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									                                              VOL. XX, No. 2
                                                January, 2004




             -NEWSLETTER-

       Reproductive &
       Developmental
         Toxicology
A Specialty Section of the Society of Toxicology




        Editor: Ronald D. Hood
                R. D. Hood & Associates
                Toxicology Consultants
                Box 870344
                Tuscaloosa, AL 35487-0344
                TEL: (205) 348-1817
                FAX: (205) 348-1786
                E-mail: rhood@bsc.as.ua.edu
                                                    1



       PRESIDENT’S MESSAGE                              program proposals for the annual meeting. What
                                                        most attracts scientists in reproductive and
We’re getting close to time for the annual              developmental toxicology to the SOT meeting is
Society of Toxicology meeting in Baltimore,             the number of quality sessions in or related to our
and I wanted to let you know                            specific area. These programs come from
about some of the things that                           submitted proposals, mainly (if not all) from
will be happening related                               involved RDTSS members.
to our Specialty Section.
We have a strong                                        Another important contribution of the Specialty
program lined up that the                               Section is to encourage and foster students
RDTSS is sponsoring or                                  interested in a career in our area. This year, we
co-sponsoring for this                                  are hoping to attract as many students as possible
year’s meeting. These                                   to the meeting, and a program has been planned to
include one continuing                                  encourage students interested in jobs in
education course, three                                 reproductive and developmental toxicology. This
symposia, three workshops, and a roundtable             program, titled “Where the Jobs Are – In
(see further details below). In addition, be sure       Reproductive and Developmental Toxicology,‖
to check out the large number of platform and           will include a panel of experts representing
poster sessions with submitted papers related to        different employment sectors. Each has been
reproductive and developmental toxicity.                asked to give a brief overview of how students
                                                        should prepare themselves in terms of training,
RDT Specialty Section Meeting                           how diverse or focused that training should be,
Don’t miss the RDT Specialty Section meeting,           and what the prospects are for employment in each
to be held Tuesday, March 23, 6:00-7:30 pm at           sector. A discussion period will follow, during
the Baltimore Convention Center in Room 325.            which students will be encouraged to ask
This year we will have at least one sponsor for         questions. The panelists include:
the Specialty Section reception (Endo
Pharmaceuticals), and an exhibit by the                  Academia – Dr. Thomas Knudsen, University
Teratology Society. Student Awards will be                of Louisville
announced for the best presentations at this             Pharmaceutical Industry – Dr. Dana Shuey,
year’s meeting, and the Best Journal Paper                Endo Pharmaceuticals
Awards will be presented for papers published            Chemical Industry – Dr. George Daston,
on reproductive and developmental toxicology              Proctor & Gamble
in 2003 in Toxicology and Applied                        Government – Dr. William Slikker,
Pharmacology and in Toxicological Sciences.               NCTR/FDA
New officers will be announced, and outgoing             Contract Laboratory Industry – Dr. Rochelle
officers will be honored.                                 Tyl, Research Triangle Institute

Also at the Specialty Section meeting, we will          Please plan to attend the meeting and bring your
review proposed program ideas for next year so          students and postdoctoral fellows with you!
be sure to submit your proposals to John
Rogers, Vice President, as soon as possible (see        Membership
call for proposals below). Remember that one            Our members are our most important assets! That
of the most important contributions of a                may sound trite, but you should be aware that
Specialty Section is the effort to develop              membership in our Specialty Section (as in many
                                                   2
others) has been going down over the past              advance the field and sponsor student events,
several years. For example, in 1999, the               awards, or other aspects of the Specialty Section.
number of members in RDTSS has gone from               Finally, in closing, I look forward to seeing all of
223 (198 paid) in 1999 to 187 (182 paid) in            you at the SOT and RDTSS meetings in Baltimore
2003. In addition, we currently have only 4            next month. If you have any suggestions or
student members. So please make sure to join           comments, please feel free to contact me at
RDTSS each year when you pay your dues for             kimmel.carole@epa.gov.
SOT. Our primary income comes from
membership dues. Also, be sure to access the           Carole Kimmel


