Nanobiotechnology Based Tissue Engineering in Microgravity

							Nanobiotechnology Based Tissue
  Engineering in Microgravity

           Peter I. Lelkes
  Calhoun Chair Professor in Cellular
         Tissue Engineering

   School of Biomedical Engineering,
      Science and Health Systems
   Neural Cells, Cell Aggregates,
 Functional Neuroendocrine Tissues




                                                                    75 m


2-D TC-Plate        Static 3D-Aggregates        Dynamic 3-D Bioreactors

 •To date: participation in 5 space missions, tissue assembly
  and differentiation in space / microgravity
 •Next flight tentatively scheduled for early 2006
    Gravitational Biology / Nanobiotechnology:
       Applications for Tissue Engineering

Progenitor / Stem Cells + Intelligent Nanofibrous Scaffolds
                                 / Nano-Biotechnology


                             Ground-Based Microgravity Analog:
                             Rotating Wall Vessel Biotechnology
                             (NASA)




   •Functional Replacement Tissues
   •Model Tissues for Basic and Clinical Research
   • Analysis and Modeling: Functional Bioinformatics
 Cells/Tissues Growing on/in Nanotechnology-
           Based Intelligent Scaffolds

               Electrospinning


                                         Lung




                                         Heart




Neuronal Cells on PLA scaffolds
Possible Involvement of LM in [NanoBio -
 Based] Space Exploration Technology :
    Design of Innovative Ground-Based Microgravity Analogs
     and Flight Hardware
    Development of Novel Capabilities for Remote (Robotic)
     Manipulation, Sensing and Data Collection
    Development of Novel Nanotechnology-Based Materials:
        Smaller, Lighter

    Leverage of High-Throughput Capabilities for Computational
     Biology:
        Modeling the Role of Nanobiotechnology for Tissue Assembly in
         Microgravity: Genomics, Proteomics