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					                    TEAM LEADER: COMPUTATIONAL
                      BIOLOGY/BIOINFORMATICS
                                                   Job Ref: R-573655
Faculty: Health and Life Sciences, Institute of Integrative Biology, Centre for Genomic Research

Salary: Depending on qualifications and experience                         Range: £36,862 - £46,696 pa

Location: University Campus (Biosciences Building)                         Hours of work: Full-Time

Tenure: 3 years initially                                                  Grade: 8

Closing Date: 9 December 2011                    Interview Date: To be confirmed
                   _____________________________________________________

       Informal enquiries to Professor Neil Hall on 0151 795 4516, email: neilhall@liv.ac.uk or
Professor Andrew Cossins on 0151 795 4510, email: cossins@liv.ac.uk or Dr Christiane Hertz-Fowler
                               on 0151 795 4417, email: chf@liv.ac.uk

 Application Procedure
 Applications should comprise:
 *A completed applicant information form
 * A copy of your full curriculum vitae
 *A statement indicating the reasons for applying for this post and how your training and experience is relevant.
 If you have any particular requirements should you be invited to interview, please make this clear in your
 application.

Submitting Applications
Applications may be submitted by e-mail to jobs@liv.ac.uk or by post or in person to: The Director of Human
Resources (Recruitment), The University of Liverpool, Hart Building, Mount Pleasant, Liverpool L3 5TQ
 ROYAL MAIL – Postal Pricing System. Please ensure that postal applications carry the correct postage according to the weight and
 measurement of the item, as items with insufficient postage will be held and delayed by the Royal Mail. Details of their pricing system are
 available online at www.royalmail.com or from a Post Office branch.


 Acknowledgement of Applications
 Please note that we are unable to acknowledge postal applications. If you would like an acknowledgement
 please enclose a stamped addressed card or envelope, and place it at the front of your application. If you e-mail
 your application you will receive an automated acknowledgement.

 Shortlisting and Interviews
 Shortlisting and interview arrangements are the responsibility of the recruiting Department. Please contact
 Lesley Parsons on 0151 795 4509, email: l.m.parsons@liv.ac.uk if you have a query after the closing date.

 Outcome of Applications
 Vacancies at the University often attract a large number of candidates and it is not always possible to respond
 individually to every application. If you have not heard from the recruiting Department by late January 2012
 please take it that your application has not been successful.

                                                                                                                         Job Ref: R-573655
                                                                                                                               Page 1 of 6
Asylum & Immigration
The University will comply with the Immigration, Asylum and Nationality Act 2006, which requires all employees
to provide documentary evidence of their legal right to work in this country prior to commencing employment.
Please be aware that you will be required to bring your passport (and visa if applicable) to interview so that it can
be copied and verified by a member of the Selection Panel. For posts requiring a recognised degree level or
equivalent qualification, and where there is no suitable UK or European Economic Area candidate, the University
will take the necessary steps to secure UK Border Agency permission for a foreign national to take up
employment.

Should a candidate require a Certificate of Sponsorship in order to take up a post they will need to meet the UK
Border Agency Tier 2 Points Based Criteria. A self assessment tool can be found on the UK Border Agency
website at: www.ukba.homeoffice.gov.uk/pointscalculator

A candidate may also be required to undertake an English Language test prior to commencing work at the
University.   Details    of      Home      Office      approved     tests    can   be     found     at:
www.ukba.homeoffice.gov.uk/sitecontent/newsarticles/pbsapprovedenglishlanguage

Further information on the eligibility criteria for Certificates of Sponsorship can be found at:
www.ukba.homeoffice.gov.uk/employers/points

Diversity and Equality
The University of Liverpool is committed to diversity and equality of opportunity. All employees and applicants
for jobs will be considered on their abilities and will not be discriminated against on the grounds of age,
caring responsibilities, colour, disability, employment status, gender, gender identity, marital status,
nationality, race or ethnic origin, religion or belief, sexual orientation, socio-economic status or any other
irrelevant distinction. Training is available to support career progression within the University.

Two Ticks Disability : Guaranteed Interview Scheme (GIS)
The University of Liverpool is committed to the employment of disabled people, and as part of our
commitment, we guarantee to interview all disabled applicants who meet the essential criteria for a post and
consider them on their abilities. If your disability prevents you completing the application form by the specified
closing date, or when the vacancy closes early, due to a high volume of applications, please call the
Recruitment Team to discuss alternative arrangements.