     400
                                                                                       Bio Mod
                                                                                       CV
     350
                                                                                       Carcin
                                                                                       Dermal
     300                                                                               Epid
                                                                                       FS
     250                                                                               Immun
                                                                                       In Vitro
                                                                                       Inhal
     200
                                                                                       Mech
                                                                                       Metals
     150                                                                               Mol Bio
                                                                                       Neurotox
     100                                                                               Occ Health
                                                                                       Reg Saf
                                                                                       Repro Dev
      50
                                                                                       Risk A
                                                                                       Tox Explor
       0                                                                               WIT
              1999          2000          2001           2002          2003

SOT website online directory to make confirm
that your membership information is correct
and that you are indeed an up-to-date member                SOT ANNUAL MEETING 2004
of the Specialty Section.
                                                       Numerous RDTSS-related activities are on tap for
                                                                  the 43rd Annual meeting of the
Specialty Section Sponsorship                                     Society of Toxicology in
We encourage sponsorship of the Specialty                              Baltimore, Maryland. The
Section by companies that are not SOT                                  following scientific sessions
sponsors. If you work for a company or                                   are being sponsored or
organization that might be interested in                                 cosponsored by the RDTSS
sponsoring the RDTSS reception or one or                                in 2004:
more of the awards, I encourage you to contact
one of our officers. As indicated earlier, we
have at least one sponsor this year, Endo
Pharmaceuticals, and I’m hopeful that there are
other organizations that will be willing to help
                                                     3
        Continuing Education Course                         Morphology and Endocrinology of the
                                                             Female Reproductive Tract in Rodents,
AM6 Basic (8:15 a.m.-noon): Understanding                    Pamela E. Blackshear, Integrated
Lifespan Changes in Form and Function of                     Laboratory Systems, Inc., Research
the Female Reproductive System to Assess                     Triangle Park, NC.
and Interpret Toxicity                                      Morphology and Endocrinology of the
Chairpersons: Barbara J. Davis, NIEHS,                       Female Reproductive Tract in
Research Triangle Park, NC and Kimberley A.                  Nonhuman Primates, J. Mark Cline,
Treinen, Schering Plough Research Institute,                 Wake Forest University School of
Lafayette, NJ.                                               Medicine, Winston-Salem, NC.
This course reviews the basic morphology and                Interpreting Female Reproductive
endocrinology of the female reproductive                     Toxicity Data, Patrick J. Wier,
system in rodents and primates as a basis for                GlaxoSmithKline, King of Prussia, PA.
interpreting toxicity. Each of the 4 lectures will
emphasize fundamental changes and                                          Roundtable
vulnerabilities of the reproductive tract over the
lifespan of the female. Both rodent and non-             Contribution of Neurobehavioral Assessment of
human primates will be discussed with respect            Offspring to Hazard Identification and
to relevance to humans. The first lecture covers         Characterization (Tuesday, 8:30-11:30 a.m.)
embryological development of the female                  (cosponsor = Neurotoxicology)
reproductive system and will include key
developmental and molecular events with an                   Neurobehavioral Assessment:     A survey of
emphasis on timing of events in rodents and                   use and value in safety assessment studies,
primates and potential periods of susceptibility              Larry D. Middaugh, Medical University of
to toxicity. The second lecture details the                   South Carolina, Charleston, SC.
morphology and endocrinology of the female
reproductive tract in rodents and will relate
                                                             A retrospective analysis of developmental
                                                              neurotoxicity studies submitted to the
hormones and histology of the adult rodent
                                                              USEPA, Susan L. Makris, USEPA,
reproductive tract from the onset of puberty to
                                                              Washington, DC.
reproductive senescence and important sites of
toxicity. The third lecture details the                      Behavioral test methods workshop,
morphology and endocrinology of the female                    William Slikker, Jr., National Center for
reproductive tract in nonhuman primates with                  Toxicological Research, Jefferson, AR.
emphasis on similarities and differences to                                 Symposia
rodents. The final lecture will combine the
information of the first lectures and analyze            Steroid Inactivation: Alternative Mechanisms of
issues of study design, endpoints to examine             Endocrine Toxicity (Monday, 9:30 a.m.-noon)
and interpretation of results in assessing female        (cosponsors = Mechanisms and Molecular
reproductive toxicity data.                              Biology)
                                                              Xenobiotic interference with hormone
    Embryological Development of the                           transport processes, Gerald A. LeBlanc,
        Female Reproductive System, Philip                      North Carolina State University, Raleigh,
        M. Iannaccone, Northwestern                             NC.
        University Feinberg School of                         The nuclear receptor CAR in regulation of
        Medicine and Children's Memorial                        estrogen metabolism, Masahiko Negishi,
        Institute for Education and Research,                   NIEHS, Research Triangle Park, NC.
        Chicago, IL.
                                                  4

