+ Mast de-
Broncho- Chemo- + Rolling/
vascular Vasoactive Fever Pain granulatio + Mucus Stimulated x Released x Other
active attractant Adhesion
perm. n
dilation Trauma, heat,
(arterioles, Masts,
IgE binding to Immediate Transient
Histamine post- Platelets, + selectins
FcR, C3a/5a, Inflammation, EC activation
capillary Basophils
PAF
venules)
dilation
(arterioles,
5HT PAF Platelets
post-
capillary
venules) via AA Kallikrein + Immediate (Sustained)
constrictio Tissue damage
Bradykinin dilation metab- Kininogen, or Inflammation. + AA metabolism.
n (collagen)
olism Plasmin ASTHMA
Leukocytes, + selectins,
PAF dilation Oxidative Burst
ECs + adhesion
Masts,
PGs Delayed Pronlonged
? dilation E2 E2 leukocytes +selectins
D2,E2,F2 Inflammation
(local acting)
Cysteinyl Mast cells, CysLT1/2R on ECs, WBCs,
constrictio vascular SM -> activation.
LT's constriction leukocytes
n ASTHMA. Delayed-Prolonged
C4,D4,E4 (local acting)
PMNs, Mast cells, Inflammation
Chemotaxis, Delayed-Prolonged
LTB4, C3A monocyte leukocytes + adhesion
Inflammation
s (local acting)
Macrophages, +selectin, systemic acute phase,
Trauma, heat,
ILI/TNF lymphocytes, I/VCAM1, (Immediate) Sustained
injury, etc.
Masts, ECs MAC1 Inflammation, SEPTIC SHOCK
+
C5a PMNs macrophage Anaphylatoxin, Mast activation
adhesion
Anaphylatoxin, (Immediate)
C3a constriction Plasmin Sustained Inflammation, Mast
activation
C3b Plasmin
Classic,
C5b-->C9 Alternative, MAC Complex lyses cells
Lectin
pathways
Free Necrosis, Thrombosis,
Leukocytes + adhesion
Radicals +cytokines, +chemokines
inhibits PAF, decreases
Macrophages,
NO dilation leukocyte recruitment, kills
endothelium
pathogens
dilation
Fibrin binds Mac1 on
(fibrin
Fibrin macrophages -> TGF-beta
cleavage
release -> collagen production
products)