Program Director/Principal Investigator (Last, First, Middle):
BIOGRAPHICAL SKETCH
NAME POSITION TITLE
Henry L. Galan, MD Professor & Chief of Maternal-Fetal Medicine
eRA COMMONS USER NAME (credential, e.g., agency login)
Obstetrics and Gynecology
University of Colorado at Denver Health Sciences Center
GALAN.H
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION MM/YY FIELD OF STUDY
(if applicable)
University of Texas – Austin, TX BA 1985 Biology
Texas A & M –College Station TX MD 1989 Medicine
Scott & White Hospital – Temple TX Residency 1993 OB/GYN
University of Texas Health Sci Ctr. – Houston, TX Fellowship 1995 Maternal-Fetal Medicine
University of Colorado Denver, CO Rsch Fellow 1997 Perinatal research
A. Personal Statement
My laboratory is currently focused on placental vascular development and nutrient transfer in both human and ovine
pregnancy with focus on physiologic and molecular mechanisms underlying normal fetal growth and IUGR with funding
from both NIH and non-NIH sources. I have mentored both MFM and PhD fellows and faculty with a recent K99 award for
a mentee, Dr. Juan Arroyo I have a broad background in biology and physiology with early career mentored research
funding that included a T32, AAOGF and WRHR grant providing me with the needed training and expertise to complete
proposed research.
B. Positions and Honors
Positions:
1992-93: Clinical Instructor, Department of OB/GYN, Scott & White Hospital, TAMU-HSC, Temple, TX
1993-95: Clinical Instructor, Department of OB/GYN, Univ of Texas, Houston, TX
1995-97: Clinical Instructor, Department of OB/GYN, Univ of Colorado Health Sciences Center, Denver, CO
1997 – 2004: Assistant Professor, Department of OB/GYN, Division of MFM, UCDSOM, Denver, CO
2000 – Present: Director of the Maternal-Fetal Medicine Fellowship, UCDSOM, Denver, CO
2004 2009: Associate Professor & MFM Section Chief, Department of OB/GYN, UCDSOM, Denver, CO
2009-Present: Professor& MFM Section Chief, Department of OB/GYN, UCDSOM, Aurora, CO
Honors:
1993: AOA Medical Honor Society
1995, 1997, 2002: Stuart Gottesfeld Resident Teaching Award
1997: NIH Young Investigator invitation to the1997-98 Annual Meeting of the Perinatal Research Society.
1997-2000: Burroughs Wellcome and American Assoc. Obstet Gynecol. Foundation Research award.
2000-2003: Colorado NIH Women’s Reproductive Health Research Award
2002: APGO award for excellence in teaching.
2004: CREOG National Faculty Award for Excellence in Resident Education
Other Experience and Professional Memberships:
Active Member: ACOG, SGi, SMFM, PRS, AIUM, Colorado Gynecologic Obstetrical Society.
2004-present Chair, UCHSC Perinatal Database Committee & PRA Search Committee
2004-present Platte River Perinatal Center, Board of Directors member, UCHSC
2004-present Women’s Reproductive Health Research Scholar Program – UCDHSC Advisory Committee
2008-present Member, Centura Health System Perinatal Safety Task Force Committee
2007-present Medical Director of Labor & Delivery, University of Colorado Hospital
2006-present Medical Director of Perinatology, Parker Adventist Hospital
2003-present Colorado Department of Public Health; Maternal Morbidity and Mortality Committee t
2000 NICHD; Workshop on Amniotic Fluid (J Matern Fetal Med 2001;10(1):2-19)
2006 NIH Pregnancy and Neonatology Study Section – Ad Hoc reviewer
2008 NIH Pregnancy and Neonatology Study Section – Ad Hoc reviewer
2006 NICHD; Workshop on Prenatal Imaging (presented uterine artery Doppler and pregnancy outcomes)
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Program Director/Principal Investigator (Last, First, Middle):
2010 NICHD; Reviewer of RFP on “The National Standard for Normal Fetal Growth”
C. Selected Peer-reviewed Publications
1. Galan HL, Hussey M, Chung M, Hobbins JC, Battaglia FC, Meschia G. Doppler velocimetry of growth retarded
fetuses in an ovine model of placental insufficiency. Am J Obstet Gynecol 178:451-6, 1998. PMID: 9539507
2. Galan HL, Rigano S, Chyu J, et al. Comparison of low and high altitude Doppler velocimetry in the peripheral and
central circulations of normal fetuses. Am J Obst Gyn 183:1158-61, 2000. PMID: 11084558
3. Ferrazzi E, Rigano S, Barbera A, Giovannini N, Vinci M, Galan HL, Battaglia FC. Umbilical vein blood flow Doppler
measurements in growth restricted fetuses. Ultrasound Obstet Gynecol 16:432-438, 2000. PMID: 11169327
4. Galan HL, Regnault TRH, Le Cras TD, Tyson RW, Anthony RV, Wilkening RB, Abman SH. Cotyledon and binucleate
cell eNOS expression in an ovine model of IUGR. J Appl Physiol 90:2420-2426, 2001. PMID: 11356809
5. Ferrazzi E, Bellotti M, Bozzo M, Rigano S, Pardi G, Battaglia F, Galan HL. The temporal sequence of changes in
fetal velocimetry indices for growth restricted fetuses. Ultrasound Obstet Gynecol 19:140-46, 2002. PMID: 11876805
6. Regnault TRH, Orbus RJ, de Brijer B, Davidsen ML, Limesand S, Galan HL, Wilkening RB, Anthony RV. Placental
expression of VEGF, PIGF and their receptors in a model of placental insufficiency – intrauterine growth restriction
(PI-IUGR). Placenta 23: 132-144, 2001. PMID: 11945079
7. Regnault TRH, de Brijer B, Galan HL, Davidsen ML, Trembler KA, Battaglia FC, Wilkening RB, Anthony RV. The
relationship between transplacental oxygenation diffusion and placental expression of PlGF, VEGF and their
receptors in a placental insufficiency model of FGR. J Physiol 550.2:641-56, 2003. PMID: 12740423 [
8. Galan HL, Rigano S, Hobbins J, Ferrazzi E, Anthony RV, Wilkening R, Regnault TRH. Hypertension and abnormal
Doppler velocimetry in an ovine model of IUGR. Am J Obstet Gynecol 192:272-9, 2005.
