Postdoctoral Fellowships
Molecular Neurobiology of Neurotransmitter Transport
Vanderbilt University Department of Pharmacology
Center for Molecular Neuroscience
Several postdoctoral positions are available for talented, energetic fellows interested in studying the
regulation of neurotransmitter transport. Areas of special interest are listed below:
Macromolecular Organization of Signaling/Transporter Complexes: Fellows will investigate serotonin
and norepinephrine transporter-associated proteins and their roles in transporter trafficking and receptor-
activated transporter regulation
Genetic Evaluation of Transporter Modulators in C. elegans. Fellows will utilize a genetic approach to
identify modulators of the C. elegans dopamine transporter. Candidates with experience in the C. elegans
model and an interest in synaptic neurobiology are encouraged to apply.
Human Genetics of Transporter Diseases: Fellows will utilize state-of-the art technologies for
investigating single nucleotide polymorphisms in serotonin transporters as they relate to CNS and PNS
disorders.
Research will be performed in the Biological
Sciences/MRBIII Research Facility, Vanderbilt
University’s newest research facility, slated to
open in June of 2002. The Blakely laboratory is
supported by multiple NIH and private foundation
grants and is well equipped with modern tools for
recombinant and native transporter evaluation
(see also See also http://www.blakelylab.org).
Research is supported by established core
laboratories for confocal imaging, mass
spectrometry and neurogenomics. Opportunities
for collaborations with the adjacent
electrophysiology laboratories of Louis DeFelice
and Aurelio Galli are also available. Interested
fellows currently completing graduate study or in
the early years of postdoctoral study should send
a C.V. and the names of three references via
email to randy.blakely@vanderbilt.edu.
References:
Bauman AL, Apparsundaram S, Ramamoorthy S, Wadzinski BE, Vaughan RA, Blakely RD. Cocaine and
antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase
2A. J Neurosci. 2000 Oct 15;20(20):7571-8.
Apparsundaram S, Sung U, Price RD, Blakely RD. Trafficking-dependent and -independent pathways of
neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase in
studies of insulin modulation of norepinephrine transport in SK-N-SH cells. J Pharmacol Exp Ther. 2001
Nov;299(2):666-77.
Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D. Orthostatic
intolerance and tachycardia associated with norepinephrine-transporter deficiency. Engl J Med. 2000 Feb
24;342(8):541-9.
Nass R, Hall DH, Miller DM 3rd, Blakely RD. Neurotoxin-induced degeneration of dopamine neurons in
Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3264-9.
Ulteriori informazioni presso Antonio Peres o Elena Bossi