CURRICULUM VITAE
M(ac) Donald Cave
Born: May 14, 1939; Philadelphia, Pennsylvania
Addresses: Home: 5220 Crestwood, Little Rock, AR 72207
Office: Department of Neurobiology and Developmental Sciences, #510
University of Arkansas for Medical Sciences, Little Rock, Arkansas
72205-7199
Education:
1) B.A., Susquehanna University; 1961, Biology
2) M.S., University of Illinois; 1963, Anatomy
3) Ph.D., University of Illinois; 1965, Anatomy
Professional Background:
a) Instructor; Department of Anatomy, University of Illinois; 1964-1965.
b) Postdoctoral Fellow; Genetics Institute, Lund, Sweden; A. Lima-de-Faria, Mentor; 1965-
1966.
c) Postdoctoral Fellow; Max-Planck-Institute, Tubingen, West Germany, W. Beermann,
Mentor; 1966-1967.
d) Assistant Professor; Department of Anatomy, University of Pittsburgh, School of Medicine;
1967-1972.
e) Associate Professor, Department of Anatomy, University of Arkansas School of Medicine;
1972-1979.
f) Professor; Department of Anatomy, University of Arkansas School of Medicine; 1979---.
Publications
Research Articles:
1) Cave, M.D. 1966. Incorporation of tritium-labeled thymidine and lysine into chromosomes
of cultured human leucocytes. J. Cell Biol. 29:209-222.
2) Cave, M.D. 1966. Reverse patterns of thymidine-H3 incorporation in human
chromosomes. Hereditas 54:338-355.
3) Cave, M.D. and J.M. Levitsky 1966. Tritiated thymidine uptake by group G chromosomes
of female individuals with Down's syndrome. Exp. Cell. Res. 43:210-213.
4) Cave, M.D. 1966. Chromosomal H3-lysine incorporation and patterns of deoxyribonucleic
acid synthesis in human cells. Exp. Cell Res. 45:631-637.
5) Cave, M.D. 1968. Chromosome replication and synthesis of non-histone proteins in giant
polytene chromosomes. Chromosoma (Berl.) 25:392-401.
6) Lima-de-Faria, A., B. Nilsson, M.D. Cave, A. Puga and H. Jaworska 1968. Tritium
labeling and cytochemistry of extra DNA in Acheta. Chromosoma (Berl.) 25:1-20
7) Allen, E.R., and M.D. Cave 1968. Formation, transport and storage of ribonucleic acid
containing structures in oocytes of Acheta domesticus (Orthoptera). Z. Zellforsch. 92: 477-
486.
8) Cave, M.D., and E.R. Allen 1969. Synthesis of nucleic acids associated with a DNA
containing body in oocytes of Acheta. Exp. Cell Res. 58:201-212.
M.D. Cave, CV 1 Updated 11/17/11
9) Allen, E.R., and M.D. Cave 1969. Cytochemical and ultrastructural studies of
ribonucleoprotein structures in oocytes of Acheta domesticus. Z. Zellforsch. 101: 63-71.
10) Cave, M.D. and E.R. Allen 1969. Extrachromosomal DNA in early stages of oogenesis in
Acheta domesticus. J. Cell Sci. 4:593-609.
11) Cave, M.D., and E.R. Allen 1971. Synthesis of ribonucleic acids in oocytes of the house
cricket (Acheta domesticus). Z. Zellforsch. 120:309-320.
12) Allen, E.R., and M.D. Cave 1972. Nucleolar organization in oocytes of gryllid crickets:
subfamilies Gryllinae and Nemobiinae. J. Morph. 137: 433-447.
13) Cave, M.D. 1972. Localization of ribosomal genes in oocytes of the house cricket Acheta
domesticus (Orthoptera: Gryllidae). J. Cell Biol. 55:310-321.
14) Cave, M.D. 1973. Synthesis and characterization of amplified DNA in oocytes of the
house cricket, Acheta domesticus (Orthoptera: Gryllidae). Chromosoma (Berl.) 42:1-22.
15) Cave, M.D., and E.R. Allen 1974. Nucleolar DNA in oocytes of crickets: representatives
of the subfamilies Oecanthinae and Gryllotalpina (Orthoptera: Gryllidae). J. Morph.
142:379-394.
16) Cave, M.D. 1975. Absence of ribosomal DNA amplification in the meroistic (telotrophic)
ovary of the large milk-weed bug Oncopeltus fasciatus (Dallas) (Hemiptera: Lygaeidae). J.
Cell Biol. 66:461-469.
17) Cave, M.D. and J.W. Sixbey 1976. Absence of DNA amplification in a meroistic
polytrophic ovary. Exp. Cell Res. 101:23-30.
18) Cave, M.D. 1976. Absence of rDNA amplification in the uninucleolate oocyte of the
cockroach Blattella germanica (Orthoptera: Blattidae). J. Cell Biol. 71:49-58.
19) Cave, M.D. 1978. Absence of ribosomal DNA amplification in the polytrophic ovary of
the giant silkworm moth Antheraea pernyi (Lepidoptera: Saturniidae). Wilhelm Roux's
Archives of Developmental Biology 184:135-142.