    Molecular regulation of hepatic                      Proinflammatory mechanisms of PCB
     sulfotransferases, Melissa Runge-                     toxicity in the vascular endothelium,
     Morris, Wayne State University,                       Bernhard Hennig, University of Kentucky,
     Detroit, MI.                                          Lexington, KY.
    Nuclear receptor PXR- and CAR-                       Expression profiles of cultured vascular
     mediated induction of steroid                         smooth muscle cells and aorta are widely
     biotransformation enzymes and                         different, but show common responses to
     relationship with reproductive                        dioxin exposure, Alvaro Puga, University
     development, Li You, CIIT Centers for                 of Cincinnati, Cincinnati, OH.
     Health Research, Research Triangle                   Cardiovascular changes following chronic
     Park, NC.                                             rodent exposure to dioxin-like compounds,
                                                           Michael P. Jokinen, Pathology Associates
Systems Biology: a new venue for exploring
                                                           – A Charles River Company, Durham, NC.
mechanisms of developmental toxicity
(Monday, 1:30-4:30 p.m.)                                                 Workshops
    Systems biology top down, Eric
      Werner, Cellnomica, Inc., Fort Myers,           Hormone Replacement Therapy: A Challenge of
      FL.                                             Risks and Benefits (Wednesday, 1:30-4:30 p.m.)
                                                      (cosponsored with Women in Toxicology,
    A gene regulatory network for                    Regulatory and Safety Evaluation, and Risk
      development, Gabriele Amore,
                                                      Assessment)
      California Institute of Technology,
      Pasedena, CA.                                        Hormone therapy in menopause: the
                                                             clinical context, Anthony R. Scialli,
    Challenges and opportunities in                         Georgetown University Hospital,
      utilizing systsems biology approaches                  Washington, DC.
      for informing developmental
      toxicology, Elaine M. Faustman,                      Alternatives to hormone therapy, Adriane
      University of Washington, Seattle, WA.                 Fugh-Berman, George Washington School
                                                             of Medicine, Washington, DC.
    Computational modeling of cell
      signaling pathways: A step on the road               Results and predictability of animal studies
      to improved characterization of dose-                  for human risk, Alexander Jordan,
      and time-response for the adverse                      USFDA, Rockville, MD.
      effects of toxicants, Rory Conolly, CIIT             Testosterone and aging: Clinical research
      Centers for Health Research, Research                  directions; Institute of Medicine Report on
      Triangle Park, NC.                                     Testosterone Therapy in Older Men, E.
                                                             Darracott Vaughan, Cornell University,
Mechanisms of Cardiovascular Toxicity by
                                                             New York, NY.
2,3,7,8-Tetrachlorodibenzo-p-dioxin and
Related Halogenated Aromatic Hydrocarbons             Zebrafish-A Model Organism for Assessing
(Tuesday, 8:30-11:30 a.m.)                            Developmental Toxicity in Drug
(cosponsored with Mechanisms)                         Discovery/Environmental Risk Assessment
     TCDD cardiotoxicity in developing               (Wednesday, 8:30-11:30 a.m.)
        zebrafish, Warren Heideman,                   (cosponsors = In Vitro, Neurotoxicology, and
        University of Wisconsin, Madison, WI.         Regulatory and Safety Evaluation)
     Fetal dioxin exposure inhibits coronary              Transgenesis, microarray analysis, and
        vasculogenesis. A potential risk factor              anti-sense knockdowns of zebrafish
        for ischemic heart disease?, Mary K.                 genes—tools for using zebrafish as a
        Walker, University of New Mexico,                    toxicological model, Elwood Linney, Duke
        Albuquerque, NM.                                     University Medical Center, Durham, NC.
                                                 5

