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					Data Set   gi accession no.   Short name
RBR-       gi|10047279        KIAA1602 protein
RBR+       gi|10242373        DNA replication licensing factor MCM7
RBR-       gi|1065361         Chain A, Human Adp-Ribosylation Factor 1 Complexed With Gdp, Full Length Non-Myristo
RBR+       gi|109016328       peptidoglycan recognition protein 3-like isoform 1
RBR-       gi|109086164       steroidogenic acute regulatory protein, mitochondrial isoform 3
RBR-       gi|109086730       hypothetical protein LOC697620
RBR+       gi|109087141       Kruppel-like factor 10 isoform 2
RBR-       gi|109088173       DNA/RNA-binding protein KIN17-like isoform 2
RBR+       gi|109094060       protein EAN57-like
RBR+       gi|109103395       uncharacterized protein C2orf78
RBR-       gi|109110028       ubiquitin carboxyl-terminal hydrolase 20-like
RBR-       gi|109122103       RNA polymerase II transcription factor SIII subunit A2
RBR-       gi|109481200       hypothetical protein
RBR-       gi|111836          inositol 1,4,5-triphosphate receptor, long splice form - rat (fragment)
RBR+       gi|114568293       glutamine synthetase isoform 1
RBR+       gi|114572452       hypothetical protein
RBR-       gi|114593156       hypothetical protein
RBR+       gi|114595580       similar to cytochrome P450
RBR-       gi|114609317       similar to D53
RBR+       gi|114621345       fibrocystin L
RBR-       gi|114629321       hypothetical protein
RBR+       gi|114666215       sex hormone-binding globulin isoform 6
RBR+       gi|114687965       hypothetical protein
RBR-       gi|114691581       similar to pseudoautosomal GTP-binding protein-like protein variant, partial
RBR-       gi|114691830       hypothetical protein
RBR-       gi|119024999       phosphoinositol 3-phosphate-binding protein 3
RBR-       gi|119582517       hCG1980568
RBR-       gi|119594673       hCG1652096, isoform CRA_b
RBR-       gi|119599176       hCG1807404
RBR-       gi|119599887       hCG2022589
RBR+       gi|119600494       hCG1642363, isoform CRA_b
RBR-       gi|119600781       hCG1650573, isoform CRA_a
RBR-       gi|119608294       hCG2021613
RBR-       gi|119612312       hCG2008737
RBR+       gi|119614501       hCG2043259
RBR-       gi|119619151       hCG1790520
RBR-       gi|119627030       hCG2041820
RBR-       gi|119877633       hypothetical protein
RBR+       gi|119900578       piwi like homolog 2-like, partial
RBR-       gi|119910211       dipeptidase 2
RBR-       gi|12052774        hypothetical protein
RBR-       gi|123233024       novel protein
RBR+       gi|123239894       serine/threonine kinase 4
RBR-   gi|124001866   MYOD1
RBR-   gi|126294328   hypothetical protein
RBR+   gi|126303648   similar to HSRG1849
RBR-   gi|126304349   similar to phospholipase C, beta 4
RBR-   gi|126305690   similar to carnitine palmitoyltransferase II
RBR-   gi|126305758   similar to transferrin receptor 2
RBR-   gi|126306346   similar to translocated promoter region (to activated MET oncogene),
RBR-   gi|126308190   similar to GSDML protein
RBR-   gi|126308771   similar to ICT1 protein
RBR+   gi|126309748   similar to butyrophilin-like 8
RBR+   gi|126310162   similar to LOC560387 protein
RBR+   gi|126311138   similar to phosphoglycerate kinase
RBR-   gi|126311376   similar to acidic calponin
RBR-   gi|126316178   similar to peptidylglycine alpha-amidating monooxygenase isoform a, preproprotein
RBR-   gi|126324467   similar to RBM19 protein
RBR-   gi|126324995   similar to MORC family CW-type zinc finger protein 2 (Zinc finger CW-type coiled-coil dom
RBR-   gi|126331695   similar to ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase), isoform 1
RBR-   gi|126332762   similar to cOR4S3 olfactory receptor family 4 subfamily S-like
RBR+   gi|126334034   hypothetical protein
RBR+   gi|126335208   similar to choline transporter-like protein 1, splice
RBR-   gi|126335823   hypothetical protein
RBR-   gi|126345116   similar to TRIM5alpha, partial
RBR+   gi|12751452    PDZ domain-containing protein AIPC
RBR+   gi|12805201    CDNA sequence BC002059
RBR+   gi|12840207    unnamed protein product
RBR+   gi|12845693    unnamed protein product
RBR-   gi|12846064    unnamed protein product
RBR-   gi|12851862    unnamed protein product
RBR-   gi|12853264    unnamed protein product
RBR+   gi|12853685    unnamed protein product
RBR+   gi|12853956    unnamed protein product
RBR-   gi|12859782    unnamed protein product
RBR-   gi|13562118    low-density lipoprotein receptor-related protein 2 precursor
RBR-   gi|1374879     nuclear hormone receptor
RBR-   gi|148228679   raftlin family member 2
RBR+   gi|148664711   mCG1031578
RBR-   gi|148672299   mCG1027690
RBR+   gi|148679450   nuclear import 7 homolog (S. cerevisiae), isoform CRA_b
RBR-   gi|148684097   mCG13235
RBR-   gi|148690504   mCG140594
RBR-   gi|148696286   cytoskeleton associated protein 2-like, isoform CRA_a
RBR-   gi|148698174   mCG16273
RBR-   gi|148705765   mCG65590
RBR+   gi|148708716   mCG62823
RBR-   gi|149017603   neonatal submandibular gland protein C, isoform CRA_a
RBR+   gi|149038447   similar to FKSG26 protein (predicted), isoform CRA_a
RBR+   gi|149039245   rCG45882
RBR+   gi|149040858   AT hook containing transcription factor 1 (predicted)
RBR-   gi|149042882   rCG32230
RBR-   gi|149049092   solute carrier organic anion transporter family, member 1b2, isoform CRA_b
RBR-   gi|149057287   similar to NADP+-specific isocitrate dehydrogenase, isoform CRA_d
RBR-   gi|149061067   similar to hypothetical protein (predicted), isoform CRA_a
RBR-   gi|149068601   rCG40373
RBR-   gi|149409778   similar to DNA polymerase iota
RBR+   gi|149412521   similar to KIAA0715 protein
RBR-   gi|149412795   similar to Cadherin 9, type 2 (T1-cadherin)
RBR-   gi|149412803   similar to transcription factor forkhead-like 7
RBR+   gi|149433828   similar to beta-adrenergic kinase 2, partial
RBR-   gi|149445026   hypothetical protein, partial
RBR-   gi|149471617   similar to SPEN homolog, transcriptional regulator, partial
RBR-   gi|149485854   similar to Phospholipase C, delta 1, partial
RBR-   gi|149523405   similar to dopamine receptor interacting protein
RBR-   gi|149527720   similar to potassium voltage-gated channel, shaker-related subfamily, member 6, partial
RBR-   gi|149570642   similar to V1R pheromone receptor-like protein, partial
RBR-   gi|149592775   similar to ankyrin-repeat and fibronectin type III domain containing 1
RBR-   gi|149609232   similar to Asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferas
RBR-   gi|149633795   hypothetical protein
RBR+   gi|149634564   similar to family with sequence similarity 26, member C
RBR-   gi|149637067   similar to nuclear factor RIP140
RBR-   gi|149638002   similar to nephrocystin-6
RBR-   gi|149638077   similar to leucine-rich repeat transmembrane neuronal 4 protein
RBR+   gi|149638178   similar to Rad50
RBR-   gi|149701835   similar to Tigger transposable element-derived protein 2
RBR-   gi|149720134   similar to glutathione S-transferase, theta 4
RBR+   gi|149722228   DEAH (Asp-Glu-Ala-His) box polypeptide 34
RBR-   gi|149728726   similar to Uncharacterized protein C3orf23
RBR+   gi|149731066   similar to Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein me
RBR+   gi|149757935   similar to pleckstrin homology domain containing, family A (phosphoinositide binding speci
RBR-   gi|157504286   MHC class I antigen
RBR+   gi|157818737   probable histone-lysine N-methyltransferase ASH1L
RBR-   gi|157818807   epididymal-specific lipocalin-9
RBR+   gi|157821507   PHD finger protein 20
RBR-   gi|159162145   Chain A, Rotamer Strain As A Determinant Of Protein Structural Specificity
RBR-   gi|161016927   tolerance-associated gene 1
RBR-   gi|16716541    vomeronasal type-1 receptor 46
RBR+   gi|170649651   coagulation factor VIII precursor (predicted)
RBR-   gi|180946      cytochrome c oxidase subunit VIa
RBR+   gi|1865644     pancreatic lipase
RBR-   gi|18676660    FLJ00229 protein
RBR-   gi|187960160   BR serine/threonine-protein kinase 1
RBR-   gi|190360663   FYVE and coiled-coil domain-containing protein 1
RBR+   gi|1932712     prostate carcinoma tumor antigen
RBR-   gi|193808      tyrosine phosphatase
RBR-   gi|194216523   similar to notum pectinacetylesterase homolog
RBR-   gi|194216820   similar to G patch domain containing 8
RBR-   gi|194217363   flotillin 2
RBR-   gi|194217624   similar to tumor necrosis factor-like weak inducer of apoptosis
RBR-   gi|194218540   similar to transmembrane protein 134
RBR-   gi|194219339   similar to Uncharacterized protein C16orf59
RBR+   gi|194222561   zinc finger, B-box domain containing
RBR+   gi|194226455   similar to Werner syndrome ATP-dependent helicase
RBR+   gi|194227434   similar to Synaptotagmin-2 (Synaptotagmin II) (SytII)
RBR-   gi|194228068   similar to cylicin
RBR+   gi|194373989   unnamed protein product
RBR-   gi|194667596   prematurely terminated mRNA decay factor-like
RBR+   gi|197102480   spliceosome RNA helicase BAT1
RBR-   gi|20043249    TPA_exp: pantothenate kinase 4 putative variant; PANK4p
RBR-   gi|20071759    Unknown (protein for MGC:36892)
RBR+   gi|20072584    V-set and transmembrane domain containing 2A
RBR-   gi|2119626     cadherin 8 - human
RBR-   gi|21758490    unnamed protein product
RBR+   gi|219883508   signaling lymphocyte activation molecule
RBR-   gi|221044814   unnamed protein product
RBR-   gi|22902303    Leucine rich repeat containing 8D
RBR+   gi|23956358    leucine-rich repeat-containing protein 66
RBR-   gi|247424213   immunoglobulin heavy chain variable region
RBR-   gi|26324736    unnamed protein product
RBR+   gi|26329097    unnamed protein product
RBR-   gi|26333111    unnamed protein product
RBR-   gi|26334583    unnamed protein product
RBR-   gi|26335611    unnamed protein product
RBR-   gi|26336067    unnamed protein product
RBR+   gi|26341796    unnamed protein product
RBR+   gi|26348877    unnamed protein product
RBR-   gi|26351529    unnamed protein product
RBR-   gi|2766531     inositol polyphosphate 5-phosphatase II splice variant
RBR-   gi|2773081     sarcoplasmic reticulum Ca2+-ATPase
RBR+   gi|27806021    calcium-binding and coiled-coil domain-containing protein 2
RBR+   gi|27806629    dimethylaniline monooxygenase
RBR-   gi|27806691    lysosomal-trafficking regulator
RBR-   gi|281306803   myomesin 2
RBR-   gi|281337540   hypothetical protein PANDA_017838
RBR+   gi|281337739   hypothetical protein PANDA_003017
RBR-   gi|281337747   hypothetical protein PANDA_007621
RBR+   gi|281341744   hypothetical protein PANDA_015212
RBR-   gi|281350292   hypothetical protein PANDA_004321
RBR-   gi|281351123   hypothetical protein PANDA_002477
RBR+   gi|281352535   hypothetical protein PANDA_013243
RBR-   gi|281353154   hypothetical protein PANDA_003347
RBR-   gi|28192984    utrophin short isoform, Up109
RBR-   gi|285398425   vomeronasal type-1 receptor A16
RBR-   gi|291387820   EF-hand calcium binding domain 9-like
RBR-   gi|291390730   ATP-binding cassette transporter sub-family A member 15-like
RBR-   gi|291391468   Nck-associated protein 5
RBR-   gi|291392051   WD repeat domain 12 protein
RBR-   gi|291393744   hypothetical protein
RBR+   gi|291399633   asteroid homolog 1
RBR-   gi|291399673   oxidoreductase NAD-binding domain containing 1
RBR+   gi|291401210   KIAA1816 protein-like
RBR-   gi|291402337   hypothetical protein
RBR+   gi|291403565   homeodomain leucine zipper protein
RBR+   gi|291404384   lipase N
RBR+   gi|291408564   fragile X mental retardation 2
RBR-   gi|291409011   zinc finger protein 84-like
RBR-   gi|291410965   serine/threonine kinase 30-like
RBR-   gi|291412186   inositol 1,4,5-trisphosphate 3-kinase C
RBR-   gi|291414007   olfactory receptor, family 7, subfamily A, member 17-like
RBR+   gi|291414037   tubulin tyrosine ligase-like family, member 8-like
RBR-   gi|291416435   gasdermin D-like
RBR-   gi|293342260   DAZ interacting protein 1 isoform 2
RBR-   gi|293344733   KIAA1345 protein-like
RBR-   gi|293346231   spectrin, beta, non-erythrocytic 5
RBR-   gi|293347747   rCG63019-like
RBR+   gi|296190139   ubiquitin-associated protein 2
RBR-   gi|296192613   uncharacterized protein C5orf52-like
RBR+   gi|296197418   transmembrane protein 14D-like
RBR-   gi|296204017   zinc finger protein 710-like
RBR-   gi|296208190   LOW QUALITY PROTEIN: WD repeat-containing protein 78-like
RBR+   gi|296226301   pleckstrin homology-like domain family B member 2
RBR-   gi|296229206   nestin
RBR-   gi|297269594   scavenger mRNA-decapping enzyme DcpS-like
RBR-   gi|297276705   hypothetical protein LOC100429770
RBR+   gi|297278903   uncharacterized protein C1orf141-like isoform 2
RBR-   gi|297291023   LOW QUALITY PROTEIN: fibrocystin-like
RBR-   gi|297291239   phosphoacetylglucosamine mutase
RBR-   gi|297295313   protocadherin gamma-B2-like
RBR+   gi|297303590   ferritin heavy chain-like
RBR-   gi|297465517   neuroblastoma breakpoint family, member 6
RBR+   gi|297468086   olfactory receptor, family 7, subfamily A, member 17-like
RBR+   gi|297475429   hypothetical protein
RBR-   gi|297492369   cancer/testis antigen family 147, member B1-like, partial
RBR-   gi|297661948   isoleucyl-tRNA synthetase, mitochondrial-like
RBR+   gi|297662116   hypothetical protein LOC100438317
RBR+   gi|297671951   LOW QUALITY PROTEIN: calpain-7-like
RBR-   gi|297682878   oxygen-regulated protein 1-like
RBR-   gi|297693522   hypothetical protein LOC100457741
RBR-   gi|297700445   coiled-coil domain-containing protein 55-like
RBR-   gi|297707949   hypothetical protein LOC100441779
RBR+   gi|300300      CCAAT displacement protein, CDP
RBR+   gi|301771302   LOW QUALITY PROTEIN: UTP--glucose-1-phosphate uridylyltransferase-like
RBR+   gi|301775869   LOW QUALITY PROTEIN: microtubule-associated protein RP/EB family member 1-like
RBR+   gi|301777842   nephronectin-like
RBR-   gi|301784214   alpha-2Da adrenergic receptor-like
RBR-   gi|302565700   dual oxidase maturation factor 2
RBR+   gi|30348972    coiled-coil domain-containing protein 62 isoform a
RBR-   gi|307648425   microcephalin
RBR-   gi|307648431   microcephalin
RBR-   gi|308210830   collagen alpha-2(IX) chain
RBR-   gi|309263499   hypothetical protein LOC216818
RBR+   gi|309322929   apolipoprotein B
RBR-   gi|310118669   neuroblastoma breakpoint family member 20-like isoform 4
RBR+   gi|310123977   hypothetical protein LOC284804
RBR-   gi|311243931   ectonucleotide pyrophosphatase/phosphodiesterase family member 1, partial
RBR+   gi|311244608   probable E3 ubiquitin-protein ligase HERC1
RBR-   gi|311248410   hypothetical protein LOC100515009
RBR-   gi|311250716   olfactory receptor 4C11-like
RBR-   gi|311253094   structural maintenance of chromosomes protein 6-like
RBR-   gi|311255288   spermatogenesis-associated serine-rich protein 2-like
RBR-   gi|311255469   homeobox protein Hox-C13-like
RBR-   gi|311258229   cytochrome c oxidase subunit 6B2-like
RBR+   gi|311262037   hypothetical protein LOC100513026
RBR-   gi|311263869   hypothetical protein LOC100513558
RBR+   gi|311263940   ubiquitin carboxyl-terminal hydrolase 28-like
RBR-   gi|311266522   hypothetical protein LOC100511713
RBR+   gi|311268641   programmed cell death 6-interacting protein-like
RBR+   gi|311271940   BTB/POZ domain-containing protein 16-like
RBR-   gi|311276477   uncharacterized protein CXorf49-like
RBR-   gi|311277302   box C/D snoRNA protein 1-like
RBR+   gi|3133255     PGP9.5
RBR-   gi|32329380    T-cell receptor beta chain
RBR-   gi|33341704   FP852
RBR+   gi|33942118   zinc finger protein 516
RBR-   gi|34532781   unnamed protein product
RBR+   gi|34533800   unnamed protein product
RBR-   gi|37181045   smooth muscle archvillin
RBR-   gi|37360346   mKIAA1377 protein
RBR+   gi|37936017   SSXB11 protein
RBR-   gi|3850728    MICA
RBR-   gi|400217     RecName: Full=Interferon-induced guanylate-binding protein 1; AltName: Full=GTP-bindin
RBR-   gi|40786489   rho guanine nucleotide exchange factor 25
RBR-   gi|409226     brain beta spectrin
RBR+   gi|437805     Laminin Ah
RBR+   gi|4505753    phosphoglycerate mutase 1
RBR-   gi|4559318    BC273239_1
RBR-   gi|4589916    heart-type calpastatin
RBR-   gi|466391     zinc finger protein
RBR-   gi|47523152   phosphoinositide 3-kinase regulatory subunit 5
RBR+   gi|47523318   ubiquitin carboxyl-terminal hydrolase isozyme L1
RBR-   gi|48425521   Chain B, Tsg101(Uev) Domain In Complex With Ubiquitin
RBR+   gi|4885637    target of Myb protein 1 isoform 1
RBR+   gi|49258190   NCK-interacting protein with SH3 domain
RBR-   gi|5002593    LSFR3A protein
RBR-   gi|50927341   Zinc finger protein 61
RBR+   gi|50978950   aspartate beta-hydroxylase
RBR-   gi|5262712    hypothetical protein
RBR-   gi|54673782   Golga4 protein
RBR-   gi|551597     epiligrin alpha 3 subunit
RBR-   gi|57089129   similar to Protein C1orf43 (Hepatitis C virus NS5A-transactivated protein 4) (NICE-3 protei
RBR+   gi|58218966   hypothetical protein LOC339201
RBR-   gi|5916179    Msx2 interacting nuclear target protein
RBR-   gi|61553106   sulfide dehydrogenase like
RBR-   gi|62087480   promyelocytic leukemia protein isoform 11 variant
RBR-   gi|62287499   RecName: Full=Semenogelin-2; AltName: Full=Semenogelin II; Short=SGII; Flags: Precurs
RBR-   gi|62739564   Chromosome 20 open reading frame 200
RBR+   gi|62871256   immunoglobulin alpha heavy chain variable region
RBR-   gi|633050     zona pellucida 2 glycoprotein
RBR-   gi|68163477   transmembrane protein 90B
RBR-   gi|71388172   dentin matrix protein 1
RBR-   gi|71388252   dentin matrix protein 1
RBR+   gi|73946259   similar to squamous cell carcinoma antigen recognized by T cells 2
RBR-   gi|73946895   hypothetical protein XP_846678
RBR-   gi|73951182   similar to Proprotein convertase subtilisin/kexin type 6 precursor (Paired basic amino acid
RBR-   gi|73951695   similar to KIAA1199
RBR+   gi|73957808   similar to RAB, member of RAS oncogene family-like 5 (predicted)
RBR+   gi|73958855   similar to limkain b1 isoform 1 isoform 1
RBR-   gi|73960916   similar to semaphorin B isoform 2
RBR-   gi|73961846   similar to THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) isoform 3
RBR+   gi|73964993   similar to likely ortholog of mouse ubiquitin-conjugating enzyme E2-230K
RBR-   gi|73971093   similar to Protein C9orf72 homolog isoform 2
RBR-   gi|73973428   similar to Protein C6orf165 isoform 1
RBR-   gi|73979856   similar to Kinesin-like protein KIF3C isoform 7
RBR-   gi|73983780   similar to lectin, galactoside-binding, soluble, 12 (galectin 12)
RBR+   gi|73983914   hypothetical protein XP_851983
RBR-   gi|73985656   hypothetical protein XP_845566
RBR-   gi|73988400   similar to olfactory receptor Olr136
RBR+   gi|73992595   similar to serologically defined colon cancer antigen 33 like
RBR+   gi|73996409   similar to osterix
RBR+   gi|73999891   similar to Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) is
RBR-   gi|74000055   similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (Phosphoinos
RBR+   gi|74000319   similar to Erythrocyte membrane protein band 4.2 (Erythrocyte protein 4.2) (P4.2)
RBR-   gi|74005297   similar to microtubule-associated protein 2 isoform 3 isoform 2
RBR-   gi|74008463   similar to zinc finger, CCHC domain containing 12
RBR-   gi|74047736   proSAP-interacting protein 1
RBR-   gi|74139178   unnamed protein product
RBR-   gi|74214457   unnamed protein product
RBR+   gi|74217239   unnamed protein product
RBR-   gi|74711510   RecName: Full=Putative uncharacterized protein C11orf55
RBR+   gi|8132878    histone deacetylase 8
RBR+   gi|8515896    prolactin-like protein
RBR-   gi|8923565    aurora kinase A-interacting protein
RBR+   gi|90076940   unnamed protein product
RBR-   gi|929005     unnamed protein product
RBR-   gi|9910118    disintegrin and metalloproteinase domain-containing protein 1 precursor
RBR-   gi|999213     PEPT 2
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Predicted
Predicted
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Predicted
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Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
Predicted
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QM2-qcdsearch-74C25151AD4CE0FE-6D9B50D950C9C5AA

