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					           Principal Investigator/Program Director (Last, First, Middle):


                                                         BIOGRAPHICAL SKETCH
                               Provide the following information for the key personnel in the order listed for Form Page 2.
                                         Follow this format for each person. DO NOT EXCEED FOUR PAGES.


  NAME                                                                          POSITION TITLE

   Xie, Guo-Xi                                                                  Associate Researcher

  EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

  INSTITUTION AND LOCATION                                                  DEGREE               YEAR(s)               FIELD OF STUDY
                                                                            (if applicable)
  Medical University, China                                                        MD                 1976             Medicine
  Beijing Medical University, Beijing, China                                       PhD                1984             Physiology and
                                                                                                                       Neurobiology
  Stanford University School of Medicine                                       Post-doc             1985-88            Opioid Pharmacology
  and Addiction Research Foundation, Palo Alto                                                                         and Molecular Biology



A. Positions and Honors.

Professional Experience:
1976 --- 1979 Physician, Department of Internal Medicine, Junan Hospital, Shandong province, China
1981 --- 1982 Teaching Assistant for Physiology and Experimental Physiology courses, Beijing Medical
              University, Beijing, China.
1984 --- 1985 Lecturer, Department of Physiology and Neuroscience Center, Beijing Medical University,
              Beijing, China.
1985 --- 1988 Postdoctoral Fellow, Addiction Research Foundation, Palo Alto, and the Department of
              Pharmacology, Stanford University School of Medicine, Stanford, California, USA.
1986 --- 1988 Visiting Scientist, supported by DNAX Research Institute and Stanford University.
1988 --- 1991 Postdoctoral Fellow, Department of Molecular Biology, DNAX Research Institute of Molecular
              and Cellular Biology, Palo Alto, California.
1992 --- 1994 Senior Research Associate, Neuropeptide Laboratory, Mental Health Research Institute,
              University of Michigan, Ann Arbor, Michigan.
1994 --- 1997 Scientist, Spectra Biomedical, Inc., Menlo Park, California
1997 --- 2000 Assistant Researcher, University of California, San Francisco, Department of Anesthesia
2000 -present Associate Researcher, University of California, San Francisco, Department of Anesthesia
Honors and Awards:

1992-1993           The University of Michigan Peptide Research Center Research Grant recipient.
12/99 – 11/2004 NIH RO1 AR45570 – Nociceptin and ORL1 receptor in synovial inflammation/pain: Co-
Investigator
12/2003 - 11/2007 NIH R01 NS042593                           - Transcription regulation and interaction of ORL1 and GAIP: Co-
Investigator

B. Selected peer-reviewed publications (in chronological order).

1. Xie GX, Xu H, Han JS: Involvement of spinal cord Met-enkephalin and dynorphin in descending morphine
   analgesia. Acta Physiologica Sinica 36: 457-463, 1984.
2. Han JS, Xie GX, Goldstein A: Analgesia induced by intra-thecal injection of dynorphin B in the rat.
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          Principal Investigator/Program Director (Last, First, Middle):