    Zebrafish and dioxin developmental                       RDTSS ANNUAL MEETING
     toxicity: Poised to identify critical
     genes for specific endpoints, Richard E.        The annual RDTSS meeting is scheduled for
     Peterson, University of Wisconsin,              Tuesday, March 23, from 6:00 to 7:30 p.m. in
     Madison, WI.                                    Room 325 of the Convention Center. Don’t miss
                                                     this opportunity to network with other members
    Nicotine-induced developmental                  and to play a role in the affairs and progress of our
     toxicity in zebrafish, Robert L.
                                                     specialty section. And be sure to bring your
     Tanguay, Oregan State University,
                                                     students, as a special program will be aimed at
     Corvallis, OR.
                                                     them.
    Zebrafish as a model for small molecule
     screening/discovery, Randall T.                  Program Ideas for the 2005 SOT Meeting
     Peterson, Massachusetts General
     Hospital, Charlestown, MA.                      Now is the time to start gathering RDTSS ideas
    Evaluating the toxicity of                      for Symposia, Workshops, Roundtables, and
     environmental samples using zebrafish           Continuing Education courses for the 2005
     developmental endpoints and alteration          meeting. We will need to have these ready in
     of gene expression, Michael J. Carvan,          April, so let's be ready with some ideas before the
     University of Wisconsin-Milwaukee,              meeting in March. Be expecting an e-mail from
     Milwaukee, WI.                                  me in the next week soliciting your ideas. These
                                                     can be anything from a topic or title to better
The National Children's Study: Progress              fleshed-out ideas with potential cosponsors,
developing methods appropriate for assessing         speakers, talk titles, etc. So please respond to the
children's exposure, biomarkers, and genetic         e-mail with at least one idea! I already have been
susceptibility (Thursday, 8:30-11:30 a.m.)           contacted by the Inhalation Toxicology Specialty
(cosponsor = Neurotoxicology)                        Section with the idea of co-sponsoring a session
     An overview of the National Children’s         on in utero effects on lung function. If you read
       Study, Pauline Mendola, USEPA,                this before getting my e-mail, you can respond
       Research Triangle Park, NC.                   immediately to rogers.john@epa.gov.
     Validation of non-invasive biological
       samples: Pilot projects relevant to the         PROPOSED CHANGES TO
       National Children’s Study, Jane E.
       Gallagher, USEPA, Research Triangle                 THE BYLAWS
       Park, NC.
     Development and use of biomarkers of           The following changes (underlined or struck out)
       exposure for CDC’s National Exposure          are proposed as amendments to the Bylaws for the
       Report, Larry L. Needham, Centers for         SOT Reproductive and Developmental
       Disease Control and Prevention,               Toxicology Specialty Section. These will be
       Atlanta, GA.                                  discussed at the Specialty Section meeting on
                                                     Tuesday, March 23, 2004, modified as
     Study design considerations for the            appropriate, and voted on by email ballot. Please
       Exposure component of the National
                                                     review these prior to the RDTSS meeting.
       Children’s Study, Haluk Ozkaynak,
       USEPA, Washington, DC.
                                                                   29th November 2001
     Environmental exposure and asthma:                      Amended 3rd February 2004
       Hypotheses for the National Children’s                     Society of Toxicology
       Study, Stephanie J. London, NIEHS,              Reproductive and Developmental Toxicology
       Research Triangle Park, NC.                                  Specialty Section
                                                                         Bylaws
                                                     6
                                                         Section shall be the chairperson of the Executive
       ARTICLE IV – OFFICERS AND                         Committee. Four members of the Executive
             COUNCILLORS                                 Committee shall constitute a quorum for the
                                                         transaction of business.
The RDT Specialty Section Officers shall be
President, Vice President, Vice President-Elect,         Section 4.A. The President of the Specialty
and Secretary-Treasurer. There shall be three            Section, together with the Past President, shall
five Councillors, including two student                  provide an annual reports of their activities and
councilors. The Vice President-Elect shall be            finances for the currentprevious year as well as
elected annually and the Secretary-Treasurer             plans of programs, activities and finances for the
biannually by the Specialty Section members.             following year. Annual reports shall be submitted
They shall serve until their successors are              to the SOT Director by August 31 of each year.
installed. Officers and Councillors shall take
office on May 1.                                                      ARTICLE VIII – DUES

