Webtable 2A. RSI InHospital - Cleveland Clinic

Broadly Applicable Risk Stratification Sessler, et al









Webtable 2A. RSIINHOSP Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Odds Ratio Change [95% CI]

D038 Septicemia All subcodes except 0380, 03810, 03811 and 03819 0.438 1.549 [1.495 1.604]^^

D0380 Streptococcal septicemia All subcodes 0.544 1.723 [1.628 1.824]^

D03810 Staphylococcal septicemia, unspecified None 0.883 2.418 [2.197 2.661]^

D03811 Methicillin susceptible Staphylococcus aureus septicemia None 1.066 2.905 [2.795 3.019]#

D03819 Other staphylococcal septicemia None 0.629 1.875 [1.759 1.999]^

D0388 Other specified septicemias All subcodes 1.091 2.978 [2.775 3.196]^^^

D0389 Unspecified septicemia All subcodes 1.16 3.189 [3.129 3.250]#

D157 Malignant neoplasm of pancreas All subcodes 0.871 2.390 [2.269 2.516]^^^

D1622 Malignant neoplasm of main bronchus All subcodes 0.872 2.391 [2.183 2.620]^

D1623 Malignant neoplasm of upper lobe, bronchus or lung All subcodes 0.405 1.500 [1.435 1.568]^

D1628 Malignant neoplasm of other parts of bronchus or lung All subcodes 1.036 2.817 [2.644 3.001]^^^

D1629 Malignant neoplasm of bronchus and lung, unspecified All subcodes 0.965 2.626 [2.543 2.712]#

D1970 Secondary malignant neoplasm of lung All subcodes 0.626 1.870 [1.794 1.948]^^

D1972 Secondary malignant neoplasm of pleura All subcodes 0.865 2.376 [2.271 2.485]#

D1976 Secondary malignant neoplasm of retroperitoneum and peritoneum All subcodes 0.764 2.147 [2.051 2.248]^^^

D1977 Malignant neoplasm of liver, secondary All subcodes 0.911 2.486 [2.412 2.562]#

D1978 Secondary malignant neoplasm of other digestive organs and spleen All subcodes 0.608 1.837 [1.689 1.998]***

D198 Secondary malignant neoplasm of other specified sites All subcodes except 1983 and 1985 0.44 1.552 [1.495 1.611]^^

D1983 Secondary malignant neoplasm of brain and spinal cord All subcodes 0.604 1.830 [1.740 1.924]^^

D1985 Secondary malignant neoplasm of bone and bone marrow All subcodes 0.774 2.168 [2.100 2.239]#

D199 Malignant neoplasm without specification of site All subcodes except 1991 1.486 4.421 [3.892 5.022]^^

D1991 Other malignant neoplasm without specification of site All subcodes 0.896 2.451 [2.331 2.577]^^^



D200 Lymphosarcoma and reticulosarcoma and other specified malignant tumors of lymphatic tissue All subcodes 0.905 2.473 [2.272 2.691]^

D2028 Other lymphomas All subcodes except 20280 and 20283 0.878 2.405 [2.214 2.612]^

D20280 Other malignant lymphomas, unspecified site, extranodal and solid organ sites None 0.629 1.875 [1.781 1.975]^^

D20283 Other malignant lymphomas, intra-abdominal lymph nodes None 0.849 2.337 [2.092 2.611]^

D20300 Multiple myeloma, without mention of having achieved remission None 0.655 1.926 [1.828 2.028]^^

D20410 Chronic lymphoid leukemia, without mention of having achieved remission None 0.525 1.690 [1.599 1.786]^

D20500 Acute myeloid leukemia, without mention of having achieved remission None 1.759 5.806 [5.429 6.210]#

D208 Leukemia of unspecified cell type All subcodes 1.26 3.525 [3.127 3.973]^

D2113 Benign neoplasm of colon All subcodes -0.882 0.414 [0.390 0.439]^^

D2387 Other lymphatic and hematopoietic tissues All subcodes 0.473 1.604 [1.524 1.687]^

D261 Nutritional marasmus All subcodes 0.96 2.612 [2.445 2.789]^^

D262 Other severe protein-calorie malnutrition All subcodes 0.978 2.659 [2.375 2.978]^

D2639 Unspecified protein-calorie malnutrition All subcodes 0.56 1.750 [1.718 1.782]#

D2720 Pure hypercholesterolemia All subcodes -0.578 0.561 [0.547 0.575]#

D2724 Other and unspecified hyperlipidemia All subcodes -0.569 0.566 [0.555 0.577]#

D27542 Hypercalcemia None 0.554 1.741 [1.634 1.855]^

D2760 Hyperosmolality and/or hypernatremia All subcodes 0.5 1.649 [1.599 1.700]^^^

D2761 Hyposmolality and/or hyponatremia All subcodes 0.207 1.230 [1.209 1.252]^^

D2762 Acidosis All subcodes 0.648 1.912 [1.866 1.958]#

D2765 Volume depletion All subcodes 0.464 1.590 [1.571 1.610]#

D2767 Hyperpotassemia All subcodes 0.346 1.414 [1.386 1.443]^^^

D2768 Hypopotassemia All subcodes -0.172 0.842 [0.825 0.861]^

D2780 Overweight and obesity All subcodes -0.498 0.608 [0.586 0.631]^^

D2809 Iron deficiency anemia, unspecified All subcodes -0.377 0.686 [0.660 0.713]^

D2866 Defibrination syndrome All subcodes 1.527 4.606 [4.211 5.038]^^^

D2869 Other and unspecified coagulation defects All subcodes 0.559 1.749 [1.678 1.824]^^

D2875 Thrombocytopenia, unspecified All subcodes 0.331 1.393 [1.358 1.428]^^

D2900 Senile dementia, uncomplicated All subcodes 0.513 1.670 [1.596 1.747]^^

D2948 Other persistent mental disorders due to conditions classified elsewhere All subcodes 0.369 1.447 [1.416 1.479]^^^

D3051 Tobacco use disorder All subcodes -0.367 0.693 [0.673 0.712]^^

D348 Cerebral cysts All subcodes except 3481 and 3483 1.142 3.133 [2.860 3.432]^^

D3481 Anoxic brain damage All subcodes 1.919 6.817 [6.425 7.232]#

D3483 Encephalopathy, not elsewhere classified All subcodes 0.653 1.921 [1.830 2.016]^^

D4019 Unspecified essential hypertension All subcodes -0.261 0.770 [0.762 0.778]#

Hypertensive chronic kidney disease, unspecified, with chronic kidney disease stage V or end

D40391 stage renal disease None 0.135 1.144 [1.126 1.161]^

D41001 Acute myocardial infarction of anterolateral wall, initial episode of care None 1.47 4.350 [3.960 4.778]^^^

D41011 Acute myocardial infarction of other anterior wall, initial episode of care None 1.355 3.876 [3.690 4.072]#

D41021 Acute myocardial infarction of inferolateral wall, initial episode of care None 1.377 3.963 [3.543 4.433]^^

D41041 Acute myocardial infarction of other inferior wall, initial episode of care None 1.172 3.228 [3.073 3.392]#

D41071 Subendocardial infarction, initial episode of care None 0.564 1.757 [1.720 1.796]#

D41081 Acute myocardial infarction of other specified sites, initial episode of care None 1.227 3.411 [3.117 3.733]^^

D41091 Acute myocardial infarction of unspecified site, initial episode of care None 1.56 4.761 [4.603 4.925]#

D4139 Other and unspecified angina pectoris All subcodes -0.209 0.811 [0.784 0.839]***

D41511 Iatrogenic pulmonary embolism and infarction None * 1.426 4.161 [3.758 4.606]^^

D41519 Other pulmonary embolism and infarction None 0.868 2.381 [2.293 2.472]#

D4241 Aortic valve disorders All subcodes 0.205 1.228 [1.200 1.257]^

D427 Cardiac dysrhythmias All subcodes except 42731 and 42741 0.647 1.909 [1.884 1.935]#

D42731 Atrial fibrillation None 0.321 1.378 [1.364 1.392]#

D42741 Ventricular fibrillation None 1.974 7.197 [6.802 7.616]#

D428 Heart Failure All subcodes 0.519 1.681 [1.665 1.698]#

D430 Subarachnoid hemorrhage All subcodes 2.334 10.318 [9.462 11.251]#

D431 Intracerebral hemorrhage All subcodes 2.639 13.999 [13.361 14.668]#

D432 Other and unspecified intracranial hemorrhage All subcodes except 4321 2.226 9.262 [8.095 10.598]^^^

D4321 Subdural hemorrhage All subcodes 1.211 3.358 [3.144 3.586]^^^

D4340 Cerebral thrombosis All subcodes 1.419 4.132 [3.622 4.713]^

D43411 Cerebral embolism with cerebral infarction None 1.059 2.883 [2.719 3.058]^^^

D43491 Cerebral artery occlusion, unspecified with cerebral infarction None 1.189 3.283 [3.193 3.376]#

D4359 Unspecified transient cerebral ischemia All subcodes -0.555 0.574 [0.539 0.612]^

D436 Acute, but ill-defined, cerebrovascular disease All subcodes 1.072 2.922 [2.827 3.021]#

D43820 Late effects of cerebrovascular disease, hemiplegia affecting unspecified side None 0.262 1.299 [1.251 1.348]***

D44021 Atherosclerosis of native arteries of the extremities with intermittent claudication None -0.589 0.555 [0.505 0.609]***

D44024 Atherosclerosis of native arteries of the extremities with gangrene None 0.656 1.927 [1.848 2.010]^^^

D441 Aortic aneurysm and dissection All subcodes except 4410 and 4413 0.283 1.327 [1.281 1.374]^

D4410 Dissection of aorta All subcodes 1.996 7.357 [6.692 8.087]#

D4413 Abdominal aneurysm, ruptured All subcodes 2.982 19.733 [17.615 22.105]#

D44422 Arterial embolism and thrombosis of lower extremity None 0.844 2.325 [2.205 2.451]^^^

D4550 Internal hemorrhoids without mention of complication All subcodes -0.926 0.396 [0.359 0.437]^

D4582 Iatrogenic hypotension All subcodes * 0.476 1.610 [1.520 1.707]^

D4589 Hypotension, unspecified All subcodes 0.795 2.215 [2.160 2.271]#

D4824 Pneumonia due to Staphylococcus All subcodes 0.471 1.601 [1.539 1.664]^^

D485 Bronchopneumonia, organism unspecified All subcodes 1.122 3.071 [2.840 3.321]^^

D486 Pneumonia, organism unspecified All subcodes 0.705 2.024 [1.998 2.050]#

D493 Asthma All subcodes -0.331 0.718 [0.699 0.737]^^

D496 Chronic airway obstruction, not elsewhere classified All subcodes 0.18 1.197 [1.183 1.211]^^^

D5070 Pneumonitis due to inhalation of food or vomitus All subcodes 1.149 3.154 [3.093 3.218]#









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al









Webtable 2A. RSIINHOSP Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Odds Ratio Change [95% CI]

D5119 Unspecified pleural effusion All subcodes 0.411 1.509 [1.480 1.538]#

D5128 Other spontaneous pneumothorax All subcodes 0.62 1.859 [1.750 1.975]^

D515 Postinflammatory pulmonary fibrosis All subcodes 0.519 1.680 [1.625 1.737]^^^

D5163 Idiopathic fibrosing alveolitis All subcodes 0.97 2.639 [2.389 2.916]^

D5180 Pulmonary collapse All subcodes -0.212 0.809 [0.789 0.829]^

D5185 Pulmonary insufficiency following trauma and surgery All subcodes 1.121 3.067 [2.975 3.163]#

D5188 Other diseases of lung All subcodes 1.095 2.988 [2.947 3.030]#

D5533 Diaphragmatic hernia without mention of obstruction or gangrene All subcodes -0.358 0.699 [0.675 0.723]^

D5570 Acute vascular insufficiency of intestine All subcodes 1.554 4.731 [4.495 4.979]#

D5579 Unspecified vascular insufficiency of intestine All subcodes 0.72 2.054 [1.926 2.191]^^

D5609 Unspecified intestinal obstruction All subcodes 0.487 1.627 [1.570 1.686]^^

D567 Peritonitis and retroperitoneal infections All subcodes 0.816 2.261 [2.168 2.358]#

D570 Acute and subacute necrosis of liver All subcodes 1.342 3.825 [3.515 4.161]^^^

D5722 Hepatic encephalopathy All subcodes 1.254 3.506 [3.287 3.739]#

D5728 Other sequelae of chronic liver disease All subcodes 1.596 4.931 [4.375 5.558]^^

D5780 Hematemesis All subcodes 0.764 2.146 [2.040 2.258]^^

D5789 Hemorrhage of gastrointestinal tract, unspecified All subcodes 0.575 1.778 [1.743 1.814]#

D5845 Acute kidney failure with lesion of tubular necrosis All subcodes 0.809 2.246 [2.162 2.333]#

D5849 Acute renal failure, unspecified All subcodes 0.771 2.162 [2.130 2.195]#

D585 Chronic kidney disease All subcodes 0.302 1.352 [1.325 1.380]^^

D586 Renal failure, unspecified All subcodes 1.099 3.001 [2.848 3.162]#

D5939 Unspecified disorder of kidney and ureter All subcodes 0.205 1.227 [1.202 1.253]^

D7070 Chronic ulcer of skin All subcodes 0.609 1.839 [1.804 1.875]#

D71595 Osteoarthrosis, unspecified whether generalized or localized, pelvic region and thigh None -1.044 0.352 [0.317 0.392]^

D7169 Arthropathy, unspecified All subcodes -0.358 0.699 [0.667 0.732]^

D78001 Coma None 2.174 8.794 [8.066 9.587]#

D7812 Abnormality of gait All subcodes -0.87 0.419 [0.386 0.455]^

D783 Symptoms concerning nutrition, metabolism, and development All subcodes 0.429 1.536 [1.483 1.591]^^

D7840 Headache All subcodes -0.777 0.460 [0.418 0.507]^

D7854 Gangrene All subcodes 0.661 1.937 [1.857 2.021]^^^

D7855 Shock without mention of trauma All subcodes 1.299 3.666 [3.563 3.773]#

D7860 Enlargement of lymph nodes All subcodes 0.252 1.287 [1.261 1.313]^^

D78820 Retention of urine, unspecified None -0.27 0.763 [0.737 0.790]^

D789 Other symptoms involving abdomen and pelvis All subcodes 0.293 1.341 [1.313 1.369]^^

D799 Other ill-defined and unknown causes of morbidity and mortality All subcodes 0.672 1.958 [1.910 2.007]#

D801 Fracture of base of skull All subcodes 1.618 5.044 [4.439 5.731]^^

D8050 Cervical closed fracture of vertebral column without mention of spinal cord injury All subcodes 1.064 2.897 [2.592 3.237]^

D851 Cerebral laceration and contusion All subcodes 1.359 3.894 [3.480 4.358]^^

D852 Subarachnoid, subdural, and extradural hemorrhage, following injury All subcodes 1.577 4.838 [4.580 5.112]#

D853 Other and unspecified intracranial hemorrhage following injury All subcodes 1.711 5.536 [4.887 6.271]^^

D99702 Iatrogenic cerebrovascular infarction or hemorrhage None * 1.506 4.510 [4.168 4.880]#

D99811 Hemorrhage complicating a procedure None * 0.569 1.767 [1.695 1.841]^^

DV46 Encounter for dialysis and dialysis catheter care All subcodes 0.395 1.485 [1.420 1.553]^

DV5789 Care involving other specified rehabilitation procedure None -0.846 0.429 [0.409 0.450]^^^

DV58 Encounter for other and unspecified procedures and aftercare All subcodes -0.323 0.724 [0.706 0.743]^^

DV66 Convalescence and palliative care All subcodes 2.614 13.656 [12.550 14.860]#

P0051 Implantation of cardiac resynchronization defibrillator, total system [CRT-D] None -1.666 0.189 [0.162 0.220]^^

P0066 Percutaneous transluminal coronary angioplasty [PTCA] or coronary atherectomy None -0.792 0.453 [0.422 0.487]^^

P0309 Other exploration and decompression of spinal canal None -1.085 0.338 [0.311 0.369]^^

P0331 Spinal tap None 0.365 1.440 [1.380 1.502]^

P3404 Insertion of intercostal catheter for drainage None 0.515 1.674 [1.613 1.737]^^

Single vessel percutaneous transluminal coronary angioplasty or coronary atherectomy without

P3601 mention of thrombolytic agent None -0.528 0.590 [0.569 0.613]^^

P370 Pericardiocentesis All subcodes 1.141 3.131 [2.772 3.538]^

P3726 Catheter based invasive electrophysiologic testing None -1.224 0.294 [0.270 0.320]^^

P3761 Implant of pulsation balloon None 1.674 5.333 [5.069 5.610]#

P3778 Insertion of temporary transvenous pacemaker system None 0.572 1.771 [1.668 1.881]^

P3794 Implantation or replacement of automatic cardioverter/defibrillator, total system [AICD] None -1.826 0.161 [0.144 0.180]^^^

P3812 Endarterectomy, other vessels of head and neck None -0.981 0.375 [0.349 0.402]^^

P3893 Venous catheterization, not elsewhere classified None 0.651 1.918 [1.894 1.942]#

P3895 Venous catheterization for renal dialysis None 0.401 1.493 [1.449 1.539]^^

P3898 Other puncture of artery None 0.618 1.855 [1.768 1.947]^^

P4516 Esophagogastroduodenoscopy [EGD] with closed biopsy None -0.362 0.696 [0.681 0.712]^^^

P4523 Colonoscopy None -0.538 0.584 [0.566 0.603]^^^

P5123 Laparoscopic cholecystectomy None -0.779 0.459 [0.436 0.484]^^

P5411 Exploratory laparotomy None 1.19 3.287 [3.053 3.540]^^^

P5491 Percutaneous abdominal drainage None 0.479 1.615 [1.551 1.680]^^

P5794 Insertion of indwelling urinary catheter None 0.454 1.574 [1.517 1.633]^^

P6029 Other transurethral prostatectomy None -1.204 0.300 [0.276 0.327]^^

P8154 Total knee replacement None -2.033 0.131 [0.121 0.142]#

P8192 Injection of therapeutic substance into joint or ligament None -1.033 0.356 [0.317 0.400]^

P8411 Amputation of toe None -0.622 0.537 [0.494 0.583]***

P8853 Angiocardiography of left heart structures None -0.624 0.536 [0.523 0.549]#

P8872 Diagnostic ultrasound of heart None -0.305 0.737 [0.722 0.753]^^

P8891 Magnetic resonance imaging of brain and brain stem None -0.486 0.615 [0.585 0.646]^

P8964 Pulmonary artery wedge monitoring None 0.606 1.834 [1.751 1.920]^^

P8965 Measurement of systemic arterial blood gases None 0.646 1.907 [1.816 2.002]^^

P9205 Cardiovascular and hematopoietic scan and radioisotope function study None -1.024 0.359 [0.323 0.400]^

P9390 Non-invasive mechanical ventilation None 0.932 2.540 [2.462 2.621]#

P9394 Respiratory medication administered by nebulizer None 0.529 1.697 [1.635 1.762]^^

P9604 Insertion of endotracheal tube None 1.244 3.468 [3.403 3.535]#

P9605 Other intubation of respiratory tract None 0.928 2.530 [2.291 2.794]^

P9607 Insertion of other (naso-)gastric tube None 0.573 1.773 [1.698 1.852]^^

P9671 Continuous invasive mechanical ventilation for less than 96 consecutive hours None 0.698 2.010 [1.968 2.052]#

P9905 Transfusion of platelets None 0.701 2.015 [1.934 2.099]^^^

P9907 Transfusion of other serum None 0.526 1.692 [1.646 1.739]#

P9915 Parenteral infusion of concentrated nutritional substances None 0.648 1.912 [1.857 1.969]#

P9960 Cardiopulmonary resuscitation, not otherwise specified None 4.057 57.821 [54.308 61.562]#

constant Constant -2.198



P_ Symbol P Value

# -300

< 10

^^^

< 10-200

^^ -100

< 10

^

< 10-50

*** -25

< 10

**

< 10-10









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al









Webtable 2A. RSIINHOSP Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Odds Ratio Change [95% CI]

*

< 0.005









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al









Webtable 2B. RSI1Yr Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

D008 Intestinal infections due to other organisms All subcodes except 00845 -0.277 0.001 0.758 [0.734 0.782]^

D00845 Intestinal infection due to Clostridium difficile None 0.223 0.011 1.250 [1.240 1.259]#

D0380 Streptococcal septicemia All subcodes 0.171 0.002 1.186 [1.167 1.206]^

D03810 Staphylococcal septicemia, unspecified None 0.266 0.001 1.305 [1.270 1.340]^

D03811 Methicillin susceptible Staphylococcus aureus septicemia None 0.308 0.005 1.361 [1.346 1.377]#

D03819 Other staphylococcal septicemia None 0.212 0.002 1.236 [1.215 1.258]^^

D0388 Other specified septicemias All subcodes 0.258 0.001 1.294 [1.268 1.321]^^

D0389 Unspecified septicemia All subcodes 0.222 0.019 1.249 [1.241 1.256]#

Streptococcus infection in conditions classified elsewhere and of unspecified site,

D04104 streptococcus, group D [Enterococcus] None 0.184 0.005 1.202 [1.187 1.217]^^

Proteus (mirabilis) (morganii) infection in conditions classified elsewhere and of

D0416 unspecified site All subcodes 0.173 0.003 1.189 [1.169 1.209]^

D0417 Pseudomonas infection in conditions classified elsewhere and of unspecified site All subcodes 0.196 0.004 1.217 [1.201 1.234]^^

D07999 Unspecified viral infection None -0.434 0.001 0.648 [0.619 0.679]^

D1120 Candidiasis of mouth All subcodes 0.160 0.006 1.174 [1.162 1.186]^^^

D1122 Candidiasis of other urogenital sites All subcodes 0.347 0.002 1.415 [1.391 1.439]#

D11284 Candidal esophagitis None 0.270 0.002 1.310 [1.287 1.334]^^

D141 Malignant neoplasm of tongue All subcodes 0.542 0.000 1.719 [1.656 1.785]^^

D142 Malignant neoplasm of major salivary glands All subcodes 0.605 0.000 1.832 [1.717 1.955]^

D145 Malignant neoplasm of other and unspecified parts of mouth All subcodes 0.616 0.000 1.852 [1.754 1.954]^^

D148 Malignant neoplasm of hypopharynx All subcodes 0.513 0.000 1.671 [1.579 1.768]^

D150 Malignant neoplasm of esophagus All subcodes except 1509 0.927 0.001 2.527 [2.473 2.582]#

D1509 Malignant neoplasm of esophagus, unspecified site All subcodes 0.854 0.001 2.350 [2.298 2.404]#

D151 Malignant neoplasm of stomach All subcodes except 1510 and 1519 0.841 0.001 2.319 [2.269 2.369]#

D1510 Malignant neoplasm of cardia All subcodes 0.848 0.001 2.335 [2.275 2.397]#

D1519 Malignant neoplasm of stomach, unspecified site All subcodes 0.821 0.001 2.272 [2.217 2.329]#

D152 Malignant neoplasm of small intestine, including duodenum All subcodes 0.405 0.001 1.499 [1.449 1.552]^^

D1533 Malignant neoplasm of sigmoid colon All subcodes 0.211 0.003 1.235 [1.205 1.265]^

D1534 Malignant neoplasm of cecum All subcodes 0.341 0.003 1.407 [1.373 1.441]^^

D1536 Malignant neoplasm of ascending colon All subcodes 0.305 0.003 1.357 [1.322 1.392]^^

D1539 Malignant neoplasm of colon, unspecified site All subcodes 0.456 0.004 1.578 [1.556 1.601]#

D1540 Malignant neoplasm of rectosigmoid junction All subcodes 0.397 0.002 1.488 [1.451 1.526]^^^

D1541 Malignant neoplasm of rectum All subcodes 0.453 0.003 1.573 [1.541 1.605]#

D155 Malignant neoplasm of liver and intrahepatic bile ducts All subcodes 1.173 0.002 3.231 [3.178 3.285]#

D156 Malignant neoplasm of gallbladder and extrahepatic bile ducts All subcodes 1.002 0.001 2.724 [2.667 2.783]#

D157 Malignant neoplasm of pancreas All subcodes except 1570 and 1579 1.065 0.001 2.902 [2.843 2.961]#

D1570 Malignant neoplasm of head of pancreas All subcodes 1.027 0.001 2.794 [2.743 2.847]#

D1579 Malignant neoplasm of pancreas, part unspecified All subcodes 1.155 0.001 3.174 [3.124 3.224]#

D158 Malignant neoplasm of retroperitoneum and peritoneum All subcodes 0.591 0.001 1.805 [1.740 1.873]^^^

D161 Malignant neoplasm of larynx All subcodes 0.407 0.001 1.502 [1.459 1.546]^^

D162 Malignant neoplasm of trachea, bronchus, and lung All subcodes except 1622, 1623, 1625, 1628 and 1629 0.793 0.001 2.211 [2.149 2.276]#

D1622 Malignant neoplasm of main bronchus All subcodes 0.999 0.001 2.715 [2.665 2.767]#

D1623 Malignant neoplasm of upper lobe, bronchus or lung All subcodes 0.894 0.006 2.444 [2.419 2.469]#

D1625 Malignant neoplasm of lower lobe, bronchus or lung All subcodes 0.918 0.003 2.504 [2.471 2.537]#

D1628 Malignant neoplasm of other parts of bronchus or lung All subcodes 1.018 0.002 2.769 [2.730 2.808]#

D1629 Malignant neoplasm of bronchus and lung, unspecified All subcodes 1.016 0.009 2.762 [2.742 2.782]#

D163 Malignant neoplasm of pleura All subcodes 1.259 0.000 3.521 [3.388 3.658]#

D164 Malignant neoplasm of thymus, heart, and mediastinum All subcodes 0.706 0.000 2.025 [1.913 2.144]^^

D170 Malignant neoplasm of bone and articular cartilage All subcodes 0.682 0.000 1.977 [1.883 2.075]^^

