CURRICULUM VITAE
Cynthia B. Peterson, Ph.D.
Department of Biochemistry and Cellular and Molecular Biology
The Center of Excellence in Structural Biology
Program in Genome Science and Technology
The University of Tennessee Telephone: (865)974-4083; FAX: (865)974-6306
M407 Walters Life Sciences Building E-mail address: cynthia_peterson@utk.edu
Knoxville, TN 37996 Web Page: http://web.bio.utk.edu/peterson
Personal Home Address: 4516 Eutaw Place
Knoxville, TN 37919
Telephone: (865)673-8203
Born: November 9, 1957
Baton Rouge, LA
Education Ph.D., Biochemistry (May, 1986)
Louisiana State University Medical Center
Shreveport, LA
M.S., Biochemistry (May, 1981)
Louisiana State University Medical Center
Shreveport, LA
B.S., Biochemistry (May, 1979)
Louisiana State University
Baton Rouge, LA
Graduated Magna Cum Laude
Research Interests
Research activities are focused on understanding the structure and function of vitronectin, an abundant protein
in the blood that regulates many physiological processes. Circulating vitronectin associates with tissue
matrices, and its presence is important in pathological situations or in cancer metastasis and tissue remodeling.
The factors that control the binding interactions and determine activities of vitronectin in the circulation as well
as in the matrix are important unsolved issues. Approaches that encompass a wide spectrum of biophysical
and cellular and molecular biological techniques are used to approach important questions regarding the
specificity of interaction of vitronectin with many of its biological targets.
Key Words: Coagulation, Fibrinolysis, Serpins, Vitronectin, Cell Adhesion, Heparin
Expertise: Hydrodynamics, Analytical Ultracentrifugation, Fluorescence Spectroscopy, Calorimetry,
Cell Culture, Expression of Recombinant Proteins, Baculovirus Technology
Teaching Emphases Protein Structure and Function
Modern Techniques in Biochemistry and Biotechnology
The Specificity and Energetics of Macromolecular Interactions
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 2
Work Experience
March, 2005 – present Associate Director
Program in Genome Science and Technology
University of Tennessee, Knoxville, TN
August, 2002 - present Professor
Department of Biochemistry and Cellular and Molecular Biology
University of Tennessee, Knoxville, TN
June, 2001 - Associate Director
December 2003 Center of Excellence in Structural Biology
University of Tennessee, Knoxville, TN
August, 1997- Associate Professor
July, 2002 Department of Biochemistry and Cellular and Molecular Biology
University of Tennessee, Knoxville, TN
January, 1992- Assistant Professor
July, 1997 Department of Biochemistry and Cellular and Molecular Biology
University of Tennessee, Knoxville, TN
1987-1991 Postdoctoral Fellow with Professor H. K. Schachman
Department of Molecular and Cell Biology and Virus Laboratory
University of California, Berkeley, CA
1986-1987 Postdoctoral Fellow with Professor Michael N. Blackburn
Department of Biochemistry and Molecular Biology
Louisiana St. Univ. Medical Center, Shreveport, LA
1980-1986 Graduate Student with Professor Michael N. Blackburn
Department of Biochemistry and Molecular Biology
Louisiana St. Univ. Medical Center, Shreveport, LA
Spring, 1979 Laboratory Instructor, Undergraduate General Chemistry Lab
Louisiana State University, Baton Rouge, LA
Honors
Phi Beta Kappa
Phi Kappa Phi
LSU Alumni Association "Top 100" Scholarship, 1975-1979
Who's Who Among American Colleges and Universities, 1979
Kontes Scholarship, W. Alton Jones Cell Science Center, 1981
First Place, 1985 Student Research Forum, LSU Medical Center
Chancellor's Award, Commencement, May, 1986
XIth International Society of Thrombosis and Haemostasis Congress Award, July, 1987,
Brussels, BELGIUM
National Research Service Award, NIH, July, 1987 - October, 1990
Travel Award, Gordon Conference on Thrombosis, March, 1994, Ventura, CA
Science Alliance Faculty Research Award, University of Tennessee Center of Excellence,
1994, 1995, 1996, 1997, 1998, 1999, 2000, 2001
Established Investigator Award, American Heart Association, July 1, 1995 to June
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 3
30, 2000
Phi Beta Kappa Certificate of Merit, Natural Sciences Division, University of
Tennessee, April, 1997
Finalist, 1998 Cardiovascular Research Prize, Council on Circulation, American
Heart Association, Lake Tahoe, CA, February 23, 1998
Finalist and Winner, 1998 YWCA Tribute to Women, Science and Technology
Category, November, 1998, Knoxville, TN
Featured Faculty by Provost Loren Crabtree, recognized on the university website for the month of
October, 2002 (http://provost.utk.edu/featured/sep02.shtml)
Featured in ITC Spotlight in recognition of use of web-interactive resources in teaching, April/May, 2003
(http://itc.utk.edu/showcase/spotlight/peterson/default.shtml)
External Support for Research (PI on all grants/support listed unless otherwise specified)
National Institutes of Health, National Heart, Lung and Blood Institute, competitive renewal of Grant No.
2R01HL50676, ―Macromolecular Interactions of Human Vitronectin,‖ July, 2003 - May, 2007;
$1, 040,000
National Institutes of Health Research Grant No. 2R01HL50676, ―Macromolecular
Interactions of Human Vitronectin,‖ December, 1998 - November, 2002; $549,769.
Grant-in-Aid, American Heart Association, Southeast Regional Affiliate, Ref. No. 0151052B, ―Use of
Analytical Chemistry and Computational Biology to Determine Structure of Vitronectin
Domains,‖ July, 2001- June, 2003, $120,000.
Established Investigator Award, American Heart Association, "The Role of Vitronectin and Its
Interactions In Hemostasis," July, 1995-June, 2000; $265,000.
National Institutes of Health FIRST Award, ―Macromolecular Interactions with Human
Vitronectin,‖ August, 1993-July, 1997; $262,750 (direct costs).
American Heart Association, Tennessee Affiliate, New Investigator Award, ―Regulation in Hemostasis
by Vitronectin,‖ July, 1993-June, 1995; $80,000. Terminated August 1, 1993 by the principal
investigator due to scientific overlap upon initiation of the NIH grant.
National Research Service Award, National Institutes of Health, ―Reversion of a pyrB
Mutant with Improper Folding, ―July, 1987-October, 1990.
American Cancer Society Postdoctoral Fellowship, July, 1987-June 1989, awarded, but
not accepted by the applicant because of overlap with the NIH award.
J. Walter Libby Postdoctoral Fellowship, American Heart Association, Louisiana, Inc.,
―Modulators of Heparin Anticoagulant Activity,‖ 1986-1987.
Student Grant-in-Aid, American Heart Association, Louisiana, Inc., ―Critical Lysines in
Antithrombin,‖ 1985-1986.
Pending Grant Applications
National Institutes of Health, NCRR Shared Instrumentation Grant Program, ―NMR Coldprobe for the
East Tennessee Area.‖ PI: Nitin Jain, Co-PI’s: Cynthia B. Peterson, Ronald Wetzel, Engin
Serpersu, David Baker, Elias Fernandez, and Tanya Kuritz; Submitted April 1, 2005; $326,500.
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 4
National Institutes of Health, R21 Exploratory/Development Grant, ―Effects of Tissue-
Type Plasminogen Activator on the Mammalian Circadian Clock.‖ PI: Rebecca A. Prosser,
Co-PI: Cynthia B. Peterson; Submitted June 1, 2005; $389,085.
National Science Foundation, Proposal No. 05443644, ―Characterizing Higher Order Complexes of
Vitronectin―, PI: Cynthia B. Peterson, Submitted July 12, 2005; $455,357.
Other External Support
Laboratory Director’s Research and Development Fund for Functional Genomics, ORNL/matching
funds from the University of Tennessee, ―Pilot Study to Develop Phenotypic Screens for Sperm
Aneuploidy and Levels of Fibrinolytic Proteins,‖ March, 1999 – February 2001; Co-Principal
Investigators: Mary Ann Handel and Cynthia B. Peterson. This pilot project was funded to
evaluate the utility and suitability of immunoassays to quantify levels of fibrinolytic proteins as a
part of a large-scale phenotypic screening effort of the Tennessee Mouse Genetics
Consortium. Dr. Peterson’s responsibility being the immunoassays for fibrinolytic proteins, and
Dr. Handel’s role involving screens for chromosome segregation. The funds have been used to
hire a technician to carry out the screens and to buy an ELISA plate reader with fluorescence
capabilities.
Howard Hughes Medical Institute, "Threshold Program in the Biological Sciences," October, 1994-
October 1998. Applicant: Frank W. Harris, Director of Biology. Co-Applicant: Neil Greenberg.
Participants: Jeff Becker, Rod Bunn, David, Fox, Jim Lawler, Beth Mullin, Bruce McKee, Denny
Mullins, Gerald Vaughan, Bruce DeLaney, John Dunlap, John Gittleman, Lou Gross, Mary Ann
Handel, Liz Howell, Ed Howley, Lee Humphreys, Faye Julian, Mike Keene, John Koontz,
Sandra Leach, Mark Littmann, Deborah McCleary, Ron McFadden, Greta McMillan, Bob
Meunchen, Mike Pelton, Cynthia Peterson, Rebecca Prosser, Susan Riechert, Gary Stacey,
and Pete Wicks. This grant was given to the institution for development of outreach programs
to stimulate and encourage interest in biological research among the undergraduate population.
The total sum of the grant over the four years was over a million dollars.
National Institutes of Health Small Equipment Grant, July 1, 1994; with matching funds from the College
of Liberal Arts and the Department of Biochemistry the award totaled $29,419; for purchase of
a MicroCal OMEGA Titration Calorimetry Accessory for the MC-2D Scanning Calorimeter
housed in the laboratory of Dr. Peterson. Applicant: Frank W. Harris, Director of Biology. Co-
Investigators: Cynthia B. Peterson, Elizabeth E. Howell, and Engin S. Serpersu.
Internal Support
Professional Development Award, University of Tennessee, ―Evaluating the Therapeutic Potential of
Vitronectin as a Drug Target.‖ November, 2004, $5000.
SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research
and the Faculty Senate Research Council, September, 2004, award to cover partial cost for
publication of an article in the Journal of Biological Chemistry, $1000.
SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research
and the Faculty Senate Research Council, July, 2004, award to cover half of the cost for
publication of an article in the Journal of Biological Chemistry, $1000.
Travel Grant, Office of Research, University of Tennessee, to attend XVIIth International Congress on
Fibrinolysis and Proteolysis in Melbourne, Australia. March 21-25, 2004. $5800.
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 5
Pilot Project Grant, Center of Excellence in Structural Biology, University of Tennessee, ―The Role of
Metals in Vitronectin Structure and Function,‖ Co-PIs: Cynthia B. Peterson and Engin
Serpersu, July, 2003-June, 2004, $10,000.
