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Sheet1 NCI Wiki

VIEWS: 7 PAGES: 44

									Concept                       Synonym     CUI      Note                 Concantenation         Concanten Definition                                            Form      Question
                                                                        Values Only            ation                                                                     Number
                                                                                               Formula


11q23                                     C13390                        C13390 (11q23 )        C13390        A chromosome band present on 11q
                                                                                               (11q23 )




12p                                       C13532                        C13532 (12p)           C13532        Proximal (short) arm of chromosome 12
                                                                                               (12p)




14q                                       C13538                        C13538 (14q )          C13538        Distal (long) arm of chromosome 14
                                                                                               (14q )




6q                                        C13560                        C13560 (6q)            C13560        Distal (long) arm of chromosome 6
                                                                                               (6q)




7-Aminoactinomycin D                      C72904   Added to EVS on 13   C72904 (7-             C72904 (7- A fluorescent nucleic acid dye which selectively        2006              152
                                                   March 2013           Aminoactinomycin D)    Aminoactin binds GC sequences in double-stranded DNA.
                                                                                               omycin D) It has a molecular weight of 1270.5, an
                                                                                                          absorbance maximun at 546 nm, and emission
                                                                                                          maximum at 647 nm. It is commonly used to
9p                                        C13563                        C13563 (9p )           C13563     discriminate viable from non-viable cells.
                                                                                                          Proximal (short) arm of chromosome 9
                                                                                               (9p )




Abnormality                               C9440                         C9440 (Abnormality )   C9440       A condition that differs from the usual physical
                                                                                               (Abnormalit or mental state.
                                                                                               y)



abortion                                  C35221                        C35221 (abortion)      C35221
                                                                                               (abortion)




                                                                                               C75520
                                                                                               (Absorbable
                                                                                               )

Absorbable                                C75520                        C75520(Absorbable)                   Capable of being taken up or taken in.
ACA positive                                                            C13198 (Centromere     (ACA
                                                                        ), C16295 (antibody)   positive)




Accident                                  C34340                        C34340 Accident        C34340        NCI|An unforeseen and unplanned event or             2900
                                                                                               (Accident)    circumstance frequently causing loss or injury.




Acquired Pure Red Cell                    C70548                        C70548 (Acquired Pure C70548
Aplasia                                                                 Red Cell Aplasia)     (Acquired
                                                                                              Pure Red
                                                                                              Cell
                                                                                              Aplasia)
acute leukemia                            C9300                         C9300 (acute           C9300
                                                                        leukemia)              (acute
                                                                                               leukemia)



acute leukemia of ambiguous               C7464                         C7464 (acute leukemia C7464
lineage                                                                 of ambiguous lineage) (acute
                                                                                              leukemia of
                                                                                              ambiguous
                                                                                              lineage)
Acute Lymphoblastic                       C3167                         C3167 (Acute           C3167
Leukemia                                                                Lymphoblastic          (Acute
                                                                        Leukemia)              Lymphoblas
                                                                                               tic
                                                                                               Leukemia)
Acute Myeloid Leukemia        AML, ANLL   C3171                         C3171 (Acute Myeloid C3171
                                                                        Leukemia)            (Acute
                                                                                             Myeloid
                                                                                             Leukemia)
Concept                      Synonym    CUI      Note   Concantenation          Concanten Definition                                                Form      Question
                                                        Values Only             ation                                                                         Number
                                                                                Formula


Acute_Graft_Versus_Host_Di              C4980                                C4980              NCI|A syndrome of immologically mediated               2900
sease                                                                        (Acute_Graf        tissue damage occurring following allogeneic
                                                        C4980                t_Versus_H         transplant usually affecting the skin, liver, and
                                                        Acute_Graft_Versus_H ost_Diseas         gi tract. Onset is usually within one hundred
                                                        ost_Disease          e)                 days of transplantation or immunologic
Add                                     C64911          C64911 (Add )        C64911             manipulation. with others so as to increase
                                                                                                To join or unite
                                                                             (Add )             size, quantity, or scope.




add(14q)                                                C64911 (Add ),           (add(14q)) To join or unite with others so as to increase             2011               33
                                                        C13538 (14q )                       size, quantity, or scope._Distal (long) arm of
                                                                                            chromosome 14



Adenosine_Deaminase_Defic               C3962           C3962               C3962
iency                                                   (Adenosine_Deaminas (Adenosine
                                                        e_Deficiency)       _Deaminas
                                                                            e_Deficienc
                                                                            y)
adenovirus                              C14179          C14179 adenovirus       C14179      NCI|A group of DNA containing viruses which                2100              430
                                                                                (adenovirus infect mammals and are capable of causing
                                                                                )           respiratory disease, including one form of the
                                                                                            common cold.

Adjuvant Therapy                        C15675          C15675 (Adjuvant        C15675
                                                        Therapy)                (Adjuvant
                                                                                Therapy)



Administered                            C25382          C25382 (Administered C25382      The act of having given something (e.g., a
                                                        )                    (Administer medication or test).
                                                                             ed )



Administration                          C25409          C25409                  C25409       The act of the dispensing, applying, or
                                                        (Administration)        (Administrat tendering of something to another, such as
                                                                                ion)         administration of a medicine.



Adverse Event                           C41331          C41331 (Adverse         C41331          Any unfavorable or unintended symptom, sign,
                                                        Event )                 (Adverse        or disease including an abnormal laboratory
                                                                                Event )         finding) temporally associated with the use of a
                                                                                                medical treatment or procedure that may or
                                                                                                may not be considered related to the medical
age                                     C25150          C25150 (age)            C25150          treatment or procedure. Such events can be
                                                                                (age)




Albumin                                 C214            C214 (Albumin)          C214            A family of globular proteins found in many
                                                                                (Albumin)       plant and animal tissues that tend to bind a
                                                                                                wide variety of ligands. Albumin is the main
                                                                                                protein in blood plasma. Low serum levels
                                                                                                occur in conditions associated with
Albumin Measurement                     C64431          C64431 (Albumin         C64431          malnutrition, inflammation and liver and kidney
                                                                                                A quantitative measurement of albumin
                                                        Measurement )           (Albumin  present in a sample
                                                                                Measureme
                                                                                nt )

Alemtuzumab                  Campath 1-H C1681                                 C1681       A recombinant DNA-derived humanized                         2006               89
                                                                               (Alemtuzum monoclonal antibody directed against the cell
                                                                               ab)         surface glycoprotein, CD52. Alemtuzumab is
                                                                                           an IgG1 kappa with human variable framework
                                                                                           and constant regions, and complementarity-
Alkylating Agent                        C223            C223 (Alkylating Agent C223        determining replace hydrogen atom(s) in
                                                                                           Agents that regions derived from a rat
                                                        )                      (Alkylating biologically active molecules with alky
                                                                               Agent )     radical(s), hindering proper function. Alkylating
                                                                                           agents exhibit cytotoxic effects through the
                                                                                           alkylation of DNA, resulting in strand cross-
Allele                                  C16277          C16277 (Allele)        C16277      linking, ultimately inhibiting DNA replication
                                                                                           Mutually exclusive alternative forms of the
                                                                                (Allele)        same gene occupying the same locus on
                                                                                                homologous chromosomes, differing in DNA
                                                                                                sequence and governing the same
                                                                                                biochemical and developmental process.
Allelotyping                            C19822          C19822 (Allelotyping)   C19822
                                                                                (Allelotyping
                                                                                )
Concept                        Synonym      CUI      Note                        Concantenation            Concanten Definition                                                Form      Question
                                                                                 Values Only               ation                                                                         Number
                                                                                                           Formula


Allogenic                      Allogeneic   C28343                               C28343 (Allogenic )       C28343       Taken from different individuals of the same
                                                                                                           (Allogenic ) species. Also called allogeneic.




Alteration                                  C28344                               C28344 (Alteration )      C28344        A change resulting in something that is
                                                                                                           (Alteration ) different from the original.




Alternative Hematopoietic                   C70632                               C70632 (Alternative       C70632
Cell Transplantation                                                             Hematopoietic Cell        (Alternative
                                                                                 Transplantation)          Hematopoie
                                                                                                           tic Cell
                                                                                                           Transplanta
AML                                         C3171                                C3171 (AML)               tion)
                                                                                                           C3171
                                                                                                           (AML)




Analysis                                    C25391                               C25391 (Analysis)         C25391         Examination and interpretation; the process of
                                                                                                           (Analysis)     identifying an issue to be understood and
                                                                                                                          addressed, modelling the issue, investigating
                                                                                                                          the model results, interpreting the results, and
                                                                                                                          possibly making a recommendation. The
Anatomic Site                               C13717                               C13717 (Anatomic          C13717         Named locations of to the examination and
                                                                                                                          concept also refers or within the body
                                                                                 Site )                    (Anatomic
                                                                                                           Site )



And/Or                                      C48928                               C48928 (And/Or)           C48928         Used to indicate that either or both of two items
                                                                                                           (And/Or)       or options may be valid.




anemia                                      C2869                                C2869 (anemia)            C2869
                                                                                                           (anemia)




Anthracycline Antineoplastic                C1594    C1594 (Anthracycline                        C1594                    Antineoplastic antibiotics isolated from the
Antibiotic                                           Antineoplastic Antibiotic                   (Anthracycli             bacterium Streptococcus peucetius var.
                                                     )                                           ne                       caesius or derived synthetically. Anthracycline
                                                                                                 Antineoplas              antibiotics exhibit potent cytotoxic properties
                                                                                                 tic Antibiotic           due to their ability to intercalate into DNA and
anti CD2 antibody                                    03-24-08: Working with C15174 (CD2 Antigen )                         An antigen that functions as II, co-receptor or
                                                                                                                          interact with topoisomerase a thereby                   2006              74
                                                     review committee to    ): C16295 (antibody)                          accessory molecule in the T-cell receptor
                                                     determine appropriate                                                complex, which is involved in helper and
                                                     concept                                                              cytotoxic T-lymphocyte adhesion and
                                                                                                                          activation. The molecule is expressed on the
anti CD3 antibody                                    03-24-08: Working with C38897 (CD3                                   cell surface of the majority of peripheral T-
                                                                                                                          Consisting of cell surface type I membrane              2006              75
                                                     review committee to    Complex): C16295                              Delta, Epsilon, Gamma, Zeta, and Eta protein
                                                     determine appropriate (antibody)                                     subunits with ITAM domains and noncovalently
                                                     concept                                                              associated with the disulfide bound
                                                                                                                          heterodimeric alpha/beta and gamma/delta
anti CD34 antibody                                   Use alternate definiition C17280 (CD34                               TCR, the CD3 complex couples receptor
                                                                                                                          Alternate Definition (MSH2001): Glycoproteins
                                                     for CD34 antigen          Antigen ): C16295                          found on immature hematopoietic cells and
                                                                               (antibody)                                 endothelial cells. They are the only molecules
                                                                                                                          to date whose expression within the blood
                                                                                                                          system is restricted to a small number of
anti CD4 antibody                                                                C16300 (CD4 Antigen                      progenitor cells in the bone marrow._A type of
                                                                                                                          CD4 Antigen, encoded by the CD4 gene, is a T-           2006              76
                                                                                 )+E506                                   cell surface glycoprotein. CD4 has a role in cell-
                                                                                                                          cell interactions and may act in signal
                                                                                                                          transduction. CD4 is a accessory protein for
                                                                                                                          MHC class-II antigen/T-cell receptor interaction
anti CD5 antibody                                                                C73124 (T-Cell                           and functions to initiate or augment the early
                                                                                                                          T-cell surface glycoprotein CD5 (495 aa, ~54            2006              77
                                                                                 Surface Glycoprotein                     kDa) is encoded by the human CD5 gene. This
                                                                                 CD5 ): C16295                            protein may be involved in regulating the
                                                                                 (antibody)                               proliferation of T-cells._A type of protein made
                                                                                                                          by B lymphocytes in response to a foreign
anti CD6 antibody                                                                C73129 (T-Cell                           substance (antigen). Each antibody only binds
                                                                                                                          T-cell differentiation antigen CD6 (668 aa, ~72         2006              78
                                                                                 Differentiation Antigen                  kDa) is encoded by the human CD6 gene. This
                                                                                 CD6 )                                    protein plays a role in the adherence of
                                                                                                                          immature thymus cells to thymic epithelial
                                                                                                                          cells._A type of protein made by B
anti CD7 antibody                                                                C38935 (T-Cell Antigen                   lymphocytes thymocytes and mature
                                                                                                                          Expressed inin response to a foreign T cells by         2006              79
                                                                                 CD7 ): C16295                            human CD7 Gene (Immunoglobulin
                                                                                 (antibody)                               Superfamily), 240-aa 25-kDa (precursor) T-
                                                                                                                          Cell Antigen CD7 is a cell surface type I
                                                                                                                          transmembrane glycoprotein that interacts with
                                                                                                                          SECTM1, contains an Ig-like domain, and is
Concept                        Synonym   CUI      Note                 Concantenation           Concanten Definition                                                Form      Question
                                                                       Values Only              ation                                                                         Number
                                                                                                Formula


anti CD8 antibody                                 03-24-08: Request                                                                                                    2006               80
                                                  pending in EVS




Anti MPO                                                               C16553 (ELISA ),         (Anti MPO)                                                             2400              452
                                                                       C71145
                                                                       (Myeloperoxidase ),
                                                                       C16295 (antibody)

Anti Pr3                                                               C16553 (ELISA ),       (Anti Pr3)                                                               2400              451
                                                                       C17548 (Proteinase-3),
                                                                       C16295 (antibody)



antibody                                 C16295                        C16295 (antibody)        C16295          A type of protein made by B lymphocytes in
                                                                                                (antibody)      response to a foreign substance (antigen).
                                                                                                                Each antibody only binds to a specific antigen,
                                                                                                                helping to destroy the antigen directly or by
                                                                                                                assisting white blood cells to destroy the
Antibody Coated Plate                    C72896   Added to EVS on 13   C72896 (Antibody         C72896          antigen. medium with a coating of monoclonal
                                                                                                                 A plastic                                             2006               62
                                                  March 2009           Coated Plate )           (Antibody       or polyclonal antibodies, often used to select or
                                                                                                Coated          deplete a population of cells which are passed
                                                                                                Plate )         over the medium.

Anticardiolipin IgG Antibody             C70990                        C70990                   C70990        An IgG autoantibody directed against
                                                                       (Anticardiolipin IgG     (Anticardioli cardiolipin. It is associated with blood clotting
                                                                       Antibody )               pin IgG       complications.
                                                                                                Antibody )

Anticardiolipin IgM Antibody             C70619                        C70619 (Anticardiolipin C70619
                                                                       IgM Antibody)           (Anticardioli
                                                                                               pin IgM
                                                                                               Antibody)

                                                                                                C75525
                                                                                                (Anti-CD25
                                                                                                Monoclonal Any monoclonal antibody directed against the
Anti-CD25 Monoclonal                                                                            Antibody)  alpha subunit of the human interleukin 2
Antibody                                 C75525                        C75525(Disturbance)                 receptor.
Anti-CD52 Monoclonal                     C72960   Added to EVS on 13   C72960 (Anti-CD52        C72960     Any monoclonal antibody directed against the                2006               86
Antibody                                          March 2015           Monoclonal Antibody )    (Anti-CD52 cell surface glycoprotein CD52, regardless of
                                                                                                Monoclonal the antibody type (e.g., rat, mouse,
                                                                                                Antibody ) humanized).

Antigen                                  C268                          C268 (Antigen)           C268            Any substance, generally a protein, that
                                                                                                (Antigen)       stimulates the immune system and elicits an
                                                                                                                immune response. Recognition by the immune
                                                                                                                system elicits either a T-lymphocyte response,
                                                                                                                recognizing processed antigens, or a B-
Antileukemic Agent                       C75574                        C75574(Antileukemic      C75574          lymphocyte response, producing antibodies
                                                                                                                Any substance that treats, prevents, or inhibits
                                                                       Agent)                   (Antileukem the development of leukemia.
                                                                                                ic Agent)



Antinuclear Antibody                     C70547                        C70547 (Antinuclear      C70547
                                                                       Antibody)                (Antinuclear
                                                                                                Antibody)



Antiphospholipid_Syndrome                C61283                        C61283                 C61283
                                                                       (Antiphospholipid_Synd (Antiphosph
                                                                       rome )                 olipid_Synd
                                                                                              rome )

Aplastic Anemia due to                   C61231                        C61231 (Aplastic         C61231
Hepatitis                                                              Anemia due to            (Aplastic
                                                                       Hepatitis)               Anemia due
                                                                                                to Hepatitis)

Aplastic Anemia due to                   C61231                        C61231 (Aplastic         C61231
Hepatitis                                                              Anemia due to            (Aplastic
                                                                       Hepatitis)               Anemia due
                                                                                                to Hepatitis)

Arrhythmia                               C2881                         C2881 (Arrhythmia)       C2881
                                                                                                (Arrhythmia
                                                                                                )
Concept                         Synonym   CUI      Note   Concantenation            Concanten Definition                                              Form      Question
                                                          Values Only               ation                                                                       Number
                                                                                    Formula


Arrival                         Arrived   C53463          C53463 (Arrival)          C53463         The act of reaching a destination.
                                                                                    (Arrival)




arthritis                                 C2883           C2883 (arthritis)         C2883
                                                                                    (arthritis)




Assessment                                C25217          C25217 (Assessment ) C25217    The act of judging the value, significance, or
                                                                               (Assessme extent of something.
                                                                               nt )



Assignment                                C25426          C25426 (Assignment ) C25426     An allotting or an appointment to a particular
                                                                               (Assignmen person or use, or for a particular time or object.
                                                                               t)



At                                        C25427          C25427 (At)               C25427         Used to indicate position, location, or state.
                                                                                    (At)




Atypical_Burkitt_s_Burkitt_s-             C6917           C6917                     C6917
Like_Lymphoma                                             (Atypical_Burkitt_s_Bur   (Atypical_B
                                                          kitt_s-Like_Lymphoma      urkitt_s_Bur
                                                          )                         kitt_s-
                                                                                    Like_Lymph
Autoimmune Disease                        C2889           C2889 (Autoimmune         oma )
                                                                                    C2889        A disorder resulting from loss of function or
                                                          Disease)                  (Autoimmun tissue destruction of an organ or multiple
                                                                                    e Disease) organs, arising from humoral or cellular
                                                                                                 immune responses of the individual to his own
                                                                                                 tissue constituents. It may be systemic (e.g.,
autologous                                C28000          C28000 (autologous)       C28000       systemic lupus erythematosus), or organ
                                                                                    (autologous
                                                                                    )



Autopsy                                   C25153          C25153 autopsy            C25153         NCI|A postmortem examination of the body              2100              426
                                                                                    (Autopsy)      that includes an examination of the internal
                                                                                                   organs and structures after dissection to
                                                                                                   determine the cause of death and the nature of
                                                                                                   pathological changes.
Bacteria                                  C14187          C14187 (Bacteria )        C14187         Unicellular, prokaryotic organisms that
                                                                                    (Bacteria )    reproduce by cell division and usually have cell
                                                                                                   walls; can be shaped like spheres, rods or
                                                                                                   spirals and can be found in virtually any
                                                                                                   environment.|
B-cell /small lymphocytic                 C7540           C7540 (B-cell /small      C7540 (B-
leukemia                                                  lymphocytic leukemia)     cell /small
                                                                                    lymphocytic
                                                                                    leukemia)

BCR-ABL_Oncoprotein                       C16325          C16325 (BCR-              C16325
                                                          ABL_Oncoprotein )         (BCR-
                                                                                    ABL_Oncop
                                                                                    rotein )

BCR-ABL1 Fusion Protein                   C36715          C36715 (BCR-ABL1          C36715
Expression                                                Fusion Protein            (BCR-ABL1
                                                          Expression)               Fusion
                                                                                    Protein
                                                                                    Expression)
Begin                           start,    C25431          C25431 (Begin)            C25431
                                                                                    (Begin)




Beta-2-Microglobulin Protein              C62657          C62657 (Beta-2-           C62657         Beta-2-microglobulin protein (119 aa, ~14 kDa)
                                                          Microglobulin Protein )   (Beta-2-       is encoded by the human B2M gene. This
                                                                                    Microglobuli   protein plays a role in immune responses and
                                                                                    n Protein )    is a key component of major histocompatibility
                                                                                                   complex class I molecules. The protein is
Biopsy                                    C15189          C15189 (Biopsy)           C15189         The removal of surface of cells and is utilized
                                                                                                   localized to the tissue specimens or fluid from
                                                                                    (Biopsy)       the living body for microscopic examination,
                                                                                                   performed to establish a diagnosis.
Concept                  Synonym   CUI      Note                 Concantenation        Concanten Definition                                                  Form      Question
                                                                 Values Only           ation                                                                           Number
                                                                                       Formula


Blast Cell                         C12918                        C12918 (Blast Cell)   C12918          Blast cells are in an immature
                                                                                       (Blast Cell)    (undifferentiated) stage in cellular
                                                                                                       development, occurring before the appearance
                                                                                                       of the definitive characteristics exhibited by
                                                                                                       fully differentiated cells.
bleomycin                          C313                          C313 (bleomycin)      C313
                                                                                       (bleomycin)




Blinded clinical study             C70840                        C70840 (blinded       C70840          NCI|A clinical study that is designed using a            2100                9
                                                                 clinical study)       (Blinded        procedure in which one or more parties to the
                                                                                       clinical        study [subject(s), investigator(s), monitor,
                                                                                       study)          or/and data analyst(s)] are kept unaware of the
                                                                                                       treatment assignment(s).
Blister                            C75564                        C75564(Blister)       C75564          An elevation of the skin filled with serous fluid.
                                                                                       (Blister)




Blood                              C12434                        C12434 (Blood)        C12434          A liquid tissue; its major function is to transport
                                                                                       (Blood)         oxygen throughout the body. It also supplies
                                                                                                       the tissues with nutrients, removes waste
                                                                                                       products, and contains various components of
                                                                                                       the immune system defending the body
Blood Transfusion                  C15192                        C15192 (Blood         C15192          against infection. Several hormones also travel
                                                                                                        The infusion of components of blood or whole
                                                                 Transfusion )         (Blood      blood into the bloodstream. The blood may be
                                                                                       Transfusion donated from another person, or it may have
                                                                                       )           been taken from the person earlier and stored
                                                                                                   until needed.
Bloom Syndrome                     C2903                         C2903 (Bloom        C2903     Bloom syndrome is an autosomal recessive
                                                                 Syndrome)           (Bloom    disorder associated with mutations in BLM
                                                                                     Syndrome) gene encoding protein that belongs to the
                                                                                               family of DNA helicases. It is characterized by
                                                                                               predisposition to cancer, immunodeficiency,
Bone Marrow                        C12431                        C12431 (Bone Marrow C12431    high sensitivity to UV tissue in the instability
                                                                                               The soft, sponge-like and genomiccenter of of
                                                                 )                   (Bone     bones that produces white blood cells, red
                                                                                     Marrow )  blood cells, and platelets.



bortezomib                         C1851                         C1851 (bortezomib)    C1851
                                                                                       (bortezomib
                                                                                       )



breast carcinoma                   C4872                         C4872 (breast         C4872
                                                                 carcinoma)            (breast
                                                                                       carcinoma)



Bronchoalveolar_Lavage             C51913                        C51913               C51913      NCI|Washing out the bronchi and alveoli by                    2100              423
                                                                 Bronchoalveolar_Lava (Bronchoalv flushing with a fluid.
                                                                 ge                   eolar_Lava
                                                                                      ge)

Buffy Coat Preparation             C72895   Added to EVS on 13   C72895 (Buffy Coat    C72895          A process using centrifugation of whole blood            2006               47
                                            March 2008           Preparation )         (Buffy Coat     to obtain a white blood cell layer highly
                                                                                       Preparation     enriched for neutrophils, lymphocytes,
                                                                                       )               monocytes and progenitor cells.