D171 Malignant neoplasm of connective and other soft tissue All subcodes 0.731 0.001 2.078 [2.014 2.143]#

D172 Malignant melanoma of skin All subcodes 0.612 0.001 1.845 [1.782 1.911]^^^

D1749 Malignant neoplasm of breast (female), unspecified All subcodes 0.222 0.005 1.249 [1.229 1.269]^^

D179 Malignant neoplasm of uterus, part unspecified All subcodes 0.821 0.000 2.273 [2.176 2.374]^^^

D180 Malignant neoplasm of cervix uteri All subcodes except 1820 0.735 0.001 2.085 [2.013 2.160]#

D1820 Malignant neoplasm of corpus uteri, except isthmus All subcodes 0.650 0.003 1.916 [1.867 1.965]#

D183 Malignant neoplasm of ovary and other uterine adnexa All subcodes 0.586 0.003 1.796 [1.767 1.826]#

D184 Malignant neoplasm of other and unspecified female genital organs All subcodes 0.880 0.000 2.411 [2.310 2.515]#

D185 Malignant neoplasm of prostate All subcodes 0.450 0.015 1.568 [1.554 1.582]#

D188 Malignant neoplasm of bladder All subcodes except 1888 and 1889 0.361 0.002 1.435 [1.404 1.467]^^^

D1888 Malignant neoplasm of other specified sites of bladder All subcodes 0.533 0.002 1.704 [1.671 1.738]#

D1889 Malignant neoplasm of bladder, part unspecified All subcodes 0.594 0.003 1.812 [1.784 1.842]#

D189 Malignant neoplasm of kidney and other and unspecified urinary organs All subcodes except 1890 0.548 0.001 1.730 [1.668 1.794]^^

D1890 Malignant neoplasm of kidney, except pelvis All subcodes 0.521 0.003 1.684 [1.653 1.716]#

D191 Malignant neoplasm of brain All subcodes 1.671 0.001 5.315 [5.217 5.414]#

D195 Malignant neoplasm of other and ill-defined sites All subcodes 0.826 0.000 2.284 [2.212 2.358]#

D196 Secondary and unspecified malignant neoplasm of lymph nodes All subcodes except 1960, 1961, 1962, 193 and 1966 0.345 0.001 1.412 [1.377 1.448]^^



D1960 Secondary and unspecified malignant neoplasm of lymph nodes of head, face, and neck All subcodes 0.378 0.001 1.460 [1.427 1.495]^^^

D1961 Secondary and unspecified malignant neoplasm of intrathoracic lymph nodes All subcodes 0.175 0.002 1.191 [1.171 1.211]^

D1962 Secondary and unspecified malignant neoplasm of intra-abdominal lymph nodes All subcodes 0.252 0.005 1.286 [1.269 1.303]#



D1963 Secondary and unspecified malignant neoplasm of lymph nodes of axilla and upper limb All subcodes 0.361 0.002 1.435 [1.396 1.476]^^

D1966 Secondary and unspecified malignant neoplasm of intrapelvic lymph nodes All subcodes 0.385 0.001 1.469 [1.423 1.517]^^

D1970 Secondary malignant neoplasm of lung All subcodes 0.560 0.006 1.751 [1.735 1.767]#

D1972 Secondary malignant neoplasm of pleura All subcodes 0.705 0.004 2.023 [2.002 2.044]#

D1974 Secondary malignant neoplasm of small intestine including duodenum All subcodes 0.323 0.001 1.381 [1.350 1.413]^^

D1975 Secondary malignant neoplasm of large intestine and rectum All subcodes 0.303 0.001 1.354 [1.324 1.384]^^

D1976 Secondary malignant neoplasm of retroperitoneum and peritoneum All subcodes 0.689 0.005 1.992 [1.969 2.015]#

D1977 Malignant neoplasm of liver, secondary All subcodes 0.798 0.011 2.222 [2.206 2.238]#

D1978 Secondary malignant neoplasm of other digestive organs and spleen All subcodes 0.321 0.001 1.378 [1.354 1.403]^^^

D198 Secondary malignant neoplasm of other specified sites All subcodes except 1981, 1983, 1985, 19882 and 19889 0.356 0.002 1.427 [1.408 1.446]#

D1981 Secondary malignant neoplasm of other urinary organs All subcodes 0.436 0.001 1.546 [1.511 1.582]^^^

D1983 Secondary malignant neoplasm of brain and spinal cord All subcodes 0.814 0.004 2.258 [2.235 2.281]#

D1985 Secondary malignant neoplasm of bone and bone marrow All subcodes 0.730 0.010 2.076 [2.061 2.091]#

D19882 Secondary malignant neoplasm of genital organs None 0.314 0.001 1.369 [1.333 1.407]^^

D19889 Secondary malignant neoplasm of other specified sites None 0.418 0.004 1.519 [1.502 1.535]#

D199 Malignant neoplasm without specification of site All subcodes except 1991 0.920 0.000 2.510 [2.438 2.583]#

D1991 Other malignant neoplasm without specification of site All subcodes 0.890 0.004 2.435 [2.409 2.461]#

Lymphosarcoma and reticulosarcoma and other specified malignant tumors of lymphatic

D200 tissue All subcodes except 2000 0.613 0.000 1.846 [1.777 1.918]^^^

D2000 Reticulosarcoma All subcodes 0.926 0.001 2.525 [2.467 2.584]#

D201 Hodgkins disease All subcodes 0.640 0.000 1.897 [1.826 1.970]^^^

D2028 Other lymphomas All subcodes except 20280 and 20283 0.837 0.002 2.309 [2.265 2.353]#

D20280 Other malignant lymphomas, unspecified site, extranodal and solid organ sites None 0.686 0.004 1.986 [1.962 2.011]#

D20283 Other malignant lymphomas, intra-abdominal lymph nodes None 0.733 0.001 2.081 [2.026 2.137]#

D203 Multiple myeloma and immunoproliferative neoplasms All subcodes except 20300 0.536 0.000 1.710 [1.627 1.798]^

D20300 Multiple myeloma, without mention of having achieved remission None 0.785 0.004 2.192 [2.167 2.218]#

D204 Lymphoid leukemia All subcodes except 20410 0.737 0.001 2.089 [2.021 2.158]#

D20410 Chronic lymphoid leukemia, without mention of having achieved remission None 0.532 0.004 1.702 [1.679 1.725]#









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al









Webtable 2B. RSI1Yr Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

D205 Myeloid leukemia All subcodes except 20500 and 20510 0.590 0.000 1.804 [1.722 1.891]^^

D20500 Acute myeloid leukemia, without mention of having achieved remission None 1.448 0.002 4.256 [4.186 4.328]#

D20510 Chronic myeloid leukemia, without mention of having achieved remission None 0.875 0.001 2.398 [2.337 2.462]#

D208 Leukemia of unspecified cell type All subcodes 0.786 0.001 2.194 [2.131 2.259]#

D220 Benign neoplasm of ovary All subcodes -0.641 0.002 0.527 [0.492 0.565]^

D2330 Carcinoma in situ of breast All subcodes -0.683 0.001 0.505 [0.461 0.552]***

D2387 Other lymphatic and hematopoietic tissues All subcodes 0.727 0.005 2.069 [2.047 2.092]#

D239 Neoplasms of unspecified nature All subcodes 0.266 0.003 1.305 [1.280 1.330]^^

D2449 Unspecified acquired hypothyroidism All subcodes 0.039 0.091 1.040 [1.035 1.044]^

Diabetes mellitus without mention of complication, type II or unspecified type, not

D25000 stated as uncontrolled None 0.066 0.166 1.068 [1.064 1.071]#

Diabetes mellitus without mention of complication, type I [juvenile type], not stated as

D25001 uncontrolled None 0.150 0.013 1.162 [1.152 1.173]^^^



D25041 Diabetes with renal manifestations, type I [juvenile type], not stated as uncontrolled None 0.142 0.002 1.153 [1.132 1.175]***

Diabetes with other specified manifestations, type II or unspecified type, not stated as

D25080 uncontrolled None 0.135 0.008 1.145 [1.132 1.159]^^

D2536 Other disorders of neurohypophysis All subcodes 0.151 0.002 1.163 [1.143 1.184]^

D260 Kwashiorkor All subcodes 0.267 0.001 1.306 [1.270 1.343]^

D261 Nutritional marasmus All subcodes 0.518 0.002 1.679 [1.651 1.707]#

D262 Other severe protein-calorie malnutrition All subcodes 0.493 0.001 1.638 [1.591 1.688]^^^

D263 Other and unspecified protein-calorie malnutrition All subcodes except 2639 0.302 0.002 1.353 [1.332 1.375]#

D2639 Unspecified protein-calorie malnutrition All subcodes 0.360 0.027 1.433 [1.426 1.440]#

D2720 Pure hypercholesterolemia All subcodes -0.373 0.073 0.689 [0.685 0.694]#

D2724 Other and unspecified hyperlipidemia All subcodes -0.338 0.111 0.713 [0.710 0.717]#

D2729 Unspecified disorder of lipoid metabolism All subcodes -0.449 0.002 0.638 [0.611 0.666]^

D273 Disorders of plasma protein metabolism All subcodes 0.242 0.004 1.274 [1.256 1.292]^^^

D27542 Hypercalcemia None 0.372 0.003 1.451 [1.429 1.473]#

D2760 Hyperosmolality and/or hypernatremia All subcodes 0.372 0.008 1.451 [1.439 1.463]#

D2761 Hyposmolality and/or hyponatremia All subcodes 0.153 0.042 1.165 [1.159 1.170]#

D2762 Acidosis All subcodes 0.092 0.013 1.096 [1.088 1.105]^^

D2765 Volume depletion All subcodes 0.270 0.086 1.310 [1.306 1.315]#

D2767 Hyperpotassemia All subcodes 0.192 0.024 1.212 [1.206 1.219]#

D2769 Electrolyte and fluid disorders not elsewhere classified All subcodes 0.155 0.005 1.168 [1.153 1.183]^^

D2780 Overweight and obesity All subcodes -0.317 0.029 0.728 [0.720 0.735]#

D2800 Iron deficiency anemia secondary to blood loss (chronic) All subcodes 0.110 0.034 1.116 [1.109 1.122]^^^

D2819 Unspecified deficiency anemia All subcodes 0.206 0.003 1.229 [1.208 1.250]^^

D283 Acquired hemolytic anemias All subcodes 0.200 0.001 1.221 [1.191 1.251]^

D2848 Other specified aplastic anemias All subcodes 0.269 0.009 1.309 [1.298 1.320]#

D285 Other and unspecified anemias All subcodes 0.163 0.171 1.177 [1.174 1.181]#

D2866 Defibrination syndrome All subcodes 0.323 0.001 1.381 [1.342 1.420]^^

D2867 Acquired coagulation factor deficiency All subcodes 0.174 0.002 1.190 [1.168 1.212]^

D2869 Other and unspecified coagulation defects All subcodes 0.196 0.005 1.216 [1.201 1.230]^^^

D2873 Primary thrombocytopenia All subcodes 0.196 0.002 1.217 [1.188 1.246]^

D2874 Secondary thrombocytopenia All subcodes 0.219 0.004 1.245 [1.227 1.263]^^

D2875 Thrombocytopenia, unspecified All subcodes 0.235 0.017 1.265 [1.256 1.273]#

D2888 Other specified disease of white blood cells All subcodes 0.200 0.006 1.222 [1.207 1.237]^^^

D2898 Other specified diseases of blood and blood-forming organs All subcodes 0.265 0.002 1.303 [1.276 1.332]^^

D290 Dementias All subcodes except 2900, 2904 and 29040 0.484 0.002 1.622 [1.588 1.656]#

D2900 Senile dementia, uncomplicated All subcodes 0.583 0.007 1.791 [1.772 1.809]#

D2904 Vascular dementia All subcodes 0.452 0.001 1.571 [1.523 1.620]^^

D29040 Vascular dementia, uncomplicated None 0.470 0.004 1.600 [1.579 1.621]#

D2930 Delirium due to conditions classified elsewhere All subcodes 0.188 0.005 1.207 [1.190 1.223]^^

D2941 Dementia in conditions classified elsewhere All subcodes 0.238 0.019 1.269 [1.257 1.283]#

D2948 Other persistent mental disorders due to conditions classified elsewhere All subcodes 0.549 0.031 1.731 [1.722 1.740]#

D2989 Unspecified psychosis All subcodes 0.209 0.006 1.233 [1.217 1.248]^^^

D30301 Acute alcoholic intoxication in alcoholism, continuous None -0.367 0.000 0.693 [0.647 0.742]***

D30500 Alcohol abuse, unspecified None -0.186 0.004 0.830 [0.815 0.846]^

D3109 Unspecified nonpsychotic mental disorder following organic brain damage All subcodes 0.456 0.002 1.578 [1.547 1.609]#

D311 Depressive disorder, not elsewhere classified All subcodes 0.124 0.035 1.132 [1.125 1.139]#

D331 Other cerebral degenerations All subcodes except 3310 0.160 0.004 1.174 [1.157 1.192]^

D3310 Alzheimer's disease All subcodes 0.415 0.025 1.514 [1.500 1.528]#

D3320 Paralysis agitans All subcodes 0.232 0.016 1.261 [1.251 1.271]#

D335 Anterior horn cell disease All subcodes 0.647 0.001 1.910 [1.849 1.973]#

D336 Other diseases of spinal cord All subcodes 0.410 0.001 1.507 [1.468 1.546]^^^

D340 Multiple sclerosis All subcodes -0.170 0.002 0.844 [0.820 0.869]***

D34290 Hemiplegia, unspecified, affecting unspecified side None 0.284 0.006 1.329 [1.312 1.346]#

D344 Other paralytic syndromes All subcodes 0.156 0.004 1.169 [1.150 1.188]^

Migraine, unspecified, without mention of intractable migraine without mention of

D34690 status migrainosus None -0.587 0.002 0.556 [0.527 0.586]^^

D3481 Anoxic brain damage All subcodes 0.446 0.002 1.562 [1.532 1.593]#

D3483 Encephalopathy, not elsewhere classified All subcodes 0.234 0.004 1.264 [1.247 1.281]^^^

D359 Muscular dystrophies and other myopathies All subcodes 0.302 0.001 1.353 [1.307 1.400]^

D3690 Profound impairment, both eyes All subcodes 0.321 0.001 1.378 [1.345 1.412]^^

D3861 Other and unspecified peripheral vertigo All subcodes -0.564 0.001 0.569 [0.536 0.604]^

D3899 Unspecified hearing loss All subcodes 0.172 0.005 1.188 [1.168 1.209]^

D396 Diseases of mitral and aortic valves All subcodes except 3962 and 3968 0.120 0.008 1.128 [1.114 1.142]^

D3962 Mitral valve insufficiency and aortic valve stenosis All subcodes 0.336 0.004 1.400 [1.379 1.422]#

D3968 Multiple involvement of mitral and aortic valves All subcodes 0.250 0.001 1.284 [1.251 1.319]^

D39891 Rheumatic heart failure (congestive) None 0.376 0.005 1.456 [1.435 1.478]#

D4019 Unspecified essential hypertension All subcodes -0.115 0.454 0.891 [0.889 0.894]#

Hypertensive chronic kidney disease, unspecified, with chronic kidney disease stage V

D40391 or end stage renal disease None 0.245 0.061 1.277 [1.271 1.283]#

Hypertensive heart and chronic kidney disease, unspecified, without heart failure and

D40492 with chronic kidney disease stage V or end stage renal disease None 0.262 0.002 1.299 [1.271 1.328]^^

Hypertensive heart and chronic kidney disease, unspecified, with heart failure and

D40493 chronic kidney disease stage V or end stage renal disease None 0.247 0.004 1.280 [1.263 1.297]^^^

All subcodes except 41001, 41011, 41041, 41071, 41072,

D410 Acute myocardial infarction 41081 and 41091 0.196 0.007 1.216 [1.197 1.236]^^

D41001 Acute myocardial infarction of anterolateral wall, initial episode of care None 0.394 0.001 1.483 [1.433 1.536]^^

D41011 Acute myocardial infarction of other anterior wall, initial episode of care None 0.347 0.005 1.415 [1.390 1.440]#

D41041 Acute myocardial infarction of other inferior wall, initial episode of care None 0.183 0.006 1.201 [1.177 1.226]^

D41071 Subendocardial infarction, initial episode of care None 0.299 0.032 1.349 [1.341 1.358]#

D41072 Subendocardial infarction, subsequent episode of care None 0.302 0.002 1.353 [1.319 1.387]^^

D41081 Acute myocardial infarction of other specified sites, initial episode of care None 0.349 0.001 1.418 [1.376 1.462]^^

D41091 Acute myocardial infarction of unspecified site, initial episode of care None 0.340 0.008 1.405 [1.388 1.422]#

D414 Other forms of chronic ischemic heart disease All subcodes 0.110 0.314 1.116 [1.113 1.119]#

D4160 Primary pulmonary hypertension All subcodes 0.188 0.002 1.207 [1.183 1.232]^

D4168 Other chronic pulmonary heart diseases All subcodes 0.143 0.011 1.154 [1.143 1.165]^^

D4169 Chronic pulmonary heart disease, unspecified All subcodes 0.332 0.003 1.394 [1.371 1.418]#









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al









Webtable 2B. RSI1Yr Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

D4210 Acute and subacute bacterial endocarditis All subcodes 0.264 0.001 1.302 [1.273 1.332]^^

D4241 Aortic valve disorders All subcodes 0.255 0.030 1.291 [1.283 1.300]#

D4254 Other primary cardiomyopathies All subcodes 0.169 0.033 1.184 [1.178 1.191]#

D4260 Atrioventricular block, complete All subcodes 0.137 0.008 1.147 [1.129 1.166]^

D427 Cardiac dysrhythmias All subcodes except 42731 and 42741 0.054 0.096 1.056 [1.051 1.060]^^

D42731 Atrial fibrillation None 0.272 0.179 1.312 [1.309 1.316]#

D42741 Ventricular fibrillation None 0.212 0.002 1.236 [1.207 1.266]^

D428 Heart Failure All subcodes 0.409 0.206 1.505 [1.500 1.509]#

D431 Intracerebral hemorrhage All subcodes 0.402 0.003 1.495 [1.471 1.520]#

D4321 Subdural hemorrhage All subcodes 0.213 0.002 1.237 [1.210 1.264]^

D43311 Occlusion and stenosis of carotid artery with cerebral infarction None 0.294 0.001 1.342 [1.303 1.382]^

D43411 Cerebral embolism with cerebral infarction None 0.334 0.003 1.397 [1.371 1.422]^^^

D43491 Cerebral artery occlusion, unspecified with cerebral infarction None 0.368 0.013 1.445 [1.433 1.458]#

D4359 Unspecified transient cerebral ischemia All subcodes -0.119 0.009 0.888 [0.876 0.901]^

D436 Acute, but ill-defined, cerebrovascular disease All subcodes 0.269 0.011 1.309 [1.296 1.322]#

D438 Late effects of cerebrovascular disease All subcodes except 43811 and 43820 0.208 0.015 1.231 [1.221 1.242]#

D43811 Late effects of cerebrovascular disease, aphasia None 0.241 0.004 1.273 [1.254 1.293]^^^

D43820 Late effects of cerebrovascular disease, hemiplegia affecting unspecified side None 0.200 0.012 1.222 [1.211 1.234]#

D4401 Atherosclerosis of renal artery All subcodes -0.142 0.007 0.868 [0.851 0.885]***

D44020 Atherosclerosis of native arteries of the extremities, unspecified None 0.176 0.006 1.192 [1.174 1.210]^^

D44023 Atherosclerosis of native arteries of the extremities with ulceration None 0.294 0.004 1.342 [1.319 1.365]^^^

D44024 Atherosclerosis of native arteries of the extremities with gangrene None 0.498 0.007 1.645 [1.628 1.663]#

D44029 Other atherosclerosis of native arteries of the extremities None 0.313 0.001 1.367 [1.312 1.424]***

D4413 Abdominal aneurysm, ruptured All subcodes 0.372 0.000 1.451 [1.368 1.540]***

D4414 Abdominal aneurysm without mention of rupture All subcodes 0.235 0.013 1.265 [1.251 1.280]#

D443 Other peripheral vascular disease All subcodes 0.172 0.043 1.188 [1.181 1.195]#

D44422 Arterial embolism and thrombosis of lower extremity None 0.218 0.004 1.243 [1.222 1.264]^^

D453 Other venous embolism and thrombosis All subcodes 0.227 0.017 1.255 [1.247 1.264]#

D4589 Hypotension, unspecified All subcodes 0.136 0.015 1.146 [1.137 1.155]^^^

D481 Pneumococcal pneumonia [Streptococcus pneumoniae pneumonia] All subcodes -0.150 0.002 0.861 [0.841 0.881]***

D4820 Pneumonia due to Klebsiella pneumoniae All subcodes 0.236 0.001 1.266 [1.235 1.298]^

D4821 Pneumonia due to Pseudomonas All subcodes 0.302 0.002 1.353 [1.333 1.374]#

D4824 Pneumonia due to Staphylococcus All subcodes 0.227 0.005 1.255 [1.242 1.269]#

D485 Bronchopneumonia, organism unspecified All subcodes 0.225 0.001 1.252 [1.223 1.282]^

D486 Pneumonia, organism unspecified All subcodes 0.229 0.067 1.257 [1.253 1.261]#

D4912 Obstructive chronic bronchitis All subcodes 0.313 0.040 1.368 [1.361 1.375]#

D4928 Other emphysema All subcodes 0.209 0.013 1.232 [1.221 1.244]#

D493 Asthma All subcodes -0.088 0.035 0.916 [0.909 0.922]^^

D496 Chronic airway obstruction, not elsewhere classified All subcodes 0.252 0.130 1.287 [1.283 1.291]#

D5070 Pneumonitis due to inhalation of food or vomitus All subcodes 0.442 0.019 1.556 [1.547 1.565]#

D508 Respiratory conditions due to other and unspecified external agents All subcodes 0.278 0.000 1.321 [1.271 1.373]***

D5118 Other specified forms of effusion, except tuberculous All subcodes 0.181 0.003 1.199 [1.179 1.220]^

D5119 Unspecified pleural effusion All subcodes 0.254 0.029 1.289 [1.282 1.297]#

D5128 Other spontaneous pneumothorax All subcodes 0.213 0.003 1.237 [1.216 1.259]^^

D515 Postinflammatory pulmonary fibrosis All subcodes 0.367 0.010 1.443 [1.429 1.456]#

D5163 Idiopathic fibrosing alveolitis All subcodes 0.550 0.001 1.734 [1.687 1.782]#

D5185 Pulmonary insufficiency following trauma and surgery All subcodes 0.203 0.008 1.225 [1.210 1.239]^^^

D5188 Other diseases of lung All subcodes 0.244 0.047 1.276 [1.270 1.282]#

D5190 Tracheostomy complications All subcodes * 0.259 0.001 1.296 [1.257 1.336]^

D5301 Esophagitis All subcodes 0.054 0.014 1.056 [1.046 1.066]***

D5308 Other specified disorders of esophagus All subcodes -0.083 0.087 0.920 [0.916 0.925]^^^

D536 Disorders of function of stomach All subcodes 0.158 0.010 1.171 [1.159 1.182]^^^

D5370 Acquired hypertrophic pyloric stenosis All subcodes 0.349 0.001 1.417 [1.386 1.449]^^^

D558 Other and unspecified noninfectious gastroenteritis and colitis All subcodes -0.153 0.008 0.858 [0.847 0.869]^^

D56039 Other impaction of intestine None 0.279 0.004 1.322 [1.305 1.339]#

D56081 Intestinal or peritoneal adhesions with obstruction (postoperative) (postinfection) None -0.397 0.005 0.672 [0.659 0.685]#

D56089 Other specified intestinal obstruction None 0.262 0.003 1.300 [1.280 1.320]^^^

D5609 Unspecified intestinal obstruction All subcodes 0.125 0.009 1.133 [1.121 1.146]^^

D56210 Diverticulosis of colon (without mention of hemorrhage) None -0.122 0.028 0.885 [0.878 0.893]^^

D56211 Diverticulitis of colon (without mention of hemorrhage) None -0.228 0.009 0.796 [0.784 0.808]^^

D56212 Diverticulosis of colon with hemorrhage None -0.189 0.010 0.828 [0.816 0.839]^^

D5640 Constipation All subcodes 0.088 0.021 1.092 [1.083 1.100]^^

D5641 Irritable bowel syndrome All subcodes -0.297 0.005 0.743 [0.725 0.762]^^

D5693 Hemorrhage of rectum and anus All subcodes 0.126 0.008 1.134 [1.120 1.148]^

D5712 Alcoholic cirrhosis of liver All subcodes 0.405 0.003 1.499 [1.476 1.522]#

D5715 Cirrhosis of liver without mention of alcohol All subcodes 0.452 0.006 1.572 [1.555 1.590]#

D5722 Hepatic encephalopathy All subcodes 0.608 0.002 1.837 [1.805 1.869]#

D5723 Portal hypertension All subcodes 0.172 0.002 1.188 [1.164 1.212]^

D5728 Other sequelae of chronic liver disease All subcodes 0.609 0.000 1.839 [1.780 1.900]^^^

D5762 Obstruction of bile duct All subcodes 0.369 0.002 1.446 [1.419 1.473]#

D5768 Other specified disorders of biliary tract All subcodes 0.254 0.002 1.289 [1.263 1.316]^^

D5780 Hematemesis All subcodes 0.163 0.005 1.177 [1.160 1.193]^^

D5789 Hemorrhage of gastrointestinal tract, unspecified All subcodes 0.135 0.041 1.145 [1.139 1.151]#

D5829 Chronic glomerulonephritis with unspecified pathological lesion in kidney All subcodes 0.308 0.001 1.361 [1.322 1.402]^

D5845 Acute kidney failure with lesion of tubular necrosis All subcodes 0.123 0.005 1.131 [1.117 1.146]^

D5849 Acute renal failure, unspecified All subcodes 0.177 0.041 1.194 [1.189 1.199]#

