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					ECETOC Targeted Risk Assessment - Worker Exposure Estimation - V 2.0
Introduction
Version 2 of the TRA worker tool has been substantially revised. This version 2 predicts worker exposures for the whole range
distinguishing between industrial and professional settings. In addition this initial prediction of exposure can be modified (itera
Modifiers (duration of exposure, physico-chemical properties of a substance, concentration of a substance in a preparation, p
use of Respiratory Protection). The results of the calculations are displayed in either a box report or linear report.
Notes on use
BEFORE STARTING TO USE THIS TOOL, READ THESE NOTES ON USE!!!
Stepwise approach to generate an estimate of worker exposure for a substance.
START: Enter the Substance Specific Data in the input fields (line 7-17). Note that the tool will generate exposure estimations
Reference Values (however input of reference values are needed for the Linear Report!!).
STEP 1. Enter a scenario name and select the appropiate Process Category (PROC) and area of use (Industrial/Professional
STEP 2. Select the relevant conditions for the Exposure Modifyers.
STEP 3. Click on "Generate Report". This will display a box report on the right of the data entry area (green/blue), stating the e
selected and the exposure predictions calculated by the tool. Further iteration on this scenario with the Exposure Scenario Bu
"Generate Report" button will update the box report.
STEP 4. Having finished the iteration on the scenario and to perform a basic risk characterization, click on “Copy Scenario res
report that will be stored under a separate tab (name: substance name + CAS no). NOTE that inclusion of Indicative Referenc
of a proper Linear Report.
By clicking “Clear Scenario”, the information in the Exposure Scenario Builder is cleared, allowing a new exposure scenario to
Clicking “Clear All” will remove all the input parameters for the substance and allows the user to work on a different substance
                                                                            Input parameters

Substance Name

CAS Number

Molecular Weight
Indicative Reference Value (Inhalation)
mg/m3
Basis of the Inhalation Indicative
Reference Value
Indicative Reference Value (Dermal)
mg/kg bw/day
Basis of the Demal Indicative Reference
Value
Likelihood to become Airborne

Is this substance Solid?

Dustiness

Volatility (Pa)

                                                                       Exposure Scenario Builder
Step 1 - Select a REACH Process descriptor

Enter a short scenario name

Select a Process Category (PROC)
Industrial or Public Domain
(Professional) Activity?
Step 2 - Apply Exposure Modifiers (Operational Conditions)
EM1 Ventilation
Does this activity take place indoors or
outdoors?

Is Local Exhaust Ventilation present ?
EM2 Duration of Activity

What is the Duration of the Activity?
EM3 Respiratory Protection
What type of respiratory protection is
used?
EM4 Use in Preparations

Is the substance used in a Preparation?

Select the concentration range (w/w)


                 Clear All                 Clear Scenario
sessment - Worker Exposure Estimation - V 2.0

 tool has been substantially revised. This version 2 predicts worker exposures for the whole range of Process Categories (PROC),
 trial and professional settings. In addition this initial prediction of exposure can be modified (iterated on) for a limited set of Exposure
ure, physico-chemical properties of a substance, concentration of a substance in a preparation, presence of Local Extract Ventilation,
n). The results of the calculations are displayed in either a box report or linear report.

SE THIS TOOL, READ THESE NOTES ON USE!!!
ate an estimate of worker exposure for a substance.
e Specific Data in the input fields (line 7-17). Note that the tool will generate exposure estimations without the input of Indicative
 input of reference values are needed for the Linear Report!!).
 me and select the appropiate Process Category (PROC) and area of use (Industrial/Professional) in the Exposure Scenario Builder.
 conditions for the Exposure Modifyers.
 Report". This will display a box report on the right of the data entry area (green/blue), stating the exposure scenario with the conditions
 redictions calculated by the tool. Further iteration on this scenario with the Exposure Scenario Builder is possible; by clicking again the
 l update the box report.
  iteration on the scenario and to perform a basic risk characterization, click on “Copy Scenario results to the Linear Report” to generate a
 er a separate tab (name: substance name + CAS no). NOTE that inclusion of Indicative Reference Values is needed for the generation

 the information in the Exposure Scenario Builder is cleared, allowing a new exposure scenario to be built for the same substance.
ve all the input parameters for the substance and allows the user to work on a different substance.
                                                  Input parameters
                  Phynylmercury acetate

                  62-38-4

                  336,75




 rne
                  No


                  0.0007999342105263


                                             Exposure Scenario Builder
 cess descriptor
                  Mixing and blending
              a
                  5 -Mixing or blending in batch processes (multistage and/or significant contact)
              5 -Mixing or blending in batch processes (multistage and/or significant contact)



odifiers (Operational Conditions)




                                                                           Only relevant if "Indoors" is chosen above


               < 15 mins


              Respiratory protection is not used



               Yes


                     <1%
                                                                  Only relevant if the substance is used in a Preparation


                 Clear Scenario                Generate Report                Copy Scenario results to the Linear Report
gories (PROC),
 d set of Exposure
Extract Ventilation,




of Indicative

Scenario Builder.

 with the conditions
by clicking again the

Report” to generate a
d for the generation

 me substance.
Worker Exposure report for Substance Phynylmercury acetate (CAS NO. 62-38-4) - Version 2.0




High fugacity
Exposure scenario (Mixing and blending)

Process Category 5 -Mixing or blending in batch processes (multistage and/or significant contact).