   Life Sci. 34: 1543-1579, 1984.
3. Xie GX, Goldstein A: Characterization of big dynorphins from rat brain and spinal cord. J. Neurosci.
   7: 2049-2055, 1987.
4. Xie GX, Miyajima A, Yokota T, Arai KI, Goldstein A: Chimeric opioid peptides: Tools for identifying
   opioid receptor types. Proc. Natl. Acad. Sci. USA 87: 3180-3184, 1990.
5. Xie GX, Miyajima A, Goldstein A : Expression cloning of cDNA encoding a seven-helix receptor from
    human placenta with affinity for opioid ligands. Proc. Natl. Acad. Sci. USA 89: 4124-4128, 1992.
6. Akil H, Meng F, Thompson R, Mansour A, Xie GX, Watson SJ: Molecular studies of multiple opioid
    receptors: cloning, anatomical distribution, pharmacological profile. Regulatory Peptides S1: 9-10, 1993.
7. Meng F, Xie GX, Thompson RC, Mansour A, Goldstein A, Watson SJ, Akil H: Cloning and
   pharmacological characterization of a rat k opioid receptor. Proc. Natl. Acad. Sci. USA 90: 9954-9958,
    1993.
8. Xie GX, Meng F, Mansour A, Thompson RC, Hoversten M, Goldstein A, Watson S, Akil H:
    Primary structure and functional expression of a guinea pig kappa opioid (dynorphin) receptor. Proc.
    Natl. Acad. Sci. USA 91: 3779-3783, 1994.
9. Fickel J, Xie GX, Thompson RC, Watson SJ, Akil H: Cloning of potential candidates for guinea pig
    opioid receptors. Regulatory Peptides, 54: 93-94, 1994.
10. Meng F, Xie GX, Chalmers D, Morgan C, Watson SJ, Akil H: Cloning and expression of the A2a adenosine
    receptor from guinea pig brain. Neurochem. Res., 19: 613-621, 1994.
11. Meng F, Xie GX, Chalmers D, Morgan C, Watson SJ, Akil H: Cloning and characterization of a
    pharmacologically distinct A1 adenosine receptor from guinea pig brain. Mol.Brain Res., 26: 143-155,
    1994.
12. Xie GX, Maruyama K, Miyajima A: Construction of mammalian brain size-fractionated cDNA expression
    library and expression cloning of neuropeptide receptor by ligand binding. Neuroscience Protocols, 2: 1-17,
    1995.
13. Pierce PA, Xie GX, Peroutka SJ, Levine JD: 5-Hydroxytryptamine-induced synovial plasma extravasation
    is mediated via 5-HT2A receptors on sympathetic efferent terminals. J. Pharmacol. Exper. Ther., 275: 502-
    508, 1995.
14. Akil H, Meng F, Mansour A, Thompson R, Xie GX, Watson S: Cloning and characterization of multiple
    opioid receptors. NIDA Res. Monogr., 161: 127-140, 1996.
15. Pierce PA, Xie GX, Peroutka SJ, Levine JD: Dual effect of the serotonin agonist, sumatriptan, on peripheral
    neurogenic inflammation. Regional Anesthesia, 21: 219-225, 1996.
16. Pierce PA, Xie GX, Levine JD, Peroutka SJ: 5-Hydroxytryptamine receptor subtype messenger RNAs
    in rat peripheral sensory and sympathetic ganglia: A polymerase chain reaction study. Neuroscience,
    70: 553-559, 1996.
17. Pierce PA, Xie GX, Meuser T, Peroutka SJ: 5-Hydroxytryptamine receptor subtype messenger RNAs
     in human dorsal root ganglia: a polymerase chain reaction study. Neuroscience, 81: 813-819, 1997.
18. Xie GX, Jones K, Peroutka SJ, Pierce Palmer P: Detection of mRNAs and alternatively spliced transcripts
    of dopamine receptors and transporter in rat peripheral sensory and sympathetic ganglia. Brain Res., 785:
    129-135, 1998.
19. Xie GX, Meuser T, Pietruck C, Sharma M, Pierce Palmer P: Presence of opioid receptor-like (ORL1)
    receptor mRNA splice variants in peripheral sensory and sympathetic neuronal ganglia. Life Sci., 64:2029-
    2037, 1999 .
20. Pietruck C, Xie GX, Sharma M, Meuser T, Pierce Palmer P: Multiple splice patterns of cyclic AMP
    response element-binding protein mRNA in the central nervous system of the rat. Mol. Brain Res., 69:
    286-289, 1999.
21. Pietruck C, Xie GX, Sharma M, Meuser T, Pierce Palmer P: Alternative exon splicing of cyclic AMP
    response element-binding protein in peripheral sensory and sympathetic ganglia of the rat. Life Sci., 65:
      2205-2213, 1999.
22. Xie GX, Ito E, Maruyama K, Suzuki Y, Sugano S, Sharma M, Pietruck C, Pierce Palmer P: The promoter
    region of human prepro-nociceptin gene and its regulation by cyclic AMP and steroid hormones. Gene,
    238:427-436, 1999.
23. Xie GX, Ito E, Maruyama K, Pietruck C, Sharma M, Yu LC, Pierce Palmer P: An alternatively spliced
    transcript of the rat nociceptin receptor ORL1 gene encodes a truncated receptor. Mol. Brain Res.,77: 1-9,
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          Principal Investigator/Program Director (Last, First, Middle):


    2000.

24. Ito E, Xie GX, Maruyama K, Pierce Palmer P: A core-promoter region functions bi-directionally for human
    opioid-receptor-like gene ORL1 and its 5’-adjacent gene GAIP. J. Mol. Biol., 304: 259-270, 2000.
25. Grond S, Gabriel A, Pietruck C, Yu LC, Xie GX, Pierce Palmer P: Bi-directional modulation of 5-
    hydroxytryptamine-induced plasma extravasation in the rat knee joint by nociceptin. Neuroscience, 103:
    1085-1092, 2001.
26. Lu JT, Huang YH, Pierce Palmer P, Xie GX, Gabriel A, Grond S, Yu LC: Blockade effect of
    (NPhe1)nociceptin(1-13)-NH2 on anti-nociception induced by intrathecal administration of nociceptin in
    rats. Regulatory Peptides, 101: 81-85, 2001.
27. Xie GX, Wang Y, Sharma M, Gabriel A, Mitchell J, Xing YL, Meuser T, Pierce Palmer P: 5-
    Hydroxytryptamine-induced plasma extravasation in the rat knee joint is mediated by multiple
    prostaglandins. Inflammation Research, 2002, in press.
28. Meuser T, Pietruck C, Gabriel A, Xie GX, Lim K, Pierce Palmer P: 5-HT7 receptors are involved in
    mediating 5-HT-induced activation of rat primary afferent neurons. Life Sci. 71:2279-2289, 2002.
29. Xie, G.X., Han, X.K., Ito, E, Yanagisawa, Y., Maruyama, K., Sugano, S., Suzuki, Y., Wang, Y., Gabriel, A.,
    Stevens, S.K., Mitchell, J., Sharma, M., Pierce Palmer, P. Gene structure, dual-promoters and mRNA
    alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19. J. Mol. Biol.,
    325: 721-732, 2003.


C. Research Support
Ongoing Research Support

NIH RO1 AR45570 (12/99 – 11/2004) – Nociceptin and ORL1 receptor in synovial inflammation/pain: Co-
            investigator with role on project involving performing PCR, in situ hybridization, and
            immunocytochemistry experiments. This project is attempting to determine the role of the
            nociceptin/ORL1 system in peripheral inflammation/pain mechanisms. To date most research
            has focused on the effects of nociceptin in the CNS and PNS.

NIH R01 NS042593 (12/2003 - 11/2007) - Transcription regulation and interaction of ORL1 and GAIP: Co-
             Investigator




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