D585 Chronic kidney disease All subcodes 0.337 0.025 1.401 [1.393 1.409]#

D586 Renal failure, unspecified All subcodes 0.289 0.003 1.335 [1.315 1.355]#

D591 Hydronephrosis All subcodes 0.318 0.009 1.374 [1.359 1.388]#

D5920 Calculus of kidney All subcodes -0.308 0.004 0.735 [0.717 0.753]^^

D5921 Calculus of ureter All subcodes -0.607 0.004 0.545 [0.528 0.561]#

D593 Other disorders of kidney and ureter All subcodes except 5939 0.068 0.005 1.070 [1.053 1.087]**

D5939 Unspecified disorder of kidney and ureter All subcodes 0.262 0.042 1.299 [1.292 1.306]#

D5961 Intestinovesical fistula All subcodes 0.307 0.001 1.359 [1.303 1.417]***

D5990 Urinary tract infection, site not specified All subcodes 0.222 0.097 1.248 [1.244 1.252]#

D5996 Urinary obstruction All subcodes 0.156 0.002 1.169 [1.148 1.191]^

D5997 Hematuria All subcodes 0.160 0.020 1.174 [1.166 1.183]#

D6180 Prolapse of vaginal walls without mention of uterine prolapse All subcodes -0.887 0.004 0.412 [0.388 0.436]^^

D6256 Stress incontinence, female All subcodes -0.538 0.005 0.584 [0.557 0.613]^^

D7070 Chronic ulcer of skin All subcodes 0.610 0.026 1.840 [1.832 1.849]#

D7071 Ulcer of lower limbs, except pressure ulcer All subcodes 0.281 0.021 1.324 [1.315 1.333]#

D7078 Chronic ulcer of other specified sites All subcodes 0.421 0.001 1.524 [1.486 1.564]^^^

D7101 Systemic sclerosis All subcodes 0.350 0.001 1.419 [1.377 1.462]^^

D7140 Rheumatoid arthritis All subcodes 0.118 0.014 1.125 [1.113 1.137]^^

D715 Osteoarthrosis and allied disorders All subcodes except 71515, 71535, 71536 and 71595 -0.043 0.082 0.958 [0.953 0.964]^

D71515 Osteoarthrosis, localized, primary, pelvic region and thigh None -0.689 0.002 0.502 [0.466 0.540]^

Osteoarthrosis, localized, not specified whether primary or secondary, pelvic region and

D71535 thigh None -0.550 0.011 0.577 [0.560 0.595]^^^

D71536 Osteoarthrosis, localized, not specified whether primary or secondary, lower leg None -0.245 0.026 0.783 [0.767 0.800]^^









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al









Webtable 2B. RSI1Yr Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]



D71595 Osteoarthrosis, unspecified whether generalized or localized, pelvic region and thigh None -0.426 0.008 0.653 [0.634 0.673]^^

D71690 Arthropathy, unspecified, site unspecified None -0.139 0.014 0.870 [0.858 0.881]^

D72210 Displacement of lumbar intervertebral disc without myelopathy None -0.403 0.007 0.668 [0.646 0.692]^^

D72402 Spinal stenosis, lumbar region None -0.276 0.014 0.759 [0.743 0.774]^^

D7291 Myalgia and myositis, unspecified All subcodes -0.361 0.003 0.697 [0.675 0.719]^^

D7318 Other bone involvement in diseases classified elsewhere All subcodes -0.229 0.002 0.795 [0.773 0.817]^

D7331 Pathologic fracture All subcodes except 73313 and 73314 0.315 0.001 1.370 [1.342 1.399]^^

D73313 Pathologic fracture of vertebrae None 0.287 0.008 1.333 [1.317 1.348]#

D73314 Pathologic fracture of neck of femur None 0.205 0.001 1.228 [1.196 1.262]^

D78001 Coma None 0.689 0.001 1.991 [1.941 2.043]#

D78009 Other alteration of consciousness None 0.236 0.006 1.266 [1.252 1.280]#

D78039 Other convulsions None 0.095 0.027 1.100 [1.093 1.106]^^^

D7823 Edema All subcodes 0.218 0.005 1.243 [1.225 1.260]^^^

D7824 Jaundice, unspecified, not of newborn All subcodes 0.411 0.002 1.508 [1.478 1.538]#

D783 Symptoms concerning nutrition, metabolism, and development All subcodes 0.373 0.010 1.452 [1.440 1.463]#

D7840 Headache All subcodes -0.300 0.004 0.741 [0.723 0.758]^^

D7851 Palpitations All subcodes -0.507 0.002 0.602 [0.574 0.631]^

D7854 Gangrene All subcodes 0.423 0.007 1.526 [1.510 1.542]#

D7856 Enlargement of lymph nodes All subcodes 0.205 0.002 1.227 [1.202 1.252]^

D7859 Other symptoms involving cardiovascular system All subcodes -0.205 0.001 0.815 [0.772 0.860]**

D7860 Enlargement of lymph nodes All subcodes 0.121 0.031 1.129 [1.123 1.135]#

D78650 Chest pain, unspecified None -0.112 0.043 0.894 [0.887 0.901]^^

D78659 Other chest pain None -0.282 0.018 0.754 [0.744 0.764]#

D7866 Swelling, mass, or lump in chest All subcodes 0.399 0.004 1.490 [1.470 1.510]#

D7872 Dysphagia All subcodes 0.324 0.015 1.382 [1.372 1.392]#

D78820 Retention of urine, unspecified None 0.093 0.021 1.097 [1.088 1.106]^^

D7889 Other symptoms involving urinary system All subcodes 0.231 0.002 1.260 [1.236 1.284]^^

D789 Other symptoms involving abdomen and pelvis All subcodes except 78900 0.220 0.026 1.246 [1.238 1.255]#

D78900 Abdominal pain, unspecified site None 0.057 0.017 1.059 [1.049 1.068]***

D790 Nonspecific findings on examination of blood All subcodes 0.063 0.022 1.065 [1.058 1.072]^

D799 Other ill-defined and unknown causes of morbidity and mortality All subcodes 0.293 0.016 1.341 [1.332 1.351]#

D82009 Other closed transcervical fracture of neck of femur None 0.112 0.010 1.118 [1.105 1.131]^

D82021 Closed fracture of intertrochanteric section of neck of femur None 0.137 0.017 1.147 [1.137 1.157]^^^

D8208 Closed fracture of unspecified part of neck of femur All subcodes 0.083 0.016 1.087 [1.078 1.097]^

D853 Other and unspecified intracranial hemorrhage following injury All subcodes 0.356 0.000 1.428 [1.366 1.493]^

D933 Foreign body in pharynx and larynx All subcodes 0.299 0.001 1.348 [1.304 1.393]^

D995 Certain adverse effects not elsewhere classified All subcodes 0.086 0.009 1.090 [1.080 1.100]^

D99673 Other complications due to renal dialysis device, implant, and graft None * 0.151 0.005 1.163 [1.149 1.178]^^

D997 Complications affecting specified body systems, not elsewhere classified All subcodes except 99702 * -0.099 0.038 0.906 [0.899 0.912]^^

D99702 Iatrogenic cerebrovascular infarction or hemorrhage None * 0.481 0.001 1.617 [1.572 1.662]^^^

D99811 Hemorrhage complicating a procedure None * -0.171 0.008 0.843 [0.831 0.856]^^

D99859 Other postoperative infection None * -0.151 0.009 0.860 [0.849 0.870]^^

DE849 Place of Occurrence All subcodes except E8497 -0.086 0.016 0.918 [0.908 0.928]^

DE8497 Accidents occurring in residential institution None 0.222 0.007 1.248 [1.231 1.265]^^^

DE884 Other fall from one level to another All subcodes 0.273 0.001 1.314 [1.272 1.359]^

DE888 Other and unspecified fall All subcodes 0.185 0.005 1.203 [1.184 1.222]^^

DV090 Infection with microorganisms resistant to penicillins All subcodes 0.267 0.008 1.306 [1.293 1.319]#

DV100 Personal history of malignant neoplasm of gastrointestinal tract All subcodes except V1002 and V1005 0.406 0.004 1.501 [1.478 1.523]#



DV1002 Personal history of malignant neoplasm of other and unspecified oral cavity and pharynx None 0.326 0.001 1.385 [1.336 1.436]^

DV1005 Personal history of malignant neoplasm of large intestine None 0.170 0.014 1.185 [1.174 1.196]^^^

DV1011 Personal history of malignant neoplasm of bronchus and lung None 0.494 0.005 1.639 [1.618 1.660]#

DV1021 Personal history of malignant neoplasm of larynx None 0.296 0.001 1.344 [1.308 1.381]^^

DV103 Personal history of malignant neoplasm of breast All subcodes 0.068 0.020 1.070 [1.061 1.079]^

DV104 Personal history of malignant neoplasm of genital organs All subcodes 0.155 0.022 1.168 [1.159 1.177]#

DV105 Personal history of malignant neoplasm of urinary organs All subcodes 0.206 0.008 1.229 [1.214 1.244]^^^

DV108 Personal history of malignant neoplasm of other sites All subcodes 0.138 0.008 1.148 [1.133 1.164]^

DV1259 Personal history of other diseases of circulatory system None 0.126 0.033 1.134 [1.126 1.141]^^^

DV1272 Personal history of colonic polyps None -0.365 0.003 0.694 [0.674 0.715]^^

DV173 Family history of ischemic heart disease All subcodes -0.496 0.006 0.609 [0.589 0.630]^^

DV43 Organ or tissue replaced by other means All subcodes except V4365 -0.083 0.026 0.920 [0.911 0.928]^

DV4365 Knee joint replacement None -0.448 0.017 0.639 [0.629 0.649]#

DV44 Artificial opening status All subcodes 0.299 0.009 1.348 [1.336 1.361]#

DV4501 Cardiac pacemaker in situ None 0.179 0.027 1.196 [1.187 1.204]#

DV4502 Automatic implantable cardiac defibrillator in situ None 0.209 0.004 1.232 [1.210 1.253]^^

DV451 Postsurgical renal dialysis status All subcodes 0.092 0.012 1.096 [1.087 1.106]^^

DV454 Arthrodesis status All subcodes -0.486 0.002 0.615 [0.585 0.646]^

DV458 Other postprocedural status All subcodes -0.112 0.103 0.894 [0.890 0.899]#

DV46 Encounter for dialysis and dialysis catheter care All subcodes 0.280 0.004 1.323 [1.306 1.340]#

DV4975 Below knee amputation status None 0.199 0.003 1.220 [1.199 1.242]^^

DV4976 Above knee amputation status None 0.278 0.002 1.321 [1.295 1.347]^^

DV5789 Care involving other specified rehabilitation procedure None -0.170 0.021 0.844 [0.835 0.854]^^^

DV58 Encounter for other and unspecified procedures and aftercare All subcodes -0.050 0.037 0.951 [0.945 0.957]^

DV644 Closed surgical procedure converted to open procedure All subcodes -0.437 0.003 0.646 [0.622 0.671]^^

DV66 Convalescence and palliative care All subcodes 1.089 0.001 2.970 [2.903 3.039]#

P0045 Insertion of one vascular stent None -0.355 0.003 0.701 [0.676 0.728]^

P0051 Implantation of cardiac resynchronization defibrillator, total system [CRT-D] None -0.476 0.002 0.621 [0.601 0.640]^^

P0309 Other exploration and decompression of spinal canal None -0.904 0.011 0.405 [0.394 0.416]#



P0390 Insertion of catheter into spinal canal for infusion of therapeutic or palliative substances None -0.254 0.005 0.776 [0.758 0.794]^^

P062 Unilateral thyroid lobectomy All subcodes -1.351 0.001 0.259 [0.234 0.287]^^

P0689 Other parathyroidectomy None -1.284 0.001 0.277 [0.254 0.302]^^

P311 Temporary tracheostomy All subcodes 0.290 0.004 1.337 [1.322 1.353]#

P3129 Other permanent tracheostomy None 0.305 0.001 1.357 [1.325 1.389]^^

P3229 Other local excision or destruction of lesion or tissue of lung None -0.926 0.002 0.396 [0.384 0.408]#

P324 Lobectomy of lung All subcodes -1.245 0.003 0.288 [0.280 0.296]#

P3326 Closed [percutaneous] [needle] biopsy of lung None 0.134 0.003 1.143 [1.127 1.158]^

P3328 Open biopsy of lung None -0.280 0.001 0.756 [0.734 0.779]^

P3451 Decortication of lung None -0.282 0.001 0.754 [0.729 0.781]^

P3491 Thoracentesis None 0.190 0.018 1.209 [1.200 1.218]#

P3521 Replacement of aortic valve with tissue graft None -0.443 0.003 0.642 [0.620 0.664]^^

P3522 Other replacement of aortic valve None -0.456 0.002 0.634 [0.610 0.660]^^

Single vessel percutaneous transluminal coronary angioplasty or coronary atherectomy

P3601 without mention of thrombolytic agent None -0.206 0.041 0.814 [0.801 0.827]^^

P3606 Insertion of non-drug-eluting coronary artery stent(s) None -0.300 0.031 0.741 [0.729 0.754]^^^

P3607 Insertion of drug-eluting coronary artery stent(s) None -0.540 0.021 0.583 [0.572 0.594]#

P3615 Single internal mammary-coronary artery bypass None -0.644 0.020 0.525 [0.516 0.535]#

P3722 Left heart cardiac catheterization None -0.195 0.096 0.823 [0.814 0.832]^^^









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al









Webtable 2B. RSI1Yr Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

P3726 Catheter based invasive electrophysiologic testing None -0.208 0.009 0.812 [0.796 0.828]^

P3734 Excision or destruction of other lesion or tissue of heart, other approach None -0.360 0.003 0.698 [0.676 0.720]^^

P3761 Implant of pulsation balloon None 0.226 0.003 1.254 [1.224 1.285]^

Insertion, revision, replacement and removal of leads; insertion of temp pacemaker; or

P377 revision of cardiac device pocket All subcodes except 3772 and 3776 -0.130 0.010 0.878 [0.866 0.890]^

P3772 Initial insertion of transvenous leads [electrodes] into atrium and ventricle None -0.454 0.019 0.635 [0.628 0.643]#

P3776 Replacement of transvenous atrial and/or ventricular lead(s) [electrode] None -0.402 0.001 0.669 [0.639 0.701]^



P3794 Implantation or replacement of automatic cardioverter/defibrillator, total system [AICD] None -0.311 0.006 0.733 [0.718 0.749]^^

P3812 Endarterectomy, other vessels of head and neck None -0.810 0.016 0.445 [0.437 0.453]#

P3844 Resection of vessel with replacement, aorta, abdominal None -1.036 0.003 0.355 [0.341 0.369]#

P3891 Arterial catheterization None -0.098 0.006 0.907 [0.895 0.919]***

P3893 Venous catheterization, not elsewhere classified None 0.140 0.067 1.150 [1.146 1.154]#

P3898 Other puncture of artery None 0.135 0.004 1.144 [1.128 1.160]^

P3925 Aorta-iliac-femoral bypass None -0.747 0.001 0.474 [0.453 0.496]^^^

P3927 Arteriovenostomy for renal dialysis None -0.198 0.003 0.820 [0.805 0.834]^^

P3929 Other (peripheral) vascular shunt or bypass None -0.383 0.008 0.682 [0.672 0.693]#

P3961 Extracorporeal circulation auxiliary to open heart surgery None -0.662 0.023 0.516 [0.507 0.525]#

P3971 Endovascular implantation of graft in abdominal aorta None -0.939 0.002 0.391 [0.375 0.408]#

P3995 Hemodialysis None 0.331 0.041 1.392 [1.384 1.400]#

P4023 Excision of axillary lymph node None -0.648 0.001 0.523 [0.492 0.555]^

P4029 Simple excision of other lymphatic structure None -0.397 0.002 0.672 [0.651 0.694]^^

P403 Regional lymph node excision All subcodes -0.528 0.005 0.590 [0.576 0.604]#

P4041 Radical neck dissection, unilateral None -0.383 0.001 0.682 [0.655 0.711]^

P405 Radical excision of other lymph nodes All subcodes -0.361 0.001 0.697 [0.658 0.738]***

P4311 Percutaneous [endoscopic] gastrostomy [PEG] None 0.246 0.017 1.279 [1.271 1.287]#

P4319 Other gastrostomy None 0.286 0.002 1.331 [1.308 1.354]^^^

P442 Pyloroplasty All subcodes -0.288 0.001 0.750 [0.721 0.779]***

P444 Control of hemorrhage and suture of ulcer of stomach or duodenum All subcodes -0.184 0.007 0.832 [0.821 0.844]^^

P4466 Other procedures for creation of esophagogastric sphincteric competence None -1.317 0.001 0.268 [0.245 0.294]^^

P4516 Esophagogastroduodenoscopy [EGD] with closed biopsy None -0.090 0.052 0.914 [0.909 0.919]^^^

P4523 Colonoscopy None -0.178 0.031 0.837 [0.831 0.843]#

P4542 Endoscopic polypectomy of large intestine None -0.194 0.013 0.824 [0.815 0.833]^^^

P4573 Open and other right hemicolectomy None -0.518 0.008 0.596 [0.584 0.607]#

P4575 Open and other left hemicolectomy None -0.448 0.003 0.639 [0.622 0.657]^^^

P4576 Open and other sigmoidectomy None -0.559 0.006 0.572 [0.559 0.585]#

P4579 Other and unspecified partial excision of large intestine None -0.301 0.002 0.740 [0.716 0.765]^

P4610 Colostomy, not otherwise specified None 0.321 0.002 1.379 [1.346 1.414]^^

P4611 Temporary colostomy None 0.211 0.001 1.235 [1.189 1.283]***

P4613 Permanent colostomy None 0.356 0.001 1.427 [1.379 1.475]^

P462 Ileostomy All subcodes 0.417 0.001 1.518 [1.474 1.564]^^

P4652 Closure of stoma of large intestine None -0.839 0.002 0.432 [0.410 0.456]^^^

P4685 Dilation of intestine None 0.274 0.001 1.315 [1.275 1.356]^

P4701 Laparoscopic appendectomy None -1.487 0.001 0.226 [0.206 0.249]^^^

P4709 Other appendectomy None -0.870 0.002 0.419 [0.403 0.437]#

P485 Abdominoperineal resection of rectum All subcodes -0.761 0.001 0.467 [0.443 0.493]^^

P486 Other resection of rectum All subcodes except 4863 -0.476 0.001 0.621 [0.592 0.650]^

P4863 Other anterior resection of rectum None -0.986 0.002 0.373 [0.357 0.390]#

P5011 Closed (percutaneous) [needle] biopsy of liver None 0.345 0.003 1.412 [1.395 1.430]#

P5122 Cholecystectomy None -0.434 0.007 0.648 [0.637 0.660]#

P5123 Laparoscopic cholecystectomy None -0.768 0.015 0.464 [0.456 0.471]#

P5187 Endoscopic insertion of stent (tube) into bile duct None 0.164 0.003 1.178 [1.155 1.201]^

P5188 Endoscopic removal of stone(s) from biliary tract None -0.435 0.003 0.647 [0.629 0.666]^^

P5198 Other percutaneous procedures on biliary tract None 0.362 0.001 1.436 [1.399 1.474]^^

P521 Diagnostic procedures on pancreas All subcodes 0.216 0.001 1.241 [1.208 1.276]^

P5304 Other and open repair of indirect inguinal hernia with graft or prosthesis None -0.425 0.001 0.654 [0.619 0.690]^

P5349 Other open umbilical herniorrhaphy None -0.282 0.002 0.754 [0.729 0.781]^

P5361 Other open incisional hernia repair with graft or prosthesis None -1.109 0.003 0.330 [0.316 0.344]#



P5369 Other and open repair of other hernia of anterior abdominal wall with graft or prosthesis None -0.856 0.001 0.425 [0.398 0.454]^^

P5421 Laparoscopy None -0.371 0.002 0.690 [0.669 0.712]^^

P544 Excision or destruction of peritoneal tissue All subcodes -0.300 0.003 0.741 [0.725 0.758]^^

P5491 Percutaneous abdominal drainage None 0.525 0.007 1.690 [1.674 1.708]#

P5498 Peritoneal dialysis None 0.588 0.001 1.800 [1.762 1.838]#

P5551 Nephroureterectomy None -0.887 0.003 0.412 [0.398 0.426]#

P560 Transurethral removal of obstruction from ureter and renal pelvis All subcodes -0.348 0.002 0.706 [0.671 0.742]***

P5794 Insertion of indwelling urinary catheter None 0.148 0.008 1.160 [1.148 1.172]^^

P5979 Other repair of urinary stress incontinence None -1.143 0.003 0.319 [0.289 0.352]^^

P6029 Other transurethral prostatectomy None -0.687 0.013 0.503 [0.496 0.511]#

P605 Radical prostatectomy All subcodes -2.688 0.003 0.068 [0.061 0.075]#

P656 Bilateral salpingo-oophorectomy All subcodes except 6561 -1.328 0.001 0.265 [0.233 0.302]^

P6561 Other removal of both ovaries and tubes at same operative episode None -1.016 0.007 0.362 [0.352 0.372]#

P6859 Other and unspecified vaginal hysterectomy None -1.121 0.003 0.326 [0.296 0.360]^^

P7050 Repair of cystocele and rectocele None -1.590 0.004 0.204 [0.186 0.223]^^^

P7051 Repair of cystocele None -1.415 0.002 0.243 [0.214 0.276]^^

P7779 Excision of bone for graft, other bones None -0.633 0.004 0.531 [0.505 0.559]^^

P7849 Other repair or plastic operations on bone, other bones None -0.272 0.002 0.762 [0.741 0.784]^

P7932 Open reduction of fracture with internal fixation, radius and ulna None -0.614 0.001 0.541 [0.516 0.567]^^

P7936 Open reduction of fracture with internal fixation, tibia and fibula None -0.751 0.004 0.472 [0.458 0.486]#

P8051 Excision of intervertebral disc None -1.030 0.009 0.357 [0.344 0.370]#

P8108 Lumbar and lumbosacral fusion, posterior technique None -0.926 0.005 0.396 [0.376 0.417]^^^

P8151 Total hip replacement None -0.976 0.018 0.377 [0.367 0.388]#

P8153 Revision of hip replacement, not otherwise specified None -0.835 0.003 0.434 [0.418 0.449]#

P8154 Total knee replacement None -2.017 0.037 0.133 [0.129 0.136]#

P8155 Revision of knee replacement, not otherwise specified None -1.551 0.003 0.212 [0.199 0.225]#

P8166 Percutaneous vertebral augmentation None -0.286 0.001 0.751 [0.720 0.784]***

P8180 Total shoulder replacement None -1.778 0.001 0.169 [0.152 0.188]^^^

P8181 Partial shoulder replacement None -1.013 0.002 0.363 [0.342 0.385]^^^

P8183 Other repair of shoulder None -1.115 0.001 0.328 [0.291 0.368]^

P8191 Arthrocentesis None -0.130 0.005 0.878 [0.863 0.894]***

P8363 Rotator cuff repair None -1.619 0.003 0.198 [0.184 0.212]#

P8415 Other amputation below knee None -0.228 0.003 0.796 [0.782 0.811]^^

P8541 Unilateral simple mastectomy None -0.650 0.001 0.522 [0.491 0.554]^

P8543 Unilateral extended simple mastectomy None -0.960 0.004 0.383 [0.369 0.398]#

P8604 Other incision with drainage of skin and subcutaneous tissue None -0.134 0.006 0.875 [0.862 0.889]^

P8669 Other skin graft to other sites None -0.312 0.002 0.732 [0.713 0.752]^^

P8703 Computerized axial tomography of head None 0.093 0.020 1.098 [1.090 1.107]^^

P8774 Retrograde pyelogram None -0.149 0.006 0.862 [0.848 0.876]^

P8841 Arteriography of cerebral arteries None -0.248 0.010 0.780 [0.768 0.793]^^^









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al









Webtable 2B. RSI1Yr Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

P8845 Arteriography of renal arteries None -0.234 0.006 0.791 [0.773 0.809]^

P8853 Angiocardiography of left heart structures None -0.257 0.086 0.773 [0.764 0.782]#

P8856 Coronary arteriography using two catheters None -0.183 0.102 0.833 [0.824 0.842]^^^

P8871 Diagnostic ultrasound of head and neck None -0.218 0.005 0.804 [0.790 0.819]^^

P8872 Diagnostic ultrasound of heart None -0.157 0.044 0.855 [0.850 0.860]#

P8891 Magnetic resonance imaging of brain and brain stem None -0.130 0.009 0.878 [0.867 0.889]^

P8941 Cardiovascular stress test using treadmill None -0.774 0.001 0.461 [0.436 0.488]^^

P8944 Other cardiovascular stress test None -0.467 0.007 0.627 [0.614 0.640]#

P8959 Other nonoperative cardiac and vascular measurements None -0.422 0.002 0.656 [0.631 0.681]^^

P9224 Teleradiotherapy using photons None 0.298 0.001 1.347 [1.324 1.371]^^^

P9227 Implantation or insertion of radioactive elements None -0.529 0.002 0.589 [0.566 0.612]^^

P9229 Other radiotherapeutic procedure None 0.286 0.004 1.331 [1.316 1.347]#

P9383 Occupational therapy None -0.128 0.021 0.880 [0.871 0.889]^^

P9390 Non-invasive mechanical ventilation None 0.124 0.007 1.132 [1.121 1.144]^^

P9396 Other oxygen enrichment None 0.099 0.007 1.104 [1.091 1.116]^

P9427 Other electroshock therapy None -0.594 0.001 0.552 [0.526 0.579]^^

P9444 Other group therapy None -0.284 0.001 0.753 [0.722 0.786]***

P9462 Alcohol detoxification None -0.481 0.002 0.618 [0.596 0.641]^^

P966 Enteral infusion of concentrated nutritional substances All subcodes 0.093 0.010 1.098 [1.090 1.106]^^

P970 Nonoperative replacement of gastrointestinal appliance All subcodes 0.181 0.003 1.199 [1.182 1.216]^^

P9902 Transfusion of previously collected autologous blood None -0.719 0.005 0.487 [0.457 0.519]^^

