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About Frontiers in Bioscience Research Institute
Frontiers in Bioscience research institute in aging and cancer was launched
in 2011. The mission of the institute is to find cure for cancer, identify
pathways for reversal of aging and to provide a forum for public education
and fund raising. Scientists at the institute will examine innovative non-
radiotherapeutic and non-chemotherapeutic approaches for treatment of all
solid cancers. New ideas that can reverse the age induced damage to DNA
and cell organelles will also be pursued. The institute will also launch a
rejuvenation clinic for slowing down the speed of aging. Interested
individuals can contact the institute for further information. The institute will
be funded through tax deductible donations, fund raising events, and
educational programs. Various galleries participate in fund raising through
providing artworks that are gifted to philanthropic donors.
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Frontiers in Bioscience
Research Institute
16471 Scientific Way
Irvine, CA 92618
www.bioscience.org/ri.htm
fbs@bioscience.org
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Siamak Tabibzadeh obtained his MD
degree in 1977, was board certified
in Pathology in 1982 and became
assistant professor in Pathology in
1983. He was promoted to the rank
of associate professor and then to
the position of full professor at
University of South Florida in early
1990s and obtained full professor
position at Stony Brook University in
2000 and at UCI in 2011. Dr Siamak Tabibzadeh, MD
Tabibzadeh has authored over 100 President, Full professor
publications, has six patents and Frontiers in Bioscience Research
cloned one of the human genes Institute in Aging and Cancer
(EBAF/LEFTY) in 1997. Dr tabibzadeh@bioscience.org
Tabibzadeh established Frontiers in
Bioscience journal in 1996 which is
now recognized as one of the top 50
biology journals in the world. Dr
Tabibzadeh founded the Frontiers in
Bioscience Research Institute in
Aging and Cancer in 2011 in pursuit
of finding a cancer cure and If you have a
pathway(s) to the reversal of aging. philanthropic
Dr Tabibzadeh is committed to
making the research institute to be nature, you
one of the pre-eminent research will enjoy
centers for excellence in science.
your
Selected Publications partnership
with us
Satyawaroop PG, Tabibzadeh S
Extracellular matrix and the patterns of
differentiation of human endometrial
carcinomas In vitro and In vivo.
Cancer Res 51:5661- 5666, 1991
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R Kothapalli, I Buyuksal, S-Q Wu, N JM Mason, Hao-Peng Xu, Srinivasa.
Chegini, S Tabibzadeh K. Rao, Andrew Leask, M Barcia,
Detection of EBAF, a novel human gene Jidong Shan, Robert Stephenson, S
of the TGF-beta superfamily; association Tabibzadeh
of gene expression with endometrial Lefty contributes to the remodeling of
bleeding. extracellular matrix by inhibition of CTGF
J Clin Invest 99, 2342-2350, 1997 and collagen mRNA expression and
http://www.jci.org/cgi/reprint/99/10/2342.pdf increased proteolytic activity in a
PubMed No 9153275 fibrosarcoma model.
J Biol Chem 4, 407-415, 2002
Tabibzadeh S, Mason J, Cai Y, Wendy http://www.jbc.org/cgi/reprint/277/1/407.pdf
S, Murray MJ, Lessey B
Dysregulated expression of EBAF, an Tabibzadeh S
occult and novel molecular defect in the Homeostasis of Extracellular Matrix By
endometria of patients with infertility. TGF-BETA and LEFTY
J Clin Endocrinol Metab 85, 2526- Front Biosci 7, d1231-1246, 2002
2536, 2000
http://jcem.endojournals.org/cgi/reprint/85/7/2526.pdf Li J, Kokkola R, Tabibzadeh S, Yang
doi:10.1210/jc.85.7.2526 R, Ochani M, Qiang X, Harris HE,
Czura CJ, Wang H, Ulloa L, Wang H,
Ulloa L, Creemers JW, Roy S, Liu S, Warren HS, Moldawer LL, Fink MP,
Mason J, Tabibzadeh S. Andersson U, Tracey KJ, Yang H.