Query    gi accession no.
Q#1      gi|1065361
Q#3      gi|109016328
Q#3      gi|109016328
Q#4      gi|109086164
Q#5      gi|109086730
Q#7      gi|109110028
Q#10     gi|109122103
Q#15     gi|114621345
Q#15     gi|114621345
Q#16     gi|114621345
Q#17     gi|114621345
Q#20     gi|114621345
Q#20     gi|114621345
Q#21     gi|114621345
Q#24     gi|114621345
Q#28     gi|114621345
Q#31     gi|114666215
Q#31     gi|119612312
Q#31     gi|119619151
Q#32     gi|119900578
Q#35     gi|119910211
Q#41     gi|126294328
Q#42     gi|126303648
Q#44     gi|126304349
Q#45     gi|126304349
Q#45     gi|126304349
Q#53     gi|126309748
Q#55     gi|126310162
Q#55     gi|126310162
Q#55     gi|126311138
Q#55     gi|126311376
Q#57     gi|126324467
Q#58     gi|126324467
Q#58     gi|126324467
Q#58     gi|126324467
Q#58     gi|126324467
Q#58     gi|126324467
Q#58     gi|126331695
Q#58     gi|126334034
Q#58     gi|12751452
Q#58     gi|12751452
Q#59     gi|12751452
Q#59     gi|12845693
Q#60     gi|12846064
Q#60     gi|12846064
Q#61     gi|12851862
Q#63     gi|12853685
Q#64     gi|12853685
Q#69    gi|13562118
Q#69    gi|13562118
Q#71    gi|13562118
Q#72    gi|13562118
Q#74    gi|13562118
Q#74    gi|13562118
Q#74    gi|13562118
Q#74    gi|13562118
Q#75    gi|13562118
Q#75    gi|13562118
Q#76    gi|13562118
Q#76    gi|13562118
Q#76    gi|13562118
Q#76    gi|13562118
Q#88    gi|13562118
Q#91    gi|13562118
Q#94    gi|13562118
Q#97    gi|1374879
Q#98    gi|148664711
Q#100   gi|148684097
Q#101   gi|148698174
Q#104   gi|149042882
Q#104   gi|149049092
Q#104   gi|149049092
Q#109   gi|149409778
Q#111   gi|149412795
Q#112   gi|149412795
Q#114   gi|149412803
Q#117   gi|149485854
Q#118   gi|149485854
Q#119   gi|149485854
Q#122   gi|149592775
Q#122   gi|149592775
Q#134   gi|149638178
Q#135   gi|149720134
Q#135   gi|149720134
Q#137   gi|149722228
Q#143   gi|149731066
Q#145   gi|149757935
Q#145   gi|157504286
Q#145   gi|157818737
Q#145   gi|157818737
Q#151   gi|157821507
Q#154   gi|159162145
Q#155   gi|170649651
Q#156   gi|170649651
Q#156   gi|180946
Q#156   gi|1865644
Q#158   gi|187960160
Q#159   gi|190360663
Q#164   gi|1932712
Q#165   gi|1932712
Q#165   gi|193808
Q#166   gi|193808
Q#167   gi|193808
Q#169   gi|194217363
Q#173   gi|194226455
Q#173   gi|194226455
Q#175   gi|194226455
Q#175   gi|194227434
Q#176   gi|194373989
Q#176   gi|194373989
Q#176   gi|20071759
Q#176   gi|20071759
Q#176   gi|2119626
Q#176   gi|2119626
Q#176   gi|2119626
Q#176   gi|2119626
Q#176   gi|26333111
Q#176   gi|26336067
Q#176   gi|26336067
Q#176   gi|26336067
Q#176   gi|26348877
Q#176   gi|26348877
Q#176   gi|27806691
Q#176   gi|281306803
Q#176   gi|281306803
Q#176   gi|281306803
Q#176   gi|281306803
Q#176   gi|281306803
Q#176   gi|281306803
Q#180   gi|281306803
Q#181   gi|281337739
Q#181   gi|281337739
Q#182   gi|281337747
Q#182   gi|281337747
Q#183   gi|281337747
Q#184   gi|281353154
Q#184   gi|281353154
Q#186   gi|291387820
Q#187   gi|291390730
Q#188   gi|291390730
Q#189   gi|291392051
Q#191   gi|291399673
Q#192   gi|291403565
Q#193   gi|291403565
Q#197   gi|291409011
Q#201   gi|291410965
Q#202   gi|293346231
Q#203   gi|293346231
Q#203   gi|293346231
Q#203   gi|293346231
Q#203   gi|293346231
Q#205   gi|293346231
Q#206   gi|293346231
Q#207   gi|293346231
Q#207   gi|293346231
Q#208   gi|293346231
Q#208   gi|293346231
Q#209   gi|293346231
Q#211   gi|293346231
Q#212   gi|293346231
Q#212   gi|293346231
Q#213   gi|293346231
Q#215   gi|293347747
Q#218   gi|296190139
Q#221   gi|297291023
Q#222   gi|297291023
Q#224   gi|297291023
Q#227   gi|297291239
Q#230   gi|297295313
Q#230   gi|297295313
Q#231   gi|297295313
Q#231   gi|297295313
Q#233   gi|297295313
Q#233   gi|297303590
Q#234   gi|297661948
Q#234   gi|297661948
Q#234   gi|297661948
Q#234   gi|297671951
Q#234   gi|297671951
Q#234   gi|297671951
Q#234   gi|297671951
Q#234   gi|297682878
Q#238   gi|297682878
Q#240   gi|300300
Q#245   gi|301777842
Q#247   gi|307648425
Q#247   gi|307648431
Q#247   gi|309263499
Q#256   gi|311243931
Q#257   gi|311244608
Q#263   gi|311253094
Q#263   gi|311258229
Q#263   gi|311263940
Q#263   gi|311263940
Q#263   gi|311268641
Q#263   gi|32329380
Q#263   gi|34533800
Q#268   gi|3850728
Q#268   gi|400217
Q#270   gi|40786489
Q#271   gi|409226
Q#271   gi|409226
Q#271   gi|409226
Q#273   gi|409226
Q#275   gi|409226
Q#276   gi|409226
Q#276   gi|409226
Q#278   gi|409226
Q#280   gi|409226
Q#280   gi|409226
Q#280   gi|409226
Q#280   gi|437805
Q#280   gi|437805
Q#282   gi|4505753
Q#282   gi|4505753
Q#282   gi|4559318
Q#282   gi|466391
Q#285   gi|47523318
Q#285   gi|48425521
Q#288   gi|4885637
Q#289   gi|49258190
Q#290   gi|50927341
Q#290   gi|551597
Q#290   gi|551597
Q#290   gi|551597
Q#290   gi|551597
Q#294   gi|551597
Q#295   gi|551597
Q#297   gi|551597
Q#298   gi|5916179
Q#298   gi|5916179
Q#300   gi|62871256
Q#302   gi|73951182
Q#303   gi|73951182
Q#303   gi|73951182
Q#305   gi|73951182
Q#313   gi|73957808
Q#314   gi|73958855
Q#316   gi|73964993
Q#316   gi|73979856
Q#319   gi|73983780
Q#319   gi|74000055
Q#320   gi|74000055
Q#320   gi|74000055
Q#334   gi|9910118
D4CE0FE-6D9B50D950C9C5AA