P9903 Other transfusion of whole blood None 0.254 0.001 1.289 [1.244 1.337]***

P9904 Transfusion of packed cells None 0.185 0.129 1.203 [1.199 1.207]#

P9905 Transfusion of platelets None 0.228 0.005 1.256 [1.242 1.271]#

P9910 Injection or infusion of thrombolytic agent None -0.142 0.004 0.868 [0.852 0.885]***

P9919 Injection of anticoagulant None -0.137 0.005 0.872 [0.857 0.887]^

P9960 Cardiopulmonary resuscitation, not otherwise specified None 0.310 0.001 1.364 [1.332 1.396]^^

P9961 Atrial cardioversion None -0.384 0.004 0.681 [0.666 0.696]^^^

P9962 Other electric countershock of heart None -0.222 0.005 0.801 [0.787 0.815]^^



P_ Symbol P Value

#

< 10-300

^^^

< 10-200

^^

< 10-100

^

< 10-50

***

< 10-25

**

< 10-10

*

< 0.005









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al





Webtable 2C. RSILOS Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

D00845 Intestinal infection due to Clostridium difficile None 0.587 0.011 1.798 [1.790 1.807]#

D011 Pulmonary tuberculosis All subcodes 0.814 0.000 2.256 [2.191 2.323]#

D031 Diseases due to other mycobacteria All subcodes 0.394 0.000 1.483 [1.444 1.524]^^

All subcodes except 0380, 03810, 03811, 03819,

0382, 03840, 03842, 03843, 03849, 0388 and

D038 Septicemia 0389 0.364 0.000 1.439 [1.405 1.473]^^

D0380 Streptococcal septicemia All subcodes 0.405 0.002 1.500 [1.484 1.516]#

D03810 Staphylococcal septicemia, unspecified None 0.467 0.001 1.595 [1.566 1.626]#

D03811 Methicillin susceptible Staphylococcus aureus septicemia None 0.457 0.005 1.579 [1.567 1.592]#

D03819 Other staphylococcal septicemia None 0.419 0.002 1.520 [1.502 1.539]#

D0382 Pneumococcal septicemia [Streptococcus pneumoniae septicemia] All subcodes 0.279 0.000 1.322 [1.290 1.354]^^

D03840 Septicemia due to gram-negative organism, unspecified None 0.356 0.001 1.428 [1.398 1.458]^^^

D03842 Septicemia due to escherichia coli [E. coli] None 0.313 0.003 1.367 [1.354 1.380]#

D03843 Septicemia due to pseudomonas None 0.430 0.001 1.537 [1.507 1.567]#

D03849 Other septicemia due to gram-negative organisms None 0.346 0.002 1.414 [1.398 1.430]#

D0388 Other specified septicemias All subcodes 0.407 0.001 1.502 [1.480 1.523]#

D0389 Unspecified septicemia All subcodes 0.237 0.020 1.268 [1.263 1.273]#



All subcodes except 04104, 04109, 04111, 04119,

D041 Bacterial infection in conditions classified elsewhere and of unspecified site 0413, 0414, 0416, 0417, 04185, and 04189 0.122 0.007 1.130 [1.124 1.137]#

Streptococcus infection in conditions classified elsewhere and of unspecified site, streptococcus,

D04104 group D [Enterococcus] None 0.237 0.005 1.268 [1.259 1.277]#

Streptococcus infection in conditions classified elsewhere and of unspecified site, other

D04109 streptococcus None 0.139 0.001 1.149 [1.132 1.167]^

Methicillin susceptible Staphylococcus aureus in conditions classified elsewhere and of

D04111 unspecified site None 0.237 0.010 1.268 [1.261 1.276]#

Staphylococcus infection in conditions classified elsewhere and of unspecified site, other

D04119 staphylococcus None 0.214 0.002 1.239 [1.225 1.252]#



D0413 Friedländer's bacillus infection in conditions classified elsewhere and of unspecified site All subcodes 0.146 0.004 1.157 [1.147 1.166]^^^



D0414 Escherichia coli [E. coli] infection in conditions classified elsewhere and of unspecified site All subcodes 0.114 0.012 1.121 [1.116 1.126]#



D0416 Proteus (mirabilis) (morganii) infection in conditions classified elsewhere and of unspecified site All subcodes 0.122 0.003 1.130 [1.119 1.141]^^

D0417 Pseudomonas infection in conditions classified elsewhere and of unspecified site All subcodes 0.320 0.004 1.377 [1.367 1.388]#

Other specified bacterial infections in conditions classified elsewhere and of unspecified site, other

D04185 gram-negative organisms None 0.146 0.002 1.157 [1.146 1.169]^^

Other specified bacterial infections in conditions classified elsewhere and of unspecified site, other

D04189 specified bacteria None 0.146 0.001 1.157 [1.139 1.175]^

D042 Human immunodeficiency virus [HIV] disease All subcodes 0.331 0.000 1.393 [1.352 1.435]^^

D053 Herpes zoster All subcodes except 05319 and 0539 0.373 0.000 1.452 [1.415 1.489]^^

D05319 Herpes zoster with other nervous system complications None 0.191 0.001 1.211 [1.193 1.229]^^

D0539 Herpes zoster without mention of complication All subcodes 0.299 0.001 1.348 [1.330 1.366]#

D054 Herpes simplex All subcodes 0.422 0.001 1.525 [1.500 1.551]#

D078 Other diseases due to viruses and Chlamydiae All subcodes 0.328 0.000 1.388 [1.341 1.438]^

D094 Neurosyphilis All subcodes 0.367 0.000 1.443 [1.406 1.482]^^



D112 Candidiasis All subcodes except 1120, 1122, 1125 and 11284 0.365 0.002 1.441 [1.426 1.457]#

D1120 Candidiasis of mouth All subcodes 0.403 0.006 1.496 [1.487 1.506]#

D1122 Candidiasis of other urogenital sites All subcodes 0.425 0.002 1.530 [1.513 1.548]#

D1125 Disseminated candidiasis All subcodes 0.687 0.001 1.988 [1.936 2.041]#

D11284 Candidal esophagitis None 0.275 0.002 1.317 [1.304 1.331]#

D141 Malignant neoplasm of tongue All subcodes 0.171 0.000 1.187 [1.161 1.213]^

D150 Malignant neoplasm of esophagus All subcodes except 1509 0.321 0.001 1.379 [1.358 1.401]#

D1509 Malignant neoplasm of esophagus, unspecified site All subcodes 0.134 0.001 1.143 [1.125 1.162]^

D151 Malignant neoplasm of stomach All subcodes except 1510 and 1519 0.575 0.001 1.778 [1.752 1.805]#

D1510 Malignant neoplasm of cardia All subcodes 0.374 0.001 1.454 [1.427 1.482]#

D1519 Malignant neoplasm of stomach, unspecified site All subcodes 0.297 0.001 1.346 [1.322 1.370]^^^

D152 Malignant neoplasm of small intestine, including duodenum All subcodes 0.316 0.001 1.372 [1.343 1.401]^^

All subcodes except 1530, 1531, 1532, 1533,

D153 Malignant neoplasm of colon 1534, 1536, 1538 and 1539 0.222 0.000 1.249 [1.221 1.277]^

D1530 Malignant neoplasm of hepatic flexure All subcodes 0.173 0.001 1.189 [1.166 1.213]^

D1531 Malignant neoplasm of transverse colon All subcodes 0.231 0.001 1.260 [1.240 1.282]^^

D1532 Malignant neoplasm of descending colon All subcodes 0.244 0.001 1.276 [1.251 1.302]^^

D1533 Malignant neoplasm of sigmoid colon All subcodes 0.268 0.003 1.308 [1.294 1.322]#

D1534 Malignant neoplasm of cecum All subcodes 0.170 0.003 1.185 [1.172 1.198]^^

D1536 Malignant neoplasm of ascending colon All subcodes 0.185 0.003 1.203 [1.189 1.216]^^^

D1538 Malignant neoplasm of other specified sites of large intestine All subcodes 0.255 0.001 1.290 [1.267 1.314]^^

D1539 Malignant neoplasm of colon, unspecified site All subcodes 0.120 0.004 1.127 [1.119 1.136]^^

D154 Malignant neoplasm of rectum, rectosigmoid junction and anus All subcodes except 1540 and 1541 0.318 0.000 1.374 [1.342 1.407]^^

D1540 Malignant neoplasm of rectosigmoid junction All subcodes 0.272 0.002 1.312 [1.295 1.328]#

D1541 Malignant neoplasm of rectum All subcodes 0.276 0.003 1.318 [1.303 1.332]#

D155 Malignant neoplasm of liver and intrahepatic bile ducts All subcodes 0.194 0.002 1.214 [1.199 1.229]^^^

D156 Malignant neoplasm of gallbladder and extrahepatic bile ducts All subcodes 0.378 0.001 1.460 [1.438 1.483]#

D157 Malignant neoplasm of pancreas All subcodes except 1570 and 1579 0.286 0.001 1.331 [1.310 1.353]^^^

D1570 Malignant neoplasm of head of pancreas All subcodes 0.386 0.001 1.471 [1.451 1.492]#

D1579 Malignant neoplasm of pancreas, part unspecified All subcodes 0.155 0.001 1.168 [1.153 1.183]^^

D158 Malignant neoplasm of retroperitoneum and peritoneum All subcodes 0.247 0.001 1.280 [1.252 1.308]^^

D161 Malignant neoplasm of larynx All subcodes 0.376 0.001 1.457 [1.432 1.483]#

D1623 Malignant neoplasm of upper lobe, bronchus or lung All subcodes 0.188 0.006 1.207 [1.199 1.216]#

D1625 Malignant neoplasm of lower lobe, bronchus or lung All subcodes 0.172 0.003 1.188 [1.177 1.199]^^^

D1628 Malignant neoplasm of other parts of bronchus or lung All subcodes 0.209 0.002 1.233 [1.220 1.247]#

D1629 Malignant neoplasm of bronchus and lung, unspecified All subcodes 0.089 0.009 1.093 [1.087 1.099]^^^

D163 Malignant neoplasm of pleura All subcodes 0.248 0.000 1.282 [1.245 1.320]^

D170 Malignant neoplasm of bone and articular cartilage All subcodes 0.417 0.000 1.517 [1.473 1.562]^^

D171 Malignant neoplasm of connective and other soft tissue All subcodes 0.312 0.001 1.366 [1.342 1.391]^^^

D173 Other malignant neoplasm of skin All subcodes 0.099 0.002 1.104 [1.091 1.118]^

D174 Malignant neoplasm of female breast All subcodes except 1744 -0.115 0.008 0.891 [0.885 0.896]#

D1744 Malignant neoplasm of upper-outer quadrant of female breast All subcodes -0.301 0.001 0.740 [0.729 0.751]#

D1820 Malignant neoplasm of corpus uteri, except isthmus All subcodes 0.091 0.003 1.095 [1.083 1.107]^

D183 Malignant neoplasm of ovary and other uterine adnexa All subcodes 0.131 0.003 1.140 [1.128 1.151]^^

D184 Malignant neoplasm of other and unspecified female genital organs All subcodes 0.358 0.000 1.430 [1.395 1.465]^^

D188 Malignant neoplasm of bladder All subcodes 0.027 0.007 1.027 [1.020 1.033]**

D189 Malignant neoplasm of kidney and other and unspecified urinary organs All subcodes except 1890 0.216 0.001 1.241 [1.219 1.264]^^

D1890 Malignant neoplasm of kidney, except pelvis All subcodes 0.192 0.003 1.212 [1.199 1.225]^^^

D191 Malignant neoplasm of brain All subcodes 0.355 0.001 1.426 [1.403 1.449]#

D195 Malignant neoplasm of other and ill-defined sites All subcodes 0.173 0.000 1.189 [1.163 1.215]^

D196 Secondary and unspecified malignant neoplasm of lymph nodes All subcodes except 1962 and 1966 0.102 0.006 1.107 [1.099 1.114]^^

D1962 Secondary and unspecified malignant neoplasm of intra-abdominal lymph nodes All subcodes 0.148 0.005 1.160 [1.151 1.168]#

D1966 Secondary and unspecified malignant neoplasm of intrapelvic lymph nodes All subcodes 0.143 0.001 1.154 [1.134 1.175]^

D1972 Secondary malignant neoplasm of pleura All subcodes 0.179 0.004 1.196 [1.186 1.206]#

D1974 Secondary malignant neoplasm of small intestine including duodenum All subcodes 0.166 0.001 1.181 [1.162 1.200]^

D1975 Secondary malignant neoplasm of large intestine and rectum All subcodes 0.137 0.001 1.147 [1.130 1.164]^

D1976 Secondary malignant neoplasm of retroperitoneum and peritoneum All subcodes 0.134 0.005 1.143 [1.133 1.152]^^^

D1977 Malignant neoplasm of liver, secondary All subcodes 0.093 0.011 1.097 [1.091 1.102]^^^

All subcodes except 1981, 1983, 1985 19882 and

D198 Secondary malignant neoplasm of other specified sites 19889 0.126 0.002 1.134 [1.123 1.146]^^

D1981 Secondary malignant neoplasm of other urinary organs All subcodes 0.156 0.001 1.169 [1.151 1.188]^









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al





Webtable 2C. RSILOS Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

D1983 Secondary malignant neoplasm of brain and spinal cord All subcodes 0.229 0.004 1.257 [1.247 1.268]#

D1985 Secondary malignant neoplasm of bone and bone marrow All subcodes 0.314 0.010 1.369 [1.362 1.376]#

D19882 Secondary malignant neoplasm of genital organs None 0.118 0.001 1.125 [1.107 1.142]^

D19889 Secondary malignant neoplasm of other specified sites None 0.176 0.004 1.193 [1.184 1.202]#

D1991 Other malignant neoplasm without specification of site All subcodes 0.117 0.004 1.124 [1.115 1.133]^^



D200 Lymphosarcoma and reticulosarcoma and other specified malignant tumors of lymphatic tissue All subcodes except 2000 0.200 0.000 1.222 [1.194 1.251]^

D2000 Reticulosarcoma All subcodes 0.252 0.001 1.286 [1.267 1.306]^^^

D201 Hodgkins disease All subcodes 0.204 0.000 1.226 [1.199 1.254]^

D2028 Other lymphomas All subcodes except 20280 and 20283 0.237 0.002 1.267 [1.252 1.283]#

D20280 Other malignant lymphomas, unspecified site, extranodal and solid organ sites None 0.148 0.005 1.159 [1.151 1.168]#

D20283 Other malignant lymphomas, intra-abdominal lymph nodes None 0.250 0.001 1.284 [1.262 1.305]^^

D20300 Multiple myeloma, without mention of having achieved remission None 0.218 0.004 1.243 [1.233 1.253]#

D204 Lymphoid leukemia All subcodes except 20410 0.222 0.001 1.249 [1.224 1.275]^^

D20410 Chronic lymphoid leukemia, without mention of having achieved remission None 0.145 0.004 1.156 [1.147 1.165]^^^

D205 Myeloid leukemia All subcodes except 20500 and 20510 0.391 0.000 1.478 [1.436 1.521]^^

D20500 Acute myeloid leukemia, without mention of having achieved remission None 0.612 0.002 1.844 [1.819 1.869]#

D20510 Chronic myeloid leukemia, without mention of having achieved remission None 0.195 0.001 1.215 [1.194 1.237]^^

D211 Benign neoplasm of other parts of digestive system All subcodes except 2113 and 2114 0.120 0.003 1.128 [1.118 1.139]^^

D2113 Benign neoplasm of colon All subcodes 0.070 0.015 1.072 [1.066 1.078]^^

D2114 Benign neoplasm of rectum and anal canal All subcodes 0.088 0.001 1.092 [1.079 1.106]***

D212 Benign neoplasm of respiratory and intrathoracic organs All subcodes 0.248 0.000 1.281 [1.247 1.316]^

D220 Benign neoplasm of ovary All subcodes 0.119 0.002 1.126 [1.112 1.140]^

D225 Benign neoplasm of brain and other parts of nervous system All subcodes except 2252 0.349 0.000 1.417 [1.379 1.457]^^

D2252 Benign neoplasm of cerebral meninges All subcodes 0.348 0.001 1.416 [1.395 1.438]#

D227 Benign neoplasm of other endocrine glands and related structures All subcodes 0.186 0.001 1.205 [1.185 1.224]^^

D230 Carcinoma in situ of digestive organs All subcodes 0.266 0.000 1.305 [1.276 1.335]^^

D2330 Carcinoma in situ of breast All subcodes -0.297 0.001 0.743 [0.731 0.755]^^^

D2352 Neoplasm of uncertain behavior of stomach, intestines, and rectum All subcodes 0.189 0.001 1.208 [1.190 1.225]^^

D238 Neoplasm of uncertain behavior of other and unspecified sites and tissues All subcodes except 2387 0.060 0.006 1.062 [1.056 1.069]^

D242 Thyrotoxicosis with or without goiter All subcodes except 24290 0.182 0.001 1.200 [1.183 1.218]^^

Thyrotoxicosis without mention of goiter or other cause, and without mention of thyrotoxic crisis

D24290 or storm None 0.154 0.002 1.167 [1.155 1.180]^^

D2449 Unspecified acquired hypothyroidism All subcodes 0.041 0.092 1.042 [1.040 1.043]#



All subcodes except 25000, 25001, 25002, 25003,

2501, 2502, 25040, 25041, 25042, 25043, 25060,

25061, 25062, 25070, 25072, 25080, 25081,

D250 Diabetes mellitus 25082, 25083 and 25092 0.151 0.008 1.163 [1.157 1.170]#

Diabetes mellitus without mention of complication, type II or unspecified type, not stated as

D25000 uncontrolled None 0.062 0.168 1.064 [1.063 1.066]#

Diabetes mellitus without mention of complication, type I [juvenile type], not stated as

D25001 uncontrolled None 0.166 0.012 1.180 [1.175 1.185]#



D25002 Diabetes mellitus without mention of complication, type II or unspecified type, uncontrolled None 0.334 0.011 1.396 [1.390 1.403]#



D25003 Diabetes mellitus without mention of complication, type I [juvenile type], uncontrolled None 0.447 0.001 1.564 [1.542 1.586]#

D2501 Diabetes with ketoacidosis All subcodes 0.290 0.001 1.337 [1.315 1.360]^^^

D2502 Diabetes with hyperosmolarity All subcodes 0.276 0.001 1.318 [1.290 1.347]^^



D25040 Diabetes with renal manifestations, type II or unspecified type, not stated as uncontrolled None 0.116 0.012 1.123 [1.118 1.129]#



D25041 Diabetes with renal manifestations, type I [juvenile type], not stated as uncontrolled None 0.207 0.002 1.230 [1.216 1.244]^^^

D25042 Diabetes with renal manifestations, type II or unspecified type, uncontrolled None 0.279 0.002 1.322 [1.307 1.338]#

D25043 Diabetes with renal manifestations, type I [juvenile type], uncontrolled None 0.421 0.000 1.524 [1.481 1.568]^^



D25060 Diabetes with neurological manifestations, type II or unspecified type, not stated as uncontrolled None 0.106 0.013 1.112 [1.104 1.120]^^



D25061 Diabetes with neurological manifestations, type I [juvenile type], not stated as uncontrolled None 0.167 0.002 1.182 [1.168 1.196]^^



D25062 Diabetes with neurological manifestations, type II or unspecified type, uncontrolled None 0.227 0.002 1.255 [1.240 1.270]#

Diabetes with peripheral circulatory disorders, type II or unspecified type, not stated as

D25070 uncontrolled None 0.186 0.005 1.205 [1.196 1.214]#



D25072 Diabetes with peripheral circulatory disorders, type II or unspecified type, uncontrolled None 0.313 0.001 1.368 [1.346 1.392]^^^

Diabetes with other specified manifestations, type II or unspecified type, not stated as

D25080 uncontrolled None 0.176 0.008 1.193 [1.186 1.199]#



D25081 Diabetes with other specified manifestations, type I [juvenile type], not stated as uncontrolled None 0.213 0.001 1.237 [1.219 1.255]^^



D25082 Diabetes with other specified manifestations, type II or unspecified type, uncontrolled None 0.299 0.002 1.349 [1.332 1.365]#

D25083 Diabetes with other specified manifestations, type I [juvenile type], uncontrolled None 0.394 0.000 1.483 [1.440 1.528]^^

D25092 Diabetes with unspecified complication, type II or unspecified type, uncontrolled None 0.289 0.001 1.335 [1.315 1.357]^^^

D2518 Other specified disorders of pancreatic internal secretion All subcodes 0.302 0.001 1.352 [1.334 1.369]#

D2520 Hyperparathyroidism All subcodes 0.114 0.002 1.121 [1.106 1.136]^

D253 Disorders of the pituitary gland and its hypothalamic control All subcodes except 2536 0.205 0.001 1.228 [1.206 1.251]^^

D2536 Other disorders of neurohypophysis All subcodes 0.415 0.003 1.515 [1.501 1.530]#

D255 Disorders of adrenal glands All subcodes 0.174 0.003 1.190 [1.179 1.201]^^^

D260 Kwashiorkor All subcodes 0.391 0.001 1.478 [1.452 1.504]#

D261 Nutritional marasmus All subcodes 0.286 0.002 1.331 [1.315 1.348]#

D262 Other severe protein-calorie malnutrition All subcodes 0.409 0.001 1.506 [1.473 1.539]^^^

D263 Other and unspecified protein-calorie malnutrition All subcodes except 2631, 2638 and 2639 0.354 0.000 1.425 [1.391 1.460]^^

D2631 Malnutrition of mild degree All subcodes 0.321 0.001 1.378 [1.348 1.408]^^

D2638 Other protein-calorie malnutrition All subcodes 0.281 0.001 1.324 [1.306 1.341]#

D2639 Unspecified protein-calorie malnutrition All subcodes 0.340 0.028 1.405 [1.400 1.409]#

D2662 Other B-complex deficiencies All subcodes 0.117 0.003 1.124 [1.114 1.135]^^

D2720 Pure hypercholesterolemia All subcodes -0.062 0.073 0.940 [0.938 0.941]#

D2722 Mixed hyperlipidemia All subcodes -0.095 0.001 0.909 [0.894 0.924]***

D2724 Other and unspecified hyperlipidemia All subcodes -0.094 0.119 0.910 [0.908 0.911]#

D2729 Unspecified disorder of lipoid metabolism All subcodes -0.198 0.002 0.820 [0.811 0.829]^^^

D273 Disorders of plasma protein metabolism All subcodes 0.165 0.004 1.179 [1.170 1.188]#

D2740 Gouty arthropathy All subcodes 0.201 0.004 1.223 [1.213 1.233]#

D2749 Gout, unspecified All subcodes 0.049 0.013 1.050 [1.046 1.054]^^

D2752 Disorders of magnesium metabolism All subcodes 0.112 0.005 1.118 [1.110 1.125]^^^

D27541 Hypocalcemia None 0.125 0.003 1.133 [1.122 1.144]^^

D27542 Hypercalcemia None 0.268 0.003 1.308 [1.296 1.321]#

D2760 Hyperosmolality and/or hypernatremia All subcodes 0.154 0.008 1.166 [1.159 1.172]#

D2761 Hyposmolality and/or hyponatremia All subcodes 0.237 0.044 1.268 [1.265 1.271]#

D2762 Acidosis All subcodes 0.115 0.013 1.122 [1.117 1.127]#

D2763 Alkalosis All subcodes 0.226 0.003 1.254 [1.243 1.266]#

D2765 Volume depletion All subcodes 0.151 0.086 1.163 [1.161 1.166]#

D2766 Fluid overload disorder All subcodes 0.159 0.006 1.172 [1.165 1.179]#

D2767 Hyperpotassemia All subcodes 0.166 0.025 1.180 [1.176 1.183]#

D2768 Hypopotassemia All subcodes 0.165 0.043 1.179 [1.176 1.182]#

D2769 Electrolyte and fluid disorders not elsewhere classified All subcodes 0.178 0.005 1.195 [1.186 1.203]#

D2780 Overweight and obesity All subcodes 0.050 0.029 1.051 [1.047 1.054]^^^

D2800 Iron deficiency anemia secondary to blood loss (chronic) All subcodes 0.087 0.034 1.091 [1.088 1.094]#

D2809 Iron deficiency anemia, unspecified All subcodes 0.088 0.018 1.092 [1.088 1.096]#









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al





Webtable 2C. RSILOS Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

D282 Hereditary hemolytic anemias All subcodes 0.125 0.001 1.133 [1.116 1.150]^

D283 Acquired hemolytic anemias All subcodes 0.285 0.001 1.330 [1.312 1.348]#

D2848 Other specified aplastic anemias All subcodes 0.291 0.009 1.338 [1.330 1.345]#

D285 Other and unspecified anemias All subcodes 0.124 0.172 1.132 [1.131 1.134]#



D286 Coagulation defects All subcodes except 2865, 2866, 2867 and 2869 0.267 0.001 1.306 [1.284 1.328]^^^

D2865 Hemorrhagic disorder due to intrinsic circulating anticoagulants All subcodes 0.214 0.001 1.239 [1.217 1.261]^^

D2866 Defibrination syndrome All subcodes 0.295 0.001 1.343 [1.318 1.369]^^

D2867 Acquired coagulation factor deficiency All subcodes 0.183 0.002 1.201 [1.188 1.214]^^^

D2869 Other and unspecified coagulation defects All subcodes 0.191 0.005 1.211 [1.203 1.219]#

D2873 Primary thrombocytopenia All subcodes 0.241 0.002 1.273 [1.258 1.288]#

D2874 Secondary thrombocytopenia All subcodes 0.227 0.004 1.255 [1.245 1.265]#

D2875 Thrombocytopenia, unspecified All subcodes 0.148 0.017 1.160 [1.155 1.164]#

D2880 Neutropenia All subcodes 0.315 0.005 1.370 [1.360 1.379]#

D2888 Other specified disease of white blood cells All subcodes 0.139 0.006 1.149 [1.142 1.157]#

D2898 Other specified diseases of blood and blood-forming organs All subcodes 0.124 0.002 1.132 [1.120 1.145]^^



D290 Dementias All subcodes except 2900, 2903, 2904 and 29040 0.644 0.001 1.905 [1.873 1.936]#