Burkitt cell leukemia              C7400                         C7400 (Burkitt cell   C7400
                                                                 leukemia)             (Burkitt cell
                                                                                       leukemia)



Burkitt's lymphoma                 C2912                         C2912 (Burkitt's      C2912
                                                                 lymphoma)             (Burkitt's
                                                                                       lymphoma)



busulfan                           C321                          C321 (busulfan)       C321
                                                                                       (busulfan)




C3                                                               C21527 (Complement     (C3)                                                                    2400              380
                                                                 Component 3 )
Concept           Synonym   CUI      Note                   Concantenation            Concanten Definition                                             Form      Question
                                                            Values Only               ation                                                                      Number
                                                                                      Formula


C4                                                          C70618 (Complement        (C4)                                                                2400              381
                                                            Component-4 )




Campath NOS                          Working with EVS                                 (Campath                                                            2006               87
                                                                                      NOS)




Campath-1G                  C72959   Added to EVS on 13     C72959 (Campath-1G C72959              A rat IgG2b monoclonal antibody directed               2006               88
                                     March 2014             )                  (Campath-           against the cell surface glycoprotein CD52. It is
                                                                               1G )                used in HCT to prevent GVHD by eliminating T
                                                                                                   cells via antibody dependent cell cytotoxicity in
                                                                                                   vivo.
c-ANCA IFA                                                  C17370 (Fluorescent    (c-ANCA                                                                2400              453
                                                            Antibody Technique ), IFA)
                                                            C17548 (Proteinase-3)
                                                            , C16295 (antibody)

c-ANCA Positive                                             C17998 (Unknown),         (c-ANCA                                                             2400              450
                                                            C25294 (laboratory        Positive)
                                                            procedure), C17548
                                                            (Proteinase-3) ,
                                                            C16295 (antibody)
Carcinoma                   C2916    This concept refers       C2916 (Carcinoma )     C2916      A malignant tumor arising from epithelial cells.
                                     specifically to malignant                        (Carcinoma Carcinomas that arise from glandular
                                     tumors that begin in                             )          epithelium are called adenocarcinomas, those
                                     epithelial cells. For                                       that arise from squamous epithelium are called
                                     generic "cancer,"                                           squamous cell carcinomas, and those that
                                     please use the concept                                      arise from transitional epithelium are called
                                     C9305 (Malignant                                            transitional cell carcinomas. Morphologically,
                                     Neoplasm ).                                                 the malignant epithelial cells may display
                                                                                                 abnormal mitotic figures, anaplasia, and
                                                                                                 necrosis. Carcinomas are graded by the
                                                                                                 degree of cellular differentiation as well,
                                                                                                 moderately, or poorly differentiated.
                                                                                                 Carcinomas invade the surrounding tissues
                                                                                                 and tend to metastasize to other anatomic
                                                                                                 sites. Lung carcinoma, skin carcinoma, breast
                                                                                                 carcinoma, colon carcinoma, and prostate
                                                                                                 carcinoma are the most frequently seen
                                                                                                 carcinomas.

Carmustine                  C349                            C349 (Carmustine)         C349        An antineoplastic nitrosourea. Carmustine               2400               61
                                                                                      (Carmustine alkylates and cross-links DNA during all
                                                                                      )           phases of the cell cycle, resulting in disruption
                                                                                                  of DNA function, cell cycle arrest, and
                                                                                                  apoptosis. This agent also carbamoylates
                                                                                                  proteins, including DNA repair


category                    C25372                          C25372 (category)         C25372
                                                                                      (category)




CD2 Antigen                 C15174                          C15174 (CD2 Antigen C15174             An antigen that functions as a co-receptor or
                                                            )                   (CD2               accessory molecule in the T-cell receptor
                                                                                Antigen )          complex, which is involved in helper and
                                                                                                   cytotoxic T-lymphocyte adhesion and
                                                                                                   activation. The molecule is expressed on the
CD20 Antigen                C38896                          C38896 (CD20              C38896       cell surfaceduring B-cell ontogeny (earlyT-
                                                                                                   Expressed of the majority of peripheral pre-B-         2111               75
                                                            Antigen)                  (CD20        cell to plasma cell) by human CD20 Gene
                                                                                      Antigen)     (MS4A Family), 297-aa 33-kDa CD20 Antigen
                                                                                                   is a phosphorylated cell surface integral
                                                                                                   membrane protein shown to participate in B-
CD20+ Cells       CD20                                      C38896 (CD20                           cell proliferation, development, and                   2111               75
                                                            Antigen):C25626
                                                            (Present):C12508 (cell)



CD3 Complex                 C38897                          C38897 (CD3               C38897       Consisting of cell surface type I membrane
                                                            Complex)                  (CD3         Delta, Epsilon, Gamma, Zeta, and Eta protein
                                                                                      Complex)     subunits with ITAM domains and noncovalently
                                                                                                   associated with the disulfide bound
                                                                                                   heterodimeric alpha/beta and gamma/delta
CD3+ cells                                                  C38897 (CD3                            TCR, the CD3 complex couples receptor
                                                                                                   Consisting of cell surface type I membrane             2006              148
                                                            Complex):C25626                        Delta, Epsilon, Gamma, Zeta, and Eta protein
                                                            (Present):C12508 (cell)                subunits with ITAM domains and noncovalently
                                                                                                   associated with the disulfide bound
                                                                                                   heterodimeric alpha/beta and gamma/delta
                                                                                                   TCR, the CD3 complex couples receptor
Concept                  Synonym     CUI      Note                        Concantenation            Concanten Definition                                              Form      Question
                                                                          Values Only               ation                                                                       Number
                                                                                                    Formula


CD34 Antigen                         C17280   Use the alternate           C17280 (CD34              C17280       Alternate Definition (MSH2001):
                                              MSH2001 definition          Antigen )                 (CD34        Glycoproteins found on immature
                                                                                                    Antigen )    hematopoietic cells and endothelial cells. They
                                                                                                                 are the only molecules to date whose
                                                                                                                 expression within the blood system is restricted
CD34 Selection                                Do not use concept          C17280 (CD34                           to a small number of progenitor cells in the
                                              C70621. At some point       Antigen ), C71257
                                              that concept will be        (Positive Selection )
                                              retired. Be sure to use
                                              alternate definition for
CD34+ cells                                   CD34 Antigen.
                                              Use alternate definiition   C17280 (CD34                           Alternate Definition (MSH2001): Glycoproteins           2006              147
                                              for CD34 antigen            Antigen ):C25626                       found on immature hematopoietic cells and
                                                                          (Present):C12508 (cell)                endothelial cells. They are the only molecules
                                                                                                                 to date whose expression within the blood
                                                                                                                 system is restricted to a small number of
CD4 Antigen                          C16300                               C16300 (CD4 Antigen C16300             progenitor cells in the bone marrow._Being or T-
                                                                                                                 CD4 Antigen, encoded by the CD4 gene, is a
                                                                          )                   (CD4               cell surface glycoprotein. CD4 has a role in cell-
                                                                                              Antigen )          cell interactions and may act in signal
                                                                                                                 transduction. CD4 is a accessory protein for
                                                                                                                 MHC class-II antigen/T-cell receptor interaction
CD4+ cells                                                                C16300 (CD4 Antigen (CD4+              CD4functions encoded by augment gene, is a T-
                                                                                                                 and Antigen, to initiate or the CD4 the early           2006              149
                                                                          ):C25626                cells)         cell surface glycoprotein. CD4 has a role in cell-
                                                                          (Present):C12508 (cell)                cell interactions and may act in signal
                                                                                                                 transduction. CD4 is a accessory protein for
                                                                                                                 MHC class-II antigen/T-cell receptor interaction
CD40 Ligand Deficiency               C61244                               C61244 (CD40 Ligand C61244             and functions to initiate or augment the early
                                                                          Deficiency)         (CD40
                                                                                              Ligand
                                                                                              Deficiency)

CD56+ Cells              CD56                                             C25276                  (CD56+
                                                                           (Neural Cell Adhesion Cells)
                                                                          Molecule):C25626
                                                                          (Present):C12508 (cell)

CD8+ cells                                    03-24-08: Request                                      (CD8+                                                               2006              150
                                              pending in EVS                                        cells)




CDW52 Antigen                        C38908   Be sure to use the    C38908 ( CDW52                  C38908       Encoded by the CDW52 wt Allele, CDW52 is a              2006               88
                                              definition specified  Antigen )                       (CDW52       glycosylphosphatidylinositol-anchored
                                              here. As of 13 March                                  Antigen )    glycoprotein expressed on the surface of
                                              2008, this was the                                                 essentially all normal and malignant B and T
                                              caDSR definition and                                               cells, a majority of monocytes, macrophages
cell                                 C12508   not the NCI Thesaurus C12508 (cell)                   C12508       and smallest units of living structure capable of
                                                                                                                 The natural killer (NK) cells, a subpopulation of
                                                                                                    (cell)       independent existence, composed of a
                                                                                                                 membrane-enclosed mass of protoplasm and
                                                                                                                 containing a nucleus or nucleoid.

Cell Sorting             Cell        C16406                               C16406 (Cell Sorting)     C16406       Techniques and methods for separating cells             2006               48
                         Separator                                                                  (Cell        (usually viable) based on a variety of criteria
                                                                                                    Sorting)     for separation, such as size or density, non-
                                                                                                                 specific surface properties, or specific surface
                                                                                                                 properties. Examples include cell affinity
Cell Wash                            C76322                               C76322(Cell Wash          C76322       chromatography and centrifugation using
                                                                                                                 The process of applying a solvent (e.g., water)
synonym: Wash                                                             synonym: Wash)            (Cell Wash or a solution (e.g., SSC/SDS) to a biomaterial
                                                                                                    synonym:   or an array to remove impurities or unwanted
                                                                                                    Wash)      compounds.

Cellular Therapy                     C70601                               C70601 (Cellular          C70601
                                                                          Therapy)                  (Cellular
                                                                                                    Therapy)



Central Nervous System               C5440                                C5440 (Central            C5440
Leukemia                                                                  Nervous System            (Central
                                                                          Leukemia )                Nervous
                                                                                                    System
                                                                                                    Leukemia )
Central_Nervous_System   CNS         C12438                               C12438                C12438      The part of the nervous system that consists of
                                                                          (Central_Nervous_Syst (Central_Ne the brain, spinal cord, and meninges.
                                                                          em)                   rvous_Syst
                                                                                                em)

Centromere                           C13198                               C13198 (Centromere ) C13198     The nonstaining primary constriction of a
                                                                                               (Centromer chromosome which is the point of attachment
                                                                                               e)         of the spindle fiber; provides the mechanism of
                                                                                                          chromosome movement during cell division;
                                                                                                          the centromere divides the chromosome into
                                                                                                          two arms, and its position is constant for a
Concept                      Synonym   CUI      Note   Concantenation           Concanten Definition                                                 Form      Question
                                                       Values Only              ation                                                                          Number
                                                                                Formula


Cerebrovascular_Disorder               C2938           C2938                 C2938
                                                       (Cerebrovascular_Diso (Cerebrova
                                                       rder)                 scular_Diso
                                                                             rder)

Change                                 C25446          C25446 (Change)          C25446          NCI|The act of alteration or modification;
                                                                                (Change)        changed or altered in form or character.




Chemotherapy                           C15632          C15632                   C15632
                                                       (Chemotherapy)           (Chemother
                                                                                apy)



Chimerism                              C62582          C62582 chimerism         C62582      NCI|The occurrence in an individual of two or               2100
                                                                                (Chimerism) more cell populations of different chromosomal
                                                                                            constitutions, derived from different individuals.
                                                                                            This contrasts with mosaicism in which the
                                                                                            different cell populations are derived from a
Chronic Graft Versus Host              C4981                                    C4981       NCI|A individual. of immologically mediated
                                                                                            single syndrome                                             2900
Disease                                                                       (Chronic    tissue damage occurring following allogeneic
                                                                              Graft       transplant and may affect multiple organs with
                                                                              Versus Host manifestations similar to autoimmune
                                                                                          diseases. Onset is usually within three years of
                                                                              Disease) Disease
                                                       C4981 Chronic Graft Versus Host
chronic myelomonocytic                 C3178           C3178 (chronic         C3178       transplantation or immunologic manipulation.
leukemia (CMML)                                        myelomonocytic           (chronic
                                                       leukemia (CMML))         myelomono
                                                                                cytic
                                                                                leukemia
Chronic Myeloproliferative   MPS       C4345           C4345 (Chronic           (CMML))
                                                                                C4345        Chronic myeloproliferative disorders (CMPDs)
Disorder                                               Myeloproliferative       (Chronic     are clonal hematopoietic stem cell disorders,
                                                       Disorder)                Myeloprolife characterized by proliferation in the bone
                                                                                rative       marrow of one or more of the myeloid (i.e.,
                                                                                Disorder)    granulocytic, erythroid, and megakaryocytic)
Chronic_Lymphocytic_Leuke              C3163           C3163                    C3163        lineages. The proliferation is associated with
mia                                                    (Chronic_Lymphocytic_ (Chronic_Ly
                                                       Leukemia)             mphocytic_
                                                                             Leukemia)

Churg-Strauss_Syndrome                 C34481          C34481 (Churg-           C34481          Widespread necrotizing angiitis with
                                                       Strauss_Syndrome )       (Churg-         granulomas. Pulmonary involvement is
                                                                                Strauss_Sy      frequent. Asthma or other respiratory infection
                                                                                ndrome )        may precede evidence of vasculitis.
                                                                                                Eosinophilia and lung involvement differentiate
classification                         C25161          C25161 (classification) C25161           this disease from POLYARTERITIS NODOSA
                                                                               (classificatio
                                                                               n)



Clerk                                  C75552          C75552(Clerk             C75552          A person employed in an office who performs
syn: Clerical Occupation                               syn: Clerical            (Clerk          various tasks such as keeping records or
syn: Clerical Work                                     Occupation               syn: Clerical   accounts, filing, letter writing, or transcribing.
                                                       syn: Clerical Work)      Occupation
                                                                                syn: Clerical
Clinical                               C25398          C25398 (Clinical )       Work)
                                                                                C25398          Relating to the examination and treatment of
                                                                                (Clinical )     patients dependent on direct observation. The
                                                                                                term may also refer to the institution (clinic)
                                                                                                providing this activity.

Clinical Study                         C15206          C15206 (Clinical Study C15206            Research conducted with human subjects or
                                                       )                      (Clinical         on material of human origin in which an
                                                                              Study )           investigator directly interacts with human
                                                                                                subjects; includes development of new
                                                                                                technologies, mechanism of human diseases,
CML                                    C3174           C3174 (CML)              C3174           therapy, clinical trials, epidemiology, behavior
                                                                                (CML)




collection                             C25453          C25453 (collection)      C25453
                                                                                (collection)




Colony Forming Unit          CFU       C68742          C68742 (Colony           C68742          A unit of measurement of viable bacterial
                                                       Forming Unit )           (Colony         numbers. Colony forming unit (CFU) is the
                                                                                Forming         minimum number of separable cells, which is
                                                                                Unit )          able to produce a visible colony of progeny.
                                                                                                The examples of CFU usage include but not
                                                                                                limited to the measurement of the number of
Concept                       Synonym        CUI      Note   Concantenation         Concanten Definition                                                Form      Question
                                                             Values Only            ation                                                                         Number
                                                                                    Formula


Colony-Forming Unit-          CFU-GM         C63799          C63799 (Colony-        C63799      A functional (qualitative) as well as quantitative
Granulocyte Macrophage        Assay                          Forming Unit-          (Colony-    assay that is utilized as an indicator of
Assay                                                        Granulocyte            Forming     granulopoiesis reconstitution.
                                                             Macrophage Assay)      Unit-
                                                                                    Granulocyte
combination chemotherapy                     C191            C191 (combination      Macrophag
                                                                                    C191
                                                             chemotherapy)          (combinatio
                                                                                    n
                                                                                    chemothera
                                                                                    py)
comorbidity                                  C16457          C16457 (comorbidity)   C16457
                                                                                    (comorbidity
                                                                                    )



Complement                                   C16459          C16459 (Complement) C16459    The complement system is a complex system
                                                                                 (Compleme of serum proteins that interact in a cascade.
                                                                                 nt)       Many of the early components are serine
                                                                                           proteases that activate each other
                                                                                           sequentially. This complement system consists
Complement Component-4                       C70618          C70618 (Complement C70618     Complement component-4 (1744 aa,(1) Ab
                                                                                           of three separate activation triggers: ~193
                                                             Component-4 )          (Compleme      kDa) is part of the complement cascade, which
                                                                                    nt             mediates the innate immune response to
                                                                                    Component-     infection. The full length protein is a precursor
                                                                                    4)             that can is secreted as a trimeric molecule
Complement Hemolytic                         C70611          C70611 (Complement C70611             containing an alpha, beta and gamma chain.
                                                                                                   A screening assay for circulating complement
Activity Assay                                               Hemolytic Activity (Compleme          proteins in which diluted serum samples are
                                                             Assay )            nt Hemolytic       added to antibody-coated erythrocytes and the
                                                                                Activity           percentage of cell lysis is measured. The
                                                                                Assay )            values are expressed in hemolytic complement
complete remission                           c4870           c4870 (complete        c4870          units per milliliter (CH50), the dilution of serum
                                                             remission)             (complete
                                                                                    remission)



Complete Response of                         C70639          C70639 (Complete     C70639
Multiple Myeloma or Plasma                                   Response of Multiple (Complete
Cell Leukemia                                                Myeloma or Plasma    Response
                                                             Cell Leukemia)       of Multiple
                                                                                  Myeloma or
Complete_Remission            complete       C4870           C4870                Plasma Cell The disappearance of all signs of cancer in
                                                                                  C4870
                              response                       (Complete_Remission) (Complete_ response to treatment. This does not always
                                                                                  Remission) mean the cancer has been cured.



