Predicting the Future
April 6, 1992
…Antioxidants may one day
revolutionize health care.
…Foresees screening people
through a simple...test to
assess how much damage free
radicals have done to tissue,
much as patients today are
screened for high cholesterol.
Biochemist, William Pryor,
director of the Biodynamics Institute at
Louisiana State University
The Constant Battle
Free Radicals are toxins that
cause cell and DNA damage
Antioxidants combat free radicals
to prevent cell damage and maintain
health
Free Radical Sources
· Sunlight
· Stress Smoking
· Toxins
· Pollution 10 Quad Trillion free
· X-rays radicals per cigarette!
· Radioactivity
· Airline travel
· Medications
· Food additives
· Environmental Chemicals
· Synthetic materials
· Household cleaners
· Solvents
· Pesticides
· Herbicides
Antioxidant Sources
A diet rich in
FRUITS and
VEGETABLES
And
Nutritional
Supplements
What is Your Level?
"The amount of antioxidants that
you maintain in your body is
directly proportional to how long
you will live.“
Dr. Richard Cutler, while Director of the
Anti-Aging Research Department of the
National Institutes of Health, Wash D.C.
Nutritional Deficit
+
- Latent Nutritional Deficit (Accumulates)
0 20 40 60 80 100
Poo
f
Nutritional Deficit
+
Erase the Deficit
-
0 20 40 60 80 100
Indisputable
3 Decades
30,000 Published Papers
Document the link
between
Free Radical Activity
and Cell Damage
The Team
Developed at the Center
for Bio-Medical Optics at
the University of Utah
Site of Action
The Location where
Free-Radicals and
Antioxidants do
Battle!
Scanner Science is Measurable
-Feb 2003
-Feb 2003 and Feb 2004
-April 2003 and April 2004
FASEB / American Society of Nutritional Sciences
-Jan 2004
Review paper pending publication in
Current Topics in Nutraceutical
Research, May 2004
Patents
Key Patent issued
March 20, 2001
8 Patents Total
in the US,
Europe and Asia
Global Exclusive Rights
Has
Global Exclusive
Rights to the
Technology for the
Next 15 Years
The Biggest Revolution
The U.S. Wellness
Industry is Growing
at a rate of
$90 million a day
… And there is no
end in sight
PROOF
The BIO-PHOTONIC SCANNER
*$18.8 Billion Spent in 2003 –
And No One Knows if They
Work or Not!
*Source: NBJ 2003
Wellness Revolution Trend
Sub-Clinical Measurement Clinical Diagnosis
• Identify Situations Now • Wait until it is too late
• Make Course • Decades of Damage
Corrections
• Only Options:
• Remedy is Nutritional – Surgical
– Pharmaceutical
What is the Depth of your Nutritional Deficit?
Company – NSE & Pharmanex
• $1 Billion in Annual Sales
• D&B 5A-1 Rating
• 20 Year Track Record
• $600 Million in Paid for Assets
• Global Seamless Comp. Plan
• $120 Million Cash in Bank
• Operating in 37 Countries
• Publicly Traded – NYSE (NUS)
Investors’ Business Daily
“NSE/Pharmanex might have
a secret weapon...It's called
the BioPhotonic Scanner…”
April 16, 2004
Catch the Wave
North America
Massive LifePak Sales
$1 Billion
20,000
$500 Million Scanners
Deployed
Early
Scanner
Launch
$50 Million
1998 2003 2004* 2005 2006 2007 2008
Dentist Opportunity
Powerful New Weapons in
the Fight Against
Periodontal Disease
What the latest research tells us.
What it means for your patients.
What it means for you.
Current Clinical Protocols:
Up until now, our primary clinical weapons against
periodontal disease have been SRP, antibiotics,
and surgery.
Yet we know from clinical research that SRP is
ineffective up to 40% of the time.
And when it does work, SRP reduces pocket depths
by a little over 1mm on average.
SRP is topical. It does nothing to address the
systemic nature of periodontitis.
Antibiotics help, but they are temporary and
ineffective in dealing with long term recurrences.
Surgery may be effective as a last resort, but it is
painful and expensive.
New Adjunctive Therapy:
Up to 3 times the PD reduction of SRP alone
Dramatic reduction in Bleeding On Probing
Substantial Gingival Index improvement
Results in about 30 days
Works systemically to support the body’s
natural immune system. Additional health
benefits.
This new treatment protocol is supported by some of the latest scientific
literature; so recent, in fact, that you may not have heard about it.
What research is there that has linked
antioxidants, free radicals, and
periodontitis?