D2900 Senile dementia, uncomplicated All subcodes 0.240 0.006 1.271 [1.263 1.278]#

D2903 Senile dementia with delirium All subcodes 0.465 0.001 1.592 [1.564 1.620]#

D2904 Vascular dementia All subcodes 0.606 0.001 1.833 [1.799 1.867]#

D29040 Vascular dementia, uncomplicated None 0.240 0.004 1.271 [1.259 1.284]#

D291 Alcohol-induced mental disorders All subcodes except 2910 and 2918 0.467 0.001 1.595 [1.565 1.625]#

D2910 Alcohol withdrawal delirium All subcodes 0.434 0.001 1.544 [1.519 1.569]#

D2918 Other specified alcohol-induced mental disorders All subcodes 0.252 0.002 1.286 [1.269 1.303]#

D292 Drug-induced mental disorders All subcodes except 2928 0.266 0.001 1.305 [1.286 1.325]^^^

D2928 Other specified drug-induced mental disorders All subcodes 0.275 0.004 1.317 [1.306 1.327]#

D2930 Delirium due to conditions classified elsewhere All subcodes 0.287 0.005 1.332 [1.323 1.341]#

D2938 Other specified transient mental disorders due to conditions classified elsewhere All subcodes 0.551 0.001 1.735 [1.699 1.772]#

D2939 Unspecified transient mental disorder in conditions classified elsewhere All subcodes 0.251 0.001 1.285 [1.269 1.301]#

D2941 Dementia in conditions classified elsewhere All subcodes 0.161 0.020 1.175 [1.169 1.182]#

D2948 Other persistent mental disorders due to conditions classified elsewhere All subcodes 0.186 0.031 1.205 [1.202 1.208]#

D2949 Unspecified persistent mental disorders due to conditions classified elsewhere All subcodes 0.332 0.001 1.394 [1.371 1.419]#

All subcodes except 29530, 29534, 2957, 29570

D295 Schizophrenic disorders and 29590 0.576 0.001 1.779 [1.750 1.809]#

D29530 Paranoid type schizophrenia, unspecified None 0.485 0.001 1.624 [1.591 1.658]#

D29534 Paranoid type schizophrenia, chronic with acute exacerbation None 1.490 0.000 4.439 [4.233 4.654]#

D2957 Schizoaffective disorder All subcodes except 29570 1.030 0.000 2.800 [2.692 2.913]#

D29570 Schizoaffective disorder, unspecified None 0.578 0.001 1.783 [1.752 1.815]#

D29590 Unspecified schizophrenia, unspecified None 0.226 0.002 1.253 [1.240 1.267]#



All subcodes except 2962, 29620, 29630, 29633,

D296 Episodic mood disorders 29634, 2964, 29650, 2966 and 2967 0.409 0.002 1.506 [1.489 1.524]#

D2962 Major depressive disorder, single episode All subcodes except 29620 0.811 0.001 2.251 [2.214 2.289]#

D29620 Major depressive affective disorder, single episode, unspecified None 0.541 0.002 1.718 [1.699 1.737]#

D29630 Major depressive affective disorder, recurrent episode, unspecified None 0.687 0.001 1.987 [1.953 2.021]#

Major depressive affective disorder, recurrent episode, severe, without mention of psychotic

D29633 behavior None 0.860 0.001 2.362 [2.322 2.403]#

Major depressive affective disorder, recurrent episode, severe, specified as with psychotic

D29634 behavior None 1.018 0.001 2.768 [2.710 2.828]#

D2964 Bipolar I disorder, most recent episode (or current) manic All subcodes 1.316 0.000 3.727 [3.610 3.849]#

D29650 Bipolar I disorder, most recent episode (or current) depressed, unspecified None 0.655 0.000 1.925 [1.867 1.984]#

D2966 Bipolar I disorder, most recent episode (or current) mixed All subcodes 1.083 0.000 2.953 [2.836 3.074]#

D2967 Bipolar I disorder, most recent episode (or current) unspecified All subcodes 0.289 0.002 1.335 [1.320 1.351]#

D297 Delusional disorders All subcodes 0.611 0.001 1.842 [1.805 1.880]#

D298 Other nonorganic psychoses All subcodes except 2989 0.445 0.000 1.561 [1.506 1.619]^^

D2989 Unspecified psychosis All subcodes 0.375 0.006 1.455 [1.446 1.465]#

D300 Anxiety, dissociative and somatoform disorders All subcodes except 30000, 3004 and 3009 0.133 0.002 1.142 [1.129 1.154]^^

D30000 Anxiety state, unspecified None 0.093 0.017 1.098 [1.094 1.102]#

D3004 Dysthymic disorder All subcodes 0.129 0.009 1.138 [1.132 1.144]#

D3009 Unspecified nonpsychotic mental disorder All subcodes 0.249 0.000 1.283 [1.254 1.313]^

D301 Personality disorders All subcodes except 3018 0.400 0.000 1.492 [1.457 1.528]^^^

D3018 Other personality disorders All subcodes 0.473 0.000 1.605 [1.532 1.682]^

D303 Alcohol dependence syndrome All subcodes except 30390 0.152 0.004 1.164 [1.154 1.174]^^^

D30390 Other and unspecified alcohol dependence, unspecified None 0.169 0.003 1.184 [1.173 1.195]^^^

D304 Drug dependence All subcodes 0.235 0.001 1.265 [1.244 1.285]^^

D3051 Tobacco use disorder All subcodes -0.082 0.038 0.921 [0.918 0.923]#

D307 Special symptoms or syndromes, not elsewhere classified All subcodes except 3079 0.154 0.000 1.166 [1.138 1.195]***

D3079 Other and unspecified special symptoms or syndromes, not elsewhere classified All subcodes 0.287 0.001 1.332 [1.309 1.355]^^^

D309 Adjustment reaction All subcodes except 3090 0.434 0.001 1.543 [1.517 1.569]#

D3090 Adjustment disorder with depressed mood All subcodes 0.393 0.001 1.481 [1.455 1.508]#

D310 Specific nonpsychotic mental disorders due to brain damage All subcodes except 3109 0.468 0.000 1.597 [1.562 1.633]#

D3109 Unspecified nonpsychotic mental disorder following organic brain damage All subcodes 0.261 0.002 1.298 [1.283 1.314]#

D311 Depressive disorder, not elsewhere classified All subcodes 0.128 0.035 1.136 [1.133 1.139]#

D312 Disturbance of conduct, not elsewhere classified All subcodes 0.668 0.000 1.950 [1.886 2.016]#

D319 Unspecified mental retardation All subcodes 0.166 0.001 1.181 [1.162 1.201]^

D320 Bacterial meningitis All subcodes 0.492 0.000 1.636 [1.584 1.689]^^

D322 Meningitis of unspecified cause All subcodes 0.304 0.000 1.355 [1.317 1.395]^

D323 Encephalitis, myelitis, and encephalomyelitis All subcodes 0.485 0.000 1.624 [1.573 1.677]^^

D324 Intracranial and intraspinal abscess All subcodes 0.585 0.000 1.795 [1.752 1.840]#

D331 Other cerebral degenerations All subcodes except 3310, 3313 and 3314 0.133 0.002 1.142 [1.128 1.155]^^

D3310 Alzheimer's disease All subcodes 0.142 0.025 1.153 [1.147 1.158]#

D3313 Communicating hydrocephalus All subcodes 0.337 0.002 1.401 [1.383 1.419]#

D3314 Obstructive hydrocephalus All subcodes 0.376 0.002 1.457 [1.438 1.477]#

D3320 Paralysis agitans All subcodes 0.154 0.016 1.167 [1.162 1.171]#

D333 Other extrapyramidal disease and abnormal movement disorders All subcodes 0.073 0.005 1.076 [1.069 1.083]^^

D334 Spinocerebellar disease All subcodes 0.203 0.000 1.225 [1.185 1.266]***

D336 Other diseases of spinal cord All subcodes 0.413 0.001 1.512 [1.487 1.536]#

D337 Disorders of the autonomic nervous system All subcodes 0.137 0.002 1.147 [1.134 1.160]^^

D342 Hemiplegia and hemiparesis All subcodes except 3429 and 34290 0.309 0.001 1.362 [1.338 1.386]^^^

D3429 Hemiplegia, unspecified All subcodes 0.399 0.001 1.491 [1.467 1.515]#

D34290 Hemiplegia, unspecified, affecting unspecified side None 0.280 0.006 1.323 [1.314 1.333]#

D344 Other paralytic syndromes All subcodes except 3441 0.327 0.002 1.387 [1.373 1.401]#

D3441 Paraplegia All subcodes 0.311 0.001 1.365 [1.346 1.385]#

D345 Epilepsy and recurrent seizures All subcodes except 3453 0.196 0.001 1.216 [1.197 1.236]^^

D3453 Grand mal status All subcodes 0.235 0.000 1.265 [1.233 1.298]^

D348 Cerebral cysts All subcodes except 3481 and 3483 0.209 0.001 1.233 [1.214 1.252]^^

D3481 Anoxic brain damage All subcodes 0.290 0.002 1.337 [1.319 1.355]#

D3483 Encephalopathy, not elsewhere classified All subcodes 0.365 0.004 1.440 [1.429 1.451]#

D349 Other and unspecified disorders of the nervous system All subcodes except 34982 0.242 0.001 1.274 [1.248 1.300]^^

D34982 Toxic encephalopathy None 0.322 0.001 1.380 [1.360 1.400]#

D355 Mononeuritis of lower limb All subcodes except 3558 0.099 0.001 1.104 [1.090 1.119]^

D3558 Mononeuritis of lower limb, unspecified All subcodes 0.135 0.001 1.145 [1.131 1.160]^

D3569 Unspecified hereditary and idiopathic peripheral neuropathy All subcodes 0.093 0.006 1.097 [1.090 1.104]^^

D357 Inflammatory and toxic neuropathy All subcodes except 3572 0.362 0.001 1.436 [1.415 1.457]#

D3572 Polyneuropathy in diabetes All subcodes 0.073 0.011 1.076 [1.067 1.084]^

D3580 Myasthenia gravis All subcodes 0.213 0.001 1.238 [1.221 1.256]^^

D359 Muscular dystrophies and other myopathies All subcodes 0.259 0.001 1.295 [1.272 1.318]^^









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al





Webtable 2C. RSILOS Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

D360 Disorders of the globe All subcodes 0.345 0.000 1.412 [1.358 1.468]^

D365 Glaucoma All subcodes 0.035 0.015 1.036 [1.032 1.041]^

D368 Visual disturbances All subcodes 0.135 0.002 1.145 [1.133 1.157]^^

D3694 Legal blindness, as defined in U.S.A. All subcodes 0.132 0.002 1.141 [1.127 1.154]^^

D372 Disorders of conjunctiva All subcodes except 3723 0.260 0.000 1.297 [1.268 1.327]^^

D3723 Other and unspecified conjunctivitis All subcodes 0.293 0.001 1.340 [1.317 1.364]^^^

D380 Disorders of external ear All subcodes 0.363 0.001 1.438 [1.407 1.469]^^^

D381 Nonsuppurative otitis media and Eustachian tube disorders All subcodes 0.498 0.000 1.645 [1.574 1.719]^^

D3861 Other and unspecified peripheral vertigo All subcodes 0.113 0.001 1.120 [1.103 1.137]***

D388 Other disorders of ear All subcodes 0.148 0.001 1.159 [1.137 1.182]***

D3962 Mitral valve insufficiency and aortic valve stenosis All subcodes 0.080 0.004 1.083 [1.074 1.091]^

D3963 Mitral valve insufficiency and aortic valve insufficiency All subcodes 0.072 0.008 1.075 [1.069 1.081]^^

D3970 Diseases of tricuspid valve All subcodes 0.109 0.013 1.115 [1.110 1.120]#

D39891 Rheumatic heart failure (congestive) None 0.277 0.005 1.319 [1.309 1.329]#

D4010 Malignant essential hypertension All subcodes 0.254 0.003 1.289 [1.277 1.301]#

D4019 Unspecified essential hypertension All subcodes 0.036 0.458 1.037 [1.036 1.038]#

D402 Hypertensive heart disease All subcodes except 40290 and 40291 0.244 0.001 1.276 [1.253 1.301]^^

D40290 Unspecified hypertensive heart disease without heart failure None 0.161 0.012 1.175 [1.170 1.180]#

D40291 Unspecified hypertensive heart disease with heart failure None 0.272 0.009 1.313 [1.306 1.320]#

Hypertensive chronic kidney disease, malignant, with chronic kidney disease stage V or end stage

D40301 renal disease None 0.305 0.001 1.356 [1.334 1.379]^^^

Hypertensive chronic kidney disease, unspecified, with chronic kidney disease stage I through

D40390 stage IV, or unspecified None 0.161 0.002 1.175 [1.163 1.186]^^^

Hypertensive chronic kidney disease, unspecified, with chronic kidney disease stage V or end

D40391 stage renal disease None 0.138 0.065 1.148 [1.145 1.151]#

D404 Hypertensive heart and chronic kidney disease All subcodes except 40492 and 40493 0.365 0.001 1.441 [1.419 1.464]#

Hypertensive heart and chronic kidney disease, unspecified, without heart failure and with

D40492 chronic kidney disease stage V or end stage renal disease None 0.252 0.002 1.286 [1.271 1.301]#

Hypertensive heart and chronic kidney disease, unspecified, with heart failure and chronic kidney

D40493 disease stage V or end stage renal disease None 0.321 0.004 1.379 [1.368 1.390]#



All subcodes except 41001, 41011, 41021, 41031,

D410 Acute myocardial infarction 41041, 41051, 41071, 41081, 41090 and 41091 0.143 0.004 1.154 [1.145 1.162]#

D41001 Acute myocardial infarction of anterolateral wall, initial episode of care None 0.480 0.001 1.616 [1.593 1.639]#

D41011 Acute myocardial infarction of other anterior wall, initial episode of care None 0.507 0.005 1.661 [1.649 1.673]#

D41021 Acute myocardial infarction of inferolateral wall, initial episode of care None 0.423 0.001 1.527 [1.502 1.552]#

D41031 Acute myocardial infarction of inferoposterior wall, initial episode of care None 0.430 0.001 1.537 [1.509 1.566]#

D41041 Acute myocardial infarction of other inferior wall, initial episode of care None 0.430 0.006 1.538 [1.528 1.549]#

D41051 Acute myocardial infarction of other lateral wall, initial episode of care None 0.371 0.001 1.449 [1.422 1.476]#

D41071 Subendocardial infarction, initial episode of care None 0.365 0.032 1.441 [1.437 1.445]#

D41081 Acute myocardial infarction of other specified sites, initial episode of care None 0.344 0.001 1.410 [1.390 1.430]#

D41090 Acute myocardial infarction of unspecified site, episode of care unspecified None 0.156 0.002 1.169 [1.156 1.182]^^

D41091 Acute myocardial infarction of unspecified site, initial episode of care None 0.211 0.007 1.235 [1.228 1.242]#

D411 Other acute and subacute forms of ischemic heart disease All subcodes except 4111 and 41181 0.128 0.002 1.136 [1.123 1.149]^^

D4111 Intermediate coronary syndrome All subcodes 0.101 0.046 1.106 [1.103 1.109]#

D41181 Acute coronary occlusion without myocardial infarction None 0.165 0.000 1.179 [1.153 1.205]***

D412 Old myocardial infarction All subcodes -0.028 0.052 0.972 [0.970 0.974]^^

D414 Other forms of chronic ischemic heart disease All subcodes 0.032 0.313 1.033 [1.032 1.035]#

D41511 Iatrogenic pulmonary embolism and infarction None * 0.605 0.001 1.831 [1.802 1.861]#

D41519 Other pulmonary embolism and infarction None 0.459 0.007 1.583 [1.573 1.593]#

D4160 Primary pulmonary hypertension All subcodes 0.202 0.002 1.224 [1.210 1.237]^^^

D4168 Other chronic pulmonary heart diseases All subcodes 0.089 0.012 1.093 [1.088 1.098]#

D4169 Chronic pulmonary heart disease, unspecified All subcodes 0.213 0.003 1.238 [1.226 1.250]#

D420 Acute pericarditis All subcodes except 42090 0.258 0.000 1.294 [1.261 1.329]^

D42090 Acute pericarditis, unspecified None 0.205 0.001 1.227 [1.204 1.251]^

D4210 Acute and subacute bacterial endocarditis All subcodes 0.500 0.001 1.649 [1.627 1.672]#

D423 Other diseases of pericardium All subcodes except 4239 0.163 0.001 1.177 [1.155 1.199]^

D4239 Unspecified disease of pericardium All subcodes 0.163 0.002 1.177 [1.164 1.191]^^

D4240 Mitral valve disorders All subcodes 0.079 0.040 1.082 [1.079 1.085]#

D4241 Aortic valve disorders All subcodes 0.081 0.030 1.084 [1.081 1.087]#

D4242 Tricuspid valve disorders, specified as nonrheumatic All subcodes 0.156 0.003 1.169 [1.158 1.180]^^^

D42490 Endocarditis, valve unspecified, unspecified cause None 0.150 0.002 1.162 [1.148 1.177]^^

D4251 Hypertrophic obstructive cardiomyopathy All subcodes 0.135 0.001 1.144 [1.127 1.162]^

D4254 Other primary cardiomyopathies All subcodes 0.129 0.033 1.138 [1.134 1.141]#

All subcodes except 42731, 42732, 42741, 42781

D427 Cardiac dysrhythmias and 42789 0.205 0.038 1.227 [1.224 1.231]#

D42731 Atrial fibrillation None 0.203 0.181 1.225 [1.223 1.227]#

D42732 Atrial flutter None 0.194 0.016 1.214 [1.209 1.219]#

D42741 Ventricular fibrillation None 0.187 0.002 1.206 [1.194 1.219]^^^

D42781 Sinoatrial node dysfunction None 0.088 0.020 1.092 [1.087 1.096]#

D42789 Other specified cardiac dysrhythmias None 0.079 0.033 1.082 [1.079 1.085]#

D428 Heart Failure All subcodes 0.276 0.208 1.318 [1.316 1.320]#

D4292 Cardiovascular disease, unspecified All subcodes 0.128 0.004 1.137 [1.129 1.146]^^^

D430 Subarachnoid hemorrhage All subcodes 0.684 0.001 1.982 [1.946 2.018]#

D431 Intracerebral hemorrhage All subcodes 0.532 0.003 1.703 [1.686 1.720]#

D432 Other and unspecified intracranial hemorrhage All subcodes except 4321 0.347 0.000 1.415 [1.377 1.455]^^

D4321 Subdural hemorrhage All subcodes 0.293 0.002 1.340 [1.323 1.357]#

D433 Occlusion and stenosis of precerebral arteries All subcodes except 43310 and 43311 0.121 0.007 1.129 [1.123 1.136]#

D43310 Occlusion and stenosis of carotid artery without mention of cerebral infarction None -0.102 0.023 0.903 [0.900 0.906]#

D43311 Occlusion and stenosis of carotid artery with cerebral infarction None 0.544 0.001 1.723 [1.700 1.746]#



D434 Occlusion of cerebral arteries All subcodes except 4340, 43411 and 43491 0.328 0.000 1.388 [1.358 1.419]^^

D4340 Cerebral thrombosis All subcodes 0.330 0.001 1.391 [1.361 1.422]^^

D43411 Cerebral embolism with cerebral infarction None 0.381 0.003 1.464 [1.450 1.479]#

D43491 Cerebral artery occlusion, unspecified with cerebral infarction None 0.380 0.014 1.462 [1.455 1.469]#

D435 Transient cerebral ischemia All subcodes except 4359 0.173 0.001 1.189 [1.174 1.204]^^

D4359 Unspecified transient cerebral ischemia All subcodes 0.200 0.009 1.222 [1.215 1.228]#

D436 Acute, but ill-defined, cerebrovascular disease All subcodes 0.282 0.010 1.326 [1.319 1.333]#

D437 Other and ill-defined cerebrovascular disease All subcodes except 4370 0.131 0.004 1.140 [1.132 1.149]^^^

D4370 Cerebral atherosclerosis All subcodes 0.094 0.004 1.099 [1.088 1.110]^

All subcodes except 4381, 43811, 43820, 43821

D438 Late effects of cerebrovascular disease and 43822 0.171 0.012 1.187 [1.182 1.193]#

D4381 Speech and language deficits All subcodes except 43811 0.233 0.002 1.263 [1.248 1.279]#

D43811 Late effects of cerebrovascular disease, aphasia None 0.137 0.004 1.147 [1.137 1.156]^^^

D43820 Late effects of cerebrovascular disease, hemiplegia affecting unspecified side None 0.293 0.012 1.341 [1.334 1.347]#

D43821 Late effects of cerebrovascular disease, hemiplegia affecting dominant side None 0.475 0.001 1.608 [1.580 1.637]#

D43822 Late effects of cerebrovascular disease, hemiplegia affecting nondominant side None 0.481 0.001 1.617 [1.589 1.646]#

D44021 Atherosclerosis of native arteries of the extremities with intermittent claudication None -0.269 0.006 0.764 [0.759 0.769]#

D44022 Atherosclerosis of native arteries of the extremities with rest pain None 0.157 0.002 1.170 [1.157 1.184]^^

D44023 Atherosclerosis of native arteries of the extremities with ulceration None 0.154 0.004 1.167 [1.157 1.177]^^^

D44024 Atherosclerosis of native arteries of the extremities with gangrene None 0.344 0.007 1.411 [1.401 1.421]#

D441 Aortic aneurysm and dissection All subcodes except 4410 and 4414 0.148 0.003 1.159 [1.148 1.171]^^

D4410 Dissection of aorta All subcodes 0.397 0.001 1.488 [1.462 1.514]#

D4414 Abdominal aneurysm without mention of rupture All subcodes 0.059 0.013 1.061 [1.056 1.066]^^

D443 Other peripheral vascular disease All subcodes 0.054 0.043 1.056 [1.054 1.059]#

D444 Arterial embolism and thrombosis All subcodes except 44422 0.209 0.003 1.232 [1.219 1.244]#

D44422 Arterial embolism and thrombosis of lower extremity None 0.237 0.004 1.268 [1.258 1.279]#

D445 Atheroembolism All subcodes 0.269 0.000 1.309 [1.266 1.354]^









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al





Webtable 2C. RSILOS Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

D446 Polyarteritis nodosa and allied conditions All subcodes 0.145 0.002 1.156 [1.145 1.168]^^

D451 Phlebitis and thrombophlebitis All subcodes except 4511 and 4518 0.343 0.001 1.409 [1.384 1.434]#

D4511 Phlebitis and thrombophlebitis of deep vessels of lower extremities All subcodes 0.487 0.001 1.627 [1.595 1.660]#

D4518 Phlebitis and thrombophlebitis of other sites All subcodes 0.355 0.001 1.426 [1.403 1.448]#

D453 Other venous embolism and thrombosis All subcodes 0.449 0.017 1.567 [1.560 1.573]#

D4571 Other lymphedema All subcodes 0.207 0.001 1.230 [1.210 1.250]^^

D4580 Orthostatic hypotension All subcodes 0.222 0.006 1.249 [1.241 1.257]#

D4588 Other specified hypotension All subcodes 0.074 0.002 1.077 [1.065 1.089]***

D4589 Hypotension, unspecified All subcodes 0.095 0.016 1.100 [1.096 1.104]#

D459 Other disorders of circulatory system All subcodes except 45981 and 45989 0.278 0.003 1.321 [1.309 1.333]#

D45981 Venous (peripheral) insufficiency, unspecified None 0.137 0.006 1.147 [1.140 1.155]#

D45989 Other specified disorders of circulatory system None 0.147 0.001 1.158 [1.139 1.178]^

D461 Acute sinusitis All subcodes 0.235 0.001 1.265 [1.241 1.289]^^

D464 Acute laryngitis and tracheitis All subcodes 0.199 0.000 1.220 [1.187 1.253]***

D4659 Acute upper respiratory infections of unspecified site All subcodes 0.178 0.002 1.195 [1.180 1.209]^^

D4660 Acute bronchitis All subcodes 0.299 0.004 1.348 [1.338 1.358]#

D473 Chronic sinusitis All subcodes except 4739 0.214 0.001 1.239 [1.219 1.260]^^

D4739 Unspecified sinusitis (chronic) All subcodes 0.112 0.002 1.119 [1.107 1.131]^

D478 Other diseases of upper respiratory tract All subcodes except 4783 0.110 0.002 1.116 [1.103 1.128]^

D4783 Paralysis of vocal cords or larynx All subcodes 0.233 0.001 1.262 [1.242 1.281]^^

D481 Pneumococcal pneumonia [Streptococcus pneumoniae pneumonia] All subcodes 0.307 0.002 1.360 [1.342 1.379]#

All subcodes except 4820, 4821, 4822, 4824,

D482 Other bacterial pneumonia 4828, 48283 and 4829 0.276 0.000 1.318 [1.286 1.350]^^

D4820 Pneumonia due to Klebsiella pneumoniae All subcodes 0.407 0.001 1.502 [1.476 1.528]#

D4821 Pneumonia due to Pseudomonas All subcodes 0.532 0.002 1.702 [1.683 1.721]#

D4822 Pneumonia due to Hemophilus influenzae [H. influenzae] All subcodes 0.282 0.001 1.326 [1.297 1.355]^^

D4824 Pneumonia due to Staphylococcus All subcodes 0.481 0.005 1.618 [1.605 1.631]#

D4828 Pneumonia due to other specified bacteria All subcodes 0.400 0.001 1.492 [1.461 1.524]^^^

D48283 Pneumonia due to other gram-negative bacteria None 0.358 0.001 1.431 [1.410 1.453]#

D4829 Bacterial pneumonia, unspecified All subcodes 0.320 0.001 1.377 [1.349 1.406]^^^

D483 Pneumonia due to other specified organism All subcodes 0.477 0.000 1.611 [1.550 1.675]^^

D484 Pneumonia in infectious diseases classified elsewhere All subcodes 0.643 0.000 1.902 [1.837 1.969]^^^