20) Casciano, D.A., J.A. Farr, J.W.Oldham, and M.D. Cave, and 1978 . 2-acetylaminofluorene-
induced unscheduled DNA synthesis in hepatocytes isolated from 3-methylcholanthrene
treated rats. 5:173-178.
21) Cave, M.D. 1979 Length heterogeneity of amplified circular rDNA molecules in oocytes
of the house cricket Acheta domesticus (Orthoptera: Gryllidae). Chromosoma (Berl.).
71:15-27.
22) Oldham, J., D. Casciano and M.D. Cave 1980. Comparative induction of unscheduled
DNA synthesis by chemical agents in non-proliferating primary cultures of rat hepatocytes.
Chem-Biol. Interactions 29:303-314.
23) Crawford, J.T., M.D. Cave and J.H. Bates 1981. Characteristics of plasmids from strains
of Mycobacterium avium-intracellulare. Rev. Infect. Dis. 3:949-952.
24) Crawford, J.T., M.D. Cave and J.H. Bates 1981. Evidence for plasmid-mediated
restriction modification in Mycobacterium avium-intracellulare. J. Gen. Microbiol.
127:333-338.
25) Benes, H., J. Ware and M.D. Cave 1985. Analysis of genes for 5S rRNA from the cricket,
Acheta domesticus: two classes of repeating units. Gene 36:113-122.
26) Benes, H. and M.D. Cave 1985. Distribution of 5S ribosomal RNA genes in somatic and
germ cells of the house cricket, Acheta domesticus. Chromosoma (Berl.) 93:31-37.
27) Sharp, Z.D., A. Meriwether, J. Ware, and M.D. Cave 1986. Analysis of a large
nontranscribed spacer in the ribosomal DNA of the house cricket, Acheta domesticus
(Orthoptera: Gryllidae). Biochem. Genetics 24:911-923.
28) Cave, M.D., H. Benes, and C. Liarakos 1987. Nucleotide sequence of two repeating units
of the 5S rRNA gene from the house cricket, Acheta domesticus. Gene 51:287-289.
M.D. Cave, CV 2 Updated 11/17/11
29) Ware, J.L., Z.D. Sharp and M.D. Cave 1987. The ribosomal DNA transcription unit of the
house cricket, Acheta domesticus. Biochem. Genetics 25:345-358.
30) Thierry, D., M.D. Cave, K.D. Eisenach, J.C. Crawford, J.H. Bates, B. Gicquel and J.L.
Guesdon 1990. IS6110, an IS-like element of the Mycobacterium tuberculosis complex.
Nuc. Acid Res. 18:188.
31) Eisenach, K.D., M.D. Cave, J.H. Bates and J.T. Crawford 1990. Polymerase chain
reaction amplification of a repetitive DNA sequence for Mycobacterium tuberculosis. J.
Infect. Dis. 161:977-981.
32) Cave, M.D., K.D. Eisenach, P.F. McDermott, J.H. Bates and J.T. Crawford 1990. IS6110:
Conservation of sequence in the Mycobacterium tuberculosis complex and its use in DNA
fingerprinting. Molecular & Cellular Probes 5:73-80.
33) Eisenach, K.D., M.D. Sifford, M.D. Cave, J.H. Bates and J.T. Crawford 1991. Detection
of Mycobacterium tuberculosis in sputum samples using a polymerase chain reaction.
Amer. Rev. Resp. Dis. 144:1160-1163.
34) Mazurek, C.H., M.D. Cave, K.D. Eisenach, R.J. Wallace, J.H. Bates and J.T. Crawford
1991. Chromosomal DNA fingerprint patterns produced with IS6110 as a strain specific
marker for the epidemiologic study of tuberculosis. J. Clin. Microbiol. 29:2030-2033.
35) Cave, M.D., K.D. Eisenach, M. Salfinger, J.H. Bates and J.T. Crawford 1992. Usefulness
of IS6110 in fingerprinting DNA of Mycobacterium bovis. Med. Microbiol. Lett. 7:96-102.
36) Zhang, Y., G.H. Mazurek, M.D. Cave, K.D. Eisenach, Y. Pang, D.T. Murphy and R.J.
Wallace 1992. DNA polymorphisms in 5 strains of Mycobacterium tuberculosis analyzed
by Pulsed-Field gel electrophoresis: a tool for epidemiology. J. Clin. Microbiol. 30:1551-
56.
37) van Embden, J.D.A, M.D. Cave, J.T. Crawford, J.W. Dale, K.D. Eisenach, B. Gicquel, P.
Hermans, C. Martin, R. McAdam, T. M. Shinnick and P. M. Small. 1993. Strain
identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendation for
a standardized methodology. J. Clin. Microbiol. 31:406-409.
38) Plikaytis, B.B., J.T. Crawford, C.T. Woodley, W.R. Butler, K.D. Eisenach, M.D. Cave,
T.M. Shinnick 1993. Rapid amplification-based subtyping of Mycobacterium tuberculosis.
J. Gen. Microbiol 139:1537-1542.
39) Cave, M.D., K.D. Eisenach, G. Templeton, M. Salfinger, G. Mazurek, J. Bates, and J.T.
Crawford 1994. Stability of DNA fingerprint pattern produced with IS6110 strains of
Mycobacterium tuberculosis. J. Clin. Microbiol. 32:262-266.