Lefty proteins exhibit unique processing, Structural basis for the proinflammatory
and activate the MAP kinase pathway. cytokine activity of high mobility group
J Biol Chem 276, 21387-21396 box 1.
(2001) Mol Med. Jan-Feb;9(1-2):37-45.
http://www.jbc.org/cgi/reprint/M006933200v1.pdf 2003
doi:10.1074/jbc.M006933200
PMid:11278322 Tabibzadeh S, Hemmati-Brivanlou A
LEFTY at the crossroad of 'stemness' and
Ulloa L, Tabibzadeh S differentiative events.
Lefty inhibits R-Smad phosphorylation Stem Cells. 24, 1998-2006, 2006
induced by activated TGF-beta receptor doi:10.1634/stemcells.2006-0075
J Biol Chem 276, 21397-21404 PMid:16728558
(2001)
http://www.jbc.org/cgi/reprint/M010783200v1.pdf
doi:10.1074/jbc.M010783200
PMid:11278746
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Gaetan Mayer, Josee Hamelin,
Marie-Claude Asselin, Antonella
Pasquato, Edwidge Marcinkiewicz,
Meiyi Tang, Siamak Tabibzadeh, and
Nabil G. Seidah
The regulated cell-surface zymogen
activation of the proprotein convertase
PC5A directs the processing of its
secretory substrates.
J Biol Chem 283(4), 2373-2384.
2008
doi:10.1074/jbc.M708763200
PMid:18039650
Devendra G Naidu, Meiyi Tang,
Siamak Tabibzadeh
Lefty peptides, derived by MMP2
cleavage, act as a new class of
gelatinase A inhibitor.
Front Biosci 13, 7193-7201, 2008
Meiyi Tang, Devendra Naidu, Patrick
Hearing, Stuart Handwerger, and
Siamak Tabibzadeh
LEFTY, a member of the TGF-beta
superfamily, inhibits uterine stromal cell
differentiation. A novel autocrine role.
Endocrinology. 151, 1320-1330,
2010
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Daniel Tabibzadeh, a graduate of
Stony Brook University, obtained his
bachelor‟s degree in the biological
sciences in May of 2011. As an avid
follower of technology, Daniel
believes that the future of biology
will eventually become intertwined
with computer technology, in that
“biotechnology” will heavily
associate with computers and
ultimately artificial intelligence. As Daniel Tabibzadeh
such, Daniel has begun a new Development Manager
undertaking; to elevate the Frontiers Frontiers in Bioscience Research
in Bioscience journal to new heights Institute in Aging and Cancer
and also facilitate the “back-end” dan@bioscience.org
automation of various programming-
related methodologies of
manuscripts. Daniel acts as a
“consultant” for core decisions such
as Website re-design and other
major accords. Daniel will also
participate in the funding decisions
of FBS and ongoing activities at the
If you have a
research institute and will be
responsible for all budgetary philanthropic
matters. nature, you
will enjoy
your
partnership
with us
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Chris obtained his BS degree in
Genetics and Cell Biology from
University of Minnesota, Twin Cities,
MN in 1997 and received MS degree
in Biological Science from Illinois
State University, Normal, IL in 2002.
Chris succeeded in obtaining his PhD
degree in Biological Science from
University of California, Irvine, CA in
2008. Chris has participated as a
post-doctoral fellow from 2008 in Chris Wiley
the laboratory of Dr. Judith Campisi, Faculty, Science
one of the eminent scientists who is Frontiers in Bioscience Research
known for her ground breaking Institute in Aging and Cancer
discoveries at Buck Institute for taverus@gmail.com
Research on Aging. While working in
the Laboratory of Dr Campisi, Chris
discovered a novel link between
mitochondrial Sirtuin 3 and cell
senescence phenotypes including
regulation of arrest, morphology,
and secretion of inflammatory
cytokines and tissue remodeling If you have a
factors. This discovery links philanthropic
mitochondrial homeostasis to
nuclear gene expression through nature, you
multiple novel ROS-independent will enjoy
signaling pathways.
your
Chris joins the Frontiers in partnership
Bioscience Research Institute to
with us
continue his Landmark work, and
will continue to collaborate with Dr
Campisi and with scientists at SENS
who are working towards
mitochondrial DNA repair. Chris will
bring to the institute, an
unpublished mouse that allows
visualization of senescent cells in
tissues. Using this model, Chris will
participate in endeavors to reverse
aging.