Concurrent                                   C25456          C25456 (Concurrent )   C25456
                                                                                    (Concurrent
                                                                                    )



confirmed                     confirmation   C25458          C25458 (confirmed)     C25458                                                                 2900
                                                                                    (confirmed )


                                                                                                   NCI|Having been established or verified.
Congenital Abnormality                       C2849           C2849 (Congenital      C2849
                                                             Abnormality)           (Congenital
                                                                                    Abnormality
                                                                                    )

Congenital_Platelets_Abnorm                  C61247          C61247                 C61247
ality                                                        (Congenital_Platelets_ (Congenital
                                                             Abnormality)           _Platelets_
                                                                                    Abnormality
                                                                                    )
Connective_Tissue_Disorder Connective        C26729          C26729                C26729          A heterogeneous group of disorders, some
                           Tissue                            (Connective_Tissue_Di (Connective     hereditary, others acquired, characterized by
                           Disease                           sorder )              _Tissue_Di      abnormal structure or function of one or more
                                                                                   sorder )        of the elements of connective tissue, i.e.,
                                                                                                   collagen, elastin, or the mucopolysaccharides.
Consolidation Therapy                        C15679          C15679 (Consolidation C15679       Chemotherapy treatments given after induction
                                                             Therapy )             (Consolidati chemotherapy to further reduce the number of
                                                                                   on Therapy cancer cells.
                                                                                   )

Continued Complete                           C70603          C70603 (Continued      C70603
Response                                                     Complete Response)     (Continued
                                                                                    Complete
                                                                                    Response)
Concept                     Synonym     CUI        Note                    Concantenation        Concanten Definition                                              Form      Question
                                                                           Values Only           ation                                                                       Number
                                                                                                 Formula


Conventional Cytogenetics   Chromosome C16437      Use this concept for    C16437 (Chromosome C16437           The treatment of chromosomes to reveal
                            Banding                conventional            Banding)           (Chromoso        characteristic patterns of horizontal bands.
                                                   cytogenetics per Doug                      me               The banding patterns lend each chromosome
                                                   Rizzo 8/26/08sc.                           Banding)         a distinctive appearance so the 22 pairs of
                                                                                                               human non-sex chromosomes and the X and
CPK                                                                        C64489 (Creatine      (CPK)         Y chromosomes can be identified and                    2400              413
                                                                           Kinase Measurement)




Creatine Kinase                         C64489                             C64489 (Creatine      C64489
Measurement                                                                Kinase Measurement)   (Creatine
                                                                                                 Kinase
                                                                                                 Measureme
                                                                                                 nt)
CREST Syndrome                          C70646                             C70646 (CREST         C70646
                                                                           Syndrome)             (CREST
                                                                                                 Syndrome)



Crohn's Disease                         C2965                              C2965 (Crohn's        C2965
                                                                           Disease)              (Crohn's
                                                                                                 Disease)



Cryopreservation            Cryopreserve C16475                            C16475                C16475      Preservation of cells, tissues, organs, or
                            d                                              (Cryopreservation )   (Cryopreser embryos by storage at low temperatures.
                                                                                                 vation )



Culture Procedure                       C25300                             C25300 (Culture       C25300      Any laboratory procedure for growing
                                                                           Procedure )           (Culture    microorganisms.
                                                                                                 Procedure )



current                                 C25471                             C25471 (current)      C25471
                                                                                                 (current)




cutaneous                               C13316                             C13316 (cutaneous)    C13316
                                                                                                 (cutaneous)




cutaneous invlovement                   C39570                             C39570 (cutaneous     C39570
                                                                           invlovement)          (cutaneous
                                                                                                 invlovement
                                                                                                 )

Cycle                                   C25472                             C25472 (Cycle )       C25472        An event or sequence of events that constitute
                                                                                                 (Cycle )      a round or succession of observable
                                                                                                               phenomena, recurring usually at regular or
                                                                                                               approximately regular time intervals and in the
                                                                                                               same sequence.
Cystitis                                C26738                             C26738 (cystitis)     C26738        MSH2003_2003_05_12|Inflammation of the                 2900
                                                                                                 (Cystitis)    urinary bladder. (Dorland, 27th ed)




Cytarabine                  Ara-C       C408       Per Doug's request      C408 (Cytarabine )    C408        An antimetabolite analogue of cytidine with a            2400               69
                                                   please be sure to use                         (Cytarabine modified sugar moiety (arabinose instead of
                                                   the NCI Thesaurus                             )           ribose). Cytarabine is converted to the
                                                   definition                                                triphosphate form within the cell and then
                                                                                                             competes with cytidine for incorporation into
Cytogenetic Analysis        Cytogenetics, C18280   Use this concept for    C18280 (Cytogenetic   C18280      DNA. Because the arabinose sugar sterically
                                                                                                             Techniques for analysis of chromosomal and
                            Cytogenetic            cytogenetic analysis    Analysis )            (Cytogeneti subchromosomal properties and structures,
                            Technique              per Doug Rizzo                                c Analysis ) such as those to diagnose, classify, screen for,
                                                   8/26/08sc.                                                 or manage genetic diseases and
                                                                                                              abnormalities.
Cytogenetic Remission                                                      C18280 (Cytogenetic
                                                                           Analysis ), C18246    (Cytogeneti
                                                                           (remission)           c
                                                                                                 Remission)

cytokine                                C20464                             C20464 (cytokine)     C20464        NCI|A class of soluble glycoproteins which act         2100                9
                                                                                                 (cytokine)    nonenzymatically through specific receptors to
                                                                                                               regulate immune responses. Cytokines are
                                                                                                               derived from both immune and non-immune
                                                                                                               cells and are intercellular mediators that differ
                                                                                                               from hormones in that they are produced by a
Concept                    Synonym      CUI      Note                   Concantenation          Concanten Definition                                               Form      Question
                                                                        Values Only             ation                                                                        Number
                                                                                                Formula


cytomegalovirus            CMV          C14196                          C14196                C14196      NCI|A genus of the family herpesviridae,                    2100              431
                                                                        cytomegalovirus (CMV) (cytomegalo subfamily betaherpesvirinae, infecting the
                                                                                              virus)      salivary glands, liver, spleen, lungs, eyes, and
                                                                                                          other organs, in which they produce
                                                                                                          characteristically enlarged cells with
cytopenia                               C2979                           C2979 (cytopenia)     C2979       intranuclear in the number of blood cells.
                                                                                                          A reduction inclusions.
                                                                                                (cytopenia)




Daclizumab                 Anti CD25    C1569    Use NCI-GLOSS          C1569 (Daclizumab )     C1569      A monoclonal antibody that is being studied for
                           Zenepax               definition                                     (Daclizuma treatment of adult T-cell leukemia. Also called
                           Daclizumab                                                           b)         dacliximab. Monoclonal antibodies are
                           AntiTAC                                                                         laboratory-produced substances that can
                                                                                                           locate and bind to cancer cells.
Dasatinib                               C38713                          C38713 (Dasatinib)      C38713
                                                                                                (Dasatinib)




daunorubicin                            C62091                          C62091 (daunorubicin) C62091      An anthracycline antineoplastic antibiotic with
                                                                                              (daunorubic therapeutic effects similar to those of
                                                                                              in)         doxorubicin. Daunorubicin exhibits cytotoxic
                                                                                                          activity through topoisomerase-mediated
                                                                                                          interaction with DNA, thereby inhibiting DNA
Day                                     C25301                          C25301 (Day )         C25301      replication and repair and RNA and protein
                                                                                                          The time for Earth to make a complete rotation
                                                                                                (Day )         on its axis; ordinarily divided into twenty-four
                                                                                                               hours, equal to 86 400 seconds. This also
                                                                                                               refers to a specific day.

Death                                   C28554                          C28554 (Death )         C28554         The absence of life or state of being dead.
                                                                                                (Death )




Death Related to Adverse                C48275                          C48275 (Death           C48275         The termination of life associated with an
Event                                                                   Related to Adverse      (Death         adverse event.
                                                                        Event )                 Related to
                                                                                                Adverse
                                                                                                Event )
del(12p)/12p-                                                           C45577 (Deletion                      Loss of a genomic DNA sequence. The extent              2011               32
                                                                        Abnormality ), C13532   (del(12p)/12 of a deletion ranges from the loss of a single
                                                                        (12p)                   p-)           nucleotide to the loss of a substantial portion of
                                                                                                              an entire chromosome. Thus, deletions may
                                                                                                              alter the function of a single gene or multiple
del(6q)/6q-                                                             C45577 (Deletion                      genes._Proximal (short) arm of chromosome
                                                                                                 (del(6q)/6q- Loss of a genomic DNA sequence. The extent              2011               30
                                                                        Abnormality ), C13560   )             of a deletion ranges from the loss of a single
                                                                        (6q)                                  nucleotide to the loss of a substantial portion of
                                                                                                              an entire chromosome. Thus, deletions may
                                                                                                              alter the function of a single gene or multiple
del(9p)/9p-                                                             C45577 (Deletion                      genes._Distal (long) arm of chromosome 6
                                                                                                 (del(9p)/9p- Loss of a genomic DNA sequence. The extent              2011               31
                                                                        Abnormality ), C13563   )             of a deletion ranges from the loss of a single
                                                                        (9p )                                 nucleotide to the loss of a substantial portion of
                                                                                                              an entire chromosome. Thus, deletions may
                                                                                                              alter the function of a single gene or multiple
Deletion Abnormality                    C45577   Do not use concept     C45577 (Deletion        C45577        Loss of a genomic DNA arm of chromosome
                                                                                                              genes. _Proximal (short)sequence. The extent
                                                 C19296 (Deletion       Abnormality )       (Deletion   of a deletion ranges from the loss of a single
                                                 Mutation) per Doug's                       Abnormality nucleotide to the loss of a substantial portion of
                                                 request                                    )           an entire chromosome. Thus, deletions may
                                                                                                        alter the function of a single gene or multiple
Department                              C42671                          C42671 (Department) C42671      genes.
                                                                                                        A specialized division of a large organization.
                                                                                            (Departmen
                                                                                            t)



Dermatomyositis                         C26744                          C26744                  C26744
                                                                        (Dermatomyositis)       (Dermatom
                                                                                                yositis)



Description                             C25365                          C25365 (Description)    C25365       A written or verbal account, representation,
                                                                                                (Description statement, or explanation of something.
                                                                                                )



Destructive Arthritis                   C70634                          C70634 (Destructive     C70634
                                                                        Arthritis)              (Destructive
                                                                                                Arthritis)
Concept                        Synonym      CUI      Note                 Concantenation         Concanten Definition                                               Form      Question
                                                                          Values Only            ation                                                                        Number
                                                                                                 Formula


Detection                                   C16210                        C16210 detection       C16210      NCI|The activity of perceiving, discerning,               2100              586
                                                                                                 (Detection) discovering or identifying.




Diabetes Mellitus                           C2985                         C2985 (Diabetes        C2985
                                                                          Mellitus)              (Diabetes
                                                                                                 Mellitus)



diagnosis                                   C15220                        C15220 (diagnosis)     C15220      NCI|The investigation, analysis and recognition
                                                                                                 (diagnosis) of the presence and nature of disease,
                                                                                                             condition, or injury from expressed signs and
                                                                                                             symptoms; also, the scientific determination of
                                                                                                             any kind; the concise results of such an
diagnostic procedure                        C18020                        C18020 diagnostic      C18020      investigation. procedures, and tests performed
                                                                                                             NCI|Methods,                                              2100              424
                                                                          procedure              (diagnostic    to diagnose disease, disordered function, or
                                                                                                 procedure)     disability.



Diagnostic, Therapeutic, and                C19238                        C19238 (Diagnostic,  C19238       An object needed to perform a diagnostic,
Research Equipment                                                        Therapeutic, and     (Diagnostic, therapeutic or research activity.
                                                                          Research Equipment ) Therapeutic
                                                                                               , and
                                                                                               Research
diffuse                                     C14175                        C14175 (diffuse)     Equipment ) widely spread; not localized or confined
                                                                                               C14175
                                                                                               (diffuse)




Dimethyl Sulfoxide                          C437     Be sure to use the    C437 (Dimethyl        C437           A highly polar organic liquid that is used widely      2006               41
                                                     definition specified  Sulfoxide )           (Dimethyl      as a chemical solvent and a free radical
                                                     here. As of 13 March                        Sulfoxide )    scavenger. It shows a range of
                                                     2008, this was the                                         pharmacological activity including analgesia
                                                     caDSR definition and                                       and anti-inflammation. Because of its ability to
Disease response                            C50995   not the NCI Thesaurus C50995 disease        C50995         penetrate biological membranes, it is used
                                                                                                                NCI-GLOSS|In medicine, an improvement as               2100
                                                                           response              (Disease       related to treatment.
                                                                                                 response)



diseases and disorders                      C2991                         C2991 (diseases and    C2991
                                                                          disorders)             (diseases
                                                                                                 and
                                                                                                 disorders)

                                                                                                 C75521
                                                                                                 (Disturbanc
                                                                                                 e)
                                                                                                           A departure or divergence from that which is
Disturbance                                 C75521                        C75521(Disturbance)              considered normal.
Down Syndrome                  Trisomy 21   C2993                         C2993 (Down            C2993     A chromosomal dysgenesis syndrome
                               Syndrome                                   Syndrome)              (Down     resulting from a triplication or translocation of
                                                                                                 Syndrome) chromosome 21. Down syndrome occurs in
                                                                                                           approximately 1:700 live births. Abnormalities
                                                                                                           are variable from individual to individual and
doxorubicin                                 C456                          C456 (doxorubicin)     C456      An anthracycline antibiotic with retarded
                                                                                                           may include mental retardation,antineoplastic
                                                                                                 (doxorubicin activity. Doxorubicin, isolated from
                                                                                                 )            Streptomyces peucetius var. caesius, is the
                                                                                                              hydroxylated congener of daunorubicin.
                                                                                                              Doxorubicin intercalates between base pairs in
Drug/Toxin-Induced Aplastic                 C70613                        C70613 (Drug/Toxin-    C70613       the DNA helix, thereby preventing DNA
Anemia                                                                    Induced Aplastic       (Drug/Toxin-
                                                                          Anemia)                Induced
                                                                                                 Aplastic
                                                                                                 Anemia)
Drug-Induced Aplastic                       C35343                        C35343 (Drug-Induced C35343
Anemia                                                                    Aplastic Anemia)     (Drug-
                                                                                               Induced
                                                                                               Aplastic
                                                                                               Anemia)
ds DNA                                                                    C1580 (anti-DNA        (ds DNA)                                                              2400              279
                                                                          antibody)




Electromyography                            C38056                        C38056                 C38056
                                                                          (Electromyography )    (Electromyo
                                                                                                 graphy )
Concept                      Synonym       CUI      Note                  Concantenation          Concanten Definition                                            Form      Question
                                                                          Values Only             ation                                                                     Number
                                                                                                  Formula


elevated                                   C25493                         C25493 (elevated)       C25493
                                                                                                  (elevated)




ELISA                        Enzyme-    C16553                            C16553 (ELISA )         C16553       An immunoassay utilizing an antibody labeled
                             linked                                                               (ELISA )     with an enzyme marker such as horseradish
                             Immunosorb                                                                        peroxidase. While either the enzyme or the
                             ent Assay                                                                         antibody is bound to an immunosorbent
                                                                                                               substrate, they both retain their biologic
Elutriative Centrifugation   Elutriation   C18798                                                 C18798       activity; the change in on the activity their
                                                                                                               Separation of particlesenzymebasis of as a            2006               67
                                                                                                  (Elutriative differential sedimentation rate.|
                                                                                                  Centrifugati
                                                                                                  on )

Engraftment                                C37947                         C37947 (Engraftment ) C37947
                                                                                                (Engraftme
                                                                                                nt )



Episode                                    C75539                         C75539(Episode)         C75539       A noteworthy happening that is distinctive in a
                                                                                                  (Episode)    series of related events.




Erythroblast                               C12527   Be sure to use the    C12527 (Erythroblast)   C12527       A nucleated cell in bone marrow from which
                                                    definition specified                          (Erythroblas red blood cells develop.
                                                    here. As of 18 March                          t)
                                                    2008, this was the
                                                    caDSR definition and
Erythrocyte                  Red blood     C12521   not the NCI Thesaurus C12521 (Erythrocyte )   C12521       Cell specialized for oxygen transport, having a
                             cell                                                                 (Erythrocyte high concentration of hemoglobin in the
                                                                                                  )            cytoplasm and little else; biconcave, anucleate
                                                                                                               discs, 7nm diameter in mammals.

Erythropoietin                             C477                           C477                 C477         NCI|A recombinant therapeutic agent which is             2100                9
                                                                          (Recombinant_Erythro (Erythropoie chemically identical to or similar to the
                                                                          poietin)             tin)         endogenous glycoprotein erythropoietin (Epo).
                                                                                                            Epo promotes the differentiation and
                                                                                                            maturation of hematopoietic progenitors into
esophagus                                  C12389                         C12389 (esophagus)   C12389       erythrocytes; is a mitogen and a
                                                                                                  (esophagus
                                                                                                  )



established                                C71155                         C71155 established      C71155       NCI|Shown to be valid beyond a reasonable             2100
                                                                                                  (established doubt.
                                                                                                  )



Etanercept                   Enbrel        C2381                          C2381 (Etanercept )     C2381       A recombinant soluble dimeric fusion protein           2400              151
                                                                                                  (Etanercept consisting of the extracellular ligand-binding
                                                                                                  )           region of recombinant human tumor necrosis
                                                                                                              factor (rhTNF) receptor attached to the
                                                                                                              constant (Fc) region of human immunoglobulin
Etiology                                   C16390                         C16390 (Etiology)       C16390      G (FcIgG). of a disease. moiety of etanercept
                                                                                                              The cause The receptor
                                                                                                  (Etiology)




etoposide                                  C491                           C491 (etoposide)        C491        A semisynthetic derivative of podophyllotoxin,
                                                                                                  (etoposide) a substance extracted from the mandrake root
                                                                                                              Podophyllum peltatum. Possessing potent
                                                                                                              antineoplastic properties, etoposide binds to
                                                                                                              and inhibits topoisomerase II and its function in
evaluation                                 C25214                         C25214 (evaluation)     C25214      ligating cleaved DNA molecules, resulting in
                                                                                                              Systematic, objective appraisal of the
                                                                                                  (evaluation) significance, effectiveness, and impact of
                                                                                                               activities or condition according to specified
                                                                                                               objectives and criteria.

Evan_Syndrome                              C61284                         C61284                  C61284
                                                                          (Evan_Syndrome )        (Evan_Syn
                                                                                                  drome )



ex vivo                                    C70676                         C70676 (ex vivo)        C70676       Outside the living body; referring to the use or
                                                                                                  (ex vivo)    positioning of an organ, tissue, or cell in an
                                                                                                               environment outside the living organism while
                                                                                                               the tissue or cells remain viable.
Concept                Synonym     CUI       Note                   Concantenation          Concanten Definition                                                Form      Question
                                                                    Values Only             ation                                                                         Number
                                                                                            Formula


exocrine gland                     C12712                           C12712 (exocrine        C12712
                                                                    gland)                  (exocrine
                                                                                            gland)



extent                             C25332                           C25332 (extent)         C25332
                                                                                            (extent)




Extra-Articular                    C70636                           C70636 (Extra-          C70636
                                                                    Articular)              (Extra-
                                                                                            Articular)



Extramedullary                     C25503                           C25503                  C25503      Outside of, or unrelated to, any medulla,
                                                                    (Extramedullary )       (Extramedul especially the medulla oblongata.
                                                                                            lary )



eye                                C12401                           C12401 (eye)            C12401
                                                                                            (eye)




Failure                            C25745                           C25745 (failure)        C25745         loss of ability to function normally.                   2900
                                                                                            (Failure)




Farmer                             C75559                           C75559(Farmer)          C75559         A person who produces food by growing plants
                                                                                            (Farmer)       or tending animals.




female                             C16576                           C16576 (female)         C16576         A person who belongs to the sex that normally
                                                                                            (female)       produces ova. The term is used to indicate
                                                                                                           biological sex distinctions, or cultural gender
                                                                                                           role distinctions, or both. The term
                                                                                                           "female_gender" only applies to cultural
Femoral Vein                       C12716                           C12716 (Femoral         C12716         distinctions.starts within the inguinal region and
                                                                                                           A vein that
                                                                    Vein)                   (Femoral       extends to the lower extremities.
                                                                                            Vein)



Final                              C25508                           C25508 final            C25508         NCI|Conclusive in a process or progression.             2100
                                                                                            (Final)




Finding                evidence    C3367                            C3367 (Finding )        C3367          Objective evidence of disease perceptible to
                                                                                            (Finding )     the examining physician (sign) and subjective
                                                                                                           evidence of disease perceived by the patient
                                                                                                           (symptom).

First                              C25509                           C25509 (First)          C25509         Preceding all others in time or space or
                                                                                            (First)        degree.