Industrial activity

Initial Exposure Estimate

Exposure modifiers

The activity takes place Indoors

Ventilation is not present

The maximum duration of the activity is < 15 mins
Respiratory protection is not used

Is this substance part of a preparation? Yes at < 1 %                      w/w

Assessment factor applied is 0,1

The Inhalative Exposure Estimate for this Exposure Scenario is

Dermal exposures may arise from this Exposure Scenario and assuming a maximal exposed skin area

                                                                                          are estimated at
  Exposure Estimate (Units ppm)




                             250




                             250

                              25
                              25



2,5

                         2,5 ppm

                      480 (sq cm)

               13,7143 mg/kg/day
Worker
Consumer


No
Yes


Low
Medium
High


Occupational Exposure Limit
Other regulatory Limit
Experimental result -NO[A]EL
DNEL
Vapour pressure (kPa)            Dustiness                 Fugacity

>=0.00001- <0.5                  Low                       Low
0.5 to 10                        Medium                    Medium
>10                              High                      High




Help on fugacity selction criteria

General description              Relative dustiness        Typical materials               TRA Selection Value
                                 potential
Not dusty                        1                                          a
                                                           Plastic granules ,
                                                           pelleted fertilisers                      Low
Slightly dusty                   10 - 100 times dustier    Dry garden peat, sugar,
                                                           salt

Dusty                            100 -      1,000   times Talc, graphite
                                 dustier
                                                                                                   Medium
Very/extremely dusty             More than 1,000 times Cement dust, milled                           High
                                 dustier               powders, plaster, flour,
                                                       lyophilised powders,
                                                       (process fumes b)

a
 Exposures to materials where a substance is contained and bound in a matrix (e.g. pigment within a plastic, filler
within paint) should also be included in this category. Although the real exposure is actually determined by a
combination of physical form and the bioavailability of the substance within the matrix, because the bioavailability is
very low under such circumstances, then this will result in a low exposure potential.


b
  Process fumes (e.g. rubber, welding, soldering) behave like gases and would be considered within this category if
exposures to such complex mixtures are considered in any risk assessment.
PORC 22-25 (Metals) only - Fugacity classifications for process temperature / melting point
Process temperature* in relation to
           melting point
   process temp < melting point
   process temp ≈ melting point
   process temp > melting point
* In drilling or “abrasion” techniques (e.g. grinding) the temperature of the “tool-material contact area” may be used
                                           instead of the process temperature.
als) only - Fugacity classifications for process temperature / melting point
                                                Fugacity

                                                         low
                                                       moderate
                                                         high
n” techniques (e.g. grinding) the temperature of the “tool-material contact area” may be used
                  instead of the process temperature.
nale Behind TRA Worker v2 Exposure Predictions


                                                                                              Industrial   Professional     EASE LEV          EASE LEV
                                                               Predicted EASE TR93 exposure   exposure      exposure      Effectiveness     Effectiveness
                  Exposure scenario          LEV   Fugacity   Exposure (95th%)  prediction    prediction    prediction    Industrial (%)   Professional (%)

    Use in closed process, no likelihood of
    exposure                                yes      High            1             0.01                                        N/a               N/a
    (solids)                                no                       1             0.01          0.01          0.1
    mg/m3                                   yes                      1             0.01                                        N/a               N/a
                                                   Moderate
                                            no                       1             0.01          0.01          0.01
                                            yes                     0.1            0.01                                        N/a               N/a
                                                     Low
                                            no                      0.1            0.01          0.01          0.01

    (volatiles)                            yes                      0.1            0.01                                        N/a               N/a
                                                     High
    ppm                                    no                       0.1            0.01          0.01          0.1
                                           yes                      0.1            0.01                                        N/a               N/a
                                                   Moderate
                                           no                       0.1            0.01          0.01          0.01
                                           yes                      0.1            0.01                                        N/a               N/a
                                                     Low
                                           no                       0.1            0.01          0.01          0.01

    Use in closed, continuous process
    with occasional controlled exposure    yes       High           1               1                                          90                80
    (solids)                               no                       5               5             1             5

    mg/m3                                  yes     Moderate         1              0.1                                         90                80
                                           no                       5              0.5           0.5            1
                                           yes                     0.01            0.01                                        90                80
                                                     Low
                                           no                      0.01            0.01          0.01          0.01


    (volatiles)                            yes                     200             20                                          90                80
                                                     High
    ppm                                    no                      500             50            50            50
                                           yes                      50              5                                          90                80
                                                   Moderate
                                           no                      100             10            10            20
                                           yes                      3              0.5                                         90                80
                                                     Low
                                           no                       10              1             1             5

    Use in closed batch process (synthesis
                                                     High
    or formulation)                        yes                      1              0.1                                         90                80
    (solids)                               no                       5               1             1             5
    mg/m3                                  yes                       1             0.1                                         90                80
                                                   Moderate
                                           no                        5              1             1             1
                                           yes                      0.1            0.01                                        90                80
                                                     Low
                                           no                       0.1            0.1           0.1           0.1

    (volatiles)                            yes                      0.1            20                                          90                80
                                                     High
    ppm                                    no                      200             100           100           100
                                           yes                      0.1             5                                          90                80
                                                   Moderate
                                           no                       50             25            25            25
                                           yes                      0.1            0.1                                         90                80
                                                     Low
                                           no                       3               3             3             3



    Use in batch and other process
    (synthesis) where opportunity for                High
    exposure arises                        yes                      5               5                                          90                80
    (solids)                               no                       50             25            25            50
    mg/m3                                  yes                      0.5            0.5                                         90                80
                                                   Moderate
                                           no                       5               5             5             5
                                           yes                      0.1            0.1                                         90                80
                                                     Low
                                           no                       0.1            0.5           0.5            1

    (volatiles)                            yes                     200             100                                         90                80
                                                     High
    ppm                                    no                      500             250           100           250
                                           yes                      50             25                                          90                80
                                                   Moderate
                                           no                      100             100           20            50
                                           yes                      3               1                                          90                80
                                                     Low
                                           no                       10             10             5            10