        Protein short name
         Chain A, Human Adp-Ribosylation Factor 1 Complexed With Gdp, Full Length Non-Myristoylated
         peptidoglycan recognition protein 3-like isoform 1
         peptidoglycan recognition protein 3-like isoform 1
         steroidogenic acute regulatory protein, mitochondrial isoform 3
         hypothetical protein LOC697620
         ubiquitin carboxyl-terminal hydrolase 20-like
         RNA polymerase II transcription factor SIII subunit A2
         fibrocystin L
         fibrocystin L
         fibrocystin L
         fibrocystin L
         fibrocystin L
         fibrocystin L
         fibrocystin L
         fibrocystin L
         fibrocystin L
         sex hormone-binding globulin isoform 6
         hCG2008737
         hCG1790520
         piwi like homolog 2-like, partial
         dipeptidase 2
         hypothetical protein
         similar to HSRG1849
         similar to phospholipase C, beta 4
         similar to phospholipase C, beta 4
         similar to phospholipase C, beta 4
         similar to butyrophilin-like 8
         similar to LOC560387 protein
         similar to LOC560387 protein
         similar to phosphoglycerate kinase
         similar to acidic calponin
         similar to RBM19 protein
         similar to RBM19 protein
         similar to RBM19 protein
         similar to RBM19 protein
         similar to RBM19 protein
         similar to RBM19 protein
         similar to ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase), isoform 1
         hypothetical protein
         PDZ domain-containing protein AIPC
         PDZ domain-containing protein AIPC
         PDZ domain-containing protein AIPC
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
low-density lipoprotein receptor-related protein 2 precursor
nuclear hormone receptor
mCG1031578
mCG13235
mCG16273
rCG32230
solute carrier organic anion transporter family, member 1b2, isoform CRA_b
solute carrier organic anion transporter family, member 1b2, isoform CRA_b
similar to DNA polymerase iota
similar to Cadherin 9, type 2 (T1-cadherin)
similar to Cadherin 9, type 2 (T1-cadherin)
similar to transcription factor forkhead-like 7
similar to Phospholipase C, delta 1, partial
similar to Phospholipase C, delta 1, partial
similar to Phospholipase C, delta 1, partial
similar to ankyrin-repeat and fibronectin type III domain containing 1
similar to ankyrin-repeat and fibronectin type III domain containing 1
similar to Rad50
similar to glutathione S-transferase, theta 4
similar to glutathione S-transferase, theta 4
DEAH (Asp-Glu-Ala-His) box polypeptide 34
similar to Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted)
similar to pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
MHC class I antigen
probable histone-lysine N-methyltransferase ASH1L
probable histone-lysine N-methyltransferase ASH1L
PHD finger protein 20
Chain A, Rotamer Strain As A Determinant Of Protein Structural Specificity
coagulation factor VIII precursor (predicted)
coagulation factor VIII precursor (predicted)
cytochrome c oxidase subunit VIa
pancreatic lipase
BR serine/threonine-protein kinase 1
FYVE and coiled-coil domain-containing protein 1
prostate carcinoma tumor antigen
prostate carcinoma tumor antigen
tyrosine phosphatase
tyrosine phosphatase
tyrosine phosphatase
flotillin 2
similar to Werner syndrome ATP-dependent helicase
similar to Werner syndrome ATP-dependent helicase
similar to Werner syndrome ATP-dependent helicase
similar to Synaptotagmin-2 (Synaptotagmin II) (SytII)
unnamed protein product
unnamed protein product
Unknown (protein for MGC:36892)
Unknown (protein for MGC:36892)
cadherin 8 - human
cadherin 8 - human
cadherin 8 - human
cadherin 8 - human
unnamed protein product
unnamed protein product
unnamed protein product
unnamed protein product
unnamed protein product
unnamed protein product
lysosomal-trafficking regulator
myomesin 2
myomesin 2
myomesin 2
myomesin 2
myomesin 2
myomesin 2
myomesin 2
hypothetical protein PANDA_003017
hypothetical protein PANDA_003017
hypothetical protein PANDA_007621
hypothetical protein PANDA_007621
hypothetical protein PANDA_007621
hypothetical protein PANDA_003347
hypothetical protein PANDA_003347
EF-hand calcium binding domain 9-like
ATP-binding cassette transporter sub-family A member 15-like
ATP-binding cassette transporter sub-family A member 15-like
WD repeat domain 12 protein
oxidoreductase NAD-binding domain containing 1
homeodomain leucine zipper protein
homeodomain leucine zipper protein
zinc finger protein 84-like
serine/threonine kinase 30-like
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
spectrin, beta, non-erythrocytic 5
rCG63019-like
ubiquitin-associated protein 2
LOW QUALITY PROTEIN: fibrocystin-like
LOW QUALITY PROTEIN: fibrocystin-like
LOW QUALITY PROTEIN: fibrocystin-like
phosphoacetylglucosamine mutase
protocadherin gamma-B2-like
protocadherin gamma-B2-like
protocadherin gamma-B2-like
protocadherin gamma-B2-like
protocadherin gamma-B2-like
ferritin heavy chain-like
isoleucyl-tRNA synthetase, mitochondrial-like
isoleucyl-tRNA synthetase, mitochondrial-like
isoleucyl-tRNA synthetase, mitochondrial-like
LOW QUALITY PROTEIN: calpain-7-like
LOW QUALITY PROTEIN: calpain-7-like
LOW QUALITY PROTEIN: calpain-7-like
LOW QUALITY PROTEIN: calpain-7-like
oxygen-regulated protein 1-like
oxygen-regulated protein 1-like
CCAAT displacement protein, CDP
nephronectin-like
microcephalin
microcephalin
hypothetical protein LOC216818
ectonucleotide pyrophosphatase/phosphodiesterase family member 1, partial
probable E3 ubiquitin-protein ligase HERC1
structural maintenance of chromosomes protein 6-like
cytochrome c oxidase subunit 6B2-like
ubiquitin carboxyl-terminal hydrolase 28-like
ubiquitin carboxyl-terminal hydrolase 28-like
programmed cell death 6-interacting protein-like
T-cell receptor beta chain
unnamed protein product
MICA
RecName: Full=Interferon-induced guanylate-binding protein 1; AltName: Full=GTP-binding protein 1; Short=
rho guanine nucleotide exchange factor 25
brain beta spectrin
brain beta spectrin
brain beta spectrin
brain beta spectrin
brain beta spectrin
brain beta spectrin
brain beta spectrin
brain beta spectrin
brain beta spectrin
brain beta spectrin
brain beta spectrin
Laminin Ah
Laminin Ah
phosphoglycerate mutase 1
phosphoglycerate mutase 1
BC273239_1
zinc finger protein
ubiquitin carboxyl-terminal hydrolase isozyme L1
Chain B, Tsg101(Uev) Domain In Complex With Ubiquitin
target of Myb protein 1 isoform 1
NCK-interacting protein with SH3 domain
Zinc finger protein 61
epiligrin alpha 3 subunit
epiligrin alpha 3 subunit
epiligrin alpha 3 subunit
epiligrin alpha 3 subunit
epiligrin alpha 3 subunit
epiligrin alpha 3 subunit
epiligrin alpha 3 subunit
Msx2 interacting nuclear target protein
Msx2 interacting nuclear target protein
immunoglobulin alpha heavy chain variable region
similar to Proprotein convertase subtilisin/kexin type 6 precursor (Paired basic amino acid cleaving enzyme 4)
similar to Proprotein convertase subtilisin/kexin type 6 precursor (Paired basic amino acid cleaving enzyme 4)
similar to Proprotein convertase subtilisin/kexin type 6 precursor (Paired basic amino acid cleaving enzyme 4)
similar to Proprotein convertase subtilisin/kexin type 6 precursor (Paired basic amino acid cleaving enzyme 4)
similar to RAB, member of RAS oncogene family-like 5 (predicted)
similar to limkain b1 isoform 1 isoform 1
similar to likely ortholog of mouse ubiquitin-conjugating enzyme E2-230K
similar to Kinesin-like protein KIF3C isoform 7
similar to lectin, galactoside-binding, soluble, 12 (galectin 12)
similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (Phosphoinositide phospholipase
similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (Phosphoinositide phospholipase
similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (Phosphoinositide phospholipase
disintegrin and metalloproteinase domain-containing protein 1 precursor
Hit type   Domain short name
specific   Arf1_5_like
specific   PGRP
specific   PGRP
specific   START_STARD1-like
specific   Ubiquitin
specific   Peptidase_C19R
specific   TFIIS_I
specific   IPT_PCSR
specific   IPT_PCSR
specific   IPT_PCSR
specific   IPT_PCSR
specific   IPT_PCSR
specific   IPT_PCSR
specific   IPT_PCSR
specific   IPT_PCSR
specific   IPT_PCSR
specific   LamG
specific   CH
specific   Ubiquitin
specific   PAZ_piwi_like
specific   rDP_like
specific   KRAB_A-box
specific   LPLAT_LCLAT1-like
specific   PI-PLCc_beta
specific   C2_PLC_like
specific   PH_PLC
specific   Ig_MOG_like
specific   MAM
specific   EGF_CA
specific   Phosphoglycerate_kinase
specific   CH
specific   RRM
specific   RRM
specific   RRM
specific   RRM
specific   RRM
specific   RRM
specific   Peptidase_C12_UCH_L1_L3
specific   vWA_integrins_alpha_subunit
specific   PDZ_signaling
specific   PDZ_signaling
specific   PDZ_signaling
specific   Ribosomal_S15p_S13e
specific   EFh
specific   EFh
specific   SEC14
specific   EFh
specific   EFh
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   LDLa
specific   NR_LBD_SHP
specific   Ubiquitin
specific   Ubiquitin
specific   Ubiquitin
specific   KRAB_A-box
specific   KAZAL_SLC21
specific   MFS
specific   PolY_Pol_iota
specific   CA
specific   CA
specific   FH
specific   PI-PLCc_delta
specific   C2_PLC_like
specific   EFh
specific   FN3
specific   ANK
specific   ABC_Rad50
specific   GST_C_Theta
specific   GST_N_Theta
specific   DEXDc
specific   PH_melted
specific   PH
specific   IgC_MHC_I_alpha3
specific   BAH_polybromo
specific   Bromo_ASH1
specific   TUDOR
specific   Ubiquitin
specific   FA58C
specific   FA58C
specific   Cyt_c_Oxidase_VIa
specific   Pancreat_lipase_like
specific   PKc
specific   FYVE
specific   GLECT
specific   GLECT
specific   PTPc
specific   SH2
specific   SH2
specific   Band_7_flotillin
specific   RNaseD_like
specific   HELICc
specific   DEXDc
specific   C2A_Synaptotagmin-1-5-6-9-10
specific   PTPc
specific   PTPc
specific   EFh
specific   C2
specific   CA
specific   CA
specific   CA
specific   CA
specific   Ig
specific   CCP
specific   CCP
specific   CCP
specific   ZnMc_BMP1_TLD
specific   CUB
specific   Beach
specific   Ig_M-protein_C
specific   FN3
specific   FN3
specific   FN3
specific   FN3
specific   FN3
specific   Ig
specific   NT_PAP_TUTase
specific   NT_PAP_TUTase
specific   SH3
specific   SH3
specific   SH3
specific   C2_C2cd3
specific   C2
specific   EFh
specific   ABC_subfamily_A
specific   ABC_subfamily_A
specific   WD40
specific   FNR_like
specific   homeodomain
specific   homeodomain
specific   KRAB_A-box
specific   STKc_MOK
specific   SPEC
specific   CH
specific   SPEC
specific   SPEC
specific   SPEC
specific   SPEC
specific   SPEC
specific   CH
specific   SPEC
specific   SPEC
specific   SPEC
specific   SPEC
specific   SPEC
specific   SPEC
specific   SPEC
specific   SPEC
specific   Ubiquitin
specific   UBA
specific   IPT_PCSR
specific   IPT_PCSR
specific   IPT_PCSR
specific   PGM3
specific   CA
specific   CA
specific   CA
specific   CA
specific   CA
specific   Euk_Ferritin
specific   IleRS_core
specific   Anticodon_Ia_Ile_BEm
specific   IleRS_core
specific   CysPc
specific   MIT_calpain7_2
specific   MIT_calpain7_1
specific   Calpain_III
specific   DCX
specific   DCX
specific   homeodomain
specific   MAM
specific   BRCT
specific   BRCT
specific   Ubiquitin
specific   NUC
specific   HECTc
specific   ABC_SMC6_euk
specific   Cyt_c_Oxidase_VIb
specific   Peptidase_C19I
specific   Peptidase_C19I
specific   V_Alix
specific   IgV_TCR_beta
specific   C2_Kibra
specific   IgC_MHC_I_alpha3
specific   GBP
specific   RhoGEF
specific   PH_beta_spectrin
specific   SPEC
specific   SPEC
specific   SPEC
specific   SPEC
specific   SPEC
specific   SPEC
specific   SPEC
specific   CH
specific   CH
specific   SPEC
specific   LamG
specific   LamG
specific   HP_PGM_like
specific   HP_PGM_like
specific   KRAB_A-box
specific   KRAB_A-box
specific   Peptidase_C12_UCH_L1_L3
specific   Ubiquitin
specific   VHS_Tom1
specific   SH3
specific   KRAB_A-box
specific   LamG
specific   LamG
specific   LamG
specific   LamG
specific   EGF_Lam
specific   EGF_Lam
specific   LamG
specific   RRM
specific   RRM
specific   IgV_H
specific   Peptidases_S8_Protein_convertases_Kexins_Furin-lik
specific   FU
specific   FU
specific   FU
specific   Ras_like_GTPase
specific   RRM
specific   UBCc
specific   KISc_KIF3
specific   GLECT
specific   PI-PLCc_beta
specific   C2_PLC_like
specific   PH_PLC
specific   ZnMc_adamalysin_II_like
Definition
Arf1-Arf5-like subfamily. This subfamily contains Arf1, Arf2, Arf3, Arf4, Arf5, and related proteins. Arfs1-5 are
Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hy
Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hy
Cholesterol-binding START domain of mammalian STARD1 and related proteins; This subgroup includes the ste
Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin pr
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases t
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elong
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT dom
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT dom
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT dom
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT dom
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT dom
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT dom
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT dom
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT dom
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT dom
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites fo
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats
Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin pr
PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the m
renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a m
KRAB (Kruppel-associated box) domain -A box.; The KRAB domain is a transcription repression module, found
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta; This subfamily corresponds to th
C2 domain present in Phosphoinositide-specific phospholipases C (PLC); PLCs are involved in the hydrolysis of p
Phospholipase C (PLC) pleckstrin homology (PH) domain; Phospholipase C (PLC) pleckstrin homology (PH) dom
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); Ig_MOG_like: immunoglobuli
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly ani
Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosph
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is
Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3; This ubiquit
Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate w
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be resp
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be resp
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be resp
Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most
Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfe
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian
The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain; The ligand binding
Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin pr
Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin pr
Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin pr
KRAB (Kruppel-associated box) domain -A box.; The KRAB domain is a transcription repression module, found
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carr
The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes un
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion sy
Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these dom
Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these dom
Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcripti
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta; This subfamily corresponds to t
C2 domain present in Phosphoinositide-specific phospholipases C (PLC); PLCs are involved in the hydrolysis of p
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its te
ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The
The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associa
GST_C family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane
GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding
Melted pleckstrin homology (PH) domain; Melted pleckstrin homology (PH) domain. The melted protein has a C
Pleckstrin homology (PH) domain; Pleckstrin homology (PH) domain. PH domains are only found in eukaryotes.
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; IgC_MHC_I_alpha3; Imm
BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interaction
Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin pr
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domai
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domai
Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chain
Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- a
Catalytic domain of Protein Kinases; Protein Kinases (PKs), catalytic (c) domain. PKs catalyze the transfer of th
FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinosit
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does no
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does no
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate
Src homology 2 domains; Signal transduction, involved in recognition of phosphorylated tyrosine (pTyr). SH2 d
Src homology 2 domains; Signal transduction, involved in recognition of phosphorylated tyrosine (pTyr). SH2 d
Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains prot
DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins; The RNase D-like group is composed
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiati
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding
C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10; Synaptotagmin is a membrane-traffickin
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate
Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that c
Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these dom
Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these dom
Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these dom
Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these dom
Immunoglobulin domain; Ig: immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been id
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been id
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been id
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tol
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of pr
C-terminal immunoglobulin (Ig)-like domain of M-protein (also known as myomesin-2); Ig_M-protein_C: the C-
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its te
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its te
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its te
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its te
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its te
Immunoglobulin domain; Ig: immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases.; Poly(A) polyme
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases.; Poly(A) polyme
Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, prefe
Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, prefe
Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, prefe
C2 domain found in C2 calcium-dependent domain containing 3 (C2cd3) proteins; C2cd3 is a novel C2 domain-
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that c
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most
The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA su
The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA su
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adapto
Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reducta
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmenta
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmenta
KRAB (Kruppel-associated box) domain -A box.; The KRAB domain is a transcription repression module, found
Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; Serine/Threonine Kinase
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin pr
Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of th
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT dom
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT dom
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT dom
PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetyl
Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these dom
Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these dom
Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these dom
Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these dom
Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these dom
eukaryotic ferritins; Eukaryotic Ferritin (Euk_Ferritin) domain. Ferritins are the primary iron storage proteins of
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic c
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic c
Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytos
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domain
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domain
Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoske
Ubiquitin-like domain of DCX; DCX The ubiquitin-like DCX domain is present in tandem within the N-terminal
Ubiquitin-like domain of DCX; DCX The ubiquitin-like DCX domain is present in tandem within the N-terminal
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmenta
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many D
Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many D
Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin pr
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA end
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiqu
Eukaryotic SMC6 proteins; SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into f
Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases t
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases t
Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules; Thi
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) bet a chain; IgV_TCR_beta: immunoglobulin
C2 domain found in Human protein Kibra; Kibra is thought to be a regulator of the Salvador (Sav)/Warts (Wts)
Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain; IgC_MHC_I_alpha3; Imm
Guanylate-binding protein (GBP), N-terminal domain. Guanylate-binding proteins (GBPs) define a group of prot
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain
Beta-spectrin pleckstrin homology (PH) domain; Beta-spectrin pleckstrin homology (PH) domain. Beta spectrin
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin,
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites fo
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites fo
Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; c
Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; c
KRAB (Kruppel-associated box) domain -A box.; The KRAB domain is a transcription repression module, found
KRAB (Kruppel-associated box) domain -A box.; The KRAB domain is a transcription repression module, found
Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3; This ubiquit
Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin pr
VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral
Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, prefe
KRAB (Kruppel-associated box) domain -A box.; The KRAB domain is a transcription repression module, found
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites fo
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites fo
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites fo
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites fo
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of base
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of base
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites fo
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; IgV_H: Immunoglobulin (Ig) heavy chain (H), varia
Peptidase S8 family domain in Protein convertases; Protein convertases, whose members include furins and kex
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dep
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dep
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dep
Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an ext
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degra
Kinesin motor domain, kinesins II or KIF3_like proteins. Subgroup of kinesins, which form heterotrimers compo
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does no
Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta; This subfamily corresponds to th
C2 domain present in Phosphoinositide-specific phospholipases C (PLC); PLCs are involved in the hydrolysis of p
Phospholipase C (PLC) pleckstrin homology (PH) domain; Phospholipase C (PLC) pleckstrin homology (PH) dom
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopept
 d related proteins. Arfs1-5 are soluble proteins that are crucial for assembling coat proteins during vesicle formation. Eac
at bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three c
at bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three c
   This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD
homopolymeric multiubiquitin protein chains)
 ey are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide b
milar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with
This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepato
This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepato
This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepato
This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepato
This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepato
This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepato
This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepato
This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepato
This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepato
  s that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins
ngle copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transd
homopolymeric multiubiquitin protein chains)
 ppears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be
 microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolis
  tion repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs
 : LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling
This subfamily corresponds to the catalytic domain present in metazoan phosphoinositide-specific phospholipase C (PI-PLC
 e involved in the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PIP2) to d-myo-inositol-1,4,5-trisphosphate (1,4,5-
   pleckstrin homology (PH) domain. There are several isozymes of PLC (beta, gamma, delta, epsilon. zeta). While, PLC beta
 ; Ig_MOG_like: immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor componen
s an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of wh
nd and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calciu
nsfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This re
ngle copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transd
 (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional g
 (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional g
 (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional g
 (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional g
 (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional g
 (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional g
 families L1 and L3; This ubiquitin C-terminal hydrolase (UCH) family includes UCH-L1 and UCH-L3, the two members shar
he cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migrat
  em arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal poly
  em arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal poly
  em arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal poly
  of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representin
alcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces
alcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces
 siae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofib
alcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces
alcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
ays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by end
  ing domain; The ligand binding domain of the Small Heterodimer Partner (SHP): SHP is a member of the nuclear receptor
homopolymeric multiubiquitin protein chains)
homopolymeric multiubiquitin protein chains)
homopolymeric multiubiquitin protein chains)
  tion repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs
ellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the spec
ry transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasm
LS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases la
 d cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell con
 d cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell con
  fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of trans
 This subfamily corresponds to the catalytic domain present in metazoan phosphoinositide-specific phospholipase C (PI-PLC
 e involved in the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PIP2) to d-myo-inositol-1,4,5-trisphosphate (1,4,5-
alcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces
 lasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop
 verse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). A
ransporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad
  and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification
  and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification
 pendent RNA or DNA unwinding. This domain contains the ATP-binding region.
ain. The melted protein has a C-terminal PH domain. PH domains share little sequence conservation, but all have a commo
  s are only found in eukaryotes. They share little sequence conservation, but all have a common fold, which is electrostatic
main; IgC_MHC_I_alpha3; Immunoglobulin (Ig) domain of major histocompatibility complex (MHC) class I alpha chain. C
RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It
member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophi
ed in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor d
homopolymeric multiubiquitin protein chains)
 ed carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genom
 ed carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genom
oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the in
 hain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical featu
   PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein su
eraction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1;
 es, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeate
 es, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeate
 yrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft r
 orylated tyrosine (pTyr). SH2 domains typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydropho
 orylated tyrosine (pTyr). SH2 domains typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydropho
ns. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipi
Nase D-like group is composed of RNase D, WRN, and similar proteins. They contain a DEDDy-type, DnaQ-like, 3'-5' exonu
 EAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide var
 pendent RNA or DNA unwinding. This domain contains the ATP-binding region.
 agmin is a membrane-trafficking protein characterized by a N-terminal transmembrane region, a linker, and 2 C-terminal
 yrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft r
 yrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft r
alcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces
8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permut
 d cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell con
 d cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell con
 d cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell con
 d cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell con
family. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two be
or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-
or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-
or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-
ogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving pre
 ved in development; not found in prokaryotes, plants and yeast.
 g, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking
esin-2); Ig_M-protein_C: the C-terminal immunoglobulin (Ig)-like domain of M-protein (also known as myomesin-2). M-pr
lasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop
lasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop
lasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop
lasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop
lasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop
family. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two be
 l transferases.; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTa
 l transferases.; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTa
 te affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular int
 te affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular int
 te affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular int
 s; C2cd3 is a novel C2 domain-containing protein specific to vertebrates. C2cd3 functions in regulator of cilia formation, H
8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permut
alcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces
 tations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprot
 tations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprot
ty of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assem
entified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to N
 of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequen
 of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequen
 tion repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs
Kinase; Serine/Threonine Kinases (STKs), MAPK/MAK/MRK Overlapping Kinase (MOK) subfamily, catalytic (c) domain. STK
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
ngle copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transd
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
ngle copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transd
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
homopolymeric multiubiquitin protein chains)
 e motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although
This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepato
This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepato
This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepato
  e mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibl
 d cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell con
 d cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell con
 d cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell con
 d cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell con
 d cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell con
primary iron storage proteins of most living organisms and members of a broad superfamily of ferritin-like diiron-carboxyla
A synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucle
 NA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA s
A synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucle
 , papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
 . This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is
 . This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is
oteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic
   tandem within the N-terminal half of the doublecortin protein. Doublecortin is expressed in migrating neurons. Mutation
   tandem within the N-terminal half of the doublecortin protein. Doublecortin is expressed in migrating neurons. Mutation
 of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequen
s an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of wh
   domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain s
   domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain s
homopolymeric multiubiquitin protein chains)
ngle-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimer
ase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate ly
Da), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between specie
xidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inn
 ey are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide b
 ey are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide b
protein interaction modules; This family contains the middle V-shaped (V) domain of mammalian Alix (apoptosis-linked ge
gV_TCR_beta: immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs
 he Salvador (Sav)/Warts (Wts)/Hippo (Hpo) (SWH) signaling network, which limits tissue growth by inhibiting cell prolifer
main; IgC_MHC_I_alpha3; Immunoglobulin (Ig) domain of major histocompatibility complex (MHC) class I alpha chain. C
ns (GBPs) define a group of proteins that are synthesized after activation of the cell by interferons. The biochemical proper
d Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
ogy (PH) domain. Beta spectrin binds actin and functions as a major component of the cytoskeleton underlying cellular me
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
ngle copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transd
ngle copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transd
mily members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the secon
 s that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins
 s that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins
 roteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction.; Subgroup of the cataly
 roteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction.; Subgroup of the cataly
 tion repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs
 tion repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs
 families L1 and L3; This ubiquitin C-terminal hydrolase (UCH) family includes UCH-L1 and UCH-L3, the two members shar
homopolymeric multiubiquitin protein chains)
 m1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure o
 te affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular int
 tion repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs
 s that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins
 s that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins
 s that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins
 s that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins
 ollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the lam
 ollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the lam
 s that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins
 (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional g
 (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional g
bulin (Ig) heavy chain (H), variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and tw
 members include furins and kexins, are members of the peptidase S8 or Subtilase clan of proteases. They have an Asp/His
wn. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell
wn. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell
wn. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell
s of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided in
 (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional g
biquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the
which form heterotrimers composed of 2 kinesins and one non-motor accessory subunit. Kinesins II play important roles in
 es, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeate
This subfamily corresponds to the catalytic domain present in metazoan phosphoinositide-specific phospholipase C (PI-PLC
 e involved in the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PIP2) to d-myo-inositol-1,4,5-trisphosphate (1,4,5-
  pleckstrin homology (PH) domain. There are several isozymes of PLC (beta, gamma, delta, epsilon. zeta). While, PLC beta
s a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane
ns during vesicle formation. Each contains an N-terminal myristoylated amphipathic helix that is folded into the protein in
  have been divided into three classes: short PGRPs (PGRP-S), that are small (20 kDa) extracellular proteins; intermediate
  have been divided into three classes: short PGRPs (PGRP-S), that are small (20 kDa) extracellular proteins; intermediate
 sfer (START) domains of STARD1 (also known as StAR) and related proteins. It belongs to the START domain family, and

des by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of u
main I from TFIIS interacts with RNA polymerase II holoenzyme
wth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibroc
wth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibroc
wth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibroc
wth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibroc
wth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibroc
wth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibroc
wth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibroc
wth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibroc
wth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibroc
d alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via c
 n cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, ut

germline, Piwi was shown to be involved in the silencing of retrotransposons in the male gametes. The Piwi proteins share
 nvolved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. Although the biological function of th
  family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found i
 ases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl
pecific phospholipase C (PI-PLC, EC 3.1.4.11)-beta isozymes. PI-PLC is a signaling enzyme that hydrolyzes the membrane
 tol-1,4,5-trisphosphate (1,4,5-IP3) and sn-1,2-diacylglycerol (DAG). 1,4,5-IP3 and DAG are second messengers in eukar
 , epsilon. zeta). While, PLC beta, gamma and delta all have N-terminal PH domains, lipid binding specificity is not conserv
MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenes
 rse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyro
eir biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like dom
and 3-phosphoglycerate. This reaction represents the first of the two substrate-level phosphorylation events in the glycolyt
 n cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, ut
nvolved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stab
nvolved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stab
nvolved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stab
nvolved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stab
nvolved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stab
nvolved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stab
UCH-L3, the two members sharing around 53% sequence identity as well as conserved catalytic residues. Both enzymes h
ycle progression and cell migration. Integrins consist of an alpha and a beta sub-unit. Each sub-unit has a large extracellul
Z domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to lipids has been
Z domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to lipids has been
Z domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to lipids has been
nit association, thus representing a key element in the assembly of the whole ribosome. S15 also plays an important autor
EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of t
EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of t
RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subu
EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of t
EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of t
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
d transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-te
member of the nuclear receptor superfamily. SHP has a ligand binding domain, but lacks the DNA binding domain, typical




  family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found i
) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-
e the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drug
NA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA
thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate, signalling, proliferation, differentiation
thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate, signalling, proliferation, differentiation
evelopment. This family of transcription factor domains, which bind to B-DNA as monomers, are also found in the Hepatocy
 pecific phospholipase C (PI-PLC, EC 3.1.4.11)-delta isozymes. PI-PLC is a signaling enzyme that hydrolyzes the membrane
 tol-1,4,5-trisphosphate (1,4,5-IP3) and sn-1,2-diacylglycerol (DAG). 1,4,5-IP3 and DAG are second messengers in eukar
EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of t
tion sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; includ
 r 20 (ankyrins, for example). ANK repeats may occur in combinations with other types of domains. The structural repeat u
 -binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a
 volved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and x
 volved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and x