FLT3 Ligand                        C20492                           C20492 (FLT3 Ligand C20492             Flt3 ligand is a novel hematopoietic growth
                                                                    )                   (FLT3              factor ligand for the FLT3 tyrosine kinase
                                                                                        Ligand )           receptor. This growth factor stimulates the
                                                                                                           proliferation of hematopoietic progenitor cells.
                                                                                                           FLT3 (FLK2) is a tyrosine kinase receptor
Fluorescence in situ   FISH        C17563    Use this concept for   C17563 (Fluorescence C17563            A physical related to CSF1 and KIT. (from
                                                                                                           structurallymapping approach that uses
Hybridization                                FISH per Doug Rizzo    in situ Hybridization ) (Fluorescen    fluorescent tags to detect hybridization of
                                             8/26/08sc.                                     ce in situ     probes within metaphase chromosomes or
                                                                                            Hybridizatio   less condensed somatic interphase chromatin.
                                                                                            n)             This technique can be used for identification of
Fluorescent Antibody   Immunofluore C17370                          C17370 (Fluorescent     C17370         An immunological techniqueand for gene
                                                                                                           chromosomal abnormalities in which the
Technique              scence                                       Antibody Technique )    (Fluorescen antibodies are coupled with molecules which
                                                                                            t Antibody fluoresce under ultra violet (UV) light. This
                                                                                            Technique ) makes them particularly suitable for detection
                                                                                                        of specific antigens in tissues or on cells.
Fresh                              C75531                           C75531(Fresh)           C75531         Not previously used.
                                                                                            (Fresh)
Concept                     Synonym      CUI      Note                   Concantenation             Concanten Definition                                               Form      Question
                                                                         Values Only                ation                                                                        Number
                                                                                                    Formula


Fungi                                    C14209                          C14209 (Fungi )            C14209         A kingdom of eukaryotic, heterotrophic
                                                                                                    (Fungi )       organisms that live as saprobes or parasites,
                                                                                                                   including mushrooms, yeasts, smuts, molds,
                                                                                                                   etc. They reproduce either sexually or
                                                                                                                   asexually, and have life cycles that range from
gastrointestinal tract                   C34082                          C34082                     C34082         simple to complex. Filamentous fungi refer to
                                                                         (gastrointestinal tract)   (gastrointes
                                                                                                    tinal tract)



Gemtuzumab Ozogamicin                    C1806                           C1806 (Gemtuzumab C1806                   A recombinant, humanized anti-CD33
                                                                         Ozogamicin )      (Gemtuzum               monoclonal antibody attached to the cytotoxic
                                                                                           ab                      antitumor antibiotic calicheamicin. In this
                                                                                           Ozogamicin              conjugate, the antibody binds to and is
                                                                                           )                       internalized by tumor cells expressing CD33
Gender                                   C17357                          C17357 (Gender)            C17357         antigen (a sialic acid-dependent glycoprotein
                                                                                                    (Gender)




Genetic                                  C17938                          C17938 (Genetic)           C17938         Inherited; having to do with information that is
                                                                                                    (Genetic)      passed from parents to offspring through
                                                                                                                   genes in sperm and egg cells.



grade                                    C48309                          C48309 (grade)             C48309
                                                                                                    (grade)




Graft                       Transplant   C12981   use (NCI-gloss)        C12981 (Graft)             C12981         NCI-GLOSS|Healthy skin, bone, or other tissue
                                                  definition for Graft                              (Graft)        taken from one part of the body and used to
                                                                                                                   replace diseased or injured tissue removed
                                                                                                                   from another part of the body.

Graft Versus Host Disease   GVHD         C3063                           C3063 (Graft Versus        C3063          NCI|An incompatibility reaction (which may be
                                                                         Host Disease)              (Graft         fatal) in a subject (host) of low immunological
                                                                                                    Versus Host    competence (deficient lymphoid tissue) who
                                                                                                    Disease)       has been the recipient of immunologically
                                                                                                                   competent lymphoid tissue from a donor who
Gram per Square Meter       Gram per     C67282                          C67282 (Gram per           C67282         lacks at least of areal density defined as a
                                                                                                                   A metric unit one antigen possessed by the
                            Meter                                        Square Meter )             (Gram per      spread rate at which one gram of a substance
                            Squared                                                                 Square         is spread over the area of one square meter. It
                                                                                                    Meter )        is equal to approximately 0.029 4935 ounce
                                                                                                                   per square yard. Also used as a dose
Granulocytic Sarcoma                     C35815                          C35815 (Granulocytic       C35815         calculation unit to express quantity of an
                                                                                                                   A tumor mass composed of myeloblasts,agent
                                                                         Sarcoma )                  (Granulocyti neutrophils and neutrophil precursors.
                                                                                                    c Sarcoma ) Granulocytic sarcoma is the most common
                                                                                                                 type of myeloid sarcoma. (WHO, 2001) -- 2003

Greater Than                             C61584                          C61584 (Greater Than C61584               A statement about the relative size or order of
                                                                         )                    (Greater             two objects specifying that an object of interest
                                                                                              Than )               exceeds another object in quantity or measure
                                                                                                                   or value or status.

Greater than or Equal to                 C61583                          C61583 (Greater than       C61583         NCI|A statement about the relative size or             2100              45
                                                                         or Equal to)               (Greater       order of two objects specifying that either both
                                                                                                    than or        objects are the same in quantity or measure or
                                                                                                    Equal to)      value or status or that the object of interest
                                                                                                                   exceeds the other object in one of these ways.
heart disorder                           C3079                           C3079 (heart disorder) C3079
                                                                                                (heart
                                                                                                disorder)



Hematocrit                  HCT          C64796                          C64796 (hematocrit)        C64796      NCI|A measure of the volume of red blood                  2100              53
                                                                                                    (Hematocrit cells expressed as a percentage of the total
                                                                                                    )           blood volume. Normal in males is 43-49%, in
                                                                                                                females 37-43%.

Hematologic                              C62780                          C62780 (Hematologic C62780
                                                                         )                   (Hematologi
                                                                                             c)



Hematopoietic Stem Cell     HSC          C12551                          C12551 (Hematopoietic c12551
                                                                         Stem Cell)            (Hematopoi
                                                                                               etic Stem
                                                                                               Cell)
Concept                          Synonym     CUI        Note                   Concantenation           Concanten Definition                                             Form      Question
                                                                               Values Only              ation                                                                      Number
                                                                                                        Formula


Hematopoietic Stem Cell          HSCT                                          C12551 (Hematopoietic                  Primitive blood cells derived from embryonic
Transplantation                                                                Stem Cell), C15342                     mesenchyme capable of differentiating into any
                                                                               (Transplantation )                     of the blood cell line progenitor cells
                                                                                                                      (erythroblasts, young granulocytic series cells,
                                                                                                                      megakaryocytes, etc.)_The replacement of
Hematopoietic_Growth_Facto                   C20427                            C20427                C20427           tissue with tissue from the person's own body
                                                                                                                      NCI|Endogenous growth factors which                   2100                9
r                                                                              (Hematopoietic_Growth (Hematopoi promote the development of blood cells.
                                                                               _Factor )             etic_Growth
                                                                                                     _Factor)

Hemoglobin                                   C16676                            C16676 (hemoglobin)      C16676     NCI|The red respiratory protein of erythrocytes,         2100               52
                                                                                                        (Hemoglobi consisting of approximately 3.8% heme and
                                                                                                        n)         96.2% globin (64.5 KD), which as
                                                                                                                   oxyhemoglobin (HbO2) transports oxygen from
                                                                                                                   the lungs to the tissues where the oxygen is
Hemoglobinopathy                             C3092                             C3092                    C3092      readily released and HbO2 becomes Hb.
                                                                               (Hemoglobinopathy )      (Hemoglobi
                                                                                                        nopathy )



Hemolytic Uremic Syndrome                    C75545                            C75545(Hemolytic         C75545     A form of thrombotic microangiopathy with
                                                                               Uremic Syndrome)         (Hemolytic renal failure, hemolytic anemia, and severe
                                                                                                        Uremic     thrombocytopenia and purpura
                                                                                                        Syndrome)

Hemolytic_Anemia                             C34376                            C34376                   C34376
                                                                               (Hemolytic_Anemia )      (Hemolytic_
                                                                                                        Anemia )



Hemorrhage                                   C26791                            C26791 (Hemorrhage ) C26791
                                                                                                    (Hemorrhag
                                                                                                    e)



Hemorrhagic Cyst                             C75548                            C75548(Hemorrhagic       C75548     A cyst containing blood.
                                                                               Cyst)                    (Hemorrhag
                                                                                                        ic Cyst)



Hepatic Disorder                             C3196                             C3196 (Hepatic           C3196         NCI|Any disease or dysfunction of the liver and
                                                                               Disorder)                (Hepatic      the intrahepatic bile ducts.
                                                                                                        Disorder)



Hepatitis                                    C3095                             C3095 (Hepatitis)        C3095         Inflammation of the liver; usually from a viral
                                                                                                        (Hepatitis)   infection, but sometimes from toxic agents.



                                                                                                                      NCI|HSV is a nuclear replicating, icosahedral,
Herpes_Simplex_Virus                         C14311                            C14311                C14311           enveloped DNA virus. The HSV envelope                 2100              432
                                                                               Herpes_Simplex_Virus, (Herpes_Si       contains at least 8 glycoproteins. The matrix or
                                                                                                     mplex_Viru       tegument which contacts both the envelope
                                                                                                     s)               and the capsid contains at least 15-20
                                                                                                                      proteins. There are two types of HSV - Type 1
High-grade B-cell lymphoma                   C6817                             C6817 (High-grade B-     C6817
                                                                               cell lymphoma)           (High-grade
                                                                                                        B-cell
                                                                                                        lymphoma)

Histiocytic and Dendritic Cell               C9294                             C9294 (Histiocytic and C9294
Neoplasms                                                                      Dendritic Cell         (Histiocytic
                                                                               Neoplasms)             and
                                                                                                      Dendritic
                                                                                                      Cell
history                                      C54625                            C54625 (history)       Neoplasms)
                                                                                                      C54625
                                                                                                        (history)




HLA                                                     When refering to HLA C20706 (MHC Class I                      Found on virtually every cell, MHC (Major
                                                        in general, combine the Protein-HLA), C20705                  Histocompatibility, HLA) Class-I (Antigens)
                                                        terms for MHC Class I (MHC Class II Protein )                 Proteins consist of noncovalently bound
                                                        and II proteins.                                              polymorphic 44-kDa MHC membrane
                                                                                                                      glycoprotein and nonpolymorphic 12-kDa b2-
HLA Matching                     HLA Testing , C68707                          C68707 (HLA              C68707        A process by whichHLA antigens are encoded
                                                                                                                      microglobulin. The a donor's blood or tissue
                                 HLA                                           Matching)                (HLA          sample is analyzed to determine its human
                                 Compatibility                                                          Matching)     leukocyte antigen (HLA) profile so that it can
                                 Testing                                                                              be transplanted into a patient with the same
                                                                                                                      profile.
Concept               Synonym   CUI      Note   Concantenation         Concanten Definition                                             Form      Question
                                                Values Only            ation                                                                      Number
                                                                       Formula


HLA-A Gene                      C28585          C28585 (HLA-A Gene) C28585
                                                                    (HLA-A
                                                                    Gene)



HLA-B Gene                      C62778          C62778 (HLA-B Gene) C62778
                                                                    (HLA-B
                                                                    Gene)



HLA-C_Gene                      C62758          C62758 (HLA-C_Gene) C62758
                                                                    (HLA-
                                                                    C_Gene)



HLA-DPB1_Gene                   C29953          C29953 (HLA-           C29953
                                                DPB1_Gene)             (HLA-
                                                                       DPB1_Gen
                                                                       e)

HLA-DQ Antigen                  C62792          C62792 (HLA-DQ         C62792         Polymorphic glycoproteins which are
                                                Antigen )              (HLA-DQ        expressed primarily in lymphoid cells and
                                                                       Antigen )      function to present antigens for CD4+ T
                                                                                      lymphocytes. Certain HLA-DQ protein variants
                                                                                      are associated with susceptibility to insulin-
HLA-DQB1 Gene                   C70614          C70614 (HLA-DQB1       C70614         dependent diabetes mellitus and several
                                                                                      This gene is involved in the mediation of
                                                Gene )                 (HLA-DQB1 antigen presentation.
                                                                       Gene )



HLA-DR Antigen                  C16692          C16692 (HLA-DR         C16692         |Encoded by multiple HLA-DRA and HLA-DRB
                                                Antigen)               (HLA-DR        genes in a complex variable 5 cM region of
                                                                       Antigen)       MHC between HLA-B and -D, HLA-DR
                                                                                      Antigens are Class II histocompatibility
                                                                                      transmembrane glycoprotein heterodimers of
HLA-DRB1 Gene                   C19409          C19409 (HLA-DRB1       C19409         alpha (heavy, 35-kD) and beta (light, 27-kD)
                                                Gene)                  (HLA-DRB1
                                                                       Gene)



Hodgkin Lymphoma                C9357           C9357 (Hodgkin         C9357
                                                Lymphoma)              (Hodgkin
                                                                       Lymphoma)



Homemaker                       C75560          C75560(Homemaker)      C75560   A person who manages a home as their main
                                                                       (Homemak daily activity.
                                                                       er)



Hospitalization                 C25179          C25179                 C25179       The condition of being treated as a patient in a
                                                (Hospitalization )     (Hospitaliza hospital.
                                                                       tion )



Human_Herpesvirus_6   HHV-6     C14218          C14218              C14218            NCI|A human herpesvirus that has been found          2100              433
                                                Human_Herpesvirus_6 (Human_He         in certain lymphoproliferative disorders,
                                                                    rpesvirus_6       replicates in a number of different types of
                                                                    )                 leukocytes, and is associated with the
                                                                                      childhood disease roseola (exanthema
Hydroxyurea                     C560            C560 (Hydroxyurea)     C560           subitum).|On-line Medical Dictionary
                                                                       (Hydroxyure
                                                                       a)



hypertension                    C3117           C3117 (hypertension)   C3117       Abnormally high blood pressure
                                                                       (hypertensi
                                                                       on)



idarubicin                      C562            C562 (idarubicin)      C562         A semisynthetic, 4-demethoxy analogue of the
                                                                       (idarubicin) anthracycline antineoplastic antibiotic,
                                                                                    daunorubicin. Idarubicin intercalates into DNA
                                                                                    and interferes with the activity of
                                                                                    topoisomerase II, thereby inhibiting DNA
Identical                       C49034          C49034 (Identical )    C49034       replication, RNA transcription and protein
                                                                                    Exactly alike; incapable of being perceived as
                                                                       (Identical )   different; being the exact same one; coinciding
                                                                                      exactly when superimposed; having properties
                                                                                      with uniform values along all axes.
Concept                       Synonym    CUI      Note                   Concantenation         Concanten Definition                                                  Form      Question
                                                                         Values Only            ation                                                                           Number
                                                                                                Formula


Identifier                               C25364                          C25364 (Identifier )   C25364          One or more characters used to identify,
                                                                                                (Identifier )   name, or characterize the nature, properties,
                                                                                                                or contents of a thing.



Idiopathic                               C28242                          C28242 (Idiopathic )   C28242        NCI-GLOSS|Describes a disease of unknown
                                                                                                (Idiopathic ) cause.




Idiopathic Pneumonia                     C62590                          C62590(Idiopathic   C62590             An inflammatory lung disease characterized by
Syndrome                                                                 Pneumonia Syndrome) (Idiopathic        diffuse interstitial pneumonitis and alveolitis
                                                                                             Pneumonia          leading to interstitial fibrosis in the absence of
                                                                                             Syndrome)          an identifiable infectious agent.

Idiopathic_Pneumonia_Syndr               C62590                          C62590                C62590           NCI|An inflammatory lung disease                         2100              420
ome                                                                      Idiopathic_Pneumonia_ (Idiopathic_     characterized by diffuse interstitial pneumonitis
                                                                         Syndrome              Pneumonia        and alveolitis leading to interstitial fibrosis in
                                                                                               _Syndrome)       the absence of an identifiable infectious agent.

Idiopathic_Thrombocytopenic              C3446                           C3446                  C3446           Thrombocytopenia occurring in the absence of
_Purpura                                                                 (Idiopathic_Thrombocyt (Idiopathic_    toxic exposure or a disease associated with
                                                                         openic_Purpura )       Thrombocyt      decreased platelets. It is mediated by immune
                                                                                                openic_Pur      mechanisms, in most cases
                                                                                                pura )          IMMUNOGLOBULIN G autoantibodies which
imanitib mesylate                        C1687                           C1687 (imanitib        C1687           attach to platelets and subsequently undergo
                                                                         mesylate)              (imanitib
                                                                                                mesylate)



Imatinib Mesylate             Gleevec    C1687                           C1687 (Imatinib        C1687           The mesylate salt of imatinib, a tyrosine kinase
                                                                         Mesylate)              (Imatinib       inhibitor with antiproliferative activity. Imatinib
                                                                                                Mesylate)       binds to an intracellular pocket located within
                                                                                                                tyrosine kinases (TK), thereby inhibiting ATP
                                                                                                                binding and preventing phosphorylation and
Immune_System_and_Relate Immunodefici C27351                             C27351               C27351            the subsequent activation of growth receptors
d_Disorders              ency and                                        (Immune_System_and (Immune_S
                         Immunosupp                                      _Related_Disorders ) ystem_and_
                         ression                                                              Related_Dis
                         Disorders                                                            orders )
Immunoglobulin                           C572                            C572 (Immunoglobulin) C572       NCI|Any of the structurally related                            2100
                                                                                               (Immunoglo glycoproteins that function as antibodies. They
                                                                                               bulin)     are divided into five classes (IGA, IGD, IGE,
                                                                                                          IGG, IGM) on the basis of structure and
                                                                                                          biological activity.
Immunomagnetic beads                              combine the concepts   C16406 (Cell                           Techniques and methods for separating cells
                                                  for cell sorting and   Sorting):C71606                        (usually viable) based on a variety of criteria
                                                  immunomagnetic         (Immunomagnetic                        for separation, such as size or density, non-
                                                  column                 Column )                               specific surface properties, or specific surface
                                                                                                                properties. Examples include cell affinity
Inborn_Errors_of_Metabolism Congenital   C34816                          C34816                C34816           chromatography and centrifugation using
                                                                                                                Errors in metabolic processes resulting from
                            Metabolic                                    (Inborn_Errors_of_Met (Inborn_Err inborn genetic mutations that are inherited or
                            Disorder                                     abolism)              ors_of_Met acquired in utero.
                                                                                               abolism)

Inclusion                                C25532                          C25532 (Inclusion)     C25532          The addition of somebody or something to, or
                                                                                                (Inclusion)     the presence of somebody or something in, a
                                                                                                                group or mixture.



Inconclusive                             C75569                          C75569(Inconclusive)   C75569       Not putting an end to doubt or question;
                                                                                                (Inconclusiv leading to no final results or outcome.
                                                                                                e)



Increase                                 C25533                          C25533 (Increase)      C25533
                                                                                                (Increase)




Ind-2                                    C38147                          C38147 (Ind-2)         C38147
                                                                                                (Ind-2)




Infectious Disorder                      C26726                          C26726 (Infectious     C26726
                                                                         Disorder)              (Infectious
                                                                                                Disorder)
Concept                        Synonym    CUI      Note   Concantenation          Concanten Definition                                                 Form      Question
                                                          Values Only             ation                                                                          Number
                                                                                  Formula


Inflammation                              C3137           C3137 (Inflammation)    C3137
                                                                                  (Inflammatio
                                                                                  n)



Inflammatory Bowel Disease                C3138           C3138 (Inflammatory     C3138
                                                          Bowel Disease)          (Inflammato
                                                                                  ry Bowel
                                                                                  Disease)

Infliximab                     Remicade   C1789           C1789 (Infliximab )     C1789         A recombinant chimeric, mouse-human                       2400              152
                                                                                  (Infliximab ) monoclonal antibody directed against tumor
                                                                                                necrosis factor alpha (TNF-alpha), a protein
                                                                                                involved in inflammation, cell survival, and
                                                                                                apoptosis. Infliximab may be pro- apoptotic or
Infusion Procedure             Infusion   C15388          C15388 (Infusion        C15388        anti-apoptotic, depending on cell type. (NCI04)
                                                                                                A method of putting fluids, including drugs, into
                                                          Procedure )             (Infusion   the bloodstream. Also called intravenous
                                                                                  Procedure ) infusion.



Inpatient                                 C25182          C25182 (Inpatient )     C25182         A patient who is residing in the hospital where
                                                                                  (Inpatient )   he is being treated.