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We are excited to have been able to Wiley, C.D., Matundan, H.H., Duselis,
recruit this promising scientist at A.R., Isaacs, A., and Vrana,
Frontiers in Bioscience Research P.B.
Institute on aging and cancer. Patterns of hybrid loss of imprinting
reveal tissue- and cluster-specific
Publications regulation.
PLoS One 3, e3572 (2008).
Duselis, A.R., Wiley, C.D., O’Neill,
M.J., and Vrana, P.B. Zishu, P., Sikandar, S., Witherspoon,
Genetic evidence for a maternal effect M., Dizon, D., Nguyen, T.,
locus controlling genomic imprinting and Bernischke, K., Wiley, C.D, Vrana,
growth. P.B., and Lipkin, S.M. Impaired
Genesis. 43, 155-65 (2005). Placental Trophoblast Lineage
Differentiation in Alkbh1(-/-) Mice.
Wiley, C.D. and Vrana, P.B. Dev Dyn. 237, 316-27(2008).
Mining the Peromyscus Genome: Early
Returns from the First Peromyscus BAC Kingsley, E.P., Manceau, M., Wiley,
Library. C.D., and Hoekstra, H.E.
Peromyscus newsletter. 41, 24-25 Melanism in peromyscus is caused by
(2007). independent mutations in agouti.
PLoS One. 4, e6435 (2009).
Matundan, H.H., Wiley, C.D., Nguyen,
Q.K., and Vrana, P.B.
Characterization & Transfection of
Peromyscus Embryonic Fibroblasts
(MEFs).
Peromyscus Newsletter. 41, 28-29
(2007).
Oriel R.C., Wiley, C.D., Dewey, M.J.,
and Vrana, P.B.
Natural Y Chromosome Variation
Modulates Stress & Diabetic Phenotypes.
Peromyscus Newsletter. 41, 21-23
(2007).
Oriel, R.C., Wiley, C.D., Dewey, M.J.,
and Vrana, P.B.
Adaptive Variation, Stress and Glucose
Regulation.
Dis Model Mech. 4-5, 255-263 (2008).
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Become part of Frontiers in Bioscience Research Institute
We invite you to participate in FBS research, fund raising and
educational programs and become a member of Frontiers in Bioscience
Research Institute. As a member, you will be qualified to be on our lifetime
roster of participants in our educational programs, receive beautiful artwork
for your contribution, and add the name of your family or institution in the
FBS Auditorium. The Auditorium is central to the activity of the Institute.
The FBS Auditorium serves as a valuable meeting place for the Institute
faculty, staff and guests. The Auditorium will also host members who will
participate in our educational programs and become aware of science in the
institute and witness the growth of scientists who are funded by their
generous contributions.
Each of the 120 seats in the Auditorium is available for sponsorship.
Sponsors may chose any available seat with a gift of $1,000-50,000 that
designates their permanent seat at the institute. An engraved nameplate
will be prominently affixed to a seat in this unique venue in our beautiful
newly designed building. These are our ways of saying thank you to your
generous support to one of the nation‟s first independent research institute.
We are dedicated and committed to understanding the means for aging
reversal and new non-toxic approaches for the treatment of cancer and
need your support to help you and humanity.