 servation, but all have a common fold, which is electrostatically polarized. PH domains also have diverse functions. They a
mmon fold, which is electrostatically polarized. PH domains also have diverse functions. They are often involved in targeting
 ex (MHC) class I alpha chain. Class I MHC proteins bind antigenic peptide fragments and present them to CD8+ T lymphoc
 n-remodeling complex PBAF. It is thought that polybromo participates in transcriptional regulation. Saccharomyces cerevis
 gulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian A
  ains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to symmetrically dimethylated arginines of

 transferred to eubacterial genomes.
 transferred to eubacterial genomes.
 mbrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the red
 /lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water int
  tyrosine residues on protein substrates. The PK family is part of a larger superfamily that includes the catalytic domains o

 omodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, ce
 omodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, ce
 e depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (pTyr) residues, instead of pSer or pThr
 e pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphoryla
 e pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphoryla
 cin. These two proteins are lipid raft-associated. Individual proteins of this band 7 domain family may cluster to form me
 Dy-type, DnaQ-like, 3'-5' exonuclease domain that contains three conserved sequence motifs termed ExoI, ExoII and ExoI
 s domain is found in a wide variety of helicases and helicase related proteins; may not be an autonomously folding unit, b

gion, a linker, and 2 C-terminal C2 domains. Synaptotagmin 1, a member of class 1 synaptotagmins, is located in the brain
  e depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (pTyr) residues, instead of pSer or pThr
  e depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (pTyr) residues, instead of pSer or pThr
EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of t
 tinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependen
 thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate, signalling, proliferation, differentiation
 thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate, signalling, proliferation, differentiation
 thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate, signalling, proliferation, differentiation
 thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate, signalling, proliferation, differentiation
mprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surfac
  HI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control pr
  HI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control pr
  HI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control pr
matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, and proteins involved in the mineral

ns human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disrupti
  o known as myomesin-2). M-protein is a structural protein localized to the M-band, a transverse structure in the center of
tion sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; includ
tion sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; includ
tion sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; includ
tion sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; includ
tion sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; includ
mprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surfac
minal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific
minal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific
 f enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate
 f enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate
 f enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate
 in regulator of cilia formation, Hedgehog signaling, and mouse embryonic development. Mutations in C2cd3 mice resulted
 tinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependen
EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of t
 s, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency, degenerative retinopathies, and conge
 s, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency, degenerative retinopathies, and conge
  essing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipep
  n-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfer
nd/or heterodimers, in a sequence-specific manner.
nd/or heterodimers, in a sequence-specific manner.
  family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found i
amily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residu
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
  n cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, ut
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
 n cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, ut
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit

ertain protein kinases. Although its specific role is so far unknown, it has been suggested that UBA domains are involved in
wth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibroc
wth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibroc
wth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibroc
und in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into GlcNAc-1-phosphate as part of the U
thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate, signalling, proliferation, differentiation
thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate, signalling, proliferation, differentiation
thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate, signalling, proliferation, differentiation
thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate, signalling, proliferation, differentiation
thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate, signalling, proliferation, differentiation
y of ferritin-like diiron-carboxylate proteins. The iron-free (apoferritin) ferritin molecule is a protein shell composed of 24 p
 oacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and
to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically
 oacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and
  and signal transduction.
 r function of the MIT domain is unclear.
 r function of the MIT domain is unclear.
nd signal transduction. Catalytic domain and the two calmodulin-like domains are separated by C2-like domain III. Domain
 n migrating neurons. Mutations in the gene encoding doublecortin cause lissencephaly in males and 'double-cortex syndr
 n migrating neurons. Mutations in the gene encoding doublecortin cause lissencephaly in males and 'double-cortex syndr
nd/or heterodimers, in a sequence-specific manner.
 rse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyro
unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-n
unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-n

 s as monomers and homodimers.
 ansfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquit
of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-term
 brane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the redu
des by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of u
des by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of u
malian Alix (apoptosis-linked gene-2 interacting protein X) and related domains. It belongs to the V_Alix_like superfamily w
antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or ga
growth by inhibiting cell proliferation and promoting apoptosis. The core of the pathway consists of a MST and LATS family
ex (MHC) class I alpha chain. Class I MHC proteins bind antigenic peptide fragments and present them to CD8+ T lymphoc
 ferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding pro
 RhoGEF/DH domains.
 skeleton underlying cellular membranes. Beta spectrin consists of multiple spectrin repeats followed by a PH domain, whic
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
 n cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, ut
 n cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, ut
hree helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding unit
d alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via c
d alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via c
 action.; Subgroup of the catalytic domain of a functionally diverse set of proteins, most of which are phosphatases. The co
 action.; Subgroup of the catalytic domain of a functionally diverse set of proteins, most of which are phosphatases. The co
 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found i
 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found i
UCH-L3, the two members sharing around 53% sequence identity as well as conserved catalytic residues. Both enzymes h

ucture similar to the structure of the ARM repeats and is present at the very N-termini of proteins. It is a right-handed supe
f enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate
  family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found i
 d alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via c
 d alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via c
 d alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via c
 d alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via c
tion, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain conta
tion, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain conta
 d alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via c
nvolved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stab
nvolved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stab
ramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable do
 roteases. They have an Asp/His/Ser catalytic triad that is not homologous to trypsin. Kexins are involved in the activation
 nclude endoproteases and cell surface receptors.
 nclude endoproteases and cell surface receptors.
 nclude endoproteases and cell surface receptors.
he Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This supe
nvolved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stab
n a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin protein ligase enzymes, E3. This pat
 esins II play important roles in ciliary transport, and have been implicated in neuronal transport, melanosome transport, t
 omodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, ce
pecific phospholipase C (PI-PLC, EC 3.1.4.11)-beta isozymes. PI-PLC is a signaling enzyme that hydrolyzes the membrane
 tol-1,4,5-trisphosphate (1,4,5-IP3) and sn-1,2-diacylglycerol (DAG). 1,4,5-IP3 and DAG are second messengers in eukar
 , epsilon. zeta). While, PLC beta, gamma and delta all have N-terminal PH domains, lipid binding specificity is not conserv
 oteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Met
hat is folded into the protein in the GDP-bound state. GDP/GTP exchange exposes the helix, which anchors to the membra
acellular proteins; intermediate PGRPs (PGRP-I) that are 40-45 kDa and are predicted to be transmembrane proteins; and
acellular proteins; intermediate PGRPs (PGRP-I) that are 40-45 kDa and are predicted to be transmembrane proteins; and
the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily

 the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conju

mulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and
mulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and
mulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and
mulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and
mulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and
mulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and
mulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and
mulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and
mulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and
luding signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of c
 n, alpha-actinin, dystrophin, utrophin, and fimbrin, proteins essential for regulation of cell shape (cortexillins), and signal

 metes. The Piwi proteins share their domain architecture with other members of the argonaute family. The PAZ domain ha
ugh the biological function of the enzyme is still unknown, it has been suggested to play a role in the renal glutathione me
mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation a
 ze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as g
 that hydrolyzes the membrane phospholipids phosphatidylinositol-4,5-bisphosphate (PIP2) to generate two important sec
are second messengers in eukaryotic signal transduction cascades. PLC is composed of a N-terminal PH domain followed by
inding specificity is not conserved between them. PH domains share little sequence conservation, but all have a common
tigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a
 : type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neur
minus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conse
horylation events in the glycolytic pathway. Substrate-level phosphorylation is defined as production of ATP by a process,
 n, alpha-actinin, dystrophin, utrophin, and fimbrin, proteins essential for regulation of cell shape (cortexillins), and signal
sing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet pa
sing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet pa
sing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet pa
sing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet pa
sing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet pa
sing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet pa
alytic residues. Both enzymes hydrolyze carboxyl terminal esters and amides of ubiquitin (Ub). UCH-L1, in dimeric form, h
sub-unit has a large extracellular portion, a single transmembrane segment and a short cytoplasmic domain. The N-termin
ides and even to lipids has been demonstrated. In this subfamily of PDZ domains an N-terminal beta-strand forms the pep
ides and even to lipids has been demonstrated. In this subfamily of PDZ domains an N-terminal beta-strand forms the pep
ides and even to lipids has been demonstrated. In this subfamily of PDZ domains an N-terminal beta-strand forms the pep
 5 also plays an important autoregulatory role by binding and preventing its own mRNA from being translated. S15 has a p
he activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.
he activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.
 ith G protein beta/gamma subunits.
he activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.
he activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
no acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related
e DNA binding domain, typical to almost all of the nuclear receptors. It functions as a transcriptional coregulator by directl




mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation a
ber of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.
ng ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electro
ssivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of
 ing, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-,CNR-,proto-,and FAT-family cadherin
 ing, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-,CNR-,proto-,and FAT-family cadherin
 , are also found in the Hepatocyte nuclear factor (HNF) proteins, which provide tissue-specific gene regulation. The structu
e that hydrolyzes the membrane phospholipids phosphatidylinositol-4,5-bisphosphate (PIP2) to generate two important se
are second messengers in eukaryotic signal transduction cascades. PLC is composed of a N-terminal PH domain followed by
he activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.
s contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth
 omains. The structural repeat unit contains two antiparallel helices and a beta-hairpin, repeats are stacked in a superhelic
d Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This con
wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins
wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins

 have diverse functions. They are often involved in targeting proteins to the plasma membrane, but few display strong spe
y are often involved in targeting proteins to the plasma membrane, but few display strong specificity in lipid binding. Any
esent them to CD8+ T lymphocytes. Class I molecules consist of a transmembrane alpha chain and a small chain called t
ulation. Saccharomyces cerevisiae RSC1 and RSC2 are part of the 15-subunit nucleosome remodeling RSC complex. BAH d
tones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long dom
cally dimethylated arginines of arginine-glycine (RG) rich sequences found in the C-terminal tails of Sm proteins. The SMN




rokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of su
ing active at the lipid/water interface, although several examples of lipases have been identified that do not undergo inter
ncludes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kina

e involved in differentiation, cell-cell interaction and cellular regulation.
e involved in differentiation, cell-cell interaction and cellular regulation.
esidues, instead of pSer or pThr. This family has a distinctive active site signature motif, HCSAGxGRxG. Characterized as e
 ocalize to tyrosine phosphorylated sites.
 ocalize to tyrosine phosphorylated sites.
n family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains for
ifs termed ExoI, ExoII and ExoIII, with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active sit
an autonomously folding unit, but an integral part of the helicase; 4 helicase superfamilies at present according to the orga

otagmins, is located in the brain and endocranium and localized to the synaptic vesicles and secretory granules. It functio
esidues, instead of pSer or pThr. This family has a distinctive active site signature motif, HCSAGxGRxG. Characterized as e
esidues, instead of pSer or pThr. This family has a distinctive active site signature motif, HCSAGxGRxG. Characterized as e
he activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.
C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phos
 ing, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-,CNR-,proto-,and FAT-family cadherin
 ing, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-,CNR-,proto-,and FAT-family cadherin
 ing, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-,CNR-,proto-,and FAT-family cadherin
 ing, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-,CNR-,proto-,and FAT-family cadherin
 oglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, su
 ins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) conta
 ins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) conta
 ins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) conta
proteins involved in the mineralization of the extracellular matrix. The drosophila protein tolloid and its Xenopus homologu

BA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency,
 verse structure in the center of the sarcomere, and is a candidate for M-band bridges. M-protein is modular consisting ma
s contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth
s contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth
s contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth
s contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth
s contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth
 oglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, su
AP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 a
AP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 a
 hway components and mediate multiprotein complex assemblies.
 hway components and mediate multiprotein complex assemblies.
 hway components and mediate multiprotein complex assemblies.
utations in C2cd3 mice resulted in lethality in some cases and exencephaly, a twisted body axis, and pericardial edema in o
C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phos
he activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.
 rative retinopathies, and congenital keratinization disorders. The ABCA1 protein is involved in disorders of cholesterol tra
 rative retinopathies, and congenital keratinization disorders. The ABCA1 protein is involved in disorders of cholesterol tra
ts N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and W
  of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediat


mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation a
m ATP to serine/threonine residues on protein substrates. The MOK subfamily is part of a larger superfamily that includes t
ats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to
 n, alpha-actinin, dystrophin, utrophin, and fimbrin, proteins essential for regulation of cell shape (cortexillins), and signal
ats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to
ats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to
ats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to
ats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to
 ats are independent folding units; tandem repeats are found      in differing numbers and arrange in an antiparallel manner to
  n, alpha-actinin, dystrophin, utrophin, and fimbrin, proteins   essential for regulation of cell shape (cortexillins), and signal
 ats are independent folding units; tandem repeats are found      in differing numbers and arrange in an antiparallel manner to
 ats are independent folding units; tandem repeats are found      in differing numbers and arrange in an antiparallel manner to
 ats are independent folding units; tandem repeats are found      in differing numbers and arrange in an antiparallel manner to
 ats are independent folding units; tandem repeats are found      in differing numbers and arrange in an antiparallel manner to
 ats are independent folding units; tandem repeats are found      in differing numbers and arrange in an antiparallel manner to
 ats are independent folding units; tandem repeats are found      in differing numbers and arrange in an antiparallel manner to
 ats are independent folding units; tandem repeats are found      in differing numbers and arrange in an antiparallel manner to
 ats are independent folding units; tandem repeats are found      in differing numbers and arrange in an antiparallel manner to

hat UBA domains are involved in conferring protein target specificity. The domain, a compact three helix bundle, has a con
mulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and
mulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and
mulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and
 Ac-1-phosphate as part of the UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthetic pathway. UDP-GlcNAc is an essential
ing, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-,CNR-,proto-,and FAT-family cadherin
ing, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-,CNR-,proto-,and FAT-family cadherin
ing, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-,CNR-,proto-,and FAT-family cadherin
ing, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-,CNR-,proto-,and FAT-family cadherin
ing, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-,CNR-,proto-,and FAT-family cadherin
 protein shell composed of 24 protein chains arranged in 432 symmetry. Iron storage involves the uptake of iron (II) at the
 based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate
 and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial m
 based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate




d by C2-like domain III. Domain III plays an important role in calcium-induced activation of calpain involving electrostatic
males and 'double-cortex syndrome' in females.
males and 'double-cortex syndrome' in females.

 : type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neur
 hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.
 hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.


 es to the end of growing ubiquitin chains.
obular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-l
 okaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subun
  the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conju
  the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conju
 to the V_Alix_like superfamily which includes the V-domains of Bro1 and Rim20 (also known as PalA) from Saccharomyces
mposed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group i
  sists of a MST and LATS family kinase cascade that ultimately phosphorylates and inactivates the YAP/Yorkie (Yki) transcr
 esent them to CD8+ T lymphocytes. Class I molecules consist of a transmembrane alpha chain and a small chain called t
  heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in th

  followed by a PH domain, which binds to    Inositol-1,4,5-Trisphosphate.    PH domains share little sequence conservation, bu
 ats are independent folding units; tandem   repeats are found in differing   numbers and arrange in an antiparallel manner to
 ats are independent folding units; tandem   repeats are found in differing   numbers and arrange in an antiparallel manner to
 ats are independent folding units; tandem   repeats are found in differing   numbers and arrange in an antiparallel manner to
ats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to
ats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to
ats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to
ats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to
 n, alpha-actinin, dystrophin, utrophin, and fimbrin, proteins essential for regulation of cell shape (cortexillins), and signal
 n, alpha-actinin, dystrophin, utrophin, and fimbrin, proteins essential for regulation of cell shape (cortexillins), and signal
ats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to
luding signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of c
luding signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of c
which are phosphatases. The conserved catalytic core of this domain contains a His residue which is phosphorylated in the
which are phosphatases. The conserved catalytic core of this domain contains a His residue which is phosphorylated in the
mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation a
mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation a
alytic residues. Both enzymes hydrolyze carboxyl terminal esters and amides of ubiquitin (Ub). UCH-L1, in dimeric form, h

oteins. It is a right-handed superhelix of eight alpha helices. The VHS domain has been found in a number of proteins, som
hway components and mediate multiprotein complex assemblies.
mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation a
luding signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of c
luding signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of c
luding signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of c
luding signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of c
ndem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); th
ndem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); th
luding signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of c
sing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet pa
sing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet pa
 is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the
 s are involved in the activation of peptide hormones, growth factors, and viral proteins. Furin cleaves cell surface vasoact




 nd Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alph
sing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet pa
n ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form
 sport, melanosome transport, the secretory pathway, and mitosis. This catalytic (head) domain has ATPase activity and be
e involved in differentiation, cell-cell interaction and cellular regulation.
 that hydrolyzes the membrane phospholipids phosphatidylinositol-4,5-bisphosphate (PIP2) to generate two important sec
are second messengers in eukaryotic signal transduction cascades. PLC is composed of a N-terminal PH domain followed by
inding specificity is not conserved between them. PH domains share little sequence conservation, but all have a common
  ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell in
x, which anchors to the membrane. Following GTP hydrolysis, the helix dissociates from the membrane and folds back into
e transmembrane proteins; and long PGRPs (PGRP-L), up to 90 kDa, which may be either intracellular or transmembrane.
e transmembrane proteins; and long PGRPs (PGRP-L), up to 90 kDa, which may be either intracellular or transmembrane.
CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligan

be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. Th

ion and of cellular adhesion and repulsion receptors. In   general,   there   are   three   copies   of   the   IPT_PCSR   domain   present   pr
ion and of cellular adhesion and repulsion receptors. In   general,   there   are   three   copies   of   the   IPT_PCSR   domain   present   pr
ion and of cellular adhesion and repulsion receptors. In   general,   there   are   three   copies   of   the   IPT_PCSR   domain   present   pr
ion and of cellular adhesion and repulsion receptors. In   general,   there   are   three   copies   of   the   IPT_PCSR   domain   present   pr
ion and of cellular adhesion and repulsion receptors. In   general,   there   are   three   copies   of   the   IPT_PCSR   domain   present   pr
ion and of cellular adhesion and repulsion receptors. In   general,   there   are   three   copies   of   the   IPT_PCSR   domain   present   pr
ion and of cellular adhesion and repulsion receptors. In   general,   there   are   three   copies   of   the   IPT_PCSR   domain   present   pr
ion and of cellular adhesion and repulsion receptors. In   general,   there   are   three   copies   of   the   IPT_PCSR   domain   present   pr
ion and of cellular adhesion and repulsion receptors. In   general,   there   are   three   copies   of   the   IPT_PCSR   domain   present   pr
entiation through mediation of cell adhesion molecules.
 shape (cortexillins), and signaling proteins (Vav).

aute family. The PAZ domain has been named after the proteins Piwi, Argonaut, and Zwille. PAZ is found in two families of
role in the renal glutathione metabolism.
 ant roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domai
ylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in th
  to generate two important second messengers in eukaryotic signal transduction cascades, Inositol 1,4,5-trisphosphate (
 terminal PH domain followed by a series of EF hands, a catalytic TIM barrel and a C-terminal C2 domain. C2 domains fold
 vation, but all have a common fold, which is electrostatically polarized. PH domains also have diverse functions. They are
encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS o
mbrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane p
 -protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, wh
roduction of ATP by a process, which is catalyzed by water-soluble enzymes in the cytosol; not involving membranes and
 shape (cortexillins), and signaling proteins (Vav).
 f a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to in
 f a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to in
 f a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to in
 f a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to in
 f a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to in
 f a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to in
Ub). UCH-L1, in dimeric form, has additional enzymatic activity as a ubiquitin ligase. It is highly abundant in the brain, con
toplasmic domain. The N-terminal domains of the alpha and beta subunits associate to form the integrin headpiece, which
minal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in pro
minal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in pro
minal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in pro
m being translated. S15 has a predominantly alpha-helical fold that is highly structured except for the N-terminal alpha he
 py numbers.
 py numbers.