Institution                               C41206          C41206 (Institution)    C41206        An established society, corporation, foundation
                                                                                  (Institution) or other organization founded and united for a
                                                                                                specific purpose, e.g. for health-related
                                                                                                research; also used to refer to a building or
                                                                                                buildings occupied or used by such
Integer                                   C45255          C45255 (Integer )       C45255        organization. no fractional part, including the
                                                                                                A number with
                                                                                  (Integer )     negative and positive numbers as well as zero.




intensity                                 C25539          C25539 (intensity)      C25539
                                                                                  (intensity)




Intent                                    C25725          C25725 (Intent)         C25725         An anticipated outcome that is the meaning or
                                                                                  (Intent)       purpose for actions taken, thus guiding your
                                                                                                 planned actions.



interferon                                C2049           C2049 (interferon)      C2049
                                                                                  (interferon)




Internal Jugular Vein                     C32849          C32849 (Internal        C32849
                                                          Jugular Vein )          (Internal
                                                                                  Jugular
                                                                                  Vein )

International Staging System              C70657          C70657 (International   C70657       A method of staging myeloma published by the
for Myeloma                                               Staging System for      (Internation International Myeloma Working Group in 2003.
                                                          Myeloma)                al Staging
                                                                                  System for
                                                                                  Myeloma)
Intracranial_Hemorrhage                   C50438          C50438                 C50438        FDA|Bleeding within the cranium, which may                 2900
                                                          (Intracranial_Hemorrha (Intracranial be extradural, subdural, subarachnoid, or
                                                          ge)                    _Hemorrha cerebral.
                                                                                 ge )

Intrathecal Chemotherapy                  C15750          C15750 (Intrathecal     C15750
                                                          Chemotherapy)           (Intrathecal
                                                                                  Chemother
                                                                                  apy)

Intrathecal Route of                      C38267          C38267 (Intrathecal     C38267         Administration of drugs directly into spinal
Administration                                            Route of Administration (Intrathecal   subarachnoid space in the cerebrospinal fluid,
                                                          )                       Route of       at any level of the cerebrospinal axis, including
                                                                                  Administrati   injection into the cerebral ventricles, in order to
                                                                                  on )           bypass the blood-brain barrier and achieve
Intravenous Route of           IV         C38276          C38276 (Intravenous C38276             Administration of a on the meninges or vein or
                                                                                                 local, rapid effects drug within or into a
Administration                                            Route of Administration (Intravenou    veins. Introduction of the drug directly into
                                                          )                       s Route of     venous circulation results in 100%
                                                                                  Administrati   bioavailability due to an absence of the
                                                                                  on )           absorption phase, provides a precise and
                                                                                                 continuous mode of drug therapy, especially
Concept                      Synonym   CUI      Note   Concantenation          Concanten Definition                                                 Form      Question
                                                       Values Only             ation                                                                          Number
                                                                               Formula


invasive                               C14159          C14159 (invasive)       C14159
                                                                               (invasive)




isolation                              C25549          C25549 isolation        C25549         NCI|A state of separation; the act of isolating          2100              429
                                                                               (isolation)    something; setting something apart from
                                                                                              others; marked by separation of or from usually
                                                                                              contiguous elements.

ISS Stage I Plasma Cell                C70658          C70658 (ISS Stage I     C70658         Plasma cell myeloma with beta-2-microglobulin
Myeloma                                                Plasma Cell Myeloma)    (ISS Stage I   less than 3.5 and albumin greater than or
                                                                               Plasma Cell    equal to 3.5 (median survival of 62 months).
                                                                               Myeloma)       Note that the older Durie/Salmon staging
                                                                                              system defines stage I quite differently. (PDQ)
ISS Stage II Plasma Cell               C70659          C70659 (ISS Stage II    C70659         Plasma cell myeloma with beta-2-microglobulin
Myeloma                                                Plasma Cell Myeloma)    (ISS Stage     less than 3.5 and albumin less than 3.5 or beta-
                                                                               II Plasma      2-microglobulin 3.5 to less than 5.5 (median
                                                                               Cell           survival of 44 months). Note that the older
                                                                               Myeloma)       Durie/Salmon staging system defines stage II
ISS Stage III Plasma Cell              C70660          C70660 (ISS Stage III   C70660         quite differently. (PDQ)
                                                                                              Plasma cell myeloma with beta-2-microglobulin
Myeloma                                                Plasma Cell Myeloma)    (ISS Stage     greater than or equal to 5.5 (median survival of
                                                                               III Plasma     29 months). Note that the older Durie/Salmon
                                                                               Cell           staging system defines stage III quite
                                                                               Myeloma)       differently. (PDQ)
juvenile myelomonocytic                C9233           C9233 (juvenile         C9233
leukemia (JMML)                                        myelomonocytic          (juvenile
                                                       leukemia (JMML))        myelomono
                                                                               cytic
                                                                               leukemia
Juvenile_Myelomonocytic_Le             C9233           C9233                   (JMML))
                                                                               C9233
ukemia                                                 (Juvenile_Myelomonoc (Juvenile_M
                                                       ytic_Leukemia )      yelomonocy
                                                                            tic_Leukemi
                                                                            a)
Karnofsky Performance                  C28013          C28013 (Karnofsky       C28013         A standard way of measuring the ability of
Status                                                 Performance Status )    (Karnofsky     cancer patients to perform ordinary tasks. The
                                                                               Performanc     scores range from 0 to 100, with a higher
                                                                               e Status )     score indicating a better ability to carry out
                                                                                              daily activities. KPS may be used to determine
Lab Lupus Inhibitor                    C70648          C70648 (Lab Lupus       C70648         a patient's prognosis, to measure changes in
                                                       Inhibitor)              (Lab Lupus
                                                                               Inhibitor)



Laboratory Finding                     C38470          C38470 (Laboratory      C38470      The result of a lab test to measure an attribute
                                                       Finding )               (Laboratory or to determine the presence, absence or
                                                                               Finding )   degree of a condition.



laboratory procedure                   C25294          C25294 (laboratory      C25294         A medical procedure that involves testing a
                                                       procedure)              (laboratory    sample of blood, urine, or other substance
                                                                               procedure)     from the body. Tests can help determine a
                                                                                              diagnosis, plan treatment, check to see if
                                                                                              treatment is working, or monitor the disease
Laborer                                C75556          C75556(Laborer)         C75556         over time. who works with their hands;
                                                                                              Someone
                                                                               (Laborer)      someone engaged in manual labor.




Lansky Play-Performance                C38144          C38144 (Lansky Play- C38144            The play-performance scale for children is a
Status                                                 Performance Status ) (Lansky           parent-rated instrument which records usual
                                                                            Play-             play activity as the index of performance. It is
                                                                            Performanc        similar to the Karnofsky Performance Scale for
                                                                            e Status )        adults.
last                                   C25551          C25551 last             C25551                                                                  2100              420
                                                                               (last)


                                                                                              NCI|Coming after all others in time or space or degree or being the only one remaining.
lenalidomide                           C2668           C2668 (lenalidomide)    C2668
                                                                               (lenalidomid
                                                                               e)



Less Than or Equal To                  C61586          C61586 (Less Than or C61586            A statement about the relative size or order of
                                                       Equal To )           (Less Than        two objects specifying that either both objects
                                                                            or Equal To       are the same in quantity or measure or value
                                                                            )                 or status or that the object of interest is smaller
                                                                                              than the other object in one of these ways.
Concept                         Synonym       CUI      Note   Concantenation          Concanten Definition                                                 Form      Question
                                                              Values Only             ation                                                                          Number
                                                                                      Formula


Less_than                                     C61585          C61585 (less than)      C61585      NCI|A statement about the relative size or
                                                                                      (Less_than) order of two objects specifying that an object of
                                                                                                  interest is smaller than another object in
                                                                                                  quantity or measure or value or status.

Leukapheresis                                 C15269          C15269 leukapheresis C15269     NCI-GLOSS|Removal of the blood to collect                       2100
                                                                                   (Leukapher specific blood cells; the remaining blood is
                                                                                   esis)      returned to the body.



leukemia                                      C3161           C3161 (leukemia)        C3161
                                                                                      (leukemia)




Leukocyte                       White blood   C12529          C12529 (Leukocyte )     C12529     Blood cells that are devoid of hemoglobin,
                                cell                                                  (Leukocyte capable of ameboid motion and fagocytosis,
                                                                                      )          and act as the principal components of the
                                                                                                 immune system.

Level                                         C2554           C2554 (Level)           C2554          Degree
                                                                                      (Level)




Life                                          C37987          C37987 (Life )          C37987         The organic phenomenon that distinguishes
                                                                                      (Life )        living organisms from nonliving ones; showing
                                                                                                     characteristics of life.



Life Threatening or Disabling                 C41337          C41337 (Life            C41337         Any adverse event that places the patient, in
Adverse Event                                                 Threatening or          (Life          the view of the initial reporter, at immediate risk
                                                              Disabling Adverse       Threatening    of death from the adverse event as it occurred,
                                                              Event )                 or Disabling   i.e., it does not include an adverse experience
                                                                                      Adverse        that, had it occurred in a more severe form,
local                                         C67263          C67263 (local )         Event )
                                                                                      C67263         Of or belonging to adeath.
                                                                                                     might have caused restricted area or locality
                                                                                      (local )




local therapy                                 C15687          C15687 (local therapy) C15687
                                                                                     (local
                                                                                     therapy)



Lung                                          C12468          C12468 (Lung)           C12468
                                                                                      (Lung)




Lung Carcinoma                  Lung Cancer C4878             C4878 (Lung           C4878       A carcinoma originating in the lung. Lung
                                                              Carcinoma )           (Lung       carcinomas usually arise from the epithelium
                                                                                    Carcinoma ) that lines the bronchial tree (bronchogenic
                                                                                                carcinomas), and are classified as small cell or
                                                                                                non-small cell carcinomas. Non-small cell lung
Lung Disorder                                 C3198           C3198 (Lung Disorder) C3198       carcinomas are usually adenocarcinomas,
                                                                                    (Lung
                                                                                    Disorder)



Lung_Tissue                     Lung       C33024             C33024 (Lung_Tissue) C33024     Tissue consisting of an external serous coat,
                                Parenchyma                                         (Lung_Tiss subserous areolar tissue and lung
                                                                                   ue)        parenchyma. The parenchyma is made up of
                                                                                              lobules wound together by connective tissue. A
                                                                                              primary lobule consists of a terminal
Lupus Anticoagulant Antibody                  C70620          C70620 (Lupus        C70620     bronchiole, respiratory bronchioles, and
                                                              Anticoagulant Antibody) (Lupus
                                                                                      Anticoagula
                                                                                      nt Antibody)

lymphoma                                      C3208           C3208 (lymphoma)        C3208
                                                                                      (lymphoma)




lymphoplasmacytic                             C3212           C3212                   C3212
lymphoma/Waldenstrom                                          (lymphoplasmacytic      (lymphoplas
macroglobulinemia                                             lymphoma/Waldenstro     macytic
                                                              m macroglobulinemia)    lymphoma/
                                                                                      Waldenstro
                                                                                      m
Concept                     Synonym   CUI      Note   Concantenation         Concanten Definition                                                   Form      Question
                                                      Values Only            ation                                                                            Number
                                                                             Formula


Maculopapular Lesion                                                         C75579       A skin condition consisting of both macules
                                                                             (Maculopap and papules.
                                                                             ular Lesion)
                                                      C75579(Maculopapular
                                      C75579          Lesion)
Maintenance Therapy                   C15688          C15688 (Maintenance C15688             Treatment that is given to help a primary
                                                      Therapy )            (Maintenan        (original) treatment keep working. Maintenance
                                                                           ce Therapy        therapy is often given to help keep cancer in
                                                                           )                 remission.

male                                  C20197          C20197 (male)          C20197          A person who belongs to the sex that normally
                                                                             (male)          produces sperm. The term is used to indicate
                                                                                             biological sex distinctions, cultural gender role
                                                                                             distinctions, or both. The term "male_gender"
                                                                                             only applies to cultural distinctions.
Malignant                             C14143          C14343 (malignant)     C14143       NCI|Refers to abnormal cell activity manifested              2900
                                                                             (Malignant ) by decreased control over growth and function,
                                                                                          causing tumor growth or spread into
                                                                                          surrounding tissue and adverse effects to the
                                                                                          host.
Malignant Neoplasm          Cancer    C9305           C9305 (Malignant      C9305        A tumor composed of atypical neoplastic, often
                                                      Neoplasm )            (Malignant pleomorphic cells that invade other tissues.
                                                                            Neoplasm ) Malignant neoplasms often metastasize to
                                                                                         distant anatomic sites and may recur after
                                                                                         excision. The most common malignant
manipulation                          C48310          C48310 (manipulation) c48310       neoplasms are carcinomas (adenocarcinomas
                                                                            (manipulatio
                                                                            n)



Match                                 C54116          C54116 (Match )        C54116          An exact duplicate; coinciding in
                                                                             (Match )        characteristics; similar or consistent.




means                                 C47955          C47955 (means)         C47955
                                                                             (means)




Medication                            C459            C459 (Medication )     C459        A drug or medicine that treats or prevents or
                                                                             (Medication alleviates the symptoms of disease.
                                                                             )



Metaphase                             C16846          C16846 (Metaphase ) C16846     The second phase of mitosis, in which the
                                                                          (Metaphase chromosomes line up across the equatorial
                                                                          )          plane of the spindle prior to separation.



metastasis                            C19151          C19151 (metastasis)    C19151
                                                                             (metastasis)




Method                                C71460          C71460 (Method)        C71460          A means, manner of procedure, or systematic
                                                                             (Method)        course of actions that have to be performed in
                                                                                             order to accomplish a particular goal.



MHC Class I Protein-HLA               C20706          C20706 (MHC Class I    C20706          Found on virtually every cell, MHC (Major
                                                      Protein-HLA)           (MHC Class      Histocompatibility, HLA) Class-I (Antigens)
                                                                             I Protein-      Proteins consist of noncovalently bound
                                                                             HLA)            polymorphic 44-kDa MHC membrane
                                                                                             glycoprotein and nonpolymorphic 12-kDa b2-
MHC Class II Protein_ HLA             C20705          C20705 (MHC Class II C20705            MHC Class-II The HLA antigens are encoded
                                                                                             microglobulin.Proteins are non-covalently
                                                      Protein )            (MHC Class linked polymorphic alpha/beta transmembrane
                                                                           II Protein_ glycoproteins. The immunological function of
                                                                           HLA)        MHC Class-II proteins is to bind and present
                                                                                       antigenic peptides on the surfaces of cells for
Microscopic Polyarteritis             C70549          C70549 (Microscopic C70549       recognition by the antigen-specific T typically
                                                                                       A systemic necrotizing vasculitis that cell
                                                      Polyarteritis)         (Microscopi     affects the small and medium-sized muscular
                                                                             c               arteries. In some cases, however, microscopic
                                                                             Polyarteritis   vessels are also affected (e.g., in the kidneys),
                                                                             )               a condition that has been called microscopic
Microscopic Polyarteritis             C70549          C70549 (Microscopic    C70549          polyarteritis or polyangiitis; this disorder is felt
                                                      Polyarteritis)         (Microscopi
                                                                             c
                                                                             Polyarteritis
                                                                             )
Concept                      Synonym      CUI      Note                 Concantenation         Concanten Definition                                              Form      Question
                                                                        Values Only            ation                                                                       Number
                                                                                               Formula


Mikulicz_Disease             Sicca        C34819                        C34819                 C34819       A chronic, benign, and usually painless
                             Syndrome                                   (Mikulicz_Disease)     (Mikulicz_Di inflammatory swelling of the lacrimal and
                                                                                               sease)       salivary glands. It is considered by some to
                                                                                                            include the glandular enlargement associated
                                                                                                            with other diseases, such as Sjogren's
Mild                                      C70666                        C70666 (Mild)          C70666       syndrome, sarcoidosis, lupus erythematosus,
                                                                                               (Mild)




mismatch                                  C67078                        C67078 (mismatch)      c67078
                                                                                               (mismatch)




Missing Value Reason                      C48655                        C48655 (Missing        C48655          A specific reason explaining why a meaningful
                                                                        Value Reason )         (Missing        value is not available. A meaningful value
                                                                                               Value           answers the question posed by a Data
                                                                                               Reason )        Element Concept. In contrast, a Missing Value
                                                                                                               Reason answers the implicit question "Why is
Mitoxantrone                              C62050                        C62050 (Mitoxantrone C62050            there no 'meaningful' value?", with
                                                                                                               An anthracenedione antibiotic when there is
                                                                        )                    (Mitoxantro antineoplastic activity. Mitoxantrone
                                                                                             ne )        intercalates into and crosslinks DNA, thereby
                                                                                                         disrupting DNA and RNA replication. This
                                                                                                         agent also binds to topoisomerase II, resulting
mixed                                     C25259                        C25259 mixed         C25259      NCI|Involving or composed of different DNA
                                                                                                         in DNA strand breaks and inhibition of kinds.              2100
                                                                                               (mixed)




Mobilized Peripheral Blood                C75576                        C75576(Mobilized      C75576           Blood stem cells found in the circulation after
Stem Cell                                                               Peripheral Blood Stem (Mobilized       being stimulated to leave the bone marrow,
                                                                        Cell)                 Peripheral       usually by treatment with a cytokine or other
                                                                                              Blood Stem       drug.
                                                                                              Cell)
Moderate                                  C61376                        C61376 (Moderate)      C61376
                                                                                               (Moderate)




Molecular Analysis           Molecular    C19770                        C19770 (Molecular      C19770          Techniques for studying or analyzing the
                             Technique,                                 Analysis )             (Molecular      genetic composition and mechanisms of living
                             molecular                                                         Analysis )      organisms at the molecular level. May refer to
                             marker                                                                            the understanding and manipulation of genes
                                                                                                               (DNA).
Molecular Remission                                                     C19770 (Molecular      (Molecular
                                                                        Analysis ), C18246     Remission)
                                                                        (remission)



Molecular_Genetic_Abnormal                C36391                        C36391                C36391
ity                                                                     (Molecular_Genetic_Ab (Molecular_
                                                                        normality )           Genetic_Ab
                                                                                              normality )

Monoclonal Antibody                       C20401                        C20401 (Monoclonal     C20401      An antibody produced by a clone or genetically
                                                                        Antibody )             (Monoclonal homogenous fast-growing cells i.e., hybridoma.
                                                                                               Antibody ) Hybridoma cells are cloned to establish cell
                                                                                                           lines producing a specific antibody that is
                                                                                                           chemically and immunologically homogeneous.
mononeuritis multiplex                    C70938                        C70938 (mononeuritis   C70938      They are widely used in cancer detection,
                                                                        multiplex)             (mononeurit
                                                                                               is multiplex)



Mononucleated Blood Cell                  C73123   Added to EVS on 18   C73123               C73123            A mixture of cells possessing a single nucleus,      2006              145
                                                   March 2008           (Mononucleated Blood (Mononucle        including monocytes and lymphocytes; blood
                                                                        Cell )               ated Blood        leukocytes from which granulocytes have been
                                                                                             Cell )            separated and removed.

Monosomy 17                               C36509                        C36509 (Monosomy       C36509
                                                                        17)                    (Monosomy
                                                                                               17)



Monosomy 5                                C36523                        C36523 (Monosomy 5) C36523
                                                                                            (Monosomy
                                                                                            5)
Concept                        Synonym   CUI      Note   Concantenation        Concanten Definition                                           Form      Question
                                                         Values Only           ation                                                                    Number
                                                                               Formula


Monosomy 7                               C36411          C36411 (Monosomy 7) C36411    A chromosomal abnormality consisting of the               2011              14
                                                                             (Monosomy absence of one of the copies of chromosome 7
                                                                             7)        in somatic cells.