                                                     High
    Mixing or blending in batch processes
    (multistage and/or significant contact) yes                     5               5                                          90                80
    (solids)                               no                       50             50            25            50
nale Behind TRA Worker v2 Exposure Predictions


                                                                                               Industrial   Professional     EASE LEV          EASE LEV
                                                                Predicted EASE TR93 exposure   exposure      exposure      Effectiveness     Effectiveness
                  Exposure scenario           LEV   Fugacity   Exposure (95th%)  prediction    prediction    prediction    Industrial (%)   Professional (%)
    mg/m3                                   yes                       0.5           0.5                                          90                80
                                                    Moderate
                                            no                       5               5             5             5
                                            yes                      0.1            0.1                                         90                80
                                                      Low
                                            no                       0.1             1            0.5            1

    (volatiles)                             yes       High          200             100                                         90                80
    ppm                                     no                      500             500           250           500
                                            yes     Moderate         50             20                                          90                80
                                            no                      100             100           50            100
                                            yes       Low            3               3                                          90                80
                                            no                       10             10             5            10




                                                      High
    Calendering operations                  yes                      5                                                          90                80
    (solids)                                no                       50                           25            50
    mg/m3                                   yes                      0.5                                                        90                80
                                                    Moderate
                                            no                       5                             5             5
                                            yes                      0.1                                                        90                80
                                                      Low
                                            no                       0.1                          0.1            1

    (volatiles)                             yes                     200                                                         90                80
                                                      High
    ppm                                     no                      500                           250           500
                                            yes                      50                                                         90                80
                                                    Moderate
                                            no                      100                           50            100
                                            yes                      3                                                          90                80
                                                      Low
                                            no                       10                            5            10

    Industrial spraying                     yes       High           10             10                                          95                n/a
    (solids)                                no                      200             200           100           n/a
    mg/m3                                   yes                      1               1                                          95                n/a
                                                    Moderate
                                            no                       20             20            20            n/a
                                            yes                      0.1            0.1                                         95                n/a
                                                      Low
                                            no                       1               1             1            n/a

    (volatiles)                             yes                     500             100                                         95                n/a
                                                      High
    ppm                                     no                      1000           1000           500           n/a
                                            yes                     200             50                                          95                n/a
                                                    Moderate
                                            no                      500             500           250           n/a
                                            yes                     200             20                                          95                n/a
                                                      Low
                                            no                      500             100           100           n/a

    Transfer of chemicals from/to
    vessels/large containers at non                   High
    dedicated facilities                    yes                      5               5                                          90                80
    (solids)                                no                       50             50            50            50
    mg/m3                                   yes                      0.5            0.5                                         90                80
                                                    Moderate
                                            no                       5               5             5             5
                                            yes                      0.1            0.1                                         90                80
                                                      Low
                                            no                       0.1            0.5           0.5           0.5

    (volatiles)                             yes                     200             100                                         90                80
                                                      High
    ppm                                     no                      500             250           250           500
                                            yes                      50             25                                          90                80
                                                    Moderate
                                            no                      100             50            50            100
                                            yes                      3               3                                          90                80
                                                      Low
                                            no                       10             10            10            25

    Transfer of chemicals from/to
    vessels/large containers at dedicated             High
    facilities                              yes                      5               5                                          95                80
    (solids)                                no                       50             50            25            50
    mg/m3                                   yes                      0.5            0.5                                         95                80
                                                    Moderate
                                            no                       5               5             5             5
                                            yes                      0.1            0.1                                         95                80
                                                      Low
                                            no                       0.1            0.5           0.1           0.5
nale Behind TRA Worker v2 Exposure Predictions


                                                                                             Industrial   Professional     EASE LEV          EASE LEV
                                                              Predicted EASE TR93 exposure   exposure      exposure      Effectiveness     Effectiveness
                  Exposure scenario         LEV   Fugacity   Exposure (95th%)  prediction    prediction    prediction    Industrial (%)   Professional (%)

    (volatiles)                            yes                    200             100                                         97                90
                                                    High
    ppm                                    no                     500             250           150           250
                                           yes                     50             25                                          97                90
                                                  Moderate
                                           no                     100             50            50            50
                                           yes                     3               3                                          97                90
                                                    Low
                                           no                      10             10             5            10

    Transfer of chemicals into small
                                                    High
    containers (dedicated filling line)    yes                     5               1                                          90                80
    (solids)                               no                      50             20            20            20
    mg/m3                                  yes                     0.5            0.5                                         90                80
                                                  Moderate
                                           no                       5              5             5             5
                                           yes                     0.1            0.1                                         90                80
                                                    Low
                                           no                      0.1            0.5           0.1           0.5

    (volatiles)                            yes                    200             50                                          90                80
                                                    High
    ppm                                    no                     500             250           200           250
                                           yes                     50             13                                          90                80
                                                  Moderate
                                           no                     100             100           50            100
                                           yes                     3               1                                          90                80
                                                    Low
                                           no                      10             10             5            10

    Roller application or brushing         yes      High           5               1                                          90                80
    (solids)                               no                      50             10            10            10
    mg/m3                                  yes                     0.5            0.5                                         90                80
                                                  Moderate
                                           no                      5               5             5             5
                                           yes                     0.1            0.1                                         90                80
                                                    Low
                                           no                      0.1            0.5           0.5           0.5

    (volatiles)                            yes                    500             100                                         90                80
                                                    High
    ppm                                    no                     500             500           250           500
                                           yes                    100             20                                          90                80
                                                  Moderate
                                           no                     500             100           50            100
                                           yes                     50             10                                          90                80
                                                    Low
                                           no                     500             100           10            25

