Supplementary Table: Pulmonary and pleural effusions, pneumonitis
Grade* Attribution** Required intervention
Pleural effusion
07201 1 4 No
07204 2 4 Yes (diuretics, steroids, drug interruption)
07205 3 4 Yes (admitted, diuretics, oxygen, drug discontinuation)
07208 1 3 No
07209 1 3 No
07211 1 4 Yes (drug discontinuation)
07213 2 4 Yes (diuretics, steroids)
07216 3 2 Yes (drug discontinuation)
07217 1 3 No
07218 2 3 No
07220 2 4 Yes (diuretics, drug discontinuation)
07222 2 4 Yes (diuretics, drug interruption)
07224 2 4 No
07225 2 4 Yes (diuretics, drug discontinuation)
07226 3 3 Yes (diuretics, steroids, thoracentesis, drug discontinuation)
08201 2 3 No
Pericardial effusion
07204 1 3 Yes (diuretics, steroids, drug interruption)
07222 1 4 Yes (diuretics)
Pneumonitis
07207 3 4 Yes (steroids, drug discontinuation)
07213 3 4 Yes (diuretics, steroids)
07224 2 4 No
* Grade scale: 1= mild; 2= moderate; 3= severe; 4= life-threatening; 5= death
** Attribution scale: 1= unrelated to study drug; 2= unlikely related; 3= possibly related; 4= likely related; 5= related
Toxicity resolution with dasatinib discontinuation
Yes
Yes
Yes
Yes
Unknown
Unknown
Unknown
Unknown
Yes
Yes
Unknown
Yes
Yes
Yes
Yes
Unknown
Unknown
Yes
Yes
Unknown
Yes
d; 5= related