HOMEOPATHIC MEDICINES IN ''POTENCY CHORDS''
Carmela M V Pedalino, DM, MSc
Homeopathic ''potency chords'' are preparations, which contain, in equal proportions,
different homeopathic dilutions prepared on the basis of one and the same original
tincture (FRASE, 1999). CAHIS in 1913 and KATZ also in 1913 introduced this
concept into homeopathy in the belief that it would produce a more evident and less
aggressive therapeutic effect (EIZAYAGA, 1981 and RECHWEG, 1992) than that
produced by single potency.
BILDET (1975) undertook a study with Phosphorus in various homeopathic dilutions,
which demonstrated their protective effect in the hepatic metabolism of female rats,
after the experimental induction of toxic hepatitis with carbon tetrachloride. BILDET et
al. (1977) developed a similar experiment, which confirmed the protective effect of
homeopathic Phosphorus, by means of the analysis of serum transaminases and of
the histological crosssection of the livers of female rats.
GOMEZ (1992) reconstructed BILDET´s experimental model with Phosphorus, but his
objective was the analysis and comparison of ''potency chord'' and the individual
potencies in induced hepatitis and concluded that there was a hepatoprotective effect
superior to that of the former.
JULIAN (1977) in his “Traité de Microimmunotérapie dynamisée” registered the
activity of the nosodia or biotherapeutic substances in ''potency chords''. Biotherapy is
the therapeutic procedure, which uses medicinal preparations obtained from microbial
products, excretion and secretions whether pathological or otherwise, animal or
vegetable and allergenic tissues (JULIAN, 1995).
One starts from the principle that different dilutions act at different sites. Thus high
dilutions (above D30) will act mainly on the nervous system, while weaker dilutions
(below D30) will act mainly on the organic tissues in a general way (BIANCHI, 1998).
Balanced dilutions or ''potency chords'' are, according to RECKEWEG (1992), the
various dilutions of one and the same substance, dynamised separately, brought
together in one and the same preparation. When the injectable form is used, one will
obtain a medicine such that each dilution contains a particular potency (frequency),
which will direct its action wherever it may be necessary, in accordance with the
tropism of the tissue or organ (AVILÉS, 1996). However, few systematic studies have
been undertaken regarding this theme, although various homeopathic ''potency chord''
preparations are to be found on the market.
JULIAN (1983) affirms that the ''potency chords'' act more rapidly, deeply and lastingly
and present fewer side effects. Thus the biophysical principles resulting from the
different ''potency chords'' could ensure different effects. Low potencies would have
their effect on “structures” consisting of a “replacement therapy”. Intermediate
potencies would have a regulating effect on the functional and biochemical chains.
High potencies would have the effect of “information” on the particular system
(SCHIMID et al., 1997).
The “replacement”, “regulating” and “information” effects will depend on the
concentrations of the substance in the organism. From 10 M (for chemical elements)
to 10 M (for hormones, cytokines etc.), that is to say, scales of potentiation up to
D15 will correspond to the “replacement” effects. “Biological regulation” will be
obtained in the scales between D8 and D30 and “biological information” as from D30
(SCHMID et al., 1997). Examples of compositions of homeopathic medicines, with
balanced ''potency chords'' (Heel Laboratories, BadenBaden, Germany):
Replacement Regulating Information
Belladona D2 D10, D30 D200,
Echinacea D10, D30 D200
Belladonna Injeel Simples ®
Replacement Regulating Information
Belladona D12, D30 D200,
I. S. D1000
Belladona D4 D12, D30 D200
1. Echinacea angustifolia Injeel Simples ®
2. Echinacea angustifolia Injeel Forte ®
Replacement Regulating Information
Echinacea D12, D30 D200
ang. I. S.
Echinacea D4 D12, D30 D200
ang. I. F.
According to HEINE (1999) few studies corroborate the affirmation regarding the
“replacement”, “regulating” and “information” effects of the ''potency chords'', though
some investigations have been undertaken into the effects of the various balanced
dilutions since 1928 by JUNKER and 1929 by VONDRACEK, with the later studies of
CIER and BOIRON (1967), BILDET (1975) and GOMEZ (1992).
JUNKER (1929) studied the effect of the dynamized substances on protozoa and
refers to the continued effect of the potencies which are gradually incorporated into
those others which we call the ''potency chords'' (RECKEWEG, 1992). VONDRACEK
(1929) studies the effect of the homeopathic dilutions of heavy metals on the
development of frogs and observed different effects for the different potencies, for
whereas certain dilutions triggered off a premature metamorphosis, others had lethal
CIER and BOIRON (1967) investigated the protective effect of the ultradiluted aloxane
in diabetic rats (experimentally induced with aloxane).They observed that the aloxane
in high homeopathic dilution inhibited induced diabetes mellitus.
