Study Design

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					PCI-CURE

           Study Design
                CURE                                              PCI-CURE

                                               N = 2,658 patients undergoing PCI
                       Pretreatment
                                         Open-label thienopyridine
   PLACEBO
    + ASA *                                      N = 1345


                                                                                       End of follow-up
                                  PCI                         30 days post PCI         Up to 12 months
           R                                                                          after randomization


                                         Open-label thienopyridine
CLOPIDOGREL
   + ASA *
                                                N = 1313
                       Pretreatment
* In combination with standard therapy
 Mehta, SR. et al for the CURE Trial Investigators. N Engl J Med. 2001;345:494-502.
PCI-CURE

           Overall Long-Term Results
          Composite of cardiovascular death or MI from randomization to end of follow-up
                                    0.15                                             12.6%
                                                      Placebo
                                                      + ASA*
           Cumulative Hazard Rate




                                    0.10                                              8.8%

                                                                      Clopidogrel
                                                                        + ASA*
                                    0.05
                                                                                    31% RRR
                                                                                    P = 0.002
                                                                                     N = 2658
                                      0.0
                                            0   100          200           300         400
                                                      Days of follow-up
* In combination with standard therapy
Mehta, SR. et al for the CURE Trial Investigators. Lancet. August 2001.

				
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