Monosomy X                               C36630          C36630 (Monosomy X) C36630    no definition
                                                                             (Monosomy
                                                                             X)



multiple                                 C17648          C17648 (multiple)     C17648        NCI|Having, relating to, or consisting of more
                                                                               (multiple)    than one individual, element, part, or other
                                                                                             component; manifold. (dictionary.com)



Multiple Myeloma-IgA                     C70606          C70606 (Multiple      C70606
                                                         Myeloma-IgA)          (Multiple
                                                                               Myeloma-
                                                                               IgA)

Multiple Myeloma-IgD                     C70607          C70607 (Multiple      C70607
                                                         Myeloma-IgD)          (Multiple
                                                                               Myeloma-
                                                                               IgD)

Multiple Myeloma-IgE                     C70608          C70608 (Multiple      C70608
                                                         Myeloma-IgE)          (Multiple
                                                                               Myeloma-
                                                                               IgE)




Multiple Myeloma-IgG                     C70609          C70609 (Multiple      C70609
                                                         Myeloma-IgG)          (Multiple
                                                                               Myeloma-
                                                                               IgG)

Multiple Myeloma-IgM (not                C70610          C70610 (Multiple      C70610
Waldenstrom                                              Myeloma-IgM (not      (Multiple
Macroglobulinemia)                                       Waldenstrom           Myeloma-
                                                         Macroglobulinemia))   IgM (not
                                                                               Waldenstro
Multiple Myeloma-Light Chain             C70605          C70605 (Multiple      m
                                                                               C70605
Only                                                     Myeloma-Light Chain   (Multiple
                                                         Only)                 Myeloma-
                                                                               Light Chain
                                                                               Only)
multiple sclerosis                       C3243           C3243 (multiple       C3243
                                                         sclerosis)            (multiple
                                                                               sclerosis)



Multiple Sclerosis                       C3243           C3243 (Multiple       C3243
                                                         Sclerosis)            (Multiple
                                                                               Sclerosis)



muromonab-CD3                  OKT-3     C1321                                 C1321     A murine IgG2a monoclonal antibody with                 2006              83
                                                                               (muromona potential immunosuppressive activity.
                                                                               b-CD3)    Muromonab-CD3 specifically targets and binds
                                                                                         to the T-cell receptor CD3 complex on the
                                                                                         surface of circulating T-lymphocytes, which
Muscle Contracture                       C75585          C75585(Muscle         C75585    mediates antigen recognition process. a result
                                                                                         Permanent contraction of a muscle as Binding
                                                         Contracture)          (Muscle     of spasm or paralysis.
                                                                               Contracture
                                                                               )
Concept                         Synonym      CUI      Note                  Concantenation           Concanten Definition                                               Form      Question
                                                                            Values Only              ation                                                                        Number
                                                                                                     Formula


Mutation                                     C16885                         C16885 (Mutation )       C16885          Permanent, transmissible changes in the
                                                                                                     (Mutation )     genetic material of an organism. Mutations can
                                                                                                                     range from a single base change to the loss of
                                                                                                                     a significant portion of a chromosome. These
                                                                                                                     occur when DNA is not repaired prior to
Myasthenia_Gravis                            C60989                         C60989                   C60989          replication. Mutations in germ cells can be
                                                                            (Myasthenia_Gravis)      (Myasthenia
                                                                                                     _Gravis)



Myeloablative Chemotherapy                   C16231   Do not use the concept C16231 (Myeloablative C16231            The administration of high-dose                       2400              113
                                                      C1711 (Myeloablative Chemotherapy )          (Myeloablati      chemotherapy, with or without total body
                                                      Agonist )                                    ve                irradiation, to eradicate the underlying disease
                                                                                                   Chemother         and/or ablate the immune system of the
                                                                                                   apy )             patient.
Myelodysplastic Syndrome                     C3247                          C3247                    C3247           A clonal hematopoietic disorder characterized
                                                                            (Myelodysplastic         (Myelodyspl     by dysplasia and ineffective hematopoiesis in
                                                                            Syndrome )               astic           one or more of the hematopoietic cell lines.
                                                                                                     Syndrome )      The dysplasia may be accompanied by an
                                                                                                                     increase in myeloblasts, but the number is less
Myelodysplastic_myeloprolifer                C27262                         C27262                   C27262          than 20%, which, according to the WHO
ative disease (MDS)                                                         (Myelodysplastic_myelo   (Myelodyspl
                                                                            proliferative disease    astic_myelo
                                                                            (MDS))                   proliferative
                                                                                                     disease
Myelodysplastic_Syndrome                     C3247                          C3247                    (MDS))
                                                                                                     C3247
                                                                            (Myelodysplastic_Syndr (Myelodyspl
                                                                            ome )                  astic_Syndr
                                                                                                   ome )

Myeloperoxidase                              C71145                         C71145                   C71145     Myeloperoxidase (745 aa, ~84 kDa) is
                                                                            (Myeloperoxidase )       (Myelopero encoded by the human MPO gene. This
                                                                                                     xidase )   protein is involved in innate host defense by
                                                                                                                facilitating the oxygen-dependent mechanism
                                                                                                                of apoptosis.
Name                                         C42614                         C42614 (Name)            C42614          The words or language units by which a thing
                                                                                                     (Name)          is known.




Necrotizing Vasculitis                       C70635                         C70635 (Necrotizing      C70635
                                                                            Vasculitis)              (Necrotizing
                                                                                                     Vasculitis)



Negative Selection                           C70599                         C70599 (Negative         C70599
                                                                            Selection)               (Negative
                                                                                                     Selection)



Neoadjuvant Therapy             Induction    C15665                         C15665 (Neoadjuvant C15665       Treatment given before the primary treatment.
                                Therapy                                     Therapy )           (Neoadjuva Examples of neoadjuvant therapy include
                                                                                                nt Therapy ) chemotherapy, radiation therapy, and hormone
                                                                                                             therapy.

                                CD56         C25276                         C25276                C25276             NCI|Neural Cell Adhesion Molecule is a                2100               76
                                Antigen                                     (Neural Cell Adhesion (Neural            membrane-bound glycoprotein member of the
                                                                            Molecule)             Cell               Ig superfamily that binds to a variety of other
Neural Cell Adhesion                                                                              Adhesion           cell adhesion proteins involved in diverse
Molecule                                                                                          Molecule)          contact-mediated interactions. NCAM appears
Next                            Subsequent   C53286                         C53286 (Next)            C53286          Subsequent; immediately following in timein the
                                                                                                                     on early embryonic cells and is important or
                                                                                                     (Next)          order.




nilotinib                                    C48375                         C48375 (nilotinib)       C48375
                                                                                                     (nilotinib)




Nodular Partial Remission                    C70633                         C70633 (Nodular          C70633
                                                                            Partial Remission)       (Nodular
                                                                                                     Partial
                                                                                                     Remission)

Non Hodgkin's Lymphoma                       C3211                          C3211 (Non Hodgkin's C3211
                                                                            Lymphoma)            (Non
                                                                                                 Hodgkin's
                                                                                                 Lymphoma)
Concept                        Synonym     CUI      Note                 Concantenation           Concanten Definition                                             Form      Question
                                                                         Values Only              ation                                                                      Number
                                                                                                  Formula


Non-Neoplastic Heart                       C3079                         C3079 (Non-Neoplastic C3079 (Non-
Disorder                                                                 Heart Disorder)       Neoplastic
                                                                                               Heart
                                                                                               Disorder)

Non-Secretory Myeloma                      C4734                         C4734 (Non-Secretory C4734 (Non-
                                                                         Myeloma)             Secretory
                                                                                              Myeloma)



normal                                     C14165                        C14165 (normal)          C14165
                                                                                                  (normal)




not                            Negation,   C25594                        C25594 (not)             C25594       An operation in which a term denies or inverts
                               non-                                                               (not)        the meaning of another term or construction.




Not Applicable                             C48660                        C48660 (Not              C48660       Determination of a value is not relevant in the
                                                                         Applicable )             (Not         current context.
                                                                                                  Applicable )



Not Identified                             C48661                        C48661 (not identified) C48661        NCI|The finding is not present, but a value of         2900
                                                                                                 (Not          'none' cannot be unequivocally established
                                                                                                 Identified)   absence in the current context.



not otherwise specified                    C19594                        C19594 (not otherwise C19594          NCI|Not characterized in any other way.
                                                                         specified)            (not
                                                                                               otherwise
                                                                                               specified)

Nucleated Blood Cell                       C73126   Added to EVS on 18   C73126 (Nucleated        C73126       The cellular material of blood consisting of           2006              144
                                                    March 2010           Blood Cell )             (Nucleated white blood cells and nucleated red blood cells.
                                                                                                  Blood Cell )



Nucleated Red Blood Cell                   C73125   Added to EVS on 18   C73125 (Nucleated        C73125       Red blood cells that are at the last stage of          2006              146
                                                    March 2009           Red Blood Cell )         (Nucleated   development, still containing a nucleus, that
                                                                                                  Red Blood    are found in the bone marrow and occasionally
                                                                                                  Cell )       in the peripheral blood.

number                                     C25337                        C25337 (number)          C25337
                                                                                                  (number)




obesity                                    C3283                         C3283 (obesity)          C3283
                                                                                                  (obesity)




Obesity                                    C3283                         C3283 (Obesity)          C3283
                                                                                                  (Obesity)




occurrence                                 C25275                        C25275 (occurrence)      C25275      An instance of something happening, such as
                                                                                                  (occurrence an event or incident.
                                                                                                  )



Onset                                      C25279                        C25279 (Onset )          C25279       The start, beginning, or early stages.
                                                                                                  (Onset )




Open Lung Biopsy                           C51923                        C51923                   C51923     NCI|Removal of tissue from the lung, for                 2100              425
                                                                         Open_Lung_Biopsy         (Open Lung microscopic examination, obtained during an
                                                                                                  Biopsy )   open surgical procedure.



Oral Route of Administration               C38288                        C38288 (Oral Route of C38288          The introduction of a substance to the mouth
                                                                         Administration )      (Oral Route     or into the gastrointestinal tract by the way of
                                                                                               of              the mouth, usually for systemic action. It is the
                                                                                               Administrati    most common, convenient, and usually the
                                                                                               on )            safest and least expensive route of drug
                                                                                                               administration, but it uses the most
Concept                         Synonym     CUI       Note   Concantenation           Concanten Definition                                               Form      Question
                                                             Values Only              ation                                                                        Number
                                                                                      Formula


Organ                                       C13018           C13018 (organ)           C13018         NCI|A unique macroscopic (gross) anatomic              2900
                                                                                      (Organ)        structure that performs specific functions. It is
                                                                                                     composed of various tissues. An organ is part
                                                                                                     of an anatomic system or a body region.
                                                                                                     Representative examples include the heart,
Organism                                    C14250           C14250 (Organism)        C14250         lung, liver, spleen, andan animal, a plant, a
                                                                                                     A living thing, such as uterus.
                                                                                      (Organism) bacterium, or a fungus.




Organizational Unit             Organization C41167          C41167                   C41167       Organizational unit like a laboratory, institute or
                                                             (Organizational Unit )   (Organizatio consortium.
                                                                                      nal Unit )



osteopetrosis                               C26840           C26840 (osteopetrosis) C26840
                                                                                    (osteopetro
                                                                                    sis)



other                                       C17649           C17649 (other)           c17649
                                                                                      (other)




Overlap_Necrotizing_Arteritis               C61282           C61282                C61282
                                                             (Overlap_Necrotizing_ (Overlap_N
                                                             Arteritis )           ecrotizing_
                                                                                   Arteritis )

p-ANCA IFA                                                   C17370 (Fluorescent       (p-ANCA                                                              2400              454
                                                             Antibody Technique ),    IFA)
                                                             C71145
                                                             (Myeloperoxidase ),
                                                             C16295 (antibody)
p-ANCA Positive                                              C17998 (Unknown),        (p-ANCA                                                               2400              469
                                                             C25294 (laboratory       Positive)
                                                             procedure), C71145
                                                             (Myeloperoxidase ),
                                                             C16295 (antibody)
Parainfluenza Virus                         C75532           C75532(Parainfluenza C75532       Any of several paramyxoviruses (genus
                                                             Virus)               (Parainfluen Respirovirus and Rubulavirus) that are a
                                                                                  za Virus)    frequent cause of infections of the lower
                                                                                               respiratory tract.

Paraproteinemia                             C27468           C27468                   C27468      A plasma cell disorder in which an abnormal
                                                             (Paraproteinemia)        (Paraprotei amount of a single immunoglobulin is present
                                                                                      nemia)      in the serum. Paraproteinemias may be seen
                                                                                                  in conjunction with various carcinomas, chronic
                                                                                                  inflammatory and infectious conditions, and
Part Time Employment                        C75562           C75562(Part Time         C75562      other diseases
                                                                                                  Employment involving less than the standard
                                                             Employment)              (Part Time or customary working time.
                                                                                      Employmen
                                                                                      t)

Partial Remission               Partial     C18058           C18058 (Partial          C18058     A decrease in the size of a tumor, or in the
                                Response                     Remission)               (Partial   extent of cancer in the body, in response to
                                                                                      Remission) treatment.



Partial Response of Multiple                C70641           C70641 (Partial          C70641
Myeloma or Plasma Cell                                       Response of Multiple     (Partial
Leukemia                                                     Myeloma or Plasma        Response
                                                             Cell Leukemia)           of Multiple
                                                                                      Myeloma or
Pathology                                   C18189           C18189 (Pathology)       Plasma Cell NCI|The medical science, and specialty
                                                                                      C18189                                                                2100              568
                                                                                      (Pathology) practice, concerned with all aspects of disease,
                                                                                                  but with special reference to the essential
                                                                                                  nature, causes, and development of abnormal
                                                                                                  conditions, as well as the structural and
Patient                                     C16960           C16960 (Patient )        C16960      functional changes that result from the disease
                                                                                                  A person who receives medical attention, care,
                                                                                      (Patient )     or treatment, or who is registered with medical
                                                                                                     professional or institution with the purpose to
                                                                                                     receive medical care when necessary.

Pediatric                       Childhood   C39299           C39299 (Pediatric )      C39299         NCI-GLOSS|(pee-dee-AT-rik) Having to do
                                                                                      (Pediatric )   with children.
Concept                     Synonym   CUI      Note   Concantenation         Concanten Definition                                               Form      Question
                                                      Values Only            ation                                                                        Number
                                                                             Formula


pending                               C53470          C53470 (pending)       C53470        NCI|Not yet decided or settled; awaiting                2900
                                                                             (pending)     conclusion or confirmation.|Dictionary.com




Peptic Ulcer                          C3318           C3318 (Peptic Ulcer)   C3318
                                                                             (Peptic
                                                                             Ulcer)



Per                                   C65039          C65039 (Per )          C65039
                                                                             (Per )




Percentage                            C25613          C25613 (Percentage)    C25613     A fraction or ratio with 100 understood as the
                                                                             (Percentag denominator.
                                                                             e)



Performance Status                    C20641          C20641 (Performance C20641      A measure of how well a patient is able to
                                                      Status )            (Performan perform ordinary tasks and carry out daily
                                                                          ce Status ) activities.



Performed                             C38000          C38000 (Performed)     C38000      Executed and carried through to completion.
                                                                             (Performed)




Peripheral_Nervous_System             C12465          C12465                C12465       That part of the nervous system consisting of
                                                      (Peripheral_Nervous_S (Peripheral_ the nerves and neurons that reside or extend
                                                      ystem)                Nervous_S outside the central nervous system.
                                                                            ystem)

Ph -/BCR-ABL-                         C70629          C70629 (Ph -/BCR-      C70629 (Ph
                                                      ABL-)                  -/BCR-ABL-
                                                                             )



Ph Unknown/BCR-                       C70627          C70627 (Ph             C70627 (Ph
                                                      Unknown/BCR-)          Unknown/B
                                                                             CR-)



Ph Unknown/BCR Unknown                C70628          C70628 (Ph             C70628 (Ph
                                                      Unknown/BCR            Unknown/B
                                                      Unknown)               CR
                                                                             Unknown)

Ph Unknown/BCR+                       C70623          C70623 (Ph             C70623 (Ph
                                                      Unknown/BCR+)          Unknown/B
                                                                             CR+)



Ph-/BCR Unknown                       C70630          C70630 (Ph-/BCR        C70630 (Ph-
                                                      Unknown)               /BCR
                                                                             Unknown)



Ph-/BCR+                              C70602          C70602 (Ph-/BCR+)      C70602 (Ph-
                                                                             /BCR+)




Ph+/BCR Unknown                       C70624          C70624 (Ph+/BCR        C70624
                                                      Unknown)               (Ph+/BCR
                                                                             Unknown)



Pharmacological_Treatment             C15986          C15986                C15986      Treatment of disease through the use of drugs.
                                                      (Pharmacological_Trea (Pharmacol
                                                      tment)                ogical_Trea
                                                                            tment)

                                      C1909                                C1909           NCI|An active natural, synthetic or semi-               2100
                                                                           (Pharmalogi     synthetic ingredient including endogenous
                                                      C1909                c_Substanc      body substance that is intended to furnish
                                                      (Pharmalogic_Substan e)              pharmacological activity or other direct effect in
Pharmalogic_Substance                                 ce)                                  the diagnosis, cure, mitigation, treatment, or                            33
                                                                                           prevention of disease or to affect the structure
Concept                   Synonym   CUI      Note   Concantenation          Concanten Definition                                                  Form      Question
                                                    Values Only             ation                                                                           Number
                                                                            Formula


phase                               C25257          C25257 (phase)          C25257
                                                                            (phase)




Philadelphia Chromosome             C28452          C28452 (Philadelphia    C28452
                                                    Chromosome)             (Philadelphi
                                                                            a
                                                                            Chromoso
                                                                            me)
philadelphia chromosome             C9128           C9128 (philadelphia     C9128
positive CM                                         chromosome positive     (philadelphi
                                                    CM)                     a
                                                                            chromosom
                                                                            e positive
Planned                             C25619          C25619 (Planned)        CM)
                                                                            C25619       To devise, contrive, or formed in design.
                                                                            (Planned)




plasma cell                         C12486          C12486 (plasma cell)    C12486
                                                                            (plasma
                                                                            cell)



Plasma Cell Myeloma                 C3242           C3242 (Plasma Cell      C3242          NCI|A bone marrow-based plasma cell
                                                    Myeloma )               (Plasma        neoplasm characterized by a serum
                                                                            Cell           monoclonal protein and skeletal destruction
                                                                            Myeloma )      with osteolytic lesions, pathological fractures,
                                                                                           bone pain, hypercalcemia, and anemia.
platelet                            C12520          C12520 (platelet)       C12520         Clinical variants include non-secretory
                                                                            (platelet)




Platelet count                      C51951          C51951 (platelet count) C51951         NCI|The determination of the number of
                                                                            (Platelet      platelets in a blood sample, usually expressed
                                                                            count)         as platelets per cubic millimeter (cmm) of
                                                                                           whole blood.

platelet count 20000                C53266          C53266 (platelet count C53266          NCI|Indicates a platelet count of at least                2100              45
                                                    20000)                 (platelet       20,000 per cubic millimeter.
                                                                           count
                                                                           20000)

platelet count 50000                C53267          C53267 (platelet count C53267                                                                    2100              46
                                                    50000)                 (platelet
                                                                           count
                                                                           50000)          NCI|Indicates a platelet count of at least 50,000
                                                                                           per cubic millimeter.
Platelet Transfusion                C15366          C15366(Platelet         C15366      The infusion of platelets into the bloodstream.
                                                    Transfusion)            (Platelet
                                                                            Transfusion
                                                                            )

Polymyositis                        C26925          C26925 (Polymyositis ) C26925
                                                                           (Polymyositi
                                                                           s)



Positive Selection                  C71257          C71257 (Positive        C71257         The separation of specific cells or cell
                                                    Selection )             (Positive      populations from a heterogeneous mixture.
                                                                            Selection )    Specifically it refers to the selective retention of
                                                                                           a population of desired cells through
                                                                                           recognition of cells bearing the specified
post                                C38008          C38008 (post)           C38008         characteristics. following a point or another
                                                                                           The time period
                                                                            (post)         period of time.




preparative regimen                 C61155          C61155 (preparative     C61155       The chemotherapy and/or radiation given to
                                                    regimen)                (preparative bone marrow transplant patients prior to
                                                                            regimen)     transplant to kill diseased cells and/or make
                                                                                         space for healthy new marrow and/or suppress
                                                                                         the immune system so graft rejection does not
Present                   In        C25626          C25626 (Present)        C25626       occur.
                                                                                         Being or existing in a specified place or at the
                                                                            (Present)      specified time.
Concept                         Synonym      CUI       Note                 Concantenation          Concanten Definition                                              Form      Question
                                                                            Values Only             ation                                                                       Number
                                                                                                    Formula


Preventative Intervention                    C15843                         C15843 (Preventative    C15843
                                                                            Intervention)           (Preventativ
                                                                                                    e
                                                                                                    Intervention
                                                                                                    )
Previous                                     C25627                         C25627 (Previous)       C25627         Occurring prior to something else.
                                                                                                    (Previous)




Primary                                      C25251                         C25251 (Primary)        C25251
                                                                                                    (Primary)




Primary Induction Failure                    C70622                         C70622 (Primary         C70622
                                                                            Induction Failure)      (Primary
                                                                                                    Induction
                                                                                                    Failure)

Primary Refractory (Less than                C70604                         C70604 (Primary         C70604
Partial Response (PR) to                                                    Refractory (Less than   (Primary
Initial Therapy) / Primary                                                  Partial Response (PR)   Refractory
Induction Failure-Resistant                                                 to Initial Therapy) /   (Less than
(PIF Res)                                                                   Primary Induction       Partial
prior                           pre          C25629                         C25629 (prior) (PIF
                                                                            Failure-Resistant       Response
                                                                                                    c25629
                                                                                                    (prior)



                                                                                                                   NCI|Earlier in time or order._NCI|A tumor
Prior Malignancy                History of   C25629,                        C25629 (Prior), C9305                  composed of atypical neoplastic, often
                                Malignancy   C9305                          (Malignant Neoplasm)                   pleomorphic cells that invade other tissues.
                                                                                                                   Malignant neoplasms often metastasize to distant
                                                                                                                   anatomic sites and may recur after excision. The
                                                                                                                   most common malignant neoplasms are
                                                                                                                   carcinomas (adenocarcinomas or squamous cell
Processing                      Processing   C48177                         C48177 (Processing ) C48177      The act of preparing or putting through a
                                Technique                                                        (Processing prescribed procedure.
                                                                                                 )



Professional Occupation                      C75558                         C75558(Professional     C75558      An occupation requiring special education,
                                                                            Occupation)             (Profession especially in the liberal arts or sciences.
                                                                                                    al
                                                                                                    Occupation)

Progression of Multiple                      C70643                         C70643 (Progression C70643
Myeloma or Plasma Cell                                                      of Multiple Myeloma or (Progressio
Leukemia                                                                    Plasma Cell Leukemia) n of Multiple
                                                                                                   Myeloma or
                                                                                                   Plasma Cell
Progressive Disease                          C35571                                                Leukemia)
                                                                            C35571 (Progressive C35571
                                                                            Disease)                (Progressiv
                                                                                                    e Disease)



Propidium Iodide                             C72903    Added to EVS on 13   C72903 ( Propidium      C72903         A fluorescent nucleic acid dye which binds only       2006              152
                                                       March 2012           Iodide )                (Propidium     to double-stranded nucleic acids. It has a
                                                                                                    Iodide )       molecular weight of 668.4, an absorbance
                                                                                                                   maximum of 535nm, and an emission
                                                                                                                   maximum of 617 nm. It is commonly used to
Proteinase-3                                 C17548                         C17548 (Proteinase-3) C17548           Encoded by human content of a cell or to
                                                                                                                   determine the DNA PRTN3 Gene (Peptidase
                                                                                                  (Proteinase- S1 Family), 256-aa 29-kD Proteinase 3
                                                                                                  3)           precursor is coordinately expressed with and
                                                                                                               packed in neutrophilic azurophil granules with
                                                                                                               ELA2 and AZU during myeloid development.
protocol                                     C42651                         C42651 (protocol)     C42651       A rule which neutral serine activity should be
                                                                                                               An antibiotic guides how anprotease, PRTN3
                                                                                                    (protocol)     performed.