40) Tabet, S.R., G.M. Goldbaum, T.M. Hooton, K.D. Eisenach, M.D. Cave, C.M. Nolan 1994.
Brief report: DNA fingerprinting analysis detecting a community-based tuberculosis
outbreak among HIV-infected persons. J. Infect. Dis. 169:189-192.
41) Stead, W., K. Eisenach, M.D. Cave, M. Beggs, G.L. Templeton, C.O. Thoen and J.H.
Bates 1995. When did Mycobacterium tuberculosis first occur in the New World? An
important question with public health implications. Clinical Commentary, Am. J. Resp.
Crit. Care Med. 151:1267-1268.
42) Templeton, G.L., L.A. Illing, L. Young, M.D. Cave and J.H. Bates 1995. The risk for
transmission of tuberculosis at bedside and during autopsy. Annals of Intern. Med. 12:922-
925.
43) Nolan, C.M., D. Williams, M.D. Cave, K.D. Eisenach, H. El-Hajj, T.M. Hooton, R.L.
Thompson, S.V. Goldberg 1995. Evolution of rifampin resistance in human
immunodeficiency virus-associated tuberculosis: A report of 3 cases. Am. J. Respir.. Crit.
Care Med. 152:1067-1071.
M.D. Cave, CV 3 Updated 11/17/11
44) Barnes, P., El-Hajj, H., Preston-Martin S., Cave, M.D., Jones, B.E., Otaya, M., and
Eisenach, K.D. 1996. Transmission of tuberculosis among the urban homeless. JAMA.
275: 305-307.
45) Rish, J.A., Eisenach, K.D., Cave, M.D., Reddy, M.V., Gangadharam, P.R., and Bates, J.H.
1996 Polymerase chain reaction detection of M. tuberculosis in formalin fixed tissue.
Amer. J. Respir. Crit. Care Med. 153: 1419-1423.
46) Hellyer, T.J., Fletcher, T.S., Bates, J.H., Cave, M.D., and Eisenach, K.D. 1996. Strand
displacement amplification and polymerase chain reaction for monitoring response to
treatment in patients with tuberculosis. J. Inf. Dis. 173: 934-941.
47) Chaves,F., Yang ,Z., El Hajj, H., Alonso, M., Burman, W., Eisenach, K.D. Dronda, F.,
Bates, J. H., and Cave, M. D. 1996. Usefulness of the secondary probe pTBN12 in DNA
fingerprinting of Mycobacterium tuberculosis. J. Clin Microbiol. 34: 1118-1123.
48) Beggs, M. L., Cave, M. D. and Eisenach, K. D. 1996 . Isolation of a Mycobacterium
tuberculosis sigma factor. Gene 174: 285-287.
49) Chaves, F., Dronda, F., Cave, M.D., Alonso, M., Amparo, G., Eisenach, K.D., Oretega,
M.D., Lopez Cubero, L., Fernandez, I., Catalan, S., and Bates, J.H. 1997. A longitudinal
study of transmission of tuberculosis in a large prison population. Amer. J. Respir. Crit.
Care Med. 155, 719 -725.
50) Braden, C. R., Templeton, G.L., Stead, W.W. Bates J. H., Cave, M. D., and Valway, S.
1997. Retrospective detection of laboratory cross-contamination of M. tuberculosis
cultures with use of DNA fingerprint analysis. Clinical Inf. Dis. 24, 35-40.
51) Burman W. J., Stone, B. S., Reves, R. R., Wilson, M. L., Yang, Z, El-Hajj, H., Bates, J. H.,
and Cave, M. D. 1997. The incidence of false-positive cultures for Mycobacterium
tuberculosis. Amer. J. Respir. Crit. Care Med. 155, 321-326.
52) Sreevatsan, S., Escalante, P., Pan, X., Gillies, D. A., Siddiqui, S., Khalaf, C. N., Kreiswirth,
B. N., Adams, G. L., Cave, M. D., van Embden, J. D. A., and Musser, J. M. 1996.
Identification of a polymorphic nucleotide in oxyR specific for Mycobacterium bovis. J.
Clin Microbiol. 34: 2007-2010.
53) Burman, W. J., Reves, R.R., Hawkes, A. P., Rietmeijer, C. A., Yang, Z. El-Hajj, H., Bates,
J. H. and Cave, M. D. 1997. DNA fingerprinting with two probes decreases clusters of
Mycobacterium tuberculosis. Amer. J. Respir. Crit. Care Med. 155, 1140- 1146.
54) Desjardin, L. E., Perkins, M. D., Teixeira, L., Cave, M.D. and Eisenach, K. D. 1996.
Alkaline decontamination of sputum specimens adversely effects the stability of
mycobacterial mRNA. J. Clin Microbiol. 34, 2435-2439.
55) Yang, Z. H., Chaves, F., Barnes, P. F., Burman, W. J., Koehler, J., Eisenach, K. D., Bates,
J. H., and Cave, M. D. 1996. Evaluation of a method for secondary typing of
Mycobacterium tuberculosis with pTBN12 in the epidemiologic study of tuberculosis. J.
Clin. Microbiol. 34, 3044-3048.