Neutron Sciences Fellowship; UT program offered through the NSF-funded International Materials
Institute the Tennessee Advanced Materials Laboratory and the Joint Institute for Neutron
Sciences; PI: Cynthia Peterson; Graduate Fellow: Cindy Brown; July, 2003-June, 2004;
$11,000.
Collaborative Research Grant, Center of Excellence in Structural Biology, University of Tennessee,
―Structural Studies on Human Vitronectin,‖ PI: Cynthia Peterson; Collaborators: Chris
Dealwis, Gary Lynn, Oakley Crawford, December, 2002-November, 2003; $40,000.
Professional Development Award, University of Tennessee, ―Microarray Analysis of Vitronectin
Knockout Mouse.‖ April, 2002, $5000.
Faculty First 2002 Award. Grant from ITC for continued development of web-based resources to
accompany BCMB 515 for Fall, 2002; December, 2001 – August, 2002; $2000.
Collaborative Research Grant, Center for Genomics and Bioinformatics, University of Tennessee,
―Molecular Characterization of Mouse Models—Links Between Obesity, Diabetes and
Cardiovascular Disease,‖ PI: Cynthia B. Peterson; Co-PI: Naima Moustaid-Moussa,
November, 2001-October, 2002, $25,000.
Matching funds for purchase of Beckman Model XL-I Analytical Ultracentrifuge received from the
Center of Excellence in Structural Biology, SARIF, the College of Arts and Sciences, the
Department of Biochemistry and Cellular and Molecular Biology, the Department of Chemistry,
the Program in Genome Science and Technology, the Materials Council at UTK, UT Medical
Center at Knoxville, and various individuals, July, 2001. Total purchase: $285,633.
Professional Development Award, University of Tennessee, ―Functional Genomics of Vitronectin
Knockout Mouse,‖ 2001- 2002, $5000.
GST Postdoctoral Fellowship, University of Tennessee and Oak Ridge National Laboratory, ―Microarray
and Proteomics Analysis of Circulating Proteins in Mouse Blood,‖ November, 2000 – October,
2002, $20,000 per year, total of $40,000 from the GST program; matching funds were obtained
from the Science Alliance at UT and the Division of Biology. Postdoctoral trainee for the
duration of the award was Christine Schar.
SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research
and the Faculty Senate Research Council, July, 2000, award to cover half of the cost for
publication of an article in the Journal of Biological Chemistry, $500.
Special Fund Allocation from the Division of Biology and the College of Arts and Sciences to sponsor
an outreach project to all first grade classrooms in Knox County. This project was implemented
in conjunction with the East Tennessee Discovery Center’s Butterfly Project, which provides
kits to all first graders containing butterfly larvae for hands-on experience in metamorphosis of
the insects. This award covered the cost of producing an educational video on butterfly
development and habitat, April, 1999, $6000.
SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research
and the Faculty Senate Research Council, February, 1999, award to cover half of the cost for
publication of an article in the Journal of Biological Chemistry, $668.
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 6
SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research
and the Faculty Senate Research Council, April, 1997, award to cover half of the
cost for publication of an article in the Journal of Biological Chemistry, $325.
SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research
and the Faculty Senate Research Council, February, 1997, award to cover half of
the cost for publication of an article in the Journal of Biological Chemistry, $673.
SARIF Exhibit, Performance, and Publication Expense Award, UTK Office of Research
and the Faculty Senate Research Council, June, 1996, award to cover half of the
cost for publication of two papers in the Journal of Biological Chemistry, $782.50.
Special Equipment Support; a one-time request for special funds for the purchase of a
control module to properly configure the Omega isothermal titration calorimeter separately from
the MicroCal MC-2D differential scanning calorimeter. Funds were obtained from a variety of
sources, including the Department of Biochemistry and Cellular and Molecular Biology, the
Division of Biology, the College of Liberal Arts, the Science Alliance, and the Office of Research
Administration. Funding of this project was coordinated by Dr. Frank Harris, with matching
funds of $3000 from Cynthia B. Peterson and Elizabeth E. Howell. Total request: $26,000.
Professional Development Award, UTK Program for Tenure-Track Faculty, 1995-96,
"Expression of a Recombinant Form of Human Plasma Vitronectin," $4300.
Faculty Research Award, University of Tennessee Professional Development Awards
Program, 1994-95, "Expression and Characterization of Recombinant Human
Vitronectin," $4200.
Biology Division, University of Tennessee, Equipment grant for the purchase of a
fluorimeter, March, 1994; $19,500. Co-Applicants: Cynthia B. Peterson
and Daniel M. Roberts.
Biology Division, University of Tennessee Science Alliance, Equipment grant for the
purchase of a stopped-flow instrument, March, 1993; $33,000. Applicant:
Elizabeth E. Howell, Co-Investigators: Cynthia B. Peterson, Engin H.
Serpersu, Jorge Churchich, Fred Hartman, and Solon Georgiou.
Ongoing Professional Collaborations
Dr. Naima Moustaid-Moussa, Associate Professor, Nutrition Department, College of Human Ecology,
University of Tennessee, Knoxville, TN. Dr. Moustaid-Moussa is working with our laboratory on the
characterization of mice as models for human disease. We are particularly interested in correlations
between cardiovascular disease and obesity, and we are using genomics and proteomics methods to
develop these relationships.
Dr. Peter Schuck, Protein Biophysics Resource, Division of Bioengineering and Physical Science, National
Institutes of Health. The laboratory at the NIH is collaborating on hydrodynamic studies using the analytical
ultracentrifuge with vitronectin. Sedimentation velocity experiments are being used to evaluate the
mechanism of assembly of higher-order PAI-1/vitronectin complexes. Dr. Schuck is working with us on
some cutting-edge analysis tools using multi-wavelength global fits to the data to evaluate stoichiometries
of the complexes.
Dr. Greg Hurst, Analytical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN. The
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 7
structure for vitronectin that has been predicted by the computational approaches is being corroborated by
work on the structure using mass spectrometry. A combination of traditional protein biochemistry using
chemical/enzymatic cleavage and HPLC is currently being employed to identify the six disulfide bonds in
vitronectin. The peptides that are disulfide cross-linked are identified by the unique mass identifier using
mass spectrometry. In a similar fashion, the three-dimensional fold of vitronectin is being approached using
chemical cross-linkers to define regions of the protein that come in close contact in the folded structure.
The peptide mapping and mass spectrometry are used in this approach to identify amino acids that are in
close proximity in the native three-dimensional structure.
Dr. Grant Blouse, Department of Biochemistry, Henry Ford Health System, Detroit, MI. The laboratory of
at the Ford Health System has provided samples of plasminogen activator inhibitor-1 for evaluation of the
energetics and specificity of vitronectin-PAI-1 interactions. Site-directed mutagenesis has been used to
introduce unique sulfhydryls into PAI-1 which can, in turn, be labeled with a variety of fluorescent probes.
The fluorophores provide a sensitive means to quantify interactions between vitronectin and PAI-1 and
evaluate structural changes, which accompany the interaction.
Professional Affiliations
American Society for Biochemists and Molecular Biologists
American Association for the Advancement of Science
The Protein Society
American Heart Association, Council on Arteriosclerosis, Thrombosis and Vascular Biology
International Society for Thrombosis and Proteolysis
Publications
Minor, K. H., Schar, C. R., Blouse, G. E., Shore, J. D., Lawrence, D. A., Schuck, P., and Peterson, C.
B. (2005) J. Biol. Chem., 280, 28711-28720. ―A Mechanism for Assembly of Complexes of Vitronectin and
Plasminogen Activator Inhibitor-1 from Sedimentation Velocity Analysis.‖
Lynn, G. W., Heller, W. T., Mayasundari, A., Minor, K. H., and Peterson, C. B. (2005) Biochemistry 44,
565-574. ―A Model for the Three-Dimensional Structure of Human Plasma Vitronectin from Small Angle
Scattering Measurements.‖
Balbo, A., Minor, K. H., Velikovsky, C. A., Mariuzza, R. A., Peterson, C. B., and Schuck, P. (2005)
Proc. Natl. Acad. Sci. USA 102, 81-86. ―Studying Multi-Protein Complexes by Multi-Signal Sedimentation
Velocity Analytical Ultracentrifugation.‖
Horn, N. A., Hurst, G. B., Mayasundari, A., Whittemore, N. A., Serpersu, E. H., and Peterson, C. B.
(2004) J. Biol. Chem. 279, 35867-35878. ―Assignment of the Four Disulfides in the N-terminal Somatomedin B
Domain of Native Vitronectin Isolated from Human Plasma.‖
Mayasundari, A., Whittemore, N. A., Serpersu. E. H. and Peterson, C. B. (2004) J. Biol. Chem. 279,
29359-29366. ―The Solution Structure of the N-terminal Domain of Human Plasma Vitronectin: Location of
Binding Sites that Regulate Fibrinolysis and Cell Migration.‖
Gupta, V., Peterson, C. B, Dice, L. T., Uchiki, T., Racca, J., Guo, J.-t, Xu, Y., Hettich, R., Zhao, X.,
Rothstein, R., and Dealwis, C. (2004) Biochemistry 43, 8568-8578. ―Sml1p is a Dimer in Solution:
Characterization of Denaturation and Renaturation of Recombinant Sml1p‖
Minor, K. H., and Peterson, C. B. (2002) J. Biol. Chem. 277,10337-10345. ―PAI-1 Promotes the Self-
Association of Vitronectin into Complexes Exhibiting Altered Incorporation into the Extracellular Matrix.‖
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 8
Podor, T. J., Campbell, S., Chindemi, P., Foulon, D. M., Farrell, D. H., Walton, P.D., Weitz, J. I., and
Peterson, C. B. (2002) J. Biol. Chem. 277, 7520-7528. "Incorporation of Vitronectin into Fibrin Clots: Evidence
for a Binding Interaction between Vitronectin and A/' Fibrinogen,"
Xu, D., Baburaj, K., Peterson, C. B., and Xu, Y. (2001) Proteins: Structure, Function and Genetics, 44,
312-320. ―A Model for the Three-Dimensional Structure of Vitronectin: Predictions for the Multi-Domain Protein
from Threading and Docking.‖
Gibson, A. D., and Peterson, C. B. (2001) Biochim. Biophys. Acta, 1545, 389-403. ―Full Length and
Truncated Forms of Vitronectin Provide Insight into Effects of Proteolytic Processing on Function.‖
Podor, T. J., Shaughnessy, S. G., Blackburn, M. N. and Peterson, C. B. (2000) J. Biol. Chem. 275,
25402-25410. ―New Insights into the Size and Stoichiometry of the Vitronectin:PAI-1 Complex.‖
Podor, T. J., Peterson, C. B., Lawrence, D. A., Stefansson, S., Stephen G. Shaughnessy, S. G.,
Foulon, D. M., Butcher, M., and Weitz, J. I. (2000) J. Biol. Chem. 275, 19788-19794. "Plasminogen Activator
Inhibitor Binds to Fibrin via Vitronectin."