Protozoal Infection                          C34953                         C34953 (Protozoal       C34953         MSH2003_2003_05_12|Infections with                    2900
                                                                            Infection)              (Protozoal     unicellular organisms of the subkingdom
                                                                                                    Infection)     PROTOZOA.



Proximal                                     C25236                         C25236 (Proximal )      C25236         NCI-GLOSS|In medicine, refers to a part of the
                                                                                                    (Proximal )    body that is closer to the center of the body
                                                                                                                   than another part. For example, the knee is
                                                                                                                   proximal to the toes. The opposite is distal.
Concept                      Synonym       CUI      Note   Concantenation           Concanten Definition                                               Form      Question
                                                           Values Only              ation                                                                        Number
                                                                                    Formula


Psoriasis                                  C3346           C3346 (Psoriasis )       C3346
                                                                                    (Psoriasis )




Psoriatic_Arthritis                        C61277          C61277                   C61277
                                                           (Psoriatic_Arthritis )   (Psoriatic_A
                                                                                    rthritis )



Psychiatric Disorder                       C2893           C2893 (Psychiatric       C2893
                                                           Disorder)                (Psychiatric
                                                                                    Disorder)



Pulmonary                                  C13304          C13304 (Pulmonary)       C13304
                                                                                    (Pulmonary)




Pulmonary hypertension                     C3120           C3120 (Pulmonary         C3120       Increased pressure within the pulmonary
                                                           hypertension)            (Pulmonary circulation, usually secondary to cardiac or
                                                                                    hypertensio pulmonary disease
                                                                                    n)

Pulmonary_Fibrosis                         C26869          C26869                   C26869     Chronic inflammation and progressive fibrosis
                                                           (Pulmonary_Fibrosis)     (Pulmonary of the pulmonary alveolar walls, with steadily
                                                                                    _Fibrosis) progressive dyspnea, resulting finally in death
                                                                                               from oxygen lack or right heart failure.

Purpose                                    C25634          C25634 (Purpose )        C25634         What something is used for; reason or
                                                                                    (Purpose )     intention.




radiation therapy                          C1533           C1533 (radiation         C1533
                                                           therapy)                 (radiation
                                                                                    therapy)



Radiography                                C38101          C38101(Radiography)      C38101     A radiographic procedure using the emission
                                                                                    (Radiograp of x-rays to form an image of the structure
                                                                                    hy)        penetrated by the radiation.



Radiolabeled                               C18138          C18138 (Radiolabeled C18138      Any compound that has been joined with a
                                                           )                    (Radiolabel radioactive substance.
                                                                                ed )



Reaction                                   C25637          C25637 (Reaction)        C25637         Reaction; a bodily process occurring due to the
                                                                                    (Reaction)     effect of some foregoing stimulus or agent.




reason                                     C25638          C25638 (reason)          C25638                                                                2900
                                                                                    (reason)

                                                                                                   NCI|An explanation of the cause of some
                                                                                                   phenomenon or action.
recipient                                  C53268          C53268 (recipient)       C53268
                                                                                    (recipient)




Recombinant Granulocyte-     GM-CSF        C1288           C1288 (Recombinant       C1288        NCI|A recombinant therapeutic agent which is             2100              9
Macrophage Colony-                                         Granulocyte-             (Recombina chemically identical to or similar to the
Stimulating Factor                                         Macrophage Colony-       nt           endogenous glycoprotein cytokine growth
                                                           Stimulating Factor )     Granulocyte- factor granulocyte-macrophage colony
                                                                                    Macrophag stimulating factor (GM-CSF). Therapeutic GM-
Recombinant Human            Palifermin,   C2455           C2455 (Recombinant       e Colony-
                                                                                    C2455        NCI|A recombinant formexpansion and
                                                                                                 CSF induces the clonal of the endogenous                 2100              9
Keratinocyte Growth Factor   Kepivance,                    Human Keratinocyte       (Recombina     human keratinocyte growth factor with cell
                             KGF                           Growth Factor)           nt Human       growth promoting activity. Palifermin acts in the
                                                                                    Keratinocyt    manner similar to the endogenous keratinocyte
                                                                                    e Growth       growth factor that binds to keratinocyte growth
Recombinant_Granulocyte_C G-CSF            C1287           C1287                    Factor)
                                                                                    C1287          factor recombinant therapeutic agent which in
                                                                                                   NCI|A receptors on the epithelial cell surfaceis       2100              9
olony_Stimulating_Factor                                   Recombinant_Granuloc (Recombina chemically identical to or similar to the
                                                           yte_Colony_Stimulating nt_Granuloc endogenous cytokine granulocyte colony-
                                                           _Factor                yte_Colony stimulating factor (G-CSF). Secreted by
                                                                                  _Stimulatin monocytes, macrophages and neutrophils and
                                                                                  g_Factor)   other cells after activation, G-CSF stimulates
Concept                  Synonym     CUI       Note   Concantenation          Concanten Definition                                               Form      Question
                                                      Values Only             ation                                                                        Number
                                                                              Formula


recovery                             C25746           C25746 (recovery)       C25746        NCI|A healing process and/or an outcome                 2100              45
                                                                              (recovery)    implying relative health. The term is typically
                                                                                            used in the context of direct and indirect effects
                                                                                            of sickness or injury.

Recurrent                            C14173           C14173 (Recurrent)      C14173
                                                                              (Recurrent)




Recurrent_Disease        relapse     C38155           C38155                  C38155      The return of a disease after a period of
                                                      (Recurrent_Disease)     (Recurrent_ remission.
                                                                              Disease)



reduced                  reduction   C25640           C25640 (reduced)        C25640
                                                                              (reduced)




registry                             C61393           C61393 (registry)       C61393
                                                                              (registry)




Relapse from Complete                C70645           C70645 (Relapse from    C70645
Response of Multiple                                  Complete Response of    (Relapse
Myeloma or Plasma Cell                                Multiple Myeloma or     from
Leukemia                                              Plasma Cell Leukemia)   Complete
                                                                              Response
Related                  Relationship C25648          C25648 (Related)        of Multiple
                                                                              C25648        A state of connectedness between people,
                                                                              (Related)     objects, or events; to be associated or
                                                                                            connected with something.



Relative                             C21480           C21480 (Relative )      C21480        A person related by blood or marriage.
                                                                              (Relative )




remission                            C18246           C18246 (remission)      C18246
                                                                              (remission)




Remove                               C64914           C64914 (Remove )        C64914        Shift the position or location of; take out of.
                                                                              (Remove )




renal                                C25225           C25225 (renal)          C25225        Of or pertaining to the kidney.
                                                                              (renal)




Renal Disorder                       C3149            C3149 (Renal            C3149
                                                      Disorder)               (Renal
                                                                              Disorder)



Renal failure                        C4376            C4376 (Renal failure)   C4376         NCI|Acute or chronic condition, characterized           2900
                                                                              (Renal        by the inability of the kidneys to adequately
                                                                              failure)      filter the blood substances, resulting in uremia
                                                                                            and electrolyte imbalances. Acute renal failure
                                                                                            is usually associated with oliguria or anuria,
Report                               C25375           C25375 (Report)         C25375        hyperkalemia, and pulmonary edema. Chronic
                                                                                            A short textual account; having provided a
                                                                              (Report)      short account.




Representation                       C67045           C67045                  C67045     NCI|An activity that stands as an equivalent of
                                                      (Representation)        (Represent something or results in an equivalent; typical
                                                                              ation)     of, or the same as, others in a larger group of
                                                                                         people or things.

Research                             C15319           C15319 (Research)       C15319     Systematic investigation into a subject in order
                                                                              (Research) to discover facts, to establish or revise a
                                                                                         theory, or to develop a plan of action based on
                                                                                         the facts discovered.
Concept                       Synonym   CUI      Note                 Concantenation           Concanten Definition                                              Form      Question
                                                                      Values Only              ation                                                                       Number
                                                                                               Formula


Respiratory_Syncytial_Virus   RSV       C14267                        C14267 RSV               C14267       NCI-GLOSS|A virus that causes respiratory               2100              435
                                                                                               (Respiratory infections with cold-like symptoms.
                                                                                               _Syncytial_
                                                                                               Virus )

Response_Evaluation_Criteri RECIST      C49164                        C49164                   C49164         Standard parameters to be used when
a_in_Solid_Tumors                                                     (Response_Evaluation     (Response_     documenting response of solid tumors to
                                                                      _Criteria_in_Solid_Tum   Evaluation_    treatment; a set of published rules that define
                                                                      ors )                    Criteria_in_   when cancer patients improve ("respond"),
                                                                                               Solid_Tumo     stay the same ("stable"), or worsen
Rheumatoid_Arthritis                    C2884                         C2884                    rs )
                                                                                               C2884          ("progression") during treatments. (from
                                                                      (Rheumatoid_Arthritis ) (Rheumatoi
                                                                                              d_Arthritis )



Rheumatologic Disorder                  C27204                        C27204                   C27204
                                                                      (Rheumatologic           (Rheumatol
                                                                      Disorder)                ogic
                                                                                               Disorder)

rituximab                               C1702                         C1702 (rituximab)        C1702
                                                                                               (rituximab)




Route of Administration                 C38114                        C38114 (Route of         C38114         Designation of the part of the body through
                                                                      Administration )         (Route of      which or into which, or the way in which, the
                                                                                               Administrati   medicinal product is intended to be introduced.
                                                                                               on )           In some cases a medicinal product can be
                                                                                                              intended for more than one route and/or
Salesperson                             C75553                        C75553(Salesperson       C75553         method ofemployed to sell goods or services
                                                                                                              A person administration.|ICH
syn: Selling Occupation                                               syn: Selling             (Salesperso especially to customers in a store or to
                                                                      Occupation)              n            customers that are visited within a geographic
                                                                                               syn: Selling area.
                                                                                               Occupation)
Same                                    C64637   Be sure to use the    C64637 (Same )          C64637         Equal, or closely similar or comparable, in kind
                                                 definition specified                          (Same )        or quality or quantity or degree.
                                                 here. As of 13 March
                                                 2008, this was the
                                                 caDSR definition and
Same                                    C64637   not the NCI Thesaurus C64637 (Same )          C64637
                                                                                               (Same )




                                                                                           C75527
                                                                                           (Schirmer
                                                                      C75527(Schirmer Test Test
Schirmer Test Wetting                                                 Wetting              Wetting            An indication of the amount of moisture
Synonym: Wetting                        C75527                        Synonym: Wetting)    Synonym:           collected on a filter paper strip in 5 minutes.
Scl 70 Positive                                                       C16516               Wetting)
                                                                                            (Scl 70
                                                                      (Topoisomerase I),       Positive)
                                                                      C16295 (antibody)



Second                                  C25666                        C25666 (Second)          C25666         Coming next after the first in position in space
                                                                                               (Second)       or time or degree or magnitude.




Secondary                               C25667                        C25667 (Secondary)       C25667
                                                                                               (Secondary)




Sedimentation                           C54178   Do not use conept    C54178                   C54178      The act or process of settling particles by              2006               51
                                                 C559 (Hetastarch)    (Sedimentation )         (Sedimentat mechanical means from a state of suspension
                                                                                               ion )       in air or water.



Serological                             C41264                        C41264 (Serological)     C41264
                                                                                               (Serological
                                                                                               )



serositis                               C70428                        C70428 (serositis)       C70428         Inflammation of a serous membrane.
                                                                                               (serositis)
Concept                        Synonym   CUI      Note                 Concantenation          Concanten Definition                                             Form      Question
                                                                       Values Only             ation                                                                      Number
                                                                                               Formula


Serum                                    C13325                        C13325 (Serum)          C13325        The clear portion of the blood that remains
                                                                                               (Serum)       after the removal of the blood cells and the
                                                                                                             clotting proteins.



Severe                                   C70667                        C70667 (Severe)         C70667
                                                                                               (Severe)




Severe Aplastic Anemia                   C61229                        C61229 (Severe          C61229
                                                                       Aplastic Anemia)        (Severe
                                                                                               Aplastic
                                                                                               Anemia)

Severe Combined                          C61238                        C61238 (Severe          C61238
Immunodeficiency with                                                  Combined                (Severe
Absence of T and B Cells                                               Immunodeficiency with   Combined
                                                                       Absence of T and B      Immunodefi
                                                                       Cells )                 ciency with
Severe Combined                          C61239                        C61239 (Severe          C61239 of
                                                                                               Absence
Immunodeficiency with                                                  Combined            (Severe
Absence of T, Normal B Cells                                                               Combined
                                                                       Immunodeficiency with
                                                                       Absence of T, NormalImmunodefi
                                                                       B Cells )           ciency with
Severe_Combined_Immunod SCID             C3472                         C3472               Absence
                                                                                           C3472 of X-linked or autosomal recessive disorder
eficiency                                                              (Severe_Combined_Im (Severe_Co characterized by defects of both humoral and
                                                                       munodeficiency )    mbined_Im cell mediated immunity, resulting in low or
                                                                                           munodeficie absent antibody levels, leukopenia, marked
                                                                                           ncy )       susceptibility to infections, and early death.--
Sheep Red Blood Cell                     C72897   Added to EVS on 13   C72897 (Sheep Red       C72897     A technique for identifying and removing T               2006              68
Rosetting                                         March 2010           Blood Cell Rosetting)   (Sheep Red lymphocytes based on their ability to form
                                                                                               Blood Cell rosettes with untreated sheep erythrocytes.
                                                                                               Rosetting)

Sibling                                  C25204                        C25204 (Sibling )       C25204        A person's brother or sister.
                                                                                               (Sibling )




Sicca Syndrome                           C70647                        C70647 (Sicca           C70647
                                                                       Syndrome)               (Sicca
                                                                                               Syndrome)



Significant                              C41130                        C41130 (Significant )   C41130       A term applied to differences, correlations,
                                                                                               (Significant cause-and-effect relationships, etc., to indicate
                                                                                               )            that they are noticeable, probably too closely
                                                                                                            correlated to be attributed to chance and
                                                                                                            therefore indicating a systematic relation:
Sjogren_s_Syndrome                       C26883                        C26883                  C26883       substantial, fairly large; also having
                                                                                                            Chronic inflammatory and autoimmune
                                                                       (Sjogren_s_Syndrome (Sjogren_s_ disease in which the salivary and lacrimal
                                                                       )                   Syndrome ) glands undergo progressive destruction by
                                                                                                       lymphocytes and plasma cells resulting in
                                                                                                       decreased production of saliva and tears. The
Skilled Worker                           C75554                        C75554(Skilled      C75554      A worker who has called sicca syndrome,
                                                                                                       primary form, oftenacquired special skills.
                                                                       Worker)                 (Skilled
                                                                                               Worker)



skin                                     C12470                        C12470 (skin)           C12470
                                                                                               (skin)




Skin Rash                                C39594                        C39594 (Skin Rash)      C39594
                                                                                               (Skin Rash)




Slit-lamp Examination                    C75583                        C75583(Slit-lamp        C75583     Examination of the anterior segment of the eye
                                                                       Examination)            (Slit-lamp using a medical instrument called a slit lamp.
                                                                                               Examinatio
                                                                                               n)

Solid Tumor                              C9292                         C9292 (Solid Tumor)     C9292
                                                                                               (Solid
                                                                                               Tumor)
Concept                        Synonym     CUI      Note                 Concantenation           Concanten Definition                                                Form      Question
                                                                         Values Only              ation                                                                         Number
                                                                                                  Formula


Source                                     C25683                        C25683 (Source)          C25683
                                                                                                  (Source)




Soybean Lectin Agglutination               C72902   Added to EVS on 13   C72902 (Soybean          C72902       A technique for removing T lymphocytes based              2006              63
                                                    March 2011           Lectin Agglutination )   (Soybean     on differential agglutination with soybean lectin.
                                                                                                  Lectin
                                                                                                  Agglutinatio
                                                                                                  n)
specified                                  C38024                        C38024 (specified)       C38024
                                                                                                  (specified)




specify                                    C25685                        C25685 (specify)         C25685
                                                                                                  (specify)




Specimen                                   C19157                        C19157 (Specimen)        C19157     Specimen; a bit of tissue or blood or urine that
                                                                                                  (Specimen) is taken or used for research purposes.




Stable                                     C30103                        C30103 stable            C30103         NCI|Stable; subject to little fluctuation; showing      2100
                                                                                                  (Stable)       little if any change.




Stable Disease                             C18213                        C18213 (Stable           C18213         Cancer that is neither decreasing nor
                                                                         Disease)                 (Stable        increasing in extent or severity.
                                                                                                  Disease)



Stable Multiple Myeloma or                 C70642                        C70642 (Stable        C70642
Plasma Cell Leukemia                                                     Multiple Myeloma or   (Stable
                                                                         Plasma Cell Leukemia) Multiple
                                                                                               Myeloma or
                                                                                               Plasma Cell
stage                                      C16899                        C16899 (stage)        Leukemia) The extent of a cancer within the body,
                                                                                               C16899
                                                                                               (stage)     especially whether the disease has spread
                                                                                                           from the original site to other parts of the body.



status                                     C25688                        C25688 (status)          C25688
                                                                                                  (status)




Stem_Cell_Mobilization_Ther                C62604                        C62604 SC                C62604         NCI|Therapy to cause release of stem cells              2100
apy                                                                      mobilization therapy     (Stem_Cell     from the bone marrow into the peripheral blood
                                                                                                  _Mobilizatio   circulation for the purpose of leukapheresis,
                                                                                                  n_Therapy )    prior to stem cell transplantion. Hematopoietic
                                                                                                                 growth factors or chemotherapeutic agents
Stills disease                             C61278                        C61278 (Stills disease) C61278          often are used to stimulate the mobilization.
                                                                                                 (Stills
                                                                                                 disease)



Stringent Complete                         C70637                        C70637 (Stringent        C70637
Response (sCR) of Multiple                                               Complete Response        (Stringent
Myeloma or Plasma Cell                                                   (sCR) of Multiple        Complete
Leukemia                                                                 Myeloma or Plasma        Response
                                                                         Cell Leukemia)           (sCR) of
Student                                    C75561                        C75561(Student)          Multiple
                                                                                                  C75561         A person who is enrolled in an educational
                                                                                                  (Student)      institution.




Subclavian Vein                            C12794                        C12794 (Subclavian       C12794      The continuation of the axillary vein which
                                                                         Vein )                   (Subclavian follows the subclavian artery and then joins the
                                                                                                  Vein )      internal jugular vein to form the
                                                                                                              brachiocephalic vein.

Submission                     Submitted   C25695                        C25695 (Submission)      C25695     Referred for judgment or consideration;
                                                                                                  (Submissio handed over.
                                                                                                  n)
Concept                  Synonym     CUI        Note                  Concantenation          Concanten Definition                                            Form      Question
                                                                      Values Only             ation                                                                     Number
                                                                                              Formula


subtype                              C25696                           C25696 (subtype)        C25696
                                                                                              (subtype)




Suicide                              C3394                                                    C3394         NCI|The act of ending one's own life.                2900
                                                                                              (Suicide)




Susceptibility           Predispositio C16505                         C16505 (Susceptibility C16505        The constitutional or inborn state disposing to
                         n                                            )                      (Susceptibili a disease, group of diseases, or metabolic or
                                                                                             ty )          structural anomaly.



swelling                             C3399                            C3399 (swelling)        C3399
                                                                                              (swelling)




Syndrome                             C28193                           C28193 (Syndrome)       C28193     A set of symptoms or conditions that occur
                                                                                              (Syndrome) together and suggest the presence of a certain
                                                                                                         disease or an increased chance of developing
                                                                                                         the disease.

systemic                             C13310                           C13310 (systemic)       C13310        Affecting an entire system.
                                                                                              (systemic)




Systemic sclerosis                              This is the way that   C13310 (systemic),    (Systemic      Affecting an entire system._chronic hardening
                                                Doug wants the term    C26746 (scleroderma) sclerosis)      and thickening of the skin caused by swelling
                                                curated. For                                                and thickening of fibrous tissue leading to
                                                scleroderma be sure to                                      eventual atrophy of the epidermis; can occur
                                                use the specified                                           as a localized or a systemic disease.
Systemic Therapy                     C15698     definition. In the NCI C15698 (Systemic     C15698          (sis-TEM-ik THER-a-pee) Treatment using
                                                                       Therapy )            (Systemic       substances that travel through the
                                                                                            Therapy )       bloodstream, reaching and affecting cells all
                                                                                                            over the body.

