DBS –Parkinson patient pool by linzhengnd

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									      DBS –Parkinson patient pool
                                                   UK
Prevalence & Incidence of indication
           Geography Population1                 60,943,912
           PD prevalence rate 2                       0.24%
           Gross Gross Prevalence                    146,265
           Incidence 3 as % of prevalence                 12
           Patient Incidence                         12,189

DBS candidate pool calculation
           % refractory to medical treatment 4         40%
           N° refractory MT = Gross Prevalence       58,506
           N° pats with no health care access           2%
           Prevalence with economic exclusion         57336
           Clincal exclusion criteria 5                30%
           Prevalence after clinical exclusion        40135
           % candidates for DBS 6                      32%
Net Prevalence= Total DBS candidate pool             27,292
Net Incidence= Annual DBS candidate pool             2,729
                                                   References
Sources

                                   https://www.cia.gov/library/publications/the-world-factbook/docs/profileguide.html. The world fact book (CIA). Last update Jul 2008. Europe as
                                   Inhabitants of the following countries; Belgium, Czech Republic, Denmark, Germany, Estonia, Ireland ,Greece, Spain ,France, Italy, Cyprus ,Latvia,
Geography Population:
                                   Lithuania, Luxembourg, Netherlands, Austria, Poland, Portugal ,Finland, Sweden, United Kingdom, Iceland ,Norway, Switzerland. Source;
                                   http://epp.eurostat.ec.europa.eu/cache/ITY_PUBLIC/3-27072010-AP/EN/3-27072010-AP-EN.PDF (European Comission)

                                   EUROPE; 1,158,992* out of 483M** (0.24%) as in 2008, (calculations adapted to the targeted countries)
                                   *Source: P. Andlin-Sobocki et al, European Journal of Neurology 12 (Suppl 1) June 2005 via the EPDA.
Prevalence Rate by country
                                   http://www.parkinsonsawareness.eu.com/campaign-literature/prevalence-of-parkinsons-disease/prevalence-by-country

Incidence:                         Prevalence = Incidence x Life Span
                                   Ishihara LS, Cheesbrough A, Brayne C, et al. Estimated life expectancy of Parkinson's patients compared to the United Kingdom population Neurol
                                   Neurosurg Psychiatry 2007 Mar 30.

%refractory to medical treatment   After the first 5 years from parkinson’s Disease (pD) diagnosis, despite Best Medical treatment (BMt), 40% of the patients
moderate/advance                   experience fluctuations and dyskinesias that increase in severity and frequency over time impacting patient’s quality of life. Adler et al, Neurology.
                                   2002;58(suppl 1):s51-s56. Silberstein et al, Jounal of clinical neuroscience, 2009:
                                   Parkinsonism Relat Disord. 2007 Dec;13(8):528-31. Epub 2007 Mar 7. How many parkinsonian patients are suitable candidates for deep brain
Candidates                         stimulation of subthalamic nucleus? Results of a questionnaire.
                                   J Neurol Sci 2002 Mar 30 showed 30% of potential patients were excluded for various medical reasons. At least 30% patient refused DBS STIMULUS
Candidates                         interim report. N=2101, 32% unnapropiate to be referred

								
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