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Frontiers in Bioscience
Research Institute
16471 Scientific Way
Irvine, CA 92618
www.bioscience.org/ri.htm
fbs@bioscience.org
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Using the most modern research
advances, FBS Research Institute
will focus on reversal of the aging
process and in treating cancer by Funding Resarch
non-radiotherapeutic or
chemotherapy approaches. at FBS RI
Over the past several decades,
competing national priorities have
restricted the National Institutes of
Health (NIH), the primary federal
agency that funds biomedical
research to support diverse research
initiatives of scientists across the
US. For this reason, private support
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Philanthropic gifts to the Frontiers in
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lead to real change in biomedical
research aimed at extending the
healthy years of our lives and in
cancer treatment.
Gifts and private funds from
individuals, families, foundations and
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Bioscience Research Institute on an
accelerated pace of discovery.
Scientists at the institute have the Contact
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and identify new approaches before Frontiers in Bioscience Research Institute
they become eligible for NIH grant
support. These fundings will also Development
support the institute to recruit the
most talented scientists who are fbs@bioscience.org
committed to make Landmark
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Our Funding Priorities
Mission Statement
Support New Reversal of Aging Research Building
We plan to develop a clinic for aging reversal for the public. Our target date for
the construction of this facility is Jan 1, 2015. This is a clinic for implementation of
procedures that insure reversal of aging of the participants. Interested individuals can
send their letter of interest to us for participation in our endeavors and for reversal of
aging of their loved ones.
Support Foundation Grants
Research
Editorial Profile grants from foundations do not provide funding for indirect
administrative cost. Your support will supplement such funds that are generally not paid
by Research grant foundations.
Support Recruitment of New Scientific Faculty
During the past several decades, there has been a sharp decrease in the amount
of funds that support research in the US through National Institutes of Health (NIH).
Particularly, this has impacted young scientists who have the hope to helping humanity
but fail to secure funds for their research on aging and cancer. The average age of
funding has risen to 41 and the funding rate stands at a dismal rate (5-7%) in various
study sections of NIH. Great advancement in techniques in medicine, has made it
feasible to pursue and find breakthroughs that will change medicine in this decade. We
anticipate that by the year 2020-2030, many of human diseases including cancer and
FBS will be
aging, Delivers curable. However, finding such treatments require funding that currently
is not available through NIH or other funding agencies. Your contribution will make this
feasible. The Institute seeks to add 10 new Faculty positions by 2015 and will need to
spend $2 - $3 million to recruit, equip, and provide the initial support for each of the
new scientist. Similar funds not available from granting agencies and private funds are
required to start new scientists on their road of discovery. A gift of $2.5 million entitles
the donor to name the position in perpetuity (“Endowed Professorship”).
Support of New “High-Risk, High-Payoff” Research Initiatives
Federal granting agencies, by nature, only fund research proposals that are low
risk but these research endeavors add only marginally to science when executed to
their completion. Most advances in medicine, however, have occurred through private
contributions that support “high risk” but “high pay-off” research. The Institute actively
seeks contributions for support of these “high-risk” approaches that are likely to bring
sweeping changes in medicine. Among them are approaches for non-radiotherapeutic
and non-chemotherapy approaches for treatment of cancer and aging reversal that are
not currently funded by NIH or other Federal agencies due to their high risk nature.
Support of Student Science Education
The Institute actively seeks gifts, and other forms of contributions and corporate
sponsorships to educate talented students who consider science research as a possible
career goal. Your contribution will support such gifted individuals to find their way in Support us
research and allow us to train them to be future scientists.
Frontiers in Bioscience
Support of Community Education in Aging and Cancer Research Institute 16471
Scientific Way
The Institute hosts highly popular and thought provoking Seminars in a wide
Irvine, CA 92618
array of subjects but particularly those that address treatment of cancer or reversal of
aging. Institute scientists and highly recognized external scientists will deliver their
work on cutting edge technology, and breakthroughs in medicine and research on aging
and cancer in our quarterly lectures in the FBS Auditorium. The Institute seeks gifts and
corporate sponsorships in support of these Lecture series and highly exceptional
educational programs.