Systemic_Lupus_Erythemato SLE        C3201                            C3201                 C3201           A chronic inflammatory connective tissue
sus                                                                   (Systemic_Lupus_Eryth (Systemic_      disease marked by skin rashes, joint pain and
                                                                      ematosus )            Lupus_Eryt      swelling, inflammation of the kidneys,
                                                                                            hematosus       inflammation of the fibrous tissue surrounding
                                                                                            )               the heart (i.e., the pericardium), as well as
t(1;19)(q23;p13.3)                   C27715                           C27715                  C27715        A chromosomal Not all affected individuals
                                                                                                            other problems. abnormality consisting of the        2011              19
                                                                      (t(1;19)(q23;p13.3))    (t(1;19)(q23 translocation of 19p13.3 with 1q23, resulting in
                                                                                              ;p13.3) )    the fusion of the TCF3 (E2A) gene with the
                                                                                                           PBX1 gene.

t(10;14)(q24;q11)                    C36352                           C36352                  C36352       A chromosomal abnormality consisting of the           2011              25
                                                                      (t(10;14)(q24;q11) )    (t(10;14)(q2 translocation of 10q24 with 14q11, leading to
                                                                                              4;q11) )     inappropriate and abundant expression of
                                                                                                           HOX11 protein in T cells bearing the
                                                                                                           translocation.
t(4;11)(q21;q23)                     C36365                           C36365                  C36365       A chromosomal abnormality consisting of the           2011              20
                                                                      (t(4;11)(q21;q23))      (t(4;11)(q21 translocation of 4q21 with 11q23.
                                                                                              ;q23))



t(5;17)(q32;q12)                     C36362                           C36362                  C36362       A chromosomal abnormality consisting of the           2011              21
                                                                      (t(5;17)(q32;q12) )     (t(5;17)(q32 translocation of 5q32 with 17q12.
                                                                                              ;q12) )



t(8;14)(q24;q11)                     C39347                           C39347                 C39347       A chromosomal abnormality consisting of the            2011              22
                                                                      (t(8;14)(q24;q11) )    (t(8;14)(q24 translocation of 8q24 with 14q11, which
                                                                                             ;q11) )      juxtaposes the c-MYC gene with the gene for
                                                                                                          the T cell receptor alpha chain resulting in
                                                                                                          overexpression of c-MYC in T cells bearing the
t(V;11)(v;q23)                       C38375                           C38375 (t(V;11)(v;q23) C38375       translocation.
                                                                                                          A chromosomal abnormality consisting of the            2011              27
                                                                      )                      (t(V;11)(v;q translocation of genetic material from any one
                                                                                             23) )        of several chromosomes to the 11q23 region,
                                                                                                          resulting in an MLL gene rearrangement.

T-Cell Antigen CD7       CD7, anti    C38935                          C38935 (T-Cell Antigen C38935 (T- Expressed in thymocytes and mature T cells by            2006              79
                         CD7 antibody                                 CD7 )                  Cell Antigen human CD7 Gene (Immunoglobulin
                                                                                             CD7 )        Superfamily), 240-aa 25-kDa (precursor) T-
                                                                                                          Cell Antigen CD7 is a cell surface type I
                                                                                                          transmembrane glycoprotein that interacts with
                                                                                                          SECTM1, contains an Ig-like domain, and is
Concept                          Synonym      CUI      Note                 Concantenation            Concanten Definition                                            Form      Question
                                                                            Values Only               ation                                                                     Number
                                                                                                      Formula


T-Cell Chronic Lymphocytic                    C70649                        C70649 (T-Cell Chronic C70649 (T-
Leukemia                                                                    Lymphocytic Leukemia) Cell Chronic
                                                                                                   Lymphocyti
                                                                                                   c Leukemia)

T-Cell Depletion Therapy         T-Cell       C15699                        C15699 (T-Cell            C15699 (T- NCI-GLOSS|Treatment to destroy T cells,
                                 Depletion                                  Depletion)                Cell       which play an important role in the immune
                                                                                                      Depletion) response. Elimination of T cells from a bone
                                                                                                                 marrow graft from a donor may reduce the
                                                                                                                 chance of an immune reaction against the
T-Cell Differentiation Antigen                C73129   Added to EVS on 18   C73129 (T-Cell                       recipient's tissues.
                                                                                                      C73129 (T- T-cell differentiation antigen CD6 (668 aa, ~72         2006              78
CD6                                                    March 2012           Differentiation Antigen   Cell          kDa) is encoded by the human CD6 gene. This
                                                                            CD6 )                     Differentiati protein plays a role in the adherence of
                                                                                                      on Antigen immature thymus cells to thymic epithelial cells.
                                                                                                      CD6 )
T-Cell Receptor, Alpha-Beta      TCR          C17433                        C17433 (T-Cell         C17433 (T-      T-cell receptors composed of CD3-associated
                                                                            Receptor, Alpha-Beta ) Cell            alpha and beta polypeptide chains and
                                                                                                   Receptor,       expressed primarily in CD4+ or CD8+ T-cells.
                                                                                                   Alpha-Beta      Unlike immunoglobulins, the alpha-beta T-cell
                                                                                                   )               receptors recognize antigens only when
T-Cell Surface Glycoprotein                   C73124   Added to EVS on 18   C73124 (T-Cell                         presented in glycoprotein CD5 (495
                                                                                                      C73124 (T- T-cell surfaceassociation with major aa, ~54            2006              77
CD5                                                    March 2011           Surface Glycoprotein      Cell Surface kDa) is encoded by the human CD5 gene. This
                                                                            CD5 )                     Glycoprotei protein may be involved in regulating the
                                                                                                      n CD5 )      proliferation of T-cells.

T-Cell_Non-                                   C3466                         C3466 (T-Cell_Non- C3466 (T-
Hodgkin_s_Lymphoma                                                          Hodgkin_s_Lymphoma Cell_Non-
                                                                            )                  Hodgkin_s_
                                                                                               Lymphoma
                                                                                               )
Technique                                     C16847                        C16847 (Technique)        C16847      A practiced and regimented skill or series of
                                                                                                      (Technique) actions.




Temporal_Arteritis               Giant Cell   C35065                        C35065                    C35065      A systemic autoimmune vasculitis occurring
                                 Arteritis                                  (Temporal_Arteritis )     (Temporal_ primarily in people over the age of 50.
                                                                                                      Arteritis ) Pathologic features include a necrotizing
                                                                                                                  panarteritis including granulomas and giant
                                                                                                                  cells. There is a predilection for involvement of
Tenderness                                    C75540                        C75540(Tenderness)        C75540      central nervous system blood vessels and the
                                                                                                                  Discomfort elicited through touch or pressure.
                                                                                                      (Tendernes
                                                                                                      s)



Test_Result                                   C36292                        C36292 (Test_Result ) C36292
                                                                                                  (Test_Resul
                                                                                                  t)



thalidomide                                   C1702                         C1702 (thalidomide)       C1702
                                                                                                      (thalidomide
                                                                                                      )



Thaw                                          C48165                        C48165 (Thaw)             C48165         The process whereby heat changes something
                                                                                                      (Thaw)         from a solid to a liquid.




Therapeutic Procedure                         C49236                        C49236 (Therapeutic       C49236
                                                                            Procedure)                (Therapeuti
                                                                                                      c
                                                                                                      Procedure)

Therapy Related Malignant                     C4969                         C4969 (Therapy            C4969      The development of a malignant neoplasm in
Neoplasm                                                                    Related Malignant         (Therapy   response to medical or surgical treatment,
                                                                            Neoplasm )                Related    induced by the treatment itself.
                                                                                                      Malignant
                                                                                                      Neoplasm )
Therapy-Related AML                           C8252                         C8252 (Therapy-           C8252          An acute myeloid leukemia arising as a result
                                                                            Related AML)              (Therapy-      of the mutagenic effect of alkylating agents
                                                                                                      Related        and/or ionizing radiation. (WHO, 2001)
                                                                                                      AML)

Thioguanine                                   C876                          C876 (Thioguanine )       C876        A synthetic guanosine analogue
                                                                                                      (Thioguanin antimetabolite. Phosphorylated by
                                                                                                      e)          hypoxanthine-guanine
                                                                                                                  phosphoribosyltransferase, thioguanine
                                                                                                                  incorporates into DNA and RNA, resulting in
                                                                                                                  inhibition of DNA and RNA syntheses and cell
Concept                         Synonym   CUI      Note   Concantenation           Concanten Definition                                               Form      Question
                                                          Values Only              ation                                                                        Number
                                                                                   Formula


Thrombocytopenic Purpura                  C26870          C26870                   C26870     NCI|Purpura associated with a reduction in                 2900
                                                          (Thrombocytopenic        (Thrombocy circulating blood platelets which can result from
                                                          Purpura)                 topenic    a variety of factors.
                                                                                   Purpura)

Thromboembolism                           C28195          C28195                   C28195    MSH2003_2003_05_12|Obstruction of a                         2900
                                                          (Thromboembolism)        (Thromboe vessel by a blood clot that has been
                                                                                   mbolism)  transported from a distant site by the blood
                                                                                             stream.

Thrombosis                                C26891          C26891 (Thrombosis )     C26891
                                                                                   (Thrombosi
                                                                                   s)



Time                                      C25207          C25207 (Time)            C25207
                                                                                   (Time)




Timepoint                                 C68568          C68568 (Timepoint )      C68568       A specific point in the time continuum,
                                                                                   (Timepoint ) including those established relative to an
                                                                                                event.



Tissue Donor                    Donor     C25168          C25168 (donor)           C25168        Someone who gives blood or tissue or an
                                                                                   (donor)       organ to be used in another person.




T-Lymphocyte                              C12476          C12476 (T-               C12476 (T-
                                                          Lymphocyte)              Lymphocyte
                                                                                   )



T-Lymphocyte                              C12476          C12476 (T-               C12476 (T-
                                                          Lymphocyte)              Lymphocyte
                                                                                   )



Tolerance Induction Pre-Solid             C70612          C70612 (Tolerance        C70612
Organ Transplant                                          Induction Pre-Solid      (Tolerance
                                                          Organ Transplant)        Induction
                                                                                   Pre-Solid
                                                                                   Organ
Topoisomerase I                           C16516          C16516                   Transplant) Encoded by human TOP1 Gene (TOPI
                                                                                   C16516
                                                          (Topoisomerase I)        (Topoisome Family), 765-aa 90.7-kD monomeric DNA
                                                                                   rase I)     Topoisomerase I catalyzes transient ATP-
                                                                                               independent breaking/rejoining of DNA and
                                                                                               controls DNA topology during transcription.
Topoisomerase_II_Inhibitor-               C27755          C27755                   C27755      DNA topoisomerases I and II relax negative
Related_Acute_Myeloid_Leuk                                (Topoisomerase_II_Inhi   (Topoisome
emia                                                      bitor-                   rase_II_Inhi
                                                          Related_Acute_Myeloid    bitor-
                                                          _Leukemia)               Related_Ac
Topoisomerase-II Inhibitor                C1968           C1968                    ute_Myeloid Substances that either stabilize DNA-protein
                                                                                   C1968
                                                          (Topoisomerase-II        (Topoisome complexes damaging DNA (e g., teniposide),
                                                          Inhibitor )              rase-II      or those that inhibit the catalytic activity of the
                                                                                   Inhibitor )  enzyme (e.g., merbarone, ICRF-187). Despite
                                                                                                their differences in action, these agents all
Topotecan Hydrochloride                   C2828           C2828 (Topotecan         C2828        block cells in G2/M
                                                                                                The hydrochloride salt of the semisynthetic
                                                          Hydrochloride )          (Topotecan camptothecin analog topotecan with
                                                                                   Hydrochlori antineoplastic activity. During the S phase of
                                                                                   de )        the cell cycle, topotecan selectively stabilizes
                                                                                               topoisomerase I-DNA covalent complexes,
Total                                     C25304          C25304 (Total)           C25304      thereby inhibiting religation whole, also
                                                                                               Pertaining to an entirety or of topoisomerase I-
                                                                                   (Total)       constituting the full quantity or extent;
                                                                                                 complete; derived by addition.



Total Complement                                          C70611 (Complement (Total                                                                      2400              382
                                                          Hemolytic Activity Complemen
                                                          Assay )            t)



Total Complement Assay                    C70617          C70617 (Total            C70617
                                                          Complement Assay)        (Total
                                                                                   Complemen
                                                                                   t Assay)
Concept                      Synonym     CUI      Note   Concantenation         Concanten Definition                                              Form      Question
                                                         Values Only            ation                                                                       Number
                                                                                Formula


Toxicity                                 C27990          C27990 (Toxicity)      C27990       The finding of bodily harm due to the
                                                                                (Toxicity)   poisonous effects of something.




Toxoplasma                               C75538          C75538(Toxoplasma)     C75538     A genus of protozoa that is parasitic in
                                                                                (Toxoplasm humans, other mammals, and some birds.
                                                                                a)



Transbronchial_Lung_Biopsy               C51749          C51749                C51749                                                                2100
                                                         Transbronchial_Lung_ (Transbronc
                                                         Biopsy                hial_Lung_
                                                                               Biopsy)      NCI|Removal of tissue through the bronchial
                                                                                            wall, for microscopic examination.
Translocation                            C25756          C25756 (Translocation C25756       The movement of a physical object from one
                                                         )                     (Translocati place to another.
                                                                               on )



Translocation 12p                                        C25756 (Translocation              The movement of a physical object from one               2011              29
                                                         ), C13532 (12p)       (Translocati place to another._Proximal (short) arm of
                                                                               on 12p)      chromosome 12



Translocation 9p                                         C25756 (Translocation              The movement of a physical object from one               2011              24
                                                         ), C13563 (9p )       (Translocati place to another._Proximal (short) arm of
                                                                               on 9p)       chromosome 9



Transplant (Graft)           Graft       C12981          C12981 (Graft)         C12981       Healthy skin, bone, or other tissue taken from
                                                                                (Transplant) one part of the body and used to replace
                                                                                             diseased or injured tissue removed from
                                                                                             another part of the body.
Transplantation                          C15342          C15342                 C15342       The replacement of tissue with tissue from the
                                                         (Transplantation )     (Transplant person's own body or from another person.
                                                                                ation )



Treatment Regimen            Treatment   C15697          C15697 (Treatment      C15697     A treatment plan that specifies the dosage, the
                             Protocol                    Regimen )              (Treatment schedule, and the duration of treatment.
                                                                                Regimen )
Trisomy 11                               C37191          C37191 (Trisomy 11)    C37191
                                                                                (Trisomy
                                                                                11)



Trisomy 13                               C36529          C36529 (Trisomy 13)    C36529
                                                                                (Trisomy
                                                                                13)



Trisomy 17                               C37865          C37865 (Trisomy 17 )   C37865      A chromosomal abnormality consisting of the              2011              17
                                                                                (Trisomy 17 presence of a third copy of chromosome 17 in
                                                                                )           somatic cells.



Trisomy 21                               C43224          C43224 (Trisomy 21)    C43224       A chromosomal abnormality consisting of the             2011              18
                                                                                (Trisomy     presence of a third copy of chromosome 21 in
                                                                                21)          somatic cells.



Trisomy 4                                C36530          C36530 (Trisomy 4)     C36530      A chromosomal abnormality consisting of the              2011              16
                                                                                (Trisomy 4) presence of a third copy of chromosome 4 in
                                                                                            somatic cells.



Trisomy 8                                C36396          C36396 (Trisomy 8)     C36396      A chromosomal abnormality consisting of the              2011              15
                                                                                (Trisomy 8) presence of a third copy of chromosome 8 in
                                                                                            somatic cells.



Trypan Blue                              C910            C910 (Trypan Blue )    C910         An acid azo dye commonly used as a stain to
                                                                                (Trypan      distinguish viable from non-viable cells. It turns
                                                                                Blue )       dead cells blue and viable cells unstained. It is
                                                                                             a known animal carcinogen and an
                                                                                             experimental teratogen.
Concept                    Synonym      CUI      Note                   Concantenation         Concanten Definition                                                Form      Question
                                                                        Values Only            ation                                                                         Number
                                                                                               Formula


Trypan Blue                Benzamine    C910                            C910 (Trypan Blue )    C910           An acid azo dye commonly used as a stain to
                           Blue,                                                               (Trypan        distinguish viable from non-viable cells. It turns
                           Visionblue                                                          Blue )         dead cells blue and viable cells unstained. It is
                                                                                                              a known animal carcinogen and an
                                                                                                              experimental teratogen.
Tumor Purging                           C70600                          C70600 (Tumor          C70600
                                                                        Purging)               (Tumor
                                                                                               Purging)



type                                    C25284                          C25284 (type)          C25284
                                                                                               (type)




ulcerative colitis                      C2952                           C2952 (ulcerative      C2952
                                                                        colitis)               (ulcerative
                                                                                               colitis)



Umbilical Cord Blood                    C13300   Use alternate definition C13300 (Umbilical    C13300     Blood from the placenta (afterbirth) that
                                                                          Cord Blood )         (Umbilical contains high concentrations of stem cells
                                                                                               Cord Blood needed to produce new blood cells.
                                                                                               )

Unemployment                            C75563                          C75563(Unemploymen C75563             The state of not having a job.
                                                                        t)                 (Unemploy
                                                                                           ment)



Unique Identifier                       C70663                          C70663 (Unique         C70663         A set of characters used as a code that is
                                                                        Identifier )           (Unique        unique in the context or the system for which it
                                                                                               Identifier )   is created. It serves as a means of
                                                                                                              identification and reference (often instead of a
                                                                                                              name) for an entity, person, thing, function,
Unit                                    C44278                          C44278 (Unit )         C44278         procedure, activity, variable, or body of data.
                                                                                                              A single undivided thing occurring in the
                                                                                               (Unit )        composition of something else.




unit of measure            performance C20641                           C25709 (unit of        C25709         NCI|A measure of how well a patient is able to
                           status                                       measure)               (unit of       perform ordinary tasks and carry out daily
                                                                                               measure)       activities.



Unknown                                 C17998                          C17998 (Unknown)       C17998         NCI|Not known, not observed, not recorded, or
                                                                                               (Unknown)      refused.




unrelated                               C25328                          C25328 (unrelated)     C25328
                                                                                               (unrelated)




Upper_Respiratory_System                C33839                          C33839                C33839
                                                                        (Upper_Respiratory_Sy (Upper_Res
                                                                        stem)                 piratory_Sy
                                                                                              stem)

Valvular Heart Disorder                 C45525                          C45525 (Valvular Heart C45525
                                                                        Disorder)              (Valvular
                                                                                               Heart
                                                                                               Disorder)

Vascular                                C13311                          C13311 (vascular)      C13311         Relating to or containing blood vessels                 2900
                                                                                               (Vascular)




vasculitis                              C26912                          C26912 (vasculitis)    C26912
                                                                                               (vasculitis)




velafermin                              C48425                          C48425 (velafermin)    C48425
                                                                                               (velafermin)
Concept                      Synonym   CUI      Note   Concantenation            Concanten Definition                                          Form      Question
                                                       Values Only               ation                                                                   Number
                                                                                 Formula


Verified                               C45513          C45513 (Verified)         C45513
                                                                                 (Verified)




Very Good Partial Response             C70638          C70638 (Very Good         C70638
(VGPR) of Multiple Myeloma                             Partial Response          (Very Good
or Plasma Cell Leukemia                                (VGPR) of Multiple        Partial
                                                       Myeloma or Plasma         Response
                                                       Cell Leukemia)            (VGPR) of
Viable                                 C25324          C25324 (Viable)           Multiple
                                                                                 C25324     Capable of life or normal growth and
                                                                                 (Viable)   development.




Video-                       VATS      C63704          C63704 VATS,              C63704      NCI|Endoscopic surgery of the pleural cavity         2100              425
assisted_Thoracic_Surgery                                                        (Video-     performed with visualization via video
                                                                                 assisted_Th transmission.
                                                                                 oracic_Surg
                                                                                 ery)
viral                                  C27985          C27985 (viral)            C27985       Having to do with a virus                           2900
                                                                                 (viral)




viral infection                        C3439           C3439 (viral infection)   C3439 (viral NCI|Any disease caused by a virus.                  2900
                                                                                 infection)




Volume                                 C25335          C25335 (Volume )          C25335       The amount of three dimensional space
                                                                                 (Volume )    occupied by an object or the capacity of a
                                                                                              space or container.



whole blood                            C41067          C41067 whole blood        C41067       NCI|Blood that has not been separated into its      2100
                                                                                 (whole       various components; blood that has not been
                                                                                 blood)       modified except for the addition of an
                                                                                              anticoagulant.

without                                C25718          C25718 (without)          C25718
                                                                                 (without)




Yes                                    C49488          C49488 (Yes)              C49488       The affirmative response to a question.
                                                                                 (Yes)




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