HORMONE

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HORMONE Powered By Docstoc
					HORMONE       TYPE      SECRETOR     EFFECTOR             ACTION          ACTIVATOR      INHIBITOR               DISEASES

                                                    1. Vascular SM
                                          1.
                                                    contraction
Vasopressin                          Vasculature
                                                    2. H2O retention by
              peptide    post. pit    2. Kidney
                                                    kidney
                                                    1. SM contraction
 Oxytocin
                                                    in uterus & breast
                                                    stim T3 & T4
   TSH                                 Thyroid                               TRH
                                                    production
                                                    stim cortisol &
  ACTH                               Adrenal Ctx    adrenal androgens        CRH
                                                    (DHA)
                                                    1. Gamete
                                                                                        1. androgens
                                      1. Gonads     production
                                                                                         2. estrogen
   FSH                               2. granulosa   2. stimulates            GnRH
                                                                                              3.
                                         cells      aromatase 
                                                                                        progestertone
                                                    estradiol secretion
                                                    1. Sex hormone
                                                    secretion
                                                    2. induces
                                                                                        1. androgens
                                                    ovulation
                                                                                         2. estrogen
    LH        peptide    ant. pit      Gonads       3. induces               GnRH
                                                                                              3.
                                                    luteinization
                                                                                        progestertone
                                                    4. lack of causes
                                                    degradation of the
                                                    corpus luteum
                                                    growth & milk
 Prolactin                             Breast                                PRH            PIH
                                                    ejection
                                                    stim growth                                         Acromegaly: ↑ in adult: ↑
                                                                                                        bone and soft tissue
                                                                                 1.                     Pituitary Giganticism: ↑ in
                                                                                             1.
                                     All sorts of                         Somatomedin                   development: big proportional
    GH                                                                                  Somatostatin
                                       places                                 (liver)                   adult
                                                                                          2. GHIH
                                                                            2. GHRH                     Pituitary Dawfism: ↓ in
                                                                                                        development: small but no
                                                                                                        intellectual retardation
                                                    ↑ glc taken up into                                 Diabetes 1:
                                                    the cell                                            β cells not produce insulin
                                                                                                        Diabetes 2:
                                     All sorts of                                                       insulin insensitivity
  Insulin     peptide       β
                                       places
                                                                                                        uncontrolled both can 
                                                                                                           met acidosis  coma
                                                                                                           acetyl CoA accumulation
      HORMONE            TYPE      SECRETOR       EFFECTOR             ACTION          ACTIVATOR      INHIBITOR             DISEASES

                                                                                                                        the formation of keto-
                                                                                                                       acids
                                                                 1. ↓ glc taken up
                                                                 into the cell
       Glucagon                         α
                                                                 2. ↑
                                                                 gluconeogenesis
                                                                 1. inhibits all
                                                                 pancreatic
                                                                 secretions  delay
     Somatostatin                       δ                        absorption &
                                                                 metabolism
                                                                 2. inhibits GH
                                                                 release
                                                                 1. ↑ Na resorption                                Hyperaldoseronism: ↑
                                                                 and H2O retention                                 1º: adenoma
                                                   Kidney:                               Renin-
                                                                 2. ↓ K and H                          Atrial      2º: excessive renin
      Aldosterone                                  distal &                            Angiontensin
                                   glomerulosa                                                        Naturietic   production
  (Mineralocorticoids)                             collectin                            system: ↑
                                                                                                      Hormone           ↑ BP
                                                   tubules                             Angiotensin
                                                                                                                        low [K] in blood
                                                                                                                        weakness
                                                                 1. ↑ glycogen                                     Cushing Syndrome: ↑
                                                                 formation                                         1º: adenoma of adrenal ctx
                                                                 2. ↓ muscle mass                                  2º: excessive ACTH
                                                                  protein                                         stimulation
                                                                 mobilization                                           moonface
                                                                 3. Fat mobilization                                    buffalo hump
                                                                 4. ↓ lymphocytes &                                     abnormal sex related
        Cortisol                                  All sorts of   eosinophils                                            functions
                         steroid    faciculata                                            ACTH         Cortisol
   (glucocorticoids)                                places       5. ↓ bone formation                                    loss of skin elasticity
                                                                 ↑ bone resorption                                 Addison’s: ↓
                                                                                                                   1º or 2º to lack of pituitary
                                                                                                                   stim
                                                                                                                        weakness
                                                                                                                        hypotension
                                                                                                                        weight loss
                                                                                                                        skin pigmentation
                                                                 Accessory to the                                  Adreno-Genital Syndrome: ↑
                                                                 sex hormones                                      congenital defect of specific
                                                                 secreted by the                                   adrenal ctx enzymes ↑ the
Dehydroepiandrosterone
                                    reticularis                  gonads                   ACTH         Cortisol    production of androgens
 (Adrenal Androgens)
                                                                                                                          masculine 2º sex
                                                                                                                          characteristics
                                                                                                                   Virilization: ↑
   HORMONE            TYPE       SECRETOR           EFFECTOR             ACTION         ACTIVATOR          INHIBITOR                 DISEASES

