nernst by huanghengdong

VIEWS: 6 PAGES: 2

									                                   77fb35e8-69ad-4fc0-b25d-de9378f1f807.xls


          Values for Squid, from Book, p. 95, 99, 104
Squid Giant Axon              K        Na          Cl       Ca conc=mM
          out                20       440         560        10 alter these values
          in               400         50          51       0.4 to see results change
          Prp                 1      0.04        0.45
          Pap                 1        20        0.45                   R=        8.31 Joules / (mole * K) (Gas Constant)
Nernst Solutions                                                        T=         293 K (temperature -degrees kelvin)
     Ek= -75                    Goldman Solution                        F=      96500 Coulomb / mole
    Ena= 54                         Vm= -60           mV            RT/F= 0.025231 volts
     Ecl= -60
    Eca= 80                         Vm=       RT         ln     Pk[K]o + Pna[Na]o + Pcl[Cl]i
          mV                                   F                Pk[K]i + Pna[Na]i + Pcl[Cl]o

Squid                         K           Na        Cl             Ca
          out                20          440       560              10
          in                400           50        51             0.4
          Prp                 1        0.045      0.45
          Pap                 1           20      0.45


          "I'd have to be dummer than a bucket of hair..."
          CNN news something in FortWorth Texas (11:35PM, 1/19/98)

Cat Motor Neuron              K           Na        Cl
          out                5.5         150       125
          in                150           15         9
          Prp                  1        0.04      0.45
          Pap                  1          20      0.45                         R=      8.31
Nernst Solutions                                                               T=       293
     Ek= -83                       Goldman Solution                            F=    96500
    Ena= 58                            Vm= -65           mV                 RT/F= 0.025231 volts
     Ecl= -66
          mV                            Vm=     RT            ln         Pk[K]o + Pna[Na]o + Pcl[Cl]i
                                                 F                       Pk[K]i + Pna[Na]i + Pcl[Cl]o


Cockroach Muscle              K           Na        Cl
          out                27          111       150
          in                110           27        44
          Prp                 1         0.04      0.45
          Pap                 1           20      0.45                         R=      8.31
Nernst Solutions                                                               T=       293
     Ek= -35                       Goldman Solution                            F=    96500
    Ena= 35                            Vm= -32           mV                 RT/F= 0.025231 volts
     Ecl= -31
          mV                            Vm=     RT            ln         Pk[K]o + Pna[Na]o + Pcl[Cl]i
                                                 F                       Pk[K]i + Pna[Na]i + Pcl[Cl]o




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                                            77fb35e8-69ad-4fc0-b25d-de9378f1f807.xls




Joules / (mole * K) (Gas Constant)
K (temperature -degrees kelvin)
Coulomb / mole




                      Kelvin scale = 0 = absolute zero (0C = 273.15K)

                      R = Gas Constant (R in PV=nRT)
                      R = 8.3145 Joules / (mole * K)
                      Unit : Joule = watt * sec = amp * volt * sec
                             R = J/mole/sec = (amp * volt * sec) / (mole * K)

                      F = Faraday's Constant
                      charge carried by Avagadro's number of electrons
                      96484 C/mol ; C = Coulumb
                      charge of one electron is 1.602 e-19 Coulombs
                      (1 mol of electrons = 1F = 96500 C)
                      Unit: Coulomb = amp * sec
                            F = C/mol = (amp * sec) / mole

                          RT/F= ((amp * volt * sec) / (mole * K)) * K
                                        (amp * sec) / mole

                          RT/F= volt




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