    Non-industrial spraying                yes      High           10             10                                          n/a               80
    (solids)                               no                     200             200           n/a           200
    mg/m3                                  yes                     1               1                                          n/a               80
                                                  Moderate
                                           no                      20             20            n/a           20
                                           yes                     0.1            0.1                                         n/a               80
                                                    Low
                                           no                      1               1            n/a            1

    (volatiles)                            yes                    500             100                                         n/a               80
                                                    High
    ppm                                    no                     1000           1000           n/a          1000
                                           yes                    200             50                                          n/a               80
                                                  Moderate
                                           no                     500             500           n/a           500
                                           yes                    200             20                                          n/a               80
                                                    Low
                                           no                     500             100           n/a           100

    Use as a blowing agent                 yes      High           N/a            N/a                                         N/a               N/a
    (solids)                               no                      N/a            N/a           N/a           N/a
    mg/m3                                  yes                     N/a            N/a                                         N/a               N/a
                                                  Moderate
                                           no                      N/a            N/a           N/a           N/a
                                           yes                     N/a            N/a                                         N/a               N/a
                                                    Low
                                           no                      N/a            N/a           N/a           N/a

    (volatiles)                            yes                    200             40                                          80                80
                                                    High
    ppm                                    no                     500             100           100           500
                                           yes                     50             10                                          80                80
                                                  Moderate
                                           no                     100             20            20            100
                                           yes                     3              0.5                                         80                80
                                                    Low
                                           no                      10              2             2            10

    Treatment of articles by dipping and
                                                    High
    pouring                                yes                     1               1                                          90                80
nale Behind TRA Worker v2 Exposure Predictions


                                                                                               Industrial   Professional     EASE LEV          EASE LEV
                                                                Predicted EASE TR93 exposure   exposure      exposure      Effectiveness     Effectiveness
                  Exposure scenario           LEV   Fugacity   Exposure (95th%)  prediction    prediction    prediction    Industrial (%)   Professional (%)
    (solids)                                 no                      5               5             5             5
    mg/m3                                    yes                     1               1                                          90                80
                                                    Moderate
                                             no                       5              5             1             5
                                             yes                     0.1            0.1                                         90                80
                                                      Low
                                             no                      0.1            0.5           0.1           0.5

    (volatiles)                              yes                    200             200                                         90                80
                                                      High
    ppm                                      no                     500             500           250           250
                                             yes                     50             50                                          90                80
                                                    Moderate
                                             no                     100             100           50            100
                                             yes                     3               3                                          90                80
                                                      Low
                                             no                      10             10            10            10



    Production of preparations or articles
                                                      High
    by tabletting, compression, extrusion,
    pelletisation                            yes                     5               5                                          90                80
    (solids)                                 no                      50             50            10            50
    mg/m3                                    yes                     0.5            0.5                                         90                80
                                                    Moderate
                                             no                       5              5             1             5
                                             yes                     0.1            0.1                                         90                80
                                                      Low
                                             no                      0.1             1            0.1            1

    (volatiles)                              yes                    200             100                                         90                80
                                                      High
    ppm                                      no                     500             500           250           500
                                             yes                     50             25                                          90                80
                                                    Moderate
                                             no                     100             100           50            100
                                             yes                     3               3                                          90                80
                                                      Low
                                             no                      10             10             5            10

    Use of laboratory reagents in small
                                                      High
    scale laboratories                       yes                     1              0.5                                         90                80
    (solids)                                 no                      5               5             5             5
    mg/m3                                    yes                     1              0.1                                         90                80
                                                    Moderate
                                             no                      5              0.5           0.5           0.5
                                             yes                     0.1            0.01                                        90                80
                                                      Low
                                             no                      0.1            0.1           0.1           0.1

    (volatiles)                              yes                    200             10                                          90                80
                                                      High
    ppm                                      no                     500             50            50            50
                                             yes                     50              1                                          90                80
                                                    Moderate
                                             no                     100             10            10            10
                                             yes                     3              0.1                                         90                80
                                                      Low
                                             no                      10              5             5             5

    Using material as fuel sources (limited
    exposure to unburned product to be                High
    expected)                               yes                      5               5                                          90                80
    (solids)                                 no                      50             50            10            50
    mg/m3                                    yes                     5               5                                          90                80
                                                    Moderate
                                             no                      50             50             5            20
                                             yes                     0.1             1                                          90                80
                                                      Low
                                             no                      0.1             5            0.1            5

    (volatiles)                              yes                    200             20                                          90                80
                                                      High
    ppm                                      no                     500             50            25            50
                                             yes                     50              5                                          90                80
                                                    Moderate
                                             no                     100             10             5            10
                                             yes                     3              0.1                                         90                80
                                                      Low
                                             no                      10              1             1             1



    Lubrication at high energy conditions             High
    and in partly open process               yes                     10             10                                          95                90
    (solids)                                 no                     200             200           50            200
    mg/m3                                    yes                     10              5                                          95                90
                                                    Moderate
                                             no                     200             50            20            50
                                             yes                     0.1             1                                          95                90
                                                      Low
nale Behind TRA Worker v2 Exposure Predictions


                                                                                             Industrial   Professional     EASE LEV          EASE LEV
                                                              Predicted EASE TR93 exposure   exposure      exposure      Effectiveness     Effectiveness
                  Exposure scenario         LEV   Fugacity   Exposure (95th%)  prediction    prediction    prediction    Industrial (%)   Professional (%)
                                                    Low
                                           no                      0.1            10             1            10