py numbers.
py numbers.
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
ogous domains occur in related receptors, including the very low-density      lipoprotein receptor and the LDL receptor-related
criptional coregulator by directly interacting with other nuclear receptors   through its AF-2 motif. The closest relative of SH




ant roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domai

 s. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, w
Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate t
 proto-,and FAT-family cadherin, desmocollin, and desmoglein, exists as monomers or dimers (hetero- and homo-); two co
 proto-,and FAT-family cadherin, desmocollin, and desmoglein, exists as monomers or dimers (hetero- and homo-); two co
 fic gene regulation. The structure contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged hel
 ) to generate two important second messengers in eukaryotic signal transduction cascades, Inositol 1,4,5-trisphosphate
 terminal PH domain followed by a series of EF hands, a catalytic TIM barrel and a C-terminal C2 domain. C2 domains fold
py numbers.
ning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like dom
eats are stacked in a superhelical arrangement; this alignment contains 4 consecutive repeats.
erved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is t
utic drugs, environmental toxins and products of oxidative stress. The GST fold contains an N-terminal thioredoxin-fold dom
utic drugs, environmental toxins and products of oxidative stress. The GST fold contains an N-terminal TRX-fold domain an

 ane, but few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions i
specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the dom
chain and a small chain called the beta2 microglobulin. The alpha chain contains three extracellular domains, two of which
remodeling RSC complex. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the
ins are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact s
al tails of Sm proteins. The SMN protein is linked to spinal muscular atrophy. Another example is the tandem tudor domain




membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subun
tified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His
kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase. PKs make up a large family of serine/threonine kinase
CSAGxGRxG. Characterized as either transmembrane, receptor-like or non-transmembrane (soluble) PTPs. Receptor-like PT


 n complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory func
e clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions re
at present according to the organization of their signature motifs; all helicases share the ability to unwind nucleic acid dup

d secretory granules. It functions as a Ca2+ sensor for fast exocytosis as do synaptotagmins 5, 6, and 10. It is distinguish
CSAGxGRxG. Characterized as either transmembrane, receptor-like or non-transmembrane (soluble) PTPs. Receptor-like PT
CSAGxGRxG. Characterized as either transmembrane, receptor-like or non-transmembrane (soluble) PTPs. Receptor-like PT
py numbers.
 substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are
 proto-,and FAT-family cadherin, desmocollin, and desmoglein, exists as monomers or dimers (hetero- and homo-); two co
 proto-,and FAT-family cadherin, desmocollin, and desmoglein, exists as monomers or dimers (hetero- and homo-); two co
 proto-,and FAT-family cadherin, desmocollin, and desmoglein, exists as monomers or dimers (hetero- and homo-); two co
 proto-,and FAT-family cadherin, desmocollin, and desmoglein, exists as monomers or dimers (hetero- and homo-); two co
 nd membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant featu
 s SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of th
 s SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of th
 s SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of th
 loid and its Xenopus homologue xolloid cleave and inactivate Sog and chordin, respectively, which are inhibitors of Dpp (t

 d by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate ge
rotein is modular consisting mainly of repetitive IG-like and fibronectin type III (FnIII) domains, and has a muscle-type sp
ning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like dom
ning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like dom
ning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like dom
ning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like dom
ning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like dom
 nd membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant featu
omyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorha
omyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorha




axis, and pericardial edema in others. The presence of calcium-dependent lipid-binding domains in C2cd3 suggests a poten
 substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are
py numbers.
d in disorders of cholesterol transport and high-density lipoprotein (HDL) biosynthesis. The ABCA4 (ABCR) protein transpo
d in disorders of cholesterol transport and high-density lipoprotein (HDL) biosynthesis. The ABCA4 (ABCR) protein transpo
ame WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bin
  via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown


 ant roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domai
rger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminogly
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
 shape (cortexillins), and signaling proteins (Vav).
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
nge in an antiparallel manner to form dimers; the repeats   are defined by a characteristic tryptophan (W) residue in helix A
 shape (cortexillins), and signaling proteins (Vav).
nge in an antiparallel manner to form dimers; the repeats   are   defined   by   a   characteristic   tryptophan   (W)   residue   in   helix   A
nge in an antiparallel manner to form dimers; the repeats   are   defined   by   a   characteristic   tryptophan   (W)   residue   in   helix   A
nge in an antiparallel manner to form dimers; the repeats   are   defined   by   a   characteristic   tryptophan   (W)   residue   in   helix   A
nge in an antiparallel manner to form dimers; the repeats   are   defined   by   a   characteristic   tryptophan   (W)   residue   in   helix   A
nge in an antiparallel manner to form dimers; the repeats   are   defined   by   a   characteristic   tryptophan   (W)   residue   in   helix   A
nge in an antiparallel manner to form dimers; the repeats   are   defined   by   a   characteristic   tryptophan   (W)   residue   in   helix   A
nge in an antiparallel manner to form dimers; the repeats   are   defined   by   a   characteristic   tryptophan   (W)   residue   in   helix   A
nge in an antiparallel manner to form dimers; the repeats   are   defined   by   a   characteristic   tryptophan   (W)   residue   in   helix   A

ct three helix bundle, has a conserved GFP-loop and the proline is thought to be critical for binding. The UBA domain is dis
 ion and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present pr
 ion and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present pr
 ion and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present pr
ay. UDP-GlcNAc is an essential metabolite that serves as the biosynthetic precursor of many glycoproteins and mucopolysa
 proto-,and FAT-family cadherin, desmocollin, and desmoglein, exists as monomers or dimers (hetero- and homo-); two co
 proto-,and FAT-family cadherin, desmocollin, and desmoglein, exists as monomers or dimers (hetero- and homo-); two co
 proto-,and FAT-family cadherin, desmocollin, and desmoglein, exists as monomers or dimers (hetero- and homo-); two co
 proto-,and FAT-family cadherin, desmocollin, and desmoglein, exists as monomers or dimers (hetero- and homo-); two co
 proto-,and FAT-family cadherin, desmocollin, and desmoglein, exists as monomers or dimers (hetero- and homo-); two co
ves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the dinuclear ferroxidase centers, and
yme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP b
and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
yme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP b




  calpain involving electrostatic interactions with subdomain II. Proposed to mediate calpain's interaction with phospholipid




mbrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane p




 in (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in sev
membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits
 be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. Th
 be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. Th
  n as PalA) from Saccharomyces cerevisiae, mammalian His-Domain type N23 protein tyrosine phosphatase (HD-PTP, also
 nstant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recog
 tes the YAP/Yorkie (Yki) transcription coactivator. The FERM domain proteins Merlin (Mer) and Expanded (Ex) are part of t
chain and a small chain called the beta2 microglobulin. The alpha chain contains three extracellular domains, two of which
 romolar range), are stable in their absence and have a high turnover GTPase. In addition to binding GDP/GTP, they have

 little sequence conservation, but all have a common fold, which is electrostatically polarized. PH domains also have divers
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
 shape (cortexillins), and signaling proteins (Vav).
 shape (cortexillins), and signaling proteins (Vav).
nge in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A
entiation through mediation of cell adhesion molecules.
entiation through mediation of cell adhesion molecules.
  which is phosphorylated in the reaction. This subgroup contains cofactor-dependent and cofactor-independent phosphogly
  which is phosphorylated in the reaction. This subgroup contains cofactor-dependent and cofactor-independent phosphogly
 ant roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domai
 ant roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domai
Ub). UCH-L1, in dimeric form, has additional enzymatic activity as a ubiquitin ligase. It is highly abundant in the brain, con

nd in a number of proteins, some of which have been implicated in intracellular trafficking and sorting. The VHS domain o

 ant roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domai
entiation through mediation of cell adhesion molecules.
entiation through mediation of cell adhesion molecules.
entiation through mediation of cell adhesion molecules.
entiation through mediation of cell adhesion molecules.
idermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable rangi
idermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable rangi
entiation through mediation of cell adhesion molecules.
 f a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to in
 f a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to in
 names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Ther
urin cleaves cell surface vasoactive peptides and proteins involved in cardiovascular tissue remodeling in the TGN, at cell s




rs, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide
 f a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to in
e are also other E2s which form thiol-ester linkages without the use of E3s as well as several UBC homologs (TSG101, Mm
main has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent molecula

  to generate two important second messengers in eukaryotic signal transduction cascades, Inositol 1,4,5-trisphosphate (
terminal PH domain followed by a series of EF hands, a catalytic TIM barrel and a C-terminal C2 domain. C2 domains fold
vation, but all have a common fold, which is electrostatically polarized. PH domains also have diverse functions. They are
aling, cell fusion, and cell-cell interactions.
 e membrane and folds back into the protein. A general feature of Arf1-5 signaling may be the cooperation of two Arfs at t
ntracellular or transmembrane. Several structures of PGRPs are known in insects and mammals, some bound with substrat
ntracellular or transmembrane. Several structures of PGRPs are known in insects and mammals, some bound with substrat
s have a deep hydrophobic ligand-binding pocket. STARD1 has a high affinity for cholesterol. It can reduce macrophage lip

as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian c

he   IPT_PCSR   domain   present   preceeded   by   SEMA   (semaphorin)   and   PSI   (plexin,   semaphorin,   integrin)   domains.
he   IPT_PCSR   domain   present   preceeded   by   SEMA   (semaphorin)   and   PSI   (plexin,   semaphorin,   integrin)   domains.
he   IPT_PCSR   domain   present   preceeded   by   SEMA   (semaphorin)   and   PSI   (plexin,   semaphorin,   integrin)   domains.
he   IPT_PCSR   domain   present   preceeded   by   SEMA   (semaphorin)   and   PSI   (plexin,   semaphorin,   integrin)   domains.
he   IPT_PCSR   domain   present   preceeded   by   SEMA   (semaphorin)   and   PSI   (plexin,   semaphorin,   integrin)   domains.
he   IPT_PCSR   domain   present   preceeded   by   SEMA   (semaphorin)   and   PSI   (plexin,   semaphorin,   integrin)   domains.
he   IPT_PCSR   domain   present   preceeded   by   SEMA   (semaphorin)   and   PSI   (plexin,   semaphorin,   integrin)   domains.
he   IPT_PCSR   domain   present   preceeded   by   SEMA   (semaphorin)   and   PSI   (plexin,   semaphorin,   integrin)   domains.
he   IPT_PCSR   domain   present   preceeded   by   SEMA   (semaphorin)   and   PSI   (plexin,   semaphorin,   integrin)   domains.




 PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, includin

 nd transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a
 hosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-gly
   Inositol 1,4,5-trisphosphate (InsP3) and diacylglycerol (DAG). InsP3 triggers inflow of calcium from intracellular stores, w
 al C2 domain. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Typ
 ve diverse functions. They are often involved in targeting proteins to the plasma membrane, but few display strong specif
 MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and
ns (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and
alcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
  not involving membranes and ion gradients.

  ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging
  ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging
  ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging
  ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging
  ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging
  ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging
 ghly abundant in the brain, constituting up to 2% of total protein, and is expressed exclusively in neurons and testes. Abn
m the integrin headpiece, which contains the ligand binding site, whereas the C-terminal segments traverse the plasma me
 ct to PDZ domains found in proteases.
 ct to PDZ domains found in proteases.
 ct to PDZ domains found in proteases.
 ept for the N-terminal alpha helix.
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
or and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated,
motif. The closest relative of SHP is DAX1 and they can form heterodimer. SHP is an orphan receptor, lacking an identified




 nd transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a

  transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directio
pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, a
  rs (hetero- and homo-); two copies of the repeat are present here
  rs (hetero- and homo-); two copies of the repeat are present here
 ion, hence the term winged helix.
s, Inositol 1,4,5-trisphosphate (InsP3) and diacylglycerol (DAG). InsP3 triggers inflow of calcium from intracellular stores,
 al C2 domain. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Typ

dhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.

 stic motif of this family and is thus known as the ABC signature sequence.
 N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between th
 N-terminal TRX-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two

d by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domain
ns in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signa
acellular domains, two of which fold together to form the peptide-binding cleft (alpha1 and alpha2), and one which has an
 anscriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH doma
s. Bromodomains can interact specifically with acetylated lysine.
 ple is the tandem tudor domains of 53BP1, which bind to histone H4 specifically dimethylated at Lys20 (H4-K20me2). 53B




mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the
 lytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure.
amily of serine/threonine kinases, protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine
 (soluble) PTPs. Receptor-like PTP domains tend to occur in two copies in the cytoplasmic region of the transmembrane pro


  with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleto
igands for the two metal ions required for catalysis. RNase D is involved in the 3'-end processing of tRNA precursors. RNas
bility to unwind nucleic acid duplexes with a distinct directional polarity; they utilize the free energy from nucleoside tripho

ns 5, 6, and 10. It is distinguished from the other synaptotagmins by having an N-glycosylated N-terminus. Synaptotagmi
(soluble) PTPs. Receptor-like PTP domains tend to occur in two copies in the cytoplasmic region of the transmembrane pro
(soluble) PTPs. Receptor-like PTP domains tend to occur in two copies in the cytoplasmic region of the transmembrane pro

 . Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase
 rs (hetero- and homo-); two copies of the repeat are present here
 rs (hetero- and homo-); two copies of the repeat are present here
 rs (hetero- and homo-); two copies of the repeat are present here
 rs (hetero- and homo-); two copies of the repeat are present here
re protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptopha
entified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that
entified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that
entified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that
y, which are inhibitors of Dpp (the Drosophila decapentaplegic gene product) and its homologue BMP4, involved in dorso-v

 Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been sho
ains, and has a muscle-type specific expression pattern. M-protein is present in fast fibers.
dhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
dhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
dhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
dhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
dhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
re protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptopha
 proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This fam
 proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This fam




mains in C2cd3 suggests a potential role in vesicular transport. C2cd3 is also an interesting candidate for ciliopathy becaus
 . Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase

e ABCA4 (ABCR) protein transports vitamin A derivatives in the outer segments of photoreceptor cells, and therefore, perfo
e ABCA4 (ABCR) protein transports vitamin A derivatives in the outer segments of photoreceptor cells, and therefore, perfo
 tform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where eac
DPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological fun


 nd transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a
 kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. MOK, also calle
yptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; tw

yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; tw

yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw

 binding. The UBA domain is distinct from the conserved three helical domain seen in the N-terminus of EF-TS and eukaryo
he IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
he IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
he IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.
y glycoproteins and mucopolysaccharides. AGM1 is a member of the alpha-D-phosphohexomutase superfamily, which cata
 rs (hetero- and homo-); two copies of the repeat are present here
 rs (hetero- and homo-); two copies of the repeat are present here
 rs (hetero- and homo-); two copies of the repeat are present here
 rs (hetero- and homo-); two copies of the repeat are present here
 rs (hetero- and homo-); two copies of the repeat are present here
uclear ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite; the protein shell ca
tifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and r
end of its tRNA.
tifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and r




n's interaction with phospholipids and translocation to cytoplasmic/nuclear membranes. CD includes subdomain III of typic




ns (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and




en shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resemb
mmalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the rem
as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian c
as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian c
 ine phosphatase (HD-PTP, also known as PTPN23), and related domains. Alix, also known as apoptosis-linked gene-2 inter
 a TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) m
and Expanded (Ex) are part of the upstream regulation controlling pathway mechanism. Kibra colocalizes and associates w
acellular domains, two of which fold together to form the peptide-binding cleft (alpha1 and alpha2), and one which has an
 o binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but a

d. PH domains also have diverse functions. PH domains are often involved in targeting proteins to the plasma membrane
yptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; tw
yptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; tw
yptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw
yptophan   (W)   residue   in   helix   A   and   a   leucine   (L)   at   the   carboxyl   end   of   helix   C   and   separated   by   a   linker   of   5   residues;   tw


yptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; tw


 ofactor-independent phosphoglycerate mutases (dPGM, and BPGM respectively), fructose-2,6-bisphosphatase (F26BP)ase,
 ofactor-independent phosphoglycerate mutases (dPGM, and BPGM respectively), fructose-2,6-bisphosphatase (F26BP)ase,
 nd transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a
 nd transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a
 ghly abundant in the brain, constituting up to 2% of total protein, and is expressed exclusively in neurons and testes. Abn

 and sorting. The VHS domain of the Tom1 protein is essential for the negative regulation of Interleukin-1 and Tumor Necro

 nd transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a




 aminins is highly variable ranging from 3 up to 22 copies
 aminins is highly variable ranging from 3 up to 22 copies

 ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging
 ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging
an in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determine
 emodeling in the TGN, at cell surface, or in endosomes but rarely in the ER. Furin also plays a key role in blood pressure




 as superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regu
 ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging
al UBC homologs (TSG101, Mms2, Croc-1 and similar proteins) which lack the active site cysteine essential for ubiquitinati
microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. In this grou

   Inositol 1,4,5-trisphosphate (InsP3) and diacylglycerol (DAG). InsP3 triggers inflow of calcium from intracellular stores, w
 al C2 domain. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Typ
 ve diverse functions. They are often involved in targeting proteins to the plasma membrane, but few display strong specif
 the cooperation of two Arfs at the same site. Arfs1-5 are generally considered to be interchangeable in function and locat
mals, some bound with substrates like Muramyl Tripeptide (MTP) or Tracheal Cytotoxin (TCT). The substrate binding site is
mals, some bound with substrates like Muramyl Tripeptide (MTP) or Tracheal Cytotoxin (TCT). The substrate binding site is
 l. It can reduce macrophage lipid content and inflammatory status. It plays an essential role in steroidogenic tissues: tran

 in turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in th

 n,   integrin)   domains.
 n,   integrin)   domains.
 n,   integrin)   domains.
 n,   integrin)   domains.
 n,   integrin)   domains.
 n,   integrin)   domains.
 n,   integrin)   domains.
 n,   integrin)   domains.
 n,   integrin)   domains.




ene-silencing pathways, including RNA interference, the Piwi and Dicer families. PAZ functions as a nucleic acid binding do

ox, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B-
ase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.
 cium from intracellular stores, while DAG, together with calcium, activates protein kinase C, which goes on to phosphoryla
 l arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands
 e, but few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in t
 urface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group
n meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both
ndem repeat arrangements.


number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the c
number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the c
number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the c
number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the c
number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the c
number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the c
vely in neurons and testes. Abnormal expression of UCH-L1 has been shown to correlate with several forms of cancer, incl
gments traverse the plasma membrane and mediate interaction with the cytoskeleton and with signalling proteins.The VW
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
hich are functionally unrelated, such as    the   C9   component   of   complement;   the   binding   of   calcium   is   required   for   in   vitro   for
n receptor, lacking an identified ligand.




ox, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B-

the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in l
ly than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed




alcium from intracellular stores, while DAG, together with calcium, activates protein kinase C, which then phosphorylates o
 l arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands




site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occu
ated in a cleft between the two domains. Mammalian class Theta GSTs show poor GSH conjugating activity towards the sta

cross all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinsase
mains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, en
 alpha2), and one which has an Ig fold (alpha3). Peptide binding to class I molecules occurs in the endoplasmic reticulum
 f these instances the BAH domain mediates protein-protein interactions.

ted at Lys20 (H4-K20me2). 53BP1 is a key transducer of the DNA damage checkpoint signal.




 mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes,
e is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. Th
 that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation, abo
egion of the transmembrane proteins, only one copy may be active.


 vesicle trafficking, cytoskeleton rearrangement and, interact with a variety of proteins. Flotillins may play a role in the pr
essing of tRNA precursors. RNase D-like proteins in eukaryotes include yeast Rrp6p, human PM/Scl-100 and Drosophila me
e energy from nucleoside triphosphate hydrolysis to fuel their translocation along DNA, unwinding the duplex in the proces

ated N-terminus. Synaptotagmins 5, 6, and 10, members of class 3 synaptotagmins, are located primarily in the brain and
egion of the transmembrane proteins, only one copy may be active.
egion of the transmembrane proteins, only one copy may be active.