Over 200 studies and clinical trials have clearly
established the close relationship between
antioxidants, free radicals and periodontal
disease. No known studies have been found that
contradict findings.
Studies conducted around the world over the
past 10 years
Renowned institutions, university dental and
medical schools, and private industry
The largest research effort to
date on this subject…
“Using data collected from over 9,862 subjects, Dr. Grossi’s
team examined serum levels of antioxidant nutrients and
their relationship to periodontal disease. Results showed
that selenium has the strongest association with gum
disease, with low levels increasing the risk by 13-fold. Low
levels of vitamins A and C, a-carotene, and b-crytoxanathin
also increased the risk.”
Article published Summer 1999
University of Buffalo
Archived at www.research.buffalo.edu
The link is confirmed for the
first time in 1999.
“Oral biologists from the University of Buffalo’s School of
Dental Medicine have shown for the first time that a diet low
in antioxidant vitamins can increase the risk of developing
gum disease. The findings have implications beyond gum
disease, since bacteria from gum infections have been
shown to play a role in heart disease, lung disease, and
diabetes, in addition to destroying gum tissue and bone.”
Article published Summer 1999
University of Buffalo
Archived at www.research.buffalo.edu
Low antioxidant levels are a risk
factor for perio disease
“What is clear is that low levels of most antioxidants are a
risk factor for periodontal disease and infection. Free
radicals are released as a result of bacteria clearance and
killing. Periodontal tissue depends on natural antioxidants
to overcome this oxidative stress and maintain
homeostasis. When antioxidants are depleted, the ability of
gum tissue to overcome oxidative stress, maintain normal
tissue, and control the bacterial damage appears to be
compromised.”
Sara Grossi, DDS
Senior Research Scientist
University of Buffalo
School of Dentistry and Medicine
People with periodontitis have
low antioxidant levels
“People with chronic periodontitis
have low levels of the protective
antioxidant glutathione, reported
researchers in the December 2002
issue of Molecular Pathology.”
“Researchers concluded that
glutathione might be beneficial when
used as a supplement to help
prevent chronic periodontitis and
might be able to assist in the healing
process.”
JADA, Vol. 134, January 2003
Free radicals can destroy
perio tissues and facilitate
bone resorption
“In aggressive and chronic forms of periodontitis, the
predominant inflammatory cells within the connective
tissues appear to be functionally activated and exhibit
increased production of free radicals. These molecules are
capable of inducing periodontal tissue destruction, and are
associated with osteoclastic bone resorption.”
Professor I L C Chapple
Unit of Periodontology
School of Dentistry
University of Birmingham
Low antioxidant levels are
both local and systemic
“This is the first reported investigation of possible
differences in GCF antioxidant capacity between
periodontal health and disease. The results from this
cross sectional study show that local, GCF total
antioxidant capacity is significantly decreased in patients
with periodontal disease. Furthermore, this local decrease
was reflected systemically by lower mean antioxidant
capacity in plasma from patients with periodontitis.”
Professor I L C Chapple
Unit of Periodontology
School of Dentistry
University of Birmingham
Antioxidants Supplements
Produce Dramatic Results
A 60-day, double-blind clinical study conducted at Loma
Linda University in 2000 gave antioxidant vitamin
supplements to subjects with various levels of periodontitis.
After just 30 days, the actual pocket depth (PD) reduction was:
Baseline PD PD Reduction Percentage
4mm .934 23.3%
5mm 1.705 34.1%
6mm 2.807 46.8%
7mm 3.125 44.6%
Bleeding virtually stopped.
Gingival Index improved markedly.
Let’s Review the Science:
Periodontal disease is a systemic disease that manifests
in the oral cavity.
Periodontal disease has now been linked to oral cancer,
heart disease, stroke, lung infections, pre-term and low
birth weight babies, osteoporosis, and other chronic
diseases.
Free radicals play an important destructive role in the
development and progress of periodontitis
Antioxidants neutralize free radicals in body tissues
Patients with periodontitis tend to have lower
antioxidant capacity – both locally and systemically
Let’s Review the Science:
Patients with low levels of certain vitamins and
minerals have up to a 13-fold greater risk of
periodontitis
Antioxidant vitamin supplements that work
systemically to support the immune system may
help fight the disease and aid in the healing
process
Certain natural antioxidant compounds actually kill
the bacteria that play an important role in chronic
periodontitis
Rapid and dramatic improvements in periodontal
tissues is possible through antioxidant vitamin
supplementation
How does
antioxidant
supplementation
compare with
antibiotic therapy?