To apply for a post under the disability GIS, you must disclose your disability (as defined by the Disability
Discrimination Act, 2005), and mark X in the yes box on the Equal Opportunities Employment Form. This
form must be returned with your application form. Full details of the scheme are available at
www.liv.ac.uk/hr/organisational-development/Two_Ticks.htm

Accessibility

If you require copies of documentation in alternative formats, for example, large print or Braille, please
contact jobs@liv.ac.uk or telephone 0151 794 6771.

If you have any other requirements which will help you access the application or interview process or
employment opportunities at the University of Liverpool, please let us know by contacting jobs@liv.ac.uk or
telephone 0151 794 6771.

Smoking

The University has adopted a Code of Practice on Smoking, copies of which are available from the Human
Resources Department website www.liv.ac.uk/hr
GW / 11/2011

                                                                                                      Job Ref: R-573655
                                                                                                            Page 2 of 6
Centre for Genomic Research (www.liverpool.ac.uk/cgr)

The Centre for Genomic Research (CGR) is a major genomics research initiative at the University of
Liverpool. It is an expanded academic structure, which comprises the former Advanced Genomics Facility
and the Liverpool Microarray Facility, and is based in custom-designed laboratory and office accommodation
in the genomics core spaces in the Biosciences Building.

The CGR employs 18 mainly Postdoctoral members of staff. The laboratory currently runs four next
generation sequencing platforms, LifeTechnologies’ SOLiD, Illumina GAIIx, Ion Torrent as well as Roche’s
454 GS FLX and Junior platforms, supported by automated laboratory workflows and investment in high
performance computing (HPC) capability.

The CGR is involved in a diverse set of projects that range from metagenomics, de novo genome and re-
sequencing projects and expression profiling of pathogens, mammalian systems and plants to cancer
genomics, and GWAS follow-up studies. In most cases, the CGR is involved in all stages of experimental
design, sample handling and analyses. The CGR has developed a well-regarded position in the national
infrastructure for research, as evidenced by the large list of higher education institutes that take advantage of
the CGR’s capabilities, both within and outside the UK and by the contribution to and authoring of over 60
peer-reviewed scientific papers.

The Centre receives core funding from two of the main UK funding councils to provide genomics services
and bioinformatics support. The CGR has been a partner laboratory in the Natural and Environmental
Research Council’s (NERC) NERC Biomolecular Analysis Facility since 2006, with a £1.25M renewal
contract for the 2011-2014 period just having been awarded. The CGR has also secured a £2M investment
from the Medical Research Council (MRC) to become one of four hubs that will service the needs of the UK-
wide biomedical and clinical research communities.

In addition, the CGR also has a portfolio of project grants from the BBSRC and other funding agencies to
undertake specific research projects, largely centered around model organisms, infectious diseases and
plant and livestock genomics.

Led by the Centre Manager and her administration team, the CGR is implementing a plan for long-term
sustainability through recharging of services to collaborators and we foresee continuing expansion in
equipment and personnel to meet the rapidly growing demand for high-throughput sequencing. The
informatics group currently comprises a team of six informaticians and one statistician. The CGR is now
looking to recruit a principal computer biologist to not only provide oversight and leadership to the group but
to also drive the future direction of the centre. The contract for this post would initially be for 3 years, though
the Centre would expect continuance beyond this time.

Institute of Integrative Biology (www.liv.ac.uk/integrative-biology/)

The Institute comprises 65 academic staff, 120 postgraduate research students and ~100 postdoctoral
research associates. It is primarily based within the new £26M Biosciences Building, which houses 320
laboratory research places, core laboratories for cell imaging, genomics, proteomics, plant and microbial
culture, an aquarium and NMR spectroscopy. The Biosciences Building is linked to the adjacent MerseyBIO
research incubator which houses 15 business development units and is close to other major campus
buildings. Together, this provides a large-scale research environment for life and health sciences.

The University of Liverpool (www.liv.ac.uk)

The University of Liverpool is a member of the elite Russell Group of UK research universities. With 4900
staff, it currently teaches 21000 students including 2000 postgraduate students, pursuing almost 300
programmes in over 100 different subject areas. It is one of the UK's leading research institutions, with a
world-class research portfolio, and an annual turnover of £340 million, including £123 million for research.


                                                                                                    Job Ref: R-573655
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The University occupies a prime campus site, which is adjacent to the city centre and close to major
transportation hubs. The University has recently invested £200M in its campus infrastructure, and also has
developed an aggressive strategic plan for research development.


The      provision      of    sporting,     conferencing  and     exhibition   facilities is    excellent
(http://www.liv.ac.uk/about/campus-facilities.htm) and the University and city provide the full range of
academic and cultural institutions and events that one would expect in a major city region
(http://www.visitliverpool.com/site/liverpool-in-a-day).