    (volatiles)                            yes                    200             200                                         95                90
                                                    High
    ppm                                    no                     500             500           100           500
                                           yes                    200             100                                         95                90
                                                  Moderate
                                           no                     500             500           50            200
                                           yes                    200             50                                          95                90
                                                    Low
                                           no                     500             100           20            50


                                                    High
    Greasing at high energy conditions     yes                     10                                                         95                90
    (solids)                               no                     200                           50            200
    mg/m3                                  yes                     10                                                         95                90
                                                  Moderate
                                           no                     200                           20            50
                                           yes                     0.1                                                        95                90
                                                    Low
                                           no                      0.1                           1             5

    (volatiles)                            yes                    200                                                         95                90
                                                    High
    ppm                                    no                     500                           100           500
                                           yes                    200                                                         95                90
                                                  Moderate
                                           no                     500                           50            200
                                           yes                    200                                                         95                90
                                                    Low
                                           no                     500                           20            50

    Hand-mixing with intimate contact
                                                    High
    (only PPE available)                   yes                     5                                                          90                80
    (solids)                               no                      50                           25            50
    mg/m3                                  yes                     0.5                                                        90                80
                                                  Moderate
                                           no                      5                             5             5
                                           yes                     0.1                                                        90                80
                                                    Low
                                           no                      0.1                          0.5           0.5

    (volatiles)                            yes                    500                                                         90                80
                                                    High
    ppm                                    no                     500                           250           500
                                           yes                    100                                                         90                80
                                                  Moderate
                                           no                     500                           50            100
                                           yes                     50                                                         90                80
                                                    Low
                                           no                     500                           10            25

    Heat and pressure transfer fluids
    (closed systems) in dispersive use     yes      High           1                                                          n/a               80
    (solids)                               no                      5                            n/a            5

    mg/m3                                  yes    Moderate         1                                                          n/a               80
                                           no                      5                            n/a            1
                                           yes                    0.01                                                        n/a               80
                                                    Low
                                           no                     0.01                          n/a           0.01


    (volatiles)                            yes      High          200                                                         n/a               80
    ppm                                    no                     500                           n/a           50
                                           yes                     50                                                         n/a               80
                                                  Moderate
                                           no                     100                           n/a           20
                                           yes                     3                                                          n/a               80
                                                    Low
                                           no                      10                           n/a            5

    Low energy manipulation of
    substances bound in materials and/or            High
    articles                               yes                                                                                90                80
    (solids)                               no                                      1            10            20
    mg/m3                                  yes                                                                                90                80
                                                  Moderate
                                           no                                     0.5            3             5
                                           yes                                                                                90                80
                                                    Low
                                           no                                     0.2            1             3

    (volatiles)                            yes                                                                                n/a               n/a
                                                    High
    ppm                                    no                                                   n/a           n/a
                                           yes                                                                                n/a               n/a
                                                  Moderate
                                           no                                                   n/a           n/a
nale Behind TRA Worker v2 Exposure Predictions


                                                                                             Industrial   Professional     EASE LEV          EASE LEV
                                                              Predicted EASE TR93 exposure   exposure      exposure      Effectiveness     Effectiveness
                  Exposure scenario         LEV   Fugacity   Exposure (95th%)  prediction    prediction    prediction    Industrial (%)   Professional (%)
                                           yes                                                                                n/a               n/a
                                                    Low
                                           no                                                   n/a           n/a



    Potentially closed operations with              High
    minerals at elevated temperature       yes                                                                                90                n/a
    (solids)                               no                                      3            10            n/a
    mg/m3                                  yes                                                                                90                n/a
                                                  Moderate
                                           no                                     1.6            3            n/a
                                           yes                                                                                90                n/a
                                                    Low
                                           no                                     n/a            1            n/a

    (volatiles)                            yes                                                                                n/a               n/a
                                                    High
    ppm                                    no                                                   n/a           n/a
                                           yes                                                                                n/a               n/a
                                                  Moderate
                                           no                                                   n/a           n/a
                                           yes                                                                                n/a               n/a
                                                    Low
                                           no                                                   n/a           n/a



    Open processing and transfer of                 High
    minerals at elevated temperature       yes                     5                                                          90                80
    (solids)                               no                      50             1.6           10            20
    mg/m3                                  yes                     0.5                                                        90                80
                                                  Moderate
                                           no                      5              1.6            3             5
                                           yes                     0.1                                                        90                80
                                                    Low
                                           no                      0.1            n/a            1             3

    (volatiles)                            yes                    200                                                         N/a               N/a
                                                    High
    ppm                                    no                     500                           N/a           N/a
                                           yes                     50                                                         N/a               N/a
                                                  Moderate
                                           no                     100                           N/a           N/a
                                           yes      Low            3                                                          N/a               N/a
                                           no                      10                           N/a           N/a

    High (mechanical) energy work-up of
    substances bound in materials and/or            High
    articles                               yes                                                                                80                75
    (solids)                               no                                     1.6           10            20
    mg/m3                                  yes                                                                                80                75
                                                  Moderate
                                           no                                     0.5            3             5
                                           yes                                                                                80                75
                                                    Low
                                           no                                     0.5            1             3

    (volatiles)                            yes                                                                                n/a               n/a
                                                    High
    ppm                                    no                                                   n/a           n/a
                                           yes                                                                                n/a               n/a
                                                  Moderate
                                           no                                                   n/a           n/a
                                           yes                                                                                n/a               n/a
                                                    Low
                                           no                                                   n/a           n/a

    Hot work operations with metals        yes      High                                                                      90                80
    (solids)                               no                                      1             5            10
    mg/m3                                  yes                                                                                90                80
                                                  Moderate
                                           no                                      1             5            10
                                           yes                                                                                90                80
                                                    Low
                                           no                                      1             5            10