56) Beggs, M. L., Cave, M. D., Marlowe, C., Cloney, L., Duck, P, and Eisenach, K. D. 1996.
Characterization of a Mycobacterium tuberculosis complex direct repeat sequence for use
in cycling probe reaction. J. Clin. Microbiol. 34, 2985-2989.
57) Hellyer, T.J., DesJardin, L.E, Assaf, M.K., Bates, J.H., Cave, M.D. and Eisenach, K.D.
1996. Specificity of IS6110-based amplification assays for Mycobacterium tuberculosis
complex. J. Clin Microbiol. 34, 2843-2846.
58) Scorpio, A., Collins, D., Whipple, D., Cave, M. D., Bates J.H. and Zhang, Y. 1997. Rapid
differentiation of bovine and human tubercle bacilli based on a characteristic mutation in
the bovine pyraziminidase gene. J. Clin Microbiol. 35, 106-110.
59) Braden, C. R., Templeton, G. L., Cave, M. D., Valway, S., Onorato, I. M., Castro, K.
Moers, Yang, Z., Stead, W., and Bates, J. H. 1997. Interpretation of DNA restriction
M.D. Cave, CV 4 Updated 11/17/11
fragment polymorphism analysis of M. tuberculosis isolates from a state with a large rural
population. J. Inf. Dis. 175, 1446-1452.
60) Jones, B. E., Ryu, R., Yang, Z, Cave, M.D., Pogoda, J. M., Otaya, M. and Barnes, P. F.
1997. Chest radiographic findings in tuberculosis patients with recent or remote infection.
Amer. J. Resp. Crit. Care Med. 156, 1270-1273.
61) Barnes, P. F., Yang, Z, Preston-Martin, S., Eisenach, K. D., Jones , B. E., Otaya, M.,
Pogoda, J. M., Knowles, L., Harvey, S., and Cave, M. D. 1997. Patterns of tuberculosis
transmission in central Los Angeles. JAMA, 278, 1159-1163.
62) Yang, Z, Barnes, P. F., Chaves,F, Eisenach, K. D., Weis, S., Bates, J.H. and Cave, M. D.
1998. Diversity of DNA fingerprints of Mycobacterium tuberculosis isolates in the United
States. J. Clin. Microbiol. 36, 1003-1007.
63) Schutze, G. E., Kirby, R. S., Flick E. L., Stefanova, R., Eisenach, K. D. and Cave, M. D.
1998. The epidemiology and molecular identification of Salmonella infections in children
less than four years of age. Arch. Pediatr. Adol Med. 152, 659-654.
64) Fomukong, N., Beggs, M., El Hajj, H., Templeton, G., Eisenach, K., and Cave, M.D.
1998. Differences in the prevalence of IS6110 insertion sites in Mycobacterium
tuberculosis strains: low and high copy number of IS6110 Tubercle and Lung Disease 78,
109-116.
65) Bradford, W. Z., Koehler, J., El-Hajj, H., Hopewell P. C., Reingold, A. L., Agasino, C. B.,
Cave, M. D., Rane, S., Yang, Z, Crane, C. M. and Small, P. M. 1998 . Dissemination of
Mycobacterium tuberculosis across the San Francisco Bay area. J. Infect. Dis. 177, 1104-
1107.
66) Hellyer T. J., Desjardin, L. E., Beggs, M. L., Yang, Z., Eisenach, K. D., Cave, M. D.,
Bates, J. H., Assaf, M., and Crawford, J. T. 1998. Letter to the editor: IS6110 homologues
are present in multiple copies in Mycobacteria other than Tuberculosis-causing
mycobacteria. J. Clin. Microbiol 36, 853-854.
67) Salian, N.V., Rish, J. A., Eisenach, K. D., Cave, M. D. and Bates, J. H. 1998. Polymerase
Chain Reaction to detect Mycobacterium tuberculosis in histological specimens. American
Journal of Respiratory and Critical Care Medicine 158, 1150-1155.
68) Desjardin, L., Chen, Y., Perkins, M. D., Teixeira, L., Cave, M. D. and Eisenach, K. D.
1998. Comparison of the ABI 7700 (TaqMan) and competitive PCR for quantification of
IS6110 DNA in sputum during the treatment of tuberculosis. J. Clin. Microbiol. 36, 1964-
1968.
69) Hellyer, T.J., Desjardin, L.E., Hehman, G. L., Cave, M. D. and Eisenach, K.D. 1999.
Quantitative analysis of mRNA as a marker for viability of Mycobacterium tuberculosis. J.
Clin. Microbiol. 37, 290-295.
70) Barnes, P. F., Yang, Z., Pogoda, J. M., Preston-Martin, S., Jones, B. E., Otaya, M.,
Knowles, S., Harvey, S., Eisenach, K. D. and Cave, M. D. 1999. Foci of tuberculosis
transmission in central Los Angeles. American Journal of Respiratory and Critical Care
Medicine 159, 1081-1086.
71) Schutze, G. E., Sikes, J. D., Stefanova, R. and Cave, M. D. 1999. Home environment and
epidemiology of Salmonellosis in children. Pediatrics 103, 1-5.
72) Hellyer, T. J., Desjardin, L. E., Teixeira, L., Perkins, M. D., Cave, M. D., and Eisenach, K.