Locally Applied Antibiotics
Arestin is a tetracycline derivative antibiotic
product with a 90% market share for locally
applied antibiotic (LAA) treatment of
periodontal disease.
It does not work systemically.
Temporary effect (14-28 days)
Typical patient cost is $25 to $30 per pocket.
Multiple treatments per site may be necessary.
Antioxidants or Antibiotics?
Mean Pocket Reduction (mm) over 9-month clinical trial
Baseline PD >5mm >6mm >7mm
SRP alone 1.08 1.05 0.98
SRP + Arestin 1.32 1.46 1.99
Antibiotic Impact 0.24mm 0.41mm 1.01mm
Actual Pocket Reduction (mm) in first 30 days of clinical trial
Antioxidants
w/out SRP 1.71mm 2.81mm 3.1mm
% Increase vs.
SRP alone 58.3% 167.6% 216.3%
Data compiled from February 2003 issue of Compendium, a peer-reviewed dental
industry journal, and Loma Linda University clinical trial press release dated April
2001.
Antioxidants or Antibiotics?
Side-by-side Comparison
Antibiotics Antioxidants
Reported Time Period 9 months 30 days
SRP 1 time None
PD reduction (>5mm) 1.32mm 1.71mm
Percentage over SRP alone 22.2% 58.3%
PD reduction (>6mm) 1.46mm 2.81mm
Percentage over SRP alone 35.2% 167.6%
Mean no. of sites treated / pat. 30.7 (3x) ALL
Total cost of treatment $2,303 + SRP $50-75
Data compiled from February 2003 issue of Compendium, a peer-reviewed dental
industry journal, Loma Linda University clinical trial press release dated April 2001,
and other sources.
So what should you do?
“More than 90% of systemic
diseases reveal signs and
symptoms in the mouth. Most
patients see their dentist on a
regular basis more frequently
than they do their physician.
We are in a unique position to
help our patients. Our mission
as general dentists is no longer
merely to wipe out dental decay
but to correct diseases in the
mouth so that the patient’s
overall health also benefits.”
David A. Tecosky, DMD,
MAGD
General Dentistry, a peer-reviewed Journal of the AGD, Dec. 2002
Recommended
new clinical protocol:
For all patients with gingivitis, bleeding
gums, bone loss, and early to advanced
chronic periodontitis:
As an adjunctive therapy to be used with SRP,
immediately prescribe a pharmaceutical-grade
antioxidant supplement with clinically determined
proper ratios of vitamins, minerals, bioflavonoids,
and a full complement of antioxidant compounds
backed by actual scientific clinical studies.
The clinical studies supporting this product
should verify the product’s ability to raise
antioxidant capacity levels and to reduce lipid
peroxidation.
The only product
clinically proven to
raise antioxidant
levels:
LifePak TM
Why LifePak ? TM
LifePak is the ONLY multi-vitamin supplement of
TM
it’s kind to have 2 double-blind, placebo
controlled, clinical trials that show clinically
significant improvements in antioxidant capacity
and lipid peroxidation.
LifePak is the #1 rated comprehensive
TM
antioxidant vitamin supplement by the industry
watchdog group, Supplement Watch.
(www.supplementwatch.com)
LifePak is the #1 selling antioxidant vitamin
TM
supplement in the world (global basis)
The science behind
TM
LifePak
The first multi-vitamin mineral supplement to
show antioxidant and cardiovascular benefits in
double-blind studies
424 scientific studies cited in LifePak
TM
Scientific Product Review for Healthcare
Professionals
LifePak contains more than 40 antioxidant
TM
vitamins, minerals, flavonoids, carotenoids, and
other compounds clinically proven to scavenge
free radicals
The science behind LifePak TM
65 1200
Placebo (means +/- SD) p < 0.001 Placebo (means +/- SD)
60 LifePak 1000 LifePak
p < 0.001
LDL Protection b-Carotene
55
800
50
50.9 600 716
45
43.4 400
40 42.1 42
331 335
35 200 299
30 0
Baseline Endpoint Baseline Endpoint
LifePak improved antioxidant 8
Placebo
7 p < 0.001
status and protection of LDL 6
LifePak
(means +/- SD)
6.248
against free radical damage. 5
4
Vitamin E
Smidt CR, Seidehamel RJ, Devaraj S, Jialal I.