D485 Bronchopneumonia, organism unspecified All subcodes 0.651 0.001 1.918 [1.892 1.945]#

D486 Pneumonia, organism unspecified All subcodes 0.391 0.067 1.478 [1.475 1.481]#

D487 Influenza All subcodes 0.339 0.001 1.404 [1.378 1.431]^^^

D490 Bronchitis, not specified as acute or chronic All subcodes 0.189 0.003 1.208 [1.198 1.219]#

D4912 Obstructive chronic bronchitis All subcodes 0.409 0.039 1.505 [1.501 1.509]#

D4920 Emphysematous bleb All subcodes 0.411 0.001 1.508 [1.478 1.537]#

D4928 Other emphysema All subcodes 0.107 0.013 1.113 [1.108 1.118]#

D493 Asthma All subcodes 0.136 0.036 1.146 [1.144 1.149]#

D494 Bronchiectasis All subcodes 0.242 0.002 1.274 [1.260 1.287]#

D496 Chronic airway obstruction, not elsewhere classified All subcodes 0.143 0.131 1.154 [1.153 1.156]#

D507 Pneumonitis due to solids and liquids All subcodes except 5070 0.321 0.000 1.379 [1.317 1.443]***

D5070 Pneumonitis due to inhalation of food or vomitus All subcodes 0.387 0.019 1.473 [1.467 1.479]#

D510 Empyema All subcodes except 5109 0.601 0.000 1.824 [1.761 1.889]^^^

D5109 Empyema without mention of fistula All subcodes 0.399 0.001 1.490 [1.465 1.516]#

D5118 Other specified forms of effusion, except tuberculous All subcodes 0.244 0.003 1.276 [1.263 1.288]#

D5119 Unspecified pleural effusion All subcodes 0.261 0.029 1.298 [1.293 1.302]#

D5121 Iatrogenic pneumothorax All subcodes * 0.196 0.004 1.217 [1.207 1.227]#

D5128 Other spontaneous pneumothorax All subcodes 0.370 0.003 1.448 [1.433 1.463]#

D513 Abscess of lung and mediastinum All subcodes 0.399 0.001 1.490 [1.458 1.522]^^^

D514 Pulmonary congestion and hypostasis All subcodes 0.127 0.002 1.135 [1.122 1.147]^^

D515 Postinflammatory pulmonary fibrosis All subcodes 0.154 0.010 1.166 [1.161 1.172]#

D5163 Idiopathic fibrosing alveolitis All subcodes 0.230 0.001 1.258 [1.237 1.278]^^

D5168 Other specified alveolar and parietoalveolar pneumonopathies All subcodes 0.418 0.001 1.519 [1.489 1.550]#

D517 Lung involvement in conditions classified elsewhere All subcodes 0.190 0.000 1.209 [1.183 1.236]^

All subcodes except 5180, 5183, 5184, 5185 and

D518 Other diseases of lung 5188 0.329 0.000 1.390 [1.350 1.431]^^

D5180 Pulmonary collapse All subcodes 0.176 0.024 1.193 [1.189 1.197]#

D5183 Pulmonary eosinophilia All subcodes 0.197 0.001 1.218 [1.199 1.236]^^

D5184 Acute edema of lung, unspecified All subcodes 0.129 0.001 1.138 [1.122 1.154]^

D5185 Pulmonary insufficiency following trauma and surgery All subcodes 0.334 0.008 1.397 [1.388 1.406]#

D5188 Other diseases of lung All subcodes 0.312 0.048 1.366 [1.362 1.370]#

D5190 Tracheostomy complications All subcodes * 0.204 0.001 1.226 [1.199 1.255]^

D5191 Other diseases of trachea and bronchus, not elsewhere classified All subcodes 0.201 0.001 1.223 [1.206 1.240]^^

D521 Diseases of hard tissues of teeth All subcodes 0.407 0.000 1.502 [1.455 1.551]^^

D527 Diseases of the salivary glands All subcodes 0.356 0.001 1.428 [1.398 1.458]^^^

D528 Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue All subcodes 0.430 0.001 1.538 [1.515 1.561]#

D530 Diseases of esophagus All subcodes except 5302, 5306 and 5308 0.056 0.022 1.058 [1.054 1.062]^^^

D5302 Ulcer of esophagus All subcodes 0.051 0.004 1.052 [1.044 1.060]***

D5306 Diverticulum of esophagus, acquired All subcodes 0.154 0.001 1.166 [1.146 1.186]^

D5308 Other specified disorders of esophagus All subcodes -0.009 0.090 0.991 [0.989 0.992]***

D531 Gastric ulcer All subcodes 0.007 0.014 1.007 [1.002 1.011]*

D532 Duodenal ulcer All subcodes except 53240 0.092 0.005 1.096 [1.088 1.104]^^



D53240 Chronic or unspecified duodenal ulcer with hemorrhage, without mention of obstruction None 0.049 0.004 1.050 [1.042 1.058]***

D53500 Acute gastritis, without mention of hemorrhage None 0.137 0.002 1.147 [1.135 1.159]^^

D53510 Atrophic gastritis, without mention of hemorrhage None 0.079 0.006 1.082 [1.075 1.089]^^

D53550 Unspecified gastritis and gastroduodenitis, without mention of hemorrhage None 0.075 0.012 1.078 [1.073 1.083]^^^

D536 Disorders of function of stomach All subcodes 0.181 0.010 1.199 [1.193 1.205]#

D5370 Acquired hypertrophic pyloric stenosis All subcodes 0.304 0.001 1.355 [1.337 1.373]#

D5400 Acute appendicitis with generalized peritonitis All subcodes 0.462 0.001 1.588 [1.560 1.615]#

D5401 Acute appendicitis with peritoneal abscess All subcodes 0.536 0.001 1.710 [1.676 1.744]#

Inguinal hernia, with obstruction, without mention of gangrene, unilateral or unspecified (not

D55010 specified as recurrent) All subcodes 0.209 0.001 1.232 [1.216 1.249]^^^

D551 Other hernia of abdominal cavity, with gangrene All subcodes 0.302 0.000 1.352 [1.304 1.402]^



D552 Other hernia of abdominal cavity, with obstruction, but without mention of gangrene All subcodes except 55220 and 55221 0.310 0.002 1.364 [1.350 1.378]#

D55220 Ventral, unspecified, hernia with obstruction None 0.341 0.001 1.406 [1.380 1.433]^^^

D55221 Incisional ventral hernia with obstruction None 0.274 0.002 1.315 [1.299 1.332]#

D555 Regional enteritis All subcodes 0.124 0.002 1.132 [1.120 1.144]^^

D556 Ulcerative colitis All subcodes except 5569 0.302 0.001 1.352 [1.330 1.375]^^^

D5569 Ulcerative colitis, unspecified All subcodes 0.171 0.001 1.187 [1.171 1.202]^^

D5570 Acute vascular insufficiency of intestine All subcodes 0.228 0.003 1.256 [1.244 1.268]#

D5571 Chronic vascular insufficiency of intestine All subcodes 0.367 0.001 1.444 [1.418 1.471]#

D5579 Unspecified vascular insufficiency of intestine All subcodes 0.182 0.003 1.200 [1.189 1.211]#

D558 Other and unspecified noninfectious gastroenteritis and colitis All subcodes 0.160 0.008 1.173 [1.167 1.180]#

All subcodes except 5601, 5602, 56039, 56081,

D560 Intestinal obstruction without mention of hernia 56089 and 5609 0.326 0.000 1.386 [1.345 1.428]^^

D5601 Paralytic ileus All subcodes 0.389 0.019 1.476 [1.470 1.482]#

D5602 Volvulus All subcodes 0.186 0.001 1.205 [1.187 1.222]^^

D56039 Other impaction of intestine None 0.302 0.004 1.352 [1.341 1.362]#

D56081 Intestinal or peritoneal adhesions with obstruction (postoperative) (postinfection) None 0.542 0.005 1.719 [1.705 1.734]#

D56089 Other specified intestinal obstruction None 0.327 0.003 1.387 [1.376 1.399]#

D5609 Unspecified intestinal obstruction All subcodes 0.335 0.009 1.398 [1.391 1.406]#

D56210 Diverticulosis of colon (without mention of hemorrhage) None 0.049 0.028 1.050 [1.047 1.054]^^^

D56211 Diverticulitis of colon (without mention of hemorrhage) None 0.298 0.009 1.347 [1.339 1.354]#

D56212 Diverticulosis of colon with hemorrhage None 0.036 0.010 1.037 [1.032 1.042]***









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al





Webtable 2C. RSILOS Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

D56213 Diverticulitis of colon with hemorrhage None 0.237 0.002 1.268 [1.253 1.284]#

D564 Functional digestive disorders, not elsewhere classified All subcodes except 5640 and 5648 0.054 0.005 1.055 [1.049 1.062]^

D5640 Constipation All subcodes 0.222 0.021 1.249 [1.245 1.253]#

D5648 Other specified functional disorders of intestine All subcodes 0.349 0.001 1.418 [1.391 1.446]^^^

D565 Anal fissure and fistula All subcodes 0.149 0.000 1.161 [1.133 1.189]***

D566 Abscess of anal and rectal regions All subcodes 0.458 0.000 1.581 [1.545 1.618]#

D567 Peritonitis and retroperitoneal infections All subcodes 0.287 0.005 1.333 [1.323 1.344]#

D5688 Other specified disorders of peritoneum All subcodes 0.309 0.001 1.362 [1.341 1.384]#

D5691 Rectal prolapse All subcodes 0.325 0.001 1.384 [1.357 1.411]^^^

D5695 Abscess of intestine All subcodes 0.246 0.001 1.279 [1.261 1.298]^^^

D5696 Colostomy and enterostomy complications All subcodes * 0.293 0.002 1.341 [1.320 1.361]#

D5698 Other specified disorders of intestine All subcodes 0.110 0.009 1.116 [1.110 1.122]#

D570 Acute and subacute necrosis of liver All subcodes 0.242 0.001 1.274 [1.252 1.296]^^

D5715 Cirrhosis of liver without mention of alcohol All subcodes 0.091 0.006 1.095 [1.087 1.102]^^

D572 Liver abscess and sequelae of chronic liver disease All subcodes except 5722 0.221 0.003 1.247 [1.235 1.259]#

D5722 Hepatic encephalopathy All subcodes 0.353 0.002 1.424 [1.407 1.442]#

D573 Other disorders of liver All subcodes except 5733 and 5738 0.160 0.001 1.173 [1.153 1.192]^

D5733 Hepatitis, unspecified All subcodes 0.191 0.001 1.211 [1.194 1.229]^^

D5738 Other specified disorders of liver All subcodes 0.114 0.001 1.121 [1.107 1.135]^

D574 Cholelithiasis All subcodes except 57400 and 57470 0.108 0.023 1.114 [1.109 1.119]#

D57400 Calculus of gallbladder with acute cholecystitis, without mention of obstruction None 0.239 0.007 1.270 [1.261 1.279]#



D57470 Calculus of gallbladder and bile duct with other cholecystitis, without mention of obstruction None 0.201 0.001 1.223 [1.201 1.246]^

D5748 Calculus of gallbladder and bile duct with acute and chronic cholecystitis All subcodes 0.266 0.001 1.305 [1.281 1.328]^^

D5750 Acute cholecystitis All subcodes 0.315 0.002 1.370 [1.356 1.385]#

D57511 Chronic cholecystitis None 0.150 0.002 1.162 [1.146 1.177]^^

D57512 Acute and chronic cholecystitis None 0.318 0.001 1.375 [1.348 1.402]^^^

D5761 Cholangitis All subcodes 0.160 0.002 1.174 [1.161 1.186]^^

D5762 Obstruction of bile duct All subcodes 0.102 0.002 1.107 [1.094 1.120]^

D5768 Other specified disorders of biliary tract All subcodes 0.186 0.002 1.204 [1.191 1.218]^^^

D577 Diseases of pancreas All subcodes except 5770, 5771 and 5772 0.158 0.001 1.171 [1.153 1.188]^

D5770 Acute pancreatitis All subcodes 0.464 0.009 1.590 [1.581 1.599]#

D5771 Chronic pancreatitis All subcodes 0.241 0.001 1.272 [1.254 1.289]^^^

D5772 Cyst and pseudocyst of pancreas All subcodes 0.438 0.001 1.550 [1.522 1.578]#

D580 Acute glomerulonephritis All subcodes 0.341 0.000 1.406 [1.369 1.444]^^

D581 Nephrotic syndrome All subcodes except 58181 0.242 0.001 1.274 [1.249 1.301]^^

D58181 Nephrotic syndrome in diseases classified elsewhere None 0.243 0.001 1.275 [1.250 1.301]^^

D584 Acute renal failure All subcodes except 5845 and 5849 0.401 0.000 1.493 [1.459 1.528]^^^

D5845 Acute kidney failure with lesion of tubular necrosis All subcodes 0.430 0.005 1.537 [1.526 1.548]#

D5849 Acute renal failure, unspecified All subcodes 0.351 0.044 1.421 [1.418 1.425]#

D585 Chronic kidney disease All subcodes 0.092 0.031 1.096 [1.092 1.099]#

D586 Renal failure, unspecified All subcodes 0.159 0.003 1.172 [1.161 1.183]^^^

D590 Infections of kidney All subcodes except 59010 and 59080 0.341 0.000 1.407 [1.371 1.445]^^

D59010 Acute pyelonephritis without lesion of renal medullary necrosis None 0.296 0.001 1.345 [1.327 1.363]#

D59080 Pyelonephritis, unspecified None 0.241 0.002 1.273 [1.258 1.288]#

D591 Hydronephrosis All subcodes 0.230 0.010 1.258 [1.251 1.266]#

D5921 Calculus of ureter All subcodes -0.179 0.004 0.836 [0.828 0.843]#

D5932 Cyst of kidney, acquired All subcodes 0.128 0.001 1.137 [1.122 1.152]^

D5938 Other specified disorders of kidney and ureter All subcodes 0.160 0.001 1.174 [1.156 1.192]^

D5939 Unspecified disorder of kidney and ureter All subcodes 0.103 0.041 1.109 [1.107 1.112]#

D594 Calculus of lower urinary tract All subcodes -0.088 0.002 0.916 [0.903 0.928]***

D5950 Acute cystitis All subcodes 0.254 0.001 1.289 [1.267 1.311]^^

D5959 Cystitis, unspecified All subcodes 0.248 0.002 1.281 [1.266 1.296]#

D5961 Intestinovesical fistula All subcodes 0.196 0.001 1.216 [1.190 1.242]^

D59654 Neurogenic bladder, not otherwise specified None 0.161 0.002 1.175 [1.164 1.187]^^^

D5990 Urinary tract infection, site not specified All subcodes 0.324 0.099 1.382 [1.379 1.384]#

D5996 Urinary obstruction All subcodes 0.203 0.002 1.225 [1.213 1.237]#

D5997 Hematuria All subcodes 0.274 0.020 1.315 [1.310 1.320]#

D605 Redundant prepuce and phimosis All subcodes 0.240 0.000 1.271 [1.243 1.299]^^

D608 Other disorders of male genital organs All subcodes 0.407 0.001 1.503 [1.477 1.530]#

D611 Other disorders of breast All subcodes 0.149 0.001 1.161 [1.147 1.176]^^



D614 Inflammatory disease of ovary, fallopian tube, pelvic cellular tissue, and peritoneum All subcodes except 6146 0.269 0.001 1.309 [1.282 1.336]^^

D6146 Pelvic peritoneal adhesions, female (postoperative) (postinfection) All subcodes -0.094 0.002 0.910 [0.898 0.922]***

D6180 Prolapse of vaginal walls without mention of uterine prolapse All subcodes -0.178 0.004 0.837 [0.830 0.844]#

D6185 Prolapse of vaginal vault after hysterectomy All subcodes -0.195 0.003 0.823 [0.814 0.832]^^^

D619 Fistula involving female genital tract All subcodes 0.337 0.001 1.401 [1.372 1.431]^^^

D623 Noninflammatory disorders of vagina All subcodes 0.215 0.001 1.240 [1.218 1.262]^^

D681 Cellulitis and abscess of finger and toe All subcodes except 68110 0.186 0.001 1.205 [1.182 1.228]^

D68110 Cellulitis and abscess of toe, unspecified None 0.188 0.002 1.207 [1.194 1.221]^^^

All subcodes except 6820, 6822, 6823, 6824,

D682 Other cellulitis and abscess 6826, 6827 and 6829 0.270 0.001 1.310 [1.292 1.328]#

D6820 Cellulitis and abscess of face All subcodes 0.349 0.000 1.417 [1.385 1.449]^^^

D6822 Cellulitis and abscess of trunk All subcodes 0.275 0.004 1.317 [1.306 1.327]#

D6823 Cellulitis and abscess of upper arm and forearm All subcodes 0.353 0.003 1.424 [1.412 1.437]#

D6824 Cellulitis and abscess of hand, except fingers and thumb All subcodes 0.365 0.001 1.440 [1.417 1.465]#

D6826 Cellulitis and abscess of leg, except foot All subcodes 0.410 0.015 1.507 [1.501 1.513]#

D6827 Cellulitis and abscess of foot, except toes All subcodes 0.330 0.006 1.391 [1.381 1.400]#

D6829 Cellulitis and abscess of unspecified sites All subcodes 0.321 0.001 1.379 [1.359 1.400]#

D686 Other local infections of skin and subcutaneous tissue All subcodes 0.196 0.001 1.217 [1.196 1.237]^^

D692 Contact dermatitis and other eczema All subcodes 0.233 0.001 1.263 [1.247 1.279]^^^

D6930 Dermatitis due to drugs and medicines taken internally All subcodes 0.369 0.001 1.447 [1.428 1.466]#

D694 Bullous dermatoses All subcodes 0.250 0.000 1.284 [1.255 1.315]^

D695 Erythematous conditions All subcodes 0.143 0.001 1.154 [1.137 1.172]^

D703 Diseases of nail All subcodes 0.248 0.001 1.281 [1.261 1.301]^^^

D707 Chronic ulcer of skin All subcodes except 7070, 7071 and 7078 0.486 0.000 1.626 [1.568 1.686]^^

D7070 Chronic ulcer of skin All subcodes 0.401 0.026 1.494 [1.489 1.499]#

D7071 Ulcer of lower limbs, except pressure ulcer All subcodes 0.226 0.021 1.253 [1.248 1.258]#

D7078 Chronic ulcer of other specified sites All subcodes 0.283 0.001 1.327 [1.307 1.347]^^^

D710 Diffuse diseases of connective tissue All subcodes except 7100 0.103 0.002 1.108 [1.097 1.120]^

D7100 Systemic lupus erythematosus All subcodes 0.110 0.003 1.116 [1.105 1.127]^^

D7110 Pyogenic arthritis All subcodes except 71106 0.329 0.001 1.389 [1.366 1.412]#

D71106 Pyogenic arthritis, lower leg None 0.419 0.001 1.520 [1.496 1.543]#

D7140 Rheumatoid arthritis All subcodes 0.065 0.014 1.067 [1.062 1.071]^^^

D71516 Osteoarthrosis, localized, primary, lower leg None 0.070 0.004 1.073 [1.064 1.082]^

D71536 Osteoarthrosis, localized, not specified whether primary or secondary, lower leg None 0.055 0.027 1.057 [1.052 1.062]^^

Osteoarthrosis involving, or with mention of more than one site, but not specified as generalized,

D71589 multiple sites None 0.095 0.004 1.100 [1.092 1.109]^^

D71590 Osteoarthrosis, unspecified whether generalized or localized, site unspecified None 0.052 0.048 1.053 [1.051 1.056]#

D71596 Osteoarthrosis, unspecified whether generalized or localized, lower leg None 0.101 0.017 1.106 [1.100 1.112]#

D71598 Osteoarthrosis, unspecified whether generalized or localized, other specified sites None 0.117 0.002 1.124 [1.110 1.137]^

D71690 Arthropathy, unspecified, site unspecified None -0.050 0.014 0.951 [0.947 0.955]^^

D71906 Effusion of joint, lower leg None 0.120 0.001 1.127 [1.111 1.144]^

D7194 Pain in joint All subcodes except 71945 0.053 0.007 1.054 [1.048 1.060]^

D71945 Pain in joint, pelvic region and thigh None 0.097 0.007 1.102 [1.096 1.109]^^^

D7197 Difficulty in walking All subcodes 0.179 0.002 1.196 [1.182 1.209]^^^

D721 Spondylosis and allied disorders All subcodes except 7211 and 7213 0.070 0.006 1.073 [1.067 1.080]^^

D7211 Cervical spondylosis with myelopathy All subcodes 0.383 0.002 1.467 [1.448 1.487]#









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al





Webtable 2C. RSILOS Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

D7213 Lumbosacral spondylosis without myelopathy All subcodes 0.116 0.007 1.123 [1.116 1.130]#



D722 Intervertebral disc disorders All subcodes except 72252, 72271 and 72293 0.070 0.011 1.073 [1.067 1.079]^^

D72252 Degeneration of lumbar or lumbosacral intervertebral disc None 0.098 0.005 1.103 [1.096 1.111]^^

D72271 Intervertebral disc disorder with myelopathy, cervical region None 0.372 0.001 1.451 [1.422 1.481]^^^

D72293 Other and unspecified disc disorder, lumbar region None 0.267 0.001 1.306 [1.286 1.327]^^^

D723 Other disorders of cervical region All subcodes 0.123 0.003 1.131 [1.121 1.141]^^

All subcodes except 72400, 72402, 7242, 7243

D724 Other and unspecified disorders of back and 7245 0.125 0.003 1.133 [1.123 1.143]^^

D72400 Spinal stenosis, unspecified region None 0.055 0.003 1.057 [1.047 1.066]***

D72402 Spinal stenosis, lumbar region None 0.090 0.014 1.094 [1.088 1.099]^^^

D7242 Lumbago All subcodes 0.153 0.007 1.165 [1.159 1.172]#

D7243 Sciatica All subcodes 0.135 0.001 1.145 [1.127 1.162]^

D7245 Backache, unspecified All subcodes 0.167 0.006 1.182 [1.175 1.189]#

D725 Polymyalgia rheumatica All subcodes 0.049 0.004 1.050 [1.041 1.058]***

D726 Peripheral enthesopathies and allied syndromes All subcodes 0.070 0.005 1.072 [1.064 1.080]^

D7274 Ganglion and cyst of synovium, tendon, and bursa All subcodes -0.213 0.001 0.808 [0.795 0.822]^^

D728 Disorders of muscle, ligament, and fascia All subcodes except 7288 0.286 0.001 1.331 [1.315 1.348]#

D7288 Other disorders of muscle, ligament, and fascia All subcodes 0.238 0.004 1.269 [1.259 1.278]#

D729 Other disorders of soft tissues All subcodes except 7291, 7295 and 72989 0.060 0.006 1.062 [1.055 1.069]^

D7295 Pain in limb All subcodes 0.129 0.006 1.138 [1.131 1.146]#

D72989 Other musculoskeletal symptoms referable to limbs None 0.059 0.004 1.061 [1.053 1.070]***

D7300 Acute osteomyelitis All subcodes except 73007 0.481 0.001 1.618 [1.587 1.650]#

D73007 Acute osteomyelitis, ankle and foot None 0.227 0.001 1.255 [1.239 1.272]^^^

D73017 Chronic osteomyelitis, ankle and foot None 0.196 0.001 1.216 [1.195 1.237]^^

D7302 Unspecified osteomyelitis All subcodes except 73027 and 73028 0.444 0.001 1.559 [1.535 1.583]#

D73027 Unspecified osteomyelitis, ankle and foot None 0.311 0.003 1.365 [1.352 1.378]#

D73028 Unspecified osteomyelitis, other specified sites None 0.591 0.001 1.806 [1.773 1.840]#

D73300 Osteoporosis, unspecified None 0.041 0.045 1.042 [1.040 1.045]^^^

D7331 Pathologic fracture All subcodes except 73313 and 73314 0.307 0.001 1.360 [1.342 1.378]#

D73313 Pathologic fracture of vertebrae None 0.324 0.008 1.382 [1.374 1.390]#

D73314 Pathologic fracture of neck of femur None 0.253 0.001 1.288 [1.267 1.308]^^^

D7334 Aseptic necrosis of bone All subcodes 0.084 0.002 1.088 [1.077 1.099]^

D73679 Other acquired deformities of ankle and foot None 0.166 0.001 1.180 [1.163 1.198]^^

D780 General symptoms All subcodes except 78009 and 78039 0.098 0.088 1.103 [1.101 1.105]#

D78009 Other alteration of consciousness None 0.137 0.006 1.147 [1.140 1.155]#

D78039 Other convulsions None 0.163 0.027 1.177 [1.174 1.181]#

D7812 Abnormality of gait All subcodes 0.210 0.008 1.234 [1.227 1.241]#

D7813 Lack of coordination All subcodes 0.131 0.002 1.140 [1.128 1.151]^^

D7821 Rash and other nonspecific skin eruption All subcodes 0.281 0.001 1.325 [1.308 1.342]#

D7823 Edema All subcodes 0.148 0.005 1.159 [1.152 1.167]#

D7824 Jaundice, unspecified, not of newborn All subcodes 0.179 0.002 1.196 [1.182 1.211]^^

D783 Symptoms concerning nutrition, metabolism, and development All subcodes 0.143 0.010 1.154 [1.148 1.159]#

D7843 Aphasia All subcodes 0.148 0.004 1.160 [1.150 1.169]^^^

D7845 Other speech disturbance All subcodes 0.093 0.004 1.098 [1.089 1.107]^^

D7847 Epistaxis All subcodes 0.153 0.003 1.165 [1.155 1.175]^^^

D7854 Gangrene All subcodes 0.279 0.007 1.322 [1.313 1.331]#

D7855 Shock without mention of trauma All subcodes 0.092 0.008 1.096 [1.089 1.103]^^