9. Arroyo JA, Anthony RV, Parker RV and Galan HL. Differential Expression of Placental and Vascular Endothelial Nitric
Oxide Synthase (eNOS) in an Ovine Model of Fetal Growth Restriction. Am J Ob Gynecol 195(3):771-7, 2006.
10. Ziebell BT, Arroyo JA, Anthony RV, Parker TA, Regnault TRH, Galan HL. Ontogeny of endothelial nitric oxide
synthase mRNA and in an Ovine IUGR Model. Am J Obstet Gynecol;:420:e1-e5, 2007. PMID: 17904986
11. Regnault TRH, de Vrijer B, Galan HL, Wilkening RB, Battaglia FC, and Meschia G. Development and mechanisms of
fetal hypoxia in severe fetal growth restriction. Placenta Jul;28(7):714-23, 2007. PMID: 16962658
12. Baschat AA, Cosmi E, Bilardo CM, Wolf A, Berg Christoph, Rigano S, Germer U, Moyano D, Turan S, Hartung J,
Bhide A, Muller T, Nicolaides KH, Gembruch U, Ferrazzi, Hecher K, Galan HL, Harman CR. Determinants of neonatal
outcome in early onset placental insufficiency. Obstet Gynecol 109:253-61, 2007. PMID: 17267821
13. Arroyo JA, Anthony RV, Galan HL. Decreased X-linked Inhibitor of Apoptosis Protein (XIAP) in an Ovine Model of
Fetal Growth Restriction. Am J Obstet Gynecol. Am J Obstet Gynecol (Jul) 199(1):80.e1-8, 2008. PMID: 18295176
14. Galan HL, Marconi AM, Paolini CL, Cheung A, Battaglia FC. The Transplacental transport essential amino acids in
uncomplicated human pregnancies. Am J Obstet Gynecol (Jan) 200(1):91, 2009. PMID: 19019331
15. Rigano S, Ferrazzi E, Boito S, Pennati G, Padoan A, Galan HL. Blood flow volume of uterine arteries in human
pregnancies determined by a novel combined use of 3D and bi-dimensional imaging, angio-Doppler and fluid-dynamic
modeling. Placenta 2010 Jan;31(1):37-43. PMID: 19945159
D. Research Support
Ongoing Research Support:
1 R01 DK 078645 (PI: Linda A. Barbour, MD, MSPH) 3/13/2010-3/14/2015
Source: NIH Title: Regulation of Maternal Fuel Supply and Neonatal Adiposity
Role: Co-investigator (8% FTE). My role in this project involves clinical assessment of fetal subcutaneous (fat) and lean
mass accretion with 2D and 3D ultrasound which is to be correlated with neonatal DEXA scans of fetal fat stores.
1 R01 DK 076648-01A2 (PI: Dana Dabelea, MD, PhD) 8/1/2009 -7/31/2014
Role:
Source: NIH Title: Exploring the Fuel-Mediated Programming of Neonatal Growth
Role: Co-investigator (3% FTE). My role in this project involves the medical oversight of participants, participation in
the interpretation of results, review and editing of reports and publications.
1 K99 HD55054-01A2 (PI: Juan Arroyo, PhD) 6/1/2009-5/31/2009
Source NIH Title: Apoptosis in an ovine model of intrauterine growth restriction (IUGR)
Role: Mentor for first two years of the K99 award with Dr. Arroyo assuming independence in years 3-5 and continued
participation in the interpretation of results, review and editing of reports and publications.
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Program Director/Principal Investigator (Last, First, Middle):
Completed Research Support
1 R01 HL71990-01A1 (PI: Henry L. Galan, MD) 9/1/03-8/31/07 (1-year no cost extension)
Source: NIH Title: Fetal and Neonatal Hemodynamics in IUGR Pregnancies
This project investigates mechanisms of blood flow control in an ovine model of IUGR
K12HD01271 Women's Reproductive Health Research Award 7/1/00-8/31/03
NIH Scholar’s Award
The purpose of this grant is to investigate nitric oxide synthase mRNA expression in the ovine placenta involving the
isolation of the eNOS gene isolation in the sheep.
2-RO1HD34837-06. (PI: Frederick C Battaglia, MD; 2/02 – 2/07; (1-year no cost extension)
Role: Co-investigator 2/02-2/05; PI 2/05-7; no cost extension
Source: NIH Title: Fetal Velocimetry & Amino Acid Transport in Pregnancy
This project involves clinical studies of amino acid and carbohydrate transport in pregnant women. Dr. Galan’s efforts are
geared at the management of the obstetrical components of the protocols. He will become PI for this project at 30% effort
in year 3 of the grant.
RO1 HD41505 (PI: Randall B. Wilkening, MD) 07/02 – 06/07; (1-yr no cost extension)
Role: Co-Investigator. Source: NIH Title: Fetoplacental amino acid metabolism in IUGR pregnancies
Dr. Galan’s research efforts in this grant are to assess fetal growth in these projects using an ovine model of IUGR.
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