3 3.429 3.305 3.477
The Effects of a Nutritionally Complete Dietary
Supplement (LifePak®) on Antioxidant Status 2
and LDL-Oxidation in Healthy Non-Smokers. 1
FASEB Journal Vol.13 No.4, p.A546, March 0
1999. Baseline Endpoint
Why LifePak ? TM
LifePak costs about $60
TM
per month when purchased
on the company’s automatic
delivery rewards program
(ADR). 20-30% rebate for
ADR customers.
Special formulations of LifePak for Women,
TM
LifePak Prime for adults over 40, and Pre-Natal
TM
LifePak are also available.
TM
LifePak works.
TM
You can prove
it yourself.
LifePak augments the
entire antioxidant
defense system.
The effect can easily be
demonstrated using the
BioPhotonic Scanner.
Clinical Study Results
Chart shows increase in Body Defense Scores
as measured by the BioPhotonic Scanner for
40000
people taking LifePak daily.
35000
30000 32175
28924
25000 25991
20000
18828
15000 p < 0.001 p < 0.01 p = 0.23
10000
5000
0
0 4 8 12
Time (Weeks)
The BioPhotonic Scanner is
a practice builder!
The scanner is high tech. It is unique. Patients
will talk about it. It sets you apart from all the rest.
The scanner provides patients with a valuable
insight into their personal antioxidant network
status.
The desire to measure personal progress keeps
patients coming back to your practice.
The ability to monitor antioxidant status keeps
them on the product long-term.
Why Pharmanex?
ONLY Pharmanex has the BioPhotonic Scanner
that can actually measure the levels of certain
antioxidants in human tissue.
By obtaining a Body Defense Score (BDS) using
the scanner, a consumer can readily discover
whether or not his / her immune system is
working optimally, and if their supplements are
actually doing anything.
Pharmanex was the only supplement
company to qualify as an official sponsor
of the US Olympic Team. All Pharmanex
products had to pass rigorous tests by an
independent lab before acceptance.
Why Pharmanex?
Pharmanex offers a 100% Money Back
GUARANTEE that LifePak will increase the
antioxidant capacity of every individual who takes
the product for at least 60 days.
Pharmanex is part of a publicly traded billion
dollar company that is profitable, carries a 5A1
Dunn & Bradstreet rating.
Pharmanex offers many other high quality
nutritional supplements in addition to LifePak.
Why Pharmanex?
All Pharmanex formulations are based on solid
scientific research and clinical trials.
Pharmanex employs over 79 PhD’s who perform
ongoing research and clinical trials.
The Scientific Advisory Board at Pharmanex
includes some of the world’s leading experts in
the fields of nutrition, biology, medicine, and
antioxidants.
What we know:
SRP + Antioxidants fight the disease both
locally and systemically
Patients may receive other health benefits
from taking antioxidant supplements
Antioxidant supplementation is safe, cost
effective, and supported by a growing body of
research.
Patients in clinical trials with quality
antioxidants have demonstrated remarkable,
and possibly unprecedented periodontal
status improvement.
Why you should prescribe
antioxidants…
Because your patients deserve the best
treatment options clinically available.
Because the scientific literature supports the
efficacy of antioxidant therapy protocols as
effective adjunctive treatment modalities.
Because SRP alone is ineffective up to 40% of
the time. When it does work, it provides
marginal clinical improvement. Topical only.
Because antioxidant supplementation works
with SRP to battle periodontitis from within.
Why you should prescribe
antioxidants…
Because LAA therapy does not address the
systemic nature of periodontal disease.
Because LAA treatment is expensive,
temporary, and marginally effective relative to
antioxidants.
And, because your practice can make money
by doing the right thing for your patients.
Generate passive, leveraged income
How much money can there be in
prescribing antioxidants?
Primary Assumptions:
Patient scans / day: 4
Acceptance Rate: 75%
ADR Average Order: $62.70 (LP +Tegreen)
Annual Attrition Rate: 50%
Annualized NET in mo. 12: $111,638
Staff Bonus @ 20%: $22,328
Practice NET PROFIT: $89,310
Additional assumptions available upon request. Each practice results will
vary according to individual efforts and promotion abilities.
Wait. It gets better . . .
This income stream can continue to grow each
year as more and more new and existing patients
get on the LifePak program.
Furthermore . . . MINIMAL Doctor time is required.
This program works almost entirely through your
hygiene dept.
And best of all . . . That income can continue on
into your retirement. Imagine that. Being paid for
years into the future because you did the right
thing for your patients today.
Each practice results will vary according to individual efforts and promotion abilities.
Review
Biophotonic Scanner = Proven Science
Capture fastest growing economic trends
Third party validated products from solid
company
Direct Dental application – set yourself apart
Leveraged Income stream