Gibson, A. D., Lamerdin, J. A., Zhuang, P., Baburaj, K., Serpersu, E. H. and Peterson, C. B.(1999) J.
Biol. Chem. 274, 6432-6442. ―Orientation of Heparin-Binding Sites in Native Vitronectin: Analyses of Ligand
Binding to the Primary Glycosaminoglycan-binding Site Indicate that Putative Secondary Sites are Not
Functional."
Peterson, C. B. (1998) Trends in Cardiovascular Medicine 8, 124-131. "Binding Sites on Native and
Multimeric Vitronectin Exhibit Similar Affinity for Heparin: The Influence of Self-Association and Multivalence
on Ligand Binding." (invited review).
Stebbins, M.A., Schar, C. R., Peterson, C. B., and Sepaniak, M. J. (1998) Biotechnology Laboratory,
16, 55-57. ―Partial Digestion by Capillary Electrophoresis. A Facile Time Course Evaluation of DNA Restriction
Digests." (invited article)
Sepaniak, M., Stebbins, M., Todd, A., Gibson, T., Peterson, C., and Diack, M. (1998) Pro. of SPIE-
Soc. Opt. Eng. 3256, 162. ―Size-Selective Capillary Electrophoresis Investigations of pET3aPAI-11 DNA
Involving Restriction Digestion, Laser Induced Fluorescence Detection, and Micro-preparative Separation.‖
Zhuang, P., Chen, A. I., and Peterson, C. B. (1997) J. Biol. Chem. 272, 6858-6867. "Native and
Multimeric Vitronectin Exhibit Similar Affinity for Heparin. Differences in Heparin Binding Properties Induced
upon Denaturation are Due to Self Association into a Multimeric Form."
Gibson, A.D., Baburaj, K., Day, D. E., Verhamme, I., Shore, J. D., and Peterson, C. B. (1997) J. Biol.
Chem., 272, 5112-5121. "The Use of Fluorescent Probes to Characterize Conformational Changes in the
Interaction Between Vitronectin and Plasminogen Activator Inhibitor-1."
Stebbins, M.A., Schar, C. R., Peterson, C. B., and Sepaniak, M. J. (1997) J. Chromatography B:
(Biomedical Applications) 697, 181-188. "Temporal Analysis of DNA Restriction Digests by Capillary
Electrophoresis."
Zhuang, P., Blackburn, M. N., and Peterson, C. B. (1996) J. Biol. Chem. 271, 14323-14332.
"Characterization of the Denaturation and Renaturation of Human Plasma Vitronectin. I. Biophysical
Characterization of Protein Unfolding and Multimerization."
Zhuang, P., Li, H., Williams, J. G., Wagner, N. V., Seiffert, D., and Peterson, C. B. (1996) J. Biol.
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 9
Chem. 271, 14333-14343. "Characterization of the Denaturation and Renaturation of Human Plasma
Vitronectin. II. Investigation into the Mechanism of Formation of Multimers."
Peterson, C. B., Zhou, B.-B., Hsieh, D., Creager, A. N. H., and Schachman, H. K. (1994) Protein
Science 3, 960-966. "Association of the Catalytic Subunit of Aspartate Transcarbamoylase with a Polypeptide
Fragment Corresponding to the Zinc Domain of the Regulatory Chain Leads to Increases in Thermal Stability."
Peterson, C. B. (1993) in Biology of Vitronectins and Their Receptors (Preissner, K. T., Rosenblatt,
S., Kost, C., Wegerhoff, J., and Mosher, D. F., eds) Exerpta Medica, Vol. 1, pp. 67-74. ―Scanning
Microcalorimetry and Equilibrium Chemical Denaturation Studies of Human Plasma Vitronectin.‖
Zhuang, P., Ming, Y., Holland, J., Peterson, C. B., and Howell, E. E. (1993) J. Biol. Chem. 268, 22672-
22679. "Artificial Duplication of the R67 Dihydrofolate Reductase Gene to Create Protein Asymmetry: Effects
on Protein Activity and Folding.‖
Peterson, C. B., Burman, D. L., and Schachman, H. K. (1992) Biochemistry 31, 8508-8515. "Effects
of Replacement of Active Site Residue Gln 231 on Activity and Allosteric Properties of Aspartate
Transcarbamoylase.‖
Peterson, C. B., and Schachman, H. K. (1992) J Biol. Chem. 267, 2443-2450. "Long Range Effects of
Amino Acid Substitutions in the Catalytic Chain of Aspartate Transcarbamoylase. Localized Replacements in
the Carboxyl-terminal -Helix Cause Marked Alterations in Allosteric Properties and Intersubunit Interactions."
Peterson, C. B., and Schachman, H. K. (1991) Proc. Natl. Acad. Sci. USA 88, 458-462. "Role of a
Carboxyl-terminal Helix in the Assembly, Interchain Interactions and Stability of Aspartate Transcarbamoylase."
Horner, A. H., Kusche, M., Lindahl, U., and Peterson, C. B. (1988) Biochem. J. 251, 141-145.
"Determination of the Range in Binding Site Densities of Rat Skin Heparin Chains with High Binding Affinities
for Antithrombin."
Peterson, C. B., and Blackburn, M. N. (1988) in Proteins: Structure and Function. Proceedings for the
First Symposium of American Protein Chemists. ed., J. J. L'Italien (Plenum Press, New York), pp. 665-672.
"Localization and Interaction of Functional Sites on Antithrombin III. Use of an Anti-hapten Antibody as a
Structural Probe."
Peterson, C. B., Noyes, C. M., Pecon, J. M., Church, F. C., and Blackburn, M. N. (1987) J. Biol. Chem.
262, 8061-8065. "Identification of a Lysyl Residue in Antithrombin which is Essential for Binding of Heparin."
Peterson, C. B., Morgan, W. T., and Blackburn, M. N. (1987) J. Biol. Chem. 262, 7567-7574.
"Histidine-Rich-Glycoprotein Modulation of the Anticoagulant Activity of Heparin. Evidence for a Mechanism
Involving Competition with both Antithrombin and Thrombin for Heparin Binding."
Peterson, C. B., and Blackburn, M. N. (1987) J. Biol. Chem. 262, 7552-7558. "Antithrombin
Conformation and the Catalytic Role of Heparin. I. Does Cleavage by Thrombin Induce Structural Changes in
the Heparin-binding Region of Antithrombin?"
Peterson, C. B., and Blackburn, M. N. (1987) J. Biol. Chem. 262, 7559-7566. "Antithrombin
Conformation and the Catalytic Role of Heparin. II. Is the Heparin-induced Conformational Change in
Antithrombin Required for Rapid Inactivation of Thrombin?"
Peterson, C. B., and Blackburn, M. N. (1985) J. Biol. Chem. 260, 610-615. "Isolation and
Characterization of an Antithrombin III Variant with Reduced Carbohydrate Content and Enhanced Heparin
Binding."
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 10
Manuscripts Submitted and in Preparation
Minor, K. H., Wilkins-Port, C.E., Kuruganti, S., McKeown-Longo, P., and Peterson, C. B. Biochim.
Biophys Acta, submitted on January 14, 2005. ―Plasminogen Activator Inhibitor-1 Promotes Localization of
Vitronectin to the Extracellular Matrix in Cell Culture. "
Schar, C. R., and Peterson, C. B. (2005). ―A Deletion Mutant of Vitronectin Lacking the Somatomedin B
Domain Exhibits Residual PAI-1-binding Activity.‖
Blouse, G. E., Peterson, C. B., Minor, K. M., Perron, M. J., Saxton, A. M., Anagli, J. Y., and Shore, J.
D.. ―An Ordered Mechanism for Assembly of Complexes of Vitronectin and Plasminogen Activator Inhibitor-1:
Pre-Steady State Kinetic Analysis of Step-wise Binding and Conformational Changes that Trigger Complex
Assembly.‖
Abstracts of Recent and/or Unpublished Work
Minor, K. H., Schar, C. R., Blouse, G. E., Shore, J. D., Lawrence, D. A., Schuck, P., and Peterson, C.
th
B. (2005) Serpins 2005: The 4 International Sumposium on Serpin Structure, Function and Biology, June 5-
9,2005, Cairns, Australia. ― An Ordered Mechanism for Assembly of Complexes of Vitronectin and Plasminogen
Activator Inhibitor-1‖
Minor, K. H., Schar, C. R., Blouse, G. E., Shore, J. D., Lawrence, D. A., Schuck, P., and Peterson, C.
B. (2005) Xth International Workshop on Molecular and Cellular Biology of Plasminogen Activation, April, 2005,
Potomac, Maryland. ―An Ordered Mechanism for Assembly of Complexes of Vitronectin and Plasminogen
Activator Inhibitor-1: Sedimentation Velocity Analysis of Higher-Order Complexes in the Analytical
Ultracentrifuge.‖
Schar, C. R., Kauffman, S., Horn, N. A., Becker, J. M., and Peterson, C. B. (2004) Annual Retreat of the
Tennessee Mouse Genome Consortium, November 17-19, Fall Creek Falls, TN. “A Role for Vitronectin in
Fungal Pathogenicity.‖
Blouse, G. E., Peterson, C. B., Minor, K. H., Perron, M. J., and Anagli, J. (2004) Gordon Research
Conference on Plasminogen Activation and Extracellular Matrix Degradation. ―Plasminogen Activator
Inhibitor-1 is the Molecular Trigger Eliciting the Slow Assembly of Pro-Adhesive Vitronectin Oligomers.‖
Minor, K. H., Peterson, C. B, and Schuck, P. (2004) UK/European Analytical Ultracentrifuge
Conference, April 1, 2004, Oxford, England. “Multi-wavelength and Multi-signal Sedimentation Velocity
Analysis of Protein Interactions.‖
Lynn, B. W., Mayasundar, A., Horn, N., Heller, W., Whittemore, N., Serpersu, E., and Peterson, C. B.
(2004) XVIIth International Congress on Fibrinolysis and Proteolysis, March 21-25, 2004, Melbourne, Australia.
―A Model of the Structure of Vitronectin from Small-Angle Scattering Measurements and NMR.‖
Whittemore, N.A., Mayasundari, A., Horn, N., Serpersu, E. H. and Peterson, C. B. (2004) 227th ACS
National Meeting, Anaheim, CA, March 28-April 1, 2004, Anaheim, CA. ―Elucidation of the Structure of the
Cysteine Knot in the N-terminal Somatomedin B Domain Isolated from Native Vitronectin.‖
rd
Blouse, G. E., Minor, K. H., Peterson, C. B., Perron, M. J, and Shore, J.D. (2003) 3 General Meeting of
the International Proteolysis Society, Nagoya, Japan, November 2003. ―The Fast Two-Step Binding of
Plasminogen Activator Inhibitor-1 Triggers the Slow Assembly of Higher Order Vitronectin Complexes.‖
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 11
Minor, K. H., Blouse, G. E., and Peterson, C. B. (2003) IX International Workshop on Plasminogen
Activation, October 19-23, 2003, Capri, Italy. ―A Hydrodynamics Study to Evaluate the Mechanism of
Assembly of the PAI-1/ Vitronectin Complex.”