BILDET (1975) investigated the protective function of Phosphorus in different
potencies in the hepatic metabolism (transaminase activity) of rats submitted to the
induced toxic hepatitis model with the administration of carbon tetrachloride.
In 1977, the same author repeated the experiment and added to it the
histopathological study of the liver, confirming his previous results.
GOMEZ (1992) repeated BILDET´s experiment and added, further, the ''potency
chords'' of Phosphorus (D10, D30, D200, D1000), the administrations being
undertaken at 12hour intervals, by intraperitoneal route (dose of 1g/kg). The
glutamicoxalacetic transaminase (GOT) was measured at 24, 48, 72 hours and one
week after the intoxication. Higher values of the transaminases were observed in the
groups treated in the first 24 hours, than in the control group, corroborating the
concept of initial “homeopathic aggravation”. It remained to be seen if this could be
attenuated with the ''potency chords'', as the following results demonstrated:
After 48 hours of intoxication, greater, highly significant differences were observed in
the serum levels of GOT among the animals treated with D30, D1000 and the
''potency chords'', than in those of the control group.
It was also observed that the high potencies as well as the ''potency chords'' (including
the high potencies) presented greater effect than the lower potencies.
After 72 hours, the results of the transaminases were significant in all the groups
studied, in relation to the control group, with the exception of the group treated with
The values of the transaminases returned to normal in all the groups after a week. All
the experiments were confirmed by the histopathological exam. The experiment
showed clearly that the effect of the ''potency chords'' differs from that produced by
each of the dilutions separately.
GOMEZ (1992) widened these experiments, testing the efficacy of the ''potency
chords'' in diminishing the initial homeopathic aggravation, by administering repeatedly
the preparations of Phosphorus, even in the high potencies. Individually, the highest
values of transaminases were found in the groups of D10 and D1000, which did not
happen with the administration of the same potencies in “sympathy”. It was deduced
a) the ''potency chords'' possess an effect of their own, even though they may
contain a total number of molecules of the active principal equal to that of the D10
b) the effect of the ''potency chords'' is clearly differentiated from the individual
effects of the dilutions which they contain;
c) the classical initial homeopathic aggravations appear but are clearly reduced with
the use of the ''potency chords''.
Many questions and hypotheses regarding the full elucidation of the ''potency chords''
still await clarification, especially in the biophysical field and in the interrelations of the
There are few publications which deal with the effects of the use of homeopathic
medicines in ''potency chords'' (BILDET, 1975; GOMEZ, 1992).
PEDALINO et al. (2004) published a study which sought to focus on the role of the
macrophage as an indicator of the evolution of experimental peritonitis, in view of the
central role of this cell in the processes of immunological modulation in face of stress
and situations of challenge to external agents (OTTAVIANI and FRANCESCHI, 1998).
The effects of two plants (Atropa Belladona and Echinacea angustifolia) contained in
the same medicine, in ''potency chord'', were observed and were compared to those of
the positive and negative control (Phase A). After the evidences supporting the
modulating effects of the inflammation in this commercial preparation (Belladona
Homaccord ®) had been observed, the investigation advanced in two further phases,
B and C. Under the experimental conditions used in the study, both Atropa Belladonna
and Echinacea angustifolia possessed a modulating effect on the inflammatory
peritonitis inflammation provoked by LPS in mice. The plants studied modified the
cellular migration to the inflammatory focus by making the process more acute:
increasing the cellular migration of polymorphonuclear cells and reducing the
migration of lymphocytes and macrophages. This effect was more evident in the
preparations which contain low potencies, such as D4.
Atropa belladonna was more efficacious than Echinacea angustifolia as regards the
effects on macrophage activity, especially when in the higher ''potency chords''. All the
preparations of Echinacea angustifolia and Atropa Belladonna studied presented a
reduction in the percentage of degenerate leucocytes present at the site of the
inflammation, suggesting a less damaging effect on these cells.
We conclude that the ''potency chords'' may constitute a resource in the study and use
of the plants with additional effect and may lead to better use of the results and fewer
clinical aggravations as well as of cellular lesions or greater protection of the tissue.
We suggest to researchers that further studies should be undertaken focusing on
''potency chords'' and their effects on pathologies and tissues.
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