Vitamin Deficiency Vitamins are necessary in small amounts for normal metabolism and good health. Vitamins are of vital importance in maintaining human health. Vitamins assist in the formation of hormones, blood cells, nervous-system chemicals, and genetic material. Vitamins mainly serve as catalysts for certain reactions in the body. They combine with proteins to create metabolically active enzymes that in turn produce hundreds of important chemical reactions throughout the body. They are required to do many things and their excess or depletion can lead to acute and chronic disease. Deficiencies of most of the vitamins will result in corresponding diseases. Vitamin A is essential for the functioning of the immune system. Vitamin A deficiency occurs with the chronic consumption of diets that are deficient in both vitamin A and beta-carotene. People most at the risk of vitamin A deficiency are children between six months to six years, pregnant women, and lactating women. For children, vitamin A deficiency causes severe visual impairment and blindness, and significantly increases the risk of severe illness, and even death, from such common childhood infections as diarrhea disease and measles. Vitamin B1 (Thiamin) is essential for the body to be able to use carbohydrate as an energy source as well as for metabolizing amino acids. Thiamine deficiency occurs as a result of many factors, including crash dieting, alcohol abuse, liver dysfunction, kidney dialysis, and sustained periods of IV nutrients. A lack of sufficient thiamine in the diet can cause loss of appetite, poor digestion, and chronic constipation, loss of weight, mental depression, nervous exhaustion, and insomnia. It can lead to muscular weakness, leg cramps, slow heartbeat, and irritability, defective hydrochloric acid production in the stomach and consequent digestive disorders. Vitamin B2 (Riboflavin) is a water-soluble vitamin needed to process amino acids and fats activate vitamin B6 and folic acid, and help convert carbohydrates into the fuel the body runs on adenosine triphosphate (ATP). Riboflavin deficiency has profound effects on the metabolism of carbohydrates, fats, and protein. The most common cause of riboflavin deficiency is dietary inadequacy, which occurs in those who do not consume rich dietary sources of the vitamin. A deficiency of vitamin B2 (Riboflavin) may result in bloodshot eyes, abnormal sensitivity to light, itching and burning of the eyes, inflammation in the mouth, a sore and burning tongue, and cracks on the lips and in the corners of the mouth. Vitamin B3 (Niacin) is used by the body to release energy from carbohydrates. Vitamin B3 contributes to more than 50 vital bodily processes. A Niacin deficiency often leads to a chronic illness called pellagra, characterized by gastrointestinal problems, lesions of the skin, and dementia. If left untreated, death is the usual outcome of pellagra. Because of its unique relationship with energy production, vitamin B3 deficiency is often associated with general weakness, muscular weakness, and lack of appetite. The most common symptoms of niacin deficiency involve the skin, digestive system, and the nervous system. Vitamin B3 deficiency is rare, but can occur in alcoholics, individuals with poor or irregular diets and in individuals with medical conditions causing malabsorption from the intestinal tract. Vitamin B5 (Pantothenic acid) is essential for human growth, reproduction and many normal bodily processes. Pantothenic acid deficiency is extremely rare in any but the most impoverished societies and is generally associated with severe nutritional deficiencies such as Kwashiorkor or marasmus. Pantothenic acid deficiencies may occur in people with alcoholism but are generally believed to be rare. Symptoms of a vitamin B5 deficiency may include fatigue, insomnia, depression, irritability, vomiting, stomach pains, burning feet, and upper respiratory infections. Vitamin B6 is essential in numerous biochemical pathways involving red blood cells, the immune system, central nervous system function, protein metabolism, homocysteine metabolism, and also the production of energy. Vitamin B6 deficiency is usually associated with poor absorption of nutrients in the gastrointestinal tract, the taking of certain drugs that inactivate the vitamin, with genetic disorders that inhibit metabolism of the vitamin, or in cases of starvation. Vitamin B6 deficiency can cause impaired immunity, skin lesions and mental confusion. People with kidney failure have an increased risk of Vitamin B6 deficiency. Folic acid is a B vitamin needed for cell replication and growth. The demand for folic acid increases when human cell growth is very active, such as in pregnancy, during breastfeeding, growth and some cancers. Folic acid deficiency is one of the most common nutritional deficiencies and has been observed in alcoholics, pregnant women, and people living in institutions. Folic acid deficiency may cause poor growth, graying hair, inflammation of the tongue (glossitis), mouth ulcers, peptic ulcer, and diarrhea. It may also lead to certain types of anemias. Toxicity from excessive folic acid intake does not normally occur, as folic acid is water soluble and regularly excreted by the body. Vitamin B12 is essential for the proper production of blood platelets and red and white blood cells, the manufacture of vital substances needed for cell function, and the metabolism of nutrients necessary for cell growth. Vitamin B12 deficiency can be a factor in a variety of different health conditions and disorders. B12 deficiency inhibits of severy decrease the bodies ability to produce blood, increases blood cell destruction, and is very harmful to the nervous system. A deficiency of vitamin B12 (cobalamin) deficiency can cause pernicious anemia, which is marked by fewer but larger red blood cells. Deficiencies can cause walking and balance disturbances, a loss of vibration sensation, confusion, and even dementia. Vitamin C is an essential nutrient for humans. Vitamin C is an important antioxidant vitamin involved in the development of connective tissues, lipid and vitamin metabolism, biosynthesis of neurotransmitters, immune function, and wound healing. Vitamin C deficiency results in an under hydroxylation of proline and lysine in collagen which results in a lower melting temperature of the resulting collagen fibers which causes a breakdown of the protein collagen needed for connective tissue, bones and dentin, the major portion of teeth. A severe form of vitamin C deficiency is known as scurvy, which mainly affects older, malnourished adults. Vitamin D is a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. Vitamin D is most often associated with calcium metabolism and bone formation. In adults, Vitamin D deficiency may result in a softening of the bones known as osteomalacia. In children, Vitamin D deficiency is called rickets and causes a bowing of bones not seen in adults with vitamin D deficiency. Vitamin D deficiency can be caused by conditions that result in little exposure to sunlight. Vitamin E (tocopherol) is a powerful antioxidant which protects cell membranes and other fat- soluble parts of the body. Vitamin E deficiency strikes people with diseases that prevent the absorption of dietary fats and fat-soluble nutrients. Vitamin E deficiency is rare in humans. Vitamin E deficiency affects the central nervous system and may result in progressive neuromuscular disease characterized by loss of reflexes, muscle weakness, loss of balance and impaired ability to coordinate voluntary movements (ataxia). Vitamin K plays an important role in blood clotting and bone metabolism (carboxylation of osteocalcin). Vitamin K deficiency is often the result of impaired absorption rather than not getting enough in the diet. Individuals with vitamin K deficiency usually have an increased propensity to bruising and bleeding. Deficiency can occur in persons of any age but neonates are at risk of developing hemorrhagic disease of the newborn. Symptoms of vitamin K deficiency include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria.
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