Mayasundari, A., Serpersu, E. S., and Peterson, C. B. (2002) Annual Meeting of American Chemical
Society, Orlando, FL. ―Structural studies on the N-terminal domain of vitronectin: A disulfide knot.‖
Horn, N. A., VerBerkmoes, N., Stephenson, J. L., Jr., Hurst, G. B. and Peterson, C. B. (2002) Gordon
Research Conference on Thrombolysis. "Identification of the Disulfides in the Somatomedin B Domain of
Vitronectin by Selective Reduction, Proteolysis and Mass Mapping."
Minor, K. H., Wilkins-Port, C., McKeon-Longo, P., and Peterson, C. B. (2002) Gordon Research
Conference on Thrombolysis. "PAI-1 and Vitronectin form Complexes that Exhibit Altered Adhesive
Properties."
Schar, C. R., Sackman, J. and Peterson, C. B. (1999) the International Congress of Thrombosis and
Haemostasis, August 14-17, 1999, Washington, D. C. ―Generation and Characterization of Endothelial
Cells Transduced with Plasminogen Activator Inhibitor-1 (PAI-1) or Vitronectin.‖
Schar, C. R., and Peterson, C. B. (1999), the Second International Symposium on Serpin Structure and
Function, June 27-July 1, 1999, Cambridge, UK. ―Efforts to increase Adhesion of Transduced Endothelial
Cells Using a Retroviral Vector Containing Plasminogen Activator Inhibitor-1 or Vitronectin.‖
Johnson, D. A., Peterson, C. B., and Stack, M. S. (1997) NATO ASI Series A: Life
Sciences vol. 298, Plenum Press, London (1998). Proceedings of a NATO Advanced Studies Institute held
June 20-30, 1997, Rhodes, Greece. "Human Mast Cell Tryptase is Pro-Angiogenic."
Peterson, C. B., Quan, J., and Schachman, H. K. (1991) FASEB Journal 5, A472. "Characterization
of Mutant Aspartate Transcarbamoylases (ATCases) with Deletions from the C-terminus of the Catalytic
Chain."
Diez-Martin, J., Sikking, R. A., Blackburn, M. N., Peterson, C. B., Fass, D. N., Bowie, E. J. W., and
Gilchrist, G. S. (1985) Meeting of the American Society of Hematology. "Acquired Inhibitor of Bovine
Thrombin.‖
Invited Lectures and Seminars
Invited Speaker, IVth International Conference on Serpin Structure, Function and Biology, Cairns, Australia,
June, 2005. ― An Ordered Mechanism for Assembly of Complexes of Vitronectin and Plasminogen
Activator Inhibitor-1‖
Invited Speaker, Xth International Workshop on Molecular and Cellular Biology of Plasminogen Activation,
Potomac, MD, April, 2005. ―An Ordered Mechanism for Assembly of Complexes of Vitronectin and
Plasminogen Activator Inhibitor-1: Sedimentation Velocity Analysis of Higher-Order Complexes in the
Analytical Ultracentrifuge.‖
Invited Speaker, XVIIth International Congress on Fibrinolysis and Proteolysis, March 21-25, 2004, Melbourne,
Australia. ―A Model of the Structure of Vitronectin from Small-Angle Scattering and NMR.‖
Pre-Game Showcase, University of Tennessee, UT vs. Kentucky, November 30, 2002. "From Research Lab to
the Hospital Room: Contributing to Better Health in Big Orange Country"
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 12
Department of Nutrition, University of Tennessee, October 25, 2002. ―Being in Two Places at the Same Time:
How the Tissue Localization of Vitronectin Influences its Role in Cancer‖
East Tennessee State University Medical Center, Department of Internal Medicine, August 27, 2002. ―Being in
Two Places at the Same Time: How the Tissue Localization of Vitronectin Influences its Role in
Cancer.‖
American Red Cross, Holland Laboratory, Bethesda, MD, November 14, 2001. "Vitronectin Binding to
Physiological Targets Alters Structural and Functional Properties."
Board of Visitors, College of Arts and Sciences, University of Tennessee, November 10, 2001. Invited by Dean
Lester to discuss proposed revision to the undergraduate biology curriculum and the HHMI application
submitted this October of 2001. "Biology as an Interdisciplinary Science—Ensuring Methodological
Training and Quantitative Competency in Life Science Undergraduates.‖
American Chemical Society, Division of Natural Science, East Tennessee Chapter, Walters State Community
College, Morristown, TN, October 23, 2001. "The Genome, the Proteome, the Physiome—What's
Next?"
Board of Trustees, University of Tennessee, October 5, 2001. Invited by Provost Crabtree to discuss proposed
revision to the undergraduate biology curriculum and the HHMI application for 10/16/01. ―Biology as an
Interdisciplinary Science—Ensuring Methodological Training and Quantitative Competency in Life
Science Undergraduates.‖
Board of Trustees, University of Tennessee, June 22, 2000. Invited by President Gilley to address what it will
take for UT to place among the top 25 public research universities. ―Biology at the University: Building
Connections.‖
American Women in Science, Knoxville/Oak Ridge Chapter, June 15, 2000, Oak Ridge, TN. ―The Mysteries of
Vitronectin: Relations to Cancer Metastasis and Tissue Remodeling.‖
Computational Biology Group, Oak Ridge National Laboratory, March 30, 2000, Oak Ridge, TN. ―Biochemical
and Computational Approaches to the Structure and Function of the Circulatory Protein, Vitronectin.‖
University of Tennessee Medical Center at Knoxville, March 28, 2000, Knoxville, TN. ―New Insights into the
Structure and Function of Vitronectin.‖
Gordon Research Conference on Thrombolysis, February, 2000, Ventura CA. ―New Insights into the Structure
and Function of Vitronectin.‖
Department of Biochemistry, University of Missouri, Kansas City, MO, November 11, 1999. ―New Insights into
the Structure and Function of Vitronectin.‖
Hamilton Civic Hospitals Research Centre, Hamilton, Ontario, May 13, 1999. ―New Insights into the Structure
of Vitronectin-PAI-1 Complexes and Influences on Cell-Binding Function.‖
Tuesday Topics seminar, College of Arts and Sciences, University of Tennessee, January 12, 1999. ―Clot
Busters--Biotechnology Solutions to Old Problems‖
1998 Cardiovascular Research Prize Finalist, Council on Circulation, American Heart Association, Scientific
Conference on Vascular and Myocardial Aspects of Ischemic Heart Disease, February 23, 1998, Lake
Tahoe, CA. ―Unexpected Properties of Vitronectin:PAI-1 Complexes and Their Role in Regulating
Plasmin Activation.‖
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 13
Gordon Research Conference on Thrombolysis, February 6, 1998, Ventura, CA. ―A Glimpse at the PAI-1-
Vitronectin Complex--Unexpected Properties and Implications for Regulating Plasmin Activation and
Receptor Interactions.‖
Department of Biochemistry and Molecular Biology, Quillen College of Medicine, East Tennessee State
University, September 18, 1997. "Evaluation of Heparin Binding to Vitronectin--Insight into the Domain
Structure of the Protein"
American Red Cross, Holland Laboratory, Bethesda, MD, June 2, 1997. "Quantitative Analysis of Heparin
Binding to Vitronectin--Insight into the Domain Structure of the Protein"
Knoxville Science Club, University of Tennessee, Knoxville, TN, January 31, 1997.
"Vitronectin: What Can We Learn From a Plasma Protein?"
Hematology Program Project Seminar Series, Vanderbilt University, Nashville, TN, November
11, 1996. "Vitronectin: An Example of Form Regulating Function."
International Symposium on the Biochemistry and Biology of Serpins, Chapel Hill, NC, April 18, 1996. "The Use
of Fluorescent Probes to Characterize Conformational Changes in the Interaction Between Vitronectin
and PAI-1." (presentation given by Angelia D. Gibson, a student working on a Ph.D. in the laboratory)
Department of Biochemistry, Louisiana State University Medical Center, Shreveport, LA, October 12, 1995.
"Vitronectin: Form, Fold and Function."
Hoechst Celanese Research Day at UTK, Knoxville, TN, February 22, 1995, platform
presentation for the Biology Division at UTK. "Vitronectin: Form and Function of a
Plasma Protein which Regulates Diverse Physiological Processes."
Department of Macromolecular Research; SmithKline and Beecham Laboratories: King of Prussia, PA,
January 6, 1995. "Vitronectin: Form, Fold and Function."
University of Tennessee Hospital, Department of Hematology, Knoxville, TN, February 22, 1994. "Vitronectin:
Form, Fold and Function."
Meeting of the ―Midwest Clotters,‖ Toledo, OH, October, 1993
Department of Macromolecular Research; Smith, Kline and Beecham Laboratories; King of
Prussia, PA, May, 1991
Center for Advanced Research in Biotechnology, Rockville, MD, May, 1991
Department of Biochemistry, University of Tennessee, Knoxville, TN, February, 1991
Department of Biochemistry and Biophysics, Iowa State University, Ames, IA, February, 1991
Department of Biochemistry, Louisiana State University Medical Center, New Orleans, LA,
January, 1991
Department of Biochemistry, West Virginia University Medical Center, Morgantown, WV,
December, 1990
Miles-Cutter Pharmaceutical Company, Berkeley, CA, October, 1988
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 14
XIth International Congress of Thrombosis and Haemostasis, Brussels, BELGIUM, July, 1987
IXth International Congress of Thrombosis and Haemostasis, San Diego, CA, July, 1985
Other Conference/Workshop Participation
Program Committee, International Society of Fibrinolysis and Proteolysis, June, 2006, San Diego, CA.
Session Chair, Plasminogen Activation Workshop, Washington, DC, April 9-13, 2005
Participant, Workshop on Analytical Ultracentrifugation, University of Connecticut, Storrs, CT, June 25-28,
2002.
Session Chair, Third International Conference on the Chemistry and Biology of Serpins, Session on Serpin-
Receptor Interactions, Chicago, IL, June, 2002.
Participant, Short Course on Gene Microarray Development and Analysis: Approaches to Heart, Lung, Blood
and Sleep Disorders, Jackson Laboratory, Bar Harbor, ME, April 24 - 28, 2002
Session Chair, Proteomics, Second Annual Retreat of the Tennessee Mouse Genome Consortium,
Montgomery Bell State Park, December 5-6, 2001.
Oral Presentation about the Tennessee Mouse Genome Consortium, ORNL Genomics Workshop, Duke
University, Durham, NC, April 30, 2001.
Oral Presentation about the Heart, Lung and Blood Application to NIH for the Tennessee Mouse Genome
Consortium (TMGC), Annual Retreat of the TMGC, Fall Creek Falls, TN, December, 2000.