D. 1999. Detection of viable Mycobacterium tuberculosis by reverse trascriptase-strand
displacement amplification of mRNA. J. Clin. Microbiol. 37, 518-523.
73) Zhang, M., Gong, J., Yang, Z., Samten, B., Cave, M. D., and Barnes, P. F. 1999. Enhanced
capacity of a widespread strain of Mycobacterium tuberculosis to grow in macrophages. J.
Inf. Dis. 179, 1213-1217.
M.D. Cave, CV 5 Updated 11/17/11
74) Desjardin, L. E., Perkins, M. D., Wolski, K., Haun, S., Teixeira, L., Chen. Y., Johnson, J. L.,
Ellner, J. J., Dietze, R., Bates, J., Cave, M. D. and Eisenach, K. D. 1999. Measurement of
sputum Mycobacterium tuberculosis messenger RNA as a surrogate for response to
chemotherapy. Amer. J. Resp. and Crit. Care Med. 160, 203-210.
75) Wilson, R. W., Yang, Z, Kelley, M., Cave, M.D., Pogoda, J. M., Wallace, R. J., Cegielski, J.
P., Dunbar, D., Bergmire-Sweat, D. Elliot, L. B. and Barnes, P. F. 1999. Evidence for
limited spread of drug-resistant tuberculosis in Texas, based on molecular fingerprinting. J.
Clin. Microbiol. 37, 3255-3259.
77) Waecker, N.J., Stefanova, R., Cave, M.D., Davis, C.E. and Dankner, W. M. 2000.
Nosocomial transmission of Mycobacterium bovis-BCG to children receiving cancer
chemotherapy and to their health care workers. Clinical Inf. Dis. 30, 356-362.
78) Beggs, M. L., Eisenach, K. D. and Cave, M. D. 2000. Mapping of IS6110 insertion sites in
two epidemic strains of Mycobacterium tuberculosis. J. Clin Microbiol. 38, 2923-2928.
79) Yang, Z. H., Ijaz, K., Bates, JH, Eisenach, K.D, and Cave, M. D. 2000. Spoligotyping and
PGRS fingerprinting of Mycobacterium tuberculosis strains having few copies of IS6110.
J. Clin Microbiol. 38, 3572-3576.
80) Johnson, J. L., Okwera, A., Nsubuga, P., Nakibali, J. G., Whalen, C.C., Hom, D., Cave, M.
D., Yang, Z. H., Mugwera,, R. D., and Ellner, J. J. 2000. Efficacy of an unsupervised 8-
month rifampicin-containing regimen for the treatment of pulmonary tuberculosis in HIV-
infected adults. Int. J. Tuberc. Lung Dis. 41, 1032-1040.
81) Joloba ML, Whalen, CC, Cave, M. D., Eisenach KD, Johnson JL, Okwera A, Morrissey A,
Bajaksouzian S, Feagin J, Mugerwa R, Ellner J, Jacobs MR. 2000. Determination of drug
susceptibility and DNA fingerprint patterns of clinical isolates of Mycobacterium
tuberculosis from Kampala, Uganda. East Afr Med J. 77:111-115.
82) Yang, Z. H., Bates, JH, Eisenach, K.D, and Cave, M. D. 2001. Secondary typing of
Mycobacterium tuberculosis isolates with matching IS6110 fingerprints from different
geographic regions of the U.S. J. Clin. Microbiol. 39, 1691-1695.
83) Yang, Z. H., Rendon, A., Flores, A., Medina, R, Ijaz, K., Llacas, J.,, Eisenach, K.D, Bates,
J. H., Villareal, A. and Cave, M. D. 2001. A clinic- based molecular epidemiological study
of tuberculosis in Monterrey, Mexico. Int. J. Tuberc. Lung Dis. 5, 313-320.
84) Magruder, C., Woodruff, R., Minns, G. Barnett, V., Baker, P., Brady, E., Julian, T.,
Pezzino, G., Reece, M., Alejos, A., Cave, M.D., and Rothenberg, R. 2001. Cluster of
Tuberculosis cases among exotic dancers and their close contacts - Kansas, 1994-2000.
Morbidity Mortality Weekly Review 50, 291-293.
85) Braden, C. R., Morlock, G. P., Woodley, C. L., Johnson, K. M. Colombel, A. C., Cave, M.
D., Yang, Z., Valway, S. E., Onorato, I. M., and Crawford, J. T. 2001. Simultaneous
infection with multiple strains of M. tuberculosis. Clin. Infect. Dis.33, e42 - 47.
86) Breese, P. E., Burman, W. J., Hildred, M., Stone, B., Wilson, M. L., Yang, Z., and Cave,
M. D. 2001. The effect of changes in laboratory practices on the rate of false-positive
cultures for Mycobacterium tuberculosis. Arch. Path. Lab. Med. 125, 1213 - 1216.
87) McConkey, S., Williams, Michael, Weiss, D., Adams, H., Cave, M.D., Yang, Z., Lindner,
T. and Bailey, T. C. 2002. Prospective use of molecular typing of Mycobacterium
tuberculosis by use of restriction fragment - length polymorphism in a public tuberculosis
control program. Clinical Infect. Dis. 34, 612-619.
