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Circulating Tumor Cells

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posted:
11/19/2011
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Preprocessing Techniques for

Image Analysis Applications

Hong Zhang

Preprocessing

• High dimensionality

• Limited sample size

• A simple argument: Rao-Blackwell

Preprocessing

• Normalization / transformation

• Feature extraction / elimination

• Kernel design

Medical Imaging Applications







image Image Feature Kernel SVM

Processing Extraction Design

Mammography

Mathematical Morphology

• Erosion • Tophat

• Dilation • Watershed

• Opening • Reconstruction

• Closing • Skeletonization

Calcification Detection

Cell Image

Segmentation

Simple Features

• Area • Mean

• Length • Variance

• Elongation • Density

• Eccentricity • Fractal dimension

• Compactness • Moments

Kernel Invariance

Translation Invariance

Rotation Invariance

The Fourier Kernel







translation







rotation

3D Problems

• Harmonic analysis on locally compact

Abelian group



• S2 is not a topological group

• SO(3) is not Abelian

• Torus

• Quaternion

Circulating Tumor Cells

Automatic CTC Detection

Canonical Correlation Analysis



Maximize correlation









Functional MRI

Flow Cytometry

Distance Measures

• Bhattacharyya affinity

• Nearest neighbor error

• Mahalanobis distance

• Kullback-Leibler divergence

• Jeffreys’ divergence

Kernel on Distributions

Clustering

• Gaussian mixture

• K-means

• EM algorithm

• Regularization



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