cancer

Alternative Tx for advanced cancers

Dr. Jimmy Chan ND and acupuncturistbastyr grad and board trustee and co-founder of

dept of TCM

Vancouver, BC



Spent time at UCLA „pretending‟ to be an MD



Dr. ravechiCA Tx



What is CA

 A greek worda crab

 Cells tend to be immortal because apoptotic gene is turned offcan grow even

after host dies

 Slowest growing malignancy is prostate CAmost CA grows 9x faster

 Prostate CA almost never kills a man, regardless of Txquality of life is not

affected. In Canada they will not pay for the first PSA screen

 Initial phase can take 5-7yrs before reaching a clinically detectable size

(1cm10^9 # of cells)

 Conventional Tx is cut, burn and poison

 Debulking

 chemotherapyhas been used in TCM, pacific yew. Can you really have enough

concentration to kill CA cells

 free radical Txradiation. DNA binding is –10 electron volts which can be

destabilized by ionization effect of radiationpts should be well hydrated to

prevent DNA damage (how does this affect the killing of CA cells??)

 CA cells are stickythin blood and give digestive enzymes, modified citrus

pectin

 2 types of cell death

o necrosis

 lots of side affects when this is induced

 Tx

o somatostatinanti-growth hormone which must be administered

throughout the life-time. UCLA (dr. block) used just for compassionate,

palliative management of sx‟s

o butyrate- old test looking at stool butyrate to evaluate colon CA risk

o citrous pectinfuel for rockets and explosivesat small conc it inhibits a

key enzyme CA cells use to survive anerobically

o wobenzymedownregulates TGF-beta 1 and maybe CQ1 receptors to

enhance cell response rate

o shroom extractsmodulated NK cell activity

o NPC/bacteria may prime immune system to be more active against CA

o Anti-angiogenesisshark cart

o Urine therapydoc in texasis currently going through FDA review

o IV vit C at high doses can genereate enough free radicals and reactive

species to weaken CA cells

o POLY-MVA- mitochondrial inhibitor



Biologic Tx

 Insulin therapyinvented by dr ??? insulin to potentiate low dose chemo. CA

cells have much more insulin receptor sites on surface and we are utilizing that

characteristic to open up the channels and concentrate chemo. Also insulin can 

K inside cell and reverse the Na/K ration. Hyperkalemia is treated by giving

insulin to induce cells to uptake potassium. This is called a polarization therapy.

 Photodynamic therapy

o 1900

o acodine orange plus UV light killed bacteria

o eosin and UV light to Tx skin CA in 1903

o hemotoporhyrin (break down product of Hgb) used to Tx CA

 light is used to Tx jaundice esp in newborns to prevent possible

brain retardationBBB is not well formed. Don‟t Tx adults this

way because we don‟t allow billirubin to cross and our

neurological syst is already developed. When biliruben absorbs

light an electron can hop off and cause a free radical formation to

be released in the periphery and not the CNS???

o Using a photosensitizer that is taken up by abnormal tissue

o Singled oxygen has biphasic effect on cellscan be used for macular

degeneration and endometriosis. Catching on in cosmetic industry.

o Can reproduce PDT naturally by flexing muscles (oxygen tension) in

bright sunshine (absorbtion of energy) and breaking up hemoglobin. Run

around in the nude in the sun

 Cell signaling therapies

o Homeopathics thought of as a signal

 UW scientist who has done research in homeopathic growth

hormone that works as a signal.

o Lots of protein molecs can initiate cellular activities

 caspasescascade of enzymes that causes apoptosis

o growth factors

 signaling proteins

o anti-neogenesis

 CA cells produce many growth factors to entice the growth of new

blood vessels. These vascular epithelial growth factors are

produced by tumor and acts on nearby blood vesselprotein

degrades vessel wall and causes vessel to grow toward tumor.

Also helps tumor cells break through vessels and enter blood

streamThis process is greatly enhanced by vascular injury

(including surgery) CA cells can also obtain nutrients by pure

diffusioncutting off blood supply is not totally effective

o Green tea

o New Treatments

 1970s research from japan on ginsengosidescopies available by

calling his office or pegasys office

 most compounds in ginseng have no effect on CA cell growth and

some have CA promoting effects. Has memory and immune

system affects

 anti-CA ginsengosides are small in amount in general

 the only formula in TCM that has only one herb contains ginseng.

 Could be due to the diverse properties and action of G

 The younger the ginseng the sweeter the root and older wildcrafted

is bitter. Aglycone of ginsengs may work betterinduces

apoptosis through caspase pathways. Apoptosis does not induce

any inflammatory response or cause any negative affect on the

body (is this true????)

 aglycone

 A pancreatic CA study showed that aglycones work

independent of caspases (independent of genetic

variations/deficiencies)

 Also inhibts growth on brain tumor models

 Can be used as a sensitizer

o When you hit w/ chemo you will have some mutant

survivors which develop multiple drug resistance

and repopulate the tumorafter several Tx

regiemesthey eventually say that it is an

untreatable tumor and shift to palliative Txs

 Big on standardization to make sure you get a “sure hit”

 PGPpump which pumps poisons out of cells

 Found on baby cellsactivating these pumps on baby cells

can allow for chemo given to pregnant women. Blocking

PGP pump in detox organs leads to death. This is a

quandary in medicine. This aglycone which came from

nature only enhances drug concentration of bad cells.

 The more resistant the CA cells arein the presence of this

aglycone the more they will be killed at lower

concentration of poison. Mechanistic pathway for this is

being researched

 Clinical studies

 Done in his office because ND‟s are allowed to use

anything of natural origin in any route (IV) and are out of

reach of medical board. The government has no right to

tell ND‟s how to practice.

 10million dollars spent on research and lobbing

 American society of clinical psychology (ASCO) abstract

in 2003

 Approved in China for adjuct CA therapy

 COX inhibitor can  success of liver chemo Tx

 Glucocorticoids given prior to brain CA Tx because there is

no way to ensure entire apoptotic cell deathsome

necrosis may occur w/ inflammatory response which is an

issue in skull where space is limited

 Vaccines

 Small molecules that are biological response modifierssome from ginseng

 Cancer 1994 sept. 1:74 p 1652-2detecting CA below 1 cm size

 www.drjimchan.comslides on site

 vit C provides DNA stabilization

 Kobayashi MD showed in an unpublished paper that diet (ACE supplementation)

and lifestyle (stress reduction, stop smoking, exercise) reduced CA risk by 46%

o Infared saunas, whirl-pool baths, massage therapy

o Sun adventec  risk by 46.5%

 Walter blumer, MD

o Pushed Caa-EDTA into pts and found 90% reduction in CA

o Toxic metal reduction can be possible preventative measure

 Careseng sales pitch