Additional file 3. 106 immune response-related genes
Chemokine receptors Itk-/- vs Wt t-test
Probe set Gene title
1419610_at chemokine (C-C motif) receptor 1 2.62 0.000
1421186_at chemokine (C-C motif) receptor 2 2.09 0.011
1421188_at chemokine (C-C motif) receptor 2 2.69 0.000
1422957_at chemokine (C-C motif) receptor 3 2.32 0.090
1424727_at chemokine (C-C motif) receptor 5 2.81 0.009
1456887_at Chemokine-like receptor 1 2.17 0.072
Chemokines
1419426_s_at chemokine (C-C motif) ligand 21b /// chemokine (C-C motif) ligand 21a /// chemokine (C-C motif) ligand 21c (leucine) -2.59 0.443
1419561_at chemokine (C-C motif) ligand 3 3.18 0.088
1421578_at chemokine (C-C motif) ligand 4 3.04 0.071
1417266_at chemokine (C-C motif) ligand 6 2.64 0.019
1420249_s_at chemokine (C-C motif) ligand 6 3.12 0.040
1417936_at chemokine (C-C motif) ligand 9 2.01 0.013
1449984_at chemokine (C-X-C motif) ligand 2 2.55 0.253
1448995_at chemokine (C-X-C motif) ligand 4 2.14 0.059
1418480_at chemokine (C-X-C motif) ligand 7 3.69 0.016
Colony stimulating factor receptors
1423593_a_at colony stimulating factor 1 receptor 2.95 0.145
1419873_s_at colony stimulating factor 1 receptor 3.96 0.095
1420703_at colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 2.44 0.007
1455660_at Colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage) 2.64 0.016
1449360_at colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 2.51 0.042
Fc receptors
1418340_at Fc receptor, IgE, high affinity I, gamma polypeptide 3.76 0.016
1422122_at Fc receptor, IgE, low affinity II, alpha polypeptide 2.62 0.295
1416978_at Fc receptor, IgG, alpha chain transporter 3.61 0.002
1451941_a_at Fc receptor, IgG, low affinity IIb 2.65 0.021
1448620_at Fc receptor, IgG, low affinity III 2.69 0.034
Granzymes
1417898_a_at granzyme A 2.53 0.025
1420343_at granzyme D -5.68 0.138
1420344_x_at granzyme D -2.31 0.462
1450171_x_at granzyme E 2.43 0.333
1449501_a_at granzyme M (lymphocyte met-ase 1) 6.39 0.013
Interferon-related genes
1419603_at interferon activated gene 204 /// myeloid cell nuclear differentiation antigen 2.53 0.126
1425947_at interferon gamma 2.24 0.009
1458589_at Interferon gamma induced GTPase -2.28 0.462
Interleukin receptors
1448950_at interleukin 1 receptor, type I -2 0.501
1420678_a_at interleukin 17 receptor B 2.34 0.026
1421291_at interleukin 18 receptor accessory protein 2.58 0.000
1443937_at Interleukin 2 receptor, beta chain 2.06 0.006
1448759_at interleukin 2 receptor, beta chain 2.14 0.015
Interleukins
1417932_at interleukin 18 3.17 0.087
1450334_at interleukin 21 2.17 0.102
1449864_at interleukin 4 2.77 0.013
1450297_at interleukin 6 2.59 0.020
Intracellular signaling components
1451780_at B-cell linker 2.25 0.001
1457120_at IL2-inducible T-cell kinase -3 0.096
1418261_at spleen tyrosine kinase 2.87 0.012
1449455_at hemopoietic cell kinase 3.21 0.042
1438921_at Ataxia telangiectasia and rad3 related 3.44 0.205
1456328_at B-cell scaffold protein with ankyrin repeats 1 2.59 0.007
1425714_a_at Nfat activating molecule with ITAM motif 1 2.16 0.029
Killer cell lectin-like receptors
1458642_at killer cell lectin-like receptor family E member 1 2.6 0.000
1451664_x_at 2.13 0.013
killer cell lectin-like receptor subfamily A, member 12 /// killer cell lectin-like receptor, subfamily A, member 4 /// killer cell lectin-like receptor, subfamily A, member 7 /// killer cell lectin-like receptor subfamily A, member 20 /// killer cell lectin-like rec
1422065_at killer cell lectin-like receptor subfamily B member 1D 3.16 0.020
1425005_at killer cell lectin-like receptor subfamily C, member 1 /// killer cell lectin-like receptor subfamily C, member 2 2.13 0.026
1420790_x_at killer cell lectin-like receptor, subfamily A, member 16 -2.62 0.343
1426127_x_at killer cell lectin-like receptor, subfamily A, member 18 2.99 0.023