D7860 Enlargement of lymph nodes All subcodes 0.062 0.032 1.064 [1.061 1.067]#

D7863 Hemoptysis All subcodes 0.154 0.005 1.166 [1.158 1.175]#

D78659 Other chest pain None -0.088 0.018 0.916 [0.912 0.919]#

D7870 Nausea and vomiting All subcodes 0.091 0.017 1.095 [1.091 1.100]#

D7872 Dysphagia All subcodes 0.196 0.015 1.217 [1.212 1.222]#

D7876 Incontinence of feces All subcodes 0.182 0.001 1.200 [1.180 1.220]^^

D78791 Diarrhea None 0.237 0.011 1.268 [1.262 1.274]#

D78820 Retention of urine, unspecified None 0.240 0.020 1.271 [1.267 1.276]#

D78829 Other specified retention of urine None 0.226 0.004 1.253 [1.243 1.263]#

D7883 Urinary incontinence All subcodes 0.090 0.009 1.094 [1.088 1.099]^^^

D7889 Other symptoms involving urinary system All subcodes 0.147 0.002 1.158 [1.146 1.170]^^

All subcodes except 78900, 78904, 78907 and

D789 Other symptoms involving abdomen and pelvis 78909 0.097 0.020 1.102 [1.098 1.106]#

D78900 Abdominal pain, unspecified site None 0.143 0.017 1.154 [1.149 1.158]#

D78904 Abdominal pain, left lower quadrant None 0.120 0.001 1.127 [1.112 1.142]^

D78907 Abdominal pain, generalized None 0.129 0.001 1.138 [1.121 1.156]^

D78909 Abdominal pain, other specified site None 0.092 0.004 1.096 [1.088 1.104]^^

D7906 Other abnormal blood chemistry All subcodes 0.064 0.007 1.066 [1.060 1.073]^

D7907 Bacteremia All subcodes 0.369 0.007 1.447 [1.438 1.456]#

D7909 Other nonspecific findings on examination of blood All subcodes 0.075 0.006 1.078 [1.071 1.085]^^



D794 Nonspecific abnormal results of function studies All subcodes except 79431, 79439 and 7948 -0.278 0.001 0.757 [0.746 0.768]^^^

D79431 Nonspecific abnormal electrocardiogram [ECG] [EKG] None -0.100 0.002 0.905 [0.896 0.914]^

D79439 Other nonspecific abnormal results of function study of cardiovascular system None -0.408 0.003 0.665 [0.659 0.671]#

D7948 Nonspecific abnormal results of function study of liver All subcodes 0.119 0.002 1.126 [1.114 1.138]^^



D795 Other and nonspecific abnormal cytological, histological, immunological and DNA test findings All subcodes 0.258 0.001 1.294 [1.269 1.319]^^

D799 Other ill-defined and unknown causes of morbidity and mortality All subcodes 0.208 0.017 1.231 [1.226 1.236]#

D800 Fracture of vault of skull 0.513 0.000 1.670 [1.578 1.767]^

D802 Fracture of face bones All subcodes 0.376 0.001 1.456 [1.434 1.478]#

D8050 Cervical closed fracture of vertebral column without mention of spinal cord injury All subcodes 0.533 0.001 1.704 [1.673 1.736]#

D8052 Closed fracture of dorsal [thoracic] vertebra without mention of spinal cord injury All subcodes 0.289 0.002 1.335 [1.320 1.351]#

D8054 Closed fracture of lumbar vertebra without mention of spinal cord injury All subcodes 0.362 0.003 1.436 [1.422 1.450]#

D806 Fracture of vertebral column with spinal cord injury All subcodes 0.693 0.000 1.999 [1.930 2.071]#

D8070 Fracture of rib(s), closed All subcodes 0.321 0.003 1.379 [1.365 1.393]#

D808 Fracture of pelvis All subcodes except 8082 0.489 0.001 1.630 [1.606 1.654]#

D8082 Closed fracture of pubis All subcodes 0.339 0.002 1.404 [1.388 1.420]#

D810 Fracture of clavicle All subcodes 0.223 0.000 1.250 [1.223 1.278]^

D81200 Closed fracture of unspecified part of upper end of humerus None 0.289 0.001 1.335 [1.315 1.354]#

D81201 Closed fracture of surgical neck of humerus None 0.297 0.001 1.346 [1.327 1.365]#

D81209 Other closed fracture of upper end of humerus None 0.344 0.001 1.411 [1.388 1.433]#

D8122 Fracture of humerus shaft or unspecified part, closed All subcodes 0.308 0.001 1.361 [1.339 1.383]#

D8124 Fracture of humerus, lower end, closed All subcodes 0.337 0.001 1.401 [1.374 1.428]^^^

D8134 Fracture of radius and ulna, lower end, closed All subcodes 0.067 0.003 1.069 [1.058 1.080]***

All subcodes except 82003, 82009, 82020, 82021,

D820 Fracture of neck of femur 82022 and 8208 0.171 0.001 1.186 [1.170 1.202]^^

D82003 Closed fracture of base of neck of femur None 0.179 0.001 1.196 [1.177 1.214]^^

D82009 Other closed transcervical fracture of neck of femur None 0.160 0.010 1.173 [1.165 1.180]#

D82020 Closed fracture of trochanteric section of neck of femur None 0.191 0.001 1.211 [1.192 1.231]^^

D82021 Closed fracture of intertrochanteric section of neck of femur None 0.213 0.017 1.238 [1.230 1.246]#

D82022 Closed fracture of subtrochanteric section of neck of femur None 0.202 0.002 1.224 [1.210 1.238]^^^

D8208 Closed fracture of unspecified part of neck of femur All subcodes 0.160 0.016 1.174 [1.168 1.180]#

D82100 Closed fracture of unspecified part of femur None 0.167 0.001 1.182 [1.166 1.198]^^

D82101 Closed fracture of shaft of femur None 0.262 0.001 1.300 [1.281 1.320]^^^

D8212 Fracture of other and unspecified parts of femur, lower end, closed All subcodes except 82123 0.277 0.001 1.319 [1.298 1.340]^^^

D82123 Closed supracondylar fracture of femur None 0.310 0.001 1.364 [1.343 1.386]#

D8220 Closed fracture of patella All subcodes 0.170 0.001 1.185 [1.165 1.206]^

D82300 Closed fracture of upper end of tibia alone None 0.380 0.001 1.463 [1.437 1.490]#

D8238 Fracture of tibia and fibula, Unspecified part, closed All subcodes 0.378 0.001 1.459 [1.428 1.491]^^^

D824 Fracture of ankle All subcodes except 8248 0.110 0.003 1.116 [1.103 1.130]^









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al





Webtable 2C. RSILOS Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

D8248 Unspecified fracture of ankle, closed All subcodes 0.137 0.001 1.147 [1.132 1.164]^

D825 Fracture of one or more tarsal and metatarsal bones All subcodes 0.307 0.001 1.359 [1.330 1.388]^^

D831 Dislocation of shoulder All subcodes 0.293 0.000 1.340 [1.300 1.381]^

D836 Dislocation of knee All subcodes 0.222 0.000 1.248 [1.214 1.283]^

D839 Other, multiple, and ill-defined dislocations All subcodes 0.536 0.000 1.710 [1.642 1.780]^^

D844 Sprains and strains of knee and leg All subcodes 0.181 0.000 1.198 [1.170 1.227]***

D851 Cerebral laceration and contusion All subcodes 0.403 0.001 1.497 [1.468 1.527]#



D8520 Subarachnoid hemorrhage following injury without mention of open intracranial wound All subcodes 0.415 0.001 1.515 [1.484 1.546]#

Subdural hemorrhage following injury without mention of open intracranial wound, unspecified

D85220 state of consciousness None 0.355 0.001 1.426 [1.401 1.452]#

D853 Other and unspecified intracranial hemorrhage following injury All subcodes 0.391 0.000 1.479 [1.446 1.514]^^^

D854 Intracranial injury of other and unspecified nature All subcodes 0.285 0.000 1.330 [1.285 1.376]^

D860 Traumatic pneumothorax and hemothorax All subcodes except 8600 0.292 0.001 1.339 [1.310 1.369]^^

D8600 Traumatic pneumothorax without mention of open wound into thorax All subcodes 0.253 0.001 1.288 [1.261 1.317]^^

D861 Injury to heart and lung All subcodes 0.324 0.000 1.383 [1.350 1.416]^^

D8670 Injury to bladder and urethra, without mention of open wound into cavity All subcodes 0.208 0.001 1.231 [1.215 1.248]^^^

D879 Open wound of other and unspecified sites, except limbs All subcodes 0.662 0.000 1.939 [1.869 2.011]^^^

D892 Open wound of foot except toe(s) alone All subcodes 0.277 0.000 1.319 [1.277 1.362]^

D905 Late effects of musculoskeletal and connective tissue injuries All subcodes 0.237 0.002 1.267 [1.251 1.283]#

D909 Late effects of other and unspecified external causes All subcodes 0.147 0.001 1.158 [1.139 1.177]^

D922 Contusion of trunk All subcodes 0.206 0.002 1.229 [1.214 1.245]^^^

D92401 Contusion of hip None 0.222 0.001 1.248 [1.228 1.268]^^

D9241 Contusion of lower limb and of knee and lower leg All subcodes 0.169 0.001 1.184 [1.167 1.201]^^

D942 Burn of trunk All subcodes 0.804 0.000 2.234 [2.156 2.315]#

D952 Spinal cord injury without evidence of spinal bone injury All subcodes 0.723 0.000 2.060 [1.984 2.139]#

D995 Certain adverse effects not elsewhere classified All subcodes 0.059 0.012 1.061 [1.055 1.066]^^

All subcodes except 9964, 9965, 9966, 99673,

D996 Complications peculiar to certain specified procedures 99674, 99676, 99677 and 9968 * 0.076 0.012 1.079 [1.075 1.084]^^^

D9964 Mechanical complication of internal orthopedic device, implant, and graft All subcodes * 0.199 0.009 1.220 [1.212 1.228]#

D9965 Mechanical complication of other specified prosthetic device, implant, and graft All subcodes * 0.218 0.001 1.244 [1.226 1.262]^^



D9966 Infection and inflammatory reaction due to internal prosthetic device, implant, and graft All subcodes * 0.366 0.014 1.442 [1.435 1.448]#

D99673 Other complications due to renal dialysis device, implant, and graft None * -0.128 0.005 0.880 [0.873 0.887]^^^

D99674 Other complications due to other vascular device, implant, and graft None * 0.193 0.005 1.213 [1.204 1.222]#

D99676 Other complications due to genitourinary device, implant, and graft None * 0.180 0.001 1.197 [1.179 1.215]^^

D99677 Other complications due to internal joint prosthesis None * 0.167 0.001 1.182 [1.165 1.199]^^

D9968 Complications of transplanted organ All subcodes * 0.206 0.001 1.229 [1.208 1.250]^^

All subcodes except 9970, 99702, 99762 and

D997 Complications affecting specified body systems, not elsewhere classified 99769 * 0.181 0.035 1.198 [1.195 1.202]#

D9970 Nervous system complications All subcodes except 99702 * 0.454 0.001 1.575 [1.547 1.603]#

D99702 Iatrogenic cerebrovascular infarction or hemorrhage None * 0.450 0.001 1.569 [1.548 1.591]#

D99762 Infection (chronic) of amputation stump None * 0.399 0.001 1.491 [1.469 1.513]#

D99769 Other amputation stump complication None * 0.213 0.001 1.238 [1.216 1.260]^^



All subcodes except 99811, 99812, 99813, 9982,

D998 Other complications of procedures, not elsewhere classified 9983, 99859, 9986, 99883 and 99889 * 0.268 0.001 1.308 [1.290 1.327]#

D99811 Hemorrhage complicating a procedure None * 0.150 0.008 1.162 [1.155 1.168]#

D99812 Hematoma complicating a procedure None * 0.374 0.009 1.453 [1.445 1.461]#

D99813 Seroma complicating a procedure None * 0.269 0.001 1.309 [1.283 1.334]^^

D9982 Accidental puncture or laceration during a procedure, not elsewhere classified All subcodes * 0.194 0.006 1.214 [1.206 1.223]#

D9983 Disruption of wound All subcodes * 0.471 0.003 1.602 [1.586 1.617]#

D99859 Other postoperative infection None * 0.425 0.009 1.529 [1.521 1.538]#

D9986 Persistent postoperative fistula All subcodes * 0.589 0.001 1.803 [1.770 1.836]#

D99883 Non-healing surgical wound None * 0.409 0.001 1.506 [1.484 1.529]#

D99889 Other specified complications of procedures not elsewhere classified None * 0.191 0.004 1.211 [1.202 1.220]#

D9992 Other vascular complications of medical care, not elsewhere classified All subcodes * 0.353 0.001 1.423 [1.400 1.447]#

D9993 Other infection All subcodes * 0.298 0.001 1.347 [1.320 1.375]^^

DE8497 Accidents occurring in residential institution All subcodes 0.067 0.007 1.069 [1.063 1.076]^^

DE888 Other and unspecified fall All subcodes 0.093 0.005 1.097 [1.089 1.105]^^

DE93 Antibiotics All subcodes 0.083 0.005 1.087 [1.080 1.095]^^

DE942 Agents primarily affecting the cardiovascular system All subcodes 0.161 0.001 1.175 [1.156 1.194]^

DV02 Carrier or suspected carrier of infectious diseases All subcodes 0.142 0.001 1.153 [1.133 1.173]^

DV09 Infection with drug-resistant microorganisms All subcodes except V090 0.424 0.001 1.528 [1.495 1.561]#

DV090 Infection with microorganisms resistant to penicillins All subcodes 0.216 0.008 1.241 [1.233 1.250]#

DV1005 Personal history of malignant neoplasm of large intestine None 0.049 0.014 1.050 [1.045 1.054]^^

DV103 Personal history of malignant neoplasm of breast All subcodes 0.045 0.020 1.046 [1.042 1.049]^^

DV1259 Personal history of other diseases of circulatory system None 0.025 0.033 1.025 [1.022 1.028]^

DV1272 Personal history of colonic polyps None -0.088 0.003 0.916 [0.908 0.923]^

DV13 Personal history of other diseases All subcodes -0.110 0.003 0.896 [0.888 0.905]^^

DV140 Personal history of allergy to penicillin All subcodes -0.050 0.005 0.951 [0.944 0.957]***

DV15 Other personal history presenting hazards to health All subcodes -0.071 0.054 0.931 [0.929 0.933]#

DV17 Family history of certain chronic disabling diseases All subcodes except V173 -0.135 0.002 0.874 [0.864 0.884]^^

DV173 Family history of ischemic heart disease All subcodes -0.191 0.006 0.826 [0.821 0.832]#

DV422 Heart valve replaced by transplant All subcodes 0.078 0.003 1.081 [1.071 1.091]^

DV433 Heart valve replaced by other means All subcodes 0.240 0.011 1.271 [1.265 1.277]#

DV4364 Hip joint replacement None 0.051 0.014 1.052 [1.048 1.056]^^

DV44 Artificial opening status All subcodes 0.155 0.009 1.168 [1.162 1.174]#

DV4501 Cardiac pacemaker in situ None 0.050 0.027 1.051 [1.048 1.054]^^^

DV46 Encounter for dialysis and dialysis catheter care All subcodes 0.184 0.004 1.202 [1.192 1.212]#

DV4975 Below knee amputation status None 0.209 0.003 1.233 [1.221 1.244]#

DV4976 Above knee amputation status None 0.211 0.002 1.235 [1.221 1.249]^^^

DV5331 Fitting and adjustment of cardiac pacemaker None -0.489 0.001 0.613 [0.604 0.622]#

DV54 Other orthopedic aftercare All subcodes 0.357 0.005 1.429 [1.418 1.439]#

DV55 Attention to artificial openings All subcodes 0.611 0.003 1.842 [1.820 1.865]#

DV56 Encounter for dialysis and dialysis catheter care All subcodes -0.182 0.000 0.834 [0.815 0.853]^

DV57 Care involving use of rehabilitation procedures All subcodes except V571 and V5789 0.369 0.002 1.447 [1.427 1.467]#

DV571 Care involving other physical therapy All subcodes 0.837 0.003 2.310 [2.285 2.335]#

DV5789 Care involving other specified rehabilitation procedure None 1.042 0.021 2.835 [2.822 2.848]#

DV63 Unavailability of other medical facilities for care All subcodes 1.056 0.000 2.876 [2.766 2.990]#

DV644 Closed surgical procedure converted to open procedure All subcodes 0.111 0.003 1.117 [1.105 1.128]^^

DV66 Convalescence and palliative care All subcodes 0.166 0.001 1.181 [1.160 1.203]^

DV72 Special investigations and examinations All subcodes -0.201 0.001 0.818 [0.806 0.830]^^

P0013 Injection or infusion of nesiritide None 0.235 0.001 1.265 [1.247 1.283]^^^

P0040 Procedure on single vessel None -0.214 0.009 0.807 [0.802 0.811]#

P0041 Procedure on two vessels None -0.186 0.002 0.830 [0.821 0.839]^^^

P011 Diagnostic procedures on skull, brain, and cerebral meninges All subcodes 0.464 0.000 1.591 [1.553 1.631]#

P012 Craniotomy and craniectomy All subcodes 0.481 0.000 1.617 [1.575 1.660]^^^

P0131 Incision of cerebral meninges None 0.762 0.002 2.142 [2.114 2.171]#

P0159 Other excision or destruction of lesion or tissue of brain None 0.721 0.001 2.056 [2.024 2.089]#

P022 Ventriculostomy All subcodes 0.457 0.001 1.580 [1.544 1.617]#

P0309 Other exploration and decompression of spinal canal None 0.049 0.011 1.050 [1.044 1.056]^

P0331 Spinal tap None 0.442 0.007 1.556 [1.546 1.565]#

P0359 Other repair and plastic operations on spinal cord structures None 0.222 0.001 1.249 [1.229 1.269]^^



P0390 Insertion of catheter into spinal canal for infusion of therapeutic or palliative substances None 0.146 0.004 1.157 [1.149 1.166]#

P0391 Injection of anesthetic into spinal canal for analgesia None 0.102 0.004 1.107 [1.097 1.117]^^

P0392 Injection of other agent into spinal canal None 0.408 0.004 1.504 [1.488 1.519]#









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al





Webtable 2C. RSILOS Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

P062 Unilateral thyroid lobectomy All subcodes -0.428 0.001 0.652 [0.641 0.663]#

P0689 Other parathyroidectomy None -0.403 0.001 0.668 [0.655 0.682]#

P088 Other repair of eyelid All subcodes 0.168 0.000 1.183 [1.154 1.212]***

P311 Temporary tracheostomy All subcodes 0.911 0.005 2.487 [2.462 2.513]#

P3129 Other permanent tracheostomy None 0.876 0.001 2.401 [2.348 2.455]#

P3142 Laryngoscopy and other tracheoscopy None 0.318 0.002 1.375 [1.361 1.389]#

P3229 Other local excision or destruction of lesion or tissue of lung None 0.388 0.002 1.474 [1.457 1.491]#

P324 Lobectomy of lung All subcodes 0.751 0.003 2.120 [2.097 2.143]#

P3322 Fiber-optic bronchoscopy None 0.310 0.004 1.363 [1.352 1.375]#

P3323 Other bronchoscopy None 0.296 0.002 1.344 [1.329 1.358]#

P3324 Closed [endoscopic] biopsy of bronchus None 0.428 0.011 1.534 [1.527 1.542]#

P3326 Closed [percutaneous] [needle] biopsy of lung None 0.404 0.003 1.498 [1.484 1.512]#

P3327 Closed endoscopic biopsy of lung None 0.357 0.004 1.429 [1.417 1.441]#

P3328 Open biopsy of lung None 0.370 0.001 1.448 [1.427 1.470]#

P3403 Reopening of recent thoracotomy site None 0.186 0.001 1.204 [1.180 1.228]^

P3404 Insertion of intercostal catheter for drainage None 0.395 0.008 1.485 [1.475 1.495]#

P3409 Other incision of pleura None 0.372 0.002 1.451 [1.434 1.469]#

P3424 Other pleural biopsy None 0.226 0.001 1.253 [1.234 1.272]^^

P3451 Decortication of lung None 0.481 0.001 1.617 [1.587 1.647]#

P3491 Thoracentesis None 0.310 0.018 1.363 [1.357 1.369]#

P3492 Injection into thoracic cavity None 0.434 0.002 1.543 [1.525 1.561]#

P3512 Open heart valvuloplasty of mitral valve without replacement None 0.392 0.001 1.480 [1.457 1.504]#

P352 Replacement of heart valve All subcodes except 3521, 3522 and 3524 0.545 0.001 1.724 [1.693 1.755]#

P3521 Replacement of aortic valve with tissue graft None 0.399 0.003 1.491 [1.477 1.506]#

P3522 Other replacement of aortic valve None 0.452 0.002 1.572 [1.554 1.590]#

P3524 Other replacement of mitral valve None 0.567 0.001 1.763 [1.733 1.794]#

Single vessel percutaneous transluminal coronary angioplasty or coronary atherectomy without

P3601 mention of thrombolytic agent None -0.104 0.038 0.901 [0.897 0.904]#

P3606 Insertion of non-drug-eluting coronary artery stent(s) None -0.131 0.027 0.877 [0.873 0.880]#

P3607 Insertion of drug-eluting coronary artery stent(s) None -0.296 0.026 0.744 [0.741 0.747]#

All subcodes except 3611, 3612, 3613, 3614 and

P361 Bypass anastomosis for heart revascularization 3615 0.290 0.001 1.337 [1.316 1.358]^^^

P3611 (Aorto)coronary bypass of one coronary artery None 0.571 0.004 1.770 [1.754 1.786]#

P3612 (Aorto)coronary bypass of two coronary arteries None 0.634 0.009 1.885 [1.871 1.900]#

P3613 (Aorto)coronary bypass of three coronary arteries None 0.651 0.008 1.918 [1.903 1.933]#

P3614 (Aorto)coronary bypass of four or more coronary arteries None 0.665 0.004 1.945 [1.927 1.963]#

P3615 Single internal mammary-coronary artery bypass None 0.236 0.020 1.266 [1.259 1.274]#

P370 Pericardiocentesis All subcodes 0.268 0.001 1.307 [1.278 1.336]^^

P3712 Pericardiotomy None 0.486 0.001 1.625 [1.596 1.655]#

P3721 Right heart cardiac catheterization None 0.484 0.001 1.622 [1.599 1.644]#

P3722 Left heart cardiac catheterization None 0.262 0.095 1.300 [1.295 1.306]#

P3723 Combined right and left heart cardiac catheterization None 0.402 0.014 1.495 [1.487 1.503]#

P3726 Catheter based invasive electrophysiologic testing None 0.166 0.009 1.181 [1.174 1.189]#

P373 Pericardiectomy and excision of lesion of heart All subcodes except 3734 0.221 0.001 1.247 [1.229 1.265]^^

P3734 Excision or destruction of other lesion or tissue of heart, other approach None -0.152 0.003 0.859 [0.851 0.867]^^^

P3761 Implant of pulsation balloon None 0.326 0.003 1.386 [1.373 1.399]#

Insertion, revision, replacement and removal of leads; insertion of temp pacemaker; or revision of

P377 cardiac device pocket All subcodes except 3778 0.058 0.026 1.060 [1.050 1.071]***

P3778 Insertion of temporary transvenous pacemaker system None 0.175 0.003 1.191 [1.180 1.201]#

P378 Insertion, replacement, removal, and revision of pacemaker device All subcodes except 3782 and 3783 0.199 0.005 1.220 [1.207 1.233]^^^

P3782 Initial insertion of single-chamber device, rate responsive None 0.290 0.003 1.337 [1.318 1.355]#

P3783 Initial insertion of dual-chamber device None 0.197 0.019 1.218 [1.205 1.231]^^^

P379 Other operations on heart and pericardium All subcodes 0.127 0.007 1.135 [1.128 1.143]#

P380 Incision of vessel All subcodes except 3808 0.276 0.001 1.318 [1.295 1.341]^^^

P3808 Incision of vessel, lower limb arteries None 0.305 0.002 1.357 [1.339 1.375]#

P3818 Endarterectomy, lower limb arteries None 0.183 0.002 1.201 [1.188 1.214]^^^

P3821 Biopsy of blood vessel None 0.618 0.001 1.855 [1.824 1.887]#

P384 Resection of vessel with replacement All subcodes except 3844 0.354 0.001 1.425 [1.403 1.447]#

P3844 Resection of vessel with replacement, aorta, abdominal None 0.846 0.002 2.330 [2.305 2.356]#

P387 Interruption of the vena cava All subcodes 0.225 0.007 1.252 [1.243 1.260]#

P388 Other surgical occlusion of vessels All subcodes 0.258 0.001 1.294 [1.269 1.319]^^

P3893 Venous catheterization, not elsewhere classified None 0.413 0.069 1.511 [1.508 1.514]#

P3895 Venous catheterization for renal dialysis None 0.437 0.011 1.548 [1.539 1.556]#

P3898 Other puncture of artery None 0.093 0.004 1.097 [1.089 1.105]^^

P3925 Aorta-iliac-femoral bypass None 0.744 0.001 2.104 [2.076 2.132]#

P3927 Arteriovenostomy for renal dialysis None 0.360 0.003 1.433 [1.419 1.448]#

P3929 Other (peripheral) vascular shunt or bypass None 0.609 0.008 1.838 [1.826 1.849]#

P394 Revision of vascular procedure All subcodes except 3949 0.098 0.002 1.103 [1.089 1.118]***

P3949 Other revision of vascular procedure None 0.292 0.003 1.339 [1.327 1.352]#

P395 Other repair of vessels All subcodes except 3952 0.101 0.014 1.106 [1.099 1.112]^^^

P3952 Other repair of aneurysm None 0.551 0.001 1.735 [1.707 1.762]#

P3961 Extracorporeal circulation auxiliary to open heart surgery None 0.229 0.022 1.257 [1.250 1.264]#

P399 Other operations on vessels All subcodes except 3990 and 3995 0.234 0.001 1.264 [1.243 1.286]^^

P3990 Insertion of non-drug-eluting peripheral (non-coronary) vessel stent(s) None -0.183 0.007 0.833 [0.826 0.839]#