The Post

You will provide guidance and oversight to a team of bioinformaticians within the CGR. You will primarily be
responsible for planning and carrying out next-generation sequencing analyses, making certain that the data
produced by the CGR is of high quality. You will also ensure that the CGR remains at the forefront of
development in computational biology and contribute to the future direction of the CGR.

Duties
    To plan, co-ordinate, develop and implement software and pipelines for the analysis of DNA
       sequence data generated from long- and short-read high-throughput sequencing platforms. This will
       include ensuring that code is adequately documented and adheres to best practices.

      To provide guidance and training to other member of the CGR’s informatics group as well as other
       research groups, either within the University of Liverpool or other either NERC and/or MRC-funded
       groups.

      To manage the workload of the bioinformatics group team members and to ensure that time is
       correctly allocated to different projects.

      To liaise with the CGR Directors, Centre Manager and the Sequence Production Manager to ensure
       work is planned and carried out in a timely fashion and to ensure that work is done to a high standard.

      To keep abreast of developments in genome and sequence bioinformatics and to ensure that the
       centre is at the forefront of the field.

      To oversee the maintenance and enhancement of the existing IT systems.

      To help and assist collaborators in the design of experiments and to analyse and interpret the
       resulting data.

      To establish, build and maintain collaborations within and outside the group to enhance the profile of
       the group and achieve national and international recognition.

      To assist in writing collaborative grant applications.

      To report research findings to the scientific community by writing high profile publications and
       speaking at conferences to contribute to the national and international scientific enterprise.


                                           _____________________




                                                                                                Job Ref: R-573655
                                                                                                      Page 4 of 6
Pension

     The Occupational Pension Scheme associated with this appointment is the Universities Superannuation
     Scheme (USS).

     Full particulars of the scheme can be obtained, on request, from the Director of Human Resources.

     An acceptance of this appointment will be taken as an application to join USS and have the appropriate
     contributions deducted from salary unless the Director of Human Resources is expressly notified in
     writing either before commencing employment, within three months of that date or on expiry of three
     months notice, that the appointee intends to make his or her own pension arrangements.

     Should the appointee decide to make his or her own personal pension arrangements, the University will
     not contribute to the personal arrangement. No other form of supplementation of pension benefits will be
     available from the University.

     It may be possible for a newly appointed member of staff who has not been in USS to have his or her
     accrued benefits from his or her former pension scheme transferred to the USS. In such a case, USS
     will be asked to investigate a transfer payment and will provide, on actuarial advice, a proposal for a
     number of years' credit in USS which such payment would secure. The member of staff is at liberty
     either to accept this or elect to deal with his or her accrued benefits as determined by the rules of his or
     her former scheme.




                                                                                                  Job Ref: R-573655
                                                                                                        Page 5 of 6
                                            EMPLOYEE SPECIFICATION – Shortlisting Criteria

Post Title: Team Leader                                                                 Salary: £36,862 - £46,696 pa

Faculty: Health and Life Sciences                                                       Job Ref: R-573655

        Attributes            No.                    Essential Criteria                                   Desirable Criteria
                                    (Identified from – Application form/CV/Supporting    (Identified from – Application form/CV/Supporting
                                              Statement/Interview/References)                      Statement/Interview/References)

1.    EXPERIENCE              1.1   Experience of research in an academic or commercial Experience in the use of statistical methods and/or
                                    environment                                         software packages for analysing high-throughput
                                                                                        sequencing or microarray data
                              1.2                                                       Experience in consulting with researchers on
                                                                                        experimental design and bioinformatics analysis
                              1.3                                                       Experience in providing training
                              1.4                                                       Experience in writing scientific papers


2.   EDUCATION                2.1   PhD in a biology or computer science or related
     QUALIFICATIONS                 subject
     TRAINING


3.   SKILLS, GENERAL          3.1   Good knowledge of (at least one of) Perl, Java Knowledge of SQL (or similar).
     AND SPECIAL                    Python or C++
     KNOWLEDGE                3.2   Good standard of written and spoken English      Knowledge of Web site development
                              3.3   Excellent communication and interpersonal skills Good understanding of relevant biological data


4.    PERSONAL                4.1   Ability to collaborate with bench scientists         Good presentation skills
      ATTRIBUTES AND          4.2   Highly motivated
      CIRCUMSTANCES           4.3   Highly organised



                                                                                                                                  Job Ref: R-573655
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