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									                              Xylitol Fact Sheet
                                     CDR N. Blaine Cook
                                           January 2000
Chemical makeup: A 5-carbon sugar alcohol (other names: pentose, pentitol, polyalcohol,
polyol). It is isosweet to sucrose with about the same amount of calories.

Source: Found in nature in many fruits, berries, and vegetables, and has always been a part of
our diet. Extracted from the bark of birch trees for commercial use.

General Dental Effects: Initial investigation began in Finland in the early 1970’s. Numerous
studies over the past 25 years have suggest that a 5 - 10 gram daily consumption of xylitol in the
form of gum can result in a 30 to 85% reduction in caries.

Specific Effects:
   a. Anticariogenic effects
   b. Decreases oral levels of S. mutans.
   c. Decreases plaque formation
   d. Increases plaque pH
   e. Enhances remineralization

Mode of Action: Xylitol is not metabolized by S. mutans. Xylitol is taken into the bacterial cell
as xylitol-5-phosphate via the fructose phosphotransferase system. It accumulates intracellularly
because most cells do not have sufficient amounts of xylitol-5-phosphate dehydrogenase.
Xylitol-5-phosphate metabolites are dephosphorylated and expelled as xylitol. This energy
consuming process is termed “the futile xylitol cycle.” It is also thought that xylitol competes
with glycolysis by inhibiting glucose uptake and metabolism.

Safety: Xylitol has been extensively tested and found to be a safe and effective dietary
supplement in man. It occurs naturally in various berries, fruits, and vegetables. It is a normal
intermediate in human carbohydrate metabolism. The only observed side effect has been
gastrointestinal intolerance (laxative effect) at doses much higher than those needed to achieve
dental benefits. Generally, 50 - 70 grams/day of xylitol are well tolerated by adults. The FDA
approved xylitol in 1963 for special dietary purposes.

Effective Dose: Patients should chew two pellets or one stick of the gum for 5 minutes three to
five times per day which is equivalent to 6 to 10 grams of xylitol per day. Chewing for at least
5 minutes is recommended because that is when the concentration of xylitol in the saliva is
greatest.

Brand Name: Xylimax made by Fennobon Oy in Finland. Distributed by Bio Science, 2398
Alaska Avenue, Port Orchard, WA 98366; CLEN-DENT distributed by Advantage
International USA, Inc., 4 Side Hill Road, Westport, CT 06880

Cost: Approximately 10¢ per piece including shipping.
Xylitol                                   January 2000                          CDR N.B. Cook
Availability:
                   Sources of 100% Xylitol Sweetened Products

Xylimax Chewing gum: Flavors – Peppermint, Fruit

          Bio Science
          2398 Alaska Ave
          Port Orchard, WA 98366
          Toll Free Order Line: 800-595-1089
          FAX: 360-871-6178

          Price: $8.00 for tub of 100 chiclet pieces + shipping
          Shipping: $2.00 for a single tub order, or the actual shipping costs for orders of two or
          more tubs (save on shipping when ordering in quantity).




CLEN-DENT products: chewing gum, mints, and xylitol crystals. Products are 100% xyltiol
sweetened.

          100 Count CLEN-DENT xylitol gum (Wintermint)                           $9.95
          100 Count CLEN-DENT xylitol gum (Spearmint)                            $9.95
          100 Count CLEN-DENT xylitol gum (Fresh Fruit)                          $9.95

           180 Count CLEN-DENT xylitol mints (Wintermint)                       $19.95

           600 Count bulk bottles xylitol gum (Wintermint)                      $47.25
           600 Count bulk bottles xylitol gum (Spearmint)                       $47.25
           600 Count bulk bottles xylitol gum (Fresh Fruit)                     $47.25

           1300 Count bulk bottles xylitol gum (Wintermint)                     $94.50
           1300 Count bulk bottles xylitol gum (Spearmint)                      $94.50
           1300 Count bulk bottles xylitol gum (Fresh Fruit)                    $94.50

           2 lb. bulk bottles HEALTHY*SWEET (xylitol crystals)                  $24.95
           3.63 lb. bulk bottles HEALTHY*SWEET (xylitol crystals)               $39.95


          Advantage International USA, Inc.
          4 Side Hill Road
          Westport, CT 06880
          203-226-8442
Xylitol                                 January 2000                          CDR N.B. Cook

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3. Aminoff C, Vanninen E, and Doty TE: The occurrence, manufacture and properties of
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Xylitol                                 January 2000                          CDR N.B. Cook
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Xylitol                                 January 2000                         CDR N.B. Cook
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Xylitol                                 January 2000                         CDR N.B. Cook
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