88) Dickins, A. M., Franklin, S., Stefanova, R., Schutze, G. E. Eisenach, K. D., Wesley, I., and
Cave, M.D. 2002. Diversity of Campylobacter Isolates from Retail Poultry Carcasses and
from Humans as Demonstrated by Pulsed Field Gel Electrophoresis. J. Food Protection 65,
957-962.
M.D. Cave, CV 6 Updated 11/17/11
89) Ijaz, K., Dillaha, J. A.,Yang, Z., Cave, M. D., Bates, J. H. 2002. Unrecognized tuberculosis
in a nursing home causing death with spread of tuberculosis to the community. J. Amer.
Ger. Soc. 50, 1213 - 1218.
90) Weis, S. E, D.O., Pogoda, J. E., Yang, Z, Cave, M.D., Wallace, C., Kelley, M. and Barnes,
P.F. 2002. Transmission dynamics of tuberculosis in Tarrant County, Texas. Amer. J. Resp.
and Crit. Care Med. 166, 36 - 42.
91) Li, Q., Whalen, C. C., Albert, J. M., Larkin, R., Zukowski, L., Cave, M. D. and Silver, R.
F. 2002. Differences in rate and variability of intracellular growth of a panel of clinical
isolates of Mycobacterium tuberculosis within a human monocyte model. Infection and
Immunity 70, 6489-6493.
92) Ijaz, K., Yang, Z., Matthews, H.S., Bates, J.H. and Cave, M.D. 2002. Epidemiological
evidence of transmission of M. tuberculosis among cluster members having similar DNA
fingerprinting patterns. Emerging Infectious Diseases 8, 1257 - 1259.
93) Kong, P.M., Tapy, J., Calixto, P., Burman, W.J., Reves, R.R., Yang, Z. and Cave, M.D.
2002. A tuberculin skin test screening program decreases tuberculosis transmission among
the homeless. Emerging Infectious Diseases 8, 1280 – 1284.
94) Dillaha, J. A., Yang, Z., Ijaz, K., Eisenach, K. D., Cave, M. D., Wilson, F. J., Stead, W.W.
and Bates J. H. 2002. Transmission of an endemic strain of Mycobacterium tuberculosis in
a rural community over half a century. Emerging Infectious Diseases 8, 1246 - 1248.
95) Alland, D., Whittam, T. S., Murray, M. B., Cave, M.D., Hazbon, M., Dix, K., Kokoris, M.,
Duesterhoeft, A., Eisen, J., Frazier, C., Fleischmann, R. 2003. Modeling Bacterial
Evolution with Comparative-Genome Based Marker Systems: Application to M.
tuberculosis Evolution and Pathogenesis. J. Bacteriol 185: 3392 – 3399.
96) Durmaz, R., Gunal, S., Yang, Z., Ozerol, I. H., and Cave, M. D. 2003. Molecular
epidemiology of tuberculosis in Turkey. Clin. Microbiol. Infect. 9, 873-877.
97) Theus, S.A., Cave, M. D., Eisenach, K.D. 2004. Activated THP-1 cells: an attractive model
for the assessment of intracellular growth rates of Mycobacterium tuberculosis isolates.
Infection and Immunity 72: 1169-1173.
98) Yang, Z.H., Kong, Y., Wilson, F., Foxman, B.,Fowler, A. H., Marrs, C. F., Cave, M.D.
and Bates, J.H. 2004. Identification of risk factors for extrapulmonary tuberculosis.
Clinical Infect. Dis. 38: 199-205.
99) Fennelly, K. P., Martyny, J.W. Fulton, K. E., Orme, I, Cave, M. D. and Heifets, L. 2004.
Cough-generated aerosols of Mycobacterium tuberculosis: a new method to study
infectiousness. Amer. J. Resp. and Crit. Care Med. 169, 604-609.
100) Ramaswamy, S. V., Dou, S-J, Rendon, A., Yang, Z, Cave, M.D. and Graviss, E.A. 2004.
Genotypic analysis of multiple-resistant Mycobacterium tuberculosis isolates from
Monterrey, Mexico. J. Medical Microbiol 53, 107-113.
101) Schutze, G., Flick, E., Stefanova, R., Spencer, H. J., Lensing, S. Y., Berry, D., and Cave,
M. D. 2004. Molecular epidemiologic surveillance of Salmonellosis in Arkansas. Southern
Medical Journal, 97, 583-587.
102) Ijaz, K., Yang, Z, Templeton, G, Stead, W.W., Bates, J.H. and Cave, M.D. 2004.
Persistence of a strain of Mycobacterium tuberculosis in a prison system. Int. J. Tuberc.
Lung Dis. 8, 994-1004.
103) R. M. Jasmer, L. Bozeman, K. Schwartzman, M. D. Cave, J. J. Saukkonen, B. Metchock ,
A. Khan., W. J. Burman M.D., and the Tuberculosis Trials Consortium 2004. Recurrent
Tuberculosis in the United States and Canada: Relapse or Reinfection? Amer. J. Resp. and
Clinical Care Med. 170, 1360-66.
M.D. Cave, CV 7 Updated 11/17/11
104) Theus, S.A., Cave, M. D., Eisenach, K.D. 2005. Intracellular macrophage growth rates and
cytokine profiles of M. tuberculosis strains with different transmission dynamics.