1426140_x_at killer cell lectin-like receptor, subfamily A, member 19 2.73 0.020
1425436_x_at killer cell lectin-like receptor, subfamily A, member 3 9.92 0.000
1420789_at killer cell lectin-like receptor, subfamily A, member 5 4.22 0.017
1426171_x_at killer cell lectin-like receptor, subfamily A, member 7 4.14 0.002
1425417_x_at killer cell lectin-like receptor, subfamily A, member 8 35.69 0.000
Miscellaneous
1448471_a_at cytotoxic T lymphocyte-associated protein 2 alpha 3.03 0.000
1416811_s_at cytotoxic T lymphocyte-associated protein 2 alpha /// cytotoxic T lymphocyte-associated protein 2 beta 2.81 0.002
1452352_at cytotoxic T lymphocyte-associated protein 2 beta 2.68 0.003
1421802_at eosinophil-associated, ribonuclease A family, member 1 2.33 0.043
1422411_s_at 2.97 ribonuclease A family, member 3 /// eosinophil-associated, ribonuclease A family, member 12
eosinophil-associated, ribonuclease A family, member 1 /// eosinophil-associated, ribonuclease A family, member 2 /// eosinophil-associated,0.011
1449846_at eosinophil-associated, ribonuclease A family, member 2 2.57 0.001
1422412_x_at eosinophil-associated, ribonuclease A family, member 3 3.64 0.036
1417337_at erythrocyte protein band 4.2 2.25 0.003
1418636_at ets variant gene 3 -2.01 0.546
1429889_at Fas apoptotic inhibitory molecule 3 2.75 0.131
1447736_at FK506 binding protein 5 -2.77 0.148
1418204_s_at allograft inflammatory factor 1 2.28 0.188
1452016_at arachidonate 5-lipoxygenase activating protein 2.48 0.021
1439660_at human immunodeficiency virus type I enhancer binding protein 3 -2.58 0.528
1425519_a_at Ia-associated invariant chain 2.26 0.004
1460423_x_at Ig kappa chain 2.09 0.013
1415855_at kit ligand 2.45 0.126
1425548_a_at leukocyte specific transcript 1 2.03 0.079
1422903_at lymphocyte antigen 86 3.39 0.003
1438687_at lymphocyte transmembrane adaptor 1 2.22 0.006
1427076_at macrophage expressed gene 1 3.95 0.055
1428167_a_at myelin protein zero-like 1 4.37 0.192
1419772_at Myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog (Drosophila) -2.49 0.403
1439389_s_at myeloid-associated differentiation marker 2.03 0.066
1423321_at myeloid-associated differentiation marker 2.1 0.042
1455318_at T-cell immunoglobulin and mucin domain containing 4 3.63 0.135
1418545_at WASP family 1 -3.01 0.016
CD surface antigens
1417268_at CD14 antigen 2.1 0.205
1419144_at CD163 antigen 6.73 0.127
1421547_at CD180 antigen 2 0.007
1450570_a_at CD19 antigen 2.8 0.157
1419769_at CD22 antigen 2.82 0.068
1419768_at CD22 antigen 3.6 0.054
1416034_at CD24a antigen 2.49 0.016
1427994_at CD300 antigen like family member F 2.19 0.016
1435903_at CD300A antigen 3.97 0.114
1448919_at CD302 antigen 3.3 0.015
1423166_at CD36 antigen 3.12 0.017
1433741_at CD38 antigen 2.4 0.012
1423760_at CD44 antigen 2.37 0.095
1458634_at CD47 antigen (Rh-related antigen, integrin-associated signal transducer) -2.04 0.478
1449193_at CD5 antigen-like 4.2 0.103
1449164_at CD68 antigen 4.53 0.087
1418830_at CD79A antigen (immunoglobulin-associated alpha) 2.76 0.160
1417640_at CD79B antigen 2.32 0.082
Toll-like receptors
1418162_at toll-like receptor 4 4.19 0.109
1422083_at toll-like receptor 9 -2.15 0.474
Transcription factors
1421303_at IKAROS family zinc finger 1 -2.2 0.259
1422537_a_at inhibitor of DNA binding 2 2.03 0.012
1460407_at Spi-B transcription factor (Spi-1/PU.1 related) 2.38 0.138
1419874_x_at zinc finger and BTB domain containing 16 5.46 0.005
1416916_at E74-like factor 3 2.97 0.078
1457441_at early B-cell factor 1 -2.16 0.360
1416301_a_at early B-cell factor 1 2.26 0.102
1435172_at eomesodermin homolog (Xenopus laevis) 2.56 0.000
1426001_at eomesodermin homolog (Xenopus laevis) 3.07 0.004
1429427_s_at transcription factor 7-like 2, T-cell specific, HMG-box 2.41 0.298
1447640_s_at pre B-cell leukemia transcription factor 3 2.05 0.121