrine
Metabolic
Cardiology /
Vascular
Metabolic
Neurological
Metabolic
Neurological


Neurological
Metabolic
Oncology /
Neoplasm


Neurological


Neurological


Neurological
Oncology /
Neoplasm

Neurological

Neurological
Metabolic

Neurological

Neurological


Musculoskeletal




                                               Page 77 of 84
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Neurological




Neurological
Metabolic




Neurological


Neurological
Cardiology /
Vascular


Neurological
Cardiology /
Vascular


Neurological
Metabolic
Infectious disease

Musculoskeletal
Metabolic

Musculoskeletal
Metabolic
Oncology /
Neoplasm
Musculoskeletal
Musculoskeletal
Inflammatory
Musculoskeletal
Infectious disease

Infectious disease
Musculoskeletal
Inflammatory
Musculoskeletal

Neurological
Metabolic
Neurological
Oncology /
Neoplasm


Neurological
Cardiology /
Vascular
Neurological
Metabolic


Musculoskeletal


Cardiology /
Vascular
Inflammatory
Infectious disease
Endocrine
Metabolic




                                               Page 78 of 84
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Cardiology /
Vascular
Inflammatory
Infectious disease
Endocrine
Metabolic
Gastrointestinal
Inflammatory

Gastrointestinal
Oncology /
Neoplasm
Inflammatory
Cardiology /
Vascular
Musculoskeletal
Inflammatory
Metabolic
Musculoskeletal
Inflammatory
Infectious disease
Musculoskeletal
Inflammatory
Inflammatory
Musculoskeletal

Musculoskeletal
Oncology /
Neoplasm
Oncology /
Neoplasm

Oncology /
Neoplasm




Neurological
Oncology /
Neoplasm

Neurological
Cardiology /
Vascular
Inflammatory
Oncology /
Neoplasm
Gastrointestinal
Oncology /
Neoplasm




Oncology /
Neoplasm
Genitourinary
Oncology /
Neoplasm
Genitourinary
Oncology /
Neoplasm
Cardiology /
Vascular
Oncology /
Neoplasm
Infectious disease
Inflammatory



                                               Page 79 of 84
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Infectious disease
Inflammatory
Neurological
Metabolic


Oncology /
Neoplasm




Oncology /
Neoplasm
Genitourinary
Neurological


Neurological
Metabolic




Neurological
Cardiology /
Vascular


Neurological
Cardiology /
Vascular

Neurological
Cardiology /
Vascular

Neurological
Metabolic




Neurological
Inflammatory
Infectious disease
Neurological
Infectious disease


Neurological

Neurological




Gastrointestinal
Infectious disease
Inflammatory
Oncology /
Neoplasm
Genitourinary


Neurological




                                               Page 80 of 84
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Endocrine
Inflammatory
Infectious Disease
Cardiology /
Vascular

Oncology /
Neoplasm

Infectious disease
Musculoskeletal
Inflammatory
Musculoskeletal
Inflammatory
Musculoskeletal
Inflammatory
Oncology /
Neoplasm
Genitourinary
Musculoskeletal
Inflammatory
Oncology /
Neoplasm

Musculoskeletal




Neurological




Oncology /
Neoplasm
Genitourinary


Gastrointestinal
Oncology /
Neoplasm
Oncology /
Neoplasm
Gastrointestinal

Oncology /
Neoplasm
Gastrointestinal

Gastrointestinal
Cardiology /
Vascular

Neurological
Cardiology /
Vascular

Musculoskeletal
Inflammatory
Infectious disease
Musculoskeletal
Inflammatory
Musculoskeletal
Oncology /
Neoplasm




                                               Page 81 of 84
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Neurological
Oncology /
Neoplasm


Neurological
Cardiology /
Vascular
Inflammatory
Neurological
Inflammatory

Neurological
Infectious disease
Inflammatory

Neurological
Cardiology /
Vascular
Inflammatory
Oncology /
Neoplasm
Musculoskeletal
Neurological
Inflammatory

Musculoskeletal
Metabolic
Neurological
Oncology /
Neoplasm




Neurological
Oncology /
Neoplasm




Oncology /
Neoplasm




Oncology /
Neoplasm




Oncology /
Neoplasm




                                               Page 82 of 84
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Neurological
Oncology /
Neoplasm




Neurological
Oncology /
Neoplasm
Oncology /
Neoplasm




Neurological
Oncology /
Neoplasm
Oncology /
Neoplasm

Oncology /
Neoplasm
Oncology /
Neoplasm

Oncology /
Neoplasm
Gastrointestinal

Cardiology /
Vascular

Cardiology /
Vascular

Oncology /
Neoplasm
Gastrointestinal
Metabolic
Cardiology /
Vascular

Cardiology /
Vascular

Neurological
Cardiology /
Vascular



Neurological
Oncology /
Neoplasm
Oncology /
Neoplasm
Cardiology /
Vascular
Musculoskeletal




                                               Page 83 of 84
             5a190464-e390-4a2b-b4dd-71eedb1cd77d.xls                   12/11/2011
         Neurological
         Cardiology /
         Vascular

         Neurological




his catalog necessarily
markers from beyond the
 biomarkers available at




                                                        Page 84 of 84

				
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