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Animal_Physiology

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					Molecular physiology (8 ECTS):

Course status: module compulsory

The regulation of respiration, metabolisam, food intake, body temperature, extracellular
volume and composition; the integrative role of cardiovascular and nervous system
The cooperative action of systems, organs, tissues and cells within the organism. The neural,
endocrine and paracrine regulation of cardiovascular function. Cellurar basics of heart
insufficiency. Molecular mechanisams of smooth muscle cell contraction and relaxation.
Metabolic control of blood vessles diametar. Vasoactive agents of endothellial cells. Lung
ventilation, the role of surfactant. Role of hemoglobin. The role of respiratory system in
acido-base equilibrio. The chemical control of ventilation. The integrative answer to hypoxia,
hipercapnia. Neural, endocrine and paracrine control of food digestion. The role of Cl chanels.
 Secondary active transport (the role of co-transportes, symportes).Oligopeptides and amino
acid transporters. Vitamin absorption. Glomerulal filtration and kidney blood flow regulation.
The role of kidnies in blood volume control and acido-base equilibrio.H20 transport, role of
aquaporins. Transport of urea, glucose, phosphates and K, Ca and Mg ions.


1. Endocrinology: advance course with the basic of clinical endocrinology (5 ECTS)

Course status: module elective

Hormone receptors- structural and functional features. Hormones and gene expression.
Nuclear receptors. Signal transmission via G-proteins coupled receptors. cAMP signal
pathway.Posholipids and calcium signal pathway. Tirosine kinase receptors. Mitogen
activated protein kinase and growth factor mediated signal pathways. Enzyme sistems
relevant to hormone synthesis and metabolisam. Endocrine glands disfunction: primary and
secondary suficiency and deficiency. Metabolisam and food intake disorders: obesity and
anorexia nervosa.       Pancreatic hormones, diabetes melitus. Carbohydrate and lipid
metabolisam disorders.Calcitropic hormones and bone metabolisam disoreders. Endocrine
hypertension and mineralocorticoids. Renal hormones and hypertension. Sexual difrentiation
abnormalities. Reproductive endocrinology: male and female sex hormones dioorders.
Humoral manifestation of malignancies. Multiendocrine syndroms. The basic principles of
endocrinological tests and treatments.

2. Neuroendocrine physiology (5 ECTS)

Course status: module elective


The functional anatomy of hypothalamus and pituitary gland. The neuroendocrine system of
hypothalamus. Adenohypophysis and neurohypophysis. The growth hormone and growth
factors physiology in children and adults.TSH and controle of thyroid function. GnRH and
gonadotropins. The role of neurotransmitters in hypothalamic function controle. Endogenous
opioids and other neuropeptides. The effects of hormones on brain.

3. Biomedical ecophysiology – the advance course ( 5ECTS)

Course status: module elective
General abiotic and biotic factors in connection to hidrosphere, litosphere, atmosphere,
geosphere, magnosphere and cosmic space. Circadian and other time chages and their effect
on organic systems. The effects of low 02 pressure and high air pressure on aninals and
humans.The effects of different types of radiation on biological systems. The basics of
ecotoxicology. Environmental influence on aging, carcinogenesis and immune response.

4. Molecular mechanisams of pathophysiological processes ( 5 ECTS)

Course status: module elective

The molecular mechanisms of cellular responses to stress: adaptation, injury, repair and cell
death. Mitochondria and energetic homeostasis in neoplastic diseases. Mechanisms and
molecular basis of protein misfolding disease. Pathophysiology of mitochondrial diseases.
The molecular basis of obesity and metabolic syndrome. Pathopysiology of skin disease.
Proteomic and genomic approach in Pathophysiology.



5. Physiological mechanisams of stress and adaptation ( 5 ECTS)

Course status: module elective

Homeostasis. Definition of stress. The contemporary concept – specific response to differenet
stimuli. Neural and endocrine stress mediators. Stress stimulated physiological systems.
Stress inhibited physiological systems. Metabolic, cardiovascular, gastrointestinal and
reproducitive response to stress. Individual differences in stress response. Accute and chronic
stress, and recovery.

6. Oxidative stress and redox regulation ( 5 ECTS)

Course status: module elective

Oxygen toxicity and free radicals. Chemistry of oxygen radicals and other reactive species.
Reactive species of nitrogen and their role of physiology and pathophysiology. Free radicals
and toxicology. The role of reactive species in regulation of physiological processes. Redox
regulation and cell differentiation. Oxidative damage of cells. The role of oxidative stress in
aging and disease. Redox regulation and cancer.

7. Physiology of thermoregulation (5 ECTS)

Course status: module elective

Endothermic and ectothermic animals. Regional and temporal heterothermy. Homeoviscous
adaptation in ectothermic organisams. Tolerance to freezing, cryoprotectants and antifreeze
substances. Heat shock proteins. . The role of Ca-ATPase in the brain temperature rising in
some ectothermic fishes.The role of brown adipose tissue in nonshivering and diet induced
shivereing thermogenessis. Uncoupling protein, the marker of brown adipose tissue metabolic
activity. Noradrenaline, acetylcholine and bradykinin- regulation of blood vessels diametar.
Hypothalamus- endogenous thermostat. Edzogenous and endogenous pyrogens.

8. Laboratory animal science (8 ECTS)
Course status: Common elective

Introduction. The design of experiments on laboratory animals. Experimental procedure
adapted for laboratory animals welfare. The comparaive overview of legal regulations in
connection to usage of laboratory animals in scientific procedures. Laboratory animals and
their environment. Anesthesia, analgesia and euthanasia. The feeding of laboratory animals.
Ethical approach to laboratory animals usage (3Rs). The tracking of laboratory animals
behaviour. Marking and treating of animals. The analysis of scientific papers dealing with
experimental animals treatments. Aquitance with basic techiques susch as blood sampling…

				
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posted:11/16/2011
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