From Wikipedia, the free encyclopedia HOTAIR
HOTAIR
Hox transcript antisense RNA (non-protein coding) References
Identifiers [1] "Genecards entry on HOTAIR".
Symbols HOTAIR; FLJ41747; HOXAS; HOXC11-AS1; http://www.genecards.org/cgi-bin/
NCRNA00072 carddisp.pl?gene=HOTAIR. Retrieved 20 July 2010.
[2] Petherick A (August 2008). "Genetics: The
External IDs OMIM: 611400 GeneCards: HOTAIR Gene
production line". Nature 454 (7208): 1042–5.
doi:10.1038/4541042a. PMID 18756228.
Orthologs
[3] ^ Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X,
Species Human Mouse Brugmann SA, Goodnough LH, Helms JA, Farnham
PJ, Segal E, Chang HY (June 2007). "Functional
Entrez 100124700 n/a
demarcation of active and silent chromatin
Ensembl ENSG00000228630 n/a domains in human HOX loci by noncoding RNAs".
UniProt n/a n/a Cell 129 (7): 1311–23. doi:10.1016/j.cell.2007.05.022.
PMC 2084369. PMID 17604720.
RefSeq NR_003716 n/a http://www.pubmedcentral.nih.gov/
(mRNA)
articlerender.fcgi?tool=pmcentrez&artid=2084369.
RefSeq n/a n/a [4] ^ Tsai MC, Manor O, Wan Y, et al. (August 2010).
(protein) "Long noncoding RNA as modular scaffold of
Location Chr 12: n/a histone modification complexes". Science 329
(UCSC) 54.36 – 54.37 Mb (5992): 689–93. doi:10.1126/science.1192002.
PMC 2967777. PMID 20616235.
PubMed [1] n/a
search
http://www.pubmedcentral.nih.gov/
articlerender.fcgi?tool=pmcentrez&artid=2967777.
HOTAIR (for HOX antisense intergenic RNA)[1] is a gene at [5] Chuong CM (January 2003). "Homeobox genes, fetal
12q13.13 size 6,232 bp encoding 2.2 kbp long noncoding wound healing, and skin regional specificity". J.
RNA molecule, which controls gene expression on chro- Invest. Dermatol. 120 (1): 9–11. doi:10.1046/
mosome 2. Its source DNA is located within a HOXC gene j.1523-1747.2003.00002.x. PMID 12535191.
cluster. It is the first example of an RNA expressed on [6] Gupta RA, Shah N, Wang KC, et al. (April 2010).
one chromosome influencing transcription on another "Long non-coding RNA HOTAIR reprograms
chromosome. It is shuttled from chromosome 12 to chro- chromatin state to promote cancer metastasis".
mosome 2 by the Suz-Twelve protein.[2] The 5’ end of Nature 464 (7291): 1071–6. doi:10.1038/nature08975.
HOTAIR interacts with a Polycomb-group protein Poly- PMC 3049919. PMID 20393566.
comb Repressive Complex 2 (PRC2) and as a result regu- http://www.pubmedcentral.nih.gov/
lates chromatin state. It is required for gene-silencing of articlerender.fcgi?tool=pmcentrez&artid=3049919.
the HOXD locus by PRC2.[3][4] The 3’ end of HOTAIR inter-
acts with the histone demethylase LSD1.[4] Further reading
It is an important factor in the epigenetic differen-
• Woo CJ, Kingston RE (June 2007). "HOTAIR lifts
tiation of skin over the surface of the body. Skin from
noncoding RNAs to new levels". Cell 129 (7): 1257–9.
various anatomical positions is distinct, e.g. the skin of
doi:10.1016/j.cell.2007.06.014. PMID 17604716.
the eyelid differs markedly from that on the sole of the
• Khalil AM, Guttman M, Huarte M, et al. (July 2009).
foot.[3][5]
"Many human large intergenic noncoding RNAs
HOTAIR is highly expressed in metastatic breast can-
associate with chromatin-modifying complexes and
cers. High levels of expression in primary breast tumours
affect gene expression". Proc. Natl. Acad. Sci. U.S.A. 106
are a significant predictor of subsequent metastasis and
(28): 11667–72. doi:10.1073/pnas.0904715106.
death.[6]
PMC 2704857. PMID 19571010.
http://www.pubmedcentral.nih.gov/
articlerender.fcgi?tool=pmcentrez&artid=2704857.
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From Wikipedia, the free encyclopedia HOTAIR
• Wan Y, Chang HY (September 2010). "HOTAIR: Flight ncRNA". Genes Dev. 24 (23): 2615–20. doi:10.1101/
of noncoding RNAs in cancer metastasis". Cell Cycle 9 gad.1983810. PMC 2994035. PMID 21123648.
(17): 3391–2. PMC 3066151. PMID 20864820. http://www.pubmedcentral.nih.gov/
http://www.pubmedcentral.nih.gov/ articlerender.fcgi?tool=pmcentrez&artid=2994035.
articlerender.fcgi?tool=pmcentrez&artid=3066151. • Sun L, Fang J (January 2011). "Writer meets eraser in
• Hung T, Chang HY (September 2010). "Long HOTAIR". Acta Biochim. Biophys. Sin. (Shanghai) 43 (1):
noncoding RNA in genome regulation: Prospects and 1–3. doi:10.1093/abbs/gmq110. PMID 21138898.
mechanisms". RNA Biol 7 (5): 582–5. PMC 3073254. • Yang Z, Zhou L, Wu LM, et al. (February 2011).
PMID 20930520. "Overexpression of Long Non-coding RNA HOTAIR
http://www.pubmedcentral.nih.gov/ Predicts Tumor Recurrence in Hepatocellular
articlerender.fcgi?tool=pmcentrez&artid=3073254. Carcinoma Patients Following Liver
• Kaneko S, Li G, Son J, et al. (December 2010). Transplantation". Ann Surg Oncol 18 (5): 1243–1250.
"Phosphorylation of the PRC2 component Ezh2 is cell doi:10.1245/s10434-011-1581-y. PMID 21327457.
cycle-regulated and up-regulates its binding to
Retrieved from "http://en.wikipedia.org/w/index.php?title=HOTAIR&oldid=456193047"
Categories:
• Human proteins
• Antisense RNA
• Non-coding RNA
• Chromosome 12 gene stubs
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