P3995 Hemodialysis None 0.144 0.042 1.155 [1.151 1.159]#

P4011 Biopsy of lymphatic structure None 0.188 0.004 1.207 [1.198 1.217]#

P4023 Excision of axillary lymph node None -0.290 0.001 0.748 [0.737 0.759]#

P403 Regional lymph node excision All subcodes 0.154 0.005 1.166 [1.158 1.174]#

P405 Radical excision of other lymph nodes All subcodes 0.243 0.001 1.275 [1.256 1.295]^^^

P4131 Biopsy of bone marrow None 0.523 0.007 1.687 [1.676 1.698]#

P415 Total splenectomy All subcodes 0.599 0.001 1.820 [1.792 1.848]#

P4223 Other esophagoscopy None 0.185 0.006 1.203 [1.196 1.211]#

P4233 Endoscopic excision or destruction of lesion or tissue of esophagus None 0.219 0.001 1.245 [1.228 1.261]^^^

P4311 Percutaneous [endoscopic] gastrostomy [PEG] None 0.534 0.017 1.706 [1.698 1.713]#

P4319 Other gastrostomy None 0.511 0.002 1.667 [1.648 1.686]#

P4341 Endoscopic excision or destruction of lesion or tissue of stomach None 0.122 0.002 1.130 [1.116 1.144]^

P442 Pyloroplasty All subcodes 0.386 0.001 1.471 [1.442 1.500]#

P4439 Other gastroenterostomy without gastrectomy None 0.669 0.001 1.952 [1.912 1.993]#

P444 Control of hemorrhage and suture of ulcer of stomach or duodenum All subcodes except 4443 0.584 0.001 1.793 [1.759 1.827]#

P4443 Endoscopic control of gastric or duodenal bleeding None 0.240 0.007 1.271 [1.263 1.279]#

P4466 Other procedures for creation of esophagogastric sphincteric competence None 0.313 0.001 1.367 [1.345 1.390]^^^

P451 Diagnostic procedures on small intestine All subcodes except 4513 and 4516 0.226 0.001 1.253 [1.230 1.277]^^

P4513 Other endoscopy of small intestine None 0.281 0.039 1.324 [1.320 1.327]#

P4516 Esophagogastroduodenoscopy [EGD] with closed biopsy None 0.250 0.052 1.284 [1.280 1.287]#

P4523 Colonoscopy None 0.248 0.030 1.282 [1.277 1.286]#

P4524 Flexible sigmoidoscopy None 0.309 0.005 1.362 [1.352 1.372]#

P4525 Closed [endoscopic] biopsy of large intestine None 0.288 0.018 1.334 [1.329 1.340]#

P453 Local excision or destruction of lesion or tissue of small intestine All subcodes 0.218 0.001 1.243 [1.221 1.265]^^

P4542 Endoscopic polypectomy of large intestine None 0.141 0.013 1.152 [1.146 1.159]#

P4562 Other partial resection of small intestine None 0.440 0.004 1.553 [1.541 1.566]#

All subcodes except 4573, 4574, 4575, 4576 and

P457 Open and other partial excision of large intestine 4579 0.427 0.001 1.533 [1.504 1.562]#

P4573 Open and other right hemicolectomy None 0.668 0.008 1.950 [1.935 1.965]#

P4574 Open and other resection of transverse colon None 0.529 0.001 1.698 [1.668 1.729]#

P4575 Open and other left hemicolectomy None 0.634 0.002 1.886 [1.865 1.908]#

P4576 Open and other sigmoidectomy None 0.590 0.006 1.804 [1.789 1.819]#

P4579 Other and unspecified partial excision of large intestine None 0.539 0.001 1.715 [1.693 1.738]#

P4593 Other small-to-large intestinal anastomosis None 0.174 0.002 1.190 [1.177 1.203]^^^









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al





Webtable 2C. RSILOS Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

P4603 Exteriorization of large intestine None 0.540 0.001 1.716 [1.684 1.749]#

P4610 Colostomy, not otherwise specified None 0.187 0.002 1.206 [1.191 1.220]^^

P4611 Temporary colostomy None 0.197 0.001 1.218 [1.197 1.240]^^

P4613 Permanent colostomy None 0.267 0.001 1.306 [1.281 1.332]^^

P462 Ileostomy All subcodes 0.293 0.001 1.340 [1.317 1.363]^^^

P4639 Other enterostomy None 0.709 0.001 2.031 [2.003 2.060]#

P464 Revision of intestinal stoma All subcodes 0.202 0.001 1.224 [1.196 1.252]^

P4652 Closure of stoma of large intestine None 0.180 0.002 1.197 [1.178 1.217]^^

P467 Other repair of intestine All subcodes except 4673 0.299 0.001 1.349 [1.327 1.371]^^^

P4673 Suture of laceration of small intestine, except duodenum None 0.177 0.001 1.194 [1.173 1.215]^

P4685 Dilation of intestine None 0.304 0.001 1.355 [1.331 1.379]^^^

P4709 Other appendectomy None 0.199 0.002 1.220 [1.205 1.235]^^^

P4719 Other incidental appendectomy None 0.163 0.002 1.177 [1.162 1.191]^^

P4823 Rigid proctosigmoidoscopy None 0.180 0.002 1.197 [1.182 1.212]^^

P4824 Closed [endoscopic] biopsy of rectum None 0.213 0.003 1.237 [1.225 1.249]#

P485 Abdominoperineal resection of rectum All subcodes 0.891 0.001 2.438 [2.390 2.487]#

P486 Other resection of rectum All subcodes except 4863 0.507 0.001 1.660 [1.629 1.693]#

P4863 Other anterior resection of rectum None 0.694 0.002 2.002 [1.976 2.029]#

P494 Procedures on hemorrhoids All subcodes 0.205 0.000 1.228 [1.200 1.257]^

P5011 Closed (percutaneous) [needle] biopsy of liver None 0.442 0.003 1.556 [1.542 1.570]#

P5012 Open biopsy of liver None 0.211 0.001 1.235 [1.218 1.252]^^

P5110 Endoscopic retrograde cholangiopancreatography [ERCP] None 0.390 0.003 1.477 [1.463 1.491]#

P5122 Cholecystectomy None 0.478 0.007 1.613 [1.601 1.626]#

P5123 Laparoscopic cholecystectomy None 0.107 0.015 1.113 [1.106 1.120]^^^

P514 Incision of bile duct for relief of obstruction All subcodes 0.427 0.001 1.533 [1.503 1.562]#

P5185 Endoscopic sphincterotomy and papillotomy None 0.241 0.006 1.272 [1.262 1.282]#

P5187 Endoscopic insertion of stent (tube) into bile duct None 0.173 0.003 1.189 [1.176 1.202]^^^

P5198 Other percutaneous procedures on biliary tract None 0.551 0.001 1.735 [1.702 1.767]#

P521 Diagnostic procedures on pancreas All subcodes 0.360 0.001 1.433 [1.406 1.461]^^^

P5361 Other open incisional hernia repair with graft or prosthesis None 0.184 0.003 1.202 [1.192 1.213]#

P540 Incision of abdominal wall All subcodes 0.306 0.001 1.358 [1.335 1.382]^^^

P5411 Exploratory laparotomy None 0.396 0.001 1.486 [1.467 1.506]#

P5419 Other laparotomy None 0.363 0.001 1.438 [1.412 1.466]#

P542 Diagnostic procedures of abdominal region All subcodes except 5423 0.075 0.004 1.078 [1.070 1.087]^

P5423 Biopsy of peritoneum None 0.200 0.001 1.222 [1.205 1.239]^^

P544 Excision or destruction of peritoneal tissue All subcodes 0.218 0.003 1.244 [1.232 1.256]#

P5459 Other lysis of peritoneal adhesions None 0.330 0.012 1.391 [1.383 1.399]#

P546 Suture of abdominal wall and peritoneum All subcodes 0.274 0.001 1.315 [1.286 1.345]^^

P549 Other operations of abdominal region All subcodes except 5491 and 5498 0.299 0.001 1.348 [1.324 1.373]^^^

P5491 Percutaneous abdominal drainage None 0.393 0.007 1.482 [1.472 1.492]#

P5498 Peritoneal dialysis None 0.197 0.001 1.218 [1.202 1.235]^^

P5503 Percutaneous nephrostomy without fragmentation None 0.412 0.002 1.510 [1.490 1.529]#

P5523 Closed [percutaneous] [needle] biopsy of kidney None 0.365 0.001 1.441 [1.418 1.464]#

P5551 Nephroureterectomy None 0.446 0.003 1.562 [1.542 1.581]#

P5569 Other kidney transplantation None 0.777 0.000 2.176 [2.113 2.241]#

P5651 Formation of cutaneous uretero-ileostomy None 1.136 0.001 3.113 [3.056 3.171]#

P570 Transurethral clearance of bladder All subcodes 0.214 0.003 1.239 [1.226 1.251]#

P5718 Other suprapubic cystostomy None 0.290 0.001 1.337 [1.316 1.357]^^^

P5732 Other cystoscopy None 0.178 0.012 1.195 [1.189 1.200]#

P5733 Closed [transurethral] biopsy of bladder None 0.127 0.001 1.135 [1.121 1.150]^

P578 Other repair of urinary bladder All subcodes 0.275 0.001 1.316 [1.290 1.342]^^

P5794 Insertion of indwelling urinary catheter None -0.040 0.009 0.961 [0.956 0.966]^

P5979 Other repair of urinary stress incontinence None -0.270 0.003 0.763 [0.756 0.770]#

P598 Ureteral catheterization All subcodes 0.077 0.008 1.080 [1.072 1.087]^^

P6011 Closed [percutaneous] [needle] biopsy of prostate None 0.412 0.001 1.510 [1.486 1.535]#

P6029 Other transurethral prostatectomy None -0.129 0.012 0.879 [0.875 0.884]#

P684 Total abdominal hysterectomy All subcodes 0.215 0.005 1.240 [1.229 1.250]#

P6859 Other and unspecified vaginal hysterectomy None -0.079 0.003 0.924 [0.915 0.932]^

P6909 Other dilation and curettage None 0.361 0.001 1.435 [1.409 1.462]#

P7052 Repair of rectocele None -0.172 0.002 0.842 [0.831 0.853]^^

P7077 Vaginal suspension and fixation None 0.126 0.002 1.134 [1.121 1.148]^^

P774 Biopsy of bone All subcodes except 7749 0.272 0.001 1.313 [1.287 1.339]^^

P7749 Biopsy of bone, other bones None 0.241 0.002 1.273 [1.259 1.286]#

P776 Local excision of lesion or tissue of bone All subcodes except 7769 0.243 0.001 1.275 [1.258 1.292]^^^

P7769 Local excision of lesion or tissue of bone, other bones None 0.215 0.001 1.240 [1.220 1.261]^^

P7789 Other partial ostectomy, other bones None 0.230 0.001 1.258 [1.234 1.283]^^

P785 Internal fixation of bone without fracture reduction All subcodes except 7855 0.229 0.000 1.257 [1.228 1.287]^

P7855 Internal fixation of bone without fracture reduction, femur None 0.369 0.003 1.446 [1.432 1.460]#

P790 Closed reduction of fracture without internal fixation All subcodes 0.160 0.003 1.174 [1.162 1.187]^^^

P7915 Closed reduction of fracture with internal fixation, femur None 0.351 0.005 1.420 [1.408 1.432]#

P7935 Open reduction of fracture with internal fixation, femur None 0.429 0.019 1.536 [1.525 1.546]#

P7936 Open reduction of fracture with internal fixation, tibia and fibula None 0.296 0.004 1.344 [1.329 1.359]#

P796 Debridement of open fracture site All subcodes 0.349 0.001 1.417 [1.392 1.444]^^^

P800 Arthrotomy for removal of prosthesis All subcodes 0.265 0.001 1.304 [1.282 1.326]^^^

P801 Other arthrotomy All subcodes 0.226 0.001 1.254 [1.235 1.274]^^

P802 Arthroscopy All subcodes -0.127 0.001 0.881 [0.866 0.896]***

P8051 Excision of intervertebral disc None -0.079 0.009 0.924 [0.918 0.931]^^

P8086 Other local excision or destruction of lesion of joint, knee None 0.195 0.001 1.215 [1.194 1.237]^^

P810 Spinal fusion All subcodes except 8102, 8107 and 8108 0.640 0.002 1.896 [1.871 1.920]#

P8102 Other cervical fusion, anterior technique None -0.207 0.003 0.813 [0.803 0.823]^^^

P8107 Lumbar and lumbosacral fusion, lateral transverse process technique None 0.489 0.001 1.630 [1.601 1.658]#

P8108 Lumbar and lumbosacral fusion, posterior technique None 0.536 0.005 1.709 [1.695 1.724]#

P813 Refusion of spine All subcodes 0.418 0.000 1.519 [1.484 1.554]^^^

P8151 Total hip replacement None 0.466 0.018 1.594 [1.588 1.600]#

P8152 Partial hip replacement None 0.516 0.014 1.676 [1.666 1.687]#

P8153 Revision of hip replacement, not otherwise specified None 0.458 0.003 1.581 [1.564 1.597]#

P8154 Total knee replacement None 0.376 0.038 1.457 [1.450 1.465]#

P8155 Revision of knee replacement, not otherwise specified None 0.277 0.003 1.319 [1.305 1.333]#

P8162 Fusion or refusion of 2-3 vertebrae None -0.138 0.004 0.871 [0.863 0.880]^^

P8165 Percutaneous vertebroplasty None 0.214 0.001 1.239 [1.216 1.264]^^

P8166 Percutaneous vertebral augmentation None -0.313 0.002 0.731 [0.722 0.741]#

P8183 Other repair of shoulder None -0.228 0.001 0.796 [0.783 0.810]^^

P8191 Arthrocentesis None 0.296 0.005 1.344 [1.333 1.354]#

P8192 Injection of therapeutic substance into joint or ligament None 0.281 0.004 1.325 [1.313 1.337]#

P830 Incision of muscle, tendon, fascia, and bursa All subcodes 0.272 0.001 1.313 [1.288 1.340]^^

P831 Division of muscle, tendon, and fascia All subcodes 0.259 0.001 1.295 [1.270 1.320]^^

P8321 Biopsy of soft tissue None 0.530 0.001 1.699 [1.672 1.728]#

P8345 Other myectomy None 0.441 0.001 1.555 [1.529 1.581]#

P8363 Rotator cuff repair None -0.451 0.003 0.637 [0.630 0.644]#

P838 Other plastic operations on muscle, tendon, and fascia All subcodes 0.261 0.001 1.298 [1.278 1.319]^^^

P839 Other operations on muscle, tendon, fascia, and bursa All subcodes 0.313 0.001 1.368 [1.341 1.397]^^

P8411 Amputation of toe None 0.338 0.004 1.402 [1.389 1.415]#

P8412 Amputation through foot None 0.583 0.001 1.792 [1.764 1.821]#

P8415 Other amputation below knee None 0.624 0.003 1.866 [1.847 1.886]#

P8417 Amputation above knee None 0.484 0.003 1.622 [1.606 1.638]#

P843 Revision of amputation stump All subcodes 0.396 0.001 1.486 [1.461 1.513]#

P851 Diagnostic procedures on breast All subcodes 0.423 0.001 1.527 [1.498 1.557]#

P8601 Aspiration of skin and subcutaneous tissue None 0.298 0.001 1.347 [1.323 1.372]^^^









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al





Webtable 2C. RSILOS Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

P8604 Other incision with drainage of skin and subcutaneous tissue None 0.241 0.006 1.273 [1.264 1.281]#

P8605 Incision with removal of foreign body or device from skin and subcutaneous tissue None 0.098 0.002 1.103 [1.092 1.115]^

P8607 Insertion of totally implantable vascular access device [VAD] None 0.433 0.005 1.542 [1.531 1.554]#

P8611 Biopsy of skin and subcutaneous tissue None 0.465 0.001 1.592 [1.572 1.614]#

P8622 Excisional debridement of wound, infection, or burn None 0.501 0.015 1.651 [1.643 1.658]#

P8627 Debridement of nail, nail bed, or nail fold None 0.707 0.005 2.028 [2.013 2.044]#

P8628 Nonexcisional debridement of wound, infection or burn None 0.401 0.004 1.494 [1.482 1.506]#



P863 Other local excision or destruction of lesion or tissue of skin and subcutaneous tissue All subcodes 0.173 0.003 1.189 [1.177 1.200]^^^

P8669 Other skin graft to other sites None 0.817 0.002 2.264 [2.238 2.291]#

P8674 Attachment of pedicle or flap graft to other sites None 0.446 0.001 1.562 [1.539 1.585]#

P868 Other repair and reconstruction of skin and subcutaneous tissue All subcodes 0.194 0.000 1.214 [1.186 1.243]^

P8703 Computerized axial tomography of head None 0.082 0.020 1.085 [1.081 1.089]#

P8721 Contrast myelogram None 0.638 0.001 1.893 [1.858 1.928]#

P8741 Computerized axial tomography of thorax None 0.127 0.009 1.135 [1.129 1.141]#

P8744 Routine chest x-ray, so described None 0.261 0.002 1.298 [1.283 1.313]#

P875 Biliary tract x-ray All subcodes 0.059 0.009 1.061 [1.054 1.068]^

P876 Other x-ray of digestive system All subcodes except 8761 0.276 0.001 1.318 [1.296 1.340]^^^

P8761 Barium swallow None 0.759 0.001 2.136 [2.099 2.174]#

P877 X-ray of urinary system All subcodes 0.139 0.008 1.149 [1.142 1.157]#

P8801 Computerized axial tomography of abdomen None 0.161 0.012 1.175 [1.169 1.180]#

P8838 Other computerized axial tomography None 0.126 0.004 1.134 [1.125 1.143]^^^

P8841 Arteriography of cerebral arteries None 0.236 0.010 1.266 [1.259 1.273]#

P8842 Aortography None 0.093 0.019 1.098 [1.094 1.102]#

P8847 Arteriography of other intra-abdominal arteries None 0.148 0.004 1.159 [1.150 1.169]^^^

P8848 Arteriography of femoral and other lower extremity arteries None 0.104 0.014 1.110 [1.104 1.115]#

P8849 Arteriography of other specified sites None 0.107 0.002 1.113 [1.102 1.125]^

P8853 Angiocardiography of left heart structures None -0.077 0.084 0.926 [0.923 0.929]#

P8856 Coronary arteriography using two catheters None -0.017 0.101 0.983 [0.979 0.987]**

P8872 Diagnostic ultrasound of heart None 0.125 0.044 1.133 [1.130 1.136]#

P8875 Diagnostic ultrasound of urinary system None 0.234 0.003 1.264 [1.252 1.277]#

P8877 Diagnostic ultrasound of peripheral vascular system None 0.263 0.007 1.301 [1.293 1.309]#

P8879 Other diagnostic ultrasound None 0.223 0.001 1.250 [1.229 1.271]^^

P8891 Magnetic resonance imaging of brain and brain stem None 0.107 0.009 1.113 [1.107 1.119]#

P8893 Magnetic resonance imaging of spinal canal None 0.391 0.003 1.478 [1.463 1.492]#

P8894 Magnetic resonance imaging of musculoskeletal None 0.361 0.001 1.435 [1.413 1.458]#

P8897 Magnetic resonance imaging of other and unspecified sites None 0.173 0.002 1.189 [1.177 1.202]^^^

Anatomic and physiologic measurements and manual examinations -- nervous system and sense

P891 organs All subcodes except 8914 0.216 0.000 1.241 [1.213 1.269]^

P8914 Electroencephalogram None 0.245 0.003 1.278 [1.266 1.290]#



P892 Anatomic and physiologic measurements and manual examinations -- genitourinary system All subcodes except 8922 0.191 0.001 1.211 [1.186 1.237]^

P8922 Cystometrogram None 0.534 0.001 1.706 [1.674 1.739]#

P8937 Vital capacity determination None 0.241 0.001 1.272 [1.249 1.295]^^

P8941 Cardiovascular stress test using treadmill None -0.212 0.001 0.809 [0.799 0.820]^^^

P8944 Other cardiovascular stress test None 0.069 0.007 1.071 [1.064 1.078]^

P8950 Ambulatory cardiac monitoring None 0.316 0.001 1.371 [1.346 1.397]^^^

P8959 Other nonoperative cardiac and vascular measurements None 0.212 0.002 1.236 [1.222 1.250]^^^

P8962 Central venous pressure monitoring None 0.225 0.001 1.252 [1.231 1.273]^^

P8964 Pulmonary artery wedge monitoring None 0.158 0.004 1.171 [1.162 1.181]#

P8965 Measurement of systemic arterial blood gases None 0.097 0.004 1.102 [1.094 1.111]^^

P8968 Monitoring of cardiac output by other technique None 0.166 0.002 1.181 [1.168 1.195]^^

P920 Radioisotope scan and function study All subcodes 0.122 0.005 1.130 [1.122 1.138]^^^

P9214 Bone scan None 0.385 0.002 1.470 [1.453 1.487]#

P9215 Pulmonary scan None 0.110 0.002 1.116 [1.103 1.128]^

P9224 Teleradiotherapy using photons None 0.543 0.001 1.722 [1.698 1.746]#

P9227 Implantation or insertion of radioactive elements None -0.222 0.002 0.801 [0.792 0.811]#

P9229 Other radiotherapeutic procedure None 0.546 0.004 1.727 [1.713 1.742]#

P9311 Assisting exercise None 0.190 0.001 1.209 [1.189 1.230]^^

P9322 Ambulation and gait training None 0.195 0.003 1.215 [1.204 1.226]#

P9338 Combined physical therapy without mention of the components None 0.307 0.002 1.360 [1.343 1.376]#

P9339 Other physical therapy None 0.265 0.025 1.304 [1.298 1.310]#

P934 Skeletal traction and other traction All subcodes 0.243 0.001 1.275 [1.249 1.300]^^

P935 Other immobilization, pressure, and attention to wound All subcodes except 9353 and 9359 0.170 0.002 1.185 [1.173 1.198]^^^

P9353 Application of other cast None 0.171 0.001 1.186 [1.166 1.206]^

P9359 Other immobilization, pressure, and attention to wound None 0.253 0.002 1.288 [1.271 1.304]#

P9375 Other speech training and therapy None 0.187 0.004 1.206 [1.196 1.216]#

P9383 Occupational therapy None 0.344 0.021 1.410 [1.402 1.418]#

P9389 Rehabilitation, not elsewhere classified None 0.479 0.001 1.614 [1.592 1.635]#

P9390 Non-invasive mechanical ventilation None 0.218 0.008 1.243 [1.235 1.250]#

P9394 Respiratory medication administered by nebulizer None 0.226 0.008 1.254 [1.247 1.261]#

P9399 Other respiratory procedures None 0.174 0.001 1.190 [1.170 1.210]^

P9425 Other psychiatric drug therapy None 1.172 0.001 3.229 [3.174 3.286]#

P9427 Other electroshock therapy None 1.897 0.001 6.663 [6.551 6.777]#

P9444 Other group therapy None 1.003 0.001 2.727 [2.682 2.771]#

P9462 Alcohol detoxification None 0.246 0.002 1.279 [1.263 1.296]#

P9463 Alcohol rehabilitation and detoxification None 1.250 0.000 3.492 [3.379 3.609]#

P9465 Drug detoxification None 0.474 0.000 1.607 [1.551 1.664]^^

P9607 Insertion of other (naso-)gastric tube None 0.063 0.006 1.065 [1.058 1.072]^

P9656 Other lavage of bronchus and trachea None 0.218 0.002 1.244 [1.228 1.260]^^^

P9659 Other irrigation of wound None 0.213 0.001 1.238 [1.214 1.261]^^

P966 Enteral infusion of concentrated nutritional substances All subcodes 0.279 0.011 1.322 [1.315 1.329]#

P9671 Continuous invasive mechanical ventilation for less than 96 consecutive hours None 0.141 0.020 1.151 [1.147 1.156]#

P9672 Continuous invasive mechanical ventilation for 96 consecutive hours or more None 0.583 0.013 1.792 [1.782 1.802]#

P9723 Replacement of tracheostomy tube None 0.375 0.001 1.455 [1.423 1.489]^^^

P978 Other nonoperative removal of therapeutic device All subcodes 0.336 0.001 1.400 [1.372 1.428]^^^

P9903 Other transfusion of whole blood None 0.343 0.001 1.409 [1.382 1.437]^^^

P9904 Transfusion of packed cells None 0.151 0.132 1.163 [1.162 1.165]#

P9905 Transfusion of platelets None 0.144 0.006 1.155 [1.147 1.163]#

P9907 Transfusion of other serum None 0.069 0.014 1.071 [1.067 1.076]^^^

P9910 Injection or infusion of thrombolytic agent None 0.116 0.004 1.123 [1.113 1.132]^^

P9915 Parenteral infusion of concentrated nutritional substances None 0.443 0.009 1.557 [1.549 1.566]#

P9920 Injection or infusion of platelet inhibitor None -0.101 0.019 0.904 [0.900 0.907]#

P9921 Injection of antibiotic None 0.114 0.012 1.121 [1.116 1.126]#

P9923 Injection of steroid None 0.143 0.008 1.154 [1.145 1.163]^^^

P9925 Injection or infusion of cancer chemotherapeutic substance None 0.359 0.009 1.432 [1.424 1.440]#

P9961 Atrial cardioversion None 0.132 0.004 1.141 [1.132 1.150]^^^

P9962 Other electric countershock of heart None 0.109 0.005 1.115 [1.107 1.122]^^^

Therapeutic apheresis or other injection, administration, or infusion of other therapeutic or

P997 prophylactic substance All subcodes 0.244 0.001 1.276 [1.258 1.294]^^^

P9999 Other miscellaneous procedures None 0.354 0.001 1.425 [1.401 1.448]#



P_ Symbol P Value

#

< 10-300

^^^

< 10-200

^^

< 10-100

^

< 10-50

***

< 10-25









eTable 2 Predictors and Coefficients

Broadly Applicable Risk Stratification Sessler, et al





Webtable 2C. RSILOS Predictors and Coefficients





AHRQ (CCS)

Predictors Description ICD-9-CM Codes included in Covariate Complication Code Coefficient (Beta) Covariate Mean Hazard Ratio [95% CI]

**

< 10-10

*

< 0.005









eTable 2 Predictors and Coefficients