 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synap




wo beta-sheets with a tryptophan residue packed against the disulfide bond.
 to a binding site, implying that the orientation of the modules to each other is critical for function.
 to a binding site, implying that the orientation of the modules to each other is critical for function.
 to a binding site, implying that the orientation of the modules to each other is critical for function.
ogue BMP4, involved in dorso-ventral patterning.

al cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.




wo beta-sheets with a tryptophan residue packed against the disulfide bond.
nas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1
nas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1




 candidate for ciliopathy because of its orthology to certain cilia-related genetic disease loci on chromosome. The C2 doma
 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synap

 eptor cells, and therefore, performs a crucial step in the visual cycle. The ABCA genes are not present in yeast. However,
 eptor cells, and therefore, performs a crucial step in the visual cycle. The ABCA genes are not present in yeast. However,
e with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable
as a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid m


ox, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B-
sitide 3-kinase. MOK, also called Renal tumor antigen 1 (RAGE-1), is widely expressed and is enriched in testis, kidney, lu
ed by a linker of 5 residues; two copies of the repeat are present here

ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
 ed by a linker of 5 residues; two copies of the repeat are present here

 ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
 ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
 ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
 ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
 ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
 ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
 ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
 ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here

-terminus of EF-TS and eukaryotic NAC proteins.
n, integrin) domains.
n, integrin) domains.
n, integrin) domains.
mutase superfamily, which catalyzes the intramolecular phosphoryl transfer of sugar substrates. The alpha-D-phosphohexo




 errihydrite; the protein shell can hold up to 4500 iron atoms. In vertebrates, two types of chains (subunits) have been cha
 subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus preven

 subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus preven




 includes subdomain III of typical and atypical calpains.




n meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both




uence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-bin
 tochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, sub
 in turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in th
 in turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in th
as apoptosis-linked gene-2 interacting protein 1 (AIP1), is part of the ESCRT (Endosomal Sorting Complexes Required for T
compatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located
bra colocalizes and associates with Mer and Ex and is thought to transduce an extracellular signal via the SWH network. Th
 alpha2), and one which has an Ig fold (alpha3). Peptide binding to class I molecules occurs in the endoplasmic reticulum
 yze GTP not only to GDP, but also to GMP. Furthermore, two unique regions around the base and the phosphate-binding a

teins to the plasma membrane via lipid binding. PH domains are found in cellular signaling proteins such as serine/threoni
 ed by a linker of 5 residues; two copies of the repeat are present here
 ed by a linker of 5 residues; two copies of the repeat are present here
 ed by a linker of 5 residues; two copies of the repeat are present here
ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here
ed   by   a   linker   of   5   residues;   two   copies   of   the   repeat   are   present   here


ed by a linker of 5 residues; two copies of the repeat are present here


,6-bisphosphatase (F26BP)ase, Sts-1, SixA, and related proteins. Functions include roles in metabolism, signaling, or regu
,6-bisphosphatase (F26BP)ase, Sts-1, SixA, and related proteins. Functions include roles in metabolism, signaling, or regu
ox, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B-
ox, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B-
vely in neurons and testes. Abnormal expression of UCH-L1 has been shown to correlate with several forms of cancer, incl

f Interleukin-1 and Tumor Necrosis Factor-induced signaling pathways.

ox, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B-




number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the c
number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the c
on, and mu), which determine the type of immunoglobulin: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrate
ys a key role in blood pressure regulation though the activation of transforming growth factor (TGF)-beta. High specificity




expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regula
 number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the c
ysteine essential for ubiquitination and appear to function in DNA repair pathways which were omitted from the scope of th
 and in cell division. In this group the motor domain is found at the N-terminus (N-type). N-type kinesins are (+) end-dire

cium from intracellular stores, while DAG, together with calcium, activates protein kinase C, which goes on to phosphoryla
l arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands
e, but few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in t
hangeable in function and location, but some specific functions have been assigned. Arf1 localizes to the early/cis-Golgi, w
T). The substrate binding site is conserved in PGRP-LCx, PGRP-LE, and PGRP-Ialpha proteins. This family includes Zn-depe
T). The substrate binding site is conserved in PGRP-LCx, PGRP-LE, and PGRP-Ialpha proteins. This family includes Zn-depe
 e in steroidogenic tissues: transferring the steroid precursor, cholesterol, from the outer to the inner mitochondrial memb

 gest families of peptidases in the human genome.




ons as a nucleic acid binding domain, with a strong preference for single-stranded nucleic acids (RNA or DNA) or RNA duple

 s needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal

C, which goes on to phosphorylate other molecules, leading to altered cellular activity. Calcium is required for the catalysis
  N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide va
 y loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains.
 ntenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat glob
 t has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a G




side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety hete
side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety hete
side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety hete
side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety hete
side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety hete
side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety hete
th several forms of cancer, including several primary lung tumors, lung tumor cell lines, and colorectal cancers. Mutations
with signalling proteins.The VWA domains present in the alpha subunits of integrins seem to be a chordate specific radiatio
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the
alcium   is   required   for   in   vitro   formation   of   the   native   disulfide   isomer   and   is   necessary   in   establishing   and   maintaining   the




s needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal

ally 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydr
e thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying e




C, which then phosphorylates other molecules, leading to altered cellular activity. Calcium is required for the catalysis. PLC
N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide va




the hydrophobic substrate occupies a pocket in the C-terminal domain. Mammalian class Theta GSTs show poor GSH conju
ugating activity towards the standard substrates, CDNB and ethacrynic acid, differentiating them from other mammalian G

eonine kinase, tyrosine kinsases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associate
ses, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid asso
 s in the endoplasmic reticulum (ER) and involves both chaperones and dedicated factors to assist in peptide loading. Clas




me. Found only in eukaryotes, subunit VIa is expressed in two tissue-specific isoforms in mammals but not fish. VIa-H is
e to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to
of protein phosphorylation, about 95%, occurs on serine residues while only 1% occurs on tyrosine residues. Protein phos
otillins may play a role in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Park
 PM/Scl-100 and Drosophila melanogaster egalitarian (Egl) protein. WRN is a unique DNA helicase possessing exonuclease
winding the duplex in the process

cated primarily in the brain and localized to the active zone and plasma membrane. They is distinguished from the other s




 two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some




 on of these proteins.




 ypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzym
 ypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzym




 on chromosome. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can ad
 two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some

not present in yeast. However, evolutionary studies of ABCA genes indicate that they arose as transporters that subseque
not present in yeast. However, evolutionary studies of ABCA genes indicate that they arose as transporters that subseque
t; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence r
eroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in many organisms. FNR has an


 s needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal
 is enriched in testis, kidney, lung, and brain. It is expressed in approximately 50% of renal cell carcinomas (RCC) and is a
ates. The alpha-D-phosphohexomutases have four domains with a centrally located active site formed by four loops, one f




chains (subunits) have been characterized, H or M (fast) and L (slow), which differ in rates of iron uptake and mineralizatio
cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.

cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.




t has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a G




 nature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-termin
 . Found only in eukaryotes, subunit VIb is one of three mammalian subunits that lacks a transmembrane region. It is loca
gest families of peptidases in the human genome.
gest families of peptidases in the human genome.
orting Complexes Required for Transport) system, and participates in membrane remodeling processes, including the budd
igen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens; t
 signal via the SWH network. The apical scaffold machinery that contains Hpo, Wts, and Ex recruits Yki to the apical memb
 s in the endoplasmic reticulum (ER) and involves both chaperones and dedicated factors to assist in peptide loading. Clas
se and the phosphate-binding areas, the guanine and the phosphate caps, respectively, give the nucleotide-binding site a

proteins such as serine/threonine kinase, tyrosine kinsases, regulators of G-proteins, endocytotic GTPases, adaptors, as w
n metabolism, signaling, or regulation, for example, F26BPase affects glycolysis and gluconeogenesis through controlling th
n metabolism, signaling, or regulation, for example, F26BPase affects glycolysis and gluconeogenesis through controlling th
 s needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal
 s needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal
 th several forms of cancer, including several primary lung tumors, lung tumor cell lines, and colorectal cancers. Mutations




 s needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal




side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety hete
side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety hete
espectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate w
 or (TGF)-beta. High specificity is seen for cleavage after dibasic (Lys-Arg or Arg-Arg) or multiple basic residues in protein




Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microt
side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety hete
ere omitted from the scope of this CD.
 -type kinesins are (+) end-directed motors, i.e. they transport cargo towards the (+) end of the microtubule. Kinesin moto

C, which goes on to phosphorylate other molecules, leading to altered cellular activity. Calcium is required for the catalysis
  N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide va
 y loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains.
ocalizes to the early/cis-Golgi, where it is activated by GBF1 and recruits the coat protein COPI. It also localizes to the tran
s. This family includes Zn-dependent N-Acetylmuramoyl-L-alanine Amidase, EC:3.5.1.28. This enzyme cleaves the amide
s. This family includes Zn-dependent N-Acetylmuramoyl-L-alanine Amidase, EC:3.5.1.28. This enzyme cleaves the amide
 the inner mitochondrial membrane, across the aqueous space. Mutations in the gene encoding STARD1/StAR can cause li




cids (RNA or DNA) or RNA duplexes with single-stranded 3' overhangs. It has been suggested that the PAZ domain provide

omains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain

um is required for the catalysis. PLC-beta represents a class of mammalian PI-PLC that has an N-terminal pleckstrin homo
 ng modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular
ss all PH domains.
  protein in bovine milk-fat globule membrane (MFGM).
eceptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA




omain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alterna
omain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alterna
omain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alterna
omain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alterna
omain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alterna
omain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alterna
 d colorectal cancers. Mutations in the UCH-L1 gene have been linked to susceptibility to and protection from Parkinson's d
 o be a chordate specific radiation of the gene family being found only in vertebrates. They mediate protein-protein interac
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure
 tablishing   and   maintaining   the   modular   structure




omains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain

 elices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and m
which may explain the varying efficiency for different template nucleotides.




 is required for the catalysis. PLC-delta represents a class of mammalian PI-PLC that has an N-terminal pleckstrin homolog
  ng modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular




heta GSTs show poor GSH conjugating activity towards the standard substrates, CDNB and ethacrynic acid, differentiating
 them from other mammalian GSTs. GSTT1-1 shows similar cataytic activity as bacterial DCM dehalogenase, catalyzing th

as well as cytoskeletal associated molecules and in lipid associated enzymes.
ated molecules and in lipid associated enzymes.
 assist in peptide loading. Class I MHC molecules are expressed on most nucleated cells.




mammals but not fish. VIa-H is the heart and skeletal muscle isoform; VIa-L is the liver or non-muscle isoform. Mammalia
wing the lipid substrate access to the active site.
  tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes a
 enerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis.
helicase possessing exonuclease activity. Mutation in the WRN gene is implicated in Werner syndrome, a disease associated


s distinguished from the other synaptotagmins by having disulfide bonds at its N-terminus. Synaptotagmin 6 also regulat




cluding RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2




family. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carbox
family. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carbox




nded beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation
 cluding RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2

e as transporters that subsequently duplicated and that certain sets of ABCA genes were lost in different eukaryotic lineag
e as transporters that subsequently duplicated and that certain sets of ABCA genes were lost in different eukaryotic lineag
ization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the la
n many organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) fla


omains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain
 l cell carcinomas (RCC) and is a potential target for immunotherapy. MOK is stabilized by its association with the HSP90 m
site formed by four loops, one from each domain. All four domains are included in this alignment model.




of iron uptake and mineralization. Fe(II) oxidation in the H/M subunits take place initially at the ferroxidase center, a carb




eceptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA




ology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show s
 ansmembrane region. It is located on the cytosolic side of the membrane and helps form the dimer interface with the corr


 g processes, including the budding of enveloped viruses, vesicle budding inside late endosomal multivesicular bodies (MVB
ognize intact protein antigens; they recognize proteins antigens directly and without antigen processing, and MHC indepen
  recruits Yki to the apical membrane facilitating its inhibitory phosphorlyation by Wts. Since Kibra associates with Ex and
   assist in peptide loading. Class I MHC molecules are expressed on most nucleated cells.
 e the nucleotide-binding site a unique appearance not found in the canonical GTP-binding proteins. The phosphate cap, w

cytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
eogenesis through controlling the concentration of F26BP; BPGM controls the concentration of 2,3-BPG (the main allosteric
eogenesis through controlling the concentration of F26BP; BPGM controls the concentration of 2,3-BPG (the main allosteric
omains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain
omains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain
 d colorectal cancers. Mutations in the UCH-L1 gene have been linked to susceptibility to and protection from Parkinson's d




omains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain




omain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alterna
omain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alterna
 lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu hea
ultiple basic residues in protein convertases. There is also strong sequence conservation.




ytoplasmic transport and microtubule organization. The GTP translation factor family regulate initiation, elongation, termin
omain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alterna

of the microtubule. Kinesin motor domains hydrolyze ATP at a rate of about 80 per second, and move along the microtubul

um is required for the catalysis. PLC-beta represents a class of mammalian PI-PLC that has an N-terminal pleckstrin homo
 ng modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular
ss all PH domains.
 OPI. It also localizes to the trans-Golgi network (TGN), where it is activated by BIG1/BIG2 and recruits the AP1, AP3, AP4
This enzyme cleaves the amide bond between N-acetylmuramoyl and L-amino acids, preferentially D-lactyl-L-Ala, in bacter
This enzyme cleaves the amide bond between N-acetylmuramoyl and L-amino acids, preferentially D-lactyl-L-Ala, in bacter
 ding STARD1/StAR can cause lipid congenital adrenal hyperplasia (CAH), an autosomal recessive disorder characterized by




ed that the PAZ domain provides a unique mode for the recognition of the two 3'-terminal nucleotides in single-stranded n

. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a

  an N-terminal pleckstrin homology (PH) domain, an array of EF hands, a PLC catalytic core domain, a C2 domain, and a u
olyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a s


nic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.




plicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).
plicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).
plicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).
plicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).
plicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).
plicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).
d protection from Parkinson's disease (PD); dysfunction of the hydrolase activity can lead to an accumulation of alpha-syn
mediate protein-protein interactions.
. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a

s display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structu




  N-terminal pleckstrin homology (PH) domain, an array of EF hands, a PLC catalytic core domain, and a C-terminal C2 dom
olyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a s




 ethacrynic acid, differentiating them from other mammalian GSTs. GSTT1-1 shows similar cataytic activity as bacterial DC
CM dehalogenase, catalyzing the GSH-dependent hydrolytic dehalogenation of dihalomethanes. This is an essential proces




non-muscle isoform. Mammalian VIa-H induces a slip in CcO (decrease in proton/electron stoichiometry) at high intramito

lar proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often f
d metastasis.
 syndrome, a disease associated with premature aging and increased predisposition to cancer. Yeast Rrp6p and the human


  Synaptotagmin 6 also regulates the acrosome reaction, a unique Ca2+-regulated exocytosis, in sperm. Synaptotagmin 9




y have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily asparta




r with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nuc
r with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nuc




ished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent me
y have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily asparta

 st in different eukaryotic lineages.
 st in different eukaryotic lineages.
  strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to creat
discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N


. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a
ts association with the HSP90 molecular chaperone. It is induced by the transcription factor Cdx2 and may be involved in r
nment model.




 t the ferroxidase center, a carboxylate-bridged diiron center, located within the subunit four-helix bundle. In a complemen




nic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.




whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as
he dimer interface with the corresponding subunit on the other monomer complex.


 mal multivesicular bodies (MVBs), the abscission reactions of mammalian cell division, and in apoptosis. The Alix V-domai
n processing, and MHC independently of the bound peptide.
e Kibra associates with Ex and is apically located it is hypothesized that KIBRA is part of the scaffold, helps in the Hpo/Wts

proteins. The phosphate cap, which constitutes the region analogous to switch I, completely shields the phosphate-binding

 ed enzymes.
  of 2,3-BPG (the main allosteric effector of hemoglobin in human blood cells); human Sts-1 is a T-cell regulator; Escherich
  of 2,3-BPG (the main allosteric effector of hemoglobin in human blood cells); human Sts-1 is a T-cell regulator; Escherich
 . Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a
 . Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a
  d protection from Parkinson's disease (PD); dysfunction of the hydrolase activity can lead to an accumulation of alpha-syn




 . Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a




 plicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).
 plicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).
mma, delta, epsilon, and mu heavy chains.




 te initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, spo
 plicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).

 and move along the microtubule at a speed of about 6400 Angstroms per second. To achieve that, kinesin head groups wo

  an N-terminal pleckstrin homology (PH) domain, an array of EF hands, a PLC catalytic core domain, a C2 domain, and a u
olyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a s
 and recruits the AP1, AP3, AP4, and GGA proteins. Humans, but not rodents and other lower eukaryotes, lack Arf2. Hum
entially D-lactyl-L-Ala, in bacterial cell walls. The structure for the bacteriophage T7 lysozyme shows that two of the conse
entially D-lactyl-L-Ala, in bacterial cell walls. The structure for the bacteriophage T7 lysozyme shows that two of the conse
essive disorder characterized by a steroid synthesis deficiency and an accumulation of cholesterol in the adrenal glands an




nucleotides in single-stranded nucleic acids and buries the 3' OH group, and that it might recognize characteristic 3' overh

rization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepre

e domain, a C2 domain, and a unique C-terminal coiled-coil (CT) domain necessary for homodimerization. The PLC catalyti
uction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain


ons with axon-rich region.




nucleoproteins (snRNPs).
nucleoproteins (snRNPs).
nucleoproteins (snRNPs).
nucleoproteins (snRNPs).
nucleoproteins (snRNPs).
nucleoproteins (snRNPs).
 o an accumulation of alpha-synuclein, which is linked to Parkinson's disease (PD), while accumulation of neurofibrillary tan
rization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepre

n kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY




omain, and a C-terminal C2 domain. This CD corresponds to the catalytic domain which is a TIM barrel with two highly con
uction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain




cataytic activity as bacterial DCM dehalogenase, catalyzing the GSH-dependent hydrolytic dehalogenation of dihalometha
nes. This is an essential process in methylotrophic bacteria to enable them to use chloromethane and DCM as sole carbon




stoichiometry) at high intramitochondrial ATP/ADP ratios, while VIa-L induces a permanent slip in CcO, depending on the p

se to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a sec
cer. Yeast Rrp6p and the human Polymyositis/scleroderma autoantigen 100kDa (PM/Scl-100) are exosome-associated prot


sis, in sperm. Synaptotagmin 9, a class 5 synaptotagmins, is located in the brain and localized to the synaptic vesicles. It




rged residues, primarily aspartates, that serve as ligands for calcium ions.




wo-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are
wo-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are




 mains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholip
rged residues, primarily aspartates, that serve as ligands for calcium ions.




 f the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propell
e NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin


rization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepre
 Cdx2 and may be involved in regulating intestinal epithelial development and differentiation.
ur-helix bundle. In a complementary role, negatively charged residues on the protein shell inner surface of




ons with axon-rich region.




cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly




 in apoptosis. The Alix V-domain is a dimerization domain, and contains a binding site, partially conserved in the V_Alix_li

e scaffold, helps in the Hpo/Wts complex, and helps recruit Yki for inactivation that promotes SWH pathway activity. Kibra

 y shields the phosphate-binding site from solvent such that a potential GTPase-activating protein (GAP) cannot approach.
 is a T-cell regulator; Escherichia coli Six A participates in the ArcB-dependent His-to-Asp phosphorelay signaling system.
 is a T-cell regulator; Escherichia coli Six A participates in the ArcB-dependent His-to-Asp phosphorelay signaling system.
rization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepre
rization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepre
o an accumulation of alpha-synuclein, which is linked to Parkinson's disease (PD), while accumulation of neurofibrillary tan




rization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepre




nucleoproteins (snRNPs).
nucleoproteins (snRNPs).




 mily regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the
nucleoproteins (snRNPs).

ve that, kinesin head groups work in pairs. Upon replacing ADP with ATP, a kinesin motor domain increases its affinity for

e domain, a C2 domain, and a unique C-terminal coiled-coil (CT) domain necessary for homodimerization. The PLC catalyti
uction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain
wer eukaryotes, lack Arf2. Hum
me shows that two of the conserved histidines and a cystei
me shows that two of the conserved histidines and a cystei
esterol in the adrenal glands and the gonads.




 ecognize characteristic 3' overhangs in siRN

 ption through recruiting corepressors. A key mechanism a

modimerization. The PLC catalytic core domain is
 afficking proteins which contain at least two C2 domai




 cumulation of neurofibrillary tangles is
ption through recruiting corepressors. A key mechanism a

-3-phosphate transporter), LacY (lacto




 TIM barrel with two highly conserved regions
afficking proteins which contain at least two C2 domai




 dehalogenation of dihalomethanes. This is an essential pr
ethane and DCM as sole carbon and energy sources. The pre




 slip in CcO, depending on the presence of cardiolipin an

which one kinase activates a second kinas
0) are exosome-associated proteins involved in the degradat


ized to the synaptic vesicles. It is thought to be a C




these carboxylate residues are conserved.
these carboxylate residues are conserved.




ances including bind phospholipids, inositol polyp




nd bottom surface of the propeller are propos
 in flavoenzymes) or use flavin as a substrat


ption through recruiting corepressors. A key mechanism a
nner surface of




 and SMC5 with SMC6 (formerly known as Rad18).




tially conserved in the V_Alix_like superfamily, for the retro

es SWH pathway activity. Kibra contain

protein (GAP) cannot approach.
phosphorelay signaling system. Deficiency and m
phosphorelay signaling system. Deficiency and m
ption through recruiting corepressors. A key mechanism a
ption through recruiting corepressors. A key mechanism a
cumulation of neurofibrillary tangles is




 ption through recruiting corepressors. A key mechanism a




mily are identified by the


 omain increases its affinity for microtubule bi

modimerization. The PLC catalytic core domain is
 afficking proteins which contain at least two C2 domai
QM2-qcdsearch-74C25151AD4CE0FE-6D9B50D950C9C5AA

Query    gi accession no.
Q#41     gi|126294328
Q#58     gi|126334034
Q#59     gi|12845693
Q#60     gi|12846064
Q#60     gi|12846064
Q#61     gi|12851862
Q#63     gi|12853685
Q#64     gi|12853685
Q#176    gi|194373989
Q#176    gi|194373989
Q#176    gi|26333111
Q#176    gi|26336067
Q#176    gi|26336067
Q#176    gi|26336067
Q#176    gi|26348877
Q#176    gi|26348877
Q#181    gi|281337739
Q#181    gi|281337739
Q#182    gi|281337747
Q#182    gi|281337747
Q#183    gi|281337747
Q#184    gi|281353154
Q#184    gi|281353154
Q#263    gi|34533800
D4CE0FE-6D9B50D950C9C5AA

        Protein short name
         hypothetical protein
         hypothetical protein
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         unnamed protein product
         hypothetical protein PANDA_003017
         hypothetical protein PANDA_003017
         hypothetical protein PANDA_007621
         hypothetical protein PANDA_007621
         hypothetical protein PANDA_007621
         hypothetical protein PANDA_003347
         hypothetical protein PANDA_003347
         unnamed protein product
Domain short name             Definition
KRAB_A-box                    KRAB (Kruppel-associated box) domain -A box.; The KRAB do
vWA_integrins_alpha_subunit   Integrins are a class of adhesion receptors that link the extrac
Ribosomal_S15p_S13e           Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds t
EFh                           EF-hand, calcium binding motif; A diverse superfamily of calc
EFh                           EF-hand, calcium binding motif; A diverse superfamily of calc
SEC14                         Sec14p-like lipid-binding domain. Found in secretory proteins
EFh                           EF-hand, calcium binding motif; A diverse superfamily of calc
EFh                           EF-hand, calcium binding motif; A diverse superfamily of calc
PTPc                          Protein tyrosine phosphatases (PTP) catalyze the dephosphor
PTPc                          Protein tyrosine phosphatases (PTP) catalyze the dephosphor
Ig                            Immunoglobulin domain; Ig: immunoglobulin (Ig) domain fou
CCP                           Complement control protein (CCP) modules (aka short consen
CCP                           Complement control protein (CCP) modules (aka short consen
CCP                           Complement control protein (CCP) modules (aka short consen
ZnMc_BMP1_TLD                 Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. B
CUB                           CUB domain; extracellular domain; present in proteins mostly
NT_PAP_TUTase                 Nucleotidyltransferase (NT) domain of poly(A) polymerases a
NT_PAP_TUTase                 Nucleotidyltransferase (NT) domain of poly(A) polymerases a
SH3                           Src homology 3 domains; SH3 domains bind to proline-rich li
SH3                           Src homology 3 domains; SH3 domains bind to proline-rich li
SH3                           Src homology 3 domains; SH3 domains bind to proline-rich li
C2_C2cd3                      C2 domain found in C2 calcium-dependent domain containing
C2                            C2 domain; The C2 domain was first identified in PKC. C2 dom
C2_Kibra                      C2 domain found in Human protein Kibra; Kibra is thought to
main -A box.; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs
eceptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll s
c)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and
 diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 act
 diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 act
Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated pro
 diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 act
 diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 act
P) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction
P) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction
unoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a com
 modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complemen
 modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complemen
 modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complemen
BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in
; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
n of poly(A) polymerases and terminal uridylyl transferases.; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synth
n of poly(A) polymerases and terminal uridylyl transferases.; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synth
mains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in th
mains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in th
mains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in th
 pendent domain containing 3 (C2cd3) proteins; C2cd3 is a novel C2 domain-containing protein specific to vertebrates. C2
 st identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I a
n Kibra; Kibra is thought to be a regulator of the Salvador (Sav)/Warts (Wts)/Hippo (Hpo) (SWH) signaling network, which
of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional
ctor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta s
 he small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole
his alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand mot
his alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand mot
 14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known
his alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand mot
his alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand mot
 ine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylate
 ine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylate
group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are compone
 eral proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complemen
 eral proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complemen
 eral proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complemen
alloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural p
s, plants and yeast.
atalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup inc
atalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup inc
xP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localizatio
xP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localizatio
xP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localizatio
 tein specific to vertebrates. C2cd3 functions in regulator of cilia formation, Hedgehog signaling, and mouse embryonic de
uctural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta s
 SWH) signaling network, which limits tissue growth by inhibiting cell proliferation and promoting apoptosis. The core of th
 largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown
consist of an alpha and a beta sub-unit. Each sub-unit has a large extracellular portion, a single transmembrane segment
 nt in the assembly of the whole ribosome. S15 also plays an important autoregulatory role by binding and preventing its o
 nal change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pair
 nal change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pair
 SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.
 nal change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pair
 nal change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pair
zyme specific for phosphorylated Tyr (pTyr) residues, instead of pSer or pThr. This family has a distinctive active site signa
zyme specific for phosphorylated Tyr (pTyr) residues, instead of pSer or pThr. This family has a distinctive active site signa
mbers of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2
 R) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short con
 R) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short con
 R) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short con
ns such as enzymes, structural proteins, and proteins involved in the mineralization of the extracellular matrix. The drosop

 RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP ga
 RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP ga
nging the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.
nging the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.
nging the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.
aling, and mouse embryonic development. Mutations in C2cd3 mice resulted in lethality in some cases and exencephaly, a
g their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a w
moting apoptosis. The core of the pathway consists of a MST and LATS family kinase cascade that ultimately phosphorylate
hese proteins have been shown to play important roles in cell differentiation and organ development, and in regulating vira
 ngle transmembrane segment and a short cytoplasmic domain. The N-terminal domains of the alpha and beta subunits as
 by binding and preventing its own mRNA from being translated. S15 has a predominantly alpha-helical fold that is highly
. EF-hands tend to occur in pairs or higher copy numbers.
. EF-hands tend to occur in pairs or higher copy numbers.

 . EF-hands tend to occur in pairs or higher copy numbers.
 . EF-hands tend to occur in pairs or higher copy numbers.
 as a distinctive active site signature motif, HCSAGxGRxG. Characterized as either transmembrane, receptor-like or non-tra
 as a distinctive active site signature motif, HCSAGxGRxG. Characterized as either transmembrane, receptor-like or non-tra
s, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate pr
odules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and
odules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and
odules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and
extracellular matrix. The drosophila protein tolloid and its Xenopus homologue xolloid cleave and inactivate Sog and chordi

AP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-i
AP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-i
 omplex assemblies.
 omplex assemblies.
 omplex assemblies.
some cases and exencephaly, a twisted body axis, and pericardial edema in others. The presence of calcium-dependent lip
targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intrace
 e that ultimately phosphorylates and inactivates the YAP/Yorkie (Yki) transcription coactivator. The FERM domain proteins
elopment, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plu
 the alpha and beta subunits associate to form the integrin headpiece, which contains the ligand binding site, whereas the
alpha-helical fold that is highly structured except for the N-terminal alpha helix.




mbrane, receptor-like or non-transmembrane (soluble) PTPs. Receptor-like PTP domains tend to occur in two copies in the
mbrane, receptor-like or non-transmembrane (soluble) PTPs. Receptor-like PTP domains tend to occur in two copies in the
philin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge con
tely 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modu
tely 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modu
tely 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modu
e and inactivate Sog and chordin, respectively, which are inhibitors of Dpp (the Drosophila decapentaplegic gene product)

accharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and
accharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and




esence of calcium-dependent lipid-binding domains in C2cd3 suggests a potential role in vesicular transport. C2cd3 is also
 itol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that conta
  tor. The FERM domain proteins Merlin (Mer) and Expanded (Ex) are part of the upstream regulation controlling pathway m
 of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this mod
igand binding site, whereas the C-terminal segments traverse the plasma membrane and mediate interaction with the cyto




nd to occur in two copies in the cytoplasmic region of the transmembrane proteins, only one copy may be active.
nd to occur in two copies in the cytoplasmic region of the transmembrane proteins, only one copy may be active.
domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.
  system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other
  system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other
  system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other
 decapentaplegic gene product) and its homologue BMP4, involved in dorso-ventral patterning.

Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TU
Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TU




sicular transport. C2cd3 is also an interesting candidate for ciliopathy because of its orthology to certain cilia-related gene
ransduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which c
egulation controlling pathway mechanism. Kibra colocalizes and associates with Mer and Ex and is thought to transduce a
 e A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one o
mediate interaction with the cytoskeleton and with signalling proteins.The VWA domains present in the alpha subunits of in




e copy may be active.
e copy may be active.
ked against the disulfide bond.
n of the modules to each other is critical for function.
n of the modules to each other is critical for function.
n of the modules to each other is critical for function.


es human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta
es human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta




ogy to certain cilia-related genetic disease loci on chromosome. The C2 domain was first identified in PKC. C2 domains fold
ane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few excep
x and is thought to transduce an extracellular signal via the SWH network. The apical scaffold machinery that contains Hpo
 are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at t
esent in the alpha subunits of integrins seem to be a chordate specific radiation of the gene family being found only in vert




s family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[
s family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[




entified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Ty
However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and interse
old machinery that contains Hpo, Wts, and Ex recruits Yki to the apical membrane facilitating its inhibitory phosphorlyation
ple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and h
family being found only in vertebrates. They mediate protein-protein interactions.




erfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations i
erfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations i




al arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strand
 s of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have n
ng its inhibitory phosphorlyation by Wts. Since Kibra associates with Ex and is apically located it is hypothesized that KIBR
in which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which rep




ate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins
ate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins




r N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide v
a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
ted it is hypothesized that KIBRA is part of the scaffold, helps in the Hpo/Wts complex, and helps recruit Yki for inactivatio
n interaction module which represses transcription through recruiting corepressors. A key mechanism a




 n. For the majority of proteins in this family, these carboxylate residues are conserved.
 n. For the majority of proteins in this family, these carboxylate residues are conserved.




ting modules that bind a wide variety of substances including bind phospholipids, inositol polyp
e as ligands for calcium ions.
d helps recruit Yki for inactivation that promotes SWH pathway activity. Kibra contain
mechanism a
QM2-qcdsearch-74C25151AD4CE0FE-6D9B50D950C9C5AA

Query    gi accession no.
Q#1      gi|1065361
Q#44     gi|126304349
Q#45     gi|126304349
Q#69     gi|13562118
Q#71     gi|13562118
Q#72     gi|13562118
Q#74     gi|13562118
Q#143    gi|149731066
Q#145    gi|149757935
Q#159    gi|190360663
Q#169    gi|194217363
Q#175    gi|194227434
Q#176    gi|20071759
Q#176    gi|27806691
Q#184    gi|281353154
Q#263    gi|311268641
Q#263    gi|34533800
Q#271    gi|409226
Q#288    gi|4885637
Q#313    gi|73957808
Q#320    gi|74000055
Q#335
Q#335
Q#336
Q#336
Q#337
D4CE0FE-6D9B50D950C9C5AA

        Protein short name                                          Hit type
                                                                    specific
         Chain A, Human Adp-Ribosylation Factor 1 Complexed With Gdp, Full Length Non-Myristoylated
         similar to phospholipase C, beta 4                         specific
         similar to phospholipase C, beta 4                         specific
                                                                    specific
         low-density lipoprotein receptor-related protein 2 precursor
                                                                    specific
         low-density lipoprotein receptor-related protein 2 precursor
                                                                    specific
         low-density lipoprotein receptor-related protein 2 precursor
                                                                    specific
         low-density lipoprotein receptor-related protein 2 precursor
                                                                    specific
         similar to Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted)
                                                                    specific
         similar to pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
         FYVE and coiled-coil domain-containing protein 1           specific
         flotillin 2                                                specific
         similar to Synaptotagmin-2 (Synaptotagmin II) (SytII)      specific
         Unknown (protein for MGC:36892)                            specific
         lysosomal-trafficking regulator                            specific
         hypothetical protein PANDA_003347                          specific
         programmed cell death 6-interacting protein-like           specific
         unnamed protein product                                    specific
         brain beta spectrin                                        specific
         target of Myb protein 1 isoform 1                          specific
                                                                    specific
         similar to RAB, member of RAS oncogene family-like 5 (predicted)
                                                                    specific
         similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (Phosphoinositide phospholipase
Domain short name              Definition
Arf1_5_like                    Arf1-Arf5-like subfamily. This subfamily contains Arf1, Arf2,
PI-PLCc_beta                   Catalytic domain of metazoan phosphoinositide-specific phosp
C2_PLC_like                    C2 domain present in Phosphoinositide-specific phospholipase
LDLa                           Low Density Lipoprotein Receptor Class A domain, a cysteine-
LDLa                           Low Density Lipoprotein Receptor Class A domain, a cysteine-
LDLa                           Low Density Lipoprotein Receptor Class A domain, a cysteine-
LDLa                           Low Density Lipoprotein Receptor Class A domain, a cysteine-
PH_melted                      Melted pleckstrin homology (PH) domain; Melted pleckstrin ho
PH                             Pleckstrin homology (PH) domain; Pleckstrin homology (PH) d
FYVE                           FYVE domain; Zinc-binding domain; targets proteins to memb
Band_7_flotillin               Band_7_flotillin: a subgroup of the band 7 domain of flotillin
C2A_Synaptotagmin-1-5-6-9-10   C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9
EFh                            EF-hand, calcium binding motif; A diverse superfamily of calc
Beach                          BEACH (Beige and Chediak-Higashi) domains, implicated in m
C2_C2cd3                       C2 domain found in C2 calcium-dependent domain containing
V_Alix                         Middle V-domain of mammalian Alix and related domains are
C2_Kibra                       C2 domain found in Human protein Kibra; Kibra is thought to
PH_beta_spectrin               Beta-spectrin pleckstrin homology (PH) domain; Beta-spectrin
VHS_Tom1                       VHS domain family, Tom1 subfamily; The VHS domain is an e
Ras_like_GTPase                Ras-like GTPase superfamily. The Ras-like superfamily of sma
C2_PLC_like                    C2 domain present in Phosphoinositide-specific phospholipase
family contains Arf1, Arf2, Arf3, Arf4, Arf5, and related proteins. Arfs1-5 are soluble proteins that are crucial for assemblin
sphoinositide-specific phospholipase C-beta; This subfamily corresponds to the catalytic domain present in metazoan phos
 itide-specific phospholipases C (PLC); PLCs are involved in the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PIP2)
Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein
Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein
Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein
Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein
omain; Melted pleckstrin homology (PH) domain. The melted protein has a C-terminal PH domain. PH domains share little
  Pleckstrin homology (PH) domain. PH domains are only found in eukaryotes. They share little sequence conservation, but
n; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB,
   band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, H
  Synaptotagmins 1, 5, 6, 9, and 10; Synaptotagmin is a membrane-trafficking protein characterized by a N-terminal trans
 diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 act
 i) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This
pendent domain containing 3 (C2cd3) proteins; C2cd3 is a novel C2 domain-containing protein specific to vertebrates. C2
ix and related domains are dimerization and protein interaction modules; This family contains the middle V-shaped (V) do
n Kibra; Kibra is thought to be a regulator of the Salvador (Sav)/Warts (Wts)/Hippo (Hpo) (SWH) signaling network, which
 (PH) domain; Beta-spectrin pleckstrin homology (PH) domain. Beta spectrin binds actin and functions as a major compone
 ly; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a su
Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and function
 itide-specific phospholipases C (PLC); PLCs are involved in the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PIP2)
 ns that are crucial for assembling coat proteins during vesicle formation. Each contains an N-terminal myristoylated amph
main present in metazoan phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11)-beta isozymes. PI-PLC is a sign
 ositol-4,5-bisphosphate (PIP2) to d-myo-inositol-1,4,5-trisphosphate (1,4,5-IP3) and sn-1,2-diacylglycerol (DAG). 1,4,5-
metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of
metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of
metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of
metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of
  omain. PH domains share little sequence conservation, but all have a common fold, which is electrostatically polarized. PH
 tle sequence conservation, but all have a common fold, which is electrostatically polarized. PH domains also have diverse
 e, PI3P; present in Fab1, YOTB, Vac1, and EEA1;
   stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of this
 acterized by a N-terminal transmembrane region, a linker, and 2 C-terminal C2 domains. Synaptotagmin 1, a member of
 his alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand mot
ved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-li
  tein specific to vertebrates. C2cd3 functions in regulator of cilia formation, Hedgehog signaling, and mouse embryonic de
 ins the middle V-shaped (V) domain of mammalian Alix (apoptosis-linked gene-2 interacting protein X) and related domai
  SWH) signaling network, which limits tissue growth by inhibiting cell proliferation and promoting apoptosis. The core of th
 d functions as a major component of the cytoskeleton underlying cellular membranes. Beta spectrin consists of multiple sp
 otein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N
egree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ra
 ositol-4,5-bisphosphate (PIP2) to d-myo-inositol-1,4,5-trisphosphate (1,4,5-IP3) and sn-1,2-diacylglycerol (DAG). 1,4,5-
 N-terminal myristoylated amphipathic helix that is folded into the protein in the GDP-bound state. GDP/GTP exchange ex
-beta isozymes. PI-PLC is a signaling enzyme that hydrolyzes the membrane phospholipids phosphatidylinositol-4,5-bispho
2-diacylglycerol (DAG). 1,4,5-IP3 and DAG are second messengers in eukaryotic signal transduction cascades. PLC is com
 cessive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein
 cessive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein
 cessive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein
 cessive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein
 s electrostatically polarized. PH domains also have diverse functions. They are often involved in targeting proteins to the p
 PH domains also have diverse functions. They are often involved in targeting proteins to the plasma membrane, but few d