                                                                                                                            enzymes to make cortisol are
                                                                                                                            absent so inhibition of the hyp
                                                                                                                            and ant pit does not occur –
                                                                                                                            devlopment of male 2º sex
                                                                                                                            characteristics
                                                                                                                            Addison’s: ↓
                                                                                                                            1º or 2º to lack of pituitary
                                                                                                                            stim
                                                                                                                                 weakness
                                                                                                                                 hypotension
                                                                                                                                 weight loss
                                                                                                                                skin pigmentation
                                                                   1. ↑ metabolic                                           Hypothyroidism: coma?
                                                                   activity                                                 Birth: cretinism – dwarfism
                                                                   2. ↑ proteins for                                        with low intelligence
                                                                   growth &                                                 Adult: due to fibrotic
                                                                   maturation                                               destruction of the thyroid
                                                                   3. ↑ respiratory                                          T3/T4       TSH        Goiter
                                                                   enzymes                                                   1º thyroid failure
                                                                   4. ↑ Na/K ATPase                                          ↓           ↑          yes
                                                                                                                             2º to hypothalamic or ant
                                                                                                                             pit failure
                                                                                                                             ↓           ↓          no
 Triiodotyrosine                 thyroid follicle   All sorts of                                                             lack of dietary I-
                     peptide                                                            TRH  TSH                            ↓           ↑          yes
Tetraiodotyrosine                     cells             cells

                                                                                                                            Hyperthyroidism:
                                                                                                                              T3/T4      TSH     Goiter
                                                                                                                              Graves: ↑ TSI
                                                                                                                              ↑          ↓       yes
                                                                                                                              2º to excessive hyp or ant
                                                                                                                              pit secretion
                                                                                                                              ↑          ↑       yes
                                                                                                                              hypersecreting thyroid
                                                                                                                              tumor
                                                                                                                              ↑          ↓       no
                                                                   ↑ Ca absorption in                                       Rickets:
                                                                   the intestine                                            in children – bone
                                                                                                                            malformation and low density
   Vitamin D         steroid                         intestine
                                                                                                                            Osteomalacia:
                                                                                                                            in adults – bone malformation
                                                                                                                            and low density
      PTH           polypetide     chief cells                     1. activates         ↓ [Ca] in blood   ↑ [Ca] in blood   Carpel-Pedal Syndrome: ↓
 HORMONE         TYPE        SECRETOR           EFFECTOR            ACTION          ACTIVATOR         INHIBITOR            DISEASES

                                                              osteoclasts                                         hypocalcemia
                                                              2. ↑ Ca absorption                                      tetanic contractions in
                                                              in the kidney but                                       hands and feet
                                                              not PO4                                             Spont. nerve excitation: ↓
                                                              3. promoted Vit D                                   hypocalcemia
                                                              activation in the                                   Osteolysis: ↑
                                                              kidney                                                  bone lesions because of
                                                                                                                      excessive solubilization
                                                                                                                      of CaPO4 crystals
                                                              1. inhibits
                             parafollicular
 Calcitonin    polypeptide                                    osteolysis by ↓       ↑ [Ca] in blood
                                 cells
                                                              CaPO4 solubility
  LH/FSH       see above       see above         see above    see above               see above       see above            see above
                             thecal cells of   1. granulosa   1. converted to
                             the follicle      cells          estrogen in
 Androgen
                                               2. target      granulosa cells
                                               tissues        2. masculinization
                             1. granulosa      3. target      1. inducesthe
                             cells             tissues        proliferative phase
                             2. corpus                        of endometrium
 Estrogen                    luteum                           2. lack causes
                 steroid                                      necrosis of
                                                              endometrium
                                                              3. feminization
                             granulosa                        1. induces the
                             cells of the                     secretory phase of
                             corpus                           endometrium
Progesterone
                             luteum                           2. lack of causes
                                                              necrosis of the
                                                              endometrium

				
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posted:11/21/2011
language:English
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