Jason Anthony Deck
RESIDENCE: 4523 Cheltenham Dr
Bethesda, MD 20814
Phone: 512-699-5358
Email: jadeck@gmail.com
TITLE: Post Doctoral Intramural Research Training Awardee
Drug Design and Synthesis Section
Chemical Biology Research Branch
National Institute on Drug Abuse
National Institutes of Health
5625 Fishers Ln, Rm 4N-03, MSC 9415
Bethesda, MD 20892-9415
Phone: 301-435-1922
Fax: 301-402-0589
Email: deckj@nida.nih.gov
Website: www.jasondeck.com/career
CITIZENSHIP: United States Citizen
EDUCATION: PhD, Organic Chemistry, University of Texas at Austin, Austin, TX,
May 2007
Advisor: Professor Stephen F. Martin
Dissertation: “Studies Towards the Total Synthesis of
Condylocarpine and Studies Towards the Enantioselective
Synthesis of (+)-Methyl Lysergate”
MS, Organic Chemistry, University of New Mexico, Albuquerque, NM,
June 2000
Advisor: Professor David L. Vander Jagt
BS, Chemistry, Fort Lewis College, Durango, CO, June 1997
OTHER TRAINING: Principles of Clinical Pharmacology – NIH Clinical Center‟s Office of
Clinical Research Training and Medical Education (OCRTME)
Pharmacology – Foundation for Advanced Education in the Sciences
(FAES), NIH
Gordon Research Conference on Natural Products, 2010
9th Annual Florida Heterocyclic and Synthetic IUPAC-Sponsored
Conference (FloHet IX)
Searching the Beilstein Database with Crossfire/Reaxys – NIH Library
Searching the Chemical Abstracts Service (CAS) database with
SciFinder – NIH Library
Endnote Bibliography Software – UT Austin Library
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PROFESSIONAL EXPERIENCE:
6/07 – Present: Postdoctoral Fellow IRTA, National Institute on Drug Abuse, Bethesda
and Rockville, MD
Advisor: Dr. Kenner C. Rice
Designed and synthesized novel phenylmorphans to evaluate as
potential high affinity ligands for selective opioid receptors and
analgesics. Identified critical parameters and optimized synthetic route
for chromatography free scale up and production of 5-(3-
methoxyphenyl)-2-methyl-9-oxo-2-azabicyclo[3.3.1]nonane.
8/00 – 5/07: Graduate Assistant, University of Texas at Austin, Austin, TX
Advisor: Professor Stephen F. Martin
Performed synthetic studies towards the total synthesis of the polycyclic,
cage like, indole alkaloid natural product condylocarpine via a dual
cyclization cascade.
Completed the first enantioselective total synthesis of the ergot alkaloid
natural product (+)-isolysergol featuring an unprecedented late stage
microwave mediated asymmetric ring closing metathesis (ARCM).
5/98 – 7/00: Graduate Assistant, University of New Mexico, Albuquerque, NM
Advisor: Professor David L. Vander Jagt
Designed and synthesized non-natural products as inhibitors of lactate
dehydrogenase (LDH) enzymes from the malaria parasite P. falciparum,
and protozoan parasite T. gondii.
Synthesized and characterized (via 2d-multinuclear NMR spectroscopy)
the moderately complex multicyclic heterocycles 2-thienyl-4(3H)-
quinazolinones.
Designed and implemented NMR spectroscopy lab course for organic
laboratory II with both practical instrument use and web based „canned‟
NMR assignments.
5/97 – 11/97: Lab Technician, University of New Mexico, Albuquerque, NM
Supervisor: Professor David L. Vander Jagt
Designed and modeled inhibitors of lactate dehydrogenase (LDH)
enzymes from both humans and the malaria parasite P. falciparum.
Synthesized dihydroxynaphthoic acids structurally related to the
cottonseed oil derived natural product gossypol for LDH inhibition
studies.
6/96 – 9/96: Summer Internship, University of New Mexico, Albuquerque, NM
Supervisor: Professor Mark J. Hampden-Smith
Synthesized organoindium compounds as potential window glass coating
precursors.
