17- OH- Progesterone Background: 17-Hydroxyprogesterone (17-OH progesterone or 17OHP) is a C-21 steroid hormone produced during the synthesis of glucocorticoids and sex steroids. It is derived from progesterone via 17-hydroxylase, a P450c17 enzyme, or from 17-hydroxypregnenolone via 3β- hydroxysteroid dehydrogenase/∆ isomerase. 17-Hydroxyprogesterone is a natural progesterone, and in pregnancy increases in the third trimester primarily due to fetal adrenal production. This hormone is primarily produced in the adrenal glands and to some degree in the gonads, specifically the corpus luteum of the ovary. Normal levels are 3-90 ng/dl in children and in women, 15-70 ng/dl prior to ovulation, and 35-290 ng/dl during the luteal phase. 17-OHP is a precursor of cortisol and synthesized by the adrenal cortex, ovaries, testes, and placenta. It is a marker for patients with congenital adrenal hyperplasia (CAH), characterized as an autosomal recessive disorder by deficiency of cortisol due to 21 hydroxylase deficiency (90 % of the cases) which leads to ACTH induced adrenal hyperplasia. Patients present with virilization and mineralocorticoid deficiency, increased 17-ketosteroid and pregnanetriol urine values. The test is used in CAH newborn screening and diagnosis and therapy monitoring on cortisol medication. And, in the evaluation of hirsutism, infertility, hemaphroditism which may be caused by 17-hydrolase deficiency. Also, in the diagnosis of endocrine active tumors. 17-OHP is elevated to a lesser extend in 11 beta hydroxylase deficiency. To differentiate 11-deoxycortisol and desoxycorticosterone has to be determined. Reference Age/ Phase Value (ng/ml) range: Infants: Cord blood 7.4-18.7 3 days to 60 days 0.1-9.4 3 month to 11 years <0.9 12-20 years < 1.8 Adult Male: 0.4-3.3 Female: follicular 0.1-1.2 luteal 0.4-4.8 postmenopausal 0.1-0.6 Sample: 1 ml of Serum or 2 ml of whole blood in a plain tube. Duration: 2 hours after receiving the sample.
Pages to are hidden for
"Glucose Blood or urine sugar (PDF)"Please download to view full document