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posted:
11/18/2011
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What will I learn during the next six weeks?

Lectures



• Recording and assessing adult & neonatal cardiocyte contractility

• Cardiovascular system; structure of the heart

• The heart as a pump; heart performance; blood pressure

• The heart during exercise; heart disease: risk factors

• Cardiac muscle mechanics

• Genome expression studies using microarrays

• A quick introduction to computer modeling

• Principles of PCR and qPCR

• Medical training vs. doctoral degree training programs and their costs



Basic techniques



Pipetting, balance, pH meter, solution preparation, dilutions



Cellular cardiology – using cardiomyocytes



• Neonatal cardiomyocyte preparation: Cell viability determination

• Gene silencing; western blots; RT-PCR; PCR

• Record and analyze cardiomyocyte contractility

• Record and analyze calcium transient in cardiomyocytes



Microbiology: studies using E. coli



• Prepare LB/earb Plates

• Transform E. coli and plate

• Toothpick Inoculation of E. coli

• Lyse E. coli.: Extract plasmid DNA

• Evaluate DNA concentration

• Plasmid restriction digest



Guest lectures and labs



 Dr. Ricardo Zayas:

Stem cells, tissue regeneration, therapies; Cardiac cell differentiation, myosin-actin assembly



 Dr. Roland Wolkowicz:

Fluorescence-activated cell sorting (FACS); Separating myocardial cells (myocytes, fibroblasts, etc.)





Bridges & Pre-MARC 2011



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