    (volatiles)                            yes                                                                                N/a               N/a
                                                    High
    ppm                                    no                                                   N/a           N/a
                                           yes                                                                                N/a               N/a
                                                  Moderate
                                           no                                                   N/a           N/a
                                           yes                                                                                N/a               N/a
                                                    Low
                                           no                                                   N/a           N/a
          REACH Process Categories
PROC 1
PROC 2
PROC 3
PROC 4
PROC 5
PROC 6
PROC 7
PROC 8a
PROC 8b
PROC 9
PROC 10
PROC 11
PROC 12
PROC 13
PROC 14
PROC 15
PROC 16
PROC 17
PROC 18
PROC 19
PROC 20
PROC 21
PROC 22



PROC 23



PROC 24



PROC 25
                                      REACH Process Categories
1 - Use in closed process, no likelihood of exposure
2 - Use in closed, continuous process with occasional controlled exposure
3 - Use in closed batch process (synthesis or formulation)
4 - Use in batch and other process (synthesis) where opportunity for exposure arises
5 -Mixing or blending in batch processes (multistage and/or significant contact)
6 -Calendering operations
7 -Industrial spraying
8a -Transfer of chemicals from/to vessels/ large containers at non dedicated facilities
8b -Transfer of chemicals from/to vessels/ large containers at dedicated facilities
9 -Transfer of chemicals into small containers (dedicated filling line)
10 - Roller application or brushing
11 - Non industrial spraying
12 - Use of blow agents for foam production
13 -Treatment of articles by dipping and pouring
14 - Production of preparations or articles by tabletting, compression, extrusion, pelletisation
15 - Use of laboratory reagents in small scale laboratories
16 - Using material as fuel sources, limited exposure to unburned product to be expected
17 - Lubrication at high energy conditions and in partly open process
18 - Greasing at high energy conditions
19 - Hand-mixing with intimate contact (only PPE available
20 - Heat and pressure transfer fluids (closed systems) in dispersive use
21 - Low energy manipulation of substances bound in materials and/or articles
22a - Potentially closed operations with minerals at elevated temperature - pt<mp - Low Fugacity
22b - Potentially closed operations with minerals at elevated temperature - pt ≈ mp - Med Fugacity
22c - Potentially closed operations with minerals at elevated temperature - pt > mp - High Fugacity
23a - Open processing and transfer of minerals at elevated temperature - pt<mp - Low Fugacity
23b - Open processing and transfer of minerals at elevated temperature - pt ≈ mp - Med Fugacity
23c - Open processing and transfer of minerals at elevated temperature - pt > mp - High Fugacity
24a - High (mechanical) energy work-up of substances bound in materials and/or articles - pt<mp - Low Fugacity
24b - High (mechanical) energy work-up of substances bound in materials and/or articles - pt ≈ mp - Med Fugacity
24c - High (mechanical) energy work-up of substances bound in materials and/or articles - pt > mp - High Fugacity
25a - Hot work operations with metals - pt<mp - Low Fugacity
25b - Hot work operations with metals - pt ≈ mp - Med Fugacity
25c - Hot work operations with metals - pt > mp - High Fugacity
Duration of activity   Exposure modifying factor
>4 hours (default)     1
1 - 4 hours            0.6
15 mins - 1 hour       0.2
< 15 mins              0.1
                                                                               Exposure reduction
                  RPE Description / standard phrase                 APF              factor


Respiratory protection is not used                                  n/a                             1
Repiratory protection capable offering a 90% reduction in inhaled
concentrations of the substance                                           10                   0.1
Repiratory protection capable offering a 95% reduction in inhaled
concentrations of the substance                                           20                  0.05
              Comments

                  n/a


refer to COSHH Essentials Sheet R2


refer to COSHH Essentials Sheet R3
    Concentration in mixture (w/w)      Exposure modifying factor
           Not in a mixture                         1
                > 25%                               1               *
               5 – 25%                             0.6
                1 – 5%                             0.2
                 <1%                               0.1

* Highest concentration in 1999/45/EE the EU Dangerous
Preparations Directive
       Generic Exposure Scenarios for Tier 1 Assessment
                                                                                       Significant                                                 Predicted
                                                                                         Dermal                   Predicted EASE                    dermal
                                                                                       Exposure                   dermal exposure Exposed skin     exposure
                                                                                         Likely?     LEV present?   (ug/cm2/day)  surface (cm2)   (mg/kg/day)                                       Comments
PROC   Wide Dispersive Uses
  1    Use in closed process, no likelihood of exposure                                   Yes            Yes             10                          0.03
                                                                                                                                                                PROC expected to have minimal exposure are assigned predicted exposures
                                                                                                         No             100            240           0.34       consistent with Riskofderm and other comparable source data. One hand face only
                                                                                                                                                                EASE predicts very low (non-dispersive, non- direct handling).0.1g/cm2 a realistic
 2     Use in closed, continuous process with occasional controlled exposure              Yes            Yes             20                          0.14       worst case. 2 hands face only
                                                                                                                                                                EASE predicts (signif breaching, direct handling, intermittent exposure). Assumes 2
                                                                                                         No             200            480           1.37       hands face only

 3     Use in closed batch process (synthesis or formulation)                             Yes            Yes             10                          0.03
                                                                                                                                                                PROC expected to have minimal exposure are assigned predicted exposures
                                                                                                         No             100            240           0.34       consistent with Riskofderm and other comparable source data. One hand face only

 4     Use in batch and other process (synthesis) where opportunity for exposure
                                                                                                                                                                EASE predicts very low (non-dispersive, non- direct handling).0.1g/cm2 a realistic
       arises
                                                                                          Yes            Yes            100                          0.69       worst case. 2 hands face only
                                                                                                                                                                EASE predicts (signif breaching, direct handling, intermittent exposure). Assumes 2
                                                                                                         No            1000            480           6.86       hands face only