Poster Presentation, International Congress of Thrombosis and Haemostasis, August 14-17, 1999,
Washington, D. C. ―Generation and Characterization of Endothelial Cells Transduced with
Plasminogen Activator Inhibitor-1 (PAI-1) or Vitronectin.‖
Poster Presentation, ACS regional meeting, October, 1999, Knoxville, TN. ―Multivalent Complexes Between
Plasminogen Activator Inhibitor-1 (PAI-1) and Vitronectin Show Enhanced Binding to Cell Surface
Receptors.‖
Organizational Committee, Biological Chemistry Section Leader, ACS regional meeting, October, 1999,
Knoxville, TN
Poster Presentation, Second International Symposium on the Biochemistry and Biology of Serpins; Cambridge,
UK; June 27-July 1, 1999. ―Effects of Binding of Plasminogen Activator Inhibitor-1 to Vitronectin:
Formation of Large Multivalent Complexes.‖
Poster Presentation, Second International Symposium on the Biochemistry and Biology of Serpins; Cambridge,
UK; June 27-July 1, 1999. ―Efforts to Increase Adhesion of Transduced Endothelial Cells Using a
Retroviral Vector Containing Plasminogen Activator Inhibitor-1 or Vitronectin.‖
Invited Participant, Research Symposium highlighting the research of fourth-year Established Investigatorship
Awardees, American Heart Association, Dallas, TX, May 1, 1999. ―Effects of Binding of Plasminogen
Activator Inhibitor-1 to Vitronectin: Formation of Large Multivalent Complexes.‖
Invited speaker, Organizational Symposium on the Tennessee Consortium for Mouse Genetics, August 24-25,
1998, Vanderbilt University, Nashville, TN. ―Potential Applications for Coagulation/Blood Proteins.‖
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 15
Invited participant on panel, NIH Workshop on Structural Biology/Functional Genomics, April 24, 1998,
Bethesda, MD. Gave a short presentation on the problems and challenges in protein expression for the
Structural Biology initiative
Poster Presentation, Partnering for Functional Genomics Research conference, ORNL/GENRAC, April 16,
1998. ―A Glimpse at the Vitronectin:PAI-1 Complex--Unexpected Properties and Their Role in
Regulating Plasmin Activation and Receptor Interactions.‖
Poster Presentation, Gordon Conference, "Thrombolysis," February 8-13, 1998, Ventura, CA. ―A Glimpse at
the Vitronectin:PAI-1 Complex--Unexpected Properties and Their Role in Regulating Plasmin Activation
and Receptor Interactions.‖
Roundtable Discussion Leader, Women in Science and Technology Conference, March 22, 1996, Oak Ridge,
TN
Poster Presentation, Gordon Conference, "Fibrinolysis," March 13-18, 1994, Ventura, CA.
Attended a workshop on the computer program, LabView, conducted by National Instruments Corporation,
February 14-18, 1994, Knoxville, TN. Served as the departmental representative to the workshop to aid
in incorporation of this software in the computer teaching lab.
Poster Presentation, First International Meeting on Vitronectins and Their Receptors, Marburg, Germany,
August, 1993.
Accepted upon application for attendance at the Gordon Conference, "Thrombosis and
Hemostasis," June, 1991, Vermont.
Ad Hoc Reviewer
Journal of Biological Chemistry Phytochemistry
Biochemistry Blood
Proteins: Structure, Function and Genetics Infection and Immunity
Archives of Biochemistry and Biophysics Journal of Proteome Research
Biochimica et Biophysica Acta Journal of Cell Science
Protein Science Journal of Clinical Investigation
Grant Reviews
Research Corporation, Tucson, AZ, January, 1992
National Institutes of Health, Shared Equipment Grants Study Section, June, 1994, Bethesda, MD
Research Corporation, Tucson, AZ, June, 1995
National Institutes of Health, Shared Equipment Grants Study Section, July, 1996, Bethesda, MD
Oak Ridge Associated Universities, Faculty Development Awards, April, 1996 (one review)
National Science Foundation, ad hoc reviewer, Molecular Biochemistry, October, 1996
Susan G. Komen Foundation and The Junior League of Knoxville, February, 1998; served on local review
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 16
panel for distribution of funds raised by the first Race for the Cure held in Knoxville, TN, in the fall of 1997.
National Science Foundation, ad hoc reviewer, Molecular Biochemistry, April, 1998
National Institutes of Health, Shared Equipment Grants Study Section, August, 1998, Bethesda, MD
Laboratory Director’s Research and Development Funds for Functional Genomics, August, 1998, Oak
Ridge National Laboratories, Oak Ridge, TN
National Institutes of Health, Biophysical Chemistry Study Section, Site Visit Review for Program Project
Grant, November 15-17, 1998
National Institutes of Health, National Heart, Lung and Blood Institute, Division of Extramural Affairs,
Special Review Committee, Program Project Grant, April 21, 1999
National Institutes of Health, National Heart, Lung and Blood Institute, Division of Extramural Affairs,
Special Review Committee, Program Project Grant, April 22, 1999
Laboratory Director’s Research and Development Funds for Functional Genomics, August, 1999, Oak
Ridge National Laboratories, Oak Ridge, TN
Laboratory Director’s Research and Development Funds for Complex Biological Systems, June-August,
2000, Oak Ridge National Laboratories, Oak Ridge, TN
Laboratory Director’s Research and Development Funds for Functional Genomics, August, 2001, Oak
Ridge National Laboratories, Oak Ridge, TN (one review)
New Initiatives Grants, Center of Excellence in Structural Biology, August, 2001, Univ. of Tennessee,
Knoxville. (chair of committee)
Panelist, Biochemistry, Biophysics, and Structural Biology Panel, Graduate Research Fellowship Program,
National Science Foundation, February 14-16, 2002, Arlington, VA.
National Institutes of Health, National Heart, Lung and Blood Institute, Division of Extramural Affairs,
Special Review Committee, Program Project Grant, May 1, 2002
National Institutes of Health, National Heart, Lung and Blood Institute, Division of Extramural Affairs,
Special Review Committee, Program Project Grant, January 10, 2003
Panelist, Biochemistry, Biophysics, and Structural Biology Panel, Graduate Research Fellowship Program,
National Science Foundation, February 12-16, 2003, Arlington, VA.
Department of Energy, EPSCoR Program, Review and Site Visit, University of Vermont, April 14-16, 2003.
National Institutes of Health, National Heart, Lung and Blood Institute, Division of Extramural Affairs,
Special Review Committee, Program Project Grant, September 17, 2003.
National Institutes of Health, Thrombosis and Hemostasis Study Section, Ad Hoc member, October 16-17,
2003.
Louisiana Board of Regents, ad hoc Review of Faculty Research Grant for EPSCoR Program, January,
2004.
National Institutes of Health, National Heart, Lung and Blood Institute, Division of Extramural Affairs,
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 17
Special Review Committee, Program Project Grant, May 4, 2004.
ORAU Powe Fellowships, ad hoc reviewer, December, 2004
Wellcome Trust, London, UK, ad hoc reviewer, January, 2005
National Science Foundation, Electrochemistry and Surface Chemistry Panel, ad hoc reviewer, March,
2005
Medical Research Council, UK, ad hoc reviewer, April, 2005.
Other Professional Service
Scientific Steering Committee, Tennessee Mouse Genome Consortium, one of two representatives
from The University of Tennessee, Knoxville, campus, August, 1998 – present
Outside Reviewer, Biochemistry Program Review, Gustavus Adolphus College, St. Peter, Minnesota,
December 2-6, 1998; interim review, November, 2000
Video Production, ―A Time for Butterflies,‖ in conjunction with the UT Center for Telecommunications
and Video, March-April, 1999. Worked with producer, Rosemary Walter, to plan and produce an
educational video on butterfly development to be distributed to all first grades in Knox County in
conjunction with the Second Annual Butterfly Project of the East Tennessee Discovery Center. This
project was sponsored by the Division of Biology and the College of Arts and Sciences.
Representative from the University of Tennessee for ―Science: Invest in the Future,‖ a signature event
of the Science Coalition, a national organization dedicated to the advancement of Science. Visited
Tennessee congressional delegation with the goal of increasing federal funding of university research,
September 21-22, 1999, Washington, D. C.
Invited to present on behalf of the Tennessee Mouse Genome Consortium to a group of scientists and
administrators from the UT Medical Center in Memphis, 7/17/2000.
Stakeholder/Advisor for the Joint Institute of Biological Sciences, Oak Ridge National Laboratory,
Summer, 2001-present
Member of the UT/ORNL Distinguished Scientist Committee, July, 2002 – December, 2004
Postdoctoral Trainees
Ping Zhuang, July 1, 1994 - April 17, 1998.
Baburaj Kunnumal, August 1, 1995 - August, 1997.
Anand Mayasundari, September 1, 1999 – present, Funded through a Postdoctoral Fellowship Award
from the American Heart Association, Southeast Regional Affiliate Ref. No. 0120344B,
―Structural and Functional Studies on the N-terminal Domain of Vitronectin,‖ from July 1, 2001 –
present; $31,500/yr.
Christine R. Schar, November 1, 2000 – present; Funded through a GST Postdoctoral Fellowship,
―Microarray and Proteomics Analysis of Circulating Proteins in Mouse Blood,‖ from November
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 18
1, 2000 – present, $40,000/yr.
Mentor for Graduate Students:
Angelia D. Gibson, Ph.D. student, Biochemistry, June 1, 1994 - May 15, 1998.
Dissertation Title: A New Approach to Vitronectin Research: Using Molecular Biology and Biophysical
Chemistry to Elucidate the Contributions of the C-terminal Domain of Vitronectin to Heparin Binding
Awards: Student Award, American Institute of Chemists Foundation, May 1998
Science Alliance Award for Outstanding Achievement by a Graduate Student, Division
of Biology, University of Tennessee, May 1998
Chancellor's Citation for Outstanding Professional Promise, University of
Tennessee, April 1998
Wright Fellowship Graduate Student Award for Research, Department of
Biochemistry and Cellular and Molecular Biology, University of Tennessee,
January 1998
Travel Award, International Symposium on the Chemistry and Biology of
SERPINS, April 1996, Chapel Hill, NC
Hilton A. Smith Graduate Fellowship, University of Tennessee, 1993-1994
Current Position: Assistant Professor, Maryville College, Maryville, TN
Christine R. Schar, Ph.D. student, Biochemistry, June 1, 1995 – March, 2000.