J Infect Dis. 191, 453-60.
105) M.D. Cave, Z. H. Yang, R. Stefanova, N. Fomukong, K. Ijaz, J. Bates and K.D. 2005.
Eisenach. Epidemiologic import of tuberculosis cases whose isolates have similar but not
identical IS6110 RFLP patterns. J. Clin. Microbiol 43, 1228-1233.
106) Yang, Z., Yang, D., Kong, Y., Zhang, L., Marrs, C. Foxman, B., Bates, J. Wilson, F and
Cave, M.D. 2005. Clinical Implications of Genetic Polymorphisms in the Phospholipase C
Gene (plcD) of Mycobacterium tuberculosis. Amer. J. Resp. and Clinical Care Med. 171,
1436 – 1442.
107) Hazbon, M., Bobadilla del Valle, M, Guerrero, M, León, C., Varma-Basil, M., Filliol, I.,
Cavatore,M., Colangeli, R, Billam-Jacobe,H., Fyfe, J., García-García, L., Davidow, A.,
Chaves, F., Eisenach, K., Sifuentes-Osornio, J., Ponce de León, A, Cave, M.D., and
Alland, D. 2005. Mutations at position embB306 are associated with drug resistance and
disease transmission rather than ethambutol resistance in Mycobacterium tuberculosis.
Antimicrobial Agents and Chemotherapy 49, 3794-3802.
108) Freeman R, Kato-Maeda M, Hauge KA, Horan K. L., Oren E, Narita M, Wallis CK, Cave,
M. D., Nolan C, Small PM, and Cangelosi GA. 2005. Use of rapid genomic deletion typing
to monitor a tuberculosis outbreak within an urban homeless population. J.Clin. Microbiol.
43, 5550-5554
109) S. Talarico, M. D. Cave, C. F. Marrs, B. Foxman, L. Zhang, Z. Yang. 2005. Genetic
Variation of the Mycobacterium tuberculosis PE_PGRS33 Gene among Clinical Isolates.
J. Clin. Microbiol. 43, 4954-4960.
110) Kong, Y., Cave, M.D., Yang, D, Zhang, L., Marrs C.F., Foxman, B, Bates, J.H., Wilson, F.
Mukasa, L.N., and Yang, Z.H. 2005 Distribution of insertion and deletion – associated
genetic polymorphisms among four Mycobacterium tuberculosis phospholipase C genes
and associations with extra-thoracic tuberculosis: A Population-Based Study. J. Clin.
Microbiol. 43, 6048–6053.
111) Filliol I, Motiwala AS, Cavatore M, Qi W, Hazbón M, Bobadilla del Valle M, Fyfe J,
García-García L, Rastogi N, Sola C, Brudey K, Zozio T, Guerrero MI, Leon, CI, Crabtree,
J, Angiouli, S, Eisenach KD, Durmaz R, Joloba, M, Rendon, A, Sifuentes-Osornio J, Ponce
de León A, Cave MD, Fleischmann R, Whittam TS, and Alland D. 2006. Global
Phylogeny of Mycobacterium tuberculosis based on Single Nucleotide Polymorphism
(SNP) Analysis: Insights into Tuberculosis Evolution, Phylogenetic Accuracy of other
DNA Fingerprinting Systems, and Recommendations for a Minimal Standard SNP Set. J.
Bacteriology 188, 759-722.
112) K. H. Lofy, P. D. McElroy, L. Lake, L. S. Cowan, ,L. A. Diem, S. V. Goldberg, G. A.
Cangelosi, S. P. Tribble, M. D. Cave, and M. Narita. 2006. Use of rapid genotyping
methods to guide control efforts during an outbreak of tuberculosis among a homeless
population. Int. J. Tuberc. Lung Dis. 10, 683 -689.
113) Manzour H, M. Brimacombe, M. Bobadilla del Valle, M. Cavatore, M. I. Guerrero, M.
Varma-Basil, H. Billman-Jacobe, C. Lavender, J. Fyfe, L. García-García, C. Inés León, M
Bose, F Chaves, M Murray, K D. Eisenach, J Sifuentes-Osornio, M. D. Cave, A Ponce de
León and D Alland. 2006. A population genetics study of isoniazid resistance mutations
and the evolution of multi drug-resistant tuberculosis. Antimicrobial Agents and
Chemotherapy 50, 2640 – 2649.
114) Witonski, D., R. Stefanova, A. Ranganathan, G. E. Schutze, K. D. Eisenach and M.D.
Cave. Variable number tandem repeats of Salmonella enterica subsp. enterica useful in
genotyping isolates of serovars Typhimurium and Newport . In press: J. Clin. Microbiol.
M.D. Cave, CV 8 Updated 11/17/11
115) Theus, S. A. , M. D. Cave, K. Eisenach, J. Walrath, H. Lee, W. Mackay, C. Whalen, and
R. F. Silver. Differences in the growth of paired Ugandan isolates of Mycobacterium
tuberculosis within human mononuclear phagocytes correlate with epidemiological
evidence of strain virulence. In press: Inf. and Imm.