6/95 – 6/96: Undergraduate Research, Fort Lewis College, Durango, CO
Supervisor: Professor Irwin (Ike) L. Klundt
Synthesized pyrrole precursors for use as singlet oxygen traps.
TECHNICAL SKILLS:
Synthesis
Multistep organic and organometallic synthesis.
Bench top and air sensitive techniques.
Milligram to multigram scale.
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Asymmetric enantioselective synthesis.
Optical resolution via chiral salts.
Chiral HPLC.
Compound Isolation and purification
Flash chromatography
HPLC
Distillation
Recrystallization
Sublimation
Liquid-liquid extraction
TLC
Preparative TLC
Radial chromatography
Compound Identification/Spectroscopy
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NMR spectroscopy: H, C, COSY, HMQC, HMBC, NOESY,
VT, etc.
FT-IR
LRMS, GC-MS, HRMS
TLC
Chiral HPLC
Optical rotation
Computer skills
Windows, Mac OS, Linux, MS Office, ChemOffice, ISIS, MDL
Crossfire/Reaxys, SciFinder, Waters‟ Breeze and Empower,
Photoshop, GIMP, HTML/webpage construction and
deployment, internet and database searching
LEADERSHIP/MENTORSHIP:
Invented, prepared, and developed new chemical products utilizing
advanced chemical knowledge, data, modeling and statistical tools to
solve technical challenges.
Served as a team leader and advisor to other scientists.
Trained and supported chemists in instrument use and bench
techniques.
Purchased, set up, and maintained laboratory equipment, including
instruments such as HPLC, and trained researchers in their use.
Provided expert advice to other chemists on sampling, and instructed
other laboratory personnel in analysis techniques.
Strong interpersonal skills, and excellent organizational and
communication (written and verbal) skills.
Developed and implemented group meeting schedule to foster
communication between researchers.
Edited technical documents for content, grammar, and language for both
native and non-native English speakers.
Documented, interpreted and communicated results to colleagues and
supervisors.
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Prepared summaries and reports addressing problems, deficiencies,
corrective actions taken, and recommendations for strengthening and
improving programs.
Worked both independently and cooperatively in a multidisciplinary
environment, collaborating with colleagues to develop innovative new
technology.
Attended technical meetings, read relevant reports and publications, and
provided technical assistance to researchers, supervisors, and the
public.
Lecture teaching assistant for organic 1 and 2.
Lab teaching assistant for general chemistry 1 and organic 2.
Designed and implemented NMR spectroscopy lab course for
undergraduates including web based assignments, UNM 1998-2000.
Directed the research of undergraduate students, UNM 1997-2000.
Fort Lewis College Chemistry Club, president, 1996-1997.
MEMBERSHIP IN PROFESSIONAL SOCIETIES:
1996 – Present American Chemical Society
2007 – Present Texas Exes, University of Texas alumni association
AWARDS AND OTHER SPECIAL RECOGNITION:
Dean's Excellence Award – UT Austin, 2000
Army Corps of Engineers Pre-Doctoral Fellowship – UNM, 1999
Clark Graduate Teaching Award – UNM, 1997
ORAL PRESENTATIONS:
“Enantioselective synthesis of (+)-isolysergol via ring closing metathesis”,
American Chemical Society Fall National Meeting, Boston, MA, 8/2010.
“Synthesis and structure-activity relationship of 5-(3-
hydroxy)phenylmorphans: Probes for narcotic receptor mediated
phenomena”, American Chemical Society Fall National Meeting,
Philadelphia, PA, 8/2008.
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PUBLICATIONS:
Deck, J. A.; Rice, K. C. Synthesis and structure-activity relationship of 5-(3-
hydroxy)phenylmorphans: Probes for narcotic receptor mediated
phenomena. In Preparation.
Deck, J. A.; Martin, S. F. Enantioselective Total Synthesis of (+)-Isolysergol
via Asymmetric Ring Closing Metathesis. Organic Letters 2010, 12, 11, 2610-
2613.
