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147

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									  TINU SYNDROME AND ANTIPHOSPHOLIPID ANTIBODIES
C. Belizna1 J-M. Woehl2 B. Woehl-Kremer2 J-L. Wiederkehr2 G. Blaison2
       1
           CHU Hotel Dieu, Nantes, 2Hopital Colmar, Colmar, France
Acute tubulointerstitial nephritis and uveitis (TINU syndrome) is a rare
disease presumed as immune. We present two revealing cases. The first
one is that of a 35 y o female patient who was admitted in july 1999 in our
clinic with acute renal failure(serum creatinin levels 364 umol/l),
inflammatory syndrome, and anterior uveitis. Few months earlier(may
1999) she had a partial thyroidectomy for adenoma, and since then she
presented fatigue, weight loss, nausea, pollakiuria, polydipsia. The second
report concerns a 32 y. o. female patient admitted in may 2001 with acute
renal failure, associated in her case with hepatic cholestasis, anemia and
anterior uveitis, developed in two weeks time after thyroidectomy.
Percutaneous renal biopsy revealed for both patients eosinophilic
infiltration of renal interstitium, and made the diagnosis of TINU
syndrome. Renal failure responded to systemic steroid treatment and
uveitis to topical steroids. Anticardiolipin antibodies and lupus
anticoagulant were positive in both cases, on several determinations.
Humoral immunity seems to play a role in the etiology of this disease
where cell mediated immune process are presumed. We summarise the
present knowledge and our own onsideration in this field. Furhermore, we
report two new cases of hyperthyroidism as being a new feature of TINU
syndrome.




Abstract Number: 147
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