Dissertation Title: Expression of Vitronectin and Eukaryotic Cells: Evaluation of PAI-1 Binding and
Implications for Gene Therapy
Awards: UT Citation of Outstanding Professional Promise, April, 2000
nd
Wright Travel Award for Presentation at the 2 International Meeting on the Chemistry
and Biology of Serpins, Cambridge, UK, June, 1999
Travel Award, The Graduate School, University of Tennessee, for Presentation at the
nd
2 International Meeting on the Chemistry and Biology of Serpins, Cambridge,
UK, June, 1999
Current Position: GST Postdoctoral Fellow, University of Tennessee and Oak Ridge National
Laboratory, working on microarray and proteomics analysis of the vitronectin knockout mouse
Kenneth Minor, Ph.D. student, BCMB, June 1, 1997 – present
nd
Awards: Wright Travel Award for Presentation at the 2 International Meeting on the Chemistry
and Biology of Serpins, Cambridge, UK, June, 1999
Travel Award, The Graduate School, University of Tennessee, for Presentation at the
nd
2 International Meeting on the Chemistry and Biology of Serpins, Cambridge,
UK, June, 1999
Wright Research Fellowship for outstanding work as a BCMB graduate student,
2002-2003
iWright Travel Award for Presentation at the International Workshop on Plasminogen
Activation, Capri, Italy, October, 2003
Invited Speaker, International Analytical Ultracentrifugation Workshop, Oxford,
England, April, 2004
Dissertation title: Vitronectin and Plasminogen Activator inhibitor-1 Form higher Order Complexes that
Localize to the Extracellular Matrix and Adopt Adhesive Properties
Current Position: Postdoctoral Fellow in the laboratory of Dr. Nicolas Seeds, University of Colorado
Medical Center, Denver, CO
Secil Ozen, M.S. student, BCMB, June 1, 1999 – December, 2001
Thesis Title: Structural and Functional Analysis of the Interaction of the Thrombin-Antithrombin
Complex with Vitronectin.
Current Position: Research Associate, Zymogenetics, Seattle, WA, January, 2002 – present
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 19
Jodi Watson, M. S. student, BCMB, June 1, 2001 – November, 2003.
Thesis Title: Localizing Ligand Binding Sites Using Overlapping Recombinant Polypeptide Sequences
of Vitronectin
Current Position; Research Associate, Emory Medical School
Cindy Brown, Ph.D. student, BCMB, Jun 1, 2003 – present
Awards: CESB Fellowship, 2002-2003, 2003-2004, 2004-2005
Neutron Sciences Fellowship, 2003-2004, $11,000
Neutron Sciences Fellowship, 2004-2005, $11,000
Sumit Goswami, Ph.D. student, BCMB, June 1, 2004 - present
Undergraduate Trainees
Susan Ballinger, B. S., Biochemistry, May, 1989, University of California, Berkeley. Supervised Honors
Thesis. Thesis Title: ― Intragenic Complementation in E. coli Aspartate Transcarbamoylase.‖
Joanne Quan, B. S., Biochemistry, May, 1992, University of California, Berkeley. Supervised Honors
Thesis. Thesis Title: ―Role of the Carboxyl-terminus in the Assembly and Stability of Aspartate
Transcarbamoylase.‖
Valerie Blackmon, B.S., Biochemistry, December, 1992, supervised honors work for the
CollegeScholars Program, University of Tennessee, Knoxville.
Angelia Douglass Gibson, B.S., Cell Biology, May, 1993, University of Tennessee, Knoxville,
supervised undergraduate research for two semesters.
John Todd, B. S., Biochemistry and Math, May, 1994, University of Tennessee, Knoxville, supervised
paid employment in the summer of 1992 and then one semester of independent undergraduate
research.
Edie D. Riden, B. S., Biochemistry and Chemistry, May, 1994, University of Tennessee,
Knoxville, supervised three semesters (Summer and Fall, 1993, and Spring, 1994)
of undergraduate research, project involved using PCR to generate mutant fragment of vitronectin.
Cynthia L. Page, B. S., Biochemistry, May, 1994, University of Tennessee, Knoxville,
supervised two semesters (Fall, 1993, and Spring, 1994) of undergraduate research; project
involved cloning vitronectin into M13 phage for mutagenesis.
Dreeny Chen, Biochemistry Major, Vanderbilt University, Nashville, TN, supervised two
summers paid employment in the laboratory; summer, 1993 and summer, 1994.
Shirnil Channappa, Pre-Medicine Major, The Pennsylvania State University, University Park, PA,
supervised one summer undergraduate research; summer, 1993.
Marcus Carpenter, B. S., Biochemistry, May 1994, University of Tennessee, Knoxville,
supervised three semesters of undergraduate research (Summer and Fall, 1994, and Spring,
1995); project involved using PCR to generate mutant forms of vitronectin
Walt Chiles, B. S., Cell Biology, May, 1995, University of Tennessee; supervised two semesters of
undergraduate research in partial fulfillment of the requirements for the Whittle Scholars program;
Fall, 1994 and Spring, 1995. Thesis Title: Use of the BL21 Expression System to Optimize
Solubility Conditions of the Vitronectin Protein.
Jason Williams, B. S., Biochemistry, May, 1996, University of Tennessee; mentor for
honors thesis and undergraduate research as an Undergraduate Scholar in the Threshold Program
funded by the Howard Hughes Medical Institute; academic years 1994-95 and1995-96. Project
involved evaluating the sensitivity of vitronectin to reducing agents and the quantification of the
number of free and oxidized sulfhydryls in the protein. Thesis Title: Studies of Sulfhydryl Chemistry
in Human Vitronectin
Mike Blakeley, B. S., Biochemistry, May, 1997, University of Tennessee; supervised
undergraduate research aimed at development and pilot runs on purification of wheat germ acid
phosphatase in preparation for Biochemistry 515, the graduate student lab; summer, 1995.
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 20
Jennifer Dodd, B. S., Biology, University of Utah, May, 1993; supervised summer research prior to the
first semester of graduate school; testing fusions of thioredoxin with the C-terminal domain of
vitronectin for solubility; summer, 1995.
Colin Brinkhouse, Biochemistry Major, University of Tennessee, supervised one semester of
undergraduate research in the Fall, 1995. Colin chose to quit at that point (during his Sophomore
Year) because of lecture course commitments and time constraints
Herbert Li, B. S., Life Sciences, May, 1997, University of Tennessee; supervised in
undergraduate research an as Undergraduate Scholar in the Threshold Program funded by the
Howard Hughes Medical Institute, Fall, 1995
Janet Effler, B. S., Biochemistry and Chemistry, Spring, 1997, University of Tennessee;
supervised for independent research for the summer and fall, 1996 and spring, 1997; work focused
on the expression of recombinant fragments of vitronectin in E. coli and detection by Western
blotting, enzymatic deglycosylation of vitronectin, and measurement of interactions between
vitronectin and collagen
Doug Bradford, B. S., Biochemistry, Spring, 1997, University of Tennessee; supervised
for independent research for the summer, 1996 and spring, 1997
Cannon Turner, B.S., Biochemistry, Spring, 1998, University of Tennessee; supervised for independent
research for the spring and fall, 1997; work involved optimizing expression of recombinant fragment
of vitronectin for localization of ligand interactions
Eric Baurle, B. S., Biochemistry, Spring, 1998, University of Tennessee; supervised for
independent research for the summer, 1997; work involved developing immunochemical
techniques to monitor vitronectin interactions with collagen.
Billy Standifer, B. S., History, Emory University, B.S., BCMB, expected Spring, 1999; supervised at the
point that this student entered for a second degree; Fall, 1997; he worked on protein preparations
to gain practical experience with biochemistry
James Mosley, B. S., Life Sciences, Spring, 1999, University of Tennessee; supervised for
independent research for the Threshold Program in the Fall semester, 1997 and Spring, 1998;
worked on purifying vitronectin
Tiffany Thomas, B. S., Biochemistry, Spring, 1999, University of Tennessee; supervised for
independent research for the Threshold Program beginning summer, 1998 and working through
the1998-99 academic year on the honors thesis; project involved expressing mutant forms of
vitronectin with substitutions in the somatomedin B region using the baculovirus system. Thesis
Title: Site-Directed Mutagenesis in the PAI-1 Binding Region of Vitronectin"
Katidja Ali, B. S., Biochemistry, Summer, 1999, University of Tennessee; supervised for
independent research for the summer, 1998; worked on molecular biological aspects of expressing
vitronectin in cell culture systems
Nancy Creery, B. S., Biochemistry, Fall, 1998, University of Tennessee; supervised for independent
undergraduate research for the Fall, 1998; worked on subcloning mutant forms of vitronectin into
appropriate baculovirus expression vectors
Christal Secrest, B. S., Biochemistry, Fall, 1999; worked on characterizing a monoclonal antibody
raised against vitronectin for effects on function and localization of the recognized epitope
Melissa Alfred, B. S., Biology, Summer, 1999, B. S. Biochemistry, Spring, 2000; supervised in Fall,
1999 for independent research
Laura Terry, B.S., Biology, May, 2003 from William and Mary University; supervised in Summer, 2000
for independent research on mutagenesis and cloning of sulfhydryl mutants in the hemopexin
region of vitronectin
Hans Hartwig, B. S. Biology, Fall, 2001, University of Tennessee; supervised for two semesters in Fall,
2000 and Spring, 2001 working on expression of hemopexin-like domains in vitronectin
Jason Susong, B. S., BCMB, May, 2002, University of Tennessee; supervised for one semester of
undergraduate research in Spring, 2002, working on cloning of vitronectin into a vector for
expression in baby hamster kidney cells
John Fisher, College Scholars Program, B. S., BCMB, May, 2003, University of Tennessee; supervised
for several semesters (beginning spring 2002), working on preparing an Fab fragment of a
monoclonal antibody for vitronectin for pilot co-crystallization studies
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 21
Sheena Edwards, University Honors Student, B. S. Biomedical Engineering, 2004, University of
Tennessee, supervised for one semester on a project optimizing solid-phase integrin- binding
assays.
Ben Huff, University Honors Student, B.S., BCMB, May, 2004, University of Tennessee; supervised for
one semester on a joint project with Dr. Murray Marks in the Department of Anthropology
evaluating changes in polyamines within the first two weeks after death.
Michael Maddox, University Honors Student, B.S., BCMB, May, 2004, University of Tennessee;
supervised for one semester on a project designed to evaluate changes in gene expression in
cancer cells grown on substrata with vitronectin or vitronectin/PAI-1 complexes. This work was
pursued in collaboration with Dr. Shannon Eaker of Healthspex, Inc., Knoxville, TN.
Abdelhami Alsharif, B. S., BCMB, May, 2005, University of Tennessee. Supervised in Summer 2004,
Fall 2004 and Spring 2005 research working on binding of vitronectin to uPAR.
Ryan Buckley, B. S., BCMB, May, 2005, University of Tennessee. Supervised in Summer 2004, Fall
2004 and Spring 2005 research working on selection of clonal recombinant Chinese Hamster ovary
cell lines transfected with vitronectin.
Kevin Walters, University Honors Student, B.S. BCMB, expected in 2006, University of Tennessee.
Supervised in Spring 2005 research evaluating specific sites on vitronectin that are involved in its
self-association into an adhesion protein.
Kit Nazor, B.S. BCMB, May, 2005, University of Tennessee. Supervised in Spring 2005 research
evaluating conversion of vitronectin from a monomeric circulatory protein to a multimeric adhesive
form, testing the binding of cultured cells to the different forms associated with a commercial
extracellular matrix.