  ARTICLE V – ELECTION OF OFFICERS                       Dues will be established by a majority of the
         AND COUNCILLORS                                 Executive Committee after which they may be
                                                         changed, subject to vote by members of the
Section 5. There shall be three five                     sectionthe Society of Toxicology Council.
Councillors, who, together with the officers,
will comprise the Executive Committee. Two                        ARTICLE IX – COMMITTEES
Councilors shall be student members. The first
year after these by-laws are approved, one               Section 1. The Vice President shall be
student member shall be elected for one year,            Chairperson of the Program Committee whose
and one for two years. Thereafter, a student             members appointed by the Chairpersonand will
member shall be elected each year for two                select 2-3 members to serve on the Committee.
years. One full member shall be elected each             The Program Committee shall develop solicit and
year for two years. The immediate Past                   review scientific and educational programs
President shall be the thirdfifth Councillor.shall       proposals consistent with the objectives of the
be the immediate Past President.                         RDT Specialty Section, and provide copies of the
                                                         material to the Secretary-Treasurer who will, in
Section 6. A Nominating Committee                        turn, notify Council of SOT prior to developing
consisting of not less than three members shall          the program. Proposals deemed appropriate for
be appointed by the Executive Committee of               sponsorship or co-sponsorship by RDTSS will be
the Specialty Section (i.e., the officers plus           recommended to the Executive Committee.
Councillors), within two months following                Proposals approved for sponsorship will be
installation of officers. The Committee shall            indicated to the SOT Program Committee. The
provide a slate of candidates for each election.         RDTSS Program Committee shall coordinate its
                                                         activities with the SOT Program Committee and
Section 7. Elections shall be held annually by           with other appropriate Specialty Sections.
mail or e-mail ballot. Ballots will be mailed or
e-mailed by the SOT and the any costs will be                     ARTICLE X – AMENDMENTS
charged to the RDT Specialty Section.
                                                         Section 1. Amendments to these Bylaws may be
     ARTICLE VI – ADMINISTRATION                         presented by any member of the Specialty Section
                                                         in good standing at any regular meeting of the
Section 2. The Executive Committee shall                 Section or at any special meeting called for that
consist of the four two elected officers plus the        specific purpose for discussion by those present at
threefive Councillors. The President of the              the meeting. TheyAmendments shall then be
                                                      7
presented in writingcirculated by e-mailand
shall be offered to the membership present at
that meeting on motion for consideration and
circulation to the membership. A simple
majority shall be necessary to pass the motion.

