Morphology

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Morphology Powered By Docstoc
					              Morphology                        Immunophenotype      Cyto-genetics     Clincal                 Outcome/Prognosis
SLL/CLL       - diffuse and effaced (i.e.no     CD 5, CD19, CD 20,   - trisomy 12      - adults                - indolent and incurable
              sinuses)                          CD 23                                  - asymptomatic
              - pale areas are growth centers                                          - anemia if in marrow
              - small mature lymphocytes

FL            - nodular but effaced             CD 20, CD10          Bcl-2 – IgH       - asymptomatic          - indolent and
              - follicles (homogenous                                t(14;18)          - lymphadenopathy       nonresponsive (incurable-
              infiltrate)                                                              - anemia if in marrow   grade I/II)
              - lack polarization                                                                              - grade III is aggressive
              - small cleaved cells (low                                                                       and curable
              grade)
Mantle        - diffuse and nodular             CD20, CD 5, Cyclin   Cyclin D1 – IgH   - middle aged           - aggressive course and
              - small lymphocytes               D1+                  t(11,14)          - lymphadenopathy       noncurable
                                                                                       - anemia if in marrow   - acts like high grade
                                                                                                               lymphoma even though
                                                                                                               low grade lymphoma
MALT          - monocytoid & small              CD20, CD5-, CD10-    t(11;18)          - lymphadenopathy       - indolent disease and
              lymphocytes                                            t(1;14)           - adult pt.             incurable
              - nodular and diffuse                                                    - anemia if in bone
              - lots of cytoplasm                                                      marrow
                                                                                       - *extranodal
                                                                                       involvement*
DLBCL         - diffuse                         CD20+, light chain   none              - middle aged           - aggressive and curable
              - effaced                         restriction, CD5-,                     - lymphadenopathy
              - large cells, open nuclei        C10-/+                                 - anemia if in marrow
              - mitoses
LL (ALL)      - diffuse infiltrate              CD 20-, TdTT +, CD   No single         - adults                - aggressive course but
              - medium-large cells              34+, CD 7,9,2+       translocations    - lymphadenopathy       curable
ALLBcell     - open chromatin                  *thymic phenotype*                     Tcell type gets
LLTcell      - High N:C ratio                                                         mediastinal lymph.
In LL:        - Blasts/visible nucleoli         CD10+, CD19+,                          - *nodal and
(80%)-Tcell   - mitoses                         CD34+, TdTT, light                     extranodal*
(20%)-Bcell                                     chain restriction                      - anemia if in marrow
                                                B-cell type
Burkitt’s     - diffuse and effaced             CD20, CD10, light    c-myc – IgH       Endogenous- jaw         - aggressive disease but
              - LOT of mitoses                  chain restriction    t(8;14)           mass in African         may be cured
              - tangible body macrophages       - Ki67 100% of the                     people
              showing “star sky” appearance     time                                   Commonly seen as
              - Blasts                                                                 intestinal mass
CD3+ CD4+ CD7-  Mycosis Fungoides and Sezary Syndrome

				
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posted:12/4/2011
language:English
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