Lesley Wallace, B.S. Biology, expected May 2007 from Vanderbilt University. Supervised for Summer
2005 research on the binding and effects on function that arise from a series of monoclonal
antibodies for vitronectin.
Teaching Assignments and Professional Development
Participated as a Faculty Mentor in the GTA Mentoring Program at UTK in the 2000-2001 academic year and
again in the 2001-2002 academic year. This program is sponsored by the Graduate School and is led by Jan
Allen. Faculty mentors lead small group discussion regarding the challenges and opportunities offered by a
career in academics.
Featured faculty in ―ITC Spotlight‖ for April, 2003 for creative use of information technology in teaching. This
web site summarized new initiatives taken in teaching as a result of the 2002 ―Faculty First‖ award.
th
External Reviewer for three chapters in the 6 Edition of Biochemistry by Berg and Stryer, January, 2005
BCMB 401 ―Biochemistry‖
Spring, 2004
Fall, 2004
Spring, 2005
BCMB 420 ‖Advanced Topics in Biochemistry‖
Spring, 1992
Spring, 1993
Spring, 1998
Spring, 2005 (1 guest lecture on Angiogenesis)
BCMB 452 ―Independent Research in Biochemistry‖
Fall, 1992 (Valerie Blackmon and Angelia Douglass)
Spring, 1993 (John Todd)
Summer, 1993 (Edie Riden)
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 22
Fall, 1993 (Edie Riden and Cynthia Page)
Spring, 1994 (Edie Riden and Cynthia Page)
Summer, 1994 (Marcus Carpenter)
Fall, 1994 (Marcus Carpenter)
Spring, 1995 (Marcus Carpenter, Walt Chiles, and Jason Williams)
Summer, 1995 (Mike Blakeley)
Fall, 1995 (Jason Williams and Herbert Li)
Spring, 1996 (Jason Williams)
Summer, 1996 (Janet Effler and Doug Bradford)
Fall, 1996 (Janet Effler)
Spring, 1997 (Janet Effler and Cannon Turner)
Summer, 1997 (Eric Baurle)
Summer, 1998 (Katidja Ali)
Fall, 1998 (Tiffany Thomas and Nancy Creery)
Fall, 1999 (Melissa Alfred and Christal Secrest)
Fall, 2000 (Hans Hartwig)
Spring, 2001 (Hans Hartwig)
Spring, 2002 (Jason Susong and John Fisher)
Fall, 2002 (John Fisher and Bessie Yang)
Spring, 2003 (Bessie Yang)
Fall, 2003 (Sheena Edwards)
Spring, 2004 (Michael Maddox, Benjamin Huff)
Fall, 2004 (Abdelhamid Alsharif, Ryan Buckley)
Spring, 2005 (Abdelhamid Alsharif, Ryan Buckley, Kevin Walters, Kit Nazor)
Biochemistry 462, "Senior Seminar"
1 lecture, Spring, 1994
1 lecture, Spring, 1995
Biology 303, "Research Colloquium for the HHMI Threshold Program"
1 lecture, Spring, 1996. This presentation was intended to introduce Juniors in the Threshold Program
to the types of research that are being pursued in my laboratory.
1 lecture, Spring, 1997. This was the same sort of presentation to the new Junior class in the
Threshold Program.
Biology 395, ―Threshold Honors Laboratory Research Rotation‖
Spring, 1996
Spring, 1997
Spring, 1998
Spring, 2004
BCMB 513 ―Advanced Cell Biology‖
2 lectures, Spring, 1998
2 lectures, Spring, 1999
2 lectures, Spring, 2001
6 lectures, Spring, 2002
6 lectures, Spring, 2003; Course Coordinator
6 lectures, Spring, 2004
6 lectures, Spring, 2005
BCMB 515 ―Experimental Techniques I‖
Fall, 1993
Fall, 1994
Fall, 1995
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 23
Fall, 1996
Fall, 1997
Fall, 1998
Fall, 2000
Fall, 2001
Fall, 2002
BCMB 516 ―Experimental Techniques II‖
Spring, 1992 (Alan Smith)
Spring, 1993 (Tony Chen and Sudha Subramanian)
Spring, 1994 (Angelia D. Gibson and Toyu Huang)
Spring, 1995 (Christine Schar, Tonia Lane, and Huo Li)
Spring, 1996 (Mark Geller and Jennifer Dodd)
Spring, 1997 (Kenneth Minor)
Spring, 1998 (Vanny Narita and Shannon Eaker)
Spring, 1999 (Secil Ozen)
Spring, 2000 (Ed Wright)
Spring, 2001 (Jodi Watson and Lezlee Turner)
Spring, 2002 (Srilalitha Kuruganti, Shelley Crispin, and Shaileja Chopra
Spring, 2003 (Louisa Villeneuve, Cindy Brown, Evan Reddick)
Spring, 2004 (Sumit Goswami, Guy Wiles, Jae Hoon Bahn)
Fall, 2004 (name of student here)
LS505, GST Rotation Students
Fall, 2000 (Matt Sega)
Spring, 2001 (Christal Secrest)
Fall, 2001 (Trupti Joshi)
Fall, 2004 (Anirban Mukherjee)
BCMB 525 ―Graduate Research Participation‖
Participated continuously since Fall, 1992
BCMB 560, ―Advanced Concepts in Structural Biology/Biochemistry‖
Spring, 1999; Spring 2001: Fall 2003 (co-taught with Liz Howell)
BCMB 560/LS530, ―GST IV‖
Spring, 2003. Taught sections on spectroscopy and hydrodynamics (6 lectures).
Spring, 2004. Taught sections on spectroscopy and hydrodynamics (6 lectures).
Spring, 2005. Taught sections on spectroscopy and hydrodynamics (6 lectures).
Biochemistry 603, ―Current Topics in Biochemistry‖ seminar
Presented departmental seminar in Spring, 1993 entitled, ―Structure/Function Relationships in the
Human Plasma Glycoprotein, Vitronectin‖
BCMB 601, "Advanced Biochemistry Seminar"
Presented departmental seminar in Fall, 1995, entitled, "Vitronectin: Form and Function of a Self-
Associating Protein"
Biochemistry 621, "Advanced Topics in Protein Folding and Association"
Co-organizer of this course held in Spring, 1995, with Liz Howell. This course was a special topics
course for which leaders in the field of protein folding from all over the U.S. were invited to give a
research seminar and spend an additional class period with the students enrolled. Speakers for the
course were: Pat Jennings, University of California, San Diego; Brian Matthews, University of Oregon;
Jonathan King, M.I.T., Charles Brooks, III, Carnegie Mellon University; Janette Carey, Princeton
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 24
University; Ken Ingham, Red Cross Laboratory, Bethesda, MD; Phil Bryan, CARB; Tom Alber,
University of California, Berkeley; Carl Frieden, Washington University; Tony Gatenby, Dupont; and Jiri
Safar, NIH. Funds for the course came from the department and from the Biology Division at ORNL.
BCMB 606, Journal Club, Structural Biology, Spring, 1998
UH-348, University Honors Seminar, Spring, 2003. ―Life in the Post-Genome Era: Impacts on Modern
Science and Medicine‖
Departmental Service
Executive Committee January, 1998 – July, 2004
Chair, Search Committee,
(Junior position in Structural Biology) April, 1998-June, 1999
Undergraduate Advising, average of 12 students/year continually from 1995 to present
Graduate Student Recruiting Committee 1992-93
1993-94
1994-95
Graduate Affairs Committee, 1995-96 (Chair)
1996-97 (Chair)
1997-98 (Chair)
1998-99
1999-2000
2001-2002 (Chair)
2002-2003 (Chair)
2003-2004 (Chair)
Workload Committee 1993-94
1994-95
1995-96
1996-97
1997-98
1998-99 (Chair)
1999-2000 (Chair)
2001-2002
2002-2003
2003-2004
2004-2005 (Chair)
Wright Fellowship Committee 1997-98
2003-2004
Ad Hoc Committee to Set Up Computer Lab 1992-93
Computer Committee 1994-95
1995-96
Curriculum Committee 1994-95
2004-2005
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 25
Search Committee, Instructor for 1995-96
Biochemistry 310 and Biochemistry 419
Peer Review of Teaching
Liz Howell Fall, 1993
Sundar Venkatachalam Spring, 2005
Division of Biol. Human Subjects Committee 1996-97
Search Committee September, 2002 – December, 2003
(Two Assistant Professors in Cell Biology)
Social/Awards Committee 2003-2004
Member on Student Committees:
Janel Holland, M. S., Biochemistry, degree awarded Summer, 1993
Mathew Greenberg, M. S., Microbiology, degree awarded Fall, 1994
John Lamerdin, Ph.D., Biochemistry, degree awarded Summer, 1997
Enrico DiGiammarino, M. S., Biochemistry, Spring, 1995, degree awarded Fall, 1995; Ph.D.