 ed. Individual proteins of this band 7 domain family may cluster to form membrane microdomains which may in turn recr
Synaptotagmin 1, a member of class 1 synaptotagmins, is located in the brain and endocranium and localized to the synap
 nal change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pair
 T), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome
 aling, and mouse embryonic development. Mutations in C2cd3 mice resulted in lethality in some cases and exencephaly, a
 g protein X) and related domains. It belongs to the V_Alix_like superfamily which includes the V-domains of Bro1 and Rim
moting apoptosis. The core of the pathway consists of a MST and LATS family kinase cascade that ultimately phosphorylate
  spectrin consists of multiple spectrin repeats followed by a PH domain, which binds to Inositol-1,4,5-Trisphosphate. PH d
eats and is present at the very N-termini of proteins. It is a right-handed superhelix of eight alpha helices. The VHS domain
 r families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP tra
 2-diacylglycerol (DAG). 1,4,5-IP3 and DAG are second messengers in eukaryotic signal transduction cascades. PLC is com
 d state. GDP/GTP exchange exposes the helix, which anchors to the membrane. Following GTP hydrolysis, the helix disso
 phosphatidylinositol-4,5-bisphosphate (PIP2) to generate two important second messengers in eukaryotic signal transduc
ansduction cascades. PLC is composed of a N-terminal PH domain followed by a series of EF hands, a catalytic TIM barrel a
 multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipo
 multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipo
 multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipo
 multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipo
 ed in targeting proteins to the plasma membrane, but few display strong specificity in lipid binding. Any specificity is usua
he plasma membrane, but few display strong specificity in lipid binding. Any specificity is usually determined by loop regio

domains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be
nium and localized to the synaptic vesicles and secretory granules. It functions as a Ca2+ sensor for fast exocytosis as do
 . EF-hands tend to occur in pairs or higher copy numbers.
ds to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurolo
some cases and exencephaly, a twisted body axis, and pericardial edema in others. The presence of calcium-dependent lip
 the V-domains of Bro1 and Rim20 (also known as PalA) from Saccharomyces cerevisiae, mammalian His-Domain type N23
 e that ultimately phosphorylates and inactivates the YAP/Yorkie (Yki) transcription coactivator. The FERM domain proteins
 sitol-1,4,5-Trisphosphate. PH domains share little sequence conservation, but all have a common fold, which is electrostat
t alpha helices. The VHS domain has been found in a number of proteins, some of which have been implicated in intracellu
 cludes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Mem
ansduction cascades. PLC is composed of a N-terminal PH domain followed by a series of EF hands, a catalytic TIM barrel a
g GTP hydrolysis, the helix dissociates from the membrane and folds back into the protein. A general feature of Arf1-5 sign
ers in eukaryotic signal transduction cascades, Inositol 1,4,5-trisphosphate (InsP3) and diacylglycerol (DAG). InsP3 trigge
F hands, a catalytic TIM barrel and a C-terminal C2 domain. C2 domains fold into an 8-standed beta-sandwich that can ado
 luding the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and
 luding the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and
 luding the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and
 luding the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and
  binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are no
 sually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH do

llin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signa
sensor for fast exocytosis as do synaptotagmins 5, 6, and 10. It is distinguished from the other synaptotagmins by having

r blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregu
esence of calcium-dependent lipid-binding domains in C2cd3 suggests a potential role in vesicular transport. C2cd3 is also
 ammalian His-Domain type N23 protein tyrosine phosphatase (HD-PTP, also known as PTPN23), and related domains. Alix
 tor. The FERM domain proteins Merlin (Mer) and Expanded (Ex) are part of the upstream regulation controlling pathway m
 mmon fold, which is electrostatically polarized. PH domains also have diverse functions. PH domains are often involved in
 ve been implicated in intracellular trafficking and sorting. The VHS domain of the Tom1 protein is essential for the negativ
  heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family re
F hands, a catalytic TIM barrel and a C-terminal C2 domain. C2 domains fold into an 8-standed beta-sandwich that can ado
 A general feature of Arf1-5 signaling may be the cooperation of two Arfs at the same site. Arfs1-5 are generally considere
 cylglycerol (DAG). InsP3 triggers inflow of calcium from intracellular stores, while DAG, together with calcium, activates pr
 ded beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation
  2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; th
  2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; th
  2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; th
  2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; th
nus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such
  not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase,

s have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and, interact with a variety o
ther synaptotagmins by having an N-glycosylated N-terminus. Synaptotagmins 5, 6, and 10, members of class 3 synaptot

utism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is importan
sicular transport. C2cd3 is also an interesting candidate for ciliopathy because of its orthology to certain cilia-related gene
N23), and related domains. Alix, also known as apoptosis-linked gene-2 interacting protein 1 (AIP1), is part of the ESCRT
egulation controlling pathway mechanism. Kibra colocalizes and associates with Mer and Ex and is thought to transduce a
H domains are often involved in targeting proteins to the plasma membrane via lipid binding. PH domains are found in cell
otein is essential for the negative regulation of Interleukin-1 and Tumor Necrosis Factor-induced signaling pathways.
ular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene ex
 ded beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation
  Arfs1-5 are generally considered to be interchangeable in function and location, but some specific functions have been as
 ether with calcium, activates protein kinase C, which goes on to phosphorylate other molecules, leading to altered cellular
 shed by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent mem
  component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is n
  component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is n
  component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is n
  component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is n
n cellular signaling proteins such as serine/threonine kinase, tyrosine kinsases, regulators of G-proteins, endocytotic GTPas
 uch as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytos

nt and, interact with a variety of proteins. Flotillins may play a role in the progression of prion disease, in the pathogenes
0, members of class 3 synaptotagmins, are located primarily in the brain and localized to the active zone and plasma mem

 EACH domain itself is important for the function of these proteins.
ogy to certain cilia-related genetic disease loci on chromosome. The C2 domain was first identified in PKC. C2 domains fold
  1 (AIP1), is part of the ESCRT (Endosomal Sorting Complexes Required for Transport) system, and participates in membr
x and is thought to transduce an extracellular signal via the SWH network. The apical scaffold machinery that contains Hpo
 g. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinsases, regulators of G-p
 uced signaling pathways.
etal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regu
 shed by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent mem
specific functions have been assigned. Arf1 localizes to the early/cis-Golgi, where it is activated by GBF1 and recruits the
cules, leading to altered cellular activity. Calcium is required for the catalysis. PLC-beta represents a class of mammalian P
mains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholip
 native disulfide isomer and is necessary in establishing and maintaining the modular structure
 native disulfide isomer and is necessary in establishing and maintaining the modular structure
 native disulfide isomer and is necessary in establishing and maintaining the modular structure
 native disulfide isomer and is necessary in establishing and maintaining the modular structure
 f G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
 ases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.

 rion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cance
he active zone and plasma membrane. They is distinguished from the other synaptotagmins by having disulfide bonds at i


entified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Ty
 em, and participates in membrane remodeling processes, including the budding of enveloped viruses, vesicle budding insi
old machinery that contains Hpo, Wts, and Ex recruits Yki to the apical membrane facilitating its inhibitory phosphorlyation
osine kinsases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in

ficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation facto
mains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholip
vated by GBF1 and recruits the coat protein COPI. It also localizes to the trans-Golgi network (TGN), where it is activated
resents a class of mammalian PI-PLC that has an N-terminal pleckstrin homology (PH) domain, an array of EF hands, a PLC
ances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either




nd in lipid associated enzymes.


zheimer's disease and, in cancer invasion and metastasis.
s by having disulfide bonds at its N-terminus. Synaptotagmin 6 also regulates the acrosome reaction, a unique Ca2+-reg


al arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strand
 ed viruses, vesicle budding inside late endosomal multivesicular bodies (MVBs), the abscission reactions of mammalian ce
ng its inhibitory phosphorlyation by Wts. Since Kibra associates with Ex and is apically located it is hypothesized that KIBR
etal associated molecules and in lipid associated enzymes.

ation. The GTP translation factor family regulate initiation, elongation, termination, and release in translation, and the Era-
ances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either
ork (TGN), where it is activated by BIG1/BIG2 and recruits the AP1, AP3, AP4, and GGA proteins. Humans, but not rodents
 ain, an array of EF hands, a PLC catalytic core domain, a C2 domain, and a unique C-terminal coiled-coil (CT) domain nec
st C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or




me reaction, a unique Ca2+-regulated exocytosis, in sperm. Synaptotagmin 9, a class 5 synaptotagmins, is located in the b


r N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide v
sion reactions of mammalian cell division, and in apoptosis. The Alix V-domain is a dimerization domain, and contains a bin
 ted it is hypothesized that KIBRA is part of the scaffold, helps in the Hpo/Wts complex, and helps recruit Yki for inactivatio


ease in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the
st C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or
teins. Humans, but not rodents and other lower eukaryotes, lack Arf2. Hum
 nal coiled-coil (CT) domain necessary for homodimerization. The PLC catalytic core domain is
ain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domai




 aptotagmins, is located in the brain and localized to the synaptic vesicles. It is thought to be a C


ting modules that bind a wide variety of substances including bind phospholipids, inositol polyp
ation domain, and contains a binding site, partially conserved in the V_Alix_like superfamily, for the retro
d helps recruit Yki for inactivation that promotes SWH pathway activity. Kibra contain


DNA replication. Members of the Ras superfamily are identified by the
ain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domai
y, for the retro
QM2-qcdsearch-74C25151AD4CE0FE-6D9B50D950C9C5AA

Query    gi accession no.   Protein short name
Q#7      gi|109110028        ubiquitin carboxyl-terminal hydrolase 20-like
Q#8      gi|109110028        ubiquitin carboxyl-terminal hydrolase 20-like
Q#9      gi|109110028        ubiquitin carboxyl-terminal hydrolase 20-like
Q#10     gi|109110028        ubiquitin carboxyl-terminal hydrolase 20-like
Q#32     gi|119900578        piwi like homolog 2-like, partial
Q#34     gi|119900578        piwi like homolog 2-like, partial
Q#35     gi|119900578        piwi like homolog 2-like, partial
Q#58     gi|126331695        similar to ubiquitin carboxyl-terminal esterase L1 (ubiquitin thioles
Q#110    gi|149409778        similar to DNA polymerase iota
Q#257    gi|311244608        probable E3 ubiquitin-protein ligase HERC1
Q#263    gi|311263940        ubiquitin carboxyl-terminal hydrolase 28-like
Q#263    gi|3133255          PGP9.5
Q#285    gi|47523318         ubiquitin carboxyl-terminal hydrolase isozyme L1
Q#290    gi|5002593          LSFR3A protein
Q#316    gi|73964993         similar to likely ortholog of mouse ubiquitin-conjugating enzyme E
Hit type      Domain short name
specific      Peptidase_C19R
superfamily   Peptidase_C19 superfamily
superfamily   DUSP superfamily
superfamily   zf-UBP superfamily
specific      PAZ_piwi_like
superfamily   PAZ superfamily
superfamily   Piwi-like superfamily
specific      Peptidase_C12_UCH_L1_L3
superfamily   PolY superfamily
specific      HECTc
specific      Peptidase_C19I
superfamily   Peptidase_C12 superfamily
specific      Peptidase_C12_UCH_L1_L3
superfamily   Peptidase_C19 superfamily
specific      UBCc
Definition
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases t
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecule
DUSP domain; The DUSP (domain present in ubiquitin-specific protease) domain is found at the N-terminus of
Zn-finger in ubiquitin-hydrolases and other protein; Zn-finger in ubiquitin-hydrolases and other protein.
PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the m
PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins th
Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of r
Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3; This ubiquit
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiqu
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases t
Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1; The
Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3; This ubiquit
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecule
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degra
 acellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They
ve ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the
at the N-terminus of Ubiquitin-specific proteases. The structure of this domain has been solved. Its tripod-like structure con
other protein.
be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in
amilies of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, t
 refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and
  and L3; This ubiquitin C-terminal hydrolase (UCH) family includes UCH-L1 and UCH-L3, the two members sharing around
 erases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike repl
  binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side c
acellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They
L3, L5 and BAP1; The ubiquitin C-terminal hydrolase (UCH; ubiquitinyl hydrolase; ubiquitin thiolesterase) family of deubiq
  and L3; This ubiquitin C-terminal hydrolase (UCH) family includes UCH-L1 and UCH-L3, the two members sharing around
ve ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the
ediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus
avage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. T
y hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitina
ved. Its tripod-like structure consists of a 3-fold alpha-helical bundle supporting a triple-stranded anti-parallel beta-sheet.

  iwi was shown to be involved in the silencing of retrotransposons in the male gametes. The Piwi proteins share their doma
 s, including RNA interference, the piwi and Dicer families. PAZ functions as a nucleic-acid binding domain, with a strong pr
  including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The central component of the RNA-induced silencing
 e two members sharing around 53% sequence identity as well as conserved catalytic residues. Both enzymes hydrolyze ca
 ety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and l
 iquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
avage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. Th
   thiolesterase) family of deubiquitinating enzymes (DUBs) consists of four members to date: UCH-L1, UCH-L3, UCH-L5 (UC
 e two members sharing around 53% sequence identity as well as conserved catalytic residues. Both enzymes hydrolyze ca
y hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitina
ved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin protein ligase enzymes, E3. This pathway regu
minal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, wh
he purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from deg
 anded anti-parallel beta-sheet.

e Piwi proteins share their domain architecture with other members of the argonaute family. The PAZ domain has been nam
 inding domain, with a strong preference for single-stranded nucleic acids (RNA or DNA) or RNA duplexes with single-stran
nt of the RNA-induced silencing complex (RISC) and related complexes is Argonaute. The PIWI domain is the C-terminal po
ues. Both enzymes hydrolyze carboxyl terminal esters and amides of ubiquitin (Ub). UCH-L1, in dimeric form, has addition
 ivity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the
nd of growing ubiquitin chains.
minal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, wh
e: UCH-L1, UCH-L3, UCH-L5 (UCH37) and BRCA1-associated protein-1 (BAP1), all containing a conserved catalytic domain
ues. Both enzymes hydrolyze carboxyl terminal esters and amides of ubiquitin (Ub). UCH-L1, in dimeric form, has addition
he purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from deg
  zymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thiol-ester
of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin
ch could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsi


. The PAZ domain has been named after the proteins Piwi, Argonaut, and Zwille. PAZ is found in two families of proteins t
RNA duplexes with single-stranded 3' overhangs. It has been suggested that the PAZ domain provides a unique mode for t
IWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the 5' anchoring
1, in dimeric form, has additional enzymatic activity as a ubiquitin ligase. It is highly abundant in the brain, constituting u
insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodatio

of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin
 g a conserved catalytic domain with cysteine peptidase activity. UCH-L1 hydrolyzes carboxyl terminal esters and amides
1, in dimeric form, has additional enzymatic activity as a ubiquitin ligase. It is highly abundant in the brain, constituting u
 ch could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsi
other E2s which form thiol-ester linkages without the use of E3s as well as several UBC homologs (TSG101, Mms2, Croc-1
g of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and w
/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C1


und in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA inte
 in provides a unique mode for the recognition of the two 3'-terminal nucleotides in single-stranded nucleic acids and burie
 which provides the 5' anchoring of the guide RNA and the other, the catalytic site for slicing. This domain is also found in c
dant in the brain, constituting up to 2% of total protein, and is expressed exclusively in neurons and testes. Abnormal expr
 exible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta

g of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and w
xyl terminal esters and amides of ubiquitin (Ub). Dysfunction of this hydrolase activity can lead to an accumulation of alph
dant in the brain, constituting up to 2% of total protein, and is expressed exclusively in neurons and testes. Abnormal expr
/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C1
mologs (TSG101, Mms2, Croc-1 and similar proteins) which lack the active site cysteine essential for ubiquitination and app
r in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human g
th over 50 members, family C19 is one of the largest families of peptidases in the human genome.


ng pathways, including RNA interference, the Piwi and Dicer families. PAZ functions as a nucleic acid binding domain, with
 tranded nucleic acids and buries the 3' OH group, and that it might recognize characteristic 3' overhangs in siRNAs within
g. This domain is also found in closely related proteins, including the Piwi subfamily, where it is believed to perform a cruc
 rons and testes. Abnormal expression of UCH-L1 has been shown to correlate with several forms of cancer, including seve
of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukary

r in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human g
lead to an accumulation of alpha-synuclein, which is linked to Parkinson's disease (PD) and neurofibrillary tangles, linked t
 rons and testes. Abnormal expression of UCH-L1 has been shown to correlate with several forms of cancer, including seve
 th over 50 members, family C19 is one of the largest families of peptidases in the human genome.
ential for ubiquitination and appear to function in DNA repair pathways which were omitted from the scope of this CD.
es of peptidases in the human genome.




 cleic acid binding domain, with a strong preference for single-stranded nucleic acids (RNA or DNA) or RNA duplexes with s
c 3' overhangs in siRNAs within RISC (RNA-induced silencing) and other complexes. This parent model also contains struct
  it is believed to perform a crucial role in germline cells, via a similar mechanism.
 forms of cancer, including several primary lung tumors, lung tumor cell lines, and colorectal cancers. Mutations in the UCH
clusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y

es of peptidases in the human genome.
 neurofibrillary tangles, linked to Alzheimer's disease (AD). UCH-L1, in its dimeric form, has additional enzymatic activity
forms of cancer, including several primary lung tumors, lung tumor cell lines, and colorectal cancers. Mutations in the UCH

 from the scope of this CD.
or DNA) or RNA duplexes with single-stranded 3' overhangs. It has been suggested that the PAZ domain provides a unique
arent model also contains structures of an archaeal PAZ domain.

al cancers. Mutations in the UCH-L1 gene have been linked to susceptibility to and protection from Parkinson's disease (PD
LS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated


as additional enzymatic activity as a ubiquitin ligase. UCH-L3 hydrolyzes isopeptide bonds at the C-terminal glycine of eith
al cancers. Mutations in the UCH-L1 gene have been linked to susceptibility to and protection from Parkinson's disease (PD
e PAZ domain provides a unique mode for the recognition of the two 3'-terminal nucleotides in single-stranded nucleic acid


 n from Parkinson's disease (PD); dysfunction of the hydrolase activity can lead to an accumulation of alpha-synuclein, wh
s believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which pro


at the C-terminal glycine of either Ub or Nedd8, a ubiquitin-like protein. UCH-L3 can also interact with Lys48-linked Ub dim
 n from Parkinson's disease (PD); dysfunction of the hydrolase activity can lead to an accumulation of alpha-synuclein, wh
s in single-stranded nucleic acids and buries the 3' OH group, and that it might recognize characteristic 3' overhangs in siR


mulation of alpha-synuclein, which is linked to Parkinson's disease (PD), while accumulation of neurofibrillary tangles is
 lication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of


teract with Lys48-linked Ub dimers to protect it from degradation while inhibiting its hydrolase activity at the same ti
mulation of alpha-synuclein, which is linked to Parkinson's disease (PD), while accumulation of neurofibrillary tangles is
haracteristic 3' overhangs in siRN


 of neurofibrillary tangles is
ess the lesion. Because of


ase activity at the same ti
 of neurofibrillary tangles is

				
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