Liver

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					                            Liver


Liver
                                           Normal

                                          Pathology

              General Features                            Infectious Diseases


           Autoimmune Hepatitis                              Drugs & Toxins

           Alcoholic Liver Disease                      Metabolic Liver Disease


         Intra Hepatic Biliary Diseases                  Circulatory Disorders


        Hepatic disease- Pregnancy                    BM Transplantation – Hepatic Disease



                                           Tumors
Circulatory Disorders

              A




              B




              c
• A. Hepatic vein outflow obstruction
• 1. Budd-Chiari syndrome =Hepatic vein & IVC thrombosis
   – Seen in Thrombotic conditions (polycythemia vera, pregnancy and the
     postpartum state, oral contraceptive use, PNH and intra-abdominal
     cancers - ex. hepatocellular carcinoma)
   – Membranous webs of IVC may give rise to obstruction
   – Characterized by Hepatomegaly, Ascites & abdominal pain




                                         • Thrombosis of the major
                                           hepatic veins
                                         • extreme blood retention
                                           in the liver
• 2. Veno-Occlusive Disease= Jamaican bush tea (pyrrolizidine alkaloid), but
  now MC seen in bone marrow transplant recipients
   – Clinically= similar to Budd-Chiari syndrome



                                          • marked deposition of
                                          collagen within the lumen
                                              of the central vein



B. Impaired Intra – hepatic Blood flow
    •MCC = cirrhosis
    •Other causes DIC (Eclampsia), sickle cell disease, Sarcoidosis
    •Passive Congestion and Centrilobular Necrosis
Peliosis Hepatis = dilation of hepatic sinusoids
    •Exposure to anabolic steroids (rarely OCP and Danazol)
    •liver is mottled and blotchy with irregular blood-filled lakes
C. Impaired hepatic Blood in-flow
    •Portal vein obstruction
    •Thrombus
        B – Nutmeg                         C- Infarct




• Centrilobular hemorrhagic   • A thrombus is lodged in a
  necrosis. (Nutmeg liver).     peripheral branch of the
                                hepatic artery

				
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posted:12/9/2011
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