 5     Mixing or blending in batch processes (multistage and/or significant
       contact)
                                                                                          Yes           Yes             10                          0.07         EASE predicts very low. Assumes 2 hands face only,
                                                                                                                                                                EASE predicts 5g/cm2(wide-dispersive, mobile dust, direct handling,
                                                                                                         No            2000            480          13.71       intermittent).2g/cm2 a more realistic worst case. 2 hands face only,
                                                                                                                                                                EASE predicts (wide-dispersive, mobile dust, no direct handling) very low. Assumes 2
 6     Calendering operations                                                             Yes           Yes            100                          1.37        hands face only,
                                                                                                                                                                EASE predicts 5g/cm2(wide-dispersive, mobile dust, direct handling,
                                                                                                         No            2000            960          27.43       intermittent).2g/cm2 a more realistic worst case. 2 hands face only,
                                                                                                                                                                EASE predicts 0.1 (wide-dispersive, mobile dust, direct handling, incidental). Assumes
 7     Industrial spraying                                                                Yes           Yes            100                          2.14        2 hands and forearms
                                                                                                                                                                EASE predicts (wide-dispersive, mobile dust, no direct handling) very low. Assumes 2
                                                                                                         No            2000           1500          42.86       hands and forearms

 8a    Transfer of chemicals from/to vessels/ large containers at non dedicated
                                                                                                                                                                EASE predicts (wide dispersive, direct handling, intermittent exposure). Assumes 2
       facilities
                                                                                          Yes            Yes            10                          0.14        hands
                                                                                                                                                                                      2
                                                                                                                                                                EASE predicts 5g/cm (wide dispersive, direct handling, intermittent exposure). 1g/cm2
                                                                                                         No            1000            960          13.71       a more realistic worst case. 2 hands

 8b    Transfer of chemicals from/to vessels/ large containers at dedicated
                                                                                                                                                                EASE predicts (wide dispersive, direct handling, intermittent exposure). Assumes 2
       facilities                                                                         Yes           Yes            100                          0.69        hands
                                                                                                                                                                EASE predicts 5g/cm 2 (wide dispersive, direct handling, intermittent exposure). 2g/cm2
                                                                                                         No            1000            480          6.86        a more realistic worst case. 2 hands
                                                                                                                                                                EASE predicts very low (non-dispersive, non- direct handling).0.1g/cm2 a realistic
 9     Transfer of chemicals into small containers (dedicated filling line)               Yes           Yes            100                          0.69        worst case. 2 hands face only
                                                                                                                                                                EASE predicts (signif breaching, direct handling, intermittent exposure). Assumes 2
                                                                                                         No            1000            480          6.86        hands face only
                                                                                                                                                                EASE predicts (wide dispersive, mobile dust, direct handling, incidental). Assumes 2
 10    Roller application or brushing                                                     Yes           Yes            100                          1.37        hands
                                                                                                                                                                EASE predicts 5g/cm2 (wide dispersive, mobile dust, direct handling, intermittent).
                                                                                                         No            2000            960          27.43       2g/cm2 a more realistic worst case. 2 hands
                                                                                                                                                                EASE predicts (wide-dispersive, mobile dust, direct handling, incidental). Assumes 2
 11    Non industrial spraying                                                            Yes           Yes            100                          2.14        hands and forearms
                                                                                                                                                                EASE predicts 5g/cm2 (wide dispersive, mobile dust, direct handling, intermittent).
                                                                                                         No            5000           1500         107.14       Assumes 2 hands and forearms

 12    Use of blowing agents for foam production                                          Yes           Yes             10                          0.03
                                                                                                                                                                PROC expected to have minimal exposure are assigned predicted exposures
                                                                                                         No            100             240          0.34        consistent with Riskofderm and other comparable source data. One hand face only
                                                                                                                                                                EASE predicts very low (wide-dispersive, mobile dust, no direct handling) 0.1g/cm2 a
 13    Treatment of articles by dipping and pouring                                       Yes           Yes            100                          0.69        realistic worst case.2 hands face only,
                                                                                                                                                                EASE predicts 5g/cm2 (wide-dispersive, mobile dust, direct handling,
                                                                                                         No            2000            480          13.71       intermittent).2g/cm2 a more realistic worst case. 2 hands face only,
                                                                                                                                                                EASE predicts very low (non-dispersive, non- direct handling).0.1g/cm2 a realistic
 14    Production of preparations or articles by tabletting, compression, extrusion,      Yes           Yes             50                          0.34        worst case. 2 hands face only
                                                                                                                                                                EASE predicts (signif breaching, direct handling, intermittent exposure). Assumes 2
       pelletisation
                                                                                                         No            500             480          3.43        hands face only

 15    Use of laboratory reagents in small scale laboratories                             Yes           Yes             10                          0.03
                                                                                                                                                                PROC expected to have minimal exposure are assigned predicted exposures
                                                                                                         No            100             240          0.34        consistent with Riskofderm and other comparable source data. One hand face only