Support for Purchase of scientific equipments
Your gift goes a long way to allow us to continue to purchase expensive research
equipments that are difficult to purchase with Federal grants. Such equipments are
required for our research that uses such equipment for data generation or for data
mining and analysis
fbs@bioscience.org
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How to donate to Frontiers in Bioscience Research Institute
Donate by mail
You can send us check, or any form of payment
(credit card, money order, security such as stock,
bond, mutual fund or other equities, land, or any
form of transferrable asset). Please send us your
contribution with a letter describing your specific
interest in donating to special fund raising requests of
FBS (Aging research, Cancer Research, Educational
program or becoming a member). Please also provide
us with your full name, address and contact
information including your phone number and Email.
You will be contacted upon receipt of the fund and we
will invite you to join us for a tour of the Research
Institute. During this tour, you can choose from arts
at the institute or you can go online to the gallery
WebSite, choose the art that is consistent with the
level of your donation and the art will be sent to the
address you specify in your letter. If you are not
interested in the art work displayed at the institute or
online, we offer you other gifts including travel
expenses or you can choose from an inventory of
gifts that are available to our donors. If you prefer
contact us by Email first so that we can contact you
to help you towards your donation process.
Contact us
Please mail your donation and letter of interest to
Frontiers in Bioscience Research Institute in Aging
and Cancer
16471 Scientific Way
Irvine CA 92618
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fbs@bioscience.org
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16471 Scientific Way, Irvine CA 92618
Accelerate science by volunteering
Become a Volunteer at the institute
Volunteering is integral to the success of our mission
to reverse aging and provide treatment for all human
solid cancers. The Institute greatly values and will be
indebted for contribution of all those who wish to
provide us with their time, support, and expertise.
The institute offers a diverse array of volunteering
opportunities. You can help us in direct research, or
provide us with administrative assistance or extend
your help in any other form such as fund raising,
educational programs that you find suitable. Most
people are able to provide support at many different
levels. Please contact us if you like to participate in
our mission and endeavors. We would be happy to
discuss with you the type of help that you wish to
extend to this institution.
Current Opportunities:
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For more information about current opportunities or
to learn more about our volunteering program,
please contact: fbs@bioscience.org
Help us to Help You and Your Loved ones
Enrich your life with beautiful art
Your tax deductible contribution will support research in aging and cancer. All of us
age and most of us have a family member who has cancer or develops cancer as
they age. Your contributions will fuel research at Frontiers in Bioscience Research
Institute and you are invited to visit our laboratories to see the progress that we
are making towards the treatment of cancer, and slowing or reversing aging. You
will receive an artwork made by well known artists that can be viewed within the
institute or at the Gallery WebSites. The artwork is our way of thanking you for your
generosity in supporting our mission and initiatives.
All arts at the institute carry special colored tags identifying the artwork that is
received for each contribution.
Donate and
receive an
artwork to
be cherished
for a lifetime
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Mandarin Fine Art Gallery
Mandarin Fine Art Gallery features
an eclectic selection of Chinese
Contemporary Art. All of the artists
represented are world-class
emerging and mid-career artists
currently living in China and Tibet.
The styles range from realism to
expressionism, and from surrealism
to abstract. With tremendous talent
and deep intriguing conceptual
framework, these artists create
magnificent arts pertinent to the
modern day China and China's
relation to the world. The subject
matter varies from Chinese urban
scenes to the most remote and
isolated places such as Tibet and
Liangshan. With artwork that is
refreshingly thought-provoking,
aesthetically appealing, and
If you love
culturally relevant, Mandarin Fine Art art, you love
Gallery is committed to bringing the
finest Chinese Contemporary Art to
arts from
America and the Western World. Mandrin Fine
Art Gallery
Mandarin Fine Art Gallery
www.mandarinfineart.com
john@mandarinfineart.com Receive a
949-376-9608
beautiful
piece of art
as a gift
today.
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Kamran Khavarani Art,
Abstract Romanticism
Early life
Born into an artistic family,
Khavarani started painting at a very
young age. When he was twelve
years old, he began to study
classical painting with the well-
known artist, Reza Samimi.