Biochemistry; degree awarded Fall, 1997
Chang-Hoon Han, Ph.D., Biochemistry, degree awarded Summer, 1996
Holly Pinkart, Ph.D., Microbiology, degree awarded Fall, 1996
Yaa Difie Osei, Ph.D., Biochemistry, degree awarded Fall, 1995
Kamesh Pappu, Ph.D., Biochemistry, degree awarded Fall, 1996
HeonYong Park, Ph.D., Biochemistry, degree awarded Fall, 1996
Steve Kubala, M.S., Physics, degree awarded Spring, 1996
Stacy Gerke, M.S., Physics, degree awarded Spring, 1996
Angelia D. Gibson, Ph.D., Biochemistry, degree awarded Spring, 1998
Christine Schar, Ph.D., Biochemistry, degree awarded Fall, 1999
Jeff Wiles, M.S., Microbiology, awarded Fall, 1999
Tonia Lane, M.S., Biochemistry, degree awarded Summer, 1997
Brad Strader, M. S., Biochemistry, awarded Fall, 1997; Ph.D., BCMB, degree awarded Fall, 2002
Keith Henry, Ph.D., Cell, Molecular and Developmental Biology
Mike Stebbins, Ph.D., Chemistry, degree awarded Summer, 1997
Cynthia Brimer, M.S., Microbiology, degree awarded Summer, 1997
Fred West, M.S., Biotechnology, degree awarded Fall, 1997
Ken Price, Ph.D., Chemistry, degree awarded Summer, 1997
Jennifer Dodd, Ph.D., BCMB, awarded Spring, 2000
Michael Mohler, M.S., BCMB, degree awarded Spring, 1997
Li Weikei, M.S., BCMB, degree awarded Summer, 1997
John Wilgus, M.S., Biotechnology, degree awarded Fall, 1996
Brad Hamilton, M. S., Biotechnology, degree awarded Fall, 1997
Claire Hamilton, M. S., Biotechnology, degree awarded Summer, 1998
Kenneth W. Minor, M. S., BCMB, degree awarded Summer, 2004
Greg Delozier, M. S., Biotechnology, degree awarded Summer, 1998
Shannon Eaker, Ph.D., BCMB, degree awarded Fall, 2001
Vanny Narita, M.S., BCMB, degree awarded Spring, 2002
Ayca Akal-Strader, Ph.D., BCMB, degree awarded Summer, 2004
Paula Cameron, M. S., Engineering, degree awarded Spring, 1999
Secil Ozen, M.S., BCMB, degree awarded Fall, 2001
Drew Eckman, M.S., BCMB, degree awarded Summer, 2000
Bin Jiang, Ph.D., Chemistry, degree awarded Fall, 1999
Stephanie Hicks, Ph.D., BCMB, degree awarded Fall, 2003
Amy Inselman, Ph.D., BCMB, degree awarded Summer, 2003
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 26
Ed Wright, Ph. D., BCMB
Lori Stinnett, Ph.D., BCMB, degree awarded Spring, 2004
Jodi Watson, MS, BCMB, degree awarded Fall, 2003
Jim Shaeper, PhD, Chemistry, degree awarded Summer, 2002
Justin Holland, MS. Engineering, degree awarded Summer, 2004
Heather Connelly, Ph.D., GST Program
Qin Xu, Ph.D., BCMB
Cindy Brown, PhD, BCMB
Evan Reddick, PhD., BCMB
Demet Ataman, PhD, GST Program
Eric Vincill, PhD, BCMB
Sumit Goswami, PhD, BCMB
Member on Student Preliminary Examination Committees:
Kamesh Pappu, Fall, 1993
Heonyong Park, Fall, 1993
Mark Lubkowitz, Fall, 1994, Microbiology
JungWeon Lee, Spring, 1995
Enrico DiGiammarino, Fall, 1995; repeat exam, Spring, 1996
Keith Henry, Fall, 1996
Jennifer Dodd, Fall, 1997, Chair
Brad Strader, Fall, 1998; repeat exam, Spring, 1999
Ayca Akal-Strader, Spring, 1999; repeat exam, Fall, 1999
Vanny Narita, Fall, 1999, Chair; repeat exam, Fall, 2000
Shannon Eaker, Spring, 2000
Stephanie Hicks, Fall, 2000
Amy Inselman, Spring, 2001
Lori Stinnett, Fall, 2001
Ed Wright, Spring, 2002, Chair
Shannon Matulis, Fall, 2002
Srilalitha Kuruganti, Fall, 2003; repeat exam, Fall, 2004
Evan Reddick, Fall, 2004, Chair
Qin Xu, Fall, 2004; repeat exam, Spring, 2005
Service to the GST Program
GST Steering Committee, 1998- present
GST Recruiting Committee, Co-Chair, 1999-2001
GST Curriculum Committee, Chair, 2003 - present
GST Comprehensive Exam Committee Chair, 2003, 2004
Other Institutional Service
Departmental Representative, International Ambassadors Program, March, 1993. This program is
designed to prepare current UT international students from underrepresented countries to return to
their home countries with recruiting information about the University of Tennessee.
Departmental Representative, Meeting of Residents in Hess Hall, March, 1993. The program for this
evening, entitled "Women in the 90's," included a panel of three women who discussed family and
career issues.
Mentor, The University of Tennessee Math and Science Regional Center, Summer 1993
Mentor, NIH High School Minority Research Apprentice Program, Summer 1993
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 27
Departmental Representative, Meeting of the Naturalist Club, ―How to Choose the Right Biology Major,"
Spring, 1993; Fall, 1993
Departmental Representative, ―Biology 2000‖ committee, Fall, 1993. This committee evaluated the
current status and future needs of the Division of Biology in terms of strengthening our current
emphases and targeting new research areas.
Featured with student, Angelia D. Gibson, in a 1994 public relations brochure prepared by the Office of
Research Administration entitled, ―Teaching and Research: Partners in Learning.‖ This publication
emphasizes the positive influence that faculty research has on teaching at the undergraduate level.
Invited luncheon speaker for an event organized by female graduate students in the Biology Division
entitled, "Bring Your Daughter to Work," April 28, 1994. This program brought middle school girls
from disadvantaged backgrounds in an inner city school to U.T. to spend a day with a female
graduate student mentor.
Internal reviewer for the Academic Program review of the Department of Physics, September 26-28,
1994.
Departmental Representative, steering committee for the Threshold Program in the Biological Sciences
granted by the Howard Hughes Institute to implement the program beginning Fall, 1995.
Science Alliance Faculty Award Review Committee, Spring, 1995; Spring, 1999; Spring, 2000
Panel Member for briefing of the Advisory Board for the College of Arts and Sciences; May 5, 1994;
discussion addressed the interplay between research and teaching and emphasized the Hughes
Threshold Program
Undergraduate Advising, 1995 – present (average of 12 advisees per semester)
Speaker to NIH Summer Program for Minority High School Students, July 21, 1995; discussed research
interests with vitronectin and some personal aspects of research training and career choices
One of a panel of departmental representatives who gave short introductions of research interests to
Dr. Michael Devine, Vice-Chancellor for Research, Spring, 1996
Mentor, NIH High School Minority Research Apprentice Program, Summer 1996
Judge, Natural Sciences Category, Undergraduate Research Fair, University of Tennessee, Knoxville,
April 2, 1997
Internal reviewer for the Mid-Cycle Program review of the Department of Physics, September 22-23,
1997.
Faculty Search Committee, Department of Microbiology, work begun Fall, 1997. Position filled Spring,
1998 for AY 1998-99.
Steering Committee for the Program in Genome Science and Technology, a committee to Re-engineer
the Biomedical Graduate School at ORNL, December 1997-present
Alumni Academic Hall of Fame Board of Governors, 1998-99; 1999-2000; 2000-2001
Judge, Graduate Student Division, Poster Session, University of Tennessee Medical Center Research
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 28
Day, May 21, 1998
Faculty Development Awards Research Review Panel; University of Tennessee; Fall, 1998
Review Committee for John Muldowny, by appointment of the Chancellor's Faculty Senate Standing
Committee to Oversee Administrative Evaluation, Spring, 1999.
Chair of Internal Review Committee for the Academic Program review of the Department of
Anthropology, October, 1999. mid-cycle review September, 2003.
Panelist for the College of Arts and Sciences at the Scholars Invitational Recruiting Day on November
20, 1999. Spoke to the students and parents about the Threshold Honors Program and about the
opportunities for undergraduate research at UT.
Lecturer, Kids University, Summer 2000. Participated in a course of ―Women Role Model‖ that
th th
discussed various career options; presented to girls ages 6 through 9 grade
Faculty Mentor, GTA Mentoring Program, Academic Year 2000-2001, Academic Year 2001-2002.
Faculty Search Committee, Nutrition Department, work begun Fall, 2000. Two position filled Summer,
2001 for AY 2001-2002.
Faculty Search Committee, Head, Department of Biochemistry and Cellular and Molecular Biology,
Spring 2001, position filled same semester.
Executive Committee and Associate Director, Center of Excellence in Structural Biology, January,
2001-present
UTK Committee for University Knoxville, July, 2001 - present.
Chair, University of Tennessee Radiation Safety Committee, August, 2001 – March, 2001.
Search Committee, Radiation Safety Officer for the University of Tennessee, search commenced
August of 2001 and completed in 2002.
Featured Faculty for Classroom Visitation, Development Council for the University of Tennessee,
September 27, 2001
Search Committee, Honors Program, University of Tennessee, Knoxville, work begun March, 2002 and
completed May, 2003.
Invited Lecturer in course entitled, ―Women in Science,‖ coordinated by Dr. Charmaine Mamantov in the
Department of Chemistry. Met with the class on April 8, 2002.
Leadership Institute, University of Tennessee, Gatlinburg, TN, February 17-21, 2003.
Post-Tenure Review Committee, Review of Associate Professor Murray Marks, Department of
Anthropology, March, 2004.
Scholarship Review Committee, College of Arts and Sciences, March, 2004 – present
Reviewer, Yates Dissertation Fellowship, Graduate School, University of Tennessee, Spring, 2004.
Joint UT/ORNL Advisory Committee for construction of the JIBS facility, Spring, 2004.
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 29
Search Committee, Dean, College of Arts and Sciences, work begun June, 2004 and completed in
February of 2005.
University Honors Program Curriculum Committee, Spring, 2004 – present.
Internal Reviewer for University of Tennessee applicants for Oak Ridge Associated Universites (ORAU)
Powe grants, December, 2004.
Internal reviewer for Cunningham Teaching Award, College of Arts & Sciences, Univ. of Tennessee,
May, 2005.
Community Involvement
Junior League of Knoxville, 15 years of service as an Active Member (1984-1999) of the Junior League
in three different cities; Sustaining Member, 1999-present
Volunteer of the Month Award, March, 1990, San Francisco
Asst. Chair of Community Research and Project Development; 1995-96, Knoxville
Chair of Community Research and Project Development; 1996-97, Knoxville
Volunteer of the Month Award; April, 1996, Knoxville
Board of Directors, 1996-97, Knoxville
Knoxville Connects Advisory Board, 1996-97, Knoxville
Future Planning Committee, 1996-97, Knoxville
Outstanding Service Award, 1996-97, Knoxville
Membership Advisor, 1997-98, Knoxville
Board of Directors, 1998-99, Knoxville
Recording Secretary, 1998-99, Knoxville
Board of Directors, 1999-2000, Knoxville
Board of Directors, 2000-2001, Knoxville
Volunteer for monthly science demonstrations, Sequoyah Elementary, First Grade Classroom, 1995-96;
Second Grade Classroom, 1996-97
Board of Trustees, East Tennessee Discovery Center, November, 1995 - present
Executive Committee of the Board, February, 1997 – present
Chair, Program Committee for Smithsonian Task Force, March, 2000 - present
Board of Directors, Presbyterian Student Center, November, 1998 – October, 2001
First Presbyterian Church of Knoxville
Visitation and Evangelism Committee, 1997 - December, 1998
Christian Education Committee, May, 1998 – December, 2000
Officer Nominating Committee, Summer, 1998
Laura Pettway Lecture Series Committee, 1996-97, 2000-2003
Long-Range Plan Implementation Committee, Spring, 1999-December, 2000
Search Committee, Director of Christian Education, Summer, 1999-Spring, 2000
Board of Deacons, January, 2000-December 2002
Chair, Communications Committee, January, 2000 – December, 2001
Church School Teacher, Kindergarten, 2000 – present
Finance Committee, January, 2004 - present
Board of Directors, Region 279 of the American Youth Soccer Organization (AYSO), Child Protection
Advocate, Spring, 1999-2000 Certified Spring, 1999
CURRICULUM VITAE, Cynthia B. Peterson, Ph.D. p. 30
Nominating Committee, Fall, 1999 – 2000
Board of Directors, University Club, January 2002 - December 2004.
Board of Directors, University Club Swim Team, September, 2004 – August, 2007