116) Kong, Y., MD Cave, L Zhang, B Foxman, CF Marrs, JH Bates, and ZH Yang.
Association between Mycobacterium tuberculosis Beijing/W lineage Strain Infection and
Extrathoracic tuberculosis: Insight from Epidemiologic and Clinical Characterization of the
Three Principal Genetic Groups of M. tuberculosis Clinical Isolates. In press: J. Clin.
Microbiol.
117) Haddad, M.B., L. A. Diem, L. S. Cowan, M. D. Cave, J. Bettridge, L. Yun, MD, C. S.
Winkler, D. D. Ingman, T. V. Oemig, A. Lynch, J. T. Montero, S. B. McCombs, and K.
Ijaz. Tuberculosis Genotyping in Six Low-Incidence States, 2000–2003. In press: Amer. J.
Prev. Med.
Book Chapters and Review Articles:
1) Cave, M.D. 1982. Morphological manifestations of ribosomal DNA amplification during
insect oogenesis. In: Insect Ultrastructure, vol. I, (H. Akai and R. King, eds.). Plenum
Publishing Co., New York, pp. 86-117.
2) Cave, M.D. 1982. Morphological manifestations rDNA amplification during insect
oogenesis. In: Ultrastructural and Functioning of Insect Cells, (H. Akai, R. King and S.
Morohoshi, eds.). The Society for Insect Cells, Tokyo, Japan, pp. 25-28.
3) Eisenach, K.D., M.D. Cave and J.T. Crawford 1992 Polymerase chain reaction detection
of Mycobacterium tuberculosis. Diagnostic Molecular Microbiology Principles and
Applications, ASM press, Washington D.C., pp. 191-196.
4) Barnes, P. F. and Cave, M.D. 2003. Molecular Epidemiology of Tuberculosis: Relevance to
Disease Control and Pathogenesis. New England Journal of Medicine 249, 1149-1156.
5) Cave, M.D., Murray, M. and Nardell, E. 2005. Molecular epidemiology of tuberculosis. In:
Tuberculosis and the Tubercle Bacillus: (S. Cole, W. Jacobs, D. McMurray and K. Eisenach
eds.) ASM Press, Washington, D.C., pp. 33 – 46.
Books:
1) Burns, E. R. and M.D. Cave 1996. Ace the Boards series: Histology and Cell Biology,
Mosby Yearbook Publishers, St. Louis, Mo.
2) Burns, E. R. and M.D. Cave 2002. Mosby's Rapid Reviews in Histology and Cell Biology,
Mosby Yearbook Publishers, St. Louis, Mo.
Patents
(1) Crawford, J.T., K.D. Eisenach, M.D. Cave, J.H. Bates Assignee: The Board of trustees of
The University of Arkansas, Little Rock, Ark. Repetitive DNA Sequence Specific for
Mycobacterium Tuberculosis To Be Used For The Diagnosis Of Tuberculosis. Patent
numbers 5,168,039; 5,183,737; and 5,370,998.
(2) Spears, P. A., T. Hellyer, L. E. Desjardin, M. D. Cave, K. D. Eisenach Assignee: The
Board of trustees of The University of Arkansas, Little Rock, Ark., Detection of M.
tuberculosis complex via reverse transcriptase SDA. Patent number 6,156,508
Professional Society Memberships
a) Society of Sigma Xi
b) Pi Gamma Mu, National Social Science Honor Society
c) American Society for Cell Biology
M.D. Cave, CV 9 Updated 11/17/11
d) American Association of Anatomists
e) American Society for Microbiology (Chair, Mycobacteriology Division, 2003-2004)
Institutional Activities
a) Research Council of the College of Medicine, 1974-1975.
b) General Research Support Grant Committee, 1974-1975.
c) Barton Research Fund Endowment Committee, 1976.
d) Admissions Committee, Interdisciplinary Toxicology Training Program, 1976-1978.
e) Ph.D. Comprehensive Examination Committee, Interdisciplinary Toxicology Program,
1976-1979.
f) Graduate Council, University-wide, 1979-83.
h) Committee on Program Evaluation of Graduate Council, 1981-1983.
i) Graduate Committee, U.A.M.S., 1979-1983.
j) Council of Academic Affairs, College of Medicine, 1983-1985.
k) Student Affairs Subcommittee, Council of Academic Affairs, 1983-1985.
m) Director, Graduate Program in Anatomy (Neurobiology and Developmental Sciences),
1985-2005.
n) LCME Accreditation Task Force, College of Medicine, Subcommittee on Graduate
Education, Chairman, 1985.
o) College of Medicine 6-year Planning Committee, 1987.
p) UAMS Foundation Research Committee, 1990.
q) LCME Accreditation Task Force, College of Medicine, Subcommittee on Student Affairs,
1991.
r) Graduate Committee, UAMS, Chairman, 1991-1993.
s) Graduate Committee, UAMS, 1994-1995.
t) LCME Accreditation Task Force, College of Medicine, Subcommittee on basic science
departments, 1998.
u) MD/PhD Scholarship Committee 1994---2005
v) PhD Scholarship Award Committee 1993---2005.
w) Faculty Development Committee, Department of Neurobiology and Developmental
Sciences 2005
M.D. Cave, CV 10 Updated 11/17/11