 16    Using material as fuel sources, limited exposure to unburned product to be         Yes           Yes             10                          0.03
       expected                                                                                                                                                 PROC expected to have minimal exposure are assigned predicted exposures
                                                                                                         No            100             240          0.34        consistent with Riskofderm and other comparable source data. One hand face only
                                                                                                                                                                EASE predicts (dispersive, mobile dust, direct handling, incidental contact). Assumes 2
 17    Lubrication at high energy conditions and in partly open process                   Yes           Yes            100                          1.37        hands
                                                                                                                                                                EASE predicts (dispersive, mobile dust, direct handling, intermittent contact). Assumes
                                                                                                         No            2000            960          27.43       2 hands
                                                                              Significant                                                 Predicted
                                                                                Dermal                   Predicted EASE                    dermal
                                                                              Exposure                   dermal exposure Exposed skin     exposure
                                                                                Likely?     LEV present?   (ug/cm2/day)  surface (cm2)   (mg/kg/day)                                      Comments
PROC   Wide Dispersive Uses
                                                                                                                                                       EASE predicts (dispersive, mobile dust, direct handling, incidental contact). Assumes 2
 18    Greasing at high energy conditions                                        Yes            Yes            50                          0.69        hands
                                                                                                                                                       EASE predicts (dispersive, mobile dust, direct handling, intermittent contact). Assumes
                                                                                                No            1000            960          13.71       2 hands

 19    Hand-mixing with intimate contact (only PPE available                     Yes            Yes           500                          14.14
                                                                                                                                                       Values approximate to those identified in 2003 TGD and Riskofderm papers. Assumes
                                                                                                No            5000           1980         141.43       2 hands
                                                                                                                                                       EASE predicts very low (non-dispersive, non- direct handling).0.1g/cm2 a realistic
 20    Heat and pressure transfer fluids (closed systems) in dispersive use      Yes            Yes            20                          0.14        worst case. 2 hands face only
                                                                                                                                                       EASE predicts (signif breaching, direct handling, intermittent exposure). Assumes 2
                                                                                                No            250             480          1.71        hands face only

 21    Low energy manipulation of substances bound in materials and/or           Yes            Yes            10                          0.28
       articles                                                                                 No            100            1980          2.83
 22    Potentially closed operations with minerals at elevated temperature       Yes            Yes            30                          0.85
                                                                                                No            100            1980          2.83
 23    Open processing and transfer of minerals at elevated temperature          Yes            Yes            5                           0.14
                                                                                                No             50            1980          1.41
 24    High (mechanical) energy work-up of substances bound in materials         Yes            Yes            10                          0.28
       and/or articles                                                                          No            100            1980          2.83
 25    Hot work operations with metals                                           Yes            Yes            5                           0.14
                                                                                                No             10            1980          0.28
Worker Exposure report (Version 1.0) demosub
                                     PROCESS CATEGORY




Short Exposure Scenario name    Process Category
test1                           3 - Use in closed batch process (synthesis or formulation)




                                           NONE
Core Data
                CAS NO. 1/2/2003        Molecular weight 100
                                                         MODIFYING FACTORS




                        Indoors or    Ventilation     Presumed
Activity Type           Outdoors use? present?        efficiency %
Industrial              Indoors       No




                                    NONE
                     Fugacity Medium                            Inhalative Indicative Reference Value mg/m3/day
MODIFYING FACTORS
                                                                                         Dermal exposures
                                                                                         may arise from this
                                                                                         Exposure Scenario,
                               Respiratory                                               assuming a maximal
            Maximum            protection  Presumed efficiency Substance is in a         exposed skin area
            duration (hours) used?         %                   Preparation?              (cm2)
            >4 hours (default) No                              No                                         240




                                                         NONE
DNEL (10)                        Dermal Indicative Reference Value (systemic) mg/kg bw/day
                 ESTIMATE OF EXPOSURES




Inhalative       Inhalative        Dermal Exposure
Exposure         Exposure          Estimate (mg/kg      Total Exposure = Dermal +
Estimate (ppm) Estimate (mg/m3) bw/day)                 Inhalative (mg/kg bw/day)
              25       104.1666667               0.3429                        15.22385238




                                            NONE
DNEL (5)
                       RISK CHARACTERISATION RATIO




Risk Characterisation - Inhalative Margin   Risk Characterisation - Dermal
of Exposure                                 Margin of Exposure
                                10.41666667                              0.06858




                                              NONE
Risk Characterisation - Total
Margin of Exposure
                 10.48524667




                                NONE
 Worker Exposure report (Version 1.0) Phynylmercury acetate
                                      PROCESS CATEGORY




Short Exposure Scenario name        Process Category
                                    5 -Mixing or blending in batch processes (multistage and/or
Mixing and blending                 significant contact)
                                    5 -Mixing or blending in batch processes (multistage and/or
Mixing and blending                 significant contact)
Core Data
                CAS NO. 62-38-4         Molecular weight 336,75                  Fugacity
                                                         MODIFYING FACTORS




                        Indoors or    Ventilation     Presumed       Maximum
Activity Type           Outdoors use? present?        efficiency %   duration (hours)

Industrial              Indoors       No                             1 - 4 hours

Industrial              Indoors       No                             < 15 mins
High                             Inhalative Indicative Reference Value mg/m3/day

                                                          Dermal exposures
                                                          may arise from this
                                                          Exposure Scenario,
Respiratory                                               assuming a maximal Inhalative
protection  Presumed efficiency Substance is in a         exposed skin area   Exposure
used?       %                   Preparation?              (cm2)               Estimate (ppm)

No                              Yes at < 1 %                      w/w                      15

No                              Yes at < 1 %                      w/w                      2.5
                 Dermal Indicative Reference Value (systemic) mg/kg bw/day
ESTIMATE OF EXPOSURES




Inhalative       Dermal Exposure
Exposure         Estimate (mg/kg       Total Exposure = Dermal +
Estimate (mg/m3) bw/day)               Inhalative (mg/kg bw/day)

        210.46875

        35.078125
                       RISK CHARACTERISATION RATIO




Risk Characterisation - Inhalative Margin   Risk Characterisation - Dermal
of Exposure                                 Margin of Exposure
Risk Characterisation - Total
Margin of Exposure

				
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