Lee, S. B.; Park, J. H; Folk, J. E.; Deck, J. A.; Pegg, A. E.; Sokabe, M.;
Fraser, C. S.; Park, M. H. Inactivation of Eukaryotic Initiation Factor 5A
(eIF5A) by Specific Acetylation of its Hypusine Residue by
Spermidine/Spermine Acetyltransferase 1 (SSAT1). Submitted.
Kruiswijk, E.; Deck, J. A. Synthesis of Ammonium Compounds including N-
Ylides. In Science of Synthesis; Enders, D. Ed.; Vol 40; Georg Thieme
Verlag, 2008.
Assisted in editing “The Comprehensive E-book of named organic reactions
and their mechanisms” by E. Kruiswijk, edition 2.1
(www.namedorganicreactions.co.uk).
Stoddard Hatch, M.; Brown, W. M.; Deck, J. A.; Hunsaker, L. A.; Deck, L. M.;
Vander Jagt, D. L. Inhibition of yeast lipase (CRL1) and cholesterol esterase
(CRL3) by 6-chloro-2-pyrones: comparison with porcine cholesterol esterase.
Biochimica et Biophysica Acta 2002, 1596(2), 381-391.
Yu, Y.; Deck, J. A.; Hunsaker, L. A.; Deck, L. M.; Royer, R. E.; Goldberg, E.;
Vander Jagt, D. L. Selective active site inhibitors of human lactate
dehydrogenases A4, B4, and C4. Biochemical Pharmacology 2001, 62(1),
81-89.
Deck, L. M.; Turner, S. D.; Deck, J. A.; Papadopoulos, E. P. Synthesis of
derivatives of thiophene using methyl 2-isothiocyanatobenzoate. Journal of
Heterocyclic Chemistry 2001, 38(2), 343-347.
POSTER PRESENTATIONS:
“Studies Towards the Enantiocontrolled Total Synthesis of (+)-Methyl
th
Lysergate”, Stephen F. Martin 60 Birthday Symposium, University of Texas
at Austin, 2006.
“Dihydroxynaphthoic Acids as Inhibitors of Lactate Dehydrogenase”, Sevilleta
Research Symposium, Sevilleta National Wildlife Refuge, NM, 2000.
“Pan-active Site Inhibition: Inhibitor Specificity Through Competitive Binding
at both Substrate and Cofactor Sites”, Sevilleta Research Symposium,
Sevilleta National Wildlife Refuge, NM, 2000.
“Pancreatic Cholesterol Esterase: a Potential Drug Target in the Treatment of
Heart Disease and the Development of Selective Inhibitors”, Sevilleta
Research Symposium, Sevilleta National Wildlife Refuge, NM, 2000.
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“Synthesis of Selective Inhibitors of Cholesterol Esterase”, Sevilleta
Research Symposium, Sevilleta National Wildlife Refuge, NM, 1999.
“Synthesis of Selective Inhibitors of Lactate Dehydrogenases”, Sevilleta
Research Symposium, Sevilleta National Wildlife Refuge, NM, 1999.
“Dihydroxynaphthoic Acids: A New Class of Active Site Dehydrogenase
Inhibitors.”, Annual Meeting of the American Society for Biochemistry and
Molecular Biology and Satellite Meetings, Washington, DC, 1998.
REFERENCES: Dr. Kenner C. Rice
Chief, Drug Design and Synthesis Section
Chief, Laboratory of Medicinal Chemistry
National Institute on Drug Abuse, National Institutes of health
Phone: 301-496-1856
Email: kennerr@nida.nih.gov
Professor Stephen F. Martin
M. June and J. Virgil Waggoner Regents Chair in Chemistry
Department of Chemistry & Biochemistry
The University of Texas at Austin
Phone: 512-471-3915
Email: sfmartin@mail.utexas.edu
Professor David L. Vander Jagt
Department of Biochemistry & Molecular Biology
The University of New Mexico
Phone: 505-272-5788
Email: dlvanderjagt@salud.unm.edu
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