From Wikipedia, the free encyclopedia AVI BioPharma
AVI BioPharma
AVI BioPharma Inc. NASDAQ: AVII is a medical research Virus, SARS, Hepatitis C, dengue fever, Ebola and Cali-
and drug development company with corporate offices civirus, all of which are single stranded RNA viruses.
and research facility in Bothell, Washington, United However, clinical studies have not demonstrated signifi-
States. Incorporated in 1980, the company maintains cant effects in humans and there are no approved drugs
some laboratory capability in Corvallis, Oregon. As of in this class.
2008, the company has 170 issued medical patents, and In addition to development of Morpholinos as ther-
over 150 patents pending.[1] apeutics, AVI has conducted six human trials for col-
orectal and pancreatic cancers using their cancer vaccine
History AVICINE.
AVI BioPharma opened their own production laboratory
in Corvallis, Oregon, in February 2002.[2] The company
References
made headlines in 2003 when it announced work on [1] AVI BioPharma official website
treatments for SARS and the West Nile Virus.[2][3] In July [2] ^ Moody, Robin J. (November 5, 2003). "AVI
2009, the company announced they would move their BioPharma’s losses shrinking". Portland Business
headquarters from Portland, Oregon, north to Bothell, Journal. http://portland.bizjournals.com/portland/
Washington, near Seattle.[4] At that time the company stories/2003/11/03/daily20.html. Retrieved
led by president and CEO Leslie Hudson had 83 employees 2009-10-24.
and quarterly revenues of $3.2 million.[4] AVI had yet [3] Moody, Robin J. (June 12, 2003). "AVI BioPharma
to turn a profit nor developed any commercial products stock reaches new 52-week high". Portland Business
as of July 2009.[4] The company lost $19.7 million in the Journal. http://portland.bizjournals.com/portland/
second quarter of 2009,[5] and then won a $11.5 million stories/2003/06/09/daily40.html. Retrieved
contract with the U.S. Department of Defense’s Defense 2009-10-24.
Threat Reduction Agency in October 2009.[6] The compa- [4] ^ DiMesio, Robbie (July 30, 2009). "AVI BioPharma
ny had completed its move to Bothell by this time, but re- moving HQ out of Oregon". The Oregonian.
tained their Corvallis facility.[4][6] http://www.oregonlive.com/business/index.ssf/
2009/07/avi_biopharma_moving_hq_out_of.html.
Products [5]
Retrieved 2009-10-24.
"AVI BioPharma loses $19.7M in Q2". Portland
Its primary products are Morpholino oligos (PMOs), con- Business Journal. August 10, 2009.
ceived of by James Summerton and invented by Summer- http://portland.bizjournals.com/portland/stories/
ton with Dwight Weller, being developed under the name 2009/08/10/daily2.html. Retrieved 2009-10-24.
NeuGene Antisense. This form of antisense therapy uses [6] ^ "AVI BioPharma gets $11.5M military contract".
a synthetic structural analog of RNA to bind to the mes- Portland Business Journal. October 5, 2009.
senger RNA produced by a known disease-causing gene http://portland.bizjournals.com/portland/stories/
strand and thus deactivate it. 2009/10/05/daily1.html. Retrieved 2009-10-24.
Morpholinos have been tested for a wide range of
applications including prevention of cardiac restenosis
after angioplasty, treatment of coronary artery bypass
External links
grafts, treatment of polycystic kidney disease, and redi- • AVI BioPharma drops two directors, shareholder
rection of drug metabolism. Morpholinos have been used group to dissolve - Portland Business Journal
in preclinical studies to inhibit replication of West Nile
Retrieved from "http://en.wikipedia.org/w/index.php?title=AVI_BioPharma&oldid=413550888"
Categories:
• Companies listed on NASDAQ
• Companies based in Washington (state)
• Pharmaceutical companies of the United States
• Companies established in 1980
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From Wikipedia, the free encyclopedia AVI BioPharma
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