Khavarani completed his education
in 1966 from Tehran University with
a Master‟s degree in Architecture
and a Ph.D. in Urban Design. His
graduate work was done under the
guidance of his mentor Master,
Hooshang Seyhoun, the
internationally renowned Iranian
authority in art and architecture
Influences
If you love
Khavarani‟s earlier paintings were art, you love
influenced by his classical and formal
training in arts and architecture.
arts from
Since his recent encounters with the Kamran
philosophy of Rumi and other great Khavarani
teachers, both the artist and his art
have been transformed and his Art Gallery
current paintings carry subtle
mystical messages.
Receive a
Kamran Khavarani‟s paintings piece of art
represent a rare fusion of the
philosophical and metaphysical with
as a gift
the aesthetic, and they draw viewers today.
into the inner world. Professor
Boime wrote about Khavarani in his
last book;
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“The Birth of Abstract Romanticism:
Art for a New Humanity, Rumi and
the Paintings of Kamran Khavarani‟:
“Exalted by the love poems of the
Persian poet Jalaluddin Rumi (1207-
73), Khavarani seeks to translate his
ecstatic feelings into visual
harmonies that celebrate the idea of
Presence, the loving, creative side of
existence potentially in everything
and everyone.”
In The Birth of Abstract
Romanticism, Professor Boime
explored the details and effects of
the artist‟s style: “… Khavarani
visually expresses his inner response
to Rumi, evoking the oceanic and
cosmic metaphors of the Persian
mystic…Assigning to each of the four
elements (earth, air, fire and water)
If you love
its own unique color register, he art, you love
gives his primordial visions - most
arts from
evident in his glowing 'Creation'
(2003) - a riveting presence. His Kamran
skies and seas are saturated in Khavarani
unprecedented, emotional blue-
greens, purples and oranges, and his Art Gallery
mountain forms are often
surrounded by a web of shadowy
halos that convey a misty sensory
Receive a
impression of a world still in piece of art
formation.”
as a gift
today.
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In an open letter on July 28, 2008,
Professor Boime wrote: “…Khavarani
resurrects the romantic possibility
that art can change the world by
reaching out unstintingly to the
heart and imagination of the
individual spectator.” As Professor
Boime wrote in the conclusion of The
Birth of Abstract Romanticism, “It
remains to be seen how the fallout
from Khavarani‟s painting will
influence the history of art. Certainly
his work goes against the grain of
most international contemporary art
and in fact purports to offer an
alternative to it…„Beauty‟ is certainly
the key word in Khavarani‟s lexicon,
as it represents the quality he has
made it his life‟s ambition to
express—a harmonizing force to
offset the „ugliness‟ of so much
If you love
bacchanalian and barbaric display art, you love
that presently passes for art.”
arts from
Kamran
Khavarani
Art Gallery
Receive a
piece of art
as a gift
today.
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Technique
Khavarani paints with his hands
encased in plastic gloves and by
working flatly in oil on paper. He
uses his whole hand, in almost
dancing motion, and one barely
detects the tracks of his labor. As
Professor Boime wrote in his book,
Khavarani “… has perfected this
unique method that produces
remarkable results, even at the
micro level.”
Awards
Khavarani has won numerous
architectural awards such as
„California Building Official‟s highest
award of excellence‟ for a single
family residence, and the design
award for the city of Beverly Hills in
a commercial category. His “art- If you love
scaping” design has been recognized art, you love
and published in Japan‟s most
prestigious landscaping magazine for arts from
three consecutive years. Kamran
Kamran Khavarani Art Gallery
Khavarani
www.khavarani.com Art Gallery
310-650-7726 Cell
kamran@khavarani.com
Receive a
piece of art
as a gift
today.
Donate to Frontiers in Bioscience Research Institute
Frontiers in
Bioscience
Research Institute
16471 Scientific
Way
Irvine CA 92618
Contact us
fbs@bioscience.org