Amendments accepted for future consideration
and circulation shall be printed and circulated
with a ballot to all members in good standing.
A two-thirds affirmative vote of the ballots
returned within 30 days shall be necessary for
adoption of any amendment.                                   ENCOURAGE YOUR STUDENTS
                                                                  TO JOIN RDTSS
         A TIP FROM EDITOR RON
                                                          Mentors of graduate students, please encourage
Have you ever been puzzled, as I have, about              them to join our specialty section. Our students
the preferred spelling of a technical (or other)          and postdocs are the future of the RDTSS.
term, especially one that may be too new to
appear in any of the technical/medical                          2002-2003 RDTSS OFFICER
dictionaries you may have on hand? Solving
the puzzle is easy. Just enter one of the                       CONTACT INFORMATION
possible spellings in the search engine Google            President
and note the total number of ―hits.‖ Then do              Carole A. Kimmel
the same for any alternate spellings. A count of          US EPA
the total number of hits will be shown on the             National Center for Environmental Assessment
right end of a solid blue bar spanning the first          (8623-D)
results page of each search. Usually one of the           Ariel Rios Building
alternatives has many more hits than the                  1200 Pennsylvania Ave., N.W.
other(s), thus indicating the preferred usage! In         Washington, DC 20460
fact if you have entered a common misspelling             TEL: (202) 564-3307
on your search, Google may even ask, ―did you             FAX: (202) 565-0078
mean: XXX?‖ where ―XXX‖ is the correct                    E-mail:
spelling. For example, I tried deliberately               kimmel.carole@epa.gov
misspelling ―proteomics‖ as ―protomics,‖ as a
test case, and easily elicited the correct spelling
from Google.                                              Vice President
                                                          John Rogers
            CALL FOR NEWS                                 USEPA
                                                          Reproductive Toxicology Division
Please send any newsworthy items to the                   MD 67
RDTSS Newsletter Editor, Ron Hood, at the                 Research Triangle Park, NC 27711
address listed on the cover page. E-mail is the           TEL: (919) 541-5177
preferred way to send news, either in the body            FAX: (919) 541-4017
of the message or as an attachment. Also,                 E-mail: rogers.john@epa.gov
please be sure to describe the purpose of your
message in the subject line of your e-mail so I
won’t assume it is just more spam and delete it           Vice President-elect
without ever opening it!                                  Dana L. Shuey
                                                          Endo Pharmaceuticals, Inc.
                                       8
Preclinical Safety Assessment              Senior Councilor
100 Painters Drive                         Barbara Abbott
Chadds Ford, PA 19317                      USEPA
TEL: (610) 558-9800                        NHEERL Reproductive Toxicology Division
FAX: (610) 387-4094                        MD 67
E-mail: shuey.dana@Endo.com                Research Triangle Park, NC 27711
                                           TEL: (919) 541-2753
Secretary/Treasurer                        FAX: (919) 541-4017
Philip Mirkes                              E-mail: Abbott.Barbara@epamail.epa.gov
University of Washington
Department of Pediatrics                   Freshman Councilor
1959 NE Pacific Street                     Kim Boekelheide
PO Box 356320                              Brown University
Seattle, WA 98195                          Department of Pathology & Laboratory Medicine
TEL: (206) 543-3373                        171 Meeting Street
FAX: (206) 543-3184                        P O Box G B587
E-mail: pemst@u.washington.edu             Providence, RI 02912
                                           TEL: (401) 863-1783
Past President                             FAX: (401) 863-9008
Kimberley A. Treinen                       E-mail: kim_boekelheide@brown.edu
Schering-Plough Research Institute
PO Box 32
144 Route 94
Lafayette, NJ 07848-0032
TEL: (973) 940-4327
FAX: (973) 940-4509
E-mail: